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Conserved domains on  [gi|1230098642|gb|OYF88448|]
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glucose-6-phosphate dehydrogenase [Klebsiella quasipneumoniae subsp. similipneumoniae]

Protein Classification

glucose-6-phosphate dehydrogenase( domain architecture ID 11417513)

glucose-6-phosphate dehydrogenase (NADP(+)) catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone

CATH:  3.40.50.720
EC:  1.1.1.49
Gene Ontology:  GO:0004345|GO:0050661|GO:0006006
PubMed:  39259139|24720642
SCOP:  4000091

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Zwf COG0364
Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; ...
 1-489 0e+00

Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; Glucose-6-phosphate 1-dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


:

Pssm-ID: 440133 [Multi-domain]  Cd Length: 495  Bit Score: 869.01  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642   1 MAVTQTAQACDLVIFGAKGDLARRKLLPSLYQLEKAGQIHADTRIIGVGRADWDKAAYTKVVREALETFMKEKIDEGLWD 80
Cdd:COG0364     1 MTQMRPAEPCDLVIFGATGDLARRKLLPALYNLYRDGLLPEGFRIIGVARRDWSDEEFREEVREALEEFSRKPFDEEVWE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642  81 SLSGRLEFCNLDVNDTSGFTRLGDMLDQ-----KNRVTINYFAMPPSTFGAICKGLGEAKLNAKPA--RVVMEKPLGTSL 153
Cdd:COG0364    81 RFLERLHYVSGDFTDPEGYERLKELLEEldeerTPGNRVFYLATPPSLFGPICENLGAAGLATEGGwrRVVIEKPFGHDL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642 154 ETSREINDQVGEFFEECQVYRIDHYLGKETVLNLLALRFANSLFVNNWDCRTIDHVEITVAEEVGIEGRWGYFDQAGQMR 233
Cdd:COG0364   161 ASARELNDELGRVFDESQIYRIDHYLGKETVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDGAGALR 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642 234 DMIQNHLLQILCMIAMSPPSDLSADSIRDEKVKVLKSLRRIDRSNVREKTVRGQYTAGFAQGKKVPGYLEEEGANKTSNT 313
Cdd:COG0364   241 DMVQNHLLQLLCLVAMEPPASLDADAIRDEKVKVLRALRPITPEDVAENTVRGQYTAGWIGGEPVPGYREEPGVAPDSTT 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642 314 ETFVAIRVDIDNWRWAGVPFYLRTGKRLPTKCSEVVVYFKTPELNLFKETWQELPQNKLTIRLQPDEGVDIQVLNKVPGL 393
Cdd:COG0364   321 ETFVALKLEIDNWRWAGVPFYLRTGKRLPERVTEIVIQFKPVPHSLFRETAEELPPNRLVIRIQPDEGISLRFNAKVPGL 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642 394 DHKhnLQITKLDLSYSETFNQtHLADAYERLLLETMRGIQALFVRRDEVEEAWKWVDSITEAWAADRDAPKPYQAGTWGP 473
Cdd:COG0364   401 GMR--LRPVSLDFSYSDAFGE-RSPEAYERLLLDVMRGDQTLFMRRDEVEAAWRWVDPILEAWAEEPEPPPPYPAGSWGP 477

                         490
                  ....*....|....*.
gi 1230098642 474 VASVAMITRDGRSWNE 489
Cdd:COG0364   478 EAADALLARDGRSWRE 493
 
Name Accession Description Interval E-value
Zwf COG0364
Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; ...
 1-489 0e+00

Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; Glucose-6-phosphate 1-dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440133 [Multi-domain]  Cd Length: 495  Bit Score: 869.01  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642   1 MAVTQTAQACDLVIFGAKGDLARRKLLPSLYQLEKAGQIHADTRIIGVGRADWDKAAYTKVVREALETFMKEKIDEGLWD 80
Cdd:COG0364     1 MTQMRPAEPCDLVIFGATGDLARRKLLPALYNLYRDGLLPEGFRIIGVARRDWSDEEFREEVREALEEFSRKPFDEEVWE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642  81 SLSGRLEFCNLDVNDTSGFTRLGDMLDQ-----KNRVTINYFAMPPSTFGAICKGLGEAKLNAKPA--RVVMEKPLGTSL 153
Cdd:COG0364    81 RFLERLHYVSGDFTDPEGYERLKELLEEldeerTPGNRVFYLATPPSLFGPICENLGAAGLATEGGwrRVVIEKPFGHDL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642 154 ETSREINDQVGEFFEECQVYRIDHYLGKETVLNLLALRFANSLFVNNWDCRTIDHVEITVAEEVGIEGRWGYFDQAGQMR 233
Cdd:COG0364   161 ASARELNDELGRVFDESQIYRIDHYLGKETVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDGAGALR 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642 234 DMIQNHLLQILCMIAMSPPSDLSADSIRDEKVKVLKSLRRIDRSNVREKTVRGQYTAGFAQGKKVPGYLEEEGANKTSNT 313
Cdd:COG0364   241 DMVQNHLLQLLCLVAMEPPASLDADAIRDEKVKVLRALRPITPEDVAENTVRGQYTAGWIGGEPVPGYREEPGVAPDSTT 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642 314 ETFVAIRVDIDNWRWAGVPFYLRTGKRLPTKCSEVVVYFKTPELNLFKETWQELPQNKLTIRLQPDEGVDIQVLNKVPGL 393
Cdd:COG0364   321 ETFVALKLEIDNWRWAGVPFYLRTGKRLPERVTEIVIQFKPVPHSLFRETAEELPPNRLVIRIQPDEGISLRFNAKVPGL 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642 394 DHKhnLQITKLDLSYSETFNQtHLADAYERLLLETMRGIQALFVRRDEVEEAWKWVDSITEAWAADRDAPKPYQAGTWGP 473
Cdd:COG0364   401 GMR--LRPVSLDFSYSDAFGE-RSPEAYERLLLDVMRGDQTLFMRRDEVEAAWRWVDPILEAWAEEPEPPPPYPAGSWGP 477

                         490
                  ....*....|....*.
gi 1230098642 474 VASVAMITRDGRSWNE 489
Cdd:COG0364   478 EAADALLARDGRSWRE 493
PRK05722 PRK05722
glucose-6-phosphate 1-dehydrogenase; Validated
 1-489 0e+00

glucose-6-phosphate 1-dehydrogenase; Validated


Pssm-ID: 235579 [Multi-domain]  Cd Length: 495  Bit Score: 855.58  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642   1 MAVTQTAQACDLVIFGAKGDLARRKLLPSLYQLEKAGQIHADTRIIGVGRADWDKAAYTKVVREALETFMKEKIDEGLWD 80
Cdd:PRK05722    1 MRLPRTAEPCDLVIFGATGDLARRKLLPALYNLYKAGLLPEDFRIIGVARRDWSDEDFREVVREALKEFARTPFDEEVWE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642  81 SLSGRLEFCNLDVNDTSGFTRLGDMLD------QKNRVTINYFAMPPSTFGAICKGLGEAKLNA--KPARVVMEKPLGTS 152
Cdd:PRK05722   81 RFLSRLYYVSGDVTDPESYERLKELLEeldeerGTGGNRVFYLATPPSLFGTICENLAAAGLNEggGWRRVVIEKPFGHD 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642 153 LETSREINDQVGEFFEECQVYRIDHYLGKETVLNLLALRFANSLFVNNWDCRTIDHVEITVAEEVGIEGRWGYFDQAGQM 232
Cdd:PRK05722  161 LASARELNDQVGEVFKEEQIYRIDHYLGKETVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDKSGAL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642 233 RDMIQNHLLQILCMIAMSPPSDLSADSIRDEKVKVLKSLRRIDRSNVREKTVRGQYTAGFAQGKKVPGYLEEEGANKTSN 312
Cdd:PRK05722  241 RDMVQNHLLQLLALVAMEPPASLDADSIRDEKVKVLRALRPITPEDVKENTVRGQYTAGWIGGKPVPGYREEEGVNPDST 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642 313 TETFVAIRVDIDNWRWAGVPFYLRTGKRLPTKCSEVVVYFKTPELNLFKETWQELPQNKLTIRLQPDEGVDIQVLNKVPG 392
Cdd:PRK05722  321 TETFVALKLEIDNWRWAGVPFYLRTGKRLPKKVTEIVIVFKPPPHNLFEESAEELGPNKLVIRIQPDEGISLRFNAKVPG 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642 393 LDHKhnLQITKLDLSYSETFNQThLADAYERLLLETMRGIQALFVRRDEVEEAWKWVDSITEAWAADRDAPKPYQAGTWG 472
Cdd:PRK05722  401 EGME--LRPVKLDFSYSEAFGEA-SPEAYERLLLDVMLGDQTLFVRRDEVEAAWKWVDPILEAWEADGGPPPPYPAGTWG 477

                         490
                  ....*....|....*..
gi 1230098642 473 PVASVAMITRDGRSWNE 489
Cdd:PRK05722  478 PEAADALLARDGRSWRE 494
zwf TIGR00871
glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and ...
 8-490 0e+00

glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and reduces NADP(+). An alternate name appearing in the literature for the human enzyme, based on a slower activity with beta-D-glucose, is glucose 1-dehydrogenase (EC 1.1.1.47), but that name more properly describes a subfamily of the short chain dehydrogenases/reductases family. This is a well-studied enzyme family, with sequences available from well over 50 species. The trusted cutoff is set above the score for the Drosophila melanogaster CG7140 gene product, a homolog of unknown function. G6PD homologs from the bacteria Aquifex aeolicus and Helicobacter pylori lack several motifs well conserved most other members, were omitted from the seed alignment, and score well below the trusted cutoff. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273312 [Multi-domain]  Cd Length: 487  Bit Score: 754.93  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642   8 QACDLVIFGAKGDLARRKLLPSLYQLEKAGQIHADTRIIGVGRADWDKAAYTKVVREALETFMKEKIDEGlWDSLSGRLE 87
Cdd:TIGR00871   1 DPCILVIFGASGDLARKKLFPALYRLFRNGLLPPDFRIVGVARRDWSVEEFRKVVREAIIKFETDEIDEQ-WDEFAQRLS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642  88 FCNLDVNDTSGFTRLGDMLDQKNRV------TINYFAMPPSTFGAICKGLGEAKLNAKP--ARVVMEKPLGTSLETSREI 159
Cdd:TIGR00871  80 YVSGDVDDDESYDSLAELLEQLDKTygtegnRLFYLATPPSLFGTIIKQLKKHGLNEQGkwSRVVVEKPFGHDLASAQEL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642 160 NDQVGEFFEECQVYRIDHYLGKETVLNLLALRFANSLFVNNWDCRTIDHVEITVAEEVGIEGRWGYFDQAGQMRDMIQNH 239
Cdd:TIGR00871 160 NKALRAVFKEDQIYRIDHYLGKETVQNLLVLRFANQIFEPLWNRRYIDHVQITVAESFGVEGRGGYYDKSGALRDMVQNH 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642 240 LLQILCMIAMSPPSDLSADSIRDEKVKVLKSLRRIDRSNvrEKTVRGQYTAGFAQGKKVPGYLEEEGANKTSNTETFVAI 319
Cdd:TIGR00871 240 LLQLLALVAMEPPVSFDADSIRDEKVKVLKALRPIDPDD--NNTVRGQYGAGEIGGVSVPGYLEEEGVDKDSNTETFAAL 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642 320 RVDIDNWRWAGVPFYLRTGKRLPTKCSEVVVYFKTPELNLFKETWQ-ELPQNKLTIRLQPDEGVDIQVLNKVPGLDhkHN 398
Cdd:TIGR00871 318 KLEIDNWRWAGVPFYLRTGKRLPEKVTEIRIQFRDVPSLLFKANERdANPRNALVIRIQPDEGVYLKFNAKKPGLN--FE 395

