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Conserved domains on  [gi|403399437|sp|P0DJM0|]
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RecName: Full=Internalin A; Flags: Precursor

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
internalin_A NF033189
class 1 internalin InlA; Internalins, as found in the intracellular human pathogen Listeria ...
 2-800 0e+00

class 1 internalin InlA; Internalins, as found in the intracellular human pathogen Listeria monocytogenes, are paralogous surface or secreted proteins with an N-terminal signal peptide, leucine-rich repeats, and usually a C-terminal LPXTG processing and cell surface anchoring site. See PMID:17764999 for a general discussion of internalins. Members of this family are internalin A (InlA), a class 1 (LPXTG-type) internalin.


:

Pssm-ID: 380193 [Multi-domain]  Cd Length: 799  Bit Score: 1369.10  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437   2 RKKRYVWLKSILVAILVFGSGVWINTSNGTNAQAATITQDTPINQIFTDTALAEKMKTVLGKTNVTDTVSQTDLDQVTTL 81
Cdd:NF033189   1 RKKRYVWLKSILVAILVFGSGLWINTSNGTNAQAATITQDTPINQIFTDTALAEKMKTVLGKTNVTDTVSQTDLDQVTTL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437  82 QADRLGIKSIDGVEYLNNLTQINFSNNQLTDITPLKNLTKLVDILMNNNQIADITPLANLTNLTGLTLFNNQITDIDPLK 161
Cdd:NF033189  81 QADRLGIKSIDGLEYLNNLTQINFSNNQLTDITPLKDLTKLVDILMNNNQIADITPLANLSNLTGLTLFNNQITDIDPLK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 162 NLTNLNRLELSSNTISDISALSGLTSLQQLSFGNQVTDLKPLANLTTLERLDISSNKVSDISVLAKLTNLESLIATNNQI 241
Cdd:NF033189 161 NLTNLNRLELSSNTISDISALSGLTSLQQLSFGNQVTDLKPLANLTTLERLDISSNKVSDISVLAKLTNLESLIATNNQI 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 242 SDITPLGILTNLDELSLNGNQLKDIGTLASLTNLTDLDLANNQISNLAPLSGLTKLTELKLGANQISNISPLAGLTALTN 321
Cdd:NF033189 241 SDITPLGILTNLDELSLNGNQLKDIGTLASLTNLTDLDLANNQISNLAPLSGLTKLTELKLGANQISNISPLAGLTALTN 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 322 LELNENQLEDISPISNLKNLTYLTLYFNNISDISPVSSLTKLQRLFFYNNKVSDVSSLANLTNINWLSAGHNQISDLTPL 401
Cdd:NF033189 321 LELNENQLEDISPISNLKNLTYLTLYFNNISDISPVSSLTKLQRLFFYNNKVSDVSSLANLTNINWLSAGHNQISDLTPL 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 402 ANLTRITQLGLNDQAWTNAPVNYKANVSIPNTVKNVTGALIAPATISDGGSYTEPDITWNLPSYTNEVSYTFSQPVTIGK 481
Cdd:NF033189 401 ANLTRITQLGLNDQAWTNPPVNYKVNVSIPNTVKNVTGALIAPATISDGGSYAEPDITWNLPSYTNEVSYTFNQSVTIGK 480

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 482 GTTTFSGTVTQPLKAIFNVKFHVDGKETTKEVEAGNLLTEPAKPVKEGHTFVGWFDAQTGGTKWNFSTDKMPTNDINLYA 561
Cdd:NF033189 481 GTTTFSGTVKQPLKAIFNAKFHVDGKETTKEVEAGNLLTEPAKPVKEGHTFIGWFDAQTGGTKWNFSTDKMPTNDIDLYA 560

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 562 QFSINSYTATFDNDGVTTSQTVDYQGLLQEPTAPTKEGYTFKGWYDAKTGGDKWDFATSKMPAKNITLYAQYSANSYTAT 641
Cdd:NF033189 561 QFSINSYTATFDNDGVTTSQTVDYQGLLQEPMAPTKEGYTFKGWYDAKTGGDKWDFATSKMPAKNITLYAQYSANSYTAT 640

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 642 FDVDGKSTTQAVDYQGLLKEPKAPTKAGYTFKGWYDEKTDGKKWDFATDKMPANDITLYAQFTKNPVAPPTTGGNTPPTT 721
Cdd:NF033189 641 FDVDGKTTTQAVDYQGLLKEPKTPTKAGYAFKGWYDEKTDGKKWDFATDKMPANDITLYAQFTKNPVAPPTTGGNTPPTT 720

                        730       740       750       760       770       780       790
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 403399437 722 NNGGNTTPPSANIPGSDTSNTSTGNSASTTSTMNAYDPYNSKEASLPTTGDSDNALYLLLGLLAVGTAMALTKKARASK 800
Cdd:NF033189 721 NNGGNTTPPSANIPGSDTSNTSTGNSASTTSTMNAYDPYNSKDASLPTTGDSDNALYLLIGLLAVGTAVALTKKARANK 799
 
Name Accession Description Interval E-value
internalin_A NF033189
class 1 internalin InlA; Internalins, as found in the intracellular human pathogen Listeria ...
 2-800 0e+00

class 1 internalin InlA; Internalins, as found in the intracellular human pathogen Listeria monocytogenes, are paralogous surface or secreted proteins with an N-terminal signal peptide, leucine-rich repeats, and usually a C-terminal LPXTG processing and cell surface anchoring site. See PMID:17764999 for a general discussion of internalins. Members of this family are internalin A (InlA), a class 1 (LPXTG-type) internalin.


Pssm-ID: 380193 [Multi-domain]  Cd Length: 799  Bit Score: 1369.10  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437   2 RKKRYVWLKSILVAILVFGSGVWINTSNGTNAQAATITQDTPINQIFTDTALAEKMKTVLGKTNVTDTVSQTDLDQVTTL 81
Cdd:NF033189   1 RKKRYVWLKSILVAILVFGSGLWINTSNGTNAQAATITQDTPINQIFTDTALAEKMKTVLGKTNVTDTVSQTDLDQVTTL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437  82 QADRLGIKSIDGVEYLNNLTQINFSNNQLTDITPLKNLTKLVDILMNNNQIADITPLANLTNLTGLTLFNNQITDIDPLK 161
Cdd:NF033189  81 QADRLGIKSIDGLEYLNNLTQINFSNNQLTDITPLKDLTKLVDILMNNNQIADITPLANLSNLTGLTLFNNQITDIDPLK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 162 NLTNLNRLELSSNTISDISALSGLTSLQQLSFGNQVTDLKPLANLTTLERLDISSNKVSDISVLAKLTNLESLIATNNQI 241
Cdd:NF033189 161 NLTNLNRLELSSNTISDISALSGLTSLQQLSFGNQVTDLKPLANLTTLERLDISSNKVSDISVLAKLTNLESLIATNNQI 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 242 SDITPLGILTNLDELSLNGNQLKDIGTLASLTNLTDLDLANNQISNLAPLSGLTKLTELKLGANQISNISPLAGLTALTN 321
Cdd:NF033189 241 SDITPLGILTNLDELSLNGNQLKDIGTLASLTNLTDLDLANNQISNLAPLSGLTKLTELKLGANQISNISPLAGLTALTN 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 322 LELNENQLEDISPISNLKNLTYLTLYFNNISDISPVSSLTKLQRLFFYNNKVSDVSSLANLTNINWLSAGHNQISDLTPL 401
Cdd:NF033189 321 LELNENQLEDISPISNLKNLTYLTLYFNNISDISPVSSLTKLQRLFFYNNKVSDVSSLANLTNINWLSAGHNQISDLTPL 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 402 ANLTRITQLGLNDQAWTNAPVNYKANVSIPNTVKNVTGALIAPATISDGGSYTEPDITWNLPSYTNEVSYTFSQPVTIGK 481
Cdd:NF033189 401 ANLTRITQLGLNDQAWTNPPVNYKVNVSIPNTVKNVTGALIAPATISDGGSYAEPDITWNLPSYTNEVSYTFNQSVTIGK 480

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 482 GTTTFSGTVTQPLKAIFNVKFHVDGKETTKEVEAGNLLTEPAKPVKEGHTFVGWFDAQTGGTKWNFSTDKMPTNDINLYA 561
Cdd:NF033189 481 GTTTFSGTVKQPLKAIFNAKFHVDGKETTKEVEAGNLLTEPAKPVKEGHTFIGWFDAQTGGTKWNFSTDKMPTNDIDLYA 560

