|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
1-433 |
0e+00 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 844.27 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 1 MKKLFVQFYLLLFVCFLVMTLLVGLVYKFTAERAGRQSLDDLMKSSLYLMRSELREIPPREWGKTLKEMDLNLSFDLRVE 80
Cdd:PRK10604 1 MRKLFIQFYLLLFVCFLVMTLLVGLVYKFTAERAGRQSLDDLMKSSLYLMRSELREIPPRDWGKTLKEMDLNLSFDLRIE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 81 PLNHYKLDAATTQRLREGDIVALDDQYTFIQRIPRSHYVLAVGPVPYLYFLHQMRLLDIALMALIAFSLAFPVFIWMRPH 160
Cdd:PRK10604 81 PLSKYHLDPASQQRLREGEIVALDDQYTFLQRIPRSHYVLAVGPVPYLYYLHQMRLLDIALLALIGLSLAFPVFLWMRPH 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 161 WQEMLRLESAAQRFGEGHLTERLHFDNGSSFERLGVAFNQMADNINALIASKKQLIDGIAHELRTPLVRLRYRLEMSENL 240
Cdd:PRK10604 161 WQDMLKLEAAAQRLGDGHLAERIHFDEGSSLERLGVAFNQMADNINALIASKKQLIDGIAHELRTPLVRLRYRLEMSDNL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 241 TPPESQALNRDIGQLEALIEELLTYARLDRPQNELMLTEPDLPAWLLAHLQDVQSVTPERAVNLLTSVIGDYGALDMRLM 320
Cdd:PRK10604 241 SAAESQALNRDIGQLEALIEELLTYARLDRPQNELHLSEPDLPAWLSTHLADIQAVTPEKTVRLDTPHQGDYGALDMRLM 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 321 SRVLDNLLNNALRYSRTTVQVSLLLDGSQATLIVEDDGPGIEADARERIFEPFVRLDPSRDRATGGCGLGLAIVHSIALA 400
Cdd:PRK10604 321 ERVLDNLLNNALRYAHSRVRVSLLLDGNQACLIVEDDGPGIPPEERERVFEPFVRLDPSRDRATGGCGLGLAIVHSIALA 400
|
410 420 430
....*....|....*....|....*....|...
gi 1185626239 401 MGGSVVCDESELGGAKFSFRWPVWHAMPDMTAA 433
Cdd:PRK10604 401 MGGSVNCDESELGGARFSFSWPVWHNLPQFTSA 433
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
320-423 |
6.42e-60 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 190.33 E-value: 6.42e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 320 MSRVLDNLLNNALRYSRTTVQVSLLLDGSQATLIVEDDGPGIEADARERIFEPFVRLDPSRDRATGGCGLGLAIVHSIAL 399
Cdd:cd16939 1 MARALDNLLRNALRYAHRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVHRVAL 80
|
90 100
....*....|....*....|....
gi 1185626239 400 AMGGSVVCDESELGGAKFSFRWPV 423
Cdd:cd16939 81 WHGGHVECDDSELGGACFRLTWPR 104
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
87-426 |
2.86e-52 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 180.13 E-value: 2.86e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 87 LDAATTQRLREGDIVALDDQYTFIQRIPRSHYVLAVGPVPYLYFLHQMRLLDIALMALIAFSLAFPVFIWMRPHWQEMLR 166
Cdd:COG5002 40 LLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLL 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 167 LESAAQRFGEGHLTERLHFDNGSSFERLGVAFNQMADNINALIASKKQLIDGIAHELRTPLVRLRYRLEM--SENLTPPE 244
Cdd:COG5002 120 LLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERLEQMRREFVANVSHELRTPLTSIRGYLELllDGAADDPE 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 245 SQA-----LNRDIGQLEALIEELLTYARLDRPQNELMLTEPDLPAWLLAHLQDVQSVTPERAVNLLTSVIGDYGAL--DM 317
Cdd:COG5002 200 ERReyleiILEEAERLSRLVNDLLDLSRLESGELKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLPEDPLLVlgDP 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 318 RLMSRVLDNLLNNALRYSR--TTVQVSLLLDGSQATLIVEDDGPGIEADARERIFEPFVRLDPSRDRATGGCGLGLAIVH 395
Cdd:COG5002 280 DRLEQVLTNLLDNAIKYTPegGTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRSRETGGTGLGLAIVK 359
|
330 340 350
....*....|....*....|....*....|..
gi 1185626239 396 SIALAMGGSVVCdESELG-GAKFSFRWPVWHA 426
Cdd:COG5002 360 HIVEAHGGRIWV-ESEPGkGTTFTITLPLARE 390
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
100-423 |
1.84e-51 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 176.25 E-value: 1.84e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 100 IVALDDQYTFIQRIPRSHYVLAVGPVPYLYFLHQMRLLDIALMALIAFSLAFPVFIWMRPHWQEMLRLESAAQRFGEGHL 179
Cdd:COG0642 1 LLLLLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 180 TERLHFDNGSSFERLGVAFNQMADNINAliaSKKQLIDGIAHELRTPLVRLRYRLEMSENLTPPES----QALNRDIGQL 255
Cdd:COG0642 81 LLLLLLLLLLLLLLLLLALLLLLEEANE---AKSRFLANVSHELRTPLTAIRGYLELLLEELDEEQreylETILRSADRL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 256 EALIEELLTYARLDRPQNELMLTEPDLPAWLLAHLQDVQSVTPERAVNLLTSVIGDYGAL--DMRLMSRVLDNLLNNALR 333
Cdd:COG0642 158 LRLINDLLDLSRLEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLPTVrgDPDRLRQVLLNLLSNAIK 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 334 YSR--TTVQVSLLLDGSQATLIVEDDGPGIEADARERIFEPFVRLDPSrdRATGGCGLGLAIVHSIALAMGGSVVCDESE 411
Cdd:COG0642 238 YTPegGTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPS--RRGGGTGLGLAIVKRIVELHGGTIEVESEP 315
|
330
....*....|..
gi 1185626239 412 LGGAKFSFRWPV 423
Cdd:COG0642 316 GKGTTFTVTLPL 327
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
197-426 |
2.08e-49 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 167.78 E-value: 2.08e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 197 AFNQMADNINALIASKKQLIDGIAHELRTPLVRLRYRLEM---SENLTPPESQAL----NRDIGQLEALIEELLTYARLD 269
Cdd:COG2205 1 ELEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELlldEEDLSPEERRELleiiRESAERLLRLIEDLLDLSRLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 270 RPQNELMLTEPDLPAWLLAHLQDVQSVTPERAVNLLTSVIGD--YGALDMRLMSRVLDNLLNNALRYSR--TTVQVSLLL 345
Cdd:COG2205 81 SGKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPElpLVYADPELLEQVLANLLDNAIKYSPpgGTITISARR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 346 DGSQATLIVEDDGPGIEADARERIFEPFVRLDpsRDRATGGCGLGLAIVHSIALAMGGSVVCDESELGGAKFSFRWPVWH 425
Cdd:COG2205 161 EGDGVRISVSDNGPGIPEEELERIFERFYRGD--NSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPLAE 238
|
.
gi 1185626239 426 A 426
Cdd:COG2205 239 S 239
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
122-426 |
8.50e-42 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 153.55 E-value: 8.50e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 122 VGPVP--------YLYFLHQM---------RLLDIALMALIAFSLA-FPVFIWMRphW---QEMLRLESAAQRFGEGHLT 180
Cdd:PRK09470 133 VGPFSvrdgednyQLYLIRPAnspqsdfinLLFDRPLLLLLVTMLVsTPLLLWLA--WslaKPARKLKNAADEVAQGNLR 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 181 ERLHFDNGSS-FERLGVAFNQMADNINALIASKKQLIDGIAHELRTPLVRL-------RYRLEMSENLTPPESQALnrdi 252
Cdd:PRK09470 211 QHPELETGPQeFRQAGASFNQMVTALERMMTSQQRLLSDISHELRTPLTRLqlatallRRRQGESKELERIETEAQ---- 286
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 253 gQLEALIEELLTyarLDRPQNELMLTEPDLPAWLLAH--LQDVQ------------SVTPERavnllTSVIGDYGALdmr 318
Cdd:PRK09470 287 -RLDSMINDLLV---LSRNQQKNHLERETFKANSLWSevLEDAKfeaeqmgksltvSAPPGP-----WPINGNPNAL--- 354
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 319 lMSrVLDNLLNNALRYSRTTVQVSLLLDGSQATLIVEDDGPGIEADARERIFEPFVRLDPSRDRATGGCGLGLAIVHSIA 398
Cdd:PRK09470 355 -AS-ALENIVRNALRYSHTKIEVAFSVDKDGLTITVDDDGPGVPEEEREQIFRPFYRVDEARDRESGGTGLGLAIVENAI 432
|
330 340
....*....|....*....|....*...
