NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|122069112|sp|P10076|]
View 

RecName: Full=Zinc finger protein 26; Short=Zfp-26; AltName: Full=Protein mKR3

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204268)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

CATH:  3.30.160.60
Gene Ontology:  GO:0003700|GO:0046872
PubMed:  22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
9-67 6.54e-28

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 106.91  E-value: 6.54e-28
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 122069112     9 VTFEDVAVDFTQEEWTSLDPVQRNLYRDVMLENYQNLATVGGQMFKPSLISWLEKKVEL 67
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEP 59
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
221-656 7.85e-18

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 87.44  E-value: 7.85e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122069112 221 SEECGQASTHPISHGGHVIPTEKKYYECKKCEKFFTHPVYLNIHMQSHTVEKPYDC--KECGKAFTERSSLIVHLRQHTR 298
Cdd:COG5048    9 SSSNNSVLSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHN 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122069112 299 EKSYEC-KECGKTFIQPSRLTEHMRSHTGEKPYQCDQCGNAFASSSYLT--THLRTHTGEKPFECNIcGKAFTRSSYLLG 375
Cdd:COG5048   89 NPSDLNsKSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLpdLLSISNLRNNPLPGNN-SSSVNTPQSNSL 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122069112 376 HIRTHTGEKpyeckvCGKAFSGRSWLTIHLRKHTGERPYPCTECEKAFTSFAQLTEHIKTH-TGEKPFRCKVCARTFRNS 454
Cdd:COG5048  168 HPPLPANSL------SKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENsSSSLPLTTNSQLSPKSLL 241
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122069112 455 SCLKTH----FRIHTGIKPYKCNYCGKAFTARSGLTKHVLIHNG-EKPYECKECGKAFSTSSGLVEHIR--IHTGE--KP 525
Cdd:COG5048  242 SQSPSSlsssDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKP 321
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122069112 526 FEC--YQCGKALAHSSSLVGHLRTHTGEKPFEC--NQCDKTFTRSSY-----LRIHMRTHTGEKPYEC--KECGKTFPER 594
Cdd:COG5048  322 FSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRD 401
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 122069112 595 SCLTKHIRTHTGERPYECK--ECGKGFISFAQLTVHIKTHSSERPFQCKvCTKSFRNSSSLETH 656
Cdd:COG5048  402 SNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCS-ILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
496-852 9.18e-12

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 68.18  E-value: 9.18e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122069112 496 KPYECKECGKAFSTSSGLVEHIRIHTGEKPFECYQCGKALAHSSSLVG--HLRTHTGEKPFECNQ--CDKTFTRSSYLrI 571
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELsrHLRTHHNNPSDLNSKslPLSNSKASSSS-L 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122069112 572 HMRTHTGEKPYECKECGKTFPERSCLTKHIRTHTGERPYECKECGKGFISFAQltvhikthSSERPFQCKVCTKSFRNSS 651
Cdd:COG5048  111 SSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQ--------SNSLHPPLPANSLSKDPSS 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122069112 652 --SLETHFRIHTGVKPYKCSYCGKAFTARSGLTIHLRNHTGEKSYACQECGKAFSTS------SGLIAHIRSHKGEKPFE 723
Cdd:COG5048  183 nlSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSllsqspSSLSSSDSSSSASESPR 262
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122069112 724 CDHCGKAFASSSYLNVHLKIHTG-EKPFQCTVCGKTFTCSSYLPVHMRT--HTGE--KPFQC--IICGKSFLWSSYLRVH 796
Cdd:COG5048  263 SSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRH 342
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 122069112 797 MRIHTGEKPYVCQYCGKAFTEHSGLNK----HLRKHTGEKPYEYKECGENFTTSADANEH 852
Cdd:COG5048  343 ILLHTSISPAKEKLLNSSSKFSPLLNNeppqSLQQYKDLKNDKKSETLSNSCIRNFKRDS 402
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
9-67 6.54e-28

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 106.91  E-value: 6.54e-28
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 122069112     9 VTFEDVAVDFTQEEWTSLDPVQRNLYRDVMLENYQNLATVGGQMFKPSLISWLEKKVEL 67
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEP 59
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
9-49 2.68e-24

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 96.00  E-value: 2.68e-24
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 122069112    9 VTFEDVAVDFTQEEWTSLDPVQRNLYRDVMLENYQNLATVG 49
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
9-46 3.84e-20

