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Conserved domains on  [gi|1227767113|gb|OXX06406|]
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protein AmpE [Shigella sonnei]

Protein Classification

beta-lactamase regulator AmpE( domain architecture ID 11247057)

beta-lactamase regulator AmpE, an ampicillin resistance inner membrane regulatory protein, is a putative signaling protein involved in regulation of beta-lactamase

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AmpE pfam17113
Regulatory signalling modulator protein AmpE; AmpE is a family of bacterial regulatory ...
 1-284 1.96e-169

Regulatory signalling modulator protein AmpE; AmpE is a family of bacterial regulatory proteins. AmpE in conjunction with AmpD sense the effect of beta-lactam on peptidoglycan synthesis and relay this signal to AmpR. AmpR regulates the production of beta-lactamase.


:

Pssm-ID: 374997  Cd Length: 284  Bit Score: 470.00  E-value: 1.96e-169
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227767113   1 MTLFTTLLVLIFERLFKLGEHWQLDHRLEAFFRRVKHFSLGRTLGMTIIAMGVTFLLLRALQGVLFNVPTLLVWLLIGLL 80
Cdd:pfam17113   1 MTLFTLLLVLAWERLFKLGEHWQLDHRLEVVFRRLQHFSLVQTLLLTIVWMVVVWAILRLLQGILFGLPLLLLWILLGLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227767113  81 CIGAGKVRLHYHAYLTAASRNDSHARATMAGELTMIHGVPAGCDEREYLRELQNALLWINFRFYLAPLFWLIVGGTWGPV 160
Cdd:pfam17113  81 CIGAGKIRQHYHAYLKAARRGDADACKAMAEELALIHGLPPDCSERERLRELQNALLWINFRYYLAPLFWFVVGGPYGPV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227767113 161 TLMGYAFLRAWQYWLARYQTPHHRLQSGIDAVLHVLDWVPVRLAGVVYALIGHGEKALPAWFASLGDFHTSQYQVLTRLA 240
Cdd:pfam17113 161 TLVGYAVLRAWQTWLARHHTPLERAQSGVDALLHWLDWIPVRLAGVAYALLGHGEKALPAWFASLGDIHSSQYQVLTRLA 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1227767113 241 QFSLAREPHVDKVETPKAAVSMAKKTSFVVVVVIALLTIYGALV 284
Cdd:pfam17113 241 QFSLAREPHTDPVQTPRAAVSLAKKVTLVIVVVVALLTIYGTLV 284
 
Name Accession Description Interval E-value
AmpE pfam17113
Regulatory signalling modulator protein AmpE; AmpE is a family of bacterial regulatory ...
 1-284 1.96e-169

Regulatory signalling modulator protein AmpE; AmpE is a family of bacterial regulatory proteins. AmpE in conjunction with AmpD sense the effect of beta-lactam on peptidoglycan synthesis and relay this signal to AmpR. AmpR regulates the production of beta-lactamase.


Pssm-ID: 374997  Cd Length: 284  Bit Score: 470.00  E-value: 1.96e-169
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227767113   1 MTLFTTLLVLIFERLFKLGEHWQLDHRLEAFFRRVKHFSLGRTLGMTIIAMGVTFLLLRALQGVLFNVPTLLVWLLIGLL 80
Cdd:pfam17113   1 MTLFTLLLVLAWERLFKLGEHWQLDHRLEVVFRRLQHFSLVQTLLLTIVWMVVVWAILRLLQGILFGLPLLLLWILLGLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227767113  81 CIGAGKVRLHYHAYLTAASRNDSHARATMAGELTMIHGVPAGCDEREYLRELQNALLWINFRFYLAPLFWLIVGGTWGPV 160
Cdd:pfam17113  81 CIGAGKIRQHYHAYLKAARRGDADACKAMAEELALIHGLPPDCSERERLRELQNALLWINFRYYLAPLFWFVVGGPYGPV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227767113 161 TLMGYAFLRAWQYWLARYQTPHHRLQSGIDAVLHVLDWVPVRLAGVVYALIGHGEKALPAWFASLGDFHTSQYQVLTRLA 240
Cdd:pfam17113 161 TLVGYAVLRAWQTWLARHHTPLERAQSGVDALLHWLDWIPVRLAGVAYALLGHGEKALPAWFASLGDIHSSQYQVLTRLA 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1227767113 241 QFSLAREPHVDKVETPKAAVSMAKKTSFVVVVVIALLTIYGALV 284
Cdd:pfam17113 241 QFSLAREPHTDPVQTPRAAVSLAKKVTLVIVVVVALLTIYGTLV 284
PRK10987 PRK10987
beta-lactamase regulator AmpE;
1-284 9.89e-160

beta-lactamase regulator AmpE;


