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Conserved domains on  [gi|1193113960|gb|OTQ80663|]
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HPr family phosphocarrier protein [Gilliamella sp. N-W3]

Protein Classification

HPr family phosphocarrier protein( domain architecture ID 10788234)

HPr family phosphocarrier protein is part of a phosphoenolpyruvate-dependent phosphotransferase (PTS)-like system that catalyzes the phosphorylation of incoming substrates with their concomitant translocation across the cell membrane

CATH:  3.30.1340.10
Gene Ontology:  GO:0008982
PubMed:  12405346
SCOP:  4001693
TCDB:  8.A.8

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PtsH COG1925
HPr or related phosphotransfer protein [Signal transduction mechanisms, Carbohydrate transport ...
 1-87 4.49e-37

HPr or related phosphotransfer protein [Signal transduction mechanisms, Carbohydrate transport and metabolism];


:

Pssm-ID: 441528 [Multi-domain]  Cd Length: 88  Bit Score: 119.44  E-value: 4.49e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1193113960  1 MLKEQMVVKNATGLHARPVTTLVKLAGRYKSSIELVYNDKTIKLKSMMGLLGAGVKGGSTVEIICDGEDEKAAMDEIREL 80
Cdd:COG1925    1 MLEREVTIVNKLGLHARPAAKLVQLASKFDSEITVEKGGKEVNAKSIMGLMSLGAKKGDEVTITAEGPDAEEALDALAAL 80


                 ....*..
gi 1193113960 81 FATGFGE 87
Cdd:COG1925   81 IESGFGE 87
 
Name Accession Description Interval E-value
PtsH COG1925
HPr or related phosphotransfer protein [Signal transduction mechanisms, Carbohydrate transport ...
 1-87 4.49e-37

HPr or related phosphotransfer protein [Signal transduction mechanisms, Carbohydrate transport and metabolism];


Pssm-ID: 441528 [Multi-domain]  Cd Length: 88  Bit Score: 119.44  E-value: 4.49e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1193113960  1 MLKEQMVVKNATGLHARPVTTLVKLAGRYKSSIELVYNDKTIKLKSMMGLLGAGVKGGSTVEIICDGEDEKAAMDEIREL 80
Cdd:COG1925    1 MLEREVTIVNKLGLHARPAAKLVQLASKFDSEITVEKGGKEVNAKSIMGLMSLGAKKGDEVTITAEGPDAEEALDALAAL 80


                 ....*..
gi 1193113960 81 FATGFGE 87
Cdd:COG1925   81 IESGFGE 87
PTS-HPr pfam00381
PTS HPr component phosphorylation site;
5-82 3.75e-33

PTS HPr component phosphorylation site;


Pssm-ID: 459792 [Multi-domain]  Cd Length: 79  Bit Score: 109.01  E-value: 3.75e-33
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1193113960  5 QMVVKNATGLHARPVTTLVKLAGRYKSSIELVYNDKTIKLKSMMGLLGAGVKGGSTVEIICDGEDEKAAMDEIRELFA 82
Cdd:pfam00381  2 TVTITNPLGLHARPAALLVQLASKFDSDITLEKGGKKVNAKSIMGLMSLGAKQGDEITISAEGEDEEEALEALAALLE 79
PTS-HPr_like cd00367
Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of ...
 7-81 4.15e-28

Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate is transferred to HPr by enzyme I (EI). Phospho-HPr then transfers the phosphoryl group to one of several sugar-specific phosphoprotein intermediates. The conserved histidine in the N-terminus of HPr serves as an acceptor for the phosphoryl group of EI. In addition to the phosphotransferase proteins HPr and E1, this family also includes the closely related Carbon Catabolite Repressor (CCR) proteins which use the same phosphorylation mechanism and interact with transcriptional regulators to control expression of genes coding for utilization of less favored carbon sources.


Pssm-ID: 238217 [Multi-domain]  Cd Length: 77  Bit Score: 96.42  E-value: 4.15e-28
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1193113960  7 VVKNATGLHARPVTTLVKLAGRYKSSIELVYNDKTIKLKSMMGLLGAGVKGGSTVEIICDGEDEKAAMDEIRELF 81
Cdd:cd00367    3 TITNPLGLHARPAALLVQLASKFKSDITLRKGGRKANAKSILGLMSLGAKQGDEITLSAEGEDAEEALEALAELL 77
PTS_HPr_family TIGR01003
Phosphotransferase System HPr (HPr) Family; The HPr family are bacterial proteins (or domains ...
 1-82 7.21e-26

Phosphotransferase System HPr (HPr) Family; The HPr family are bacterial proteins (or domains of proteins) which function in phosphoryl transfer system (PTS) systems. They include energy-coupling components which catalyze sugar uptake via a group translocation mechanism. The functions of most of these proteins are not known, but they presumably function in PTS-related regulatory capacities. All seed members are stand-alone HPr proteins, although the model also recognizes HPr domains of PTS fusion proteins. This family includes the related NPr protein. [Signal transduction, PTS]


Pssm-ID: 273389 [Multi-domain]  Cd Length: 82  Bit Score: 90.79  E-value: 7.21e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1193113960  1 MLKEQMVVKNATGLHARPVTTLVKLAGRYKSSIELVYNDKTIKLKSMMGLLGAGVKGGSTVEIICDGEDEKAAMDEIREL 80
Cdd:TIGR01003  1 MLSKEVTIINKVGLHARPAAILVKLASGFDSEITLTKNGKEVNAKSIMGIMMLGAGQGTEVTVSADGEDEAEALEALAKL 80


                 ..
gi 1193113960 81 FA 82
Cdd:TIGR01003 81 FE 82
PRK13780 PRK13780
phosphocarrier protein HPr; Provisional
 1-87 1.98e-21

phosphocarrier protein HPr; Provisional


Pssm-ID: 237503 [Multi-domain]  Cd Length: 88  Bit Score: 79.74  E-value: 1.98e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1193113960  1 MLKEQMVVKNATGLHARPVTTLVKLAGRYKSSIELVYNDKTIKLKSMMGLLGAGVKGGSTVEIICDGEDEKAAMDEIREL 80
Cdd:PRK13780   1 MASKDFHITAETGIHARPATLLVQTASKFDSDITLEYNGKSVNLKSIMGVMSLGVGQGADITISAEGADAADAIAAIEET 80


                 ....*...
gi 1193113960 81 FAT-GFGE 87
Cdd:PRK13780  81 MKKeGLAE 88
PTS-HPr_Halo NF041319
phosphocarrier protein HPr;
7-83 3.11e-13

phosphocarrier protein HPr;


Pssm-ID: 469216 [Multi-domain]  Cd Length: 87  Bit Score: 59.23  E-value: 3.11e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1193113960  7 VVKNAtGLHARPVTTLVKLAGRYKSSIEL---VYNDKTIKLKSMMGLLGAGVKGGSTVEIICDGEDEKAAMDEIRELFAT 83
Cdd:NF041319   7 VVPEA-GLHARPASKFVETANEFDAEVTVgraDDDGDLVNAASMLAVTGLGVRHGEDVRLVAEGDDAEAALDALEAVLST 85
 
Name Accession Description Interval E-value
PtsH COG1925
HPr or related phosphotransfer protein [Signal transduction mechanisms, Carbohydrate transport ...
 1-87 4.49e-37

HPr or related phosphotransfer protein [Signal transduction mechanisms, Carbohydrate transport and metabolism];


Pssm-ID: 441528 [Multi-domain]  Cd Length: 88  Bit Score: 119.44  E-value: 4.49e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1193113960  1 MLKEQMVVKNATGLHARPVTTLVKLAGRYKSSIELVYNDKTIKLKSMMGLLGAGVKGGSTVEIICDGEDEKAAMDEIREL 80
Cdd:COG1925    1 MLEREVTIVNKLGLHARPAAKLVQLASKFDSEITVEKGGKEVNAKSIMGLMSLGAKKGDEVTITAEGPDAEEALDALAAL 80


                 ....*..
gi 1193113960 81 FATGFGE 87
Cdd:COG1925   81 IESGFGE 87
PTS-HPr pfam00381
PTS HPr component phosphorylation site;
5-82 3.75e-33

PTS HPr component phosphorylation site;


Pssm-ID: 459792 [Multi-domain]  Cd Length: 79  Bit Score: 109.01  E-value: 3.75e-33
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1193113960  5 QMVVKNATGLHARPVTTLVKLAGRYKSSIELVYNDKTIKLKSMMGLLGAGVKGGSTVEIICDGEDEKAAMDEIRELFA 82
Cdd:pfam00381  2 TVTITNPLGLHARPAALLVQLASKFDSDITLEKGGKKVNAKSIMGLMSLGAKQGDEITISAEGEDEEEALEALAALLE 79
PTS-HPr_like cd00367
Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of ...
 7-81 4.15e-28

Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate is transferred to HPr by enzyme I (EI). Phospho-HPr then transfers the phosphoryl group to one of several sugar-specific phosphoprotein intermediates. The conserved histidine in the N-terminus of HPr serves as an acceptor for the phosphoryl group of EI. In addition to the phosphotransferase proteins HPr and E1, this family also includes the closely related Carbon Catabolite Repressor (CCR) proteins which use the same phosphorylation mechanism and interact with transcriptional regulators to control expression of genes coding for utilization of less favored carbon sources.


Pssm-ID: 238217 [Multi-domain]  Cd Length: 77  Bit Score: 96.42  E-value: 4.15e-28
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1193113960  7 VVKNATGLHARPVTTLVKLAGRYKSSIELVYNDKTIKLKSMMGLLGAGVKGGSTVEIICDGEDEKAAMDEIRELF 81
Cdd:cd00367    3 TITNPLGLHARPAALLVQLASKFKSDITLRKGGRKANAKSILGLMSLGAKQGDEITLSAEGEDAEEALEALAELL 77
PTS_HPr_family TIGR01003
Phosphotransferase System HPr (HPr) Family; The HPr family are bacterial proteins (or domains ...
 1-82 7.21e-26

Phosphotransferase System HPr (HPr) Family; The HPr family are bacterial proteins (or domains of proteins) which function in phosphoryl transfer system (PTS) systems. They include energy-coupling components which catalyze sugar uptake via a group translocation mechanism. The functions of most of these proteins are not known, but they presumably function in PTS-related regulatory capacities. All seed members are stand-alone HPr proteins, although the model also recognizes HPr domains of PTS fusion proteins. This family includes the related NPr protein. [Signal transduction, PTS]


Pssm-ID: 273389 [Multi-domain]  Cd Length: 82  Bit Score: 90.79  E-value: 7.21e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1193113960  1 MLKEQMVVKNATGLHARPVTTLVKLAGRYKSSIELVYNDKTIKLKSMMGLLGAGVKGGSTVEIICDGEDEKAAMDEIREL 80
Cdd:TIGR01003  1 MLSKEVTIINKVGLHARPAAILVKLASGFDSEITLTKNGKEVNAKSIMGIMMLGAGQGTEVTVSADGEDEAEALEALAKL 80


                 ..
gi 1193113960 81 FA 82
Cdd:TIGR01003 81 FE 82
PRK13780 PRK13780
phosphocarrier protein HPr; Provisional
 1-87 1.98e-21

phosphocarrier protein HPr; Provisional


Pssm-ID: 237503 [Multi-domain]  Cd Length: 88  Bit Score: 79.74  E-value: 1.98e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1193113960  1 MLKEQMVVKNATGLHARPVTTLVKLAGRYKSSIELVYNDKTIKLKSMMGLLGAGVKGGSTVEIICDGEDEKAAMDEIREL 80
Cdd:PRK13780   1 MASKDFHITAETGIHARPATLLVQTASKFDSDITLEYNGKSVNLKSIMGVMSLGVGQGADITISAEGADAADAIAAIEET 80


                 ....*...
gi 1193113960 81 FAT-GFGE 87
Cdd:PRK13780  81 MKKeGLAE 88
PRK13782 PRK13782
HPr family phosphocarrier protein;
1-77 1.43e-16

HPr family phosphocarrier protein;


Pssm-ID: 172320 [Multi-domain]  Cd Length: 82  Bit Score: 67.50  E-value: 1.43e-16
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1193113960  1 MLKEQMVVKNATGLHARPVTTLVKLAGRYKSSIELVYNDKTIKLKSMMGLLGAGVKGGSTVEIICDGEDEKAAMDEI 77
Cdd:PRK13782   1 MVQKRVEVSLKTGLQARPAALFVQEANRFHADIFIEKDGKKVNAKSIMGLMSLAIGTGSMITIITEGSDEEEALEAL 77
PRK11109 PRK11109
fused PTS fructose transporter subunit IIA/HPr protein;
7-87 3.36e-14

fused PTS fructose transporter subunit IIA/HPr protein;


Pssm-ID: 236849 [Multi-domain]  Cd Length: 375  Bit Score: 65.74  E-value: 3.36e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1193113960   7 VVKNATGLHARPVTTLVKLAGRYKSSIELVYND---KTIKLKSMMGLLGAGVKGGSTVEIICDGEDEKAAMDEIRELFAT 83
Cdd:PRK11109  291 VIRNEHGLHARPGAMLVNTIKQFNSEITVTNLDgtgKPANGRSLMKVVALGVKKGHRLRFTAQGEDAEQALKAIGEAIAA 370


                  ....
gi 1193113960  84 GFGE 87
Cdd:PRK11109  371 GLGE 374
PTS-HPr_Halo NF041319
phosphocarrier protein HPr;
7-83 3.11e-13

phosphocarrier protein HPr;


Pssm-ID: 469216 [Multi-domain]  Cd Length: 87  Bit Score: 59.23  E-value: 3.11e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1193113960  7 VVKNAtGLHARPVTTLVKLAGRYKSSIEL---VYNDKTIKLKSMMGLLGAGVKGGSTVEIICDGEDEKAAMDEIRELFAT 83
Cdd:NF041319   7 VVPEA-GLHARPASKFVETANEFDAEVTVgraDDDGDLVNAASMLAVTGLGVRHGEDVRLVAEGDDAEAALDALEAVLST 85
PRK10850 PRK10850
phosphocarrier protein Hpr;
1-82 1.20e-12

phosphocarrier protein Hpr;


Pssm-ID: 182777 [Multi-domain]  Cd Length: 85  Bit Score: 57.45  E-value: 1.20e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1193113960  1 MLKEQMVVKNATGLHARPVTTLVKLAGRYKSSIELVYNDKTIKLKSMMGLLGAGVKGGSTVEIICDGEDEKAAMDEIREL 80
Cdd:PRK10850   1 MFQQEVTITAPNGLHTRPAAQFVKEAKGFTSEITVTSNGKSASAKSLFKLQTLGLTQGTVVTISAEGEDEQKAVEHLVKL 80


                 ..
gi 1193113960 81 FA 82
Cdd:PRK10850  81 MA 82
PRK11377 PRK11377
dihydroxyacetone kinase subunit M; Provisional
 7-87 6.75e-12

dihydroxyacetone kinase subunit M; Provisional


Pssm-ID: 183108 [Multi-domain]  Cd Length: 473  Bit Score: 59.38  E-value: 6.75e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1193113960   7 VVKNATGLHARPVTTLVKLAGRYKSSIELVYNDKTIKLKSMMGLLGAGVKGGSTVEIICDGEDEKAAMDEIRELFATGFG 86
Cdd:PRK11377  161 VIKNRNGLHVRPASRLVYTLSTFNADMLLEKNGKCVTPESLNQIALLQVRYNDTLRLIAKGPEAEEALIAFRQLAEDNFG 240


                  .
gi 1193113960  87 E 87
Cdd:PRK11377  241 E 241
PRK13779 PRK13779
bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional
 7-87 2.06e-11

bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional


Pssm-ID: 237502 [Multi-domain]  Cd Length: 503  Bit Score: 57.96  E-value: 2.06e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1193113960   7 VVKNATGLHARPVTTLVKLAGRYKSSI---ELVYNDKTIKLKSMMGLLGAGVKGGSTVEIICDGEDEKAAMDEIRELFAT 83
Cdd:PRK13779  420 VIKNEHGLHARPSAVLVNEVKKYNASVavqNLDRNTQLVSAKSLMKIVALGVVKGHRLRFVATGEEAQQAIDGIGAAIAA 499


                  ....
gi 1193113960  84 GFGE 87
Cdd:PRK13779  500 GLGE 503
PRK13779 PRK13779
bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional
 8-87 8.83e-11

bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional


Pssm-ID: 237502 [Multi-domain]  Cd Length: 503  Bit Score: 56.04  E-value: 8.83e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1193113960   8 VKNATGLHARPVTTLVKLAGRYKSSI---ELVYNDKTIKLKSMMGLLGAGVKGGSTVEIICDGEDEKAAMDEIRELFATG 84
Cdd:PRK13779  297 IRNEHGLHARPSANLVNEVKKFTAKItveNLTRGSAPVSAKSLMKIVALGVTQGHRLRFVAEGEDAQQAIEALAKAIAEG 376


                  ...
gi 1193113960  85 FGE 87
Cdd:PRK13779  377 LGE 379
PRK10897 PRK10897
PTS phosphocarrier protein NPr;
2-87 4.88e-08

PTS phosphocarrier protein NPr;


Pssm-ID: 182819 [Multi-domain]  Cd Length: 90  Bit Score: 45.97  E-value: 4.88e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1193113960  2 LKEQMVVKNATGLHARPVTTLVKLAGRYKSSIeLVYNDKTIKLK--SMMGLLGAGVKGGSTVEIICDGEDEKAAMDEIRE 79
Cdd:PRK10897   3 VKQTVEIKNKLGMHARPAMKLFELVQGFDAEV-LLRNDEGTEAEanSVIALLMLDSAKGRQIEVEATGPQEEEALAAVIA 81


                 ....*...
gi 1193113960 80 LFATGFGE 87
Cdd:PRK10897  82 LFNSGFDE 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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