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642 399 LQITKLDLSYSETFnQTHLADAYERLLLETMRGIQALFVRRDEVEEAWKWVDSITEAWAADRDA-PKPYQAGTWGPVASV 477
Cdd:TIGR00871 396 TRPVKLDFSYASRF-GELLPEAYERLLLDALLGDHTLFARDDEVEEAWRIVTPILEAWAANKGPsPPNYPAGSWGPKEAD 474

                         490
                  ....*....|...
gi 1230098642 478 AMITRDGRSWNEF 490
Cdd:TIGR00871 475 ELIRKDGRSWRKP 487
G6PD_C pfam02781
Glucose-6-phosphate dehydrogenase, C-terminal domain;
188-487 3.66e-180

Glucose-6-phosphate dehydrogenase, C-terminal domain;


Pssm-ID: 460694  Cd Length: 295  Bit Score: 506.21  E-value: 3.66e-180
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642 188 LALRFANSLFVNNWDCRTIDHVEITVAEEVGIEGRWGYFDQAGQMRDMIQNHLLQILCMIAMSPPSDLSADSIRDEKVKV 267
Cdd:pfam02781   1 LVLRFANAIFEPLWNRNYIDHVQITVAETLGVEGRGGYYDQAGALRDMVQNHLLQLLALVAMEPPVSFDAEDIRDEKVKV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642 268 LKSLRRIDRSNVREKTVRGQYTAGFAQGKKVPGYLEEEGANKTSNTETFVAIRVDIDNWRWAGVPFYLRTGKRLPTKCSE 347
Cdd:pfam02781  81 LRSLRPITPEDVEDNVVRGQYGAGWIGGEPVPGYREEEGVPPDSRTETFAALKLFIDNWRWAGVPFYLRTGKRLPERVTE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642 348 VVVYFKTPELNLFKETwQELPQNKLTIRLQPDEGVDIQVLNKVPGLDHKhnLQITKLDLSYSETFNqTHLADAYERLLLE 427
Cdd:pfam02781 161 IRIQFKDVPHNLFRDP-GTLPPNELVIRIQPDEGIYLKFNAKVPGLGMR--LRPVELDFSYSDRFG-ERIPEAYERLLLD 236

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642 428 TMRGIQALFVRRDEVEEAWKWVDSITEAWAADRdaPKPYQAGTWGPVASVAMITRDGRSW 487
Cdd:pfam02781 237 VMRGDQTLFVRSDEVEAAWRIVDPILEAWDEEK--PPPYPAGSWGPKAADELLARDGRKW 294
 
Name Accession Description Interval E-value
Zwf COG0364
Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; ...
 1-489 0e+00

Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; Glucose-6-phosphate 1-dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440133 [Multi-domain]  Cd Length: 495  Bit Score: 869.01  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642   1 MAVTQTAQACDLVIFGAKGDLARRKLLPSLYQLEKAGQIHADTRIIGVGRADWDKAAYTKVVREALETFMKEKIDEGLWD 80
Cdd:COG0364     1 MTQMRPAEPCDLVIFGATGDLARRKLLPALYNLYRDGLLPEGFRIIGVARRDWSDEEFREEVREALEEFSRKPFDEEVWE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642  81 SLSGRLEFCNLDVNDTSGFTRLGDMLDQ-----KNRVTINYFAMPPSTFGAICKGLGEAKLNAKPA--RVVMEKPLGTSL 153
Cdd:COG0364    81 RFLERLHYVSGDFTDPEGYERLKELLEEldeerTPGNRVFYLATPPSLFGPICENLGAAGLATEGGwrRVVIEKPFGHDL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642 154 ETSREINDQVGEFFEECQVYRIDHYLGKETVLNLLALRFANSLFVNNWDCRTIDHVEITVAEEVGIEGRWGYFDQAGQMR 233
Cdd:COG0364   161 ASARELNDELGRVFDESQIYRIDHYLGKETVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDGAGALR 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642 234 DMIQNHLLQILCMIAMSPPSDLSADSIRDEKVKVLKSLRRIDRSNVREKTVRGQYTAGFAQGKKVPGYLEEEGANKTSNT 313
Cdd:COG0364   241 DMVQNHLLQLLCLVAMEPPASLDADAIRDEKVKVLRALRPITPEDVAENTVRGQYTAGWIGGEPVPGYREEPGVAPDSTT 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642 314 ETFVAIRVDIDNWRWAGVPFYLRTGKRLPTKCSEVVVYFKTPELNLFKETWQELPQNKLTIRLQPDEGVDIQVLNKVPGL 393
Cdd:COG0364   321 ETFVALKLEIDNWRWAGVPFYLRTGKRLPERVTEIVIQFKPVPHSLFRETAEELPPNRLVIRIQPDEGISLRFNAKVPGL 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642 394 DHKhnLQITKLDLSYSETFNQtHLADAYERLLLETMRGIQALFVRRDEVEEAWKWVDSITEAWAADRDAPKPYQAGTWGP 473
Cdd:COG0364   401 GMR--LRPVSLDFSYSDAFGE-RSPEAYERLLLDVMRGDQTLFMRRDEVEAAWRWVDPILEAWAEEPEPPPPYPAGSWGP 477