gi 1185626239 399 LAMGGSVVCDESELGGAKFSFRWPVWHA 426
Cdd:PRK09470 433 QQHRGWVKAEDSPLGGLRLTIWLPLYKR 460
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
141-423 |
4.94e-39 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 145.44 E-value: 4.94e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 141 LMALIAFSLAFP-VFIWM--RPhwqeMLRLESAAQRFGEGHLTERLHfDNGSSfERLGV--AFNQMADNINALIASKKQL 215
Cdd:PRK09467 159 TLAIGLLSVAGGwLFIRIqnRP----LVALEHAALQVGKGEIPPPLR-EYGAS-EVRSVtrAFNQMAAGIKQLEDDRTLL 232
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 216 IDGIAHELRTPLVRLRYRLEMsenlTPPESQAL----NRDIGQLEALIEELLTYARLDrpqNELMLTEPDLPAWLlahlQ 291
Cdd:PRK09467 233 MAGVSHDLRTPLTRIRLATEM----MSEEDGYLaesiNKDIEECNAIIEQFIDYLRTG---QEMPMEMADLNALL----G 301
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 292 DVQSVTPERAVNLLTSVIGDYGALDMRLMS--RVLDNLLNNALRYSRTTVQVSLLLDGSQATLIVEDDGPGIEADARERI 369
Cdd:PRK09467 302 EVIAAESGYEREIETALQPGPIEVPMNPIAikRALANLVVNAARYGNGWIKVSSGTEGKRAWFQVEDDGPGIPPEQLKHL 381
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 1185626239 370 FEPFVRLDpsRDRATGGCGLGLAIVHSIALAMGGSVVCDESELGGAKFSFRWPV 423
Cdd:PRK09467 382 FQPFTRGD--SARGSSGTGLGLAIVKRIVDQHNGKVELGNSEEGGLSARAWLPL 433
|
|
| BaeS_SmeS |
NF012163 |
sensor histidine kinase efflux regulator BaeS; |
129-422 |
6.55e-35 |
|
sensor histidine kinase efflux regulator BaeS;
Pssm-ID: 411086 [Multi-domain] Cd Length: 457 Bit Score: 134.57 E-value: 6.55e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 129 YFLHQMR--LLDIALMALIAFSLAFPVFIWMRphwQEMLRLESAAQRFGEGHLTERLHFDNGSSFERLGVAFNQMADNIN 206
Cdd:NF012163 158 FDSQQKRasWLIVALALLLAALAAFLLARGLL---APVKRLVEATHRLAAGDYTTRVTPTSNDELGKLAQDFNQLASTLE 234
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 207 ALIASKKQLIDGIAHELRTPLVRLRYRLEMSEN----LTPPESQALNRDIGQLEALIEELLTYARLDRPQNELMLTEPDL 282
Cdd:NF012163 235 KNEQMRRDFMADISHELRTPLAVLRAELEAIQDgirkFTPESLDSLQAEVGTLTKLVDDLHDLSMSDEGALAYQKASVDL 314
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 283 PAWLLAHLQDVQSVTPERAVNLLTSVIGDYGAL-DMRLMSRVLDNLLNNALRYSRT--TVQVSLLLDGSQATLIVEDDGP 359
Cdd:NF012163 315 VPLLEVEGGAFRERFASAGLELEVSLPDSSLVFgDRDRLMQLFNNLLENSLRYTDSggSLHISASQRPKEVTLTVADSAP 394
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1185626239 360 GIEADARERIFEPFVRLDPSRDRATGGCGLGLAIVHSIALAMGGSVVCDESELGGAKFSFRWP 422
Cdd:NF012163 395 GVSDEQLARLFERFYRVEVSRNRASGGSGLGLAISLNIVQAHGGTLHAAHSPLGGLRIVVTLP 457
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
135-428 |
9.74e-33 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 128.16 E-value: 9.74e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 135 RLLDIALMALI---------AFSLAFPVFIWMRPHWQEMLRLESaaqrfgEGHLTERLHfdnGSSFERLG--VAFnqmaD 203
Cdd:COG5000 121 RLLGIPLEELIgkpleellpELDLAELLREALERGWQEEIELTR------DGRRTLLVR---ASPLRDDGyvIVF----D 187
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 204 NINALIASKK-----QLIDGIAHELRTPLV-------RLRYRLEMSENLTPPE----SQALNRDIGQLEALIEELLTYAR 267
Cdd:COG5000 188 DITELLRAERlaawgELARRIAHEIKNPLTpiqlsaeRLRRKLADKLEEDREDleraLDTIIRQVDRLKRIVDEFLDFAR 267
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 268 LDRPQNELMltepDLPAWL--LAHLQDVQSVTPERAVNLLTSVIGDYGALDMRLMSRVLDNLLNNALR--YSRTTVQVSL 343
Cdd:COG5000 268 LPEPQLEPV----DLNELLreVLALYEPALKEKDIRLELDLDPDLPEVLADRDQLEQVLINLLKNAIEaiEEGGEIEVST 343
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 344 LLDGSQATLIVEDDGPGIEADARERIFEPFVrldpsrdraT---GGCGLGLAIVHSIALAMGGSVVCDESELGGAKFSFR 420
Cdd:COG5000 344 RREDGRVRIEVSDNGPGIPEEVLERIFEPFF---------TtkpKGTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIR 414
|
....*...
gi 1185626239 421 WPVWHAMP 428
Cdd:COG5000 415 LPLAEEAE 422
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
320-421 |
3.38e-32 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 117.70 E-value: 3.38e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 320 MSRVLDNLLNNALRYS--RTTVQVSLLLDGSQATLIVEDDGPGIEADARERIFEPFVRLDPSRDRatGGCGLGLAIVHSI 397
Cdd:cd00075 1 LEQVLSNLLDNALKYSppGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSREG--GGTGLGLAIVRRI 78
|
90 100
....*....|....*....|....
gi 1185626239 398 ALAMGGSVVCDESELGGAKFSFRW 421
Cdd:cd00075 79 VEAHGGRITVESEPGGGTTFTVTL 102
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
316-423 |
1.19e-31 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 116.59 E-value: 1.19e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 316 DMRLMSRVLDNLLNNALRYS--RTTVQVSLLLDGSQATLIVEDDGPGIEADARERIFEPFVRLDPsRDRATGGCGLGLAI 393
Cdd:smart00387 2 DPDRLRQVLSNLLDNAIKYTpeGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDK-RSRKIGGTGLGLSI 80
|
90 100 110
....*....|....*....|....*....|
gi 1185626239 394 VHSIALAMGGSVVCDESELGGAKFSFRWPV 423
Cdd:smart00387 81 VKKLVELHGGEISVESEPGGGTTFTITLPL 110
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
38-422 |
7.28e-31 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 123.27 E-value: 7.28e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 38 SLDDLMKSSLYLMRSELREIPPREWGKTLKEMDLnlsfdlRVEPLNHYKLDAATTQRLREGDivalddqytfiqriPRSH 117
Cdd:TIGR01386 84 SILNPDGRLLFERAQGAALVPAVAANDALLELDQ------ADAKMTHYRSILRSVAALPGGK--------------GRKP 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 118 YVLAVGP--VPYLYFLHQMRLLDIALMALIAFSLAFPVFIWMRPHWQEMLRLESAAQRFGEGHLTERLHFDNGSS-FERL 194
Cdd:TIGR01386 144 VQITVALdiNAHTHLLDALRKWLILIAVLLVLLTALLGWWITRLGLEPLRRLSAVAARISPESLDQRLDPSRAPAeLREL 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 195 GVAFNQMADNINALIASKKQLIDGIAHELRTPLVRLRYRLEMSenLTPPESQALNRDIGQ--------LEALIEELLTYA 266
Cdd:TIGR01386 224 AQSFNAMLGRLEDAFQRLSQFSADLAHELRTPLTNLLGQTQVA--LSQPRTGEEYREVLEsnleelerLSRMVSDMLFLA 301
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 267 RLDRPQNELMLTEPDLPAWLLAHLQDVQSVTPERAVNLLTSVIGDYGAlDMRLMSRVLDNLLNNALRYS--RTTVQVSLL 344
Cdd:TIGR01386 302 RADNGQLALERVRLDLAAELAKVAEYFEPLAEERGVRIRVEGEGLVRG-DPQMFRRAISNLLSNALRHTpdGGTITVRIE 380
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1185626239 345 LDGSQATLIVEDDGPGIEADARERIFEPFVRLDPSRDRATGGCGLGLAIVHSIALAMGGSVVCdESELGGAKFSFRWP 422
Cdd:TIGR01386 381 RRSDEVRVSVSNPGPGIPPEHLSRLFDRFYRVDPARSNSGEGTGLGLAIVRSIMEAHGGRASA-ESPDGKTRFILRFP 457
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
320-422 |
3.23e-30 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 112.42 E-value: 3.23e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 320 MSRVLDNLLNNALRYSRTTVQVSLLLDGSQATLIVEDDGPGIEADARERIFEPFVRLDPSRDRATGGCGLGLAIVHSIAL 399
Cdd:cd16949 1 LARALENVLRNALRYSPSKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAERAIE 80
|
90 100
....*....|....*....|...
gi 1185626239 400 AMGGSVVCDESELGGAKFSFRWP 422
Cdd:cd16949 81 QHGGKIKASNRKPGGLRVRIWLP 103
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
219-423 |
3.40e-29 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 119.12 E-value: 3.40e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 219 IAHELRTPLVRLRY---RLEM--SENLTPPESQALNR---DIGQLEALIEELLTYARLDRPQNELMLTepDLPAWLLAHL 290
Cdd:COG4251 289 ASHDLREPLRKISGfsqLLEEdyGDKLDEEGREYLERirdAAERMQALIDDLLAYSRVGRQELEFEPV--DLNELLEEVL 366
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 291 QDVQSVTPERAVNL----LTSVIGDYgaldmRLMSRVLDNLLNNALRYSRT----TVQVSLLLDGSQATLIVEDDGPGIE 362
Cdd:COG4251 367 EDLEPRIEERGAEIevgpLPTVRGDP-----TLLRQVFQNLISNAIKYSRPgeppRIEIGAEREGGEWVFSVRDNGIGID 441
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1185626239 363 ADARERIFEPFVRLDPSRDRatGGCGLGLAIVHSIALAMGGSVVCdESELG-GAKFSFRWPV 423
Cdd:COG4251 442 PEYAEKIFEIFQRLHSRDEY--EGTGIGLAIVKKIVERHGGRIWV-ESEPGeGATFYFTLPK 500
|
|
| phoR_proteo |
TIGR02966 |
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ... |
219-420 |
4.13e-29 |
|
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]
Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 116.15 E-value: 4.13e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 219 IAHELRTPLVRLRYRLEMSENLTPPESQALNRDIGQ-------LEALIEELLTYARLDRPQNELMLTEPDLPAwLLAHLQ 291
Cdd:TIGR02966 121 VSHELRTPLTVLRGYLETLADGPDEDPEEWNRALEImleqsqrMQSLVEDLLTLSRLESAASPLEDEPVDMPA-LLDHLR 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 292 -DVQSVTPERAVNLLTSVIGD---YGALDmRLMSrVLDNLLNNALRYSR--TTVQVSLLLDGSQATLIVEDDGPGIEADA 365
Cdd:TIGR02966 200 dEAEALSQGKNHQITFEIDGGvdvLGDED-ELRS-AFSNLVSNAIKYTPegGTITVRWRRDGGGAEFSVTDTGIGIAPEH 277
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 1185626239 366 RERIFEPFVRLDPSRDRATGGCGLGLAIVHSIALAMGGSVVCdESELG-GAKFSFR 420
Cdd:TIGR02966 278 LPRLTERFYRVDKSRSRDTGGTGLGLAIVKHVLSRHHARLEI-ESELGkGSTFSFI 332
|
|
| MtrAB_MtrB |
NF040691 |
MtrAB system histidine kinase MtrB; |
139-393 |
6.64e-29 |
|
MtrAB system histidine kinase MtrB;
Pssm-ID: 468655 [Multi-domain] Cd Length: 507 Bit Score: 118.59 E-value: 6.64e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 139 IALMALIAFSLAFPVFIWMRphwqemlRLESAAQRFGEGHLTERLHFDNGSSFERLGVAFNQMADNINALIAS------- 211
Cdd:NF040691 198 VVLLGLIAWLVTRQVVAPVR-------SAARTAERFAAGDLSERMPVKGEDDLARLARSFNQMADSLQRQIRQleelsrl 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 212 KKQLIDGIAHELRTPLVRLRYRLEM----SENLTPPESQA---LNRDIGQLEALIEELLTYARLDRPQNELMLTEPDLPA 284
Cdd:NF040691 271 QQRFVSDVSHELRTPLTTIRMAADVihdsRDDFDPATARSaelLHTELDRFESLLSDLLEISRFDAGAAELDVEPVDLRP 350
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 285 WLLAHLQDVQSVTPERAVNLLTSVIGDYGALDM--RLMSRVLDNLLNNALRYSRTT-VQVSLLLDGSQATLIVEDDGPGI 361
Cdd:NF040691 351 LVRRVVDALRQLAERAGVELRVDAPGTPVVAEVdpRRVERVLRNLVVNAIEHGEGKpVVVTVAQDDTAVAVTVRDHGVGL 430
|
250 260 270
....*....|....*....|....*....|..
