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Conserved domains on  [gi|116038|sp|P10300|]
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RecName: Full=T-cell surface glycoprotein CD8 beta chain; AltName: Full=Lymphocyte antigen 3; AltName: Full=T-cell membrane glycoprotein Ly-3; AltName: Full=T-cell surface glycoprotein Lyt-3; AltName: CD_antigen=CD8b; Flags: Precursor

Protein Classification

IgV_CD8_beta domain-containing protein( domain architecture ID 10166777)

IgV_CD8_beta domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IgV_CD8_beta cd07700
Immunoglobulin (Ig) variable (V) domain of Cluster of Differentiation (CD) 8 beta chain; The ...
 22-136 2.48e-68

Immunoglobulin (Ig) variable (V) domain of Cluster of Differentiation (CD) 8 beta chain; The members here are composed of the immunoglobulin (Ig)-like domain in Cluster of Differentiation (CD) 8 beta. The CD8 glycoprotein plays an essential role in the control of T-cell selection, maturation, and the T-cell receptor (TCR)-mediated response to peptide antigen. CD8 is comprised of alpha and beta subunits and is expressed as either an alpha/alpha or alpha/beta dimer. Both dimeric isoforms can serve as a coreceptor for T cell activation and differentiation, however they have distinct physiological roles, different cellular distributions, unique binding partners, etc. Each CD8 subunit is comprised of an extracellular domain containing a V-type Ig-like domain, a single pass transmembrane portion, and a short intracellular domain. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


:

Pssm-ID: 409497  Cd Length: 116  Bit Score: 204.99  E-value: 2.48e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116038    22 LIQTPSSLLVQTNHTAKMSCEVKSISKLTSIYWLRERQDP-KDKYFEFLASWSSSKGVLYGESVDKKRNIILESSDSRRP 100
Cdd:cd07700   1 LLQTPGSLLVQTNQTVKMSCEAKTSPKNTRIYWLRQRQAPsKDSHFEFLASWDPSKGIVYGEGVDQEKLIILSDSDSSRY 80

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 116038   101 FLSIMNVKPEDSDFYFCATVGSPKMVFGTGTKLTVV 136
Cdd:cd07700  81 ILSLMSVKPEDSGTYFCMTVGSPELIFGTGTKLSVV 116
 
Name Accession Description Interval E-value
IgV_CD8_beta cd07700
Immunoglobulin (Ig) variable (V) domain of Cluster of Differentiation (CD) 8 beta chain; The ...
 22-136 2.48e-68

Immunoglobulin (Ig) variable (V) domain of Cluster of Differentiation (CD) 8 beta chain; The members here are composed of the immunoglobulin (Ig)-like domain in Cluster of Differentiation (CD) 8 beta. The CD8 glycoprotein plays an essential role in the control of T-cell selection, maturation, and the T-cell receptor (TCR)-mediated response to peptide antigen. CD8 is comprised of alpha and beta subunits and is expressed as either an alpha/alpha or alpha/beta dimer. Both dimeric isoforms can serve as a coreceptor for T cell activation and differentiation, however they have distinct physiological roles, different cellular distributions, unique binding partners, etc. Each CD8 subunit is comprised of an extracellular domain containing a V-type Ig-like domain, a single pass transmembrane portion, and a short intracellular domain. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409497  Cd Length: 116  Bit Score: 204.99  E-value: 2.48e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116038    22 LIQTPSSLLVQTNHTAKMSCEVKSISKLTSIYWLRERQDP-KDKYFEFLASWSSSKGVLYGESVDKKRNIILESSDSRRP 100
Cdd:cd07700   1 LLQTPGSLLVQTNQTVKMSCEAKTSPKNTRIYWLRQRQAPsKDSHFEFLASWDPSKGIVYGEGVDQEKLIILSDSDSSRY 80

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 116038   101 FLSIMNVKPEDSDFYFCATVGSPKMVFGTGTKLTVV 136
Cdd:cd07700  81 ILSLMSVKPEDSGTYFCMTVGSPELIFGTGTKLSVV 116
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 24-136 1.01e-19

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 80.58  E-value: 1.01e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116038      24 QTPSSLLVQTNHTAKMSCEVKS--ISKLTSIYWLRERQDPKDKYFEFLASwssskgVLYGESVDKKRNIILESSDSRRPF 101
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYSSsmSEASTSVYWYRQPPGKGPTFLIAYYS------NGSEEGVKKGRFSGRGDPSNGDGS 74

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 116038     102 LSIMNVKPEDSDFYFCATVGSPKMVFGTGTKLTVV 136
Cdd:pfam07686  75 LTIQNLTLSDSGTYTCAVIPSGEGVFGKGTRLTVL 109
IGv smart00406
Immunoglobulin V-Type;
36-119 1.58e-11

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 58.16  E-value: 1.58e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116038       36 TAKMSCEVKSISK-LTSIYWLRERQDpkdKYFEFLASWSSSKGVLYGESVdKKRNIILESSDSRRPFLSIMNVKPEDSDF 114
Cdd:smart00406   1 SVTLSCKFSGSTFsSYYVSWVRQPPG---KGLEWLGYIGSNGSSYYQESY-KGRFTISKDTSKNDVSLTISNLRVEDTGT 76


                   ....*
gi 116038      115 YFCAT 119
Cdd:smart00406  77 YYCAV 81
 
Name Accession Description Interval E-value
IgV_CD8_beta cd07700
Immunoglobulin (Ig) variable (V) domain of Cluster of Differentiation (CD) 8 beta chain; The ...
 22-136 2.48e-68

Immunoglobulin (Ig) variable (V) domain of Cluster of Differentiation (CD) 8 beta chain; The members here are composed of the immunoglobulin (Ig)-like domain in Cluster of Differentiation (CD) 8 beta. The CD8 glycoprotein plays an essential role in the control of T-cell selection, maturation, and the T-cell receptor (TCR)-mediated response to peptide antigen. CD8 is comprised of alpha and beta subunits and is expressed as either an alpha/alpha or alpha/beta dimer. Both dimeric isoforms can serve as a coreceptor for T cell activation and differentiation, however they have distinct physiological roles, different cellular distributions, unique binding partners, etc. Each CD8 subunit is comprised of an extracellular domain containing a V-type Ig-like domain, a single pass transmembrane portion, and a short intracellular domain. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409497  Cd Length: 116  Bit Score: 204.99  E-value: 2.48e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116038    22 LIQTPSSLLVQTNHTAKMSCEVKSISKLTSIYWLRERQDP-KDKYFEFLASWSSSKGVLYGESVDKKRNIILESSDSRRP 100
Cdd:cd07700   1 LLQTPGSLLVQTNQTVKMSCEAKTSPKNTRIYWLRQRQAPsKDSHFEFLASWDPSKGIVYGEGVDQEKLIILSDSDSSRY 80

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 116038   101 FLSIMNVKPEDSDFYFCATVGSPKMVFGTGTKLTVV 136
Cdd:cd07700  81 ILSLMSVKPEDSGTYFCMTVGSPELIFGTGTKLSVV 116
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 22-135 5.37e-30

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 107.03  E-value: 5.37e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116038    22 LIQTPSSLLVQTNHTAKMSCEVKSISKLTSIYWLreRQDPkDKYFEFLASWSSSKGVlygESVDKKRNIILESSDSRRPF 101
Cdd:cd00099   1 VTQSPRSLSVQEGESVTLSCEVSSSFSSTYIYWY--RQKP-GQGPEFLIYLSSSKGK---TKGGVPGRFSGSRDGTSSFS 74

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 116038   102 LSIMNVKPEDSDFYFCATVGSP---KMVFGTGTKLTV 135
Cdd:cd00099  75 LTISNLQPEDSGTYYCAVSESGgtdKLTFGSGTRLTV 111
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 24-136 1.01e-19

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 80.58  E-value: 1.01e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116038      24 QTPSSLLVQTNHTAKMSCEVKS--ISKLTSIYWLRERQDPKDKYFEFLASwssskgVLYGESVDKKRNIILESSDSRRPF 101
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYSSsmSEASTSVYWYRQPPGKGPTFLIAYYS------NGSEEGVKKGRFSGRGDPSNGDGS 74

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 116038     102 LSIMNVKPEDSDFYFCATVGSPKMVFGTGTKLTVV 136
Cdd:pfam07686  75 LTIQNLTLSDSGTYTCAVIPSGEGVFGKGTRLTVL 109
IgV_TCR_alpha cd04983
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar ...
 23-135 7.24e-12

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar proteins; The members here are composed of the immunoglobulin (Ig) variable domain of the alpha chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta polypeptide chains with variable (V) and constant (C) regions. This group represents the variable domain of the alpha chain of TCRs and also includes the variable domain of delta chains of TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409372 [Multi-domain]  Cd Length: 109  Bit Score: 59.59  E-value: 7.24e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116038    23 IQTPSSLLVQTNHTAKMSCEVKSISkLTSIYWLRerQDPkDKYFEFLASWSSSKGVlygesvDKKRNIILESSDSRRPF- 101
Cdd:cd04983   2 TQSPQSLSVQEGENVTLNCNYSTST-FYYLFWYR--QYP-GQGPQFLIYISSDSGN------KKKGRFSATLDKSRKSSs 71

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 116038   102 LSIMNVKPEDSDFYFCATVGSP---KMVFGTGTKLTV 135
Cdd:cd04983  72 LHISAAQLSDSAVYFCALSESGgtgKLTFGKGTRLTV 108
IgV_TCR_beta cd05899
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain; The members here ...
 22-135 1.00e-11

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain; The members here are composed of the immunoglobulin (Ig) variable domain of the beta chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta, polypeptide chains with variable (V) and constant (C) regions. This group includes the variable domain of the alpha chain of alpha/beta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409480  Cd Length: 110  Bit Score: 59.60  E-value: 1.00e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116038    22 LIQTPSSLLVQTNHTAKMSCEvkSISKLTSIYWLRerQDPKdKYFEFLAsWSSSKGVLYGESVDKKRNIILESSDSRRPf 101
Cdd:cd05899   1 VTQSPRYLIKRRGQSVTLRCS--QKSGHDNMYWYR--QDPG-KGLQLLF-YSYGGGLNEEGDLPGDRFSASRPSLTRSS- 73

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 116038   102 LSIMNVKPEDSDFYFCA---TVGSPKMVFGTGTKLTV 135
Cdd:cd05899  74 LTIKSAEPEDSAVYLCAsslGGGADEAYFGPGTRLTV 110
IGv smart00406
Immunoglobulin V-Type;
36-119 1.58e-11

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 58.16  E-value: 1.58e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116038       36 TAKMSCEVKSISK-LTSIYWLRERQDpkdKYFEFLASWSSSKGVLYGESVdKKRNIILESSDSRRPFLSIMNVKPEDSDF 114
Cdd:smart00406   1 SVTLSCKFSGSTFsSYYVSWVRQPPG---KGLEWLGYIGSNGSSYYQESY-KGRFTISKDTSKNDVSLTISNLRVEDTGT 76


                   ....*
gi 116038      115 YFCAT 119
Cdd:smart00406  77 YYCAV 81
IgV_TCR_gamma cd04982
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here ...
 22-135 1.45e-10

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the gamma chain of gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigens as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain the standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409371  Cd Length: 117  Bit Score: 56.60  E-value: 1.45e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116038    22 LIQTPSSLLVQTNHTAKMSCEVKSIS-KLTSIYWLRERqdpKDKYFEFLASWSSSKGVLYGESVDKKRNIILESSDSRRP 100
Cdd:cd04982   1 LEQPQLSITREESKSVTISCKVSGIDfSTTYIHWYRQK---PGQALERLLYVSSTSAVRKDSGKTKNKFEARKDVGKSTS 77

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 116038   101 FLSIMNVKPEDSDFYFCAT----VGSPKMVFGTGTKLTV 135
Cdd:cd04982  78 TLTITNLEKEDSATYYCAYwesgSGYYIKVFGSGTKLIV 116
IgV_L_lambda cd04984
Immunoglobulin (Ig) lambda light chain variable (V) domain; The members here are composed of ...
 22-135 8.37e-10

