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RecName: Full=Endoplasmin; AltName: Full=94 kDa glucose-regulated protein; Short=GRP-94; AltName: Full=Heat shock protein 90 kDa beta member 1; AltName: Full=Heat shock protein family C member 4; AltName: Full=Tumor rejection antigen 1; AltName: Full=gp96 homolog; Flags: Precursor
Protein Classification
List of domain hits
Name
Accession
Description
Interval
E-value
HSP90
pfam00183 Hsp90 protein;
257-755
0e+00
Hsp90 protein;
Pssm-ID: 459703
Cd Length: 516
Bit Score: 780.97
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 257 D YLE LDT IK N LVKKYS Q FINFPIY V W SS K T E T V - EEPM EEEE AAK EE K EE S DD EAAV EE E EEE K K P KTKKV EK TVW D WEL 335
Cdd:pfam00183 1 E YLE EKK IK E LVKKYS E FINFPIY L W VE K E E E V e VPDE EEEE EEE EE E EE D DD PKVE EE D EEE E K K KTKKV KE TVW E WEL 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 336 M N DI KPIW Q R PS KEV E E D EY KA FYKS F SK ESD DP M A YI HF TA EGEV T FKS I LF V P TS AP RG LF DEY gs KK SDY IKLYVRR 415
Cdd:pfam00183 81 L N KT KPIW T R NP KEV T E E EY AE FYKS L SK DWE DP L A VK HF SV EGEV E FKS L LF I P KR AP FD LF ENK -- KK KNN IKLYVRR 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 416 VFITDDF H D MM P K YLNFVKGVVDSDDLPLNVSRETLQQ H K L LKVI R KKLVRK T LDM I K K IA DD K YN - DT FWKEFG T N I KL 494
Cdd:pfam00183 159 VFITDDF E D LI P E YLNFVKGVVDSDDLPLNVSRETLQQ N K I LKVI K KKLVRK A LDM F K E IA EE K ED y KK FWKEFG K N L KL 238
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 495 G V IED H SNR TR LAKLLRF Q SS HHPTDI TSLD Q YV E RMKE K Q DK IY FMA G S S RK E A E S SPF V ERL L KKGYEV I YLT E P V DE 574
Cdd:pfam00183 239 G I IED S SNR NK LAKLLRF Y SS KSGDEL TSLD D YV S RMKE G Q KH IY YIT G E S KE E V E N SPF L ERL K KKGYEV L YLT D P I DE 318
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 575 Y CI Q A L P EFDGK RFQ NVAKEG VKFD E S E KT K ESR E AVE KEFEPL LN W M KD k A L K DK I EK A VVS Q RL TE SPC A LV A SQYGW 654
Cdd:pfam00183 319 Y AV Q Q L K EFDGK KLV NVAKEG LELE E D E EE K KKD E ELK KEFEPL TK W L KD - V L G DK V EK V VVS N RL VD SPC V LV T SQYGW 397
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 655 S G NMERIMKAQA YQ tg KD I S TNY Y A S Q KKT F EINPRHP L I RDM L R R IKE D E DDKT VL DLA VV L F ETA T LRSG YL L P D TKA 734
Cdd:pfam00183 398 S A NMERIMKAQA LR -- KD S S MSS Y M S S KKT L EINPRHP I I KEL L K R VEA D K DDKT AK DLA LL L Y ETA L LRSG FS L E D PAS 475
490 500
....*....|....*....|.
gi 119360 735 YGD RI E RML R L S L N ID P D AK V 755
Cdd:pfam00183 476 FAS RI Y RML K L G L G ID E D EI V 496
HATPase_Hsp90-like
cd16927 Histidine kinase-like ATPase domain of human cytosolic Hsp90 and its homologs including ...
83-275
9.03e-99
Histidine kinase-like ATPase domain of human cytosolic Hsp90 and its homologs including Escherichia coli HtpG, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of 90 kilodalton heat-shock protein (Hsp90) eukaryotic homologs including cytosolic Hsp90, mitochondrial TRAP1 (tumor necrosis factor receptor-associated protein 1), GRP94 (94 kDa glucose-regulated protein) of the endoplasmic reticulum (ER), and chloroplast Hsp90C. It also includes the bacterial homologs of Hsp90, known as HtpG (High temperature protein G). Hsp90 family of chaperones assist other proteins to fold correctly, stabilizes them against heat stress, and aids in protein degradation.
Pssm-ID: 340404 [Multi-domain]
Cd Length: 189
Bit Score: 304.06
E-value: 9.03e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 83 N RMMK LII N SLY K NKEIFLRELISNASDALDK I R LI SLTD ENA L SGNE EL TVK I KC DKE KNL L HVT DTG V GMT R EEL VK N 162
Cdd:cd16927 1 N QLLD LII H SLY S NKEIFLRELISNASDALDK L R YL SLTD PSL L DDDP EL EIR I SP DKE NRT L TIS DTG I GMT K EEL IN N 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 163 LGTIA K SGT SE FL NKMT E AQE D gqst S E LIGQFGVGFYSAF L VADKV I VT S K HN - N D TQHI WESD SNEFSV I ADPR G N t L 241
Cdd:cd16927 81 LGTIA R SGT KA FL EALQ E GAK D ---- S D LIGQFGVGFYSAF M VADKV T VT T K SA g D D EGYR WESD GGGSYT I EEAE G E - L 155
170 180 190
....*....|....*....|....*....|....
gi 119360 242 GRGT T ITL V LKE E A SDY LE LDT IK N LVKKYS Q FI 275
Cdd:cd16927 156 GRGT K ITL H LKE D A KEF LE EAR IK E LVKKYS D FI 189
Name
Accession
Description
Interval
E-value
HSP90
pfam00183 Hsp90 protein;
257-755
0e+00
Hsp90 protein;
Pssm-ID: 459703
Cd Length: 516
Bit Score: 780.97
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 257 D YLE LDT IK N LVKKYS Q FINFPIY V W SS K T E T V - EEPM EEEE AAK EE K EE S DD EAAV EE E EEE K K P KTKKV EK TVW D WEL 335
Cdd:pfam00183 1 E YLE EKK IK E LVKKYS E FINFPIY L W VE K E E E V e VPDE EEEE EEE EE E EE D DD PKVE EE D EEE E K K KTKKV KE TVW E WEL 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 336 M N DI KPIW Q R PS KEV E E D EY KA FYKS F SK ESD DP M A YI HF TA EGEV T FKS I LF V P TS AP RG LF DEY gs KK SDY IKLYVRR 415
Cdd:pfam00183 81 L N KT KPIW T R NP KEV T E E EY AE FYKS L SK DWE DP L A VK HF SV EGEV E FKS L LF I P KR AP FD LF ENK -- KK KNN IKLYVRR 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 416 VFITDDF H D MM P K YLNFVKGVVDSDDLPLNVSRETLQQ H K L LKVI R KKLVRK T LDM I K K IA DD K YN - DT FWKEFG T N I KL 494
Cdd:pfam00183 159 VFITDDF E D LI P E YLNFVKGVVDSDDLPLNVSRETLQQ N K I LKVI K KKLVRK A LDM F K E IA EE K ED y KK FWKEFG K N L KL 238
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 495 G V IED H SNR TR LAKLLRF Q SS HHPTDI TSLD Q YV E RMKE K Q DK IY FMA G S S RK E A E S SPF V ERL L KKGYEV I YLT E P V DE 574
Cdd:pfam00183 239 G I IED S SNR NK LAKLLRF Y SS KSGDEL TSLD D YV S RMKE G Q KH IY YIT G E S KE E V E N SPF L ERL K KKGYEV L YLT D P I DE 318
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 575 Y CI Q A L P EFDGK RFQ NVAKEG VKFD E S E KT K ESR E AVE KEFEPL LN W M KD k A L K DK I EK A VVS Q RL TE SPC A LV A SQYGW 654
Cdd:pfam00183 319 Y AV Q Q L K EFDGK KLV NVAKEG LELE E D E EE K KKD E ELK KEFEPL TK W L KD - V L G DK V EK V VVS N RL VD SPC V LV T SQYGW 397
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 655 S G NMERIMKAQA YQ tg KD I S TNY Y A S Q KKT F EINPRHP L I RDM L R R IKE D E DDKT VL DLA VV L F ETA T LRSG YL L P D TKA 734
Cdd:pfam00183 398 S A NMERIMKAQA LR -- KD S S MSS Y M S S KKT L EINPRHP I I KEL L K R VEA D K DDKT AK DLA LL L Y ETA L LRSG FS L E D PAS 475
490 500
....*....|....*....|.
gi 119360 735 YGD RI E RML R L S L N ID P D AK V 755
Cdd:pfam00183 476 FAS RI Y RML K L G L G ID E D EI V 496
PRK05218
PRK05218 heat shock protein 90; Provisional
74-746
0e+00
heat shock protein 90; Provisional
Pssm-ID: 235366 [Multi-domain]
Cd Length: 613
Bit Score: 714.58
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 74 E KFA FQAEV NRMMK L I I N SLY K NKEIFLRELISNASDA L DK I R LIS LTD ENALS G NEE L TVK I KC DKE KNL L HVT D T G V G 153
Cdd:PRK05218 4 E TGE FQAEV KQLLH L M I H SLY S NKEIFLRELISNASDA I DK L R FEA LTD PALYE G DGD L KIR I SF DKE ART L TIS D N G I G 83
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 154 MTREE LVK NLGTIAKSGT S EFL N K MTEA Q EDG qst S E LIGQFGVGFYSAF L VADKV I V TSKH -- NNDTQHI WESD - SN E F 230
Cdd:PRK05218 84 MTREE VIE NLGTIAKSGT K EFL E K LKGD Q KKD --- S Q LIGQFGVGFYSAF M VADKV T V ITRS ag PAAEAVR WESD g EG E Y 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 231 S v I ADPRGNT lg RGT T ITL V LKE EASDY L ELDT I KNLV KKYS Q FI NF PI YVW ssktetveepmeeeeaakeekeesddea 310
Cdd:PRK05218 161 T - I EEIEKEE -- RGT E ITL H LKE DEDEF L DEWR I RSII KKYS D FI PV PI KLE ---------------------------- 209
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 311 aveeeeeekkpktkkvekt VWDW E LM N DIKPI W Q R PSK E VEED EYK A FYK SFSKES DDP MAY IH FTA EG EVTFKSI L FV P 390
Cdd:PRK05218 210 ------------------- KEEE E TI N SASAL W T R SKS E ITDE EYK E FYK HLAHDF DDP LFW IH NNV EG PFEYTGL L YI P 270
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 391 TS AP RG LF D - EYGSK ksdy I KLYV R RVFI T DD FHDMM P K YL N FVKGV V DS D DLPLNVSRE T LQ QHKLL K V IRK KLVR K T L 469
Cdd:PRK05218 271 KK AP FD LF N r DRKGG ---- L KLYV K RVFI M DD AEELL P E YL R FVKGV I DS E DLPLNVSRE I LQ EDRVV K K IRK AITK K V L 346
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 470 D MIK K I A DD --- KY N d T FWKEFG TNI K L G VI ED HS NR TR LAKLLRF Q S S H H p TDIT SL DQ YVERMKE K Q D KIY FMA G S SR 546
Cdd:PRK05218 347 D ELE K L A KN dre KY E - K FWKEFG PVL K E G LY ED FA NR EK LAKLLRF A S T H E - GKYV SL AE YVERMKE G Q K KIY YIT G D SR 424
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 547 KE A ES SP FV E RLL KKG Y EV IY LT E P V DE YC I QA L P EFDGK R F QN VA KEGVKFD - E S E KT KE SR E AV E K EF E PLL NWM K d K 625
Cdd:PRK05218 425 EA A KN SP HL E LFK KKG I EV LL LT D P I DE FW I SY L E EFDGK P F KS VA RGDLDLG k E D E EE KE EK E EA E E EF K PLL ERL K - E 503
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 626 AL K DK IEKAVV S Q RLT E SP CA LVA SQYGW S GN ME RIM K a Q A Y Q TGKDI stnyyasq K KTF EINP R HPL I rdml RRIKEDE 705
Cdd:PRK05218 504 AL G DK VKDVRL S H RLT D SP AC LVA DEGDM S TQ ME KLL K - A A G Q EVPES -------- K PIL EINP N HPL V ---- KKLADEA 570
650 660 670 680
....*....|....*....|....*....|....*....|..
gi 119360 706 D DKTVL DLA VV L FET A T L RS G YL L P D TK A YGD R I - E RM L R L S 746
Cdd:PRK05218 571 D EAKFK DLA EL L YDQ A L L AE G GS L E D PA A FVK R L n E LL L K L L 612
HtpG
COG0326 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, ...