gi 1185626239 362 EADARERIFEPFVRLDPSRDRATGGCGLGLAI 393
Cdd:NF040691 431 KPGEVALVFDRFWRADPARARTTGGTGLGLAI 462
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
87-423 |
2.25e-27 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 111.81 E-value: 2.25e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 87 LDAATTQRLREGDIVALDDQYTFIQRIPRSHYVLAVGPVPYLYFLHQMRLLDIALMALIAFSLAFPVFIWMRPHWQEMLR 166
Cdd:COG4191 5 LLLLLLLLALLRALALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLLLGL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 167 LESAAQRFGEGHLTERLHFDNGSSFERLGVAFNQMADNINALIASKKQLID------------GIAHELRTPLVRLRYRL 234
Cdd:COG4191 85 LLLLLLEALLLLLLAALDAEENAELEELERDITELERAEEELRELQEQLVQseklaalgelaaGIAHEINNPLAAILGNA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 235 EMSENLT--PPESQALNRDIGQLE-------ALIEELLTYARLDRPQNELMltepDLPAWLLAHLQDVQSVTPERAVNL- 304
Cdd:COG4191 165 ELLRRRLedEPDPEELREALERILegaeraaEIVRSLRAFSRRDEEEREPV----DLNELIDEALELLRPRLKARGIEVe 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 305 ------LTSVIGDYGALdmrlmSRVLDNLLNNAL-----RYSRTtVQVSLLLDGSQATLIVEDDGPGIEADARERIFEPF 373
Cdd:COG4191 241 ldlppdLPPVLGDPGQL-----EQVLLNLLINAIdameeGEGGR-ITISTRREGDYVVISVRDNGPGIPPEVLERIFEPF 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1185626239 374 VrldpSRDRATGGCGLGLAIVHSIALAMGGSVVCDESELGGAKFSFRWPV 423
Cdd:COG4191 315 F----TTKPVGKGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLPL 360
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
316-422 |
7.52e-27 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 103.70 E-value: 7.52e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 316 DMRLMSRVLDNLLNNALRYSRT--TVQVSLLLDGSQATLIVEDDGPGIEADARERIFEPFVRLDPSRDRATGGCGLGLAI 393
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTggKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGLAI 80
|
90 100
....*....|....*....|....*....
gi 1185626239 394 VHSIALAMGGSVVCDESELGGAKFSFRWP 422
Cdd:cd16946 81 CHNIALAHGGTISAEHSPLGGLRLVLTLP 109
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
166-428 |
1.25e-25 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 108.57 E-value: 1.25e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 166 RLESAAQRFGEGHLTERLHFDNGSSFERLGVAFNQMADNINALIASKKQLIDGIAHELRTPLVRLRYRLEMSEN----LT 241
Cdd:PRK10549 194 RLVEGTHKLAAGDFTTRVTPTSRDELGRLAQDFNQLASTLEKNEQMRRDFMADISHELRTPLAVLRGELEAIQDgvrkFT 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 242 PPESQALNRDIGQLEALIEEL----------LTYARldRPQNELMLTEPDLPAW---LLAHLQDVQSVTPERAVnlltsV 308
Cdd:PRK10549 274 PESVASLQAEVGTLTKLVDDLhqlslsdegaLAYRK--TPVDLVPLLEVAGGAFrerFASRGLTLQLSLPDSAT-----V 346
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 309 IGDYGaldmRLMsRVLDNLLNNALRY--SRTTVQVSLLLDGSQATLIVEDDGPGIEADARERIFEPFVRLDPSRDRATGG 386
Cdd:PRK10549 347 FGDPD----RLM-QLFNNLLENSLRYtdSGGSLHISAEQRDKTLRLTFADSAPGVSDEQLQKLFERFYRTEGSRNRASGG 421
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 1185626239 387 CGLGLAIVHSIALAMGGSVVCDESELGGAKFSFRWPVWHAMP 428
Cdd:PRK10549 422 SGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPLERDLQ 463
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
316-423 |
1.44e-25 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 100.14 E-value: 1.44e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 316 DMRLMSRVLDNLLNNALRYSRTTVQVSLLLD-GSQATLIVEDDGPGIEADARERIFEPFVRLDpsrDRATGGCGLGLAIV 394
Cdd:pfam02518 2 DELRLRQVLSNLLDNALKHAAKAGEITVTLSeGGELTLTVEDNGIGIPPEDLPRIFEPFSTAD---KRGGGGTGLGLSIV 78
|
90 100
....*....|....*....|....*....
gi 1185626239 395 HSIALAMGGSVVCDESELGGAKFSFRWPV 423
Cdd:pfam02518 79 RKLVELLGGTITVESEPGGGTTVTLTLPL 107
|
|
| AdeS_HK |
NF012226 |
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component ... |
167-405 |
6.48e-25 |
|
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component regulatory system for the AdeABC efflux pump can confer adaptive resistance to certain antibiotics, including tigecycline.
Pssm-ID: 411090 [Multi-domain] Cd Length: 353 Bit Score: 104.69 E-value: 6.48e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 167 LESAAQRFGEGHLTERLHFDNGSSFE--RLGVAFNQMADNI-----NALIASKkqlidGIAHELRTPLVRLRYRLE-MSE 238
Cdd:NF012226 91 LADAAKKISQGDLSARAEDSQIHSAEisELMHNFNDMAQKLessvkNAQVWNA-----AIAHELRTPITILQGRLQgILD 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 239 NLTPPEsQALNRD-IGQLEA---LIEELLTYARLDRPQNELMLTEPDLPAWLLAHLQDVQSVTPERAVNLLTSVIGDYGA 314
Cdd:NF012226 166 GVFEPD-PALFKSlLNQVEGlshLVEDLRTLSLVENQQLRLNYESVDLKDSIEKVLKMFEDRLEQAQLTIVLNLTATPVF 244
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 315 LDMRLMSRVLDNLLNNALRYSRT-TVQVSLLLDGSQATLIVEDDGPGIEADARERIFEPFVRLDPSRDRATGGCGLGLAI 393
Cdd:NF012226 245 CDRRRIEQVLIALIDNAIRYANAgKLKISSSVIQDDWILQIEDEGPGIAEEYQQDLFNPFFRLEQSRNKEFGGTGLGLAV 324
|
250
....*....|..
gi 1185626239 394 VHSIALAMGGSV 405
Cdd:NF012226 325 VHAIVIAHKGSI 336
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
323-423 |
3.93e-24 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 96.02 E-value: 3.93e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 323 VLDNLLNNALRYSRT---TVQVSLLLDGSQATLI---VEDDGPGIEADARERIFEPFVRLDPSRDRATGGCGLGLAIVHS 396
Cdd:cd16922 4 ILLNLLGNAIKFTEEgevTLRVSLEEEEEDGVQLrfsVEDTGIGIPEEQQARLFEPFSQADSSTTRKYGGTGLGLAISKK 83
|
90 100
....*....|....*....|....*...
gi 1185626239 397 IALAMGGSVVCdESELG-GAKFSFRWPV 423
Cdd:cd16922 84 LVELMGGDISV-ESEPGqGSTFTFTLPL 110
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
219-422 |
7.35e-24 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 102.78 E-value: 7.35e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 219 IAHELRTPLVRLRYRLEMSENLT---PPESQALNRDIGQL---EALIEELLTYARLDRPQNELMLTEPDLPAWLLAHLQD 292
Cdd:PRK11006 211 VSHELRTPLTVLQGYLEMMQDQPlegALREKALHTMREQTqrmEGLVKQLLTLSKIEAAPTIDLNEKVDVPMMLRVLERE 290
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 293 VQSVTPER-----AVNLLTSVIGDygalDMRLMSRVlDNLLNNALRYSR--TTVQVSLLLDGSQATLIVEDDGPGIEADA 365
Cdd:PRK11006 291 AQTLSQGKhtitfEVDNSLKVFGN----EDQLRSAI-SNLVYNAVNHTPegTHITVRWQRVPQGAEFSVEDNGPGIAPEH 365
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 1185626239 366 RERIFEPFVRLDPSRDRATGGCGLGLAIV-HsiALAMGGSVVCDESELG-GAKFSFRWP 422
Cdd:PRK11006 366 IPRLTERFYRVDKARSRQTGGSGLGLAIVkH--ALSHHDSRLEIESEVGkGTRFSFVLP 422
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
186-398 |
1.53e-23 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 100.81 E-value: 1.53e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 186 DNGSSFERLGV--AFNQMADNINALIASKKQLIDGIAHELRTPLVRLRYRLEMSENLTPPESQALNRDIGQLEALIEELL 263
Cdd:PRK10755 109 IHSSTLEIEAVtsALNQLVSRLTSTLDQERLFTADVAHELRTPLAGIRLHLELLEKQHHIDVAPLIARLDQMMHTVEQLL 188
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 264 TYARLDRP------QNELMLTEPDLPAW----LLAHLQDVQSVTPERAVNLltSVIGDygALDMRLMSRvldNLLNNALR 333
Cdd:PRK10755 189 QLARAGQSfssghyQTVKLLEDVILPSQdelsEMLEQRQQTLLLPESAADI--TVQGD--ATLLRLLLR---NLVENAHR 261
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1185626239 334 YS--RTTVQVSLLLDGSQATLIVEDDGPGIEADARERIFEPFVRLdpsrDRATGGCGLGLAIVHSIA 398
Cdd:PRK10755 262 YSpeGSTITIKLSQEDGGAVLAVEDEGPGIDESKCGELSKAFVRM----DSRYGGIGLGLSIVSRIT 324
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
213-429 |
4.41e-23 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 99.54 E-value: 4.41e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 213 KQLIDGIAHELRTPLVRLRYRLE-MSENLTPPESQALNRDIGQ----LEALIEELLTYARLDRPQNELMltepDLPAwLL 287
Cdd:COG3852 136 GELAAGLAHEIRNPLTGIRGAAQlLERELPDDELREYTQLIIEeadrLNNLVDRLLSFSRPRPPEREPV----NLHE-VL 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 288 AHLQDVQSVTPERAVNLLTsvigDYGA------LDMRLMSRVLDNLLNNAL-------------RYSRTtVQVSLLLDGS 348
Cdd:COG3852 211 ERVLELLRAEAPKNIRIVR----DYDPslpevlGDPDQLIQVLLNLVRNAAeampeggtitirtRVERQ-VTLGGLRPRL 285
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 349 QATLIVEDDGPGIEADARERIFEPFVRldpSRDRATggcGLGLAIVHSIALAMGGSVVCdESELG-GAKFSFRWPVWHAM 427
Cdd:COG3852 286 YVRIEVIDNGPGIPEEILDRIFEPFFT---TKEKGT---GLGLAIVQKIVEQHGGTIEV-ESEPGkGTTFRIYLPLEQAE 358
|
..