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 84.14  E-value: 3.84e-20
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 122069112   9 VTFEDVAVDFTQEEWTSLDPVQRNLYRDVMLENYQNLA 46
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
221-656 7.85e-18

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 87.44  E-value: 7.85e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122069112 221 SEECGQASTHPISHGGHVIPTEKKYYECKKCEKFFTHPVYLNIHMQSHTVEKPYDC--KECGKAFTERSSLIVHLRQHTR 298
Cdd:COG5048    9 SSSNNSVLSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHN 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122069112 299 EKSYEC-KECGKTFIQPSRLTEHMRSHTGEKPYQCDQCGNAFASSSYLT--THLRTHTGEKPFECNIcGKAFTRSSYLLG 375
Cdd:COG5048   89 NPSDLNsKSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLpdLLSISNLRNNPLPGNN-SSSVNTPQSNSL 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122069112 376 HIRTHTGEKpyeckvCGKAFSGRSWLTIHLRKHTGERPYPCTECEKAFTSFAQLTEHIKTH-TGEKPFRCKVCARTFRNS 454
Cdd:COG5048  168 HPPLPANSL------SKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENsSSSLPLTTNSQLSPKSLL 241
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122069112 455 SCLKTH----FRIHTGIKPYKCNYCGKAFTARSGLTKHVLIHNG-EKPYECKECGKAFSTSSGLVEHIR--IHTGE--KP 525
Cdd:COG5048  242 SQSPSSlsssDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKP 321
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122069112 526 FEC--YQCGKALAHSSSLVGHLRTHTGEKPFEC--NQCDKTFTRSSY-----LRIHMRTHTGEKPYEC--KECGKTFPER 594
Cdd:COG5048  322 FSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRD 401
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 122069112 595 SCLTKHIRTHTGERPYECK--ECGKGFISFAQLTVHIKTHSSERPFQCKvCTKSFRNSSSLETH 656
Cdd:COG5048  402 SNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCS-ILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
496-852 9.18e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 68.18  E-value: 9.18e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122069112 496 KPYECKECGKAFSTSSGLVEHIRIHTGEKPFECYQCGKALAHSSSLVG--HLRTHTGEKPFECNQ--CDKTFTRSSYLrI 571
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELsrHLRTHHNNPSDLNSKslPLSNSKASSSS-L 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122069112 572 HMRTHTGEKPYECKECGKTFPERSCLTKHIRTHTGERPYECKECGKGFISFAQltvhikthSSERPFQCKVCTKSFRNSS 651
Cdd:COG5048  111 SSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQ--------SNSLHPPLPANSLSKDPSS 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122069112 652 --SLETHFRIHTGVKPYKCSYCGKAFTARSGLTIHLRNHTGEKSYACQECGKAFSTS------SGLIAHIRSHKGEKPFE 723
Cdd:COG5048  183 nlSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSllsqspSSLSSSDSSSSASESPR 262
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122069112 724 CDHCGKAFASSSYLNVHLKIHTG-EKPFQCTVCGKTFTCSSYLPVHMRT--HTGE--KPFQC--IICGKSFLWSSYLRVH 796
Cdd:COG5048  263 SSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRH 342
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 122069112 797 MRIHTGEKPYVCQYCGKAFTEHSGLNK----HLRKHTGEKPYEYKECGENFTTSADANEH 852
Cdd:COG5048  343 ILLHTSISPAKEKLLNSSSKFSPLLNNeppqSLQQYKDLKNDKKSETLSNSCIRNFKRDS 402
zf-H2C2_2 pfam13465
Zinc-finger double domain;
792-816 6.87e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 6.87e-05
                          10        20
                  ....*....|....*....|....*
gi 122069112  792 YLRVHMRIHTGEKPYVCQYCGKAFT 816
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
568-591 7.43e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 7.43e-05
                          10        20
                  ....*....|....*....|....
gi 122069112  568 YLRIHMRTHTGEKPYECKECGKTF 591
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
664-717 4.08e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 39.85  E-value: 4.08e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 122069112 664 KPYkCSYCGKAFTARSGLTIHLRNHTgeksYACQECGKAFSTSSGLIAHI-RSHK 717
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHClQVHK 50
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
9-67 6.54e-28

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 106.91  E-value: 6.54e-28
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 122069112     9 VTFEDVAVDFTQEEWTSLDPVQRNLYRDVMLENYQNLATVGGQMFKPSLISWLEKKVEL 67
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEP 59
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
9-49 2.68e-24

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 96.00  E-value: 2.68e-24
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 122069112    9 VTFEDVAVDFTQEEWTSLDPVQRNLYRDVMLENYQNLATVG 49
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
9-46 3.84e-20

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 84.14  E-value: 3.84e-20
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 122069112   9 VTFEDVAVDFTQEEWTSLDPVQRNLYRDVMLENYQNLA 46
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
221-656 7.85e-18

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 87.44  E-value: 7.85e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122069112 221 SEECGQASTHPISHGGHVIPTEKKYYECKKCEKFFTHPVYLNIHMQSHTVEKPYDC--KECGKAFTERSSLIVHLRQHTR 298
Cdd:COG5048    9 SSSNNSVLSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHN 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122069112 299 EKSYEC-KECGKTFIQPSRLTEHMRSHTGEKPYQCDQCGNAFASSSYLT--THLRTHTGEKPFECNIcGKAFTRSSYLLG 375
Cdd:COG5048   89 NPSDLNsKSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLpdLLSISNLRNNPLPGNN-SSSVNTPQSNSL 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122069112 376 HIRTHTGEKpyeckvCGKAFSGRSWLTIHLRKHTGERPYPCTECEKAFTSFAQLTEHIKTH-TGEKPFRCKVCARTFRNS 454
Cdd:COG5048  168 HPPLPANSL------SKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENsSSSLPLTTNSQLSPKSLL 241
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122069112 455 SCLKTH----FRIHTGIKPYKCNYCGKAFTARSGLTKHVLIHNG-EKPYECKECGKAFSTSSGLVEHIR--IHTGE--KP 525
Cdd:COG5048  242 SQSPSSlsssDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKP 321
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122069112 526 FEC--YQCGKALAHSSSLVGHLRTHTGEKPFEC--NQCDKTFTRSSY-----LRIHMRTHTGEKPYEC--KECGKTFPER 594
Cdd:COG5048  322 FSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRD 401
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 122069112 595 SCLTKHIRTHTGERPYECK--ECGKGFISFAQLTVHIKTHSSERPFQCKvCTKSFRNSSSLETH 656
Cdd:COG5048  402 SNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCS-ILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
356-787 8.20e-15