72-748
0e+00
Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440095 [Multi-domain]
Cd Length: 616
Bit Score: 713.43
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 72 KS E KFA FQAEV NRMMK L I I N SLY K NKEIFLRELISNASDA L DK I R LIS LTD ENALSGNEE L TVK I KC DKE KNL L HVT D T G 151
Cdd:COG0326 2 AK E TGE FQAEV KQLLD L M I H SLY S NKEIFLRELISNASDA I DK L R FLA LTD PELKEEDGD L KIR I EV DKE AKT L TIS D N G 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 152 V GMTREE LVK NLGTIAKSGT S EFL N K MTEA Q EDG qst S E LIGQFGVGFYSAF L VADKV I V TSK - HNN D TQ - HI WESD - SN 228
Cdd:COG0326 82 I GMTREE VIE NLGTIAKSGT R EFL E K LKGD Q KKD --- S D LIGQFGVGFYSAF M VADKV E V VTR s AGE D AE a VR WESD g DG 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 229 E FSVIADPR gnt LG RGT T ITL V LKE E A SDY LE LDTIKNLV KKYS Q FI NF PI YVWSSKT ET V eepmeeeeaakeekeesdd 308
Cdd:COG0326 159 E YTIEEAEK --- AE RGT E ITL H LKE D A EEF LE EWRLREII KKYS D FI PV PI KMEGEEE ET E ------------------- 216
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 309 eaaveeeeeekkpktkkvektvw DW E LM N DIKPI W Q R PSK E VEED EYK A FYK SFSKESD DP MAY IH FTA EG EVTFKSI L F 388
Cdd:COG0326 217 ----------------------- ED E TI N SATAL W T R SKS E ITDE EYK E FYK HLFHDFE DP LFW IH LNV EG PFEYTGL L Y 273
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 389 V P TS AP RG L F D EYGSKK sdy IKLYV R RVFI T DD FH D MM P K YL N FV K GVVDS D DLPLNVSRE T LQ QHKL LK V IRK KLVR K T 468
Cdd:COG0326 274 I P KK AP FD L Y D RDRKGG --- IKLYV K RVFI M DD AE D LL P E YL R FV R GVVDS P DLPLNVSRE I LQ EDRQ LK K IRK AITK K V 350
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 469 LD MIK K I A DD --- KY N d T FWKEFG TNI K L G VI ED HS NR TRL A K LLRF Q S SH h PTDITS L DQ YVERMKE K Q D KIY FMA G S S 545
Cdd:COG0326 351 LD ELE K L A KN dre KY E - K FWKEFG LVL K E G AL ED FK NR EKI A D LLRF E S TK - EGGYVT L AE YVERMKE G Q K KIY YIT G E S 428
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 546 R KE AE S SP FV E RLLK KG Y EV IY LT E P V DE YC I QA L P EFDGK R F QN V AKEGVKF D ES E KT KES r E AV E K EF E PLL NWM K d K 625
Cdd:COG0326 429 R EA AE Q SP HL E IFKA KG I EV LL LT D P I DE FL I SH L E EFDGK K F KS V DSGDLDL D KL E EK KES - E EE E E EF K PLL ERF K - E 506
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 626 AL K DK IEKAV VS Q RLT E SP CA LVA SQYGW S GN ME RIM KA Q ayqt G K D IS tnyya SQ K KTF EINP R HPL I rdml RRIKED E 705
Cdd:COG0326 507 AL G DK VKDVR VS A RLT D SP AC LVA DEGDM S RR ME KML KA M ---- G Q D MP ----- EA K PIL EINP N HPL V ---- KKLAAE E 573
650 660 670 680
....*....|....*....|....*....|....*....|...
gi 119360 706 D DKTVL DLA VV L FET A T L RS G Y LL P D TK A YGD R IERM L RLS L N 748
Cdd:COG0326 574 D EELFK DLA EL L YDQ A L L AE G G LL E D PA A FVK R LNKL L EKA L G 616
HATPase_Hsp90-like
cd16927 Histidine kinase-like ATPase domain of human cytosolic Hsp90 and its homologs including ...
83-275
9.03e-99
Histidine kinase-like ATPase domain of human cytosolic Hsp90 and its homologs including Escherichia coli HtpG, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of 90 kilodalton heat-shock protein (Hsp90) eukaryotic homologs including cytosolic Hsp90, mitochondrial TRAP1 (tumor necrosis factor receptor-associated protein 1), GRP94 (94 kDa glucose-regulated protein) of the endoplasmic reticulum (ER), and chloroplast Hsp90C. It also includes the bacterial homologs of Hsp90, known as HtpG (High temperature protein G). Hsp90 family of chaperones assist other proteins to fold correctly, stabilizes them against heat stress, and aids in protein degradation.
Pssm-ID: 340404 [Multi-domain]
Cd Length: 189
Bit Score: 304.06
E-value: 9.03e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 83 N RMMK LII N SLY K NKEIFLRELISNASDALDK I R LI SLTD ENA L SGNE EL TVK I KC DKE KNL L HVT DTG V GMT R EEL VK N 162
Cdd:cd16927 1 N QLLD LII H SLY S NKEIFLRELISNASDALDK L R YL SLTD PSL L DDDP EL EIR I SP DKE NRT L TIS DTG I GMT K EEL IN N 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 163 LGTIA K SGT SE FL NKMT E AQE D gqst S E LIGQFGVGFYSAF L VADKV I VT S K HN - N D TQHI WESD SNEFSV I ADPR G N t L 241
Cdd:cd16927 81 LGTIA R SGT KA FL EALQ E GAK D ---- S D LIGQFGVGFYSAF M VADKV T VT T K SA g D D EGYR WESD GGGSYT I EEAE G E - L 155
170 180 190
....*....|....*....|....*....|....