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 562 QFSINSYTATFDNDGVTTSQTVDYQGLLQEPTAPTKEGYTFKGWYDAKTGGDKWDFATSKMPAKNITLYAQYSANSYTAT 641
Cdd:NF033189 561 QFSINSYTATFDNDGVTTSQTVDYQGLLQEPMAPTKEGYTFKGWYDAKTGGDKWDFATSKMPAKNITLYAQYSANSYTAT 640

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 642 FDVDGKSTTQAVDYQGLLKEPKAPTKAGYTFKGWYDEKTDGKKWDFATDKMPANDITLYAQFTKNPVAPPTTGGNTPPTT 721
Cdd:NF033189 641 FDVDGKTTTQAVDYQGLLKEPKTPTKAGYAFKGWYDEKTDGKKWDFATDKMPANDITLYAQFTKNPVAPPTTGGNTPPTT 720

                        730       740       750       760       770       780       790
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 403399437 722 NNGGNTTPPSANIPGSDTSNTSTGNSASTTSTMNAYDPYNSKEASLPTTGDSDNALYLLLGLLAVGTAMALTKKARASK 800
Cdd:NF033189 721 NNGGNTTPPSANIPGSDTSNTSTGNSASTTSTMNAYDPYNSKDASLPTTGDSDNALYLLIGLLAVGTAVALTKKARANK 799
internalin_H NF033188
InlH/InlC2 family class 1 internalin; Internalins, as found in the intracellular human ...
 1-636 9.25e-139

InlH/InlC2 family class 1 internalin; Internalins, as found in the intracellular human pathogen Listeria monocytogenes, are paralogous surface or secreted proteins with an N-terminal signal peptide, leucine-rich repeats, and usually a C-terminal LPXTG processing and cell surface anchoring site. See PMID:17764999 for a general discussion of internalins. Members of this family are internalin H (InlH), or internalin C2, two class 1 (LPXTG-type) internalins that are closely related, one apparently derived from the other through a recombination event.


Pssm-ID: 467985 [Multi-domain]  Cd Length: 548  Bit Score: 421.51  E-value: 9.25e-139
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437   1 MRKKRYVWLKSILVAILVFGSGVWINTSNGTNAQAATITQDTPINQIFTDTALAEKMKTVLGKTNVTDTVSQTDLDQVTT 80
Cdd:NF033188   1 MKKRWNSVFKIVLMVTAILGISLYVTTSQGVEVRAESITQPTAINVIFPDPALANAIKIAAGKSNVTDTVTQADLDGITT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437  81 LQADRLGIKSIDGVEYLNNLTqinfsnnqltditplknltklvdilmnnnqiaditplanltnltGLTLFNNQITDIDPL 160
Cdd:NF033188  81 LSAFGTGVTTIEGVQYLNNLI--------------------------------------------GLELKDNQITDLTPL 116

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 161 KNLTNLNRLELSSNTISDISALSGLTSLQQLSFgnqvtdlkplanlttlerldissnkvsdisvlakltnlesliaTNNQ 240
Cdd:NF033188 117 KNLTKITELELSGNPLKNVSAIAGLQSIKTLDL-------------------------------------------TSTQ 153

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 241 ISDITPLGILTNLDELSLNGNQLKDIGTLASLTNLTDLDLANNQISNLAPLSGLTKLTELKLGANQISNISPLAGLTALT 320
Cdd:NF033188 154 ITDVTPLAGLSNLQVLYLDLNQITNISPLAGLTNLQYLSIGNAQVSDLTPLANLSKLTTLKADDNKISDISPLASLPNLI 233

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 321 NLELNENQLEDISPISNLKNLTYLTLyfnnisdispvssltklqrlffynnkvsdvsslanltninwlsaghnqisdltp 400
Cdd:NF033188 234 EVHLKNNQISDVSPLANTSNLFIVTL------------------------------------------------------ 259

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 401 lanltritqlglNDQAWTNAPVNYKANVSIPNTVKNVTGALIAPATISDGGSYTEPDITWNLPSYTNEVSYTFSQPVTIG 480
Cdd:NF033188 260 ------------TNQTITNQPVFYQNNLVVPNVVKGPSGAPIAPATISDNGTYASPNLTWNLTSFINNVSYTFNQSVTFK 327

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 481 KGTTTFSGTVTQPLKAIFNVKFHVDGKETTKEVEAGNLLTEPAKPVKEGHTFVGWFDAQTGGTKWNFSTDKMPTNDINLY 560
Cdd:NF033188 328 NTTVPFSGTVTQPLTEAYTAVFDVDGKQTSVTVGANELIKEPTAPTKEGYTFTGWYDAKTGGNKWDFATDKMPAEDITLY 407

                        570       580       590       600       610       620       630
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 403399437 561 AQFSINSYTATFDNDGVTTSQTVDYQGLLQEPTAPTKEGYTFKGWYDAKTGGDKWDFATSKMPAKNITLYAQYSAN 636
Cdd:NF033188 408 AQFTINSYTASFDIDGKLTTQKVTYQSLLEEPVAPTKDGYTFTGWYDAKTGGNKWDFATGKMPAGNITLYAQFTKN 483
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
25-415 1.88e-44

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 165.88  E-value: 1.88e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437  25 INTSNGTNAQAATITQDTPINQIFTDTALAEKMKTVLGKTNVTDTVSQTDLDQVTTLQADRLGIKSIDGVEYLNNLTQIN 104
Cdd:COG4886    1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 105 FSNNQLTDITPLKNLTKLVDILMNNNQiaditPLANLTNLTGLTLFNNQITDIDP-LKNLTNLNRLELSSNTISDI-SAL 182
Cdd:COG4886   81 LLSLLLLGLTDLGDLTNLTELDLSGNE-----ELSNLTNLESLDLSGNQLTDLPEeLANLTNLKELDLSNNQLTDLpEPL 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 183 SGLTSLQQLSF-GNQVTDL-KPLANLTTLERLDISSNKVSDIS-VLAKLTNLESLIATNNQISDI-TPLGILTNLDELSL 258
Cdd:COG4886  156 GNLTNLKSLDLsNNQLTDLpEELGNLTNLKELDLSNNQITDLPePLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDL 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 259 NGNQLKDIGTLASLTNLTDLDLANNQISNLAPLSGLTKLTELKLGANQIS--NISPLAGLTALTNLELNENQLEDISPIS 336
Cdd:COG4886  236 SNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTdlKLKELELLLGLNSLLLLLLLLNLLELLI 315

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 403399437 337 NLKNLTYLTLYFNNISDISPVSSLTKLQRLFFYNNKVSDVSSLANLTNINWLSAGHNQISDLTPLANLTRITQLGLNDQ 415
Cdd:COG4886  316 LLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLL 394
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 97-289 7.45e-34

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 129.52  E-value: 7.45e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437  97 LNNLTQINFSNNQLTDITPLKNLTKLVDILMNNNQIADITPLANLTNLTGLTLFNNQITDIDPLKNLTNLNRLELSSNTI 176
Cdd:cd21340    1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 177 SDISALSGLTSLQQLSFGNQVTD-----------LKPLANltTLERLDISSNKVSDISVLAKLTNLESLIATNNQISDIt 245
Cdd:cd21340   81 SVVEGLENLTNLEELHIENQRLPpgekltfdprsLAALSN--SLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDL- 157

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 403399437 246 plgiltnlDELSlngnqlkdiGTLASLTNLTDLDLANNQISNLA 289
Cdd:cd21340  158 --------EELL---------DLLSSWPSLRELDLTGNPVCKKP 184
LRR_adjacent pfam08191
LRR adjacent; These are small, all beta strand domains, structurally described for the protein ...
 439-495 1.22e-24

LRR adjacent; These are small, all beta strand domains, structurally described for the protein Internalin (InlA) and related proteins InlB, InlE, InlH from the pathogenic bacterium Listeria monocytogenes. Their function appears to be mainly structural: They are fused to the C-terminal end of leucine-rich repeats (LRR), significantly stabilising the LRR, and forming a common rigid entity with the LRR. They are themselves not involved in protein-protein-interactions but help to present the adjacent LRR-domain for this purpose. These domains belong to the family of Ig-like domains in that they consist of two sandwiched beta sheets that follow the classical connectivity of Ig-domains. The beta strands in one of the sheets is, however, much smaller than in most standard Ig-like domains, making it somewhat of an outlier.