Pssm-ID: 236811  Cd Length: 284  Bit Score: 445.52  E-value: 9.89e-160
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227767113   1 MTLFTTLLVLIFERLFKLGEHWQLDHRLEAFFRRVKHFSLGRTLGMTIIAMGVTFLLLRALQGVLFNVPTLLVWLLIGLL 80
Cdd:PRK10987    1 MTLFSLLLVLIVERLFKLGEHWQLDHRLEAFFRRKKHFSLLRTLLALLLPMLVVFLLLWLLQGLLFGVPTLLLWILIGLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227767113  81 CIGAGKVRLHYHAYLTAASRNDSHARATMAGELTMIHGVPAGCDEREYLRELQNALLWINFRFYLAPLFWLIVGGTWGPV 160
Cdd:PRK10987   81 CIGAGKQRLHYKAYLQAACRGDSQACYHMAEELTLIHGLPADVSERELLRELQQALLWINYRYYLAPLFWFIVLGPWGAV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227767113 161 TLMGYAFLRAWQYWLARYQTPHHRLQSGIDAVLHVLDWVPVRLAGVVYALIGHGEKALPAWFASLGDFHTSQYQVLTRLA 240
Cdd:PRK10987  161 LLMGYAFLRAYQEWLARYQTPLPRAQSGIDALLHVLDWLPVRLAGFGYALLGHFEKALPAWFASLLDFHTSQYQVLTRLA 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1227767113 241 QFSLAREPHVDKVETPKAAVSMAKKTSFVVVVVIALLTIYGALV 284
Cdd:PRK10987  241 QFSLAREPHLDCVQTPLAAVSLAKRNFLLLVVVIALLTIYGALV 284
AmpE COG3725
Membrane protein AmpE required for beta-lactamase induction [Defense mechanisms];
1-284 1.68e-96

Membrane protein AmpE required for beta-lactamase induction [Defense mechanisms];


Pssm-ID: 442939  Cd Length: 289  Bit Score: 285.26  E-value: 1.68e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227767113   1 MTLFTTLLVLIFERLFKLGEHWQLDHRLEAFFRRV-------KHFSLGRTLGMTIIAMGVTFLLLRALQGVLFNVPTLLV 73
Cdd:COG3725     1 MTLLTLLLALLLERLFKLGARWQRDHWFQRWLRRLerrpslaRWSSLLGLLLAVLLPVLVVALLLWLLSGVLFGLLTLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227767113  74 WLLIGLLCIGAGKVRLHYHAYLTAASRNDSHARATMAGELTMIHGvPAGCDEREYLRELQNALLWINFRFYLAPLFWLIV 153
Cdd:COG3725    81 WVLVLLYCLGPGDLRADVRAYLKAARRGDRQAAYHMAEELLGIHG-PADDSEEELLRQVQEALLWRNFRRYFAVLFWFVV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227767113 154 GGTWGPVtlmGYAFLRAWQYWLARYQTPhhRLQSGIDAVLHVLDWVPVRLAGVVYALIGHGEKALPAWFASLGDFHTSQY 233
Cdd:COG3725   160 LGPAGAL---LYRLLRLYARWLARHHLP--AARSGADRLLHWLDWIPARLLALSYALVGNFVAALPAWRASLGDRHTSAA 234

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1227767113 234 QVLTRLAQFSLAREPHVD----KVETPKAAVSMAKKTSFVVVVVIALLTIYGALV 284
Cdd:COG3725   235 DVLTAVARAALELDPEADdgarGVAELEAAVSLLKRALLVWLAVVALLTIAGWLV 289
 
Name Accession Description Interval E-value
AmpE pfam17113
Regulatory signalling modulator protein AmpE; AmpE is a family of bacterial regulatory ...
 1-284 1.96e-169

Regulatory signalling modulator protein AmpE; AmpE is a family of bacterial regulatory proteins. AmpE in conjunction with AmpD sense the effect of beta-lactam on peptidoglycan synthesis and relay this signal to AmpR. AmpR regulates the production of beta-lactamase.