gi 119360 242 GRGT T ITL V LKE E A SDY LE LDT IK N LVKKYS Q FI 275
Cdd:cd16927 156 GRGT K ITL H LKE D A KEF LE EAR IK E LVKKYS D FI 189
PRK14083
PRK14083 HSP90 family protein; Provisional
77-464
1.09e-27
HSP90 family protein; Provisional
Pssm-ID: 237603 [Multi-domain]
Cd Length: 601
Bit Score: 118.89
E-value: 1.09e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 77 A FQ AEVNRMMK L IINS LY KNKEIFL REL IS NA S DA ldk I RLISLT D EN A lsg NEELTVKIKCDKEKN L L h V T D T G V G M T R 156
Cdd:PRK14083 4 R FQ VDLRGVID L LSRH LY SSPRVYV REL LQ NA V DA --- I TARRAL D PT A --- PGRIRIELTDAGGGT L I - V E D N G I G L T E 76
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 157 EE LVKN L G TI AK S GTSE flnkmtea QED G QSTSELI GQFG V G FY S A FLVAD KVI V T S KHNN D TQHI - W -- ES D SN e F SV I 233
Cdd:PRK14083 77 EE VHEF L A TI GR S SKRD -------- ENL G FARNDFL GQFG I G LL S C FLVAD EIV V V S RSAK D GPAV e W rg KA D GT - Y SV R 147
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 234 ADP r GNTLGR GTT IT L VLKEE A SDY LE LD T IKN L V KKY SQFINF PI Y V wssktetveepmeeeeaakeekeesddeaave 313
Cdd:PRK14083 148 KLE - TERAEP GTT VY L RPRPD A EEW LE RE T VEE L A KKY GSLLPV PI R V -------------------------------- 194
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 314 eeeeekkpktkkvekt VWDWELM N DIK P I W Q R -- P SK E VEEDEYK A FYKS - FSKE sdd P MAY I HFTAEGEVTF k SILF V - 389
Cdd:PRK14083 195 ---------------- EGEKGGV N ETP P P W T R dy P DP E TRREALL A YGEE l LGFT --- P LDV I PLDVPSGGLE - GVAY V l 254
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 119360 390 P TSAP rglfde YGSKKSD yi KL Y VR R VFITDDFHDMM P KYLN FV KG VV DS D D L PLNV SRE T L QQHKL L KVI R KK L 464
Cdd:PRK14083 255 P YAVS ------ PAARRKH -- RV Y LK R MLLSEEAENLL P DWAF FV RC VV NT D E L RPTA SRE A L YEDDA L AAV R EE L 321
HATPase_c
smart00387 Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
96-254
5.09e-09
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain]
Cd Length: 111
Bit Score: 54.58
E-value: 5.09e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 96 NKEIF LR ELI SN AS D aldkirlisltde NA L --- SGNEEL TV KIKC D KEKNLLH V T D T G V G MTR E E lvknlgtiaksgts 172
Cdd:smart00387 1 GDPDR LR QVL SN LL D ------------- NA I kyt PEGGRI TV TLER D GDHVEIT V E D N G P G IPP E D -------------- 53
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 173 ef L N K MT E AQEDGQST S EL IG QF G V G FYSAFLVADKVIVTSKHN ndtqhiwesdsnefsviadprg NTL G R GTT I T LV L K 252
Cdd:smart00387 54 -- L E K IF E PFFRTDKR S RK IG GT G L G LSIVKKLVELHGGEISVE ---------------------- SEP G G GTT F T IT L P 109
..
gi 119360 253 E E 254
Cdd:smart00387 110 L E 111
HATPase_c_3
pfam13589 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, ...
124-222
8.41e-06
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 433332 [Multi-domain]
Cd Length: 135
Bit Score: 46.17
E-value: 8.41e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 124 N ALSGNEE l TV KI KCD K EKNL --- LHVT D T G V GM TR EEL VKN L G t I A K S gtsefl N K MTEAQEDG qstsel I G QF G V G FY 200
Cdd:pfam13589 11 N SIDADAT - NI KI EVN K NRGG gte IVIE D D G H GM SP EEL INA L R - L A T S ------ A K EAKRGSTD ------ L G RY G I G LK 76
90 100
....*....|....*....|...
gi 119360 201 S A F L V - AD K VI VTSK HNNDTQHI 222
Cdd:pfam13589 77 L A S L S l GA K LT VTSK KEGKSSTL 99
KinB
COG5806 Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ...
125-165
1.92e-03
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain]
Cd Length: 412
Bit Score: 41.39
E-value: 1.92e-03
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 119360 125 A LSGNEE LT VKIKC DK E K NLLHVT DTGVGMT R E E L v KN LG T 165
Cdd:COG5806 326 A MPNGGT LT IDVSI DK N K VIISIK DTGVGMT K E Q L - ER LG E 365
Name
Accession
Description
Interval
E-value
HSP90
pfam00183 Hsp90 protein;
257-755
0e+00
Hsp90 protein;
Pssm-ID: 459703
Cd Length: 516
Bit Score: 780.97
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 257 D YLE LDT IK N LVKKYS Q FINFPIY V W SS K T E T V - EEPM EEEE AAK EE K EE S DD EAAV EE E EEE K K P KTKKV EK TVW D WEL 335
Cdd:pfam00183 1 E YLE EKK IK E LVKKYS E FINFPIY L W VE K E E E V e VPDE EEEE EEE EE E EE D DD PKVE EE D EEE E K K KTKKV KE TVW E WEL 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 336 M N DI KPIW Q R PS KEV E E D EY KA FYKS F SK ESD DP M A YI HF TA EGEV T FKS I LF V P TS AP RG LF DEY gs KK SDY IKLYVRR 415
Cdd:pfam00183 81 L N KT KPIW T R NP KEV T E E EY AE FYKS L SK DWE DP L A VK HF SV EGEV E FKS L LF I P KR AP FD LF ENK -- KK KNN IKLYVRR 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 416 VFITDDF H D MM P K YLNFVKGVVDSDDLPLNVSRETLQQ H K L LKVI R KKLVRK T LDM I K K IA DD K YN - DT FWKEFG T N I KL 494
Cdd:pfam00183 159 VFITDDF E D LI P E YLNFVKGVVDSDDLPLNVSRETLQQ N K I LKVI K KKLVRK A LDM F K E IA EE K ED y KK FWKEFG K N L KL 238
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 495 G V IED H SNR TR LAKLLRF Q SS HHPTDI TSLD Q YV E RMKE K Q DK IY FMA G S S RK E A E S SPF V ERL L KKGYEV I YLT E P V DE 574
Cdd:pfam00183 239 G I IED S SNR NK LAKLLRF Y SS KSGDEL TSLD D YV S RMKE G Q KH IY YIT G E S KE E V E N SPF L ERL K KKGYEV L YLT D P I DE 318
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 575 Y CI Q A L P EFDGK RFQ NVAKEG VKFD E S E KT K ESR E AVE KEFEPL LN W M KD k A L K DK I EK A VVS Q RL TE SPC A LV A SQYGW 654
Cdd:pfam00183 319 Y AV Q Q L K EFDGK KLV NVAKEG LELE E D E EE K KKD E ELK KEFEPL TK W L KD - V L G DK V EK V VVS N RL VD SPC V LV T SQYGW 397
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 655 S G NMERIMKAQA YQ tg KD I S TNY Y A S Q KKT F EINPRHP L I RDM L R R IKE D E DDKT VL DLA VV L F ETA T LRSG YL L P D TKA 734
Cdd:pfam00183 398 S A NMERIMKAQA LR -- KD S S MSS Y M S S KKT L EINPRHP I I KEL L K R VEA D K DDKT AK DLA LL L Y ETA L LRSG FS L E D PAS 475
490 500
....*....|....*....|.
gi 119360 735 YGD RI E RML R L S L N ID P D AK V 755
Cdd:pfam00183 476 FAS RI Y RML K L G L G ID E D EI V 496
PRK05218
PRK05218 heat shock protein 90; Provisional
74-746
0e+00
heat shock protein 90; Provisional
Pssm-ID: 235366 [Multi-domain]
Cd Length: 613
Bit Score: 714.58
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 74 E KFA FQAEV NRMMK L I I N SLY K NKEIFLRELISNASDA L DK I R LIS LTD ENALS G NEE L TVK I KC DKE KNL L HVT D T G V G 153
Cdd:PRK05218 4 E TGE FQAEV KQLLH L M I H SLY S NKEIFLRELISNASDA I DK L R FEA LTD PALYE G DGD L KIR I SF DKE ART L TIS D N G I G 83
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 154 MTREE LVK NLGTIAKSGT S EFL N K MTEA Q EDG qst S E LIGQFGVGFYSAF L VADKV I V TSKH -- NNDTQHI WESD - SN E F 230
Cdd:PRK05218 84 MTREE VIE NLGTIAKSGT K EFL E K LKGD Q KKD --- S Q LIGQFGVGFYSAF M VADKV T V ITRS ag PAAEAVR WESD g EG E Y 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 231 S v I ADPRGNT lg RGT T ITL V LKE EASDY L ELDT I KNLV KKYS Q FI NF PI YVW ssktetveepmeeeeaakeekeesddea 310
Cdd:PRK05218 161 T - I EEIEKEE -- RGT E ITL H LKE DEDEF L DEWR I RSII KKYS D FI PV PI KLE ---------------------------- 209
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 311 aveeeeeekkpktkkvekt VWDW E LM N DIKPI W Q R PSK E VEED EYK A FYK SFSKES DDP MAY IH FTA EG EVTFKSI L FV P 390
Cdd:PRK05218 210 ------------------- KEEE E TI N SASAL W T R SKS E ITDE EYK E FYK HLAHDF DDP LFW IH NNV EG PFEYTGL L YI P 270
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 391 TS AP RG LF D - EYGSK ksdy I KLYV R RVFI T DD FHDMM P K YL N FVKGV V DS D DLPLNVSRE T LQ QHKLL K V IRK KLVR K T L 469
Cdd:PRK05218 271 KK AP FD LF N r DRKGG ---- L KLYV K RVFI M DD AEELL P E YL R FVKGV I DS E DLPLNVSRE I LQ EDRVV K K IRK AITK K V L 346
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 470 D MIK K I A DD --- KY N d T FWKEFG TNI K L G VI ED HS NR TR LAKLLRF Q S S H H p TDIT SL DQ YVERMKE K Q D KIY FMA G S SR 546
Cdd:PRK05218 347 D ELE K L A KN dre KY E - K FWKEFG PVL K E G LY ED FA NR EK LAKLLRF A S T H E - GKYV SL AE YVERMKE G Q K KIY YIT G D SR 424
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 547 KE A ES SP FV E RLL KKG Y EV IY LT E P V DE YC I QA L P EFDGK R F QN VA KEGVKFD - E S E KT KE SR E AV E K EF E PLL NWM K d K 625
Cdd:PRK05218 425 EA A KN SP HL E LFK KKG I EV LL LT D P I DE FW I SY L E EFDGK P F KS VA RGDLDLG k E D E EE KE EK E EA E E EF K PLL ERL K - E 503
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 626 AL K DK IEKAVV S Q RLT E SP CA LVA SQYGW S GN ME RIM K a Q A Y Q TGKDI stnyyasq K KTF EINP R HPL I rdml RRIKEDE 705
Cdd:PRK05218 504 AL G DK VKDVRL S H RLT D SP AC LVA DEGDM S TQ ME KLL K - A A G Q EVPES -------- K PIL EINP N HPL V ---- KKLADEA 570
650 660 670 680
....*....|....*....|....*....|....*....|..
gi 119360 706 D DKTVL DLA VV L FET A T L RS G YL L P D TK A YGD R I - E RM L R L S 746
Cdd:PRK05218 571 D EAKFK DLA EL L YDQ A L L AE G GS L E D PA A FVK R L n E LL L K L L 612
HtpG
COG0326 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, ...
72-748
0e+00
Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440095 [Multi-domain]
Cd Length: 616
Bit Score: 713.43
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 72 KS E KFA FQAEV NRMMK L I I N SLY K NKEIFLRELISNASDA L DK I R LIS LTD ENALSGNEE L TVK I KC DKE KNL L HVT D T G 151
Cdd:COG0326 2 AK E TGE FQAEV KQLLD L M I H SLY S NKEIFLRELISNASDA I DK L R FLA LTD PELKEEDGD L KIR I EV DKE AKT L TIS D N G 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 152 V GMTREE LVK NLGTIAKSGT S EFL N K MTEA Q EDG qst S E LIGQFGVGFYSAF L VADKV I V TSK - HNN D TQ - HI WESD - SN 228
Cdd:COG0326 82 I GMTREE VIE NLGTIAKSGT R EFL E K LKGD Q KKD --- S D LIGQFGVGFYSAF M VADKV E V VTR s AGE D AE a VR WESD g DG 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 229 E FSVIADPR gnt LG RGT T ITL V LKE E A SDY LE LDTIKNLV KKYS Q FI NF PI YVWSSKT ET V eepmeeeeaakeekeesdd 308
Cdd:COG0326 159 E YTIEEAEK --- AE RGT E ITL H LKE D A EEF LE EWRLREII KKYS D FI PV PI KMEGEEE ET E ------------------- 216
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 309 eaaveeeeeekkpktkkvektvw DW E LM N DIKPI W Q R PSK E VEED EYK A FYK SFSKESD DP MAY IH FTA EG EVTFKSI L F 388
Cdd:COG0326 217 ----------------------- ED E TI N SATAL W T R SKS E ITDE EYK E FYK HLFHDFE DP LFW IH LNV EG PFEYTGL L Y 273
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 389 V P TS AP RG L F D EYGSKK sdy IKLYV R RVFI T DD FH D MM P K YL N FV K GVVDS D DLPLNVSRE T LQ QHKL LK V IRK KLVR K T 468
Cdd:COG0326 274 I P KK AP FD L Y D RDRKGG --- IKLYV K RVFI M DD AE D LL P E YL R FV R GVVDS P DLPLNVSRE I LQ EDRQ LK K IRK AITK K V 350
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 469 LD MIK K I A DD --- KY N d T FWKEFG TNI K L G VI ED HS NR TRL A K LLRF Q S SH h PTDITS L DQ YVERMKE K Q D KIY FMA G S S 545
Cdd:COG0326 351 LD ELE K L A KN dre KY E - K FWKEFG LVL K E G AL ED FK NR EKI A D LLRF E S TK - EGGYVT L AE YVERMKE G Q K KIY YIT G E S 428
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 546 R KE AE S SP FV E RLLK KG Y EV IY LT E P V DE YC I QA L P EFDGK R F QN V AKEGVKF D ES E KT KES r E AV E K EF E PLL NWM K d K 625
Cdd:COG0326 429 R EA AE Q SP HL E IFKA KG I EV LL LT D P I DE FL I SH L E EFDGK K F KS V DSGDLDL D KL E EK KES - E EE E E EF K PLL ERF K - E 506
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 626 AL K DK IEKAV VS Q RLT E SP CA LVA SQYGW S GN ME RIM KA Q ayqt G K D IS tnyya SQ K KTF EINP R HPL I rdml RRIKED E 705
Cdd:COG0326 507 AL G DK VKDVR VS A RLT D SP AC LVA DEGDM S RR ME KML KA M ---- G Q D MP ----- EA K PIL EINP N HPL V ---- KKLAAE E 573
650 660 670 680
....*....|....*....|....*....|....*....|...
gi 119360 706 D DKTVL DLA VV L FET A T L RS G Y LL P D TK A YGD R IERM L RLS L N 748
Cdd:COG0326 574 D EELFK DLA EL L YDQ A L L AE G G LL E D PA A FVK R LNKL L EKA L G 616
PTZ00272
PTZ00272 heat shock protein 83 kDa (Hsp83); Provisional
73-754
0e+00
heat shock protein 83 kDa (Hsp83); Provisional
Pssm-ID: 240341
Cd Length: 701
Bit Score: 650.59
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 73 S E K FAFQAE V N RM M K LIIN SL Y K NKEIFLRELISNASDA L DKIR LI SLTD ENA L SGNEE L TVKIKC DKE KNL L H V T D T G V 152
Cdd:PTZ00272 2 T E T FAFQAE I N QL M S LIIN TF Y S NKEIFLRELISNASDA C DKIR YQ SLTD PSV L GESPR L CIRVVP DKE NKT L T V E D N G I 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 153 GMT REE LV K NLGTIA K SGT SE F L nkmt EA Q E D G QST S e L IGQFGVGFYSA F LVAD K V I VTSK H N N D TQHI WES DSN - E F S 231
Cdd:PTZ00272 82 GMT KAD LV N NLGTIA R SGT KA F M ---- EA L E A G GDM S - M IGQFGVGFYSA Y LVAD R V T VTSK N N S D ESYV WES SAG g T F T 156
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 232 VIAD P RGN t LG RGT T ITL V LKE EASD YLE LDTI K N L V KK Y S Q FI NFP I YVWSS KT ETV E EPM E E EE AA K EEK E -- E SDDE 309
Cdd:PTZ00272 157 ITST P ESD - MK RGT R ITL H LKE DQME YLE PRRL K E L I KK H S E FI GYD I ELMVE KT TEK E VTD E D EE DT K KAD E dg E EPKV 235
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 310 AA V E E EE E E KK P KTKKV EKTVWDW E LM N DI KP I W Q R PS K E V EED EY K AFYK SF S KESD DP M A YI HF TA EG EVT F K SI L FV 389
Cdd:PTZ00272 236 EE V K E GD E G KK K KTKKV KEVTKEY E VQ N KH KP L W T R DP K D V TKE EY A AFYK AI S NDWE DP A A TK HF SV EG QLE F R SI M FV 315
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 390 P TS AP RGL F DE yg S KK SDY IKLYVRRVFI T D DFH D MM P KY L N FVKGVVDS D DLPLN V SRE T LQQ H K L LKVIRK KL V R K T L 469
Cdd:PTZ00272 316 P KR AP FDM F EP -- N KK RNN IKLYVRRVFI M D NCE D LC P DW L G FVKGVVDS E DLPLN I SRE N LQQ N K I LKVIRK NI V K K C L 393
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 470 D M IKKI A DD K YN - DT F WKE FG T NIKLG VI ED HS NR TR L AK LLRF Q S SHHPTDI T S L DQ YV E RMK EK Q DK IY FMA G S S R K E 548
Cdd:PTZ00272 394 E M FDEV A EN K ED y KQ F YEQ FG K NIKLG IH ED TA NR KK L ME LLRF Y S TESGEEM T T L KD YV T RMK AG Q KS IY YIT G D S K K K 473
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 549 A E S SPF V E RLLKK G Y EV IYL TEP V DEY CI Q ALPE F DG K R F QNVA KEGV K F D ESE KT K ES RE AVEKEF E P L LNW MK D k A L K 628
Cdd:PTZ00272 474 L E T SPF I E QARRR G L EV LFM TEP I DEY VM Q QVKD F ED K K F ACLT KEGV H F E ESE EE K QQ RE EEKAAC E K L CKT MK E - V L G 552
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 629 DK I EK AV VS Q RL TE SPC A LV A S QY GWS GN ME R IM KA QA Y qtg K D I S TNY Y ASQ KKT F E I NPRHP L I RDML RR IKE DE D DK 708
Cdd:PTZ00272 553 DK V EK VI VS E RL ST SPC I LV T S EF GWS AH ME Q IM RN QA L --- R D S S MAQ Y MMS KKT M E L NPRHP I I KELR RR VGA DE N DK 629
650 660 670 680
....*....|....*....|....*....|....*....|....*.
gi 119360 709 T V L DL AVV LF E T AT L R SG YL L P D TKA Y GD RI E RM LR L S L NI D PDAK 754
Cdd:PTZ00272 630 A V K DL VFL LF D T SL L T SG FQ L E D PTG Y AE RI N RM IK L G L SL D EEEE 675
PTZ00130
PTZ00130 heat shock protein 90; Provisional
9-755
0e+00
heat shock protein 90; Provisional
Pssm-ID: 185466 [Multi-domain]
Cd Length: 814
Bit Score: 539.24
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 9 L C CVLLTFGSVRADDEVDV D GTVE E DLGKSR E GSRTD D EVVQR E EEAIQLD G LNAS Q irelreksekfa F Q A EV N R M M KL 88
Cdd:PTZ00130 13 I C ALQPNWVPQLCNVLCES D EGKS E EKEEKE E VKKDR D NIPEI E DGEKPTS G IEQH Q ------------ Y Q T EV T R L M DI 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 89 I I NSLY KN KE I FLRELISNA S DAL D KIR LI SL T DE NA L SGNEE L TVK I KCD KEKN L L HV TDTG V GMT R E E L VK NLGTIAK 168
Cdd:PTZ00130 81 I V NSLY TQ KE V FLRELISNA A DAL E KIR FL SL S DE SV L GEEKK L EIR I SAN KEKN I L SI TDTG I GMT K E D L IN NLGTIAK 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 169 SGTS E FL NKMTEAQE D gqst SE LIGQFGVGFYSAFLVADKVIV TS K H NND T Q H IWES DSN - E F SVIA DPRG N TL G RGT T I 247
Cdd:PTZ00130 161 SGTS N FL EAISKSGG D ---- MS LIGQFGVGFYSAFLVADKVIV YT K N NND E Q Y IWES TAD a K F TIYK DPRG S TL K RGT R I 236
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 248 T L V LKE E A SDYLELDTIKN L VK KYSQFI NF PIY VWSSK tet V EEPMEEEEA AKE EKEESDDEAAVE EE EEEKKP KT KK VE 327
Cdd:PTZ00130 237 S L H LKE D A TNLMNDKKLVD L IS KYSQFI QY PIY LLHEN --- V YTEEVLADI AKE MENDPNYDSVKV EE TDDPNK KT RT VE 313
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 328 K T V WD W E LMN DI KPIW Q RP S KE VEEDE YK A F YKSF S KES D D P MAY IHF T AEGE VT FK SILFV P TS AP R gl FDEYGSK K SD 407
Cdd:PTZ00130 314 K K V KK W K LMN EQ KPIW L RP P KE LTDED YK K F FSVL S GFN D E P LYH IHF F AEGE IE FK CLIYI P SR AP S -- INDHLFT K QN 391
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 408 Y IKLYVRRV FIT D D F HDMM P K Y LN FVKGVVDSDDLPLNVSRE T LQQ H K L LK VIR K KL VRK T LD ----------------- 470
Cdd:PTZ00130 392 S IKLYVRRV LVA D E F VEFL P R Y MS FVKGVVDSDDLPLNVSRE Q LQQ N K I LK AVS K RI VRK I LD tfrtlykegkknketlr 471
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 471 -------------- MI KKI ADDKYNDTFW KE FGTNI K L G VI ED HS NR TRLA KLL R F QSSH HP TD I t SLD Q Y V E R MK EK Q D 536
Cdd:PTZ00130 472 aelaketdeekkke IQ KKI NEPSTYKLIY KE YRKYL K T G CY ED DI NR NKIV KLL L F KTML HP KS I - SLD T Y I E N MK PD Q K 550
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 537 K IY FMA G S S RKEAESS P FVERLL KK GYE V IY LTE P VDE Y C I Q ALP E F DGK R F QNVA K EGVK F DES E KT K ESR E A V E K EFE 616
Cdd:PTZ00130 551 F IY YAS G D S YEYLSKI P QLQIFK KK NID V VF LTE S VDE S C V Q RVQ E Y DGK K F KSIQ K GEIT F ELT E DE K KKE E K V K K MYK 630
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 617 P L LNWMK D k A L KDK I E K AVV S Q RL TES PCA L V ASQY G W SG N ME RI MK AQAYQTGKDIST nyya S QK K TF EINP R HP LIR D 696
Cdd:PTZ00130 631 A L IDVIS D - T L RNQ I F K VEI S R RL VDA PCA V V STEW G L SG Q ME KL MK INVNNSDQIKAM ---- S GQ K IL EINP D HP IMI D 705
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|....*....
gi 119360 697 M L R R IKEDED D KTVLDLAVVLFET A T L R SG YL L P DT KAYGDRIERMLRLS L NI D PDA K V 755
Cdd:PTZ00130 706 L L K R SVSNPK D SQLTESIKIIYQS A K L A SG FD L E DT ADLAQIVYDHINQK L GV D NNL K I 764
HATPase_Hsp90-like
cd16927 Histidine kinase-like ATPase domain of human cytosolic Hsp90 and its homologs including ...
83-275
9.03e-99
Histidine kinase-like ATPase domain of human cytosolic Hsp90 and its homologs including Escherichia coli HtpG, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of 90 kilodalton heat-shock protein (Hsp90) eukaryotic homologs including cytosolic Hsp90, mitochondrial TRAP1 (tumor necrosis factor receptor-associated protein 1), GRP94 (94 kDa glucose-regulated protein) of the endoplasmic reticulum (ER), and chloroplast Hsp90C. It also includes the bacterial homologs of Hsp90, known as HtpG (High temperature protein G). Hsp90 family of chaperones assist other proteins to fold correctly, stabilizes them against heat stress, and aids in protein degradation.
Pssm-ID: 340404 [Multi-domain]
Cd Length: 189
Bit Score: 304.06
E-value: 9.03e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 83 N RMMK LII N SLY K NKEIFLRELISNASDALDK I R LI SLTD ENA L SGNE EL TVK I KC DKE KNL L HVT DTG V GMT R EEL VK N 162
Cdd:cd16927 1 N QLLD LII H SLY S NKEIFLRELISNASDALDK L R YL SLTD PSL L DDDP EL EIR I SP DKE NRT L TIS DTG I GMT K EEL IN N 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 163 LGTIA K SGT SE FL NKMT E AQE D gqst S E LIGQFGVGFYSAF L VADKV I VT S K HN - N D TQHI WESD SNEFSV I ADPR G N t L 241
Cdd:cd16927 81 LGTIA R SGT KA FL EALQ E GAK D ---- S D LIGQFGVGFYSAF M VADKV T VT T K SA g D D EGYR WESD GGGSYT I EEAE G E - L 155
170 180 190
....*....|....*....|....*....|....
gi 119360 242 GRGT T ITL V LKE E A SDY LE LDT IK N LVKKYS Q FI 275
Cdd:cd16927 156 GRGT K ITL H LKE D A KEF LE EAR IK E LVKKYS D FI 189
PRK14083
PRK14083 HSP90 family protein; Provisional
77-464
1.09e-27
HSP90 family protein; Provisional
Pssm-ID: 237603 [Multi-domain]
Cd Length: 601
Bit Score: 118.89
E-value: 1.09e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 77 A FQ AEVNRMMK L IINS LY KNKEIFL REL IS NA S DA ldk I RLISLT D EN A lsg NEELTVKIKCDKEKN L L h V T D T G V G M T R 156
Cdd:PRK14083 4 R FQ VDLRGVID L LSRH LY SSPRVYV REL LQ NA V DA --- I TARRAL D PT A --- PGRIRIELTDAGGGT L I - V E D N G I G L T E 76
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 157 EE LVKN L G TI AK S GTSE flnkmtea QED G QSTSELI GQFG V G FY S A FLVAD KVI V T S KHNN D TQHI - W -- ES D SN e F SV I 233
Cdd:PRK14083 77 EE VHEF L A TI GR S SKRD -------- ENL G FARNDFL GQFG I G LL S C FLVAD EIV V V S RSAK D GPAV e W rg KA D GT - Y SV R 147
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 234 ADP r GNTLGR GTT IT L VLKEE A SDY LE LD T IKN L V KKY SQFINF PI Y V wssktetveepmeeeeaakeekeesddeaave 313
Cdd:PRK14083 148 KLE - TERAEP GTT VY L RPRPD A EEW LE RE T VEE L A KKY GSLLPV PI R V -------------------------------- 194
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 314 eeeeekkpktkkvekt VWDWELM N DIK P I W Q R -- P SK E VEEDEYK A FYKS - FSKE sdd P MAY I HFTAEGEVTF k SILF V - 389
Cdd:PRK14083 195 ---------------- EGEKGGV N ETP P P W T R dy P DP E TRREALL A YGEE l LGFT --- P LDV I PLDVPSGGLE - GVAY V l 254
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 119360 390 P TSAP rglfde YGSKKSD yi KL Y VR R VFITDDFHDMM P KYLN FV KG VV DS D D L PLNV SRE T L QQHKL L KVI R KK L 464
Cdd:PRK14083 255 P YAVS ------ PAARRKH -- RV Y LK R MLLSEEAENLL P DWAF FV RC VV NT D E L RPTA SRE A L YEDDA L AAV R EE L 321
HATPase_c
smart00387 Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
96-254
5.09e-09
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain]
Cd Length: 111
Bit Score: 54.58
E-value: 5.09e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 96 NKEIF LR ELI SN AS D aldkirlisltde NA L --- SGNEEL TV KIKC D KEKNLLH V T D T G V G MTR E E lvknlgtiaksgts 172
Cdd:smart00387 1 GDPDR LR QVL SN LL D ------------- NA I kyt PEGGRI TV TLER D GDHVEIT V E D N G P G IPP E D -------------- 53
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 173 ef L N K MT E AQEDGQST S EL IG QF G V G FYSAFLVADKVIVTSKHN ndtqhiwesdsnefsviadprg NTL G R GTT I T LV L K 252
Cdd:smart00387 54 -- L E K IF E PFFRTDKR S RK IG GT G L G LSIVKKLVELHGGEISVE ---------------------- SEP G G GTT F T IT L P 109
..
gi 119360 253 E E 254
Cdd:smart00387 110 L E 111
HATPase_c_3
pfam13589 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, ...
124-222
8.41e-06
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 433332 [Multi-domain]
Cd Length: 135
Bit Score: 46.17
E-value: 8.41e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 124 N ALSGNEE l TV KI KCD K EKNL --- LHVT D T G V GM TR EEL VKN L G t I A K S gtsefl N K MTEAQEDG qstsel I G QF G V G FY 200
Cdd:pfam13589 11 N SIDADAT - NI KI EVN K NRGG gte IVIE D D G H GM SP EEL INA L R - L A T S ------ A K EAKRGSTD ------ L G RY G I G LK 76
90 100
....*....|....*....|...
gi 119360 201 S A F L V - AD K VI VTSK HNNDTQHI 222
Cdd:pfam13589 77 L A S L S l GA K LT VTSK KEGKSSTL 99
HATPase_c
pfam02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
96-254
4.38e-05
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain]
Cd Length: 109
Bit Score: 43.13
E-value: 4.38e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 96 NK E IF LR ELI SN AS D ALD K irlisltden ALSGNE E L TV KIKCD k EKNL L H V T D T G V G MTR E E L v KNLG tiaksgtsefl 175
Cdd:pfam02518 1 GD E LR LR QVL SN LL D NAL K ---------- HAAKAG E I TV TLSEG - GELT L T V E D N G I G IPP E D L - PRIF ----------- 57
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 119360 176 nkmteaqe DGQ ST SELI G QF G V G F ys AFLVAD K VI vt SKHNND tqh I W esdsnefsviadp RGNTL G R GTT I TL V L KEE 254
Cdd:pfam02518 58 -------- EPF ST ADKR G GG G T G L -- GLSIVR K LV -- ELLGGT --- I T ------------- VESEP G G GTT V TL T L PLA 108
HATPase_MORC-like
cd16931 Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger ...
101-217
5.37e-04
Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains. In addition to the HATPase domain, MORC family proteins have a CW-type zinc finger domain containing four conserved cysteines and two conserved tryptophans, and coiled-coil domains at the carboxy-terminus. MORC1 has cross-species differential methylation in association with early life stress, and genome-wide association with major depressive disorder (MDD). MORC2 is involved in several nuclear processes, including transcription modulation and DNA damage repair, and exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY. MORC3 regulates p53, and is an antiviral factor which plays an important role during HSV-1 and HCMV infection, and is a positive regulator of influenza virus transcription. MORC4 is highly expressed in a subset of diffuse large B-cell lymphomas and has potential as a lymphoma biomarker.
Pssm-ID: 340408 [Multi-domain]
Cd Length: 118
Bit Score: 40.47
E-value: 5.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360 101 LR EL IS NA S DA ldkirlislt D ENA L sgn EELTVK I KCDKEKNL L HVT D T G V GMT R EE LVKNLGT iaks G T S eflnkmte 180
Cdd:cd16931 16 VA EL VD NA R DA ---------- D ATR L --- DIFIDD I NLLRGGFM L SFL D D G N GMT P EE AHHMISF ---- G F S -------- 70
90 100 110
....*....|....*....|....*....|....*...
gi 119360 181 aq EDGQSTSEL IG QF G V GF Y S - AFLVADK VIV TS K HNN 217
Cdd:cd16931 71 -- DKRSDDHDH IG RY G N GF K S g SMRLGRD VIV FT K KDE 106
KinB
COG5806 Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ...
125-165
1.92e-03
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain]
Cd Length: 412
Bit Score: 41.39
E-value: 1.92e-03
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 119360 125 A LSGNEE LT VKIKC DK E K NLLHVT DTGVGMT R E E L v KN LG T 165
Cdd:COG5806 326 A MPNGGT LT IDVSI DK N K VIISIK DTGVGMT K E Q L - ER LG E 365
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