Pssm-ID: 369739 [Multi-domain]  Cd Length: 57  Bit Score: 97.05  E-value: 1.22e-24
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 403399437  439 GALIAPATISDGGSYTEPDITWNLPSYTNEVSYTFSQPVTIGKGTTTFSGTVTQPLK 495
Cdd:pfam08191   1 GSLVAPSTISNNGTYADPNITWNLPSFTSEVSYTFNQPITIGKGTATFSGTVTQPLK 57
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 162-419 5.74e-15

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 79.12  E-value: 5.74e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 162 NLTNLNRLELSSNTIS-DISALS-GLTSLQQLSFG-NQVTDLKPLANLTT---LERLDISSNKVSDISVLAKLTNLESLI 235
Cdd:PLN00113  67 NSSRVVSIDLSGKNISgKISSAIfRLPYIQTINLSnNQLSGPIPDDIFTTsssLRYLNLSNNNFTGSIPRGSIPNLETLD 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 236 ATNNQISDITP--LGILTNLDELSLNGNQL--KDIGTLASLTNLTDLDLANNQISNLAPlSGLTKLTELK---LGANQIS 308
Cdd:PLN00113 147 LSNNMLSGEIPndIGSFSSLKVLDLGGNVLvgKIPNSLTNLTSLEFLTLASNQLVGQIP-RELGQMKSLKwiyLGYNNLS 225

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 309 NISP--LAGLTALTNLELNENQLEDISPIS--NLKNLTYLTLYFNNISDISPVS--SLTKLQRLFFYNNKVS-DVSSL-A 380
Cdd:PLN00113 226 GEIPyeIGGLTSLNHLDLVYNNLTGPIPSSlgNLKNLQYLFLYQNKLSGPIPPSifSLQKLISLDLSDNSLSgEIPELvI 305

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 403399437 381 NLTNINWLSAGHNQISDLTP--LANLTRITQLglndQAWTN 419
Cdd:PLN00113 306 QLQNLEILHLFSNNFTGKIPvaLTSLPRLQVL----QLWSN 342
List_Bact_rpt TIGR02543
Listeria/Bacterioides repeat; This model describes a conserved core region, about 43 residues ...
 665-707 4.64e-11

Listeria/Bacterioides repeat; This model describes a conserved core region, about 43 residues in length, of at least two families of tandem repeats. These include 78-residue repeats from 2 to 15 in number, in some proteins of Bacteroides forsythus ATCC 43037, and 70-residue repeats in families of internalins of Listeria species. Single copies are found in proteins of Fibrobacter succinogenes, Geobacter sulfurreducens, and a few bacteria. [Unknown function, General]


Pssm-ID: 274189 [Multi-domain]  Cd Length: 43  Bit Score: 58.02  E-value: 4.64e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 403399437  665 PTKAGYTFKGWYDEKTDGKKWDFATDKMPANDITLYAQFTKNP 707
Cdd:TIGR02543   1 PTKTGYTFVGWTGDSTGTPVKNFTIPSGSTGDLTLYAKWTPNT 43
 
Name Accession Description Interval E-value
internalin_A NF033189
class 1 internalin InlA; Internalins, as found in the intracellular human pathogen Listeria ...
 2-800 0e+00

class 1 internalin InlA; Internalins, as found in the intracellular human pathogen Listeria monocytogenes, are paralogous surface or secreted proteins with an N-terminal signal peptide, leucine-rich repeats, and usually a C-terminal LPXTG processing and cell surface anchoring site. See PMID:17764999 for a general discussion of internalins. Members of this family are internalin A (InlA), a class 1 (LPXTG-type) internalin.


Pssm-ID: 380193 [Multi-domain]  Cd Length: 799  Bit Score: 1369.10  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437   2 RKKRYVWLKSILVAILVFGSGVWINTSNGTNAQAATITQDTPINQIFTDTALAEKMKTVLGKTNVTDTVSQTDLDQVTTL 81
Cdd:NF033189   1 RKKRYVWLKSILVAILVFGSGLWINTSNGTNAQAATITQDTPINQIFTDTALAEKMKTVLGKTNVTDTVSQTDLDQVTTL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437  82 QADRLGIKSIDGVEYLNNLTQINFSNNQLTDITPLKNLTKLVDILMNNNQIADITPLANLTNLTGLTLFNNQITDIDPLK 161
Cdd:NF033189  81 QADRLGIKSIDGLEYLNNLTQINFSNNQLTDITPLKDLTKLVDILMNNNQIADITPLANLSNLTGLTLFNNQITDIDPLK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 162 NLTNLNRLELSSNTISDISALSGLTSLQQLSFGNQVTDLKPLANLTTLERLDISSNKVSDISVLAKLTNLESLIATNNQI 241
Cdd:NF033189 161 NLTNLNRLELSSNTISDISALSGLTSLQQLSFGNQVTDLKPLANLTTLERLDISSNKVSDISVLAKLTNLESLIATNNQI 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 242 SDITPLGILTNLDELSLNGNQLKDIGTLASLTNLTDLDLANNQISNLAPLSGLTKLTELKLGANQISNISPLAGLTALTN 321
Cdd:NF033189 241 SDITPLGILTNLDELSLNGNQLKDIGTLASLTNLTDLDLANNQISNLAPLSGLTKLTELKLGANQISNISPLAGLTALTN 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 322 LELNENQLEDISPISNLKNLTYLTLYFNNISDISPVSSLTKLQRLFFYNNKVSDVSSLANLTNINWLSAGHNQISDLTPL 401
Cdd:NF033189 321 LELNENQLEDISPISNLKNLTYLTLYFNNISDISPVSSLTKLQRLFFYNNKVSDVSSLANLTNINWLSAGHNQISDLTPL 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 402 ANLTRITQLGLNDQAWTNAPVNYKANVSIPNTVKNVTGALIAPATISDGGSYTEPDITWNLPSYTNEVSYTFSQPVTIGK 481
Cdd:NF033189 401 ANLTRITQLGLNDQAWTNPPVNYKVNVSIPNTVKNVTGALIAPATISDGGSYAEPDITWNLPSYTNEVSYTFNQSVTIGK 480

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 482 GTTTFSGTVTQPLKAIFNVKFHVDGKETTKEVEAGNLLTEPAKPVKEGHTFVGWFDAQTGGTKWNFSTDKMPTNDINLYA 561
Cdd:NF033189 481 GTTTFSGTVKQPLKAIFNAKFHVDGKETTKEVEAGNLLTEPAKPVKEGHTFIGWFDAQTGGTKWNFSTDKMPTNDIDLYA 560

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 562 QFSINSYTATFDNDGVTTSQTVDYQGLLQEPTAPTKEGYTFKGWYDAKTGGDKWDFATSKMPAKNITLYAQYSANSYTAT 641
Cdd:NF033189 561 QFSINSYTATFDNDGVTTSQTVDYQGLLQEPMAPTKEGYTFKGWYDAKTGGDKWDFATSKMPAKNITLYAQYSANSYTAT 640

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 642 FDVDGKSTTQAVDYQGLLKEPKAPTKAGYTFKGWYDEKTDGKKWDFATDKMPANDITLYAQFTKNPVAPPTTGGNTPPTT 721
Cdd:NF033189 641 FDVDGKTTTQAVDYQGLLKEPKTPTKAGYAFKGWYDEKTDGKKWDFATDKMPANDITLYAQFTKNPVAPPTTGGNTPPTT 720

                        730       740       750       760       770       780       790
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 403399437 722 NNGGNTTPPSANIPGSDTSNTSTGNSASTTSTMNAYDPYNSKEASLPTTGDSDNALYLLLGLLAVGTAMALTKKARASK 800
Cdd:NF033189 721 NNGGNTTPPSANIPGSDTSNTSTGNSASTTSTMNAYDPYNSKDASLPTTGDSDNALYLLIGLLAVGTAVALTKKARANK 799
internalin_H NF033188
InlH/InlC2 family class 1 internalin; Internalins, as found in the intracellular human ...
 1-636 9.25e-139

InlH/InlC2 family class 1 internalin; Internalins, as found in the intracellular human pathogen Listeria monocytogenes, are paralogous surface or secreted proteins with an N-terminal signal peptide, leucine-rich repeats, and usually a C-terminal LPXTG processing and cell surface anchoring site. See PMID:17764999 for a general discussion of internalins. Members of this family are internalin H (InlH), or internalin C2, two class 1 (LPXTG-type) internalins that are closely related, one apparently derived from the other through a recombination event.


Pssm-ID: 467985 [Multi-domain]  Cd Length: 548  Bit Score: 421.51  E-value: 9.25e-139
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437   1 MRKKRYVWLKSILVAILVFGSGVWINTSNGTNAQAATITQDTPINQIFTDTALAEKMKTVLGKTNVTDTVSQTDLDQVTT 80
Cdd:NF033188   1 MKKRWNSVFKIVLMVTAILGISLYVTTSQGVEVRAESITQPTAINVIFPDPALANAIKIAAGKSNVTDTVTQADLDGITT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437  81 LQADRLGIKSIDGVEYLNNLTqinfsnnqltditplknltklvdilmnnnqiaditplanltnltGLTLFNNQITDIDPL 160
Cdd:NF033188  81 LSAFGTGVTTIEGVQYLNNLI--------------------------------------------GLELKDNQITDLTPL 116

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 161 KNLTNLNRLELSSNTISDISALSGLTSLQQLSFgnqvtdlkplanlttlerldissnkvsdisvlakltnlesliaTNNQ 240
Cdd:NF033188 117 KNLTKITELELSGNPLKNVSAIAGLQSIKTLDL-------------------------------------------TSTQ 153

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 241 ISDITPLGILTNLDELSLNGNQLKDIGTLASLTNLTDLDLANNQISNLAPLSGLTKLTELKLGANQISNISPLAGLTALT 320
Cdd:NF033188 154 ITDVTPLAGLSNLQVLYLDLNQITNISPLAGLTNLQYLSIGNAQVSDLTPLANLSKLTTLKADDNKISDISPLASLPNLI 233

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 321 NLELNENQLEDISPISNLKNLTYLTLyfnnisdispvssltklqrlffynnkvsdvsslanltninwlsaghnqisdltp 400
Cdd:NF033188 234 EVHLKNNQISDVSPLANTSNLFIVTL------------------------------------------------------ 259

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 401 lanltritqlglNDQAWTNAPVNYKANVSIPNTVKNVTGALIAPATISDGGSYTEPDITWNLPSYTNEVSYTFSQPVTIG 480
Cdd:NF033188 260 ------------TNQTITNQPVFYQNNLVVPNVVKGPSGAPIAPATISDNGTYASPNLTWNLTSFINNVSYTFNQSVTFK 327

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 481 KGTTTFSGTVTQPLKAIFNVKFHVDGKETTKEVEAGNLLTEPAKPVKEGHTFVGWFDAQTGGTKWNFSTDKMPTNDINLY 560
Cdd:NF033188 328 NTTVPFSGTVTQPLTEAYTAVFDVDGKQTSVTVGANELIKEPTAPTKEGYTFTGWYDAKTGGNKWDFATDKMPAEDITLY 407

                        570       580       590       600       610       620       630
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 403399437 561 AQFSINSYTATFDNDGVTTSQTVDYQGLLQEPTAPTKEGYTFKGWYDAKTGGDKWDFATSKMPAKNITLYAQYSAN 636
Cdd:NF033188 408 AQFTINSYTASFDIDGKLTTQKVTYQSLLEEPVAPTKDGYTFTGWYDAKTGGNKWDFATGKMPAGNITLYAQFTKN 483
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
25-415 1.88e-44

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 165.88  E-value: 1.88e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437  25 INTSNGTNAQAATITQDTPINQIFTDTALAEKMKTVLGKTNVTDTVSQTDLDQVTTLQADRLGIKSIDGVEYLNNLTQIN 104
Cdd:COG4886    1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 105 FSNNQLTDITPLKNLTKLVDILMNNNQiaditPLANLTNLTGLTLFNNQITDIDP-LKNLTNLNRLELSSNTISDI-SAL 182
Cdd:COG4886   81 LLSLLLLGLTDLGDLTNLTELDLSGNE-----ELSNLTNLESLDLSGNQLTDLPEeLANLTNLKELDLSNNQLTDLpEPL 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 183 SGLTSLQQLSF-GNQVTDL-KPLANLTTLERLDISSNKVSDIS-VLAKLTNLESLIATNNQISDI-TPLGILTNLDELSL 258
Cdd:COG4886  156 GNLTNLKSLDLsNNQLTDLpEELGNLTNLKELDLSNNQITDLPePLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDL 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 259 NGNQLKDIGTLASLTNLTDLDLANNQISNLAPLSGLTKLTELKLGANQIS--NISPLAGLTALTNLELNENQLEDISPIS 336
Cdd:COG4886  236 SNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTdlKLKELELLLGLNSLLLLLLLLNLLELLI 315

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 403399437 337 NLKNLTYLTLYFNNISDISPVSSLTKLQRLFFYNNKVSDVSSLANLTNINWLSAGHNQISDLTPLANLTRITQLGLNDQ 415
Cdd:COG4886  316 LLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLL 394
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
138-473 1.71e-40

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 154.32  E-value: 1.71e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 138 LANLTNLTGLTLFNNQITDIDPLKNLTNLNRLELSSNTISDISALSGLTSLQQLSFGNQVTDLKPLANLTTLERLDISSN 217
Cdd:COG4886    5 LLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 218 KVSDISVLAKLTNLESLIatnnqISDITPLGILTNLDELSLNGNQLKDIG-TLASLTNLTDLDLANNQISNL-APLSGLT 295
Cdd:COG4886   85 LLLGLTDLGDLTNLTELD-----LSGNEELSNLTNLESLDLSGNQLTDLPeELANLTNLKELDLSNNQLTDLpEPLGNLT 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 296 KLTELKLGANQISNIS-PLAGLTALTNLELNENQLEDIS-PISNLKNLTYLTLYFNNISDIS-PVSSLTKLQRLFFYNNK 372
Cdd:COG4886  160 NLKSLDLSNNQLTDLPeELGNLTNLKELDLSNNQITDLPePLGNLTNLEELDLSGNQLTDLPePLANLTNLETLDLSNNQ 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 373 VSDVSSLANLTNINWLSAGHNQISDLTPLANLTRITQLGLNDQAWTNAPVNYKANVSIPNTVKNVTGALIAPATISDGGS 452
Cdd:COG4886  240 LTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLL 319

                        330       340
                 ....*....|....*....|.
gi 403399437 453 YTEPDITWNLPSYTNEVSYTF 473
Cdd:COG4886  320 LTTLLLLLLLLKGLLVTLTTL 340
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 97-289 7.45e-34

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 129.52  E-value: 7.45e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437  97 LNNLTQINFSNNQLTDITPLKNLTKLVDILMNNNQIADITPLANLTNLTGLTLFNNQITDIDPLKNLTNLNRLELSSNTI 176
Cdd:cd21340    1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 177 SDISALSGLTSLQQLSFGNQVTD-----------LKPLANltTLERLDISSNKVSDISVLAKLTNLESLIATNNQISDIt 245
Cdd:cd21340   81 SVVEGLENLTNLEELHIENQRLPpgekltfdprsLAALSN--SLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDL- 157

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 403399437 246 plgiltnlDELSlngnqlkdiGTLASLTNLTDLDLANNQISNLA 289
Cdd:cd21340  158 --------EELL---------DLLSSWPSLRELDLTGNPVCKKP 184
LRR_adjacent pfam08191
LRR adjacent; These are small, all beta strand domains, structurally described for the protein ...
 439-495 1.22e-24

LRR adjacent; These are small, all beta strand domains, structurally described for the protein Internalin (InlA) and related proteins InlB, InlE, InlH from the pathogenic bacterium Listeria monocytogenes. Their function appears to be mainly structural: They are fused to the C-terminal end of leucine-rich repeats (LRR), significantly stabilising the LRR, and forming a common rigid entity with the LRR. They are themselves not involved in protein-protein-interactions but help to present the adjacent LRR-domain for this purpose. These domains belong to the family of Ig-like domains in that they consist of two sandwiched beta sheets that follow the classical connectivity of Ig-domains. The beta strands in one of the sheets is, however, much smaller than in most standard Ig-like domains, making it somewhat of an outlier.