gi 1185626239 428 PD 429
Cdd:COG3852 359 EE 360
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
320-414 |
5.10e-23 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 92.90 E-value: 5.10e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 320 MSRVLDNLLNNALRYSRTTVQVSLLLDGSQATLIVEDDGPGIEADARERIFEPFVRLDPSRDraTGGCGLGLAIVHSIAL 399
Cdd:cd16950 1 LKRVLSNLVDNALRYGGGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARG--TSGTGLGLAIVQRISD 78
|
90
....*....|....*
gi 1185626239 400 AMGGSVVCDESELGG 414
Cdd:cd16950 79 AHGGSLTLANRAGGG 93
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
209-424 |
1.10e-22 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 98.87 E-value: 1.10e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 209 IASKKQLIDGIAHELRTPL---------VRLRYRLEMSENLTPPESQALNRDIGQL---EALIEELLTYARLDRPQNELM 276
Cdd:PRK09303 148 LKFKDRVLAMLAHDLRTPLtaaslaletLELGQIDEDTELKPALIEQLQDQARRQLeeiERLITDLLEVGRTRWEALRFN 227
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 277 LTEPDLPAWLLAHLQDVQSVTPERAVNLLTSVIGD----YGalDMRLMSRVLDNLLNNALRYS------------RTT-- 338
Cdd:PRK09303 228 PQKLDLGSLCQEVILELEKRWLAKSLEIQTDIPSDlpsvYA--DQERIRQVLLNLLDNAIKYTpeggtitlsmlhRTTqk 305
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 339 VQVSllldgsqatliVEDDGPGIEADARERIFEPFVRLDpsRDRATGGCGLGLAIVHSIALAMGGSVVCDeSELG-GAKF 417
Cdd:PRK09303 306 VQVS-----------ICDTGPGIPEEEQERIFEDRVRLP--RDEGTEGYGIGLSVCRRIVRVHYGQIWVD-SEPGqGSCF 371
|
....*..
gi 1185626239 418 SFRWPVW 424
Cdd:PRK09303 372 HFTLPVY 378
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
323-418 |
6.45e-22 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 90.77 E-value: 6.45e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 323 VLDNLLNNALRYSRTTVQVSLLLDGSQATLIVEDDGPGIEADARERIFEPFVRLDPSRDratgGCGLGLAIVHSIALAMG 402
Cdd:cd16954 41 LLGNLLDNACKWCLEFVEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQRGQRLDEQRP----GQGLGLAIAKEIVEQYG 116
|
90
....*....|....*.
gi 1185626239 403 GSVVCDESELGGAKFS 418
Cdd:cd16954 117 GELSLSDSPLGGARFE 132
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
197-421 |
3.03e-21 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 95.49 E-value: 3.03e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 197 AFNQMADNINALIASKKQLIDGIAHELRTPLVRLRYRLEMSEnLTPPESQALNRDIGQLEA-------LIEELLTYARLD 269
Cdd:PRK10337 222 ALNQLFARTHAMMVRERRFTSDAAHELRSPLAALKVQTEVAQ-LSDDDPQARKKALLQLHAgidratrLVDQLLTLSRLD 300
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 270 RpqnelmltepdlpawlLAHLQDVQSVTPERAvnLLTSVIGDYGA-----LDMR---------------LMSRVLDNLLN 329
Cdd:PRK10337 301 S----------------LDNLQDVAEIPLEDL--LQSAVMDIYHTaqqagIDVRltlnahpvirtgqplLLSLLVRNLLD 362
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 330 NALRYSRTTVQVSLLLDGSqaTLIVEDDGPGIEADARERIFEPFVRldPSRDRATGGcGLGLAIVHSIALAMGGSVVCDE 409
Cdd:PRK10337 363 NAIRYSPQGSVVDVTLNAR--NFTVRDNGPGVTPEALARIGERFYR--PPGQEATGS-GLGLSIVRRIAKLHGMNVSFGN 437
|
250
....*....|..
gi 1185626239 410 SELGGAKFSFRW 421
Cdd:PRK10337 438 APEGGFEAKVSW 449
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
114-422 |
3.10e-21 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 95.61 E-value: 3.10e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 114 PRSHYVLAVGPVP--YLYFLHQMRLLDIALMALIAFSLAFPVFIWMRPHWQEMLRLESAAQRFGEGHLTERLHFDNGS-S 190
Cdd:PRK09835 161 GKPIYTLLIALSIdfHLHYINDLKNKLIMTASVISLLIVFIVLLAVHKGHAPIRSVSRQIQNITSKDLDVRLDPQTVPiE 240
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 191 FERLGVAFNQMADNINALIASKKQLIDGIAHELRTPLVRLRYRLE--MSENLTPPESQALN----RDIGQLEALIEELLT 264
Cdd:PRK09835 241 LEQLVLSFNHMIERIEDVFTRQSNFSADIAHEIRTPITNLITQTEiaLSQSRSQKELEDVLysnlEELTRMAKMVSDMLF 320
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 265 YARLDRPQNELMLTEPDLPAWLLAHLQDVQSVTPERAVNLLTSVIGDYGALDMRLMSRVLDNLLNNALRYSRT--TVQVS 342
Cdd:PRK09835 321 LAQADNNQLIPEKKMLDLADEVGKVFDFFEAWAEERGVELRFVGDPCQVAGDPLMLRRAISNLLSNALRYTPAgeAITVR 400
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 343 LLLDGSQATLIVEDDGPGIEADARERIFEPFVRLDPSRDRATGGCGLGLAIVHSIALAMGGSVVCdESELGGAKFSFRWP 422
Cdd:PRK09835 401 CQEVDHQVQLVVENPGTPIAPEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVVAHKGTVAV-TSDARGTRFVISLP 479
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
316-422 |
8.73e-20 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 84.08 E-value: 8.73e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 316 DMRLMSRVLDNLLNNALRYSRTTVQVSLLL---DGSQATLIVEDDGPGIEADARERIFEPFVRLDPSRDRATGGCGLGLA 392
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDGGRIRCILekfRLNRFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGLS 80
|
90 100 110
....*....|....*....|....*....|
gi 1185626239 393 IVHSIALAMGGSVVCDESELGGAKFSFRWP 422
Cdd:cd16925 81 IVKEFVELHGGTVTVSDAPGGGALFQVELP 110
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
219-423 |
1.44e-19 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 91.63 E-value: 1.44e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 219 IAHELRTPLVRLRYRLEMSENLTPPESQALNRDIGQ-----LEALIEELLTYARLDRPQNELMLTEPDLPAWLLAHLQDV 293
Cdd:PRK15347 405 ISHEIRTPLNGVLGALELLQNTPLTAEQMDLADTARqctlsLLAIINNLLDFSRIESGQMTLSLEETALLPLLDQAMLTI 484
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 294 QSVTPERAVNLLTSVIGD---YGALD-MRLmSRVLDNLLNNALRYSRTTvQVSLLLDGSQATLI--VEDDGPGIEADARE 367
Cdd:PRK15347 485 QGPAQSKSLTLRTFVGAHvplYLHLDsLRL-RQILVNLLGNAVKFTETG-GIRLRVKRHEQQLCftVEDTGCGIDIQQQQ 562
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 1185626239 368 RIFEPFVRLDPSRdratGGCGLGLAIVHSIALAMGGSVVCDeSELG-GAKFSFRWPV 423
Cdd:PRK15347 563 QIFTPFYQADTHS----QGTGLGLTIASSLAKMMGGELTLF-STPGvGSCFSLVLPL 614
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
319-421 |
5.88e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 82.07 E-value: 5.88e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 319 LMSRVLDNLLNNALRYSRTTVQVSLLLDG-SQATLIVEDDGPGIEADARERIFEPFVRLDPsrdRATGGCGLGLAIVHSI 397
Cdd:cd16940 13 LLFLLLRNLVDNAVRYSPQGSRVEIKLSAdDGAVIRVEDNGPGIDEEELEALFERFYRSDG---QNYGGSGLGLSIVKRI 89
|
90 100
....*....|....*....|....
gi 1185626239 398 ALAMGGSVVCDESELGGAKFSFRW 421
Cdd:cd16940 90 VELHGGQIFLGNAQGGGLEAWVRL 113
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
133-423 |
1.96e-18 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 87.21 E-value: 1.96e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 133 QMRLLDIALMALIAFSLAFPVFIW--MRPhwqeMLRLESAAQRFGEGHlTERLHFDNGSSFERLGVAFNQMADNINAlia 210
Cdd:PRK11100 181 ERRILWAGALLLGIALLIGAGVVWwlNRS----IRRLTRYADAVTEGK-PVPLPKLGSSELRELAQALESMRVKLEG--- 252
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 211 skKQLIDG----IAHELRTPLVRLRYRLE-MSENLTPPESQALNRDI----GQLEALIEELLTYARLDRPQnELMLTEPD 281
Cdd:PRK11100 253 --KAYVEQyvqtLTHELKSPLAAIRGAAElLQEDPPPEDRARFTGNIltqsARLQQLIDRLLELARLEQRQ-ELEVLEPV 329
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 282 LPAWLLAHLqdVQSVTPE---RAVNLLTSVIGDYGALDMRLMSRVLDNLLNNALRYS--RTTVQVSLLLDGSQATLIVED 356
Cdd:PRK11100 330 ALAALLEEL--VEAREAQaaaKGITLRLRPDDARVLGDPFLLRQALGNLLDNAIDFSpeGGTITLSAEVDGEQVALSVED 407
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1185626239 357 DGPGIEADARERIFEPFVRLdPSRDRATGGCGLGLAIVHSIALAMGGSVVCDESELGGAKFSFRWPV 423
Cdd:PRK11100 408 QGPGIPDYALPRIFERFYSL-PRPANGRKSTGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLPR 473
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
211-428 |
2.46e-18 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 87.65 E-value: 2.46e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 211 SKKQLIDGIAHELRTPLVRLRYRLEM-SENLTPPES----QALNRDIGQLEALIEELLTYARLDRPQNELMLT-EPDLPA 284
Cdd:PRK11466 443 AKSAFLAAMSHEIRTPLYGILGTAQLlADNPALNAQrddlRAITDSGESLLTILNDILDYSAIEAGGKNVSVSdEPFEPR 522
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 285 WLL-AHLQDVQSVTPERAVNLLTSVIGDYGAL---DMRLMSRVLDNLLNNALRYS-RTTVQVSLLLDGSQATLIVEDDGP 359
Cdd:PRK11466 523 PLLeSTLQLMSGRVKGRPIRLATDIADDLPTAlmgDPRRIRQVITNLLSNALRFTdEGSIVLRSRTDGEQWLVEVEDSGC 602
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1185626239 360 GIEADARERIFEPFVRLDPSRdratGGCGLGLAIVHSIALAMGGSVVCDESELGGAKFSFRWPVWHAMP 428
Cdd:PRK11466 603 GIDPAKLAEIFQPFVQVSGKR----GGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLPLRVATA 667
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
210-423 |
5.07e-18 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 86.18 E-value: 5.07e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 210 ASKKQLIDGIAHELRTPLVRLRYRLEM--SENLTPPESQALN---RDIGQLEALIEELLTYARLDRPQ------NELMlt 278
Cdd:PRK11360 388 AALGELVAGVAHEIRNPLTAIRGYVQIwrQQTSDPPSQEYLSvvlREVDRLNKVIDQLLEFSRPRESQwqpvslNALV-- 465
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 279 EPDLPAWLLAHLQDVQSVTPERAVNLLTSVIgdygalDMRLMSRVLDNLLNNAL----RYSRTTVQVSLLLDGSQAtLIV 354
Cdd:PRK11360 466 EEVLQLFQTAGVQARVDFETELDNELPPIWA------DPELLKQVLLNILINAVqaisARGKIRIRTWQYSDGQVA-VSI 538
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 355 EDDGPGIEADARERIFEPFVRLDPSrdratgGCGLGLAIVHSIALAMGGSVVCdESELG-GAKFSFRWPV 423
Cdd:PRK11360 539 EDNGCGIDPELLKKIFDPFFTTKAK------GTGLGLALSQRIINAHGGDIEV-ESEPGvGTTFTLYLPI 601
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
320-404 |
5.36e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 76.27 E-value: 5.36e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 320 MSRVLDNLLNNALRYS--RTTVQVSLLLDGSQATLIVEDDGPGIEADARERIFEPFVRLDPSRDraTGGCGLGLAIVHSI 397
Cdd:cd16923 1 LQRVFSNLLSNAIKYSpeNTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSRN--TEGAGLGLSIAKAI 78
|
....*..
gi 1185626239 398 ALAMGGS 404
Cdd:cd16923 79 IELHGGS 85
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
326-422 |
5.84e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 70.69 E-value: 5.84e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 326 NLLNNALRYSR--TTVQVSLLLDGSQATLIVEDDGPGIEADARERIFEPFVRLDPSRDRATGGCGLGLAIVHSiALAMGG 403
Cdd:cd16952 7 NLVSNAVKYTPpsDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVKH-VMSRHD 85
|
90 100
....*....|....*....|
gi 1185626239 404 SVVCDESELG-GAKFSFRWP 422
Cdd:cd16952 86 ARLLIASELGkGSRFTCLFP 105
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
320-422 |
1.16e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 69.66 E-value: 1.16e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 320 MSRVLDNLLNNALRYSRTT----VQVSLLLDGSQATLIVEDDGPGIEADARERIFEPFVRLDPsrDRATGGCGLGLAIVH 395
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRrpprIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLHS--REEYEGTGVGLAIVR 78
|
90 100
....*....|....*....|....*..
gi 1185626239 396 SIALAMGGSVVCDESELGGAKFSFRWP 422
Cdd:cd16921 79 KIIERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
315-420 |
1.87e-14 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 74.50 E-value: 1.87e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 315 LDMRLMSRVLDNLLNNALRYSRT------TVQVSLLLDGSQATLIVEDDGPGIEADARERIFEPFVRLDPSRDRatggcG 388
Cdd:COG3290 277 LSDTDLVTILGNLLDNAIEAVEKlpeeerRVELSIRDDGDELVIEVEDSGPGIPEELLEKIFERGFSTKLGEGR-----G 351
|
90 100 110
....*....|....*....|....*....|..
gi 1185626239 389 LGLAIVHSIALAMGGSVVCDESELGGAKFSFR 420
Cdd:COG3290 352 LGLALVKQIVEKYGGTIEVESEEGEGTVFTVR 383
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
181-423 |
3.07e-14 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 75.07 E-value: 3.07e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 181 ERLHFDNGSSFERLGVAFNQMAdniNALIASkkqlidgIAHELRTPLVRLRYRLEM------SENlTP--PESQALNRDI 252
Cdd:PRK10490 643 ERLTLTASEEQARLASEREQLR---NALLAA-------LSHDLRTPLTVLFGQAEIltldlaSEG-SPhaRQASEIRQQV 711
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 253 GQLEALIEELLTYARLDRPQNELMLtepdlpAWLLahLQDV-----QSVTPERAVNLLTSVIGDYGAL---DMRLMSRVL 324
Cdd:PRK10490 712 LNTTRLVNNLLDMARIQSGGFNLRK------EWLT--LEEVvgsalQMLEPGLSGHPINLSLPEPLTLihvDGPLFERVL 783
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 325 DNLLNNALRY--SRTTVQVSLLLDGSQATLIVEDDGPGIEADARERIFEPFVRLDpsRDRATGGCGLGLAIVHSIALAMG 402
Cdd:PRK10490 784 INLLENAVKYagAQAEIGIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDKFARGN--KESAIPGVGLGLAICRAIVEVHG 861
|
250 260
....*....|....*....|.
gi 1185626239 403 GSVVCDESELGGAKFSFRWPV 423
Cdd:PRK10490 862 GTIWAENRPEGGACFRVTLPL 882
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
312-405 |
4.02e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 68.69 E-value: 4.02e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 312 YGALDMRLMSRVLDNLLNNALRYSRT--TVQVSLLLDGSQATLIVEDDGPGIEADARERIFEPFVRLDPSRDRATGGCGL 389
Cdd:cd16947 13 YANANTEALQRILKNLISNAIKYGSDgkFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNSAKQGNGL 92
|
90
....*....|....*.
gi 1185626239 390 GLAIVHSIALAMGGSV 405
Cdd:cd16947 93 GLTITKRLAESMGGSI 108
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
323-416 |
4.07e-14 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 73.90 E-value: 4.07e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 323 VLDNLLNNALRYSRTTVQVSLLLDGSQATLIVEDDGPGIEADARERIFEPFVRLDPSRDratgGCGLGLAIVHSIALAMG 402
Cdd:PRK10815 382 VMGNVLDNACKYCLEFVEISARQTDEHLHIVVEDDGPGIPESKRELIFDRGQRADTLRP----GQGLGLSVAREITEQYE 457
|
90
....*....|....
gi 1185626239 403 GSVVCDESELGGAK 416
Cdd:PRK10815 458 GKISAGDSPLGGAR 471
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
323-422 |
6.50e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 67.31 E-value: 6.50e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 323 VLDNLLNNAL------RYSRTTVQVSLLLDGSQATLIVEDDGPGIEADARERIFEPFVRLDPSRDRatggcGLGLAIVHS 396
Cdd:cd16915 4 IVGNLIDNALdalaatGAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVSTKGQGER-----GIGLALVRQ 78
|
90 100
....*....|....*....|....*.
gi 1185626239 397 IALAMGGSVVCDESELGGAKFSFRWP 422
Cdd:cd16915 79 SVERLGGSITVESEPGGGTTFSIRIP 104
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
323-419 |
9.86e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 66.71 E-value: 9.86e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 323 VLDNLLNNAL----RYSRTTVQVSLLLDGSQATLIVEDDGPGIEADARERIFEPFVRLDPsrdrATGGCGLGLAIVHSIA 398
Cdd:cd16976 4 VLMNLLQNALdamgKVENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTKP----VGKGTGLGLSISYGIV 79
|
90 100
....*....|....*....|.
gi 1185626239 399 LAMGGSVVCDESELGGAKFSF 419
Cdd:cd16976 80 EEHGGRLSVANEEGAGARFTF 100
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
316-420 |
2.59e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 65.95 E-value: 2.59e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 316 DMRLMSRVLDNLLNNALRYSRT--TVQVSLLLDGSQATLIVEDDGPGIEADARERIFEPFVRLDPSRDrATGGCGLGLAI 393
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEggTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRR-SGGHYGMGLYI 79
|
90 100
....*....|....*....|....*..
gi 1185626239 394 VHSIALAMGGSVVCDESELGGAKFSFR 420
Cdd:cd16975 80 AKNLVEKHGGSLIIENSQKGGAEVTVK 106
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
320-422 |
2.02e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 63.19 E-value: 2.02e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 320 MSRVLDNLLNNA------------LRySRTTVQVSLLLDGSQ--ATLIVEDDGPGIEADARERIFEPFVrldPSRDratG 385
Cdd:cd16918 1 LIQVFLNLVRNAaqalagsggeiiLR-TRTQRQVTLGHPRHRlaLRVSVIDNGPGIPPDLQDTIFYPMV---SGRE---N 73
|
90 100 110
....*....|....*....|....*....|....*..
gi 1185626239 386 GCGLGLAIVHSIALAMGGSVVCDeSELGGAKFSFRWP 422
Cdd:cd16918 74 GTGLGLAIAQNIVSQHGGVIECD-SQPGHTVFSVSLP 109
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
320-422 |
2.44e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 63.36 E-value: 2.44e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 320 MSRVLDNLLNNALRYS---RTTVQVSLLLDGSQATLIVEDDGPGIEADARERIFEPFVRLDPSRDRATGGCGLGLAIVHS 396
Cdd:cd16953 1 LGQVLRNLIGNAISFSppdTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERPANEAFGQHSGLGLSISRQ 80
|
90 100 110
....*....|....*....|....*....|
gi 1185626239 397 IALAMGGSVVC----DESELGGAKFSFRWP 422
Cdd:cd16953 81 IIEAHGGISVAenhnQPGQVIGARFTVQLP 110
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
323-422 |
3.96e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 62.41 E-value: 3.96e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 323 VLDNLLNNAL-------RYSRT-TVQVSLLLDGSqATLIVEDDGPGIEADARERIFEPFVRLDPSrdratgGCGLGLAIV 394
Cdd:cd16920 4 VLINLVRNGIeamseggCERRElTIRTSPADDRA-VTISVKDTGPGIAEEVAGQLFDPFYTTKSE------GLGMGLSIC 76
|
90 100
....*....|....*....|....*...
gi 1185626239 395 HSIALAMGGSVVCDESELGGAKFSFRWP 422
Cdd:cd16920 77 RSIIEAHGGRLSVESPAGGGATFQFTLP 104
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
319-423 |
6.69e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 61.67 E-value: 6.69e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 319 LMSRVLDNLLNNAL----RYSRTTVQVSLLLDgsQATLIVEDDGPGIEADARERIFEPFVRLDPSRDratgGCGLGLAIV 394
Cdd:cd16943 3 QLNQVLLNLLVNAAqameGRGRITIRTWAHVD--QVLIEVEDTGSGIDPEILGRIFDPFFTTKPVGE----GTGLGLSLS 76
|
90 100 110
....*....|....*....|....*....|
gi 1185626239 395 HSIALAMGGSVVCdESELG-GAKFSFRWPV 423
Cdd:cd16943 77 YRIIQKHGGTIRV-ASVPGgGTRFTIILPI 105
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
317-426 |
3.01e-11 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 65.38 E-value: 3.01e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 317 MRLmSRVLDNLLNNALRYSRT---TVQVSLllDGSQATLIVEDDGPGIEADARERIFEPFVRLDPSRDRATGGCGLGLAI 393
Cdd:PRK10841 561 MRL-QQVISNLLSNAIKFTDTgciVLHVRV--DGDYLSFRVRDTGVGIPAKEVVRLFDPFFQVGTGVQRNFQGTGLGLAI 637
|
90 100 110
....*....|....*....|....*....|....
gi 1185626239 394 VHSIALAMGGSVVCdESELG-GAKFSFRWPVWHA 426
Cdd:PRK10841 638 CEKLINMMDGDISV-DSEPGmGSQFTIRIPLYGA 670
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
214-423 |
6.20e-11 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 64.23 E-value: 6.20e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 214 QLIDGIAHELRTPLVRLRYRLE-MSENLTPPESQALN---RDIGQLEALIEELLTyarLDRPQN---------------- 273
Cdd:COG5809 272 ELAAGIAHEIRNPLTSLKGFIQlLKDTIDEEQKTYLDimlSELDRIESIISEFLV---LAKPQAikyepkdlntlieevi 348
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 274 ELMLTEpdlpawllAHLQDVQ-SVTPERAVNLltsVIGDYGALdmrlmSRVLDNLLNNALRY--SRTTVQVSL-LLDGSQ 349
Cdd:COG5809 349 PLLQPQ--------ALLKNVQiELELEDDIPD---ILGDENQL-----KQVFINLLKNAIEAmpEGGNITIETkAEDDDK 412
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1185626239 350 ATLIVEDDGPGIEADARERIFEPFvrldpsrdrAT---GGCGLGLAIVHSIALAMGGSVVCdESELG-GAKFSFRWPV 423
Cdd:COG5809 413 VVISVTDEGCGIPEERLKKLGEPF---------YTtkeKGTGLGLMVSYKIIEEHGGKITV-ESEVGkGTTFSITLPI 480
|
|
| marine_sort_HK |
TIGR03785 |
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is ... |
219-405 |
7.47e-11 |
|
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is paired with an adjacent response regulator (TIGR03787) gene. It co-occurs with a variant sortase enzyme (TIGR03784), usually in the same gene neighborhood, in proteobacterial species most of which are marine, and with an LPXTG motif-containing sortase target conserved protein (TIGR03788). Sortases and LPXTG proteins are far more common in Gram-positive bacteria, where sortase systems mediate attachment to the cell wall or cross-linking of pilin structures. We give this predicted sensor histidine kinase the gene symbol psdS, for Proteobacterial Dedicated Sortase system Sensor histidine kinase.
Pssm-ID: 163497 [Multi-domain] Cd Length: 703 Bit Score: 63.99 E-value: 7.47e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 219 IAHELRTPLVRLRYRLEMSENL-TPPESQA-LNR---DIGQLEALIEELLTYARLdrpqnELMLTEPDLPAWLLAHL--- 290
Cdd:TIGR03785 492 LSHELRTPVAVVRSSLENLELQaLEQEKQKyLERareGTERLSMILNNMSEATRL-----EQAIQSAEVEDFDLSEVlsg 566
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 291 --QDVQSVTPERAVNLltsvIGDYGALDMR----LMSRVLDNLLNNALRYSR--TTVQVSLLLDGSQATLIVEDDGPGIE 362
Cdd:TIGR03785 567 cmQGYQMTYPPQRFEL----NIPETPLVMRgspeLIAQMLDKLVDNAREFSPedGLIEVGLSQNKSHALLTVSNEGPPLP 642
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 1185626239 363 ADARERIFEPFVRLDPSRDRATGGCGLGLAIVHSIALAMGGSV 405
Cdd:TIGR03785 643 EDMGEQLFDSMVSVRDQGAQDQPHLGLGLYIVRLIADFHQGRI 685
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
214-398 |
9.02e-11 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 63.60 E-value: 9.02e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 214 QLIDGIAHELRTPLVRLR----------------YRLEMSEnltppesqalnrdIGQLEALIEELLTYARLDRPQNE--- 274
Cdd:COG5805 289 QLAAGIAHEIRNPLTSIKgflqllqpgiedkeeyFDIMLSE-------------LDRIESIISEFLALAKPQAVNKEken 355
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 275 --------LMLTEPDlpawllAHLQDVQSVTperavNLLTSVIGDYGalDMRLMSRVLDNLLNNALRY--SRTTVQVSLL 344
Cdd:COG5805 356 ineliqdvVTLLETE------AILHNIQIRL-----ELLDEDPFIYC--DENQIKQVFINLIKNAIEAmpNGGTITIHTE 422
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 1185626239 345 LDGSQATLIVEDDGPGIEADARERIFEPFVRLDPSrdratgGCGLGLAIVHSIA 398
Cdd:COG5805 423 EEDNSVIIRVIDEGIGIPEERLKKLGEPFFTTKEK------GTGLGLMVSYKII 470
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
319-405 |
1.00e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 58.63 E-value: 1.00e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 319 LMSRVLDNLLNNALRYSRT--TVQVSLLLDGSQATLIVEDDGPGIEADARERIFEPFVRLdPSRDRATGGCGLGLAIVHS 396
Cdd:cd16945 4 LLRQAINNLLDNAIDFSPEggLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSL-PRPHSGQKSTGLGLAFVQE 82
|
....*....
gi 1185626239 397 IALAMGGSV 405
Cdd:cd16945 83 VAQLHGGRI 91
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
218-428 |
3.79e-10 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 62.00 E-value: 3.79e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 218 GIAHELRTPLVRLRYRLEMSENLTPPESQAlNRDIGQLEA-------LIEELLTYAR-LDRPQ-----NELmLTE--PDL 282
Cdd:PRK13837 456 GIAHNFNNILGAILGYAEMALNKLARHSRA-ARYIDEIISagararlIIDQILAFGRkGERNTkpfdlSEL-VTEiaPLL 533
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 283 PAWLLAHLQDVQSVTPERAVnlltsVIGDYGALDMRLMsrvldNLLNNALRYSRTTVQVSLLLD---------------- 346
Cdd:PRK13837 534 RVSLPPGVELDFDQDQEPAV-----VEGNPAELQQVLM-----NLCSNAAQAMDGAGRVDISLSraklrapkvlshgvlp 603
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 347 -GSQATLIVEDDGPGIEADARERIFEPFVRLDPsrdratGGCGLGLAIVHSIALAMGGSVVCDeSELG-GAKFSFRWPVW 424
Cdd:PRK13837 604 pGRYVLLRVSDTGAGIDEAVLPHIFEPFFTTRA------GGTGLGLATVHGIVSAHAGYIDVQ-STVGrGTRFDVYLPPS 676
|
....
gi 1185626239 425 HAMP 428
Cdd:PRK13837 677 SKVP 680
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
217-423 |
3.84e-10 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 60.02 E-value: 3.84e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 217 DGIAHELrtplVRLRYRLEMSENLTPPESQALNRDIGQLEALIEELLTYAR----LDRPQNelmLTEPDLPA---WLLAH 289
Cdd:COG4585 63 DGVGQSL----SAIKLQLEAARRLLDADPEAAREELEEIRELAREALAELRrlvrGLRPPA---LDDLGLAAaleELAER 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 290 LQDVQSVTPEravnllTSVIGDYGALDMRLMS---RVLDNLLNNALRYSR-TTVQVSLLLDGSQATLIVEDDGPGIEADa 365
Cdd:COG4585 136 LLRAAGIRVE------LDVDGDPDRLPPEVELalyRIVQEALTNALKHAGaTRVTVTLEVDDGELTLTVRDDGVGFDPE- 208
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 1185626239 366 rerifepfvrldpsrdrATGGCGLGLAIVHSIALAMGGSVVCDESELGGAKFSFRWPV 423
Cdd:COG4585 209 -----------------AAPGGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATLPL 249
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
215-423 |
7.49e-10 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 60.57 E-value: 7.49e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 215 LIDGIAHELRTPLVRLRYRLEMSENLTPPESQA------LNRDIGQLEALIEELLtyaRLDRPqNELMLTEPDLPAwLLA 288
Cdd:PRK10364 240 LAAGVAHEIRNPLSSIKGLAKYFAERAPAGGEAhqlaqvMAKEADRLNRVVSELL---ELVKP-THLALQAVDLND-LIN 314
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 289 H-LQDVQSVTPERAVNLLTSVIGDYGAL--DMRLMSRVLDNLLNNALRY--SRTTVQVSLLLDGSQATLIVEDDGPGIEA 363
Cdd:PRK10364 315 HsLQLVSQDANSREIQLRFTANDTLPEIqaDPDRLTQVLLNLYLNAIQAigQHGVISVTASESGAGVKISVTDSGKGIAA 394
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 364 DARERIFEPFVRLDPSrdratgGCGLGLAIVHSIALAMGGSVVCDESELGGAKFSFRWPV 423
Cdd:PRK10364 395 DQLEAIFTPYFTTKAE------GTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPV 448
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
316-415 |
1.23e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 55.62 E-value: 1.23e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 316 DMRLMSRVLDNLLNNA--------LRYSRTTVQVSLLLDGSQAtLIVEDDGPGIEADARERIFEPFVRLDPSrdratgGC 387
Cdd:cd16944 1 DTTQISQVLTNILKNAaeaiegrpSDVGEVRIRVEADQDGRIV-LIVCDNGKGFPREMRHRATEPYVTTRPK------GT 73
|
90 100
....*....|....*....|....*...
gi 1185626239 388 GLGLAIVHSIALAMGGSVVCDESELGGA 415
Cdd:cd16944 74 GLGLAIVKKIMEEHGGRISLSNREAGGA 101
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
160-423 |
1.38e-09 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 60.52 E-value: 1.38e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 160 HWQEMLRL---ESAAQRFGEGHLTERLHFDNGSSFERlgvafnqmADNINALIAsKKQLIDGIAHELRTPLVRLRYRLEM 236
Cdd:PRK09959 666 HWHTLCNLpasDHAVYICGWQDITETRDLIHALEVER--------NKAINATVA-KSQFLATMSHEIRTPISSIMGFLEL 736
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 237 --SENLTPP---ESQALNRDIGQ-LEALIEELLTYARLDRPQNELMLTEPDLPAWLLAHLQDVQSVTPERAVNL-LTSVI 309
Cdd:PRK09959 737 lsGSGLSKEqrvEAISLAYATGQsLLGLIGEILDVDKIESGNYQLQPQWVDIPTLVQNTCHSFGAIAASKSIALsCSSTF 816
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 310 GDYG--ALDMRLMSRVLDNLLNNALRYSR---TTVQVSLL-LDGSQAT--LIVEDDGPGIEADARERIFEPFVRLDPSRD 381
Cdd:PRK09959 817 PDHYlvKIDPQAFKQVLSNLLSNALKFTTegaVKITTSLGhIDDNHAVikMTIMDSGSGLSQEEQQQLFKRYSQTSAGRQ 896
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 1185626239 382 RAtgGCGLGLAIVHSIALAMGGSVVCDESELGGAKFSFRWPV 423
Cdd:PRK09959 897 QT--GSGLGLMICKELIKNMQGDLSLESHPGIGTTFTITIPV 936
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
211-269 |
2.20e-08 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 50.67 E-value: 2.20e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1185626239 211 SKKQLIDGIAHELRTPLVRLRYRLEMSENLTPPESQA-----LNRDIGQLEALIEELLTYARLD 269
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELLRDEKLDEEQReyletILRSAERLLRLINDLLDLSRIE 64
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
69-423 |
3.26e-08 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 55.41 E-value: 3.26e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 69 MDLNLSFDLRVEPLNHYKLDAATTQRLREGDIVALDDQYTFIQRIPRSHYVLaVGPVPYLYFLHQMRLLDIALMALIAFS 148
Cdd:COG2972 88 LLLLLLILLLSLLLLLALILLLALLLLLSILLLILGLLLIILLLLSLLGWTL-VSLIPKSELFRGLFSLRRLILLIILLL 166
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 149 LAFPVFIWMRPHW---QEMLRLESAAQRFGEGHLTeRLHFDNGSSFERLGVAFNQMADNINALIASKKQLidgiahELRt 225
Cdd:COG2972 167 LLLALLLSYLLSRsitRPIKRLKKAMKKVEKGDLV-RLEVSGNDEIGILARSFNEMVERIKELIEEVYEL------ELE- 238
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 226 pLVRLRYR-LEMSENltpP----------ESQALNRDIGQLEALIEELLTYAR--LDRPQNELMLTEPdlpawlLAHLQD 292
Cdd:COG2972 239 -KKEAELKaLQAQIN---PhflfntlnsiRWLAELEDPEEAEEMLEALSKLLRysLSKGDELVTLEEE------LELIKS 308
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 293 ---VQSVtpeRAVNLLTSVI-GDYGALDMRLMSRVLDNLLNNALRYS------RTTVQVSLLLDGSQATLIVEDDGPGIE 362
Cdd:COG2972 309 yleIQKL---RFGDRLEVEIeIDEELLDLLIPKLILQPLVENAIEHGiepkegGGTIRISIRKEGDRLVITVEDNGVGMP 385
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1185626239 363 ADARERIFEPFVRLDPSRdratggcGLGLAIVHS-IALAMGGSVVCD-ESELG-GAKFSFRWPV 423
Cdd:COG2972 386 EEKLEKLLEELSSKGEGR-------GIGLRNVRErLKLYYGEEYGLEiESEPGeGTTVTIRIPL 442
|
|
| KinB |
COG5806 |
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ... |
219-418 |
4.08e-08 |
|
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 54.87 E-value: 4.08e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 219 IAHELRTPLVRLRYRLE-MSENLTPPESQ------ALNrDIGQLEALIEELLTYARldrPQNE--------------LML 277
Cdd:COG5806 208 IAHEVRNPLTVVRGFIQlLQEPELSDEKRkqyiriALE-ELDRAEAIITDYLTFAK---PQPEklekidvseelehvIDV 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 278 TEPdlpawlLAHLQDVQ-SVTPERAVNlltsVIGDYGALdmrlmSRVLDNLLNNALRYSRT--TVQVSLLLDGSQATLIV 354
Cdd:COG5806 284 LSP------YANMNNVEiQTELEPGLY----IEGDRQKL-----QQCLINIIKNGIEAMPNggTLTIDVSIDKNKVIISI 348
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1185626239 355 EDDGPGIEADARERIFEPFVRLDpsrdraTGGCGLGLAIVHSIALAMGGSVVCdESELG-GAKFS 418
Cdd:COG5806 349 KDTGVGMTKEQLERLGEPYFSTK------EKGTGLGTMVSYRIIEAMNGTIRV-ESEVGkGTTFT 406
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
211-269 |
6.53e-08 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 49.10 E-value: 6.53e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1185626239 211 SKKQLIDGIAHELRTPLVRLRYRLEM--SENLTPPESQALN---RDIGQLEALIEELLTYARLD 269
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELllDTELSEEQREYLEtilREAERLLRLINDLLDLSRIE 64
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
322-422 |
2.93e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 47.93 E-value: 2.93e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 322 RVLDNLLNNALRYSR-TTVQVSLLLDGSQATLIVEDDGPGIEADARErifepfvrldpsrdratGGCGLGLAIVHSIALA 400
Cdd:cd16917 3 RIVQEALTNALKHAGaSRVRVTLSYTADELTLTVVDDGVGFDGPAPP-----------------GGGGFGLLGMRERAEL 65
|
90 100
....*....|....*....|..
gi 1185626239 401 MGGSVVCDESELGGAKFSFRWP 422
Cdd:cd16917 66 LGGTLTIGSRPGGGTRVTARLP 87
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
209-267 |
4.01e-07 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 46.82 E-value: 4.01e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1185626239 209 IASKKQLIDGIAHELRTPLVRLRYRLEM-SENLTPPESQA-----LNRDIGQLEALIEELLTYAR 267
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELlEEELLDDEEQReylerIREEAERLLRLINDLLDLSR 65
|
|
| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
164-210 |
4.22e-07 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 46.47 E-value: 4.22e-07
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 1185626239 164 MLRLESAAQRFGEGHLTERLHFDNGSSFERLGVAFNQMADNINALIA 210
Cdd:smart00304 7 LRRLAEAAQRIADGDLTVRLPVDGRDEIGELARAFNEMADRLEETIA 53
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
307-419 |
5.96e-07 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 51.77 E-value: 5.96e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 307 SVIGDygalDMRLmSRVLDNLLNNALRYS-RTTVQVSL---LLDGSQATLIVE--DDGPGIEADARERIFEPFVRLDPSR 380
Cdd:PRK11107 401 NVIGD----PLRL-QQIITNLVGNAIKFTeSGNIDILVelrALSNTKVQLEVQirDTGIGISERQQSQLFQAFRQADASI 475
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 1185626239 381 DRATGGCGLGLAIVHSIALAMGGSVVCdESELG-GAKFSF 419
Cdd:PRK11107 476 SRRHGGTGLGLVITQKLVNEMGGDISF-HSQPNrGSTFWF 514
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
344-413 |
8.40e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 47.37 E-value: 8.40e-07
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 344 LLDGSQATLIVEDDGPGIEADARERIFEPFVRLDPsrdrATGGCGLGLAIVHSIALAMGGSVVCDeSELG 413
Cdd:cd16919 42 LIPGNYVCLEVSDTGSGMPAEVLRRAFEPFFTTKE----VGKGTGLGLSMVYGFVKQSGGHLRIY-SEPG 106
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
212-418 |
1.27e-06 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 50.71 E-value: 1.27e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 212 KKQLIDGIAHELRTPL---VRLRyRLEMSENLTPPESQALN-------------RDIGQLEalieelltyaRLDRPQNEL 275
Cdd:PRK11091 283 KTTFISTISHELRTPLngiVGLS-RILLDTELTAEQRKYLKtihvsaitlgnifNDIIDMD----------KMERRKLQL 351
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 276 MLTEPDLPAW---------LLAHLQDVQSVTpERAVNLLTSVIGDygalDMRLmSRVLDNLLNNALRYSRT-TVQVSLLL 345
Cdd:PRK11091 352 DNQPIDFTDFladlenlsgLQAEQKGLRFDL-EPLLPLPHKVITD----GTRL-RQILWNLISNAVKFTQQgGVTVRVRY 425
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1185626239 346 D-GSQATLIVEDDGPGIEADARERIFEPFVRLDPSRD--RATGgCGLGLAIVHSIALAMGGSVVCDeSELG-GAKFS 418
Cdd:PRK11091 426 EeGDMLTFEVEDSGIGIPEDELDKIFAMYYQVKDSHGgkPATG-TGIGLAVSKRLAQAMGGDITVT-SEEGkGSCFT 500
|
|
| nifL_nitrog |
TIGR02938 |
nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation ... |
305-423 |
1.65e-06 |
|
nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation positive regulator protein NifA, and is therefore a negative regulator. It binds NifA. NifA and NifL are encoded by adjacent genes. [Central intermediary metabolism, Nitrogen fixation, Regulatory functions, Protein interactions]
Pssm-ID: 131984 [Multi-domain] Cd Length: 494 Bit Score: 50.29 E-value: 1.65e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 305 LTSVIGdyGALDMRLMSRVL-DNLLN--NALRYSRTTVQVSLLLDGSQATLIVEDDGPGIEADARERIFEPFVRLDPSRD 381
Cdd:TIGR02938 378 LPAILG--RELQLRSLFKALvDNAIEamNIKGWKRRELSITTALNGDLIVVSILDSGPGIPQDLRYKVFEPFFTTKGGSR 455
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 1185626239 382 RatgGCGLGLAIVHSIALAMGGSVVCDESELGGAKFSFRWPV 423
Cdd:TIGR02938 456 K---HIGMGLSVAQEIVADHGGIIDLDDDYSEGCRIIVEFRV 494
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
316-422 |
1.69e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 46.51 E-value: 1.69e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 316 DMRLMSRVLDNLLNNALRYSRTTVQVSLLL--DGSQATLIVEDDGPGIEADARERIFEPFVRLDPSRdRATGGCGLGLAI 393
Cdd:cd16948 2 DAKWLSFIIGQIVSNALKYSKQGGKIEIYSetNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGR-NFQESTGMGLYL 80
|
90 100
....*....|....*....|....*....