Immunoglobulin (Ig) lambda light chain variable (V) domain; The members here are composed of the immunoglobulin (Ig) light chain, lambda type, variable (V) domain. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which seem to be functionally identical, and can associate with any of the heavy chains. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409373  Cd Length: 105  Bit Score: 54.00  E-value: 8.37e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116038    22 LIQtPSSLLVQTNHTAKMSCEVKSISKLTS-IYWLRERQDpkdkyfeflaswSSSKGVLYGesvDKKR-NIILE----SS 95
Cdd:cd04984   2 LTQ-PSSLSVSPGETVTITCTGSSGNISGNyVNWYQQKPG------------SAPRYLIYE---DKHRpSGIPDrfsgSK 65

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 116038    96 DSRRPFLSIMNVKPEDSDFYFCATVGSPKMVFGTGTKLTV 135
Cdd:cd04984  66 SGNTASLTISGAQTEDEADYYCQVWDSNSYVFGGGTKLTV 105
IgV_L_kappa cd04980
Immunoglobulin (Ig) light chain, kappa type, variable (V) domain; The members here are ...
 22-135 2.09e-08

Immunoglobulin (Ig) light chain, kappa type, variable (V) domain; The members here are composed of the immunoglobulin (Ig) light chain, kappa type, variable (V) domain. This group contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which seem to be functionally identical, and can associate with any of the heavy chains.


Pssm-ID: 409369  Cd Length: 106  Bit Score: 50.47  E-value: 2.09e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116038    22 LIQTPSSLLVQTNHTAKMSCEVKSISKLTSIYWLRER--QDPKdkyfeFLASWSSSKgvlygESVDKKRniiLESSDSRR 99
Cdd:cd04980   3 MTQSPASLSVSPGERVTISCKASQSISSNYLAWYQQKpgQAPK-----LLIYYASTL-----HSGVPSR---FSGSGSGT 69

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 116038   100 PF-LSIMNVKPEDSDFYFCATVGSPKMVFGTGTKLTV 135
Cdd:cd04980  70 DFtLTISSVEPEDAAVYYCQQGYTFPYTFGGGTKLEI 106
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 26-135 1.34e-07

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 47.50  E-value: 1.34e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116038       26 PSSLLVQTNHTAKMSCEVKSISKLTsIYWLRERQDPkdkyfeflaswssskgvlygesVDKKRNIILeSSDSRRPFLSIM 105
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSPPPE-VTWYKQGGKL----------------------LAESGRFSV-SRSGSTSTLTIS 56

                           90       100       110
                   ....*....|....*....|....*....|
gi 116038      106 NVKPEDSDFYFCATVGSPKMVFGtGTKLTV 135
Cdd:smart00410  57 NVTPEDSGTYTCAATNSSGSASS-GTTLTV 85
IgV_H cd04981
Immunoglobulin (Ig) heavy chain (H), variable (V) domain; The members here are composed of the ...
 24-135 3.85e-05

Immunoglobulin (Ig) heavy chain (H), variable (V) domain; The members here are composed of the immunoglobulin (Ig) heavy chain (H), variable (V) domain. This group contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which can associate with any of the heavy chains. This family includes alpha, gamma, delta, epsilon, and mu heavy chains.


Pssm-ID: 409370 [Multi-domain]  Cd Length: 118  Bit Score: 41.53  E-value: 3.85e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116038    24 QTPSSLLVQTNHTAKMSCEVkSISKLTS--IYWLRERQDpkdKYFEFLASWSSSKGVL-YGESVDKKRNIILESSDSRrP 100
Cdd:cd04981   3 QESGPGLVKPGQSLKLSCKA-SGFTFTSygMGWVRQAPG---KGLEWIGLIYPGGGDTyYADSFKGRFTITRDTSKST-A 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 116038   101 FLSIMNVKPEDSDFYFCATVGSPKM-----VFGTGTKLTV 135
Cdd:cd04981  78 YLQLNSLTSEDTAVYYCARGLGGYGysyfdYWGQGTTVTV 117
IgV_TCR_delta cd07706
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) delta chain; The members here ...
 102-135 1.01e-03

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) delta chain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the delta chain of gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens; they recognize protein antigens directly and without antigen processing, and MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409503  Cd Length: 112  Bit Score: 37.50  E-value: 1.01e-03
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 116038   102 LSIMNVKPEDSDFYFCATVGSP---KMVFGTGTKLTV 135
Cdd:cd07706  74 LTISALQLEDSAKYFCALSLPYdtdKLIFGKGTRLTV 110
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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