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Conserved domains on  [gi|1228170757|gb|OXY56814|]
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GntR family transcriptional regulator [Salmonella enterica subsp. enterica serovar Enteritidis str. SHSE004]

Protein Classification

GntR family transcriptional regulator( domain architecture ID 11450764)

GntR-family transcriptional regulator is one of a group of transcriptional regulators with a conserved N-terminal helix-turn-helix DNA-binding domain and a diverse C-terminal effector-binding and oligomerization domain

Gene Ontology:  GO:0003677|GO:0003700
PubMed:  2060763|26172911|33509775|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
6-234 6.35e-51

DNA-binding transcriptional regulator, GntR family [Transcription];


:

Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 165.81  E-value: 6.35e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228170757   6 TSFTPLYKQLFFIICQQIQNGSLPLGSQLPTQKEIARAYNVSLIVVKQAWSELINAGIISSQRGSGSVVCSVPEGVSYGH 85
Cdd:COG2188     1 SSPVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228170757  86 tFRGITRDLQDASVAIENRILEIAPRRARDAQADGLSLPAQHHYLYISRIRCLNNRPFNHEKIYLDLSFFPGleLTPQAL 165
Cdd:COG2188    81 -LTSFTEELRARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPG--LLEEDL 157

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1228170757 166 EHTSLYSLL----NVTSDSAIEKVEAILPSADLCEKLQIAANKPLLSVARQTFQAgQDNPFEYCRYYVLSEYF 234
Cdd:COG2188   158 ETGSLYELLeeryGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDA-DGRPVEYSRSYYRGDRY 229
 
Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
6-234 6.35e-51

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 165.81  E-value: 6.35e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228170757   6 TSFTPLYKQLFFIICQQIQNGSLPLGSQLPTQKEIARAYNVSLIVVKQAWSELINAGIISSQRGSGSVVCSVPEGVSYGH 85
Cdd:COG2188     1 SSPVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228170757  86 tFRGITRDLQDASVAIENRILEIAPRRARDAQADGLSLPAQHHYLYISRIRCLNNRPFNHEKIYLDLSFFPGleLTPQAL 165
Cdd:COG2188    81 -LTSFTEELRARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPG--LLEEDL 157

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1228170757 166 EHTSLYSLL----NVTSDSAIEKVEAILPSADLCEKLQIAANKPLLSVARQTFQAgQDNPFEYCRYYVLSEYF 234
Cdd:COG2188   158 ETGSLYELLeeryGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDA-DGRPVEYSRSYYRGDRY 229
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 102-234 4.01e-26

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 98.82  E-value: 4.01e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228170757 102 ENRILEIAPRRARDAQADGLSLPAQHHYLYISRIRCLNNRPFNHEKIYLDLSFFPGleLTPQALEHTSLYSLL----NVT 177
Cdd:pfam07702   7 KTEVLSLEEVPASAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAELVPD--LLEEDLEEGSLYDYLeeryGLP 84

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1228170757 178 SDSAIEKVEAILPSADLCEKLQIAANKPLLSVARQTFQAGqDNPFEYCRYYVLSEYF 234
Cdd:pfam07702  85 ITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDQD-GRPVEYSRSYYRGDRY 140
PRK09764 PRK09764
GntR family transcriptional regulator;
10-228 1.81e-22

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 91.81  E-value: 1.81e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228170757  10 PLYKQLFFIICQQIQNGSLPLGSQLPTQKEIARAYNVSLIVVKQAWSELINAGIISSQRGSGSVVCSvpEGVSYG-HTFR 88
Cdd:PRK09764    5 PLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKE--ERVNYDiFQLT 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228170757  89 GITRDLQDASVAIENRILEIAPRRARDAQADGLSLPAQHHYLYISRIRCLNNRPFNHEKIYLDLSFFPglELTPQALEhT 168
Cdd:PRK09764   83 SFDEKLSDRHVDTHSEVLIFEVIPADDFLQQQLQITAQDRVWHVKRVRYRKQKPMALEETWMPLALFP--DLTWQVME-N 159

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1228170757 169 SLYSLLNVTSDSAIEKVE----AILPSADLCEKLQIAANKPLLS-VARQTFQAGQdnPFEYCRYY 228
Cdd:PRK09764  160 SKYHFIEEVKKMVIDRSEqeiiPLMPTEEMSRLLNISQTKPILEkVSRGYLVDGR--VFEYSRNA 222
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 102-234 5.28e-22

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 88.12  E-value: 5.28e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228170757  102 ENRILEIAPRRARDAQADGLSLPAQHHYLYISRIRCLNNRPFNHEKIYLDLSFFPGLeltPQALEHTSLYSLLN------ 175
Cdd:smart00866   7 TTKVLSFERVPADEELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAALFPGL---LEEDLSGSLYEYLEerlglk 83

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228170757  176 -VTSDSAIEKVEAILPSADLCEKLQIAANKPLLSVARQTFQAgQDNPFEYCRYYVLSEYF 234
Cdd:smart00866  84 iVRSTRAEQTITAVLADEEEAELLGLPPGAPLLVVERVTYDD-DGRPVEYSRSYYRGDRF 142
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 10-75 1.26e-17

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 74.41  E-value: 1.26e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1228170757  10 PLYKQLFFIICQQIQNGSLPLGSQLPTQKEIARAYNVSLIVVKQAWSELINAGIISSQRGSGSVVC 75
Cdd:cd07377     1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
 
Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
6-234 6.35e-51

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 165.81  E-value: 6.35e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228170757   6 TSFTPLYKQLFFIICQQIQNGSLPLGSQLPTQKEIARAYNVSLIVVKQAWSELINAGIISSQRGSGSVVCSVPEGVSYGH 85
Cdd:COG2188     1 SSPVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228170757  86 tFRGITRDLQDASVAIENRILEIAPRRARDAQADGLSLPAQHHYLYISRIRCLNNRPFNHEKIYLDLSFFPGleLTPQAL 165
Cdd:COG2188    81 -LTSFTEELRARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPG--LLEEDL 157

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1228170757 166 EHTSLYSLL----NVTSDSAIEKVEAILPSADLCEKLQIAANKPLLSVARQTFQAgQDNPFEYCRYYVLSEYF 234
Cdd:COG2188   158 ETGSLYELLeeryGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDA-DGRPVEYSRSYYRGDRY 229
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 102-234 4.01e-26

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 98.82  E-value: 4.01e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228170757 102 ENRILEIAPRRARDAQADGLSLPAQHHYLYISRIRCLNNRPFNHEKIYLDLSFFPGleLTPQALEHTSLYSLL----NVT 177
Cdd:pfam07702   7 KTEVLSLEEVPASAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAELVPD--LLEEDLEEGSLYDYLeeryGLP 84

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1228170757 178 SDSAIEKVEAILPSADLCEKLQIAANKPLLSVARQTFQAGqDNPFEYCRYYVLSEYF 234
Cdd:pfam07702  85 ITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDQD-GRPVEYSRSYYRGDRY 140
PRK09764 PRK09764
GntR family transcriptional regulator;
10-228 1.81e-22

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 91.81  E-value: 1.81e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228170757  10 PLYKQLFFIICQQIQNGSLPLGSQLPTQKEIARAYNVSLIVVKQAWSELINAGIISSQRGSGSVVCSvpEGVSYG-HTFR 88
Cdd:PRK09764    5 PLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKE--ERVNYDiFQLT 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228170757  89 GITRDLQDASVAIENRILEIAPRRARDAQADGLSLPAQHHYLYISRIRCLNNRPFNHEKIYLDLSFFPglELTPQALEhT 168
Cdd:PRK09764   83 SFDEKLSDRHVDTHSEVLIFEVIPADDFLQQQLQITAQDRVWHVKRVRYRKQKPMALEETWMPLALFP--DLTWQVME-N 159

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1228170757 169 SLYSLLNVTSDSAIEKVE----AILPSADLCEKLQIAANKPLLS-VARQTFQAGQdnPFEYCRYY 228
Cdd:PRK09764  160 SKYHFIEEVKKMVIDRSEqeiiPLMPTEEMSRLLNISQTKPILEkVSRGYLVDGR--VFEYSRNA 222
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 102-234 5.28e-22

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 88.12  E-value: 5.28e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228170757  102 ENRILEIAPRRARDAQADGLSLPAQHHYLYISRIRCLNNRPFNHEKIYLDLSFFPGLeltPQALEHTSLYSLLN------ 175
Cdd:smart00866   7 TTKVLSFERVPADEELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAALFPGL---LEEDLSGSLYEYLEerlglk 83

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228170757  176 -VTSDSAIEKVEAILPSADLCEKLQIAANKPLLSVARQTFQAgQDNPFEYCRYYVLSEYF 234
Cdd:smart00866  84 iVRSTRAEQTITAVLADEEEAELLGLPPGAPLLVVERVTYDD-DGRPVEYSRSYYRGDRF 142
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 10-75 1.26e-17

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 74.41  E-value: 1.26e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1228170757  10 PLYKQLFFIICQQIQNGSLPLGSQLPTQKEIARAYNVSLIVVKQAWSELINAGIISSQRGSGSVVC 75
Cdd:cd07377     1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
YhcF COG1725
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
1-76 2.86e-16

DNA-binding transcriptional regulator YhcF, GntR family [Transcription];


Pssm-ID: 441331 [Multi-domain]  Cd Length: 114  Bit Score: 72.13  E-value: 2.86e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1228170757   1 MQVDKTSFTPLYKQLFFIICQQIQNGSLPLGSQLPTQKEIARAYNVSLIVVKQAWSELINAGIISSQRGSGSVVCS 76
Cdd:COG1725     1 IRIDFDSGVPIYEQIADQIKEAIASGELKPGDRLPSVRELAAELGVNPNTVAKAYRELEDEGLIETRRGKGTFVAE 76
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 1-78 2.97e-14

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 71.40  E-value: 2.97e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1228170757   1 MQVDKTSFTPLYKQLFFIICQQIQNGSLPLGSQLPTQKEIARAYNVSLIVVKQAWSELINAGIISSQRGSGSVVCSVP 78
Cdd:COG1167     3 IRLDRDSSGPLYLQLADALREAILSGRLPPGDRLPSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFVAARL 80
PRK11402 PRK11402
transcriptional regulator PhoB;
4-159 6.31e-14

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 68.71  E-value: 6.31e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228170757   4 DKTSFTPLYKQLFFIICQQIQNGSLPLGSQLPTQKEIARAYNVSLIVVKQAWSELINAGIISSQRGSGSVVCSvPEGVSY 83
Cdd:PRK11402    3 DRYSHQLLYATVRQRLLDDIAQGVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQS-QKVENA 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1228170757  84 GHTFRGITRDLQDASVAIENRILEIApRRARDAQADGLSLPAQHHYLYISRIRCLNNRPFNHEKIYLDLSFFPGLE 159
Cdd:PRK11402   82 LLTVSGFTDFGVSQGKATKEKVIEQE-RVSAAPFCEKLNIPGNSEVFHLCRVMYLDKEPLFIDSSWIPLSRYPDFD 156
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
9-121 3.92e-11

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 60.72  E-value: 3.92e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228170757   9 TPLYKQLFFIICQQIQNGSLPLGSQLPTQKEIARAYNVSLIVVKQAWSELINAGIISSQRGSGSVVCSVP-----EGVSY 83
Cdd:COG2186     6 RSLAEQVAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPSpwallDPLAL 85

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1228170757  84 GHTFRGIT-RDLQDASVAIENRILEIAPRRARDAQADGL 121
Cdd:COG2186    86 LLALDDASlRDLLEARLALEPEAARLAAERATDEDLARL 124
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
21-74 1.73e-10

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 55.27  E-value: 1.73e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1228170757   21 QQIQNGSLPLGSQLPTQKEIARAYNVSLIVVKQAWSELINAGIISSQRGSGSVV 74
Cdd:smart00345   7 EDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 11-74 2.49e-10

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 54.93  E-value: 2.49e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1228170757  11 LYKQLFFIICQQIQNGSLPLGSQLPTQKEIARAYNVSLIVVKQAWSELINAGIISSQRGSGSVV 74
Cdd:pfam00392   1 LYEQVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
PRK14999 PRK14999
histidine utilization repressor; Provisional
 1-218 1.44e-07

histidine utilization repressor; Provisional


Pssm-ID: 184961 [Multi-domain]  Cd Length: 241  Bit Score: 50.70  E-value: 1.44e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228170757   1 MQVDKTSFTPLYKQLFFIICQQIQNGSLPLGSQLPTQKEIARAYNVSLIVVKQAWSELINAGIISSQRGSGSVVCSvPEG 80
Cdd:PRK14999    3 SSRSRSAPAPFYETVKQDICKKIAGGVWQPHDRIPSEAELVAQYGFSRMTINRALRELTDEGWLVRLQGVGTFVAE-PKG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228170757  81 VSYGHTFRGITRDLQDASVAIENRILEIAPRRARDAQADGLSLPAQHHYLYISRIRCLNNRPFNHEKIYLDLSFFPG--L 158
Cdd:PRK14999   82 QSALFEVRSIAEEIAARRHQHRCEVLTLERVRANAIQASALNVNESDVIFHSIMVHYENDLPVQIEDRCVNADIAVDylT 161

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228170757 159 ELTPQALEHTSLYSLLNVTSDSAIekVEAILPSADLCEKLQIAANKPLLSVARQTFQAGQ 218
Cdd:PRK14999  162 QDYRQTTPHAYLSRIAPLTEGEHI--VEAVRATAQECAWLTIKEHEPCLLIRRTTWSASR 219
PRK11523 PRK11523
transcriptional regulator ExuR;
11-76 5.78e-06

transcriptional regulator ExuR;


Pssm-ID: 183176 [Multi-domain]  Cd Length: 253  Bit Score: 45.99  E-value: 5.78e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1228170757  11 LYKQLFFIICQQIQNGSLPLGSQLPTQKEIARAYNVSLIVVKQAWSELINAGIISSQRGSGSVVCS 76
Cdd:PRK11523    9 LYQQLAAELKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYVEVRKGSGIHVVS 74
PRK10079 PRK10079
phosphonate metabolism transcriptional regulator PhnF; Provisional
 31-224 3.24e-05

phosphonate metabolism transcriptional regulator PhnF; Provisional


Pssm-ID: 182227 [Multi-domain]  Cd Length: 241  Bit Score: 43.61  E-value: 3.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228170757  31 GSQLPTQKEIARAYNVSLIVVKQAWSELINAGIISSQRGSGSVVCSVPEGVSYGHTFRGITRDLQDASVAIENRILEIAp 110
Cdd:PRK10079   32 GDYLPAEQQLAARYEVNRHTLRRAIDQLVEKGWVQRRQGVGVLVLMRPYDYPLNAQARFSQNLLDQGSHPTSEKLLSVL- 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228170757 111 RRARDAQADGLSLPAQHHYLYISRIRCLNNRP---FNHekiYL-DLSFFPGLeltpQALEHTSLYSLLNVTSDSAIE--- 183
Cdd:PRK10079  111 RPASGHVADALGITEGENVIHLRTLRRVNGVAlclIDH---YFaDLTWWPTL----QRFDSGSLHDFLREQLGIALRrsq 183

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1228170757 184 -KVEAILPSADLCEKLQIAANKPLLSVARQTFQAGQDNPFEY 224
Cdd:PRK10079  184 tRISARRAQAKESQLLEIPNMSPLLCVRTLNHRDGESSPAEY 225
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
9-121 4.80e-05

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 42.99  E-value: 4.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228170757   9 TPLYKQLFFIICQQIQNGSLPLGSQLpTQKEIARAYNVSLIVVKQAWSELINAGIISSQRGSGSVVCSVpegvsyghTFR 88
Cdd:COG1802    10 ESLAEQVYEALREAILSGELPPGERL-SEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPL--------SPE 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1228170757  89 GItRDLQDASVAIENRILEIAPRRARDAQADGL 121
Cdd:COG1802    81 EI-RELYEVRAALEGLAARLAAERATPADLARL 112
PRK15481 PRK15481
transcriptional regulatory protein PtsJ; Provisional
 14-79 2.33e-04

transcriptional regulatory protein PtsJ; Provisional


Pssm-ID: 185378 [Multi-domain]  Cd Length: 431  Bit Score: 41.57  E-value: 2.33e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1228170757  14 QLFFIICQQIQNGSLPLGSQLPTQKEIARAYNVSLIVVKQAWSELINAGIISSQRGSGSVVCSVPE 79
Cdd:PRK15481    9 EIFDSIRQLIQAGRLRPGDSLPPVRELASELGVNRNTVAAAYKRLVTAGLAQSQGRNGTVIRGSPS 74
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 23-79 2.15e-03

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 38.21  E-value: 2.15e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1228170757  23 IQNGSLPLGSQLPTQKEIARAYNVSLIVVKQAWSELINAGIISSQRGSGSVVCSVPE 79
Cdd:PRK10421   15 IEEKNLEAGMKLPAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFIRWRHE 71
Rrf2 pfam02082
Iron-dependent Transcriptional regulator; Several proteins in this family form iron-sulfur ...
 38-71 2.22e-03

Iron-dependent Transcriptional regulator; Several proteins in this family form iron-sulfur clusters enabling iron dependent DNA transcription regulation. The iron binding is mediated by three conserved cysteine residues. Members of this family can also bind O-acetyl-L-serine, [Fe-S] and nitric oxide (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 396591 [Multi-domain]  Cd Length: 131  Bit Score: 37.15  E-value: 2.22e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1228170757  38 KEIARAYNVSLIVVKQAWSELINAGIISSQRGSG 71
Cdd:pfam02082  27 EEIAERQNISPVYLEKILAKLRKAGLVESVRGAG 60
IscR COG1959
DNA-binding transcriptional regulator, IscR family [Transcription];
38-71 4.57e-03

DNA-binding transcriptional regulator, IscR family [Transcription];


Pssm-ID: 441562  Cd Length: 141  Bit Score: 36.36  E-value: 4.57e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1228170757  38 KEIARAYNVSLIVVKQAWSELINAGIISSQRGSG 71
Cdd:COG1959    28 KEIAERQGISPSYLEKILQKLRKAGLVESVRGPG 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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