Pssm-ID: 369739 [Multi-domain]  Cd Length: 57  Bit Score: 97.05  E-value: 1.22e-24
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 403399437  439 GALIAPATISDGGSYTEPDITWNLPSYTNEVSYTFSQPVTIGKGTTTFSGTVTQPLK 495
Cdd:pfam08191   1 GSLVAPSTISNNGTYADPNITWNLPSFTSEVSYTFNQPITIGKGTATFSGTVTQPLK 57
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 212-374 7.85e-24

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 100.63  E-value: 7.85e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 212 LDISSNKVSDISVLAKLTNLESLIATNNQISDITPLGILTNLDELSLNGNQLKDIGTLASLTNLTDLDLANNQISNLAPL 291
Cdd:cd21340    7 LYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 292 SGLTKLTELKLGANQISN----------ISPLAGltALTNLELNENQLEDISPISNLKNLTYLTLYFNNISDIS----PV 357
Cdd:cd21340   87 ENLTNLEELHIENQRLPPgekltfdprsLAALSN--SLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEelldLL 164

                        170
                 ....*....|....*..
gi 403399437 358 SSLTKLQRLFFYNNKVS 374
Cdd:cd21340  165 SSWPSLRELDLTGNPVC 181
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 225-382 2.43e-23

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 99.09  E-value: 2.43e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 225 LAKLTNLeSLiaTNNQISDITPLGILTNLDELSLNGNQLKDIGTLASLTNLTDLDLANNQISNLAPLSGLTKLTELKLGA 304
Cdd:cd21340    1 LKRITHL-YL--NDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGG 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 305 NQISNISPLAGLTALTNLELnENQ---------LEDISPISNLKNLTYLTLYFNNISDISPVSSLTKLQRLFFYNNKVSD 375
Cdd:cd21340   78 NRISVVEGLENLTNLEELHI-ENQrlppgekltFDPRSLAALSNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISD 156


                 ....*..
gi 403399437 376 VSSLANL 382
Cdd:cd21340  157 LEELLDL 163
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 256-404 3.15e-23

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 98.70  E-value: 3.15e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 256 LSLNGNQLKDIGTLASLTNLTDLDLANNQISNLAPLSGLTKLTELKLGANQISNISPLAGLTALTNLELNENQledISPI 335
Cdd:cd21340    7 LYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNR---ISVV 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 336 SNLKNLTYLT-LYFNN---------ISDISPVSSLTK-LQRLFFYNNKVSDVSSLANLTNINWLSAGHNQISDLTPLANL 404
Cdd:cd21340   84 EGLENLTNLEeLHIENqrlppgeklTFDPRSLAALSNsLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLDL 163
Flg_new pfam09479
Listeria-Bacteroides repeat domain (List_Bact_rpt); This model describes a conserved core ...
 568-632 8.42e-22

Listeria-Bacteroides repeat domain (List_Bact_rpt); This model describes a conserved core region of about 43 residues which occurs in more than 400 mostly secreted or cell surface-located proteins from over 300 eubacterial and few archaeal species. These proteins contain between one and 34 copies of the domain that often occur in tandem arrays with up to more than 20 copies.


Pssm-ID: 462813 [Multi-domain]  Cd Length: 65  Bit Score: 89.22  E-value: 8.42e-22
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 403399437  568 YTATFDNDGVTTSQTVDYQGLLQEPTAPTKEGYTFKGWYDAKTGGDKWDFATSKMPAKNITLYAQ 632
Cdd:pfam09479   1 YTVTFDANGGTVSQTVTYGTTITLPADPTKEGYTFAGWYTDSDGTTKYTFGTDVTPTGDITLYAK 65
Flg_new pfam09479
Listeria-Bacteroides repeat domain (List_Bact_rpt); This model describes a conserved core ...
 638-702 6.77e-21

Listeria-Bacteroides repeat domain (List_Bact_rpt); This model describes a conserved core region of about 43 residues which occurs in more than 400 mostly secreted or cell surface-located proteins from over 300 eubacterial and few archaeal species. These proteins contain between one and 34 copies of the domain that often occur in tandem arrays with up to more than 20 copies.


Pssm-ID: 462813 [Multi-domain]  Cd Length: 65  Bit Score: 86.91  E-value: 6.77e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 403399437  638 YTATFDVDGKSTTQAVDYQGLLKEPKAPTKAGYTFKGWYDEKTDGKKWDFATDKMPANDITLYAQ 702
Cdd:pfam09479   1 YTVTFDANGGTVSQTVTYGTTITLPADPTKEGYTFAGWYTDSDGTTKYTFGTDVTPTGDITLYAK 65
Flg_new pfam09479
Listeria-Bacteroides repeat domain (List_Bact_rpt); This model describes a conserved core ...
 498-562 2.45e-17

Listeria-Bacteroides repeat domain (List_Bact_rpt); This model describes a conserved core region of about 43 residues which occurs in more than 400 mostly secreted or cell surface-located proteins from over 300 eubacterial and few archaeal species. These proteins contain between one and 34 copies of the domain that often occur in tandem arrays with up to more than 20 copies.


Pssm-ID: 462813 [Multi-domain]  Cd Length: 65  Bit Score: 76.51  E-value: 2.45e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 403399437  498 FNVKFHVDGKETTKEVEAGNLLTEPAKPVKEGHTFVGWFDAQTGGTKWNFSTDKMPTNDINLYAQ 562
Cdd:pfam09479   1 YTVTFDANGGTVSQTVTYGTTITLPADPTKEGYTFAGWYTDSDGTTKYTFGTDVTPTGDITLYAK 65
Internalin_N pfam12354
Bacterial adhesion/invasion protein N terminal; This domain family is found in bacteria, and ...
 9-58 6.53e-17

Bacterial adhesion/invasion protein N terminal; This domain family is found in bacteria, and is approximately 60 amino acids in length. The family is found in association with pfam00560, pfam08191, pfam09479. There are two completely conserved residues (I and F) that may be functionally important. Internalin mediates bacterial adhesion and invasion of epithelial cells in the human intestine through specific interaction with its host cell receptor E-cadherin. This family is the N terminal of internalin, the cap domain of the protein. The cap domain is conserved between different internalin types. The cap domain does not interact with E cadherin, therefore its function is presumably structural: capping the hydrophobic core.


Pssm-ID: 289150  Cd Length: 50  Bit Score: 75.06  E-value: 6.53e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 403399437    9 LKSILVAILVFGSGVWINTSNGTNAQAATITQDTPINQIFTDTALAEKMK 58
Cdd:pfam12354   1 LKKLLTLTLVLLLSLWVLTSNGTDVQAESITPPAPINQIFPDPALAEEVK 50
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 142-309 3.40e-15

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 78.68  E-value: 3.40e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 142 TNLTGLTLFNNQITDI------DPLKNLTNLNRLELSSNTISD------ISALSGLTSLQQLSF-GNQVTD------LKP 202
Cdd:COG5238  180 NSVETVYLGCNQIGDEgieelaEALTQNTTVTTLWLKRNPIGDegaeilAEALKGNKSLTTLDLsNNQIGDegvialAEA 259

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 203 LANLTTLERLDISSNKVSD------ISVLAKLTNLESLIATNNQISDITPLGILTNLD------ELSLNGNQLKDIG--- 267
Cdd:COG5238  260 LKNNTTVETLYLSGNQIGAegaialAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQgnktlhTLNLAYNGIGAQGaia 339

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 403399437 268 ---TLASLTNLTDLDLANNQISN-----LAP-LSGLTKLTELKLGANQISN 309
Cdd:COG5238  340 lakALQENTTLHSLDLSDNQIGDegaiaLAKyLEGNTTLRELNLGKNNIGK 390
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 162-419 5.74e-15

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 79.12  E-value: 5.74e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 162 NLTNLNRLELSSNTIS-DISALS-GLTSLQQLSFG-NQVTDLKPLANLTT---LERLDISSNKVSDISVLAKLTNLESLI 235
Cdd:PLN00113  67 NSSRVVSIDLSGKNISgKISSAIfRLPYIQTINLSnNQLSGPIPDDIFTTsssLRYLNLSNNNFTGSIPRGSIPNLETLD 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 236 ATNNQISDITP--LGILTNLDELSLNGNQL--KDIGTLASLTNLTDLDLANNQISNLAPlSGLTKLTELK---LGANQIS 308
Cdd:PLN00113 147 LSNNMLSGEIPndIGSFSSLKVLDLGGNVLvgKIPNSLTNLTSLEFLTLASNQLVGQIP-RELGQMKSLKwiyLGYNNLS 225

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 309 NISP--LAGLTALTNLELNENQLEDISPIS--NLKNLTYLTLYFNNISDISPVS--SLTKLQRLFFYNNKVS-DVSSL-A 380
Cdd:PLN00113 226 GEIPyeIGGLTSLNHLDLVYNNLTGPIPSSlgNLKNLQYLFLYQNKLSGPIPPSifSLQKLISLDLSDNSLSgEIPELvI 305

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 403399437 381 NLTNINWLSAGHNQISDLTP--LANLTRITQLglndQAWTN 419
Cdd:PLN00113 306 QLQNLEILHLFSNNFTGKIPvaLTSLPRLQVL----QLWSN 342
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 88-220 1.70e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 70.59  E-value: 1.70e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437  88 IKSIDGVEYLNNLTQINFSNNQLTDITPLKNLTKLVDILMNNNQIAD----------ITPLANltNLTGLTLFNNQITDI 157
Cdd:cd21340   58 IEKIENLENLVNLKKLYLGGNRISVVEGLENLTNLEELHIENQRLPPgekltfdprsLAALSN--SLRVLNISGNNIDSL 135

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 403399437 158 DPLKNLTNLNRLELSSNTISDISALSGLtslqqlsfgnqvtdlkpLANLTTLERLDISSNKVS 220
Cdd:cd21340  136 EPLAPLRNLEQLDASNNQISDLEELLDL-----------------LSSWPSLRELDLTGNPVC 181
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 100-374 6.02e-13

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 72.57  E-value: 6.02e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 100 LTQINFSNNQLTDITPlknltklvdilmnnnqiADITPLAnlTNLTGLTLFNNQITDIDPLKNLTNLNRLELSSNTIS-- 177
Cdd:PLN00113  95 IQTINLSNNQLSGPIP-----------------DDIFTTS--SSLRYLNLSNNNFTGSIPRGSIPNLETLDLSNNMLSge 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 178 ---DISALSGLTSLQQlsFGNQVTDLKP--LANLTTLERLDISSNK-VSDISV-LAKLTNLESLIATNNQISDITPlgil 250
Cdd:PLN00113 156 ipnDIGSFSSLKVLDL--GGNVLVGKIPnsLTNLTSLEFLTLASNQlVGQIPReLGQMKSLKWIYLGYNNLSGEIP---- 229

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 251 tnldelslngnqlKDIGTLASLTNltdLDLANNQISNLAP--LSGLTKLTELKLGANQISNISP--LAGLTALTNLELNE 326
Cdd:PLN00113 230 -------------YEIGGLTSLNH---LDLVYNNLTGPIPssLGNLKNLQYLFLYQNKLSGPIPpsIFSLQKLISLDLSD 293

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 403399437 327 NQLEDISP--ISNLKNLTYLTLYFNNISDISPV--SSLTKLQRLFFYNNKVS 374
Cdd:PLN00113 294 NSLSGEIPelVIQLQNLEILHLFSNNFTGKIPValTSLPRLQVLQLWSNKFS 345
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 316-415 6.57e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 68.66  E-value: 6.57e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 316 LTALTNLELNENQLEDISPISNLKNLTYLTLYFNNISDISPVSSLTKLQRLFFYNNKVSDVSSLANLTNINWLSAGHNQI 395
Cdd:cd21340    1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRI 80

                         90       100
                 ....*....|....*....|
gi 403399437 396 SDLTPLANLTRITQLGLNDQ 415
Cdd:cd21340   81 SVVEGLENLTNLEELHIENQ 100
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 118-421 6.99e-13

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 71.36  E-value: 6.99e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 118 NLTKLVDILMNNNQIADITPLANLTNLTGLT------LFNNQITDIDPLKNLTNLNRLELSSNTISD-ISALSGLTSLQQ 190
Cdd:COG5238   85 FPTQLLVVDWEGAEEVSPVALAETATAVATPppdlrrIMAKTLEDSLILYLALPRRINLIQVLKDPLgGNAVHLLGLAAR 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 191 LSFGNQVTDLKPLANlTTLERLDISSNKVSD--ISVLAKL----TNLESLIATNNQISD------ITPLGILTNLDELSL 258
Cdd:COG5238  165 LGLLAAISMAKALQN-NSVETVYLGCNQIGDegIEELAEAltqnTTVTTLWLKRNPIGDegaeilAEALKGNKSLTTLDL 243

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 259 NGNQLKDIG------TLASLTNLTDLDLANNQISN-----LAP-LSGLTKLTELKLGANQISN------ISPLAGLTALT 320
Cdd:COG5238  244 SNNQIGDEGvialaeALKNNTTVETLYLSGNQIGAegaiaLAKaLQGNTTLTSLDLSVNRIGDegaialAEGLQGNKTLH 323

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 321 NLELNENQLED---ISPISNLK---NLTYLTLYFNNISDISpVSSLTKlqrlffynnkvsdvsSLANLTNINWLSAGHNQ 394
Cdd:COG5238  324 TLNLAYNGIGAqgaIALAKALQentTLHSLDLSDNQIGDEG-AIALAK---------------YLEGNTTLRELNLGKNN 387

                        330       340       350
                 ....*....|....*....|....*....|..
gi 403399437 395 ISD-----LTPLANLTRITQLGLNDQAWTNAP 421
Cdd:COG5238  388 IGKqgaeaLIDALQTNRLHTLILDGNLIGAEA 419
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 99-353 1.40e-12

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 70.59  E-value: 1.40e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437  99 NLTQINFSNNQLTDITPLKNLTKLV-------DILMNNNQIADITPLANL---TNLTGLTLFNNQITDIDPLKNLTNLNR 168
Cdd:COG5238   88 QLLVVDWEGAEEVSPVALAETATAVatpppdlRRIMAKTLEDSLILYLALprrINLIQVLKDPLGGNAVHLLGLAARLGL 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 169 LELssntISDISALSGlTSLQQLSFGNQVTDLKPLANL-------TTLERLDISSNKVSD------ISVLAKLTNLESLI 235
Cdd:COG5238  168 LAA----ISMAKALQN-NSVETVYLGCNQIGDEGIEELaealtqnTTVTTLWLKRNPIGDegaeilAEALKGNKSLTTLD 242

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 236 ATNNQISD------ITPLGILTNLDELSLNGNQLKDIG------TLASLTNLTDLDLANNQISN-----LAP-LSGLTKL 297
Cdd:COG5238  243 LSNNQIGDegvialAEALKNNTTVETLYLSGNQIGAEGaialakALQGNTTLTSLDLSVNRIGDegaiaLAEgLQGNKTL 322

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 403399437 298 TELKLGANQISN------ISPLAGLTALTNLELNENQLEDISPIS------NLKNLTYLTLYFNNISD 353
Cdd:COG5238  323 HTLNLAYNGIGAqgaialAKALQENTTLHSLDLSDNQIGDEGAIAlakyleGNTTLRELNLGKNNIGK 390
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 99-396 1.42e-11

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 68.34  E-value: 1.42e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437  99 NLTQINFSNNQLTDITPLKNLTKLVDILMNNNQIADITP--LANLTNLTGLTLFNNQITDIDP--LKNLTNLNRLELSSN 174
Cdd:PLN00113 119 SLRYLNLSNNNFTGSIPRGSIPNLETLDLSNNMLSGEIPndIGSFSSLKVLDLGGNVLVGKIPnsLTNLTSLEFLTLASN 198

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 175 TISD--ISALSGLTSLQQLSFG-NQVTDLKP--LANLTTLERLDISSNKVSD--ISVLAKLTNLESLIATNNQISDITPL 247
Cdd:PLN00113 199 QLVGqiPRELGQMKSLKWIYLGyNNLSGEIPyeIGGLTSLNHLDLVYNNLTGpiPSSLGNLKNLQYLFLYQNKLSGPIPP 278

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 248 GI--LTNLDELSLNGNQLK-DIGTL-ASLTNLTDLDLANNQISNLAP--LSGLTKLTELKLGANQISNISP--LAGLTAL 319
Cdd:PLN00113 279 SIfsLQKLISLDLSDNSLSgEIPELvIQLQNLEILHLFSNNFTGKIPvaLTSLPRLQVLQLWSNKFSGEIPknLGKHNNL 358

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 320 TNLELNENQLEDISP--ISNLKNLTYLTLYFNNISDISP--VSSLTKLQRLFFYNNKVS-DVSS-LANLTNINWLSAGHN 393
Cdd:PLN00113 359 TVLDLSTNNLTGEIPegLCSSGNLFKLILFSNSLEGEIPksLGACRSLRRVRLQDNSFSgELPSeFTKLPLVYFLDISNN 438


                 ...
gi 403399437 394 QIS 396
Cdd:PLN00113 439 NLQ 441
List_Bact_rpt TIGR02543
Listeria/Bacterioides repeat; This model describes a conserved core region, about 43 residues ...
 665-707 4.64e-11

Listeria/Bacterioides repeat; This model describes a conserved core region, about 43 residues in length, of at least two families of tandem repeats. These include 78-residue repeats from 2 to 15 in number, in some proteins of Bacteroides forsythus ATCC 43037, and 70-residue repeats in families of internalins of Listeria species. Single copies are found in proteins of Fibrobacter succinogenes, Geobacter sulfurreducens, and a few bacteria. [Unknown function, General]


Pssm-ID: 274189 [Multi-domain]  Cd Length: 43  Bit Score: 58.02  E-value: 4.64e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 403399437  665 PTKAGYTFKGWYDEKTDGKKWDFATDKMPANDITLYAQFTKNP 707
Cdd:TIGR02543   1 PTKTGYTFVGWTGDSTGTPVKNFTIPSGSTGDLTLYAKWTPNT 43
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 98-329 3.26e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 63.71  E-value: 3.26e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437  98 NNLTQINFSNNQLTDITPlknltklvdilmnnnqiadiTPLANLTNLTGLTLFNNQITDIDP--LKNLTNLNRLELSSNT 175
Cdd:PLN00113 356 NNLTVLDLSTNNLTGEIP--------------------EGLCSSGNLFKLILFSNSLEGEIPksLGACRSLRRVRLQDNS 415

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 176 IS-DISalSGLTSLQQLSFGNqVTDLKPLANLTT-------LERLDISSNKVS-DISVLAKLTNLESLIATNNQISDITP 246
Cdd:PLN00113 416 FSgELP--SEFTKLPLVYFLD-ISNNNLQGRINSrkwdmpsLQMLSLARNKFFgGLPDSFGSKRLENLDLSRNQFSGAVP 492

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 247 --LGILTNLDELSLNGNQLKDI--GTLASLTNLTDLDLANNQISNLAPLS--GLTKLTELKLGANQISNISP--LAGLTA 318
Cdd:PLN00113 493 rkLGSLSELMQLKLSENKLSGEipDELSSCKKLVSLDLSHNQLSGQIPASfsEMPVLSQLDLSQNQLSGEIPknLGNVES 572

                        250
                 ....*....|.
gi 403399437 319 LTNLELNENQL 329
Cdd:PLN00113 573 LVQVNISHNHL 583
List_Bact_rpt TIGR02543
Listeria/Bacterioides repeat; This model describes a conserved core region, about 43 residues ...
 525-567 4.80e-10

Listeria/Bacterioides repeat; This model describes a conserved core region, about 43 residues in length, of at least two families of tandem repeats. These include 78-residue repeats from 2 to 15 in number, in some proteins of Bacteroides forsythus ATCC 43037, and 70-residue repeats in families of internalins of Listeria species. Single copies are found in proteins of Fibrobacter succinogenes, Geobacter sulfurreducens, and a few bacteria. [Unknown function, General]


Pssm-ID: 274189 [Multi-domain]  Cd Length: 43  Bit Score: 55.32  E-value: 4.80e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 403399437  525 PVKEGHTFVGWFDAQTGGTKWNFSTDKMPTNDINLYAQFSINS 567
Cdd:TIGR02543   1 PTKTGYTFVGWTGDSTGTPVKNFTIPSGSTGDLTLYAKWTPNT 43
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 160-329 2.12e-09

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 59.68  E-value: 2.12e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 160 LKNLTNLNRLELSSNTISD-----ISALSGLTSLQQLSFGNQVTDLKPLANLTT--------LERLDISSNKVSDIS--- 223
Cdd:cd00116   77 LTKGCGLQELDLSDNALGPdgcgvLESLLRSSSLQELKLNNNGLGDRGLRLLAKglkdlppaLEKLVLGRNRLEGAScea 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 224 ---VLAKLTNLESLIATNNQISD--ITPLG----ILTNLDELSLNGNQLKDIG------TLASLTNLTDLDLANNQISNL 288
Cdd:cd00116  157 lakALRANRDLKELNLANNGIGDagIRALAeglkANCNLEVLDLNNNGLTDEGasalaeTLASLKSLEVLNLGDNNLTDA 236

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 403399437 289 -------APLSGLTKLTELKLGANQI------SNISPLAGLTALTNLELNENQL 329
Cdd:cd00116  237 gaaalasALLSPNISLLTLSLSCNDItddgakDLAEVLAEKESLLELDLRGNKF 290
List_Bact_rpt TIGR02543
Listeria/Bacterioides repeat; This model describes a conserved core region, about 43 residues ...
 595-637 8.61e-09

Listeria/Bacterioides repeat; This model describes a conserved core region, about 43 residues in length, of at least two families of tandem repeats. These include 78-residue repeats from 2 to 15 in number, in some proteins of Bacteroides forsythus ATCC 43037, and 70-residue repeats in families of internalins of Listeria species. Single copies are found in proteins of Fibrobacter succinogenes, Geobacter sulfurreducens, and a few bacteria. [Unknown function, General]


Pssm-ID: 274189 [Multi-domain]  Cd Length: 43  Bit Score: 51.86  E-value: 8.61e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 403399437  595 PTKEGYTFKGWYDAKTGGDKWDFATSKMPAKNITLYAQYSANS 637
Cdd:TIGR02543   1 PTKTGYTFVGWTGDSTGTPVKNFTIPSGSTGDLTLYAKWTPNT 43
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
135-352 1.02e-08

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 59.02  E-value: 1.02e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 135 ITPLANLTNLTGL-------TLFNNQITDIDPLKnlTNLNRLELSSNTISDISAL-SGLTSLqqLSFGNQVTDLKPLAnl 206
Cdd:PRK15387 228 VIPDNNLTSLPALppelrtlEVSGNQLTSLPVLP--PGLLELSIFSNPLTHLPALpSGLCKL--WIFGNQLTSLPVLP-- 301

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 207 TTLERLDISSNKVSDISVLAklTNLESLIATNNQISDITPLGilTNLDELSLNGNQLKDIGTLASltNLTDLDLANNQIS 286
Cdd:PRK15387 302 PGLQELSVSDNQLASLPALP--SELCKLWAYNNQLTSLPTLP--SGLQELSVSDNQLASLPTLPS--ELYKLWAYNNRLT 375

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 403399437 287 NLAPLSglTKLTELKLGANQISNISPLAglTALTNLELNENQLEDISPISNlkNLTYLTLYFNNIS 352
Cdd:PRK15387 376 SLPALP--SGLKELIVSGNRLTSLPVLP--SELKELMVSGNRLTSLPMLPS--GLLSLSVYRNQLT 435
LRR_8 pfam13855
Leucine rich repeat;
251-307 9.24e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.45  E-value: 9.24e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 403399437  251 TNLDELSLNGNQLKDI--GTLASLTNLTDLDLANNQISNLAP--LSGLTKLTELKLGANQI 307
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLddGAFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 142-184 1.92e-07

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 48.01  E-value: 1.92e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 403399437  142 TNLTGLTLFNNQITDIDPLKNLTNLNRLELSSNT-ISDISALSG 184
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNNkITDLSDLAN 44
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 251-293 2.73e-07

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 47.63  E-value: 2.73e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 403399437  251 TNLDELSLNGNQLKDIGTLASLTNLTDLDLA-NNQISNLAPLSG 293
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSgNNKITDLSDLAN 44
LRR_8 pfam13855
Leucine rich repeat;
273-329 6.01e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.13  E-value: 6.01e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 403399437  273 TNLTDLDLANNQISNLAP--LSGLTKLTELKLGANQISNISP--LAGLTALTNLELNENQL 329
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 207-247 7.28e-07

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 46.47  E-value: 7.28e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 403399437  207 TTLERLDISSNKVSDISVLAKLTNLESL-IATNNQISDITPL 247
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLdLSGNNKITDLSDL 42
LRR_8 pfam13855
Leucine rich repeat;
142-197 1.37e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.98  E-value: 1.37e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 403399437  142 TNLTGLTLFNNQITDIDP--LKNLTNLNRLELSSNTISDIS--ALSGLTSLQQLS-FGNQV 197
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLSpgAFSGLPSLRYLDlSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 99-140 1.39e-06

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 45.70  E-value: 1.39e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 403399437   99 NLTQINFSNNQLTDITPLKNLTKLVDI-LMNNNQIADITPLAN 140
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLdLSGNNKITDLSDLAN 44
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 273-315 2.00e-06

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 44.93  E-value: 2.00e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 403399437  273 TNLTDLDLANNQISNLAPLSGLTKLTELKLGAN-QISNISPLAG 315
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSDLAN 44
LRR_9 pfam14580
Leucine-rich repeat;
97-177 3.70e-06

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 47.84  E-value: 3.70e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437   97 LNNLTQINFSNNQLTDITPLKNLTKLVDILMNNNQIADITPLAN--LTNLTGLTLFNNQIT---DIDPLKNLTNLNRLEL 171
Cdd:pfam14580  41 LDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIGEGLGeaLPNLTELILTNNNLQelgDLDPLASLKKLTFLSL 120


                  ....*.
gi 403399437  172 SSNTIS 177
Cdd:pfam14580 121 LRNPVT 126
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 229-271 5.82e-06

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 43.77  E-value: 5.82e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 403399437  229 TNLESLIATNNQISDITPLGILTNLDELSLNGN-QLKDIGTLAS 271
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSDLAN 44
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 117-162 6.00e-06

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 43.77  E-value: 6.00e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 403399437  117 KNLTKLvdiLMNNNQIADITPLANLTNLTGLTL-FNNQITDIDPLKN 162
Cdd:pfam12799   1 PNLEVL---DLSNNQITDIPPLAKLPNLETLDLsGNNKITDLSDLAN 44
LRR_9 pfam14580
Leucine-rich repeat;
75-155 6.05e-06

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 47.45  E-value: 6.05e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437   75 LDQVTTLQADRLGIKSIDGVEYLNNLTQINFSNNQLTDITP-----LKNLTKLvdILMNNN--QIADITPLANLTNLTGL 147
Cdd:pfam14580  41 LDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIGEglgeaLPNLTEL--ILTNNNlqELGDLDPLASLKKLTFL 118


                  ....*...
gi 403399437  148 TLFNNQIT 155
Cdd:pfam14580 119 SLLRNPVT 126
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 317-359 9.15e-06

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 43.39  E-value: 9.15e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 403399437  317 TALTNLELNENQLEDISPISNLKNLTYLTLYFNN-ISDISPVSS 359
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNNkITDLSDLAN 44
LRR_9 pfam14580
Leucine-rich repeat;
255-352 9.34e-06

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 46.68  E-value: 9.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437  255 ELSLNGNQLKDIGTL-ASLTNLTDLDLANNQISNLAPLSGLTKLTELKLGANQISNISPLAG--LTALTNLELNEN---Q 328
Cdd:pfam14580  23 ELDLRGYKIPIIENLgATLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIGEGLGeaLPNLTELILTNNnlqE 102

                          90       100
                  ....*....|....*....|....
gi 403399437  329 LEDISPISNLKNLTYLTLYFNNIS 352
Cdd:pfam14580 103 LGDLDPLASLKKLTFLSLLRNPVT 126
LRR_8 pfam13855
Leucine rich repeat;
295-351 1.05e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.67  E-value: 1.05e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 403399437  295 TKLTELKLGANQISNISP--LAGLTALTNLELNENQLEDISP--ISNLKNLTYLTLYFNNI 351
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
229-285 2.29e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.51  E-value: 2.29e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 403399437  229 TNLESLIATNNQISDITP--LGILTNLDELSLNGNQLKDI--GTLASLTNLTDLDLANNQI 285
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLspGAFSGLPSLRYLDLSGNRL 61
LRR_9 pfam14580
Leucine-rich repeat;
204-287 2.58e-05

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 45.52  E-value: 2.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437  204 ANLTTLERLDISSNKVSDISVLAKLTNLESLIATNNQISDITP-LG-ILTNLDELSLNGNQLKDIGT---LASLTNLTDL 278
Cdd:pfam14580  39 ATLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIGEgLGeALPNLTELILTNNNLQELGDldpLASLKKLTFL 118


                  ....*....
gi 403399437  279 DLANNQISN 287
Cdd:pfam14580 119 SLLRNPVTN 127
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 339-381 4.54e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 41.46  E-value: 4.54e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 403399437  339 KNLTYLTLYFNNISDISPVSSLTKLQRLFFY-NNKVSDVSSLAN 381
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSgNNKITDLSDLAN 44
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 99-256 4.86e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 46.71  E-value: 4.86e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437  99 NLTQINFSNNQLTD------ITPLKNLTKLVDILMNNNQIAD------ITPLANLTNLTGLTLFNNQITD------IDPL 160
Cdd:COG5238  265 TVETLYLSGNQIGAegaialAKALQGNTTLTSLDLSVNRIGDegaialAEGLQGNKTLHTLNLAYNGIGAqgaialAKAL 344

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 161 KNLTNLNRLELSSNTISDISALSGLTSLQqlsfgnqvtdlkplaNLTTLERLDISSNKVSDISVLA-----KLTNLESLI 235
Cdd:COG5238  345 QENTTLHSLDLSDNQIGDEGAIALAKYLE---------------GNTTLRELNLGKNNIGKQGAEAlidalQTNRLHTLI 409

                        170       180
                 ....*....|....*....|.
gi 403399437 236 ATNNQISDITPLGILTNLDEL 256
Cdd:COG5238  410 LDGNLIGAEAQQRLEQLLERI 430
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 90-267 1.20e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 45.04  E-value: 1.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437  90 SIDGVEYLNNLTQINF------SNNQLTD-ITPLK---------NLTKLVdiLMNNN-QIADITPLANL----TNLTGLT 148
Cdd:cd00116   94 GPDGCGVLESLLRSSSlqelklNNNGLGDrGLRLLakglkdlppALEKLV--LGRNRlEGASCEALAKAlranRDLKELN 171

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 149 LFNNQITD------IDPLKNLTNLNRLELSSNTISD--ISALSGLtslqqlsfgnqvtdlkpLANLTTLERLDISSNKVS 220
Cdd:cd00116  172 LANNGIGDagiralAEGLKANCNLEVLDLNNNGLTDegASALAET-----------------LASLKSLEVLNLGDNNLT 234

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437 221 D--ISVLAK-----LTNLESLIATNNQISD------ITPLGILTNLDELSLNGNQLKDIG 267
Cdd:cd00116  235 DagAAALASallspNISLLTLSLSCNDITDdgakdlAEVLAEKESLLELDLRGNKFGEEG 294
LRR_9 pfam14580
Leucine-rich repeat;
212-309 1.47e-04

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 43.21  E-value: 1.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437  212 LDISSNKVSDISVL-AKLTNLESLIATNNQISDITPLGILTNLDELSLNGNQLKDI--GTLASLTNLTDLDLANNQISNL 288
Cdd:pfam14580  24 LDLRGYKIPIIENLgATLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIgeGLGEALPNLTELILTNNNLQEL 103

                          90       100
                  ....*....|....*....|....
gi 403399437  289 A---PLSGLTKLTELKLGANQISN 309
Cdd:pfam14580 104 GdldPLASLKKLTFLSLLRNPVTN 127
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 164-205 1.58e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.92  E-value: 1.58e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 403399437  164 TNLNRLELSSNTISDISALSGLTSLQQL--SFGNQVTDLKPLAN 205
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLdlSGNNKITDLSDLAN 44
LRR_8 pfam13855
Leucine rich repeat;
340-395 1.77e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.20  E-value: 1.77e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437  340 NLTYLTLYFNNISDISPVS--SLTKLQRLFFYNNKVSDVS--SLANLTNINWLSAGHNQI 395
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAfkGLSNLKVLDLSNNLLTTLSpgAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
319-373 1.80e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.20  E-value: 1.80e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 403399437  319 LTNLELNENQLEDISPIS--NLKNLTYLTLYFNNISDISPVS--SLTKLQRLFFYNNKV 373
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAfkGLSNLKVLDLSNNLLTTLSPGAfsGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
207-263 5.11e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.66  E-value: 5.11e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 403399437  207 TTLERLDISSNKVSDI--SVLAKLTNLESLIATNNQISDITPLGI--LTNLDELSLNGNQL 263
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLddGAFKGLSNLKVLDLSNNLLTTLSPGAFsgLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 186-227 1.12e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 37.22  E-value: 1.12e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 403399437  186 TSLQQLSF-GNQVTDLKPLANLTTLERLDISSN-KVSDISVLAK 227
Cdd:pfam12799   1 PNLEVLDLsNNQITDIPPLAKLPNLETLDLSGNnKITDLSDLAN 44
LRR_8 pfam13855
Leucine rich repeat;
164-241 2.24e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.12  E-value: 2.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437  164 TNLNRLELSSNtisdisalsGLTSLQQLSFgnqvtdlkplANLTTLERLDISSNKVSDIS--VLAKLTNLESLIATNNQI 241
Cdd:pfam13855   1 PNLRSLDLSNN---------RLTSLDDGAF----------KGLSNLKVLDLSNNLLTTLSpgAFSGLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 361-403 2.78e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.07  E-value: 2.78e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 403399437  361 TKLQRLFFYNNKVSDVSSLANLTNIN--WLSaGHNQISDLTPLAN 403
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLEtlDLS-GNNKITDLSDLAN 44
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 250-389 2.85e-03

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 41.40  E-value: 2.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437  250 LTNLDELSLNGNQ-LKDIGTLASLTNLTDLDLANnqISNLAPLSG----LTKLTELKL-----------GANQIS----N 309
Cdd:PLN03210  633 LTGLRNIDLRGSKnLKEIPDLSMATNLETLKLSD--CSSLVELPSsiqyLNKLEDLDMsrcenleilptGINLKSlyrlN 710

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403399437  310 ISPLAGL-------TALTNLELNENQLEDISPISNLKNLTYLTLY-------FNNISDISPVSSLT--KLQRLFFYNNK- 372
Cdd:PLN03210  711 LSGCSRLksfpdisTNISWLDLDETAIEEFPSNLRLENLDELILCemkseklWERVQPLTPLMTMLspSLTRLFLSDIPs 790

                         170
                  ....*....|....*...
gi 403399437  373 -VSDVSSLANLTNINWLS 389
Cdd:PLN03210  791 lVELPSSIQNLHKLEHLE 808
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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