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 77.81  E-value: 8.20e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122069112 356 KPFECNICGKAFTRSSYLLGHIRTHTGEKPYECKVCGkafsgrswltihlrkhtgerpypcteCEKAFTSFAQLTEHIKT 435
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSG--------------------------CDKSFSRPLELSRHLRT 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122069112 436 HTGEKPFRC--KVCARTFRNSSCLKTHFrIHTGIKPYKCNYCGKAFTARSGLTKHVL--IHNGEKPYE-CKECGKAFSTS 510
Cdd:COG5048   86 HHNNPSDLNskSLPLSNSKASSSSLSSS-SSNSNDNNLLSSHSLPPSSRDPQLPDLLsiSNLRNNPLPgNNSSSVNTPQS 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122069112 511 SGLveHIRIHTGEKPFECYQCGKALAHSSslvghlrTHTGEKPFECNQCDKTFTRSSYLRIHMRTHTGEKPYECKECGKT 590
Cdd:COG5048  165 NSL--HPPLPANSLSKDPSSNLSLLISSN-------VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQL 235
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122069112 591 FPERSCLTKHIRTHTGERPYECKECGKGFISFA--QLTVHIKTHSSER-----PFQCKVCTKSFRNSSSLETHFR--IHT 661
Cdd:COG5048  236 SPKSLLSQSPSSLSSSDSSSSASESPRSSLPTAssQSSSPNESDSSSEkgfslPIKSKQCNISFSRSSPLTRHLRsvNHS 315
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122069112 662 G--VKPYKC--SYCGKAFTARSGLTIHLRNHTGEKSYAC--QECGKAFSTSS-----GLIAHIRSHKGEKPFECDH--CG 728
Cdd:COG5048  316 GesLKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETLSnsCI 395
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 122069112 729 KAFASSSYLNVHLKIHTGEKP--FQCTVCGKTFTCSSYLPVHMRTHTGEKPFQCIICGKSF 787
Cdd:COG5048  396 RNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFR 456
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
328-740 3.83e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 69.34  E-value: 3.83e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122069112 328 KPYQCDQCGNAFASSSYLTTHLRTHTGEKPFECN--ICGKAFTRSSYLLGHIRTHTGEKPYEC-KVCGKAFSGRSWLTIH 404
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122069112 405 LRKHTGERPYPCTECEKAFTSFAQLTEHIKTHTGEKPFRCKVCARTFRNS-SCLKTHFRIHTGIKpykcnyCGKAFTARS 483
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTpQSNSLHPPLPANSL------SKDPSSNLS 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122069112 484 GLTKHVLIHNGEKPYECKECGKAFSTSSGLVEHIRIH--TGEKPFECYQCGKALAHS---SSLVGHLRTHTGEKPFECNQ 558
Cdd:COG5048  186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENssSSLPLTTNSQLSPKSLLSqspSSLSSSDSSSSASESPRSSL 265
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122069112 559 CDKTFTRSSYLRIHMRTHTG-EKPYECKECGKTFPERSCLTKHIRT--HTGE--RPYECKE--CGKGFISFAQLTVHIKT 631
Cdd:COG5048  266 PTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILL 345
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122069112 632 HSSERPFQCKVCTKSFRNSSSL----ETHFRIHTGVKPYK---CSY--CGKAFTARSGLTIHLRNHTGEKSYACQ--ECG 700
Cdd:COG5048  346 HTSISPAKEKLLNSSSKFSPLLnnepPQSLQQYKDLKNDKkseTLSnsCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCS 425
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|
gi 122069112 701 KAFSTSSGLIAHIRSHKGEKPFECDHCGKAFASSSYLNVH 740
Cdd:COG5048  426 KSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHG 465
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
496-852 9.18e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 68.18  E-value: 9.18e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122069112 496 KPYECKECGKAFSTSSGLVEHIRIHTGEKPFECYQCGKALAHSSSLVG--HLRTHTGEKPFECNQ--CDKTFTRSSYLrI 571
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELsrHLRTHHNNPSDLNSKslPLSNSKASSSS-L 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122069112 572 HMRTHTGEKPYECKECGKTFPERSCLTKHIRTHTGERPYECKECGKGFISFAQltvhikthSSERPFQCKVCTKSFRNSS 651
Cdd:COG5048  111 SSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQ--------SNSLHPPLPANSLSKDPSS 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122069112 652 --SLETHFRIHTGVKPYKCSYCGKAFTARSGLTIHLRNHTGEKSYACQECGKAFSTS------SGLIAHIRSHKGEKPFE 723
Cdd:COG5048  183 nlSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSllsqspSSLSSSDSSSSASESPR 262
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122069112 724 CDHCGKAFASSSYLNVHLKIHTG-EKPFQCTVCGKTFTCSSYLPVHMRT--HTGE--KPFQC--IICGKSFLWSSYLRVH 796
Cdd:COG5048  263 SSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRH 342
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 122069112 797 MRIHTGEKPYVCQYCGKAFTEHSGLNK----HLRKHTGEKPYEYKECGENFTTSADANEH 852
Cdd:COG5048  343 ILLHTSISPAKEKLLNSSSKFSPLLNNeppqSLQQYKDLKNDKKSETLSNSCIRNFKRDS 402
zf-H2C2_2 pfam13465
Zinc-finger double domain;
792-816 6.87e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 6.87e-05
                          10        20
                  ....*....|....*....|....*
gi 122069112  792 YLRVHMRIHTGEKPYVCQYCGKAFT 816
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
568-591 7.43e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 7.43e-05
                          10        20
                  ....*....|....*....|....
gi 122069112  568 YLRIHMRTHTGEKPYECKECGKTF 591
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
438-517 8.35e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.86  E-value: 8.35e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122069112 438 GEKPFRCKV--CARTFRNSSCLKTHfRIHtgikpykcNYCGKAFTARSGLTKHVLIHNGEKPYECKECGKAFSTSSGLVE 515
Cdd:COG5189  346 DGKPYKCPVegCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416

                 ..
gi 122069112 516 HI 517
Cdd:COG5189  417 HR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
316-341 3.20e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 3.20e-04
                          10        20
                  ....*....|....*....|....*.
gi 122069112  316 RLTEHMRSHTGEKPYQCDQCGNAFAS 341
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
664-717 4.08e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 39.85  E-value: 4.08e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 122069112 664 KPYkCSYCGKAFTARSGLTIHLRNHTgeksYACQECGKAFSTSSGLIAHI-RSHK 717
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHClQVHK 50
zf-H2C2_2 pfam13465
Zinc-finger double domain;
344-369 4.74e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 4.74e-04
                          10        20
                  ....*....|....*....|....*.
gi 122069112  344 YLTTHLRTHTGEKPFECNICGKAFTR 369
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
736-761 5.13e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 5.13e-04
                          10        20
                  ....*....|....*....|....*.
gi 122069112  736 YLNVHLKIHTGEKPFQCTVCGKTFTC 761
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
652-676 5.55e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 5.55e-04
                          10        20
                  ....*....|....*....|....*
gi 122069112  652 SLETHFRIHTGVKPYKCSYCGKAFT 676
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
457-480 6.00e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 6.00e-04
                          10        20
                  ....*....|....*....|....
gi 122069112  457 LKTHFRIHTGIKPYKCNYCGKAFT 480
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
382-460 7.39e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.78  E-value: 7.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122069112 382 GEKPYECKV--CGKAFSGRSWLTIH-LRKHTGERPYPcTECEKAFTSFAqltehikthTGEKPFRCKVCARTFRNSSCLK 458
Cdd:COG5189  346 DGKPYKCPVegCNKKYKNQNGLKYHmLHGHQNQKLHE-NPSPEKMNIFS---------AKDKPYRCEVCDKRYKNLNGLK 415

                 ..
gi 122069112 459 TH 460
Cdd:COG5189  416 YH 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
768-787 7.52e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 7.52e-04
                          10        20
                  ....*....|....*....|
gi 122069112  768 HMRTHTGEKPFQCIICGKSF 787
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSF 24
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
726-829 8.64e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.78  E-value: 8.64e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122069112 726 HCGKAFASSSYLNVHLKihtGEKPFQCTV--CGKTFTCSSYLPVHMRT-HTGEKpfqciicgksfLWSSYLRVHMRIHTG 802
Cdd:COG5189  329 HGGERNIDTPSRMLKVK---DGKPYKCPVegCNKKYKNQNGLKYHMLHgHQNQK-----------LHENPSPEKMNIFSA 394
                         90       100
                 ....*....|....*....|....*...
gi 122069112 803 E-KPYVCQYCGKAFTEHSGLNKHlRKHT 829
Cdd:COG5189  395 KdKPYRCEVCDKRYKNLNGLKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
597-621 1.15e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.15e-03
                          10        20
                  ....*....|....*....|....*
gi 122069112  597 LTKHIRTHTGERPYECKECGKGFIS 621
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
544-565 1.18e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.18e-03
                          10        20
                  ....*....|....*....|..
gi 122069112  544 HLRTHTGEKPFECNQCDKTFTR 565
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
554-576 1.21e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.89  E-value: 1.21e-03
                          10        20
                  ....*....|....*....|...
gi 122069112  554 FECNQCDKTFTRSSYLRIHMRTH 576
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
376-396 1.22e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.22e-03
                          10        20
                  ....*....|....*....|.
gi 122069112  376 HIRTHTGEKPYECKVCGKAFS 396
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
401-425 2.72e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.72e-03
                          10        20
                  ....*....|....*....|....*
gi 122069112  401 LTIHLRKHTGERPYPCTECEKAFTS 425
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
260-284 3.69e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.69e-03
                          10        20
                  ....*....|....*....|....*
gi 122069112  260 YLNIHMQSHTVEKPYDCKECGKAFT 284
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
712-733 4.03e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 4.03e-03
                          10        20
                  ....*....|....*....|..
gi 122069112  712 HIRSHKGEKPFECDHCGKAFAS 733
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
485-509 6.04e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 6.04e-03
                          10        20
                  ....*....|....*....|....*
gi 122069112  485 LTKHVLIHNGEKPYECKECGKAFST 509
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
513-534 6.16e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 6.16e-03
                          10        20
                  ....*....|....*....|..
gi 122069112  513 LVEHIRIHTGEKPFECYQCGKA 534
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKS 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
358-380 8.80e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 8.80e-03
                          10        20
                  ....*....|....*....|...
gi 122069112  358 FECNICGKAFTRSSYLLGHIRTH 380
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
582-604 8.89e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 8.89e-03
                          10        20
                  ....*....|....*....|...
gi 122069112  582 YECKECGKTFPERSCLTKHIRTH 604
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
681-705 9.87e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 9.87e-03
                          10        20
                  ....*....|....*....|....*
gi 122069112  681 LTIHLRNHTGEKSYACQECGKAFST 705
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH