NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|123963|sp|P01085|]
View 

RecName: Full=Alpha-amylase inhibitor 0.19; AltName: Full=0.19 alpha-AI; Short=0.19 AI; AltName: Allergen=Tri a 28

Protein Classification

alpha-amylase inhibitor/seed storage family protein( domain architecture ID 10083580)

alpha-amylase inhibitors (AAIs) and seed storage (SS) proteins play an important role in the natural defenses of plants against insects and pathogens such as fungi, bacteria and viruses; AAIs impede the digestion of plant starch and proteins by inhibiting digestive alpha-amylases and proteinases.

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
AAI_SS cd00261
AAI_SS: Alpha-Amylase Inhibitors (AAIs) and Seed Storage (SS) Protein subfamily; composed of ...
 3-103 5.38e-22

AAI_SS: Alpha-Amylase Inhibitors (AAIs) and Seed Storage (SS) Protein subfamily; composed of cereal-type AAIs and SS proteins. They are mainly present in the seeds of a variety of plants. AAIs play an important role in the natural defenses of plants against insects and pathogens such as fungi, bacteria and viruses. AAIs impede the digestion of plant starch and proteins by inhibiting digestive alpha-amylases and proteinases. Also included in this subfamily are SS proteins such as 2S albumin, gamma-gliadin, napin, and prolamin. These AAIs and SS proteins are also known allergens in humans.


:

Pssm-ID: 238163  Cd Length: 110  Bit Score: 83.61  E-value: 5.38e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123963     3 PWMCYPGQAFQVPALPACRPLLRLQCNG--------SQVPEAVLRDCCQQLAHISEWCRCGALYSMLDSMYkehgaQEGQ 74
Cdd:cd00261   1 QQQCQPGQQQPQQPLNSCREYLRQQCSGvggppvwpQQSCEVLRQQCCQQLAQIPEQCRCEALRQMVQGVI-----QQQQ 75

                        90       100
                ....*....|....*....|....*....
gi 123963    75 AGTGAFPRCRREVVKLTAASITAVCRLPI 103
Cdd:cd00261  76 QQQEQQQGQEVERMRQAAQNLPSMCNLYP 104
 
Name Accession Description Interval E-value
AAI_SS cd00261
AAI_SS: Alpha-Amylase Inhibitors (AAIs) and Seed Storage (SS) Protein subfamily; composed of ...
 3-103 5.38e-22

AAI_SS: Alpha-Amylase Inhibitors (AAIs) and Seed Storage (SS) Protein subfamily; composed of cereal-type AAIs and SS proteins. They are mainly present in the seeds of a variety of plants. AAIs play an important role in the natural defenses of plants against insects and pathogens such as fungi, bacteria and viruses. AAIs impede the digestion of plant starch and proteins by inhibiting digestive alpha-amylases and proteinases. Also included in this subfamily are SS proteins such as 2S albumin, gamma-gliadin, napin, and prolamin. These AAIs and SS proteins are also known allergens in humans.


Pssm-ID: 238163  Cd Length: 110  Bit Score: 83.61  E-value: 5.38e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123963     3 PWMCYPGQAFQVPALPACRPLLRLQCNG--------SQVPEAVLRDCCQQLAHISEWCRCGALYSMLDSMYkehgaQEGQ 74
Cdd:cd00261   1 QQQCQPGQQQPQQPLNSCREYLRQQCSGvggppvwpQQSCEVLRQQCCQQLAQIPEQCRCEALRQMVQGVI-----QQQQ 75

                        90       100
                ....*....|....*....|....*....
gi 123963    75 AGTGAFPRCRREVVKLTAASITAVCRLPI 103
Cdd:cd00261  76 QQQEQQQGQEVERMRQAAQNLPSMCNLYP 104
Tryp_alpha_amyl pfam00234
Protease inhibitor/seed storage/LTP family; This family is composed of trypsin-alpha amylase ...
 13-104 3.28e-04

Protease inhibitor/seed storage/LTP family; This family is composed of trypsin-alpha amylase inhibitors, seed storage proteins and lipid transfer proteins from plants.


Pssm-ID: 425543  Cd Length: 74  Bit Score: 36.78  E-value: 3.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123963      13 QVPALPACRPLLRLQCNgsqvpeAVLRDCCQQLAHISEWCRCGALYSMLDSMykehgaqegqagtgafprcrREVVKLTA 92
Cdd:pfam00234   4 VLLCLAPCLGYLQGGCQ------VPSQQCCSQLRQLQAQCRCTAIRAIVLGI--------------------EGINPQAA 57

                          90
                  ....*....|..
gi 123963      93 ASITAVCRLPIV 104
Cdd:pfam00234  58 ASLPSMCGVNVP 69
 
Name Accession Description Interval E-value
AAI_SS cd00261
AAI_SS: Alpha-Amylase Inhibitors (AAIs) and Seed Storage (SS) Protein subfamily; composed of ...
 3-103 5.38e-22

AAI_SS: Alpha-Amylase Inhibitors (AAIs) and Seed Storage (SS) Protein subfamily; composed of cereal-type AAIs and SS proteins. They are mainly present in the seeds of a variety of plants. AAIs play an important role in the natural defenses of plants against insects and pathogens such as fungi, bacteria and viruses. AAIs impede the digestion of plant starch and proteins by inhibiting digestive alpha-amylases and proteinases. Also included in this subfamily are SS proteins such as 2S albumin, gamma-gliadin, napin, and prolamin. These AAIs and SS proteins are also known allergens in humans.


Pssm-ID: 238163  Cd Length: 110  Bit Score: 83.61  E-value: 5.38e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123963     3 PWMCYPGQAFQVPALPACRPLLRLQCNG--------SQVPEAVLRDCCQQLAHISEWCRCGALYSMLDSMYkehgaQEGQ 74
Cdd:cd00261   1 QQQCQPGQQQPQQPLNSCREYLRQQCSGvggppvwpQQSCEVLRQQCCQQLAQIPEQCRCEALRQMVQGVI-----QQQQ 75

                        90       100
                ....*....|....*....|....*....
gi 123963    75 AGTGAFPRCRREVVKLTAASITAVCRLPI 103
Cdd:cd00261  76 QQQEQQQGQEVERMRQAAQNLPSMCNLYP 104
Tryp_alpha_amyl pfam00234
Protease inhibitor/seed storage/LTP family; This family is composed of trypsin-alpha amylase ...
 13-104 3.28e-04

Protease inhibitor/seed storage/LTP family; This family is composed of trypsin-alpha amylase inhibitors, seed storage proteins and lipid transfer proteins from plants.


Pssm-ID: 425543  Cd Length: 74  Bit Score: 36.78  E-value: 3.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123963      13 QVPALPACRPLLRLQCNgsqvpeAVLRDCCQQLAHISEWCRCGALYSMLDSMykehgaqegqagtgafprcrREVVKLTA 92
Cdd:pfam00234   4 VLLCLAPCLGYLQGGCQ------VPSQQCCSQLRQLQAQCRCTAIRAIVLGI--------------------EGINPQAA 57

                          90
                  ....*....|..
gi 123963      93 ASITAVCRLPIV 104
Cdd:pfam00234  58 ASLPSMCGVNVP 69
Gliadin pfam13016
Cys-rich Gliadin N-terminal; This is a cysteine-rich N-terminal region of gliadin and avenin ...
 15-64 2.05e-03

Cys-rich Gliadin N-terminal; This is a cysteine-rich N-terminal region of gliadin and avenin plant proteins. The exact function is not known.


Pssm-ID: 404039  Cd Length: 75  Bit Score: 34.53  E-value: 2.05e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 123963      15 PALPACRPLLRLQCNGSQVP------------EAVLRDCCQQLAHISEWCRCGALYSMLDSM 64
Cdd:pfam13016  13 QQLNPCKEFLQQQCSPVTVPflqsrtlqqsncQVMQQQCCQQLRQIPEQSRCQAIHNIVQAI 74
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH