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Conserved domains on  [gi|51338761|sp|P16330|]
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RecName: Full=2',3'-cyclic-nucleotide 3'-phosphodiesterase; Short=CNP; Short=CNPase; Flags: Precursor

Protein Classification

NUDIX hydrolase( domain architecture ID 13597307)

NUDIX hydrolase catalyzes the hydrolysis of nucleoside diphosphates linked to other moieties (X); it requires a divalent cation, such as Mg2+ or Mn2+ for its activity; contains an AAA domain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CNPase pfam05881
2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP or CNPase); This family consists of the ...
 185-398 2.59e-147

2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP or CNPase); This family consists of the eukaryotic protein 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP). 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP) is one of the earliest myelin-related proteins expressed in differentiating oligodendrocytes and Schwann cells. CNP is abundant in the central nervous system and in oligodendrocytes. This protein is also found in mammalian photoreceptor cells, testis and lymphocytes. Although the biological function of CNP is unknown, it is thought to play a significant role in the formation of the myelin sheath, where it comprises 4% of total protein. CNP selectively cleaves 2',3'-cyclic nucleotides to produce 2'-nucleotides in vitro. Although physiologically relevant substrates with 2',3'-cyclic termini are still unknown, numerous cyclic phosphate containing RNAs occur transiently within eukaryotic cells. Other known protein families capable of hydrolysing 2',3'-cyclic nucleotides include tRNA ligases and plant cyclic phosphodiesterases. The catalytic domains from all these proteins contain two tetra-peptide motifs H-X-T/S-X, where X is usually a hydrophobic residue. Mutation of either histidine in CNP abolishes enzymatic activity. CNPases belong to the 2H phosphoesterase superfamily. They share a common active site, characterized by two conserved histidines, with the bacterial tRNA-ligating enzyme LigT, vertebrate myelin-associated 2',3' phosphodiesterases, plant Arabidopsis thaliana CPDases and several several bacteria and virus proteins.


:

Pssm-ID: 461769  Cd Length: 214  Bit Score: 416.93  E-value: 2.59e-147
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51338761   185 LPLYFGWFLTKKSSETLRKAGQVFLEELGNHKAFKKELRHFISGDEPKEKLELVSYFGKRPPGVLHCTTKFCDYGKAAGA 264
Cdd:pfam05881   1 LPLYFGWFLTKKSSEALRKTGQVFLEELGNHKAFKKELRHFQSGDEPKEKIDLTSYFGKRPPGVLHCTTKFCDYGKAPGA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51338761   265 EEYAQQEVVKRSYGKAFKLSISALFVTPKTAGAQVVLTDQELQLWPSDLDKPSASEGLPPGSRAHVTLGCAADVQPVQTG 344
Cdd:pfam05881  81 EEYAQQDVVKKSYGKAFTLSISALFVTPKTVGARVELNEQQLALWPADVDKLSPSDSLPKGSRAHVTLGCASDVEAVQTG 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 51338761   345 LDLLDILQQVKGGSQGEAVGELPRGKLYSLGKGRWMLSLTKKMEVKAIFTGYYG 398
Cdd:pfam05881 161 LDLLEIVKLEKGGSQGEEVGELGRGKLQSLGNGRWMLSLAKKIEVRAIFSGYYG 214
COG4639 super family cl44097
Predicted kinase [General function prediction only];
50-147 2.56e-13

Predicted kinase [General function prediction only];


The actual alignment was detected with superfamily member COG4639:

Pssm-ID: 443677 [Multi-domain]  Cd Length: 145  Bit Score: 66.78  E-value: 2.56e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51338761  50 KTLFILRGLPGSGKSTLARlileKYHDGTKMVSADAY----KIIPGSRADFSEAYKRLDEDLAGYCRRDiRVLVLDDTNH 125
Cdd:COG4639   2 LSLVVLIGLPGSGKSTFAR----RLFAPTEVVSSDDIrallGGDENDQSAWGDVFQLAHEIARARLRAG-RLTVVDATNL 76

                        90       100
                ....*....|....*....|..
gi 51338761 126 ERERLDQLFEMADQYQYQVVLV 147
Cdd:COG4639  77 QREARRRLLALARAYGALVVAV 98
 
Name Accession Description Interval E-value
CNPase pfam05881
2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP or CNPase); This family consists of the ...
 185-398 2.59e-147

2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP or CNPase); This family consists of the eukaryotic protein 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP). 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP) is one of the earliest myelin-related proteins expressed in differentiating oligodendrocytes and Schwann cells. CNP is abundant in the central nervous system and in oligodendrocytes. This protein is also found in mammalian photoreceptor cells, testis and lymphocytes. Although the biological function of CNP is unknown, it is thought to play a significant role in the formation of the myelin sheath, where it comprises 4% of total protein. CNP selectively cleaves 2',3'-cyclic nucleotides to produce 2'-nucleotides in vitro. Although physiologically relevant substrates with 2',3'-cyclic termini are still unknown, numerous cyclic phosphate containing RNAs occur transiently within eukaryotic cells. Other known protein families capable of hydrolysing 2',3'-cyclic nucleotides include tRNA ligases and plant cyclic phosphodiesterases. The catalytic domains from all these proteins contain two tetra-peptide motifs H-X-T/S-X, where X is usually a hydrophobic residue. Mutation of either histidine in CNP abolishes enzymatic activity. CNPases belong to the 2H phosphoesterase superfamily. They share a common active site, characterized by two conserved histidines, with the bacterial tRNA-ligating enzyme LigT, vertebrate myelin-associated 2',3' phosphodiesterases, plant Arabidopsis thaliana CPDases and several several bacteria and virus proteins.


Pssm-ID: 461769  Cd Length: 214  Bit Score: 416.93  E-value: 2.59e-147
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51338761   185 LPLYFGWFLTKKSSETLRKAGQVFLEELGNHKAFKKELRHFISGDEPKEKLELVSYFGKRPPGVLHCTTKFCDYGKAAGA 264
Cdd:pfam05881   1 LPLYFGWFLTKKSSEALRKTGQVFLEELGNHKAFKKELRHFQSGDEPKEKIDLTSYFGKRPPGVLHCTTKFCDYGKAPGA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51338761   265 EEYAQQEVVKRSYGKAFKLSISALFVTPKTAGAQVVLTDQELQLWPSDLDKPSASEGLPPGSRAHVTLGCAADVQPVQTG 344
Cdd:pfam05881  81 EEYAQQDVVKKSYGKAFTLSISALFVTPKTVGARVELNEQQLALWPADVDKLSPSDSLPKGSRAHVTLGCASDVEAVQTG 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 51338761   345 LDLLDILQQVKGGSQGEAVGELPRGKLYSLGKGRWMLSLTKKMEVKAIFTGYYG 398
Cdd:pfam05881 161 LDLLEIVKLEKGGSQGEEVGELGRGKLQSLGNGRWMLSLAKKIEVRAIFSGYYG 214
COG4639 COG4639
Predicted kinase [General function prediction only];
50-147 2.56e-13

Predicted kinase [General function prediction only];


Pssm-ID: 443677 [Multi-domain]  Cd Length: 145  Bit Score: 66.78  E-value: 2.56e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51338761  50 KTLFILRGLPGSGKSTLARlileKYHDGTKMVSADAY----KIIPGSRADFSEAYKRLDEDLAGYCRRDiRVLVLDDTNH 125
Cdd:COG4639   2 LSLVVLIGLPGSGKSTFAR----RLFAPTEVVSSDDIrallGGDENDQSAWGDVFQLAHEIARARLRAG-RLTVVDATNL 76

                        90       100
                ....*....|....*....|..
gi 51338761 126 ERERLDQLFEMADQYQYQVVLV 147
Cdd:COG4639  77 QREARRRLLALARAYGALVVAV 98
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 52-165 1.75e-09

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 55.78  E-value: 1.75e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51338761    52 LFILRGLPGSGKSTLARLILEKYhdGTKMVSADAY---------KIIPGSRADFSEAYKRLDEDLAGYCRRDIRVlVLDD 122
Cdd:pfam13671   1 LILLVGLPGSGKSTLARRLLEEL--GAVRLSSDDErkrlfgegrPSISYYTDATDRTYERLHELARIALRAGRPV-ILDA 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 51338761   123 TN---HERERLDQLFEmadQYQYQVVLVEPKTAWrldcAQLKEKNQ 165
Cdd:pfam13671  78 TNlrrDERARLLALAR---EYGVPVRIVVFEAPE----EVLRERLA 116
pseT PHA02530
polynucleotide kinase; Provisional
 50-147 1.25e-05

polynucleotide kinase; Provisional


Pssm-ID: 222856 [Multi-domain]  Cd Length: 300  Bit Score: 46.55  E-value: 1.25e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51338761   50 KTLFILRGLPGSGKSTLARLILEKyHDGTKMVSADAYKII---PGSRADFSeaYKRLDEDLAGYCRRDIRVL-------- 118
Cdd:PHA02530   2 MKIILTVGVPGSGKSTWAREFAAK-NPKAVNVNRDDLRQSlfgHGEWGEYK--FTKEKEDLVTKAQEAAALAalksgksv 78

                         90       100
                 ....*....|....*....|....*....
gi 51338761  119 VLDDTNHERERLDQLFEMADQYQYQVVLV 147
Cdd:PHA02530  79 IISDTNLNPERRRKWKELAKELGAEFEEK 107
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 54-122 2.90e-04

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 40.82  E-value: 2.90e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51338761     54 ILRGLPGSGKSTLARLI---LEKYHDGTKMVSADAY---------KIIPGSRADFSEAYKRLDEDLAGYCRRDIRVLVLD 121
Cdd:smart00382   6 LIVGPPGSGKTTLARALareLGPPGGGVIYIDGEDIleevldqllLIIVGGKKASGSGELRLRLALALARKLKPDVLILD 85


                   .
gi 51338761    122 D 122
Cdd:smart00382  86 E 86
 
Name Accession Description Interval E-value
CNPase pfam05881
2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP or CNPase); This family consists of the ...
 185-398 2.59e-147

2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP or CNPase); This family consists of the eukaryotic protein 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP). 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP) is one of the earliest myelin-related proteins expressed in differentiating oligodendrocytes and Schwann cells. CNP is abundant in the central nervous system and in oligodendrocytes. This protein is also found in mammalian photoreceptor cells, testis and lymphocytes. Although the biological function of CNP is unknown, it is thought to play a significant role in the formation of the myelin sheath, where it comprises 4% of total protein. CNP selectively cleaves 2',3'-cyclic nucleotides to produce 2'-nucleotides in vitro. Although physiologically relevant substrates with 2',3'-cyclic termini are still unknown, numerous cyclic phosphate containing RNAs occur transiently within eukaryotic cells. Other known protein families capable of hydrolysing 2',3'-cyclic nucleotides include tRNA ligases and plant cyclic phosphodiesterases. The catalytic domains from all these proteins contain two tetra-peptide motifs H-X-T/S-X, where X is usually a hydrophobic residue. Mutation of either histidine in CNP abolishes enzymatic activity. CNPases belong to the 2H phosphoesterase superfamily. They share a common active site, characterized by two conserved histidines, with the bacterial tRNA-ligating enzyme LigT, vertebrate myelin-associated 2',3' phosphodiesterases, plant Arabidopsis thaliana CPDases and several several bacteria and virus proteins.


Pssm-ID: 461769  Cd Length: 214  Bit Score: 416.93  E-value: 2.59e-147
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51338761   185 LPLYFGWFLTKKSSETLRKAGQVFLEELGNHKAFKKELRHFISGDEPKEKLELVSYFGKRPPGVLHCTTKFCDYGKAAGA 264
Cdd:pfam05881   1 LPLYFGWFLTKKSSEALRKTGQVFLEELGNHKAFKKELRHFQSGDEPKEKIDLTSYFGKRPPGVLHCTTKFCDYGKAPGA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51338761   265 EEYAQQEVVKRSYGKAFKLSISALFVTPKTAGAQVVLTDQELQLWPSDLDKPSASEGLPPGSRAHVTLGCAADVQPVQTG 344
Cdd:pfam05881  81 EEYAQQDVVKKSYGKAFTLSISALFVTPKTVGARVELNEQQLALWPADVDKLSPSDSLPKGSRAHVTLGCASDVEAVQTG 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 51338761   345 LDLLDILQQVKGGSQGEAVGELPRGKLYSLGKGRWMLSLTKKMEVKAIFTGYYG 398
Cdd:pfam05881 161 LDLLEIVKLEKGGSQGEEVGELGRGKLQSLGNGRWMLSLAKKIEVRAIFSGYYG 214
COG4639 COG4639
Predicted kinase [General function prediction only];
50-147 2.56e-13

Predicted kinase [General function prediction only];


Pssm-ID: 443677 [Multi-domain]  Cd Length: 145  Bit Score: 66.78  E-value: 2.56e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51338761  50 KTLFILRGLPGSGKSTLARlileKYHDGTKMVSADAY----KIIPGSRADFSEAYKRLDEDLAGYCRRDiRVLVLDDTNH 125
Cdd:COG4639   2 LSLVVLIGLPGSGKSTFAR----RLFAPTEVVSSDDIrallGGDENDQSAWGDVFQLAHEIARARLRAG-RLTVVDATNL 76

                        90       100
                ....*....|....*....|..
gi 51338761 126 ERERLDQLFEMADQYQYQVVLV 147
Cdd:COG4639  77 QREARRRLLALARAYGALVVAV 98
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 52-165 1.75e-09

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 55.78  E-value: 1.75e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51338761    52 LFILRGLPGSGKSTLARLILEKYhdGTKMVSADAY---------KIIPGSRADFSEAYKRLDEDLAGYCRRDIRVlVLDD 122
Cdd:pfam13671   1 LILLVGLPGSGKSTLARRLLEEL--GAVRLSSDDErkrlfgegrPSISYYTDATDRTYERLHELARIALRAGRPV-ILDA 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 51338761   123 TN---HERERLDQLFEmadQYQYQVVLVEPKTAWrldcAQLKEKNQ 165
Cdd:pfam13671  78 TNlrrDERARLLALAR---EYGVPVRIVVFEAPE----EVLRERLA 116
Kti12 COG4088
tRNA uridine 5-carbamoylmethylation protein Kti12 (Killer toxin insensitivity protein) ...
 51-149 6.81e-07

tRNA uridine 5-carbamoylmethylation protein Kti12 (Killer toxin insensitivity protein) [Translation, ribosomal structure and biogenesis, Defense mechanisms];


Pssm-ID: 443264 [Multi-domain]  Cd Length: 179  Bit Score: 49.34  E-value: 6.81e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51338761  51 TLFILRGLPGSGKSTLARLI---LEKYHDGTKMVSADAYKIIPGSRADFSEAYKRLDEDLAGYCRRDIR----VLVLDDT 123
Cdd:COG4088   5 MLLILTGPPGSGKTTFAKALaqrLYAEGIAVALLHSDDFRRFLVNESFPKETYEEVVEDVRTTTADNALdngySVIVDGT 84

                        90       100
                ....*....|....*....|....*..
gi 51338761 124 NHERERLDQLFEMA-DQYQYQVVLVEP 149
Cdd:COG4088  85 FYYRSWQRDFRNLAkHKAPIHIIYLKA 111
COG0645 COG0645
Predicted kinase, contains AAA domain [General function prediction only];
52-148 8.25e-07

Predicted kinase, contains AAA domain [General function prediction only];


Pssm-ID: 440410 [Multi-domain]  Cd Length: 164  Bit Score: 48.76  E-value: 8.25e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51338761  52 LFILRGLPGSGKSTLARLILEKYhdGTKMVSADA-----YKIIPGSRADFSEA----YKRLDEDLAGYCRRDIRVlVLDD 122
Cdd:COG0645   1 LILVCGLPGSGKSTLARALAERL--GAVRLRSDVvrkrlFGAGLAPLERSPEAtartYARLLALARELLAAGRSV-ILDA 77

                        90       100
                ....*....|....*....|....*.
gi 51338761 123 TNHERERLDQLFEMADQYQYQVVLVE 148
Cdd:COG0645  78 TFLRRAQREAFRALAEEAGAPFVLIW 103
pseT PHA02530
polynucleotide kinase; Provisional
 50-147 1.25e-05

polynucleotide kinase; Provisional


Pssm-ID: 222856 [Multi-domain]  Cd Length: 300  Bit Score: 46.55  E-value: 1.25e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51338761   50 KTLFILRGLPGSGKSTLARLILEKyHDGTKMVSADAYKII---PGSRADFSeaYKRLDEDLAGYCRRDIRVL-------- 118
Cdd:PHA02530   2 MKIILTVGVPGSGKSTWAREFAAK-NPKAVNVNRDDLRQSlfgHGEWGEYK--FTKEKEDLVTKAQEAAALAalksgksv 78

                         90       100
                 ....*....|....*....|....*....
gi 51338761  119 VLDDTNHERERLDQLFEMADQYQYQVVLV 147
Cdd:PHA02530  79 IISDTNLNPERRRKWKELAKELGAEFEEK 107
PRK04182 PRK04182
cytidylate kinase; Provisional
 57-83 2.82e-04

cytidylate kinase; Provisional


Pssm-ID: 235244 [Multi-domain]  Cd Length: 180  Bit Score: 41.33  E-value: 2.82e-04
                         10        20
                 ....*....|....*....|....*..
gi 51338761   57 GLPGSGKSTLARLILEKYhdGTKMVSA 83
Cdd:PRK04182   7 GPPGSGKTTVARLLAEKL--GLKHVSA 31
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 54-122 2.90e-04

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 40.82  E-value: 2.90e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51338761     54 ILRGLPGSGKSTLARLI---LEKYHDGTKMVSADAY---------KIIPGSRADFSEAYKRLDEDLAGYCRRDIRVLVLD 121
Cdd:smart00382   6 LIVGPPGSGKTTLARALareLGPPGGGVIYIDGEDIleevldqllLIIVGGKKASGSGELRLRLALALARKLKPDVLILD 85


                   .
gi 51338761    122 D 122
Cdd:smart00382  86 E 86
AAA_18 pfam13238
AAA domain;
54-154 3.50e-04

AAA domain;


Pssm-ID: 433052 [Multi-domain]  Cd Length: 128  Bit Score: 40.10  E-value: 3.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51338761    54 ILRGLPGSGKSTLARLILEKYHDGTKMVSADAYKIIPGSRADFSEAYKRLDEDLAGYCRRDIR---------VLVLDDTn 124
Cdd:pfam13238   2 LITGTPGVGKTTLAKELSKRLGFGDNVRDLALENGLVLGDDPETRESKRLDEDKLDRLLDLLEenaaleeggNLIIDGH- 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 51338761   125 hereRLDQLFEMADQYQYQVVLVEPKTAWR 154
Cdd:pfam13238  81 ----LAELEPERAKDLVGIVLRASPEELLE 106
PRK06762 PRK06762
hypothetical protein; Provisional
 51-84 7.99e-04

hypothetical protein; Provisional


Pssm-ID: 235858  Cd Length: 166  Bit Score: 39.95  E-value: 7.99e-04
                         10        20        30
                 ....*....|....*....|....*....|....
gi 51338761   51 TLFILRGLPGSGKSTLARLILEKYHDGTKMVSAD 84
Cdd:PRK06762   3 TLIIIRGNSGSGKTTIAKQLQERLGRGTLLVSQD 36
COG4185 COG4185
Predicted ABC-type ATPase or kinase [General function prediction only];
50-85 3.39e-03

Predicted ABC-type ATPase or kinase [General function prediction only];


Pssm-ID: 443339  Cd Length: 197  Bit Score: 38.33  E-value: 3.39e-03
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 51338761  50 KTLFILRGLPGSGKSTLARLILEKYHDGTKMVSADA 85
Cdd:COG4185   4 PRLYIIAGPNGAGKSTFARTILPEELGGLEFVNADL 39
AAA_17 pfam13207
AAA domain;
57-83 7.40e-03

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 36.45  E-value: 7.40e-03
                          10        20
                  ....*....|....*....|....*..
gi 51338761    57 GLPGSGKSTLARLILEKYhdGTKMVSA 83
Cdd:pfam13207   2 GVPGSGKTTQLKKLAEKL--GFPHISA 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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