Pssm-ID: 374997  Cd Length: 284  Bit Score: 470.00  E-value: 1.96e-169
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227767113   1 MTLFTTLLVLIFERLFKLGEHWQLDHRLEAFFRRVKHFSLGRTLGMTIIAMGVTFLLLRALQGVLFNVPTLLVWLLIGLL 80
Cdd:pfam17113   1 MTLFTLLLVLAWERLFKLGEHWQLDHRLEVVFRRLQHFSLVQTLLLTIVWMVVVWAILRLLQGILFGLPLLLLWILLGLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227767113  81 CIGAGKVRLHYHAYLTAASRNDSHARATMAGELTMIHGVPAGCDEREYLRELQNALLWINFRFYLAPLFWLIVGGTWGPV 160
Cdd:pfam17113  81 CIGAGKIRQHYHAYLKAARRGDADACKAMAEELALIHGLPPDCSERERLRELQNALLWINFRYYLAPLFWFVVGGPYGPV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227767113 161 TLMGYAFLRAWQYWLARYQTPHHRLQSGIDAVLHVLDWVPVRLAGVVYALIGHGEKALPAWFASLGDFHTSQYQVLTRLA 240
Cdd:pfam17113 161 TLVGYAVLRAWQTWLARHHTPLERAQSGVDALLHWLDWIPVRLAGVAYALLGHGEKALPAWFASLGDIHSSQYQVLTRLA 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1227767113 241 QFSLAREPHVDKVETPKAAVSMAKKTSFVVVVVIALLTIYGALV 284
Cdd:pfam17113 241 QFSLAREPHTDPVQTPRAAVSLAKKVTLVIVVVVALLTIYGTLV 284
PRK10987 PRK10987
beta-lactamase regulator AmpE;
1-284 9.89e-160

beta-lactamase regulator AmpE;


Pssm-ID: 236811  Cd Length: 284  Bit Score: 445.52  E-value: 9.89e-160
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227767113   1 MTLFTTLLVLIFERLFKLGEHWQLDHRLEAFFRRVKHFSLGRTLGMTIIAMGVTFLLLRALQGVLFNVPTLLVWLLIGLL 80
Cdd:PRK10987    1 MTLFSLLLVLIVERLFKLGEHWQLDHRLEAFFRRKKHFSLLRTLLALLLPMLVVFLLLWLLQGLLFGVPTLLLWILIGLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227767113  81 CIGAGKVRLHYHAYLTAASRNDSHARATMAGELTMIHGVPAGCDEREYLRELQNALLWINFRFYLAPLFWLIVGGTWGPV 160
Cdd:PRK10987   81 CIGAGKQRLHYKAYLQAACRGDSQACYHMAEELTLIHGLPADVSERELLRELQQALLWINYRYYLAPLFWFIVLGPWGAV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227767113 161 TLMGYAFLRAWQYWLARYQTPHHRLQSGIDAVLHVLDWVPVRLAGVVYALIGHGEKALPAWFASLGDFHTSQYQVLTRLA 240
Cdd:PRK10987  161 LLMGYAFLRAYQEWLARYQTPLPRAQSGIDALLHVLDWLPVRLAGFGYALLGHFEKALPAWFASLLDFHTSQYQVLTRLA 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1227767113 241 QFSLAREPHVDKVETPKAAVSMAKKTSFVVVVVIALLTIYGALV 284
Cdd:PRK10987  241 QFSLAREPHLDCVQTPLAAVSLAKRNFLLLVVVIALLTIYGALV 284
AmpE COG3725
Membrane protein AmpE required for beta-lactamase induction [Defense mechanisms];
1-284 1.68e-96

Membrane protein AmpE required for beta-lactamase induction [Defense mechanisms];


Pssm-ID: 442939  Cd Length: 289  Bit Score: 285.26  E-value: 1.68e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227767113   1 MTLFTTLLVLIFERLFKLGEHWQLDHRLEAFFRRV-------KHFSLGRTLGMTIIAMGVTFLLLRALQGVLFNVPTLLV 73
Cdd:COG3725     1 MTLLTLLLALLLERLFKLGARWQRDHWFQRWLRRLerrpslaRWSSLLGLLLAVLLPVLVVALLLWLLSGVLFGLLTLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227767113  74 WLLIGLLCIGAGKVRLHYHAYLTAASRNDSHARATMAGELTMIHGvPAGCDEREYLRELQNALLWINFRFYLAPLFWLIV 153
Cdd:COG3725    81 WVLVLLYCLGPGDLRADVRAYLKAARRGDRQAAYHMAEELLGIHG-PADDSEEELLRQVQEALLWRNFRRYFAVLFWFVV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227767113 154 GGTWGPVtlmGYAFLRAWQYWLARYQTPhhRLQSGIDAVLHVLDWVPVRLAGVVYALIGHGEKALPAWFASLGDFHTSQY 233
Cdd:COG3725   160 LGPAGAL---LYRLLRLYARWLARHHLP--AARSGADRLLHWLDWIPARLLALSYALVGNFVAALPAWRASLGDRHTSAA 234

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1227767113 234 QVLTRLAQFSLAREPHVD----KVETPKAAVSMAKKTSFVVVVVIALLTIYGALV 284
Cdd:COG3725   235 DVLTAVARAALELDPEADdgarGVAELEAAVSLLKRALLVWLAVVALLTIAGWLV 289
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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