                         490
                  ....*....|....*.
gi 1230098642 474 VASVAMITRDGRSWNE 489
Cdd:COG0364   478 EAADALLARDGRSWRE 493
PRK05722 PRK05722
glucose-6-phosphate 1-dehydrogenase; Validated
 1-489 0e+00

glucose-6-phosphate 1-dehydrogenase; Validated


Pssm-ID: 235579 [Multi-domain]  Cd Length: 495  Bit Score: 855.58  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642   1 MAVTQTAQACDLVIFGAKGDLARRKLLPSLYQLEKAGQIHADTRIIGVGRADWDKAAYTKVVREALETFMKEKIDEGLWD 80
Cdd:PRK05722    1 MRLPRTAEPCDLVIFGATGDLARRKLLPALYNLYKAGLLPEDFRIIGVARRDWSDEDFREVVREALKEFARTPFDEEVWE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642  81 SLSGRLEFCNLDVNDTSGFTRLGDMLD------QKNRVTINYFAMPPSTFGAICKGLGEAKLNA--KPARVVMEKPLGTS 152
Cdd:PRK05722   81 RFLSRLYYVSGDVTDPESYERLKELLEeldeerGTGGNRVFYLATPPSLFGTICENLAAAGLNEggGWRRVVIEKPFGHD 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642 153 LETSREINDQVGEFFEECQVYRIDHYLGKETVLNLLALRFANSLFVNNWDCRTIDHVEITVAEEVGIEGRWGYFDQAGQM 232
Cdd:PRK05722  161 LASARELNDQVGEVFKEEQIYRIDHYLGKETVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDKSGAL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642 233 RDMIQNHLLQILCMIAMSPPSDLSADSIRDEKVKVLKSLRRIDRSNVREKTVRGQYTAGFAQGKKVPGYLEEEGANKTSN 312
Cdd:PRK05722  241 RDMVQNHLLQLLALVAMEPPASLDADSIRDEKVKVLRALRPITPEDVKENTVRGQYTAGWIGGKPVPGYREEEGVNPDST 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642 313 TETFVAIRVDIDNWRWAGVPFYLRTGKRLPTKCSEVVVYFKTPELNLFKETWQELPQNKLTIRLQPDEGVDIQVLNKVPG 392
Cdd:PRK05722  321 TETFVALKLEIDNWRWAGVPFYLRTGKRLPKKVTEIVIVFKPPPHNLFEESAEELGPNKLVIRIQPDEGISLRFNAKVPG 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642 393 LDHKhnLQITKLDLSYSETFNQThLADAYERLLLETMRGIQALFVRRDEVEEAWKWVDSITEAWAADRDAPKPYQAGTWG 472
Cdd:PRK05722  401 EGME--LRPVKLDFSYSEAFGEA-SPEAYERLLLDVMLGDQTLFVRRDEVEAAWKWVDPILEAWEADGGPPPPYPAGTWG 477

                         490
                  ....*....|....*..
gi 1230098642 473 PVASVAMITRDGRSWNE 489
Cdd:PRK05722  478 PEAADALLARDGRSWRE 494
zwf TIGR00871
glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and ...
 8-490 0e+00

glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and reduces NADP(+). An alternate name appearing in the literature for the human enzyme, based on a slower activity with beta-D-glucose, is glucose 1-dehydrogenase (EC 1.1.1.47), but that name more properly describes a subfamily of the short chain dehydrogenases/reductases family. This is a well-studied enzyme family, with sequences available from well over 50 species. The trusted cutoff is set above the score for the Drosophila melanogaster CG7140 gene product, a homolog of unknown function. G6PD homologs from the bacteria Aquifex aeolicus and Helicobacter pylori lack several motifs well conserved most other members, were omitted from the seed alignment, and score well below the trusted cutoff. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273312 [Multi-domain]  Cd Length: 487  Bit Score: 754.93  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642   8 QACDLVIFGAKGDLARRKLLPSLYQLEKAGQIHADTRIIGVGRADWDKAAYTKVVREALETFMKEKIDEGlWDSLSGRLE 87
Cdd:TIGR00871   1 DPCILVIFGASGDLARKKLFPALYRLFRNGLLPPDFRIVGVARRDWSVEEFRKVVREAIIKFETDEIDEQ-WDEFAQRLS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642  88 FCNLDVNDTSGFTRLGDMLDQKNRV------TINYFAMPPSTFGAICKGLGEAKLNAKP--ARVVMEKPLGTSLETSREI 159
Cdd:TIGR00871  80 YVSGDVDDDESYDSLAELLEQLDKTygtegnRLFYLATPPSLFGTIIKQLKKHGLNEQGkwSRVVVEKPFGHDLASAQEL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642 160 NDQVGEFFEECQVYRIDHYLGKETVLNLLALRFANSLFVNNWDCRTIDHVEITVAEEVGIEGRWGYFDQAGQMRDMIQNH 239
Cdd:TIGR00871 160 NKALRAVFKEDQIYRIDHYLGKETVQNLLVLRFANQIFEPLWNRRYIDHVQITVAESFGVEGRGGYYDKSGALRDMVQNH 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642 240 LLQILCMIAMSPPSDLSADSIRDEKVKVLKSLRRIDRSNvrEKTVRGQYTAGFAQGKKVPGYLEEEGANKTSNTETFVAI 319
Cdd:TIGR00871 240 LLQLLALVAMEPPVSFDADSIRDEKVKVLKALRPIDPDD--NNTVRGQYGAGEIGGVSVPGYLEEEGVDKDSNTETFAAL 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642 320 RVDIDNWRWAGVPFYLRTGKRLPTKCSEVVVYFKTPELNLFKETWQ-ELPQNKLTIRLQPDEGVDIQVLNKVPGLDhkHN 398
Cdd:TIGR00871 318 KLEIDNWRWAGVPFYLRTGKRLPEKVTEIRIQFRDVPSLLFKANERdANPRNALVIRIQPDEGVYLKFNAKKPGLN--FE 395

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642 399 LQITKLDLSYSETFnQTHLADAYERLLLETMRGIQALFVRRDEVEEAWKWVDSITEAWAADRDA-PKPYQAGTWGPVASV 477
Cdd:TIGR00871 396 TRPVKLDFSYASRF-GELLPEAYERLLLDALLGDHTLFARDDEVEEAWRIVTPILEAWAANKGPsPPNYPAGSWGPKEAD 474

                         490
                  ....*....|...
gi 1230098642 478 AMITRDGRSWNEF 490
Cdd:TIGR00871 475 ELIRKDGRSWRKP 487
PRK12853 PRK12853
glucose-6-phosphate dehydrogenase;
2-487 0e+00

glucose-6-phosphate dehydrogenase;


Pssm-ID: 237233 [Multi-domain]  Cd Length: 482  Bit Score: 648.50  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642   2 AVTQTAQACDLVIFGAKGDLARRKLLPSLYQLEKAGQIHADTRIIGVGRADWDKAAYTKVVREALETFMKEKIDEGLWDS 81
Cdd:PRK12853    1 ADTAPAPPCTLVIFGATGDLARRKLLPALYRLARAGLLPEDLRIIGVGRDDWSDEQWRARVRESLRAFGADGFDDAVWDR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642  82 LSGRLEFCNLDVNDTSGFTRLGDMLDQKNRVTInYFAMPPSTFGAICKGLGEAKLNAKPARVVMEKPLGTSLETSREIND 161
Cdd:PRK12853   81 LAARLSYVQGDVTDPADYARLAEALGPGGNPVF-YLAVPPSLFAPVVENLGAAGLLPEGRRVVLEKPFGHDLASARALNA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642 162 QVGEFFEECQVYRIDHYLGKETVLNLLALRFANSLFVNNWDCRTIDHVEITVAEEVGIEGRWGYFDQAGQMRDMIQNHLL 241
Cdd:PRK12853  160 TLAKVFDEDQIYRIDHFLGKETVQNLLALRFANALLEPLWNRNHIDHVQITVAETLGVEGRGGFYDATGALRDMVQNHLL 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642 242 QILCMIAMSPPSDLSADSIRDEKVKVLKSLRRIDRSNVreKTVRGQYTAGFAQGKKVPGYLEEEGANKTSNTETFVAIRV 321
Cdd:PRK12853  240 QLLALVAMEPPASFDADAVRDEKAKVLRAIRPLDPDDV--HTVRGQYTAGTVGGEPVPGYREEPGVDPDSRTETFVALKL 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642 322 DIDNWRWAGVPFYLRTGKRLPTKCSEVVVYFKTPELNLFKETWQELPqNKLTIRLQPDEGVDIQVLNKVPGLDhkHNLQI 401
Cdd:PRK12853  318 EIDNWRWAGVPFYLRTGKRLAERRTEIVITFKPVPHALFRGTGVEPP-NRLVIRLQPDEGISLELNVKRPGPG--MRLRP 394

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642 402 TKLDLSYSETfnqTHLADAYERLLLETMRGIQALFVRRDEVEEAWKWVDSITEAWAADRDAPKPYQAGTWGPVASVAMIT 481
Cdd:PRK12853  395 VELDADYADD---ERPLEAYERLLLDVLRGDPTLFVRADEVEAAWRIVDPVLDAWAADPVPPHEYPAGSWGPAAADALLA 471


                  ....*.
gi 1230098642 482 RDGRSW 487
Cdd:PRK12853  472 RDGRGW 477
G6PD_C pfam02781
Glucose-6-phosphate dehydrogenase, C-terminal domain;
188-487 3.66e-180

Glucose-6-phosphate dehydrogenase, C-terminal domain;


Pssm-ID: 460694  Cd Length: 295  Bit Score: 506.21  E-value: 3.66e-180
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642 188 LALRFANSLFVNNWDCRTIDHVEITVAEEVGIEGRWGYFDQAGQMRDMIQNHLLQILCMIAMSPPSDLSADSIRDEKVKV 267
Cdd:pfam02781   1 LVLRFANAIFEPLWNRNYIDHVQITVAETLGVEGRGGYYDQAGALRDMVQNHLLQLLALVAMEPPVSFDAEDIRDEKVKV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642 268 LKSLRRIDRSNVREKTVRGQYTAGFAQGKKVPGYLEEEGANKTSNTETFVAIRVDIDNWRWAGVPFYLRTGKRLPTKCSE 347
Cdd:pfam02781  81 LRSLRPITPEDVEDNVVRGQYGAGWIGGEPVPGYREEEGVPPDSRTETFAALKLFIDNWRWAGVPFYLRTGKRLPERVTE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642 348 VVVYFKTPELNLFKETwQELPQNKLTIRLQPDEGVDIQVLNKVPGLDHKhnLQITKLDLSYSETFNqTHLADAYERLLLE 427
Cdd:pfam02781 161 IRIQFKDVPHNLFRDP-GTLPPNELVIRIQPDEGIYLKFNAKVPGLGMR--LRPVELDFSYSDRFG-ERIPEAYERLLLD 236

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642 428 TMRGIQALFVRRDEVEEAWKWVDSITEAWAADRdaPKPYQAGTWGPVASVAMITRDGRSW 487
Cdd:pfam02781 237 VMRGDQTLFVRSDEVEAAWRIVDPILEAWDEEK--PPPYPAGSWGPKAADELLARDGRKW 294
PRK12854 PRK12854
glucose-6-phosphate 1-dehydrogenase; Provisional
 7-489 6.42e-175

glucose-6-phosphate 1-dehydrogenase; Provisional


Pssm-ID: 237234 [Multi-domain]  Cd Length: 484  Bit Score: 500.33  E-value: 6.42e-175
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642   7 AQACDLVIFGAKGDLARRKLLPSLYQLEKAGQIHADTRIIGVGRADWDKAAYTKVVREALETFMKEKIDEGLWDSLSGRL 86
Cdd:PRK12854    9 APPTVFVLFGATGDLAKRKLLPGLFHLARAGLLPPDWRIVGTGRGDVSAEAFREHARDALDEFGARKLDDGEWARFAKRL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642  87 EFCNLDVNDtSGFTRLGDMLDQ------KNRVTINYFAMPPSTFGAICKGLGEAKLnAKPARVVMEKPLGTSLETSREIN 160
Cdd:PRK12854   89 RYVPGGFLS-AGPGALAAAVAAaraelgGDARLVHYLAVPPSAFLDVTRALGEAGL-AEGSRVVMEKPFGTDLASAEALN 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642 161 DQVGEFFEECQVYRIDHYLGKETVLNLLALRFANSLFVNNWDCRTIDHVEITVAEEVGIEGRWGYFDQAGQMRDMIQNHL 240
Cdd:PRK12854  167 AAVHEVFDESQIFRIDHFLGKEAAQNILAFRFANGLFEPIWNREFIDHVQIDVPETLGVDTRAAFYDATGAYRDMVVTHL 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642 241 LQILCMIAMSPPSDLSADSIRDEKVKVLKSLRRIDRSNVrektVRGQYTagfaqgkkvpGYLEEEGANKTSNTETFVAIR 320
Cdd:PRK12854  247 FQVLAFVAMEPPTALEPDAISEEKNKVFRSMRPLDPAEV----VRGQYS----------GYRDEPGVAPDSTTETFVALK 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642 321 VDIDNWRWAGVPFYLRTGKRLPTKCSEVVVYFKTPELNLFKETWQELPQ-NKLTIRLQPDEGVDIQVLNKVPGLDHKhnL 399
Cdd:PRK12854  313 VWIDNWRWAGVPFYLRTGKRMAEGQRIISIAFREPPYSMFPAGSVGAQGpDHLTFDLADNSKVSLSFYGKRPGPGMR--L 390

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642 400 QITKLDLSYSETFNQTHLADAYERLLLETMRGIQALFVRRDEVEEAWKWVDSITEawaaDRDAPKPYQAGTWGPVASVAM 479
Cdd:PRK12854  391 DKLSLQFSLKDTGPKGDVLEAYERLILDALRGDHTLFTTADGIESLWEVSQPLLE----DPPPVKPYAPGSWGPNAIHQL 466

                         490
                  ....*....|....*.
gi 1230098642 480 ITRDG------RSWNE 489
Cdd:PRK12854  467 AAPDAwrlpfeREWRE 482
PTZ00309 PTZ00309
glucose-6-phosphate 1-dehydrogenase; Provisional
 2-484 1.79e-138

glucose-6-phosphate 1-dehydrogenase; Provisional


Pssm-ID: 240353 [Multi-domain]  Cd Length: 542  Bit Score: 409.52  E-value: 1.79e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642   2 AVTQTAQACDLVIFGAKGDLARRKLLPSLYQLEKAGQIHADTRIIGVGRAdwdkaAYTKVVREALETFMKEKI----DEG 77
Cdd:PTZ00309   47 KDEDKSRALTIIVLGASGDLAKKKTFPALFQLYCEGLLPSEVNIVGYARS-----KMSDVERWKKETLARFFKrlddREC 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642  78 LWDSLSGRLEFCNLDVNDTSGFTRLGDMLDQK-----------NRVTinYFAMPPSTFGAICKGLGEAkLNAKPA--RVV 144
Cdd:PTZ00309  122 HLEQFLKHISYISGSYDEDEDFKRLNKLIERMeeafqgpekggNRLF--YLALPPSVFASVCEGIHRG-CMSKNGwvRVI 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642 145 MEKPLGTSLETSREINDQVGEFFEECQVYRIDHYLGKETVLNLLALRFANSLFVNNWDCRTIDHVEITVAEEVGIEGRWG 224
Cdd:PTZ00309  199 VEKPFGRDLESSEELSNQLEPLFDESQLYRIDHYLGKEMVQNLIVLRFANRVFEPLWNRNNIACVQITFKEDIGTEGRGG 278

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642 225 YFDQAGQMRDMIQNHLLQILCMIAMSPPSDLSADSIRDEKVKVLKSLRRIDRSNvrekTVRGQYTAgfAQGKKVPGYLEE 304
Cdd:PTZ00309  279 YFDSYGIIRDVMQNHLLQILALLAMEKPVSLSAEDIRDEKVKVLKCIEPIKMEE----CVLGQYTA--SADGSIPGYLED 352

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642 305 EGANKTSNTETFVAIRVDIDNWRWAGVPFYLRTGKRLPTKCSEVVVYFKTPELNLFkeTWQELPQNKLTIRLQPDEGVDI 384
Cdd:PTZ00309  353 EGVPKDSTTPTFAAAVLHINNDRWEGVPFILEAGKALEERYVEIRIQFKGVDEFRP--SGDDTQRNELVIRAQPSEAMYL 430

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642 385 QVLNKVPGLDHKhnLQITKLDLSYSETFNQThLADAYERLLLETMRGIQALFVRRDEVEEAWKWVDSITEAWAADRDAPK 464
Cdd:PTZ00309  431 KITAKVPGLSND--LHQTELDLTYKTRYNVR-LPDAYERLILDALLGDSTNFVRKDELDVAWRIFTPLLHQIDRGEVKPE 507

                         490       500
                  ....*....|....*....|
gi 1230098642 465 PYQAGTWGPVASVAMITRDG 484
Cdd:PTZ00309  508 PYPFGSRGPKEADELIKKNG 527
PLN02539 PLN02539
glucose-6-phosphate 1-dehydrogenase
 12-484 2.62e-116

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 178154 [Multi-domain]  Cd Length: 491  Bit Score: 350.95  E-value: 2.62e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642  12 LVIFGAKGDLARRKLLPSLYQLEKAGQIHADT-RIIGVGRADWDkaayTKVVREALETFMKEKIDEGLwDSLSGRLEFCN 90
Cdd:PLN02539   20 IIVLGASGDLAKKKTFPALFNLYRQGFLPPDEvHIFGYARSKIT----DEELRDRIRGYLKDEKNAPA-EAVSKFLQLIK 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642  91 L---DVNDTSGFTRLGDMLDQKNRVT---------INYFAMPPSTFGAICKGLGEAKLNAKPA--RVVMEKPLGTSLETS 156
Cdd:PLN02539   95 YvsgAYDSEEGFRRLDKEISEHEISKnsaegssrrLFYLALPPSVYPPVCKMIKKCCMNKSGLwtRIVVEKPFGKDLESA 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642 157 REINDQVGEFFEECQVYRIDHYLGKETVLNLLALRFANSLFVNNWDCRTIDHVEITVAEEVGIEGRWGYFDQAGQMRDMI 236
Cdd:PLN02539  175 EELSSQIGELFDESQLYRIDHYLGKELVQNLLVLRFANRFFLPLWNRDNIANVQIVFREDFGTEGRGGYFDEYGIIRDII 254

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642 237 QNHLLQILCMIAMSPPSDLSADSIRDEKVKVLKSLRRIDRSNVrektVRGQYtagfaqgkkvPGYLEEEGANKTSNTETF 316
Cdd:PLN02539  255 QNHLLQVLCLVAMEKPVSLKPEHIRDEKVKVLQSVEPIKDEEV----VLGQY----------EGYRDDPTVPDDSNTPTF 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642 317 VAIRVDIDNWRWAGVPFYLRTGKRLPTKCSEVVVYFKTPELNLFKEtwQELPQNKLTIRLQPDEGVDIQVLNKVPGLDHK 396
Cdd:PLN02539  321 ASVVLRINNERWEGVPFILKAGKALDSRKAEIRVQFKDVPGDIFKC--QKQGRNEFVIRLQPSEAMYMKLTVKQPGLEMS 398

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642 397 hnLQITKLDLSYSETFNQTHLADAYERLLLETMRGIQALFVRRDEVEEAWKWVDSITEAWAADRDAPKPYQAGTWGPVAS 476
Cdd:PLN02539  399 --TVQSELDLSYGQRYQDVVIPEAYERLILDTIRGDQQHFVRRDELKAAWEIFTPLLHRIDAGKVKPIPYKQGSRGPAEA 476


                  ....*...
gi 1230098642 477 VAMITRDG 484
Cdd:PLN02539  477 DELLEKAG 484
PLN02333 PLN02333
glucose-6-phosphate 1-dehydrogenase
 12-489 1.26e-96

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 215191 [Multi-domain]  Cd Length: 604  Bit Score: 303.82  E-value: 1.26e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642  12 LVIFGAKGDLARRKLLPSLYQLEKAGQIHADTRIIGVGRADWDKAAYTKVVREALETFMK------EKIDEGLwdslsGR 85
Cdd:PLN02333  120 ITVVGASGDLAKKKIFPALFALYYEGCLPEHFTIFGYARSKMTDAELRNMVSKTLTCRIDkrencgEKMEEFL-----KR 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642  86 LEFCNLDVNDTSGFTRLGDMLDQKN--RVT--INYFAMPPSTF--GAICKGLGEAKLNAKpARVVMEKPLGTSLETSREI 159
Cdd:PLN02333  195 CFYHSGQYDSQEHFAELDKKLKEHEggRVSnrLFYLSIPPNIFvdAVKCASSSASSVNGW-TRVIVEKPFGRDSESSAAL 273

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642 160 NDQVGEFFEECQVYRIDHYLGKETVLNLLALRFANSLFVNNWDCRTIDHVEITVAEEVGIEGRWGYFDQAGQMRDMIQNH 239
Cdd:PLN02333  274 TKSLKQYLEEDQIFRIDHYLGKELVENLSVLRFSNLIFEPLWSRQYIRNVQFIFSEDFGTEGRGGYFDNYGIIRDIMQNH 353

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642 240 LLQILCMIAMSPPSDLSADSIRDEKVKVLKSLRRIDRSNVrektVRGQYTAGFAQGKKVPGYLEEEGANKTSNTETFVAI 319
Cdd:PLN02333  354 LLQILALFAMETPVSLDAEDIRNEKVKVLRSMRPIQLEDV----VIGQYKSHTKGGVTYPAYTDDKTVPKGSLTPTFAAA 429

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642 320 RVDIDNWRWAGVPFYLRTGKRLPTKCSEVVVYFKTPELNLFKETW---QELPQNKLTIRLQPDEGVDIQVLNKVPGLDHK 396
Cdd:PLN02333  430 ALFIDNARWDGVPFLMKAGKALHTKSAEIRVQFRHVPGNLYNRNFgtdLDQATNELVIRVQPDEAIYLKINNKVPGLGMR 509

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642 397 hnLQITKLDLSYSETFNQtHLADAYERLLLETMRGIQALFVRRDEVEEAWKWVDSITEAWAADRDAPKPYQAGTWGPVAS 476
Cdd:PLN02333  510 --LDRSNLNLLYAARYSK-EIPDAYERLLLDAIEGERRLFIRSDELDAAWALFTPLLKELEEKKIIPEYYPYGSRGPVGA 586

                         490
                  ....*....|...
gi 1230098642 477 VAMITRDGRSWNE 489
Cdd:PLN02333  587 HYLAARYKVRWGD 599
PLN02640 PLN02640
glucose-6-phosphate 1-dehydrogenase
 12-490 5.91e-96

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 215344 [Multi-domain]  Cd Length: 573  Bit Score: 301.16  E-value: 5.91e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642  12 LVIFGAKGDLARRKLLPSLYQLEKAGQIHADTRIIGVGRadwdkaayTKVVREALETFMKE----KID--EGLWDSLSGR 85
Cdd:PLN02640   91 ITVVGASGDLAKKKIFPALFALFYEDWLPENFTVFGYAR--------TKLTDEELRDMISStltcRIDqrENCGDKMDQF 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642  86 LEFC---NLDVNDTSGFTRLGDMLDQK------NRVTinYFAMPPSTFGAI--CKGLGEAKLNAKpARVVMEKPLGTSLE 154
Cdd:PLN02640  163 LKRCfyhSGQYDSEEDFAELNKKLKEKeagklsNRLF--YLSIPPNIFVDVvrCASLRASSENGW-TRVIVEKPFGRDSE 239

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642 155 TSREINDQVGEFFEECQVYRIDHYLGKETVLNLLALRFANSLFVNNWDCRTIDHVEITVAEEVGIEGRWGYFDQAGQMRD 234
Cdd:PLN02640  240 SSGELTRCLKQYLTEEQIFRIDHYLGKELVENLSVLRFSNLVFEPLWSRNYIRNVQLIFSEDFGTEGRGGYFDNYGIIRD 319

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642 235 MIQNHLLQILCMIAMSPPSDLSADSIRDEKVKVLKSLRRIDRSNVrektVRGQYTAGFAQGKKVPGYLEEEGANKTSNTE 314
Cdd:PLN02640  320 IMQNHLLQILALFAMETPVSLDAEDIRNEKVKVLRSMKPLQLEDV----IVGQYKGHSKGGKSYPAYTDDPTVPKHSLTP 395

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642 315 TFVAIRVDIDNWRWAGVPFYLRTGKRLPTKCSEVVVYFKTPELNLFKETWQ---ELPQNKLTIRLQPDEGVDIQVLNKVP 391
Cdd:PLN02640  396 TFAAAALFINNARWDGVPFLMKAGKALHTRRAEIRVQFRHVPGNLYKRNFGtdlDKATNELVLRVQPDEAIYLKINNKVP 475

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642 392 GLDHKhnLQITKLDLSYSETFNQtHLADAYERLLLETMRGIQALFVRRDEVEEAWKWVDSITEAWAADRDAPKPYQAGTW 471
Cdd:PLN02640  476 GLGMR--LDRSDLNLLYRARYPR-EIPDAYERLLLDAIEGERRLFIRSDELDAAWALFTPLLKELEEKKIIPELYPYGSR 552

                         490
                  ....*....|....*....
gi 1230098642 472 GPVASVAMITRDGRSWNEF 490
Cdd:PLN02640  553 GPVGAHYLAAKYNVRWGDL 571
G6PD_N pfam00479
Glucose-6-phosphate dehydrogenase, NAD binding domain;
13-186 9.96e-81

Glucose-6-phosphate dehydrogenase, NAD binding domain;


Pssm-ID: 459827 [Multi-domain]  Cd Length: 178  Bit Score: 248.49  E-value: 9.96e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642  13 VIFGAKGDLARRKLLPSLYQLEKAGQIHADTRIIGVGRADWDKAAYTKVVREALETFmkEKIDEGLWDSLSGRLEFCNLD 92
Cdd:pfam00479   1 VIFGATGDLAKRKLFPALYNLYRDGLLPEGFRIIGVARRDLSDEEFRERVREALKEF--KELDEEKWDRFLERLHYVSGD 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230098642  93 VNDTSGFTRLGDML----DQKNRVTINYFAMPPSTFGAICKGLGEAKLNAKPA--RVVMEKPLGTSLETSREINDQVGEF 166
Cdd:pfam00479  79 FDDPESYEKLKERLeeheDETRGNRLFYLAVPPSLFGPIAENLGRAGLSEEGGwrRVVIEKPFGHDLESARELNDQLAKV 158

                         170       180
                  ....*....|....*....|
gi 1230098642 167 FEECQVYRIDHYLGKETVLN 186
Cdd:pfam00479 159 FKEEQIYRIDHYLGKETVQN 178
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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