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Conserved domains on  [gi|1195228146|gb|OUG69645|]
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general secretion pathway protein B [Klebsiella pneumoniae]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
T2SS_GspB NF037978
type II secretion system assembly factor GspB; GspB (general secretory pathway B) occurs in ...
 31-175 1.96e-68

type II secretion system assembly factor GspB; GspB (general secretory pathway B) occurs in type II secretion systems (T2SS) and is viewed as an accessory protein, a factor involved in the assembly process rather than integral to the completed T2SS apparatus.


:

Pssm-ID: 468297 [Multi-domain]  Cd Length: 158  Bit Score: 205.36  E-value: 1.96e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195228146  31 GRMVQIPGWIIPLYAGLFIALGWFGGEQWRHP----------APPQTLPLPVAHAALLPLT-AAGEAAPKTPPPAAKASA 99
Cdd:NF037978    3 GRMYRIPGYLLVVYALLLIALGWFGHQQWRSPsepiappaarPAPQPAAAPVAHAALVPLQqTSAATPDAPVQAAPLKSA 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1195228146 100 PAAPEVDSDTLPPLRYSAHVYASLPEKRSIVLNGKAWTEGDSPLPNLVVEQIQQDVTIFSFNGTTFTLAALEDWPG 175
Cdd:NF037978   83 LAAPTVDRGELPPLAYSAHVYTSDPEKRSIVLNGERYREGDSPLPGLVIEQIQQDMTIFSFNGETFTLAALQDWPG 158
 
Name Accession Description Interval E-value
T2SS_GspB NF037978
type II secretion system assembly factor GspB; GspB (general secretory pathway B) occurs in ...
 31-175 1.96e-68

type II secretion system assembly factor GspB; GspB (general secretory pathway B) occurs in type II secretion systems (T2SS) and is viewed as an accessory protein, a factor involved in the assembly process rather than integral to the completed T2SS apparatus.


Pssm-ID: 468297 [Multi-domain]  Cd Length: 158  Bit Score: 205.36  E-value: 1.96e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195228146  31 GRMVQIPGWIIPLYAGLFIALGWFGGEQWRHP----------APPQTLPLPVAHAALLPLT-AAGEAAPKTPPPAAKASA 99
Cdd:NF037978    3 GRMYRIPGYLLVVYALLLIALGWFGHQQWRSPsepiappaarPAPQPAAAPVAHAALVPLQqTSAATPDAPVQAAPLKSA 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1195228146 100 PAAPEVDSDTLPPLRYSAHVYASLPEKRSIVLNGKAWTEGDSPLPNLVVEQIQQDVTIFSFNGTTFTLAALEDWPG 175
Cdd:NF037978   83 LAAPTVDRGELPPLAYSAHVYTSDPEKRSIVLNGERYREGDSPLPGLVIEQIQQDMTIFSFNGETFTLAALQDWPG 158
T2SSB pfam16537
Type II secretion system protein B; This is the B protein from some operons of bacterial ...
 110-169 1.39e-21

Type II secretion system protein B; This is the B protein from some operons of bacterial secretion systems of type II. The exact function of the B protein is not known, though in the case of Vibrio cholerae there is a fusion protein between proteins A and B that includes an AAA domain, a PG_binding domains well as this domain at the C-terminus. Many of the other species have no A or B domain genes in this operon. The type II secretion pathway is conserved in Gram-negative bacteria that are prevalent in bacterial pathogens of plants (Pseudomonas fluorescens, Erwinia or Xanthomonas species), animals (Aeromonas hydrophila) and humans (Klebsiella oxytoca, Pseudomonas aeruginosa, Vibrio cholerae or Legionella pneumophila). Typical type II secretion systems (T2SSs) are encoded by a set of 12 to 16 gsp (general secretion pathway) genes organized into large operons including the conserved 'core' genes denoted C to O and in some bacterial species, as indicated above, extra gsp genes such as gspAB, gspN or gspS. A different nomenclature is used for Pseudomonas T2SSs, so the B gene is referred to as the P protein.


Pssm-ID: 435407  Cd Length: 60  Bit Score: 83.00  E-value: 1.39e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195228146 110 LPPLRYSAHVYASLPEKRSIVLNGKAWTEGDSPLPNLVVEQIQQDVTIFSFNGTTFTLAA 169
Cdd:pfam16537   1 LPALAYSAHVYSSNPANRWVIINGQELREGDTIAPGLTLEEIRPDGVVLRFDGQRFRLPA 60
 
Name Accession Description Interval E-value
T2SS_GspB NF037978
type II secretion system assembly factor GspB; GspB (general secretory pathway B) occurs in ...
 31-175 1.96e-68

type II secretion system assembly factor GspB; GspB (general secretory pathway B) occurs in type II secretion systems (T2SS) and is viewed as an accessory protein, a factor involved in the assembly process rather than integral to the completed T2SS apparatus.


Pssm-ID: 468297 [Multi-domain]  Cd Length: 158  Bit Score: 205.36  E-value: 1.96e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195228146  31 GRMVQIPGWIIPLYAGLFIALGWFGGEQWRHP----------APPQTLPLPVAHAALLPLT-AAGEAAPKTPPPAAKASA 99
Cdd:NF037978    3 GRMYRIPGYLLVVYALLLIALGWFGHQQWRSPsepiappaarPAPQPAAAPVAHAALVPLQqTSAATPDAPVQAAPLKSA 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1195228146 100 PAAPEVDSDTLPPLRYSAHVYASLPEKRSIVLNGKAWTEGDSPLPNLVVEQIQQDVTIFSFNGTTFTLAALEDWPG 175
Cdd:NF037978   83 LAAPTVDRGELPPLAYSAHVYTSDPEKRSIVLNGERYREGDSPLPGLVIEQIQQDMTIFSFNGETFTLAALQDWPG 158
T2SSB pfam16537
Type II secretion system protein B; This is the B protein from some operons of bacterial ...
 110-169 1.39e-21

Type II secretion system protein B; This is the B protein from some operons of bacterial secretion systems of type II. The exact function of the B protein is not known, though in the case of Vibrio cholerae there is a fusion protein between proteins A and B that includes an AAA domain, a PG_binding domains well as this domain at the C-terminus. Many of the other species have no A or B domain genes in this operon. The type II secretion pathway is conserved in Gram-negative bacteria that are prevalent in bacterial pathogens of plants (Pseudomonas fluorescens, Erwinia or Xanthomonas species), animals (Aeromonas hydrophila) and humans (Klebsiella oxytoca, Pseudomonas aeruginosa, Vibrio cholerae or Legionella pneumophila). Typical type II secretion systems (T2SSs) are encoded by a set of 12 to 16 gsp (general secretion pathway) genes organized into large operons including the conserved 'core' genes denoted C to O and in some bacterial species, as indicated above, extra gsp genes such as gspAB, gspN or gspS. A different nomenclature is used for Pseudomonas T2SSs, so the B gene is referred to as the P protein.


Pssm-ID: 435407  Cd Length: 60  Bit Score: 83.00  E-value: 1.39e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195228146 110 LPPLRYSAHVYASLPEKRSIVLNGKAWTEGDSPLPNLVVEQIQQDVTIFSFNGTTFTLAA 169
Cdd:pfam16537   1 LPALAYSAHVYSSNPANRWVIINGQELREGDTIAPGLTLEEIRPDGVVLRFDGQRFRLPA 60
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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