gi 1185626239 394 VHSIALAMGGSVVCDESELGGAKFSFRWP 422
Cdd:cd16948 81 VKKLCDKLGHKIDVESEVGEGTTFTITFP 109
|
|
| HAMP |
cd06225 |
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ... |
166-205 |
4.12e-06 |
|
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.
Pssm-ID: 381743 [Multi-domain] Cd Length: 45 Bit Score: 43.59 E-value: 4.12e-06
10 20 30 40
....*....|....*....|....*....|....*....|
gi 1185626239 166 RLESAAQRFGEGHLTERLHFDNGSSFERLGVAFNQMADNI 205
Cdd:cd06225 6 RLTEAARRIAEGDLDVRVPVRSKDEIGELARAFNQMAERL 45
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
327-398 |
5.13e-06 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 45.67 E-value: 5.13e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1185626239 327 LLNNALRYSR-----TTVQVSLLLDGSQATLIVEDDGPGieadareriFEPFVRLDPSRDRATGgcGLGLAIVHSIA 398
Cdd:COG2172 42 AVTNAVRHAYggdpdGPVEVELELDPDGLEIEVRDEGPG---------FDPEDLPDPYSTLAEG--GRGLFLIRRLM 107
|
|
| HATPase_RsbW-like |
cd16936 |
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ... |
323-398 |
5.93e-06 |
|
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.
Pssm-ID: 340413 [Multi-domain] Cd Length: 91 Bit Score: 44.57 E-value: 5.93e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 323 VLDNLLNNALRYSR-----TTVQVSLLLDGSQATLIVEDDGPGieadareriFEPFVRLDPSRDRATGGcgLGLAIVHSI 397
Cdd:cd16936 4 AVSEAVTNAVRHAYrhdgpGPVRLELDLDPDRLRVEVTDSGPG---------FDPLRPADPDAGLREGG--RGLALIRAL 72
|
.
gi 1185626239 398 A 398
Cdd:cd16936 73 M 73
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
158-397 |
6.62e-06 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 47.77 E-value: 6.62e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 158 RPHWqemlrLESAAQRFGEGH-LTERLHFDNGssfERLGVAFNQMADNINAliaskKQLIDGIAHELRTPLVRLRYRLEM 236
Cdd:PRK11073 88 RSHI-----LSLTAQRLPEGMiLLEMAPMDNQ---RRLSQEQLQHAQQVAA-----RDLVRGLAHEIKNPLGGLRGAAQL 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 237 SENLTPPES-----QALNRDIGQLEALIEELLTyarldrPQNELMLTEpdlpawllahlQDVQSVTpERAVNLLT----- 306
Cdd:PRK11073 155 LSKALPDPAlteytKVIIEQADRLRNLVDRLLG------PQRPGTHVT-----------ESIHKVA-ERVVQLVSlelpd 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 307 --SVIGDYG------ALDMRLMSRVLDNLLNNALRY-----------SRTTVQVSLllDGSQ----ATLIVEDDGPGIEA 363
Cdd:PRK11073 217 nvRLIRDYDpslpelAHDPDQIEQVLLNIVRNALQAlgpeggtitlrTRTAFQLTL--HGERyrlaARIDIEDNGPGIPP 294
|
250 260 270
....*....|....*....|....*....|....
gi 1185626239 364 DARERIFEPFVRldpSRDratGGCGLGLAIVHSI 397
Cdd:PRK11073 295 HLQDTLFYPMVS---GRE---GGTGLGLSIARNL 322
|
|
| HAMP |
pfam00672 |
HAMP domain; |
157-207 |
1.50e-05 |
|
HAMP domain;
Pssm-ID: 459898 [Multi-domain] Cd Length: 53 Bit Score: 42.23 E-value: 1.50e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 1185626239 157 MRPHWQEMLRLESAAQRFGEGHLTERLHFDNGSSFERLGVAFNQMADNINA 207
Cdd:pfam00672 3 ARRILRPLRRLAEAARRIASGDLDVRLPVSGRDEIGELARAFNQMAERLRE 53
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
207-404 |
4.07e-05 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 45.83 E-value: 4.07e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 207 ALIASKKQLIDGIAHELRTPLVRLRYRLEMSENLTPPESQALNRD-IGQLEALIE-------ELLTYAR-LDRPQNELML 277
Cdd:COG4192 428 AKMAVVGQTMTSLAHELNQPLNAMSMYLFSAKKALEQENYAQLPTsLDKIEGLIErmdkiikSLRQFSRkSDTPLQPVDL 507
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 278 TEPDLPAWLL----AHLQDVQSVTPERAVnlltsVIGDYGALDmrlmsRVLDNLLNNALRYSRTTVQVSLLLDGSQA--T 351
Cdd:COG4192 508 RQVIEQAWELvesrAKPQQITLHIPDDLM-----VQGDQVLLE-----QVLVNLLVNALDAVATQPQISVDLLSNAEnlR 577
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 1185626239 352 LIVEDDGPGIeaDARERIFEPFVrldpsrDRATGGCGLGLAIVHSIALAMGGS 404
Cdd:COG4192 578 VAISDNGNGW--PLVDKLFTPFT------TTKEVGLGLGLSICRSIMQQFGGD 622
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
338-413 |
1.02e-04 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 44.66 E-value: 1.02e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1185626239 338 TVQVSLLLDGSQATLIVEDDGPGIEADARERIFEPFVrldPSRDRATgGCGLGLAIVHSIALAMGGSVVCdESELG 413
Cdd:PRK13557 313 LAMYHGLPPGRYVSIAVTDTGSGMPPEILARVMDPFF---TTKEEGK-GTGLGLSMVYGFAKQSGGAVRI-YSEVG 383
|
|
| Tar |
COG0840 |
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms]; |
131-220 |
2.08e-04 |
|
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
Pssm-ID: 440602 [Multi-domain] Cd Length: 533 Bit Score: 43.47 E-value: 2.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 131 LHQMRLLDIALMALIAFSLAFPVFIwMRPHWQEMLRLESAAQRFGEGHLTERLHFDNGSSFERLGVAFNQMADNINALIA 210
Cdd:COG0840 178 ALALALLAAALLALVALAIILALLL-SRSITRPLRELLEVLERIAEGDLTVRIDVDSKDEIGQLADAFNRMIENLRELVG 256
|
90
....*....|
gi 1185626239 211 SKKQLIDGIA 220
Cdd:COG0840 257 QVRESAEQVA 266
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
327-423 |
2.60e-04 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 43.36 E-value: 2.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 327 LLNNALRY-----SRTTVQVSLLLDGSQATLIVEDDGPGIEADArerifepfvrlDPSRDRatggcGLGLAIVHSIALAM 401
Cdd:COG3920 407 LVTNALKHaflsgEGGRIRVSWRREDGRLRLTVSDNGVGLPEDV-----------DPPARK-----GLGLRLIRALVRQL 470
|
90 100
....*....|....*....|..
gi 1185626239 402 GGSVVCDESElgGAKFSFRWPV 423
Cdd:COG3920 471 GGTLELDRPE--GTRVRITFPL 490
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
323-422 |
4.20e-04 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 42.59 E-value: 4.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 323 VLDNLLNNAL----RYSRTTVQVSLLLDGSQATLIVEDDGPGIEADARERIFEpfvrldpsRDRATGGC--GLGLAIVHS 396
Cdd:PRK11086 437 ILGNLIENALeavgGEEGGEISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIFD--------KGYSTKGSnrGVGLYLVKQ 508
|
90 100
....*....|....*....|....*..
gi 1185626239 397 IALAMGGSVVCdESELG-GAKFSFRWP 422
Cdd:PRK11086 509 SVENLGGSIAV-ESEPGvGTQFFVQIP 534
|
|
| HAMP |
COG2770 |
HAMP domain [Signal transduction mechanisms]; |
17-416 |
1.01e-03 |
|
HAMP domain [Signal transduction mechanisms];
Pssm-ID: 442051 [Multi-domain] Cd Length: 631 Bit Score: 41.64 E-value: 1.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 17 LVMTLLVGLVYKFTAERAGRQSLDDLMKSSLYLMRSELREIPPREWGKTLKEMDLNLSFDLRVEPLNHYKLDAATTQRLR 96
Cdd:COG2770 92 LALLLLLLLALLLLLAALLLLLLLAALALLLLLLLLLAALLALLLALALLALLLGLAAARLLLAALLALAAALALALGAG 171
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 97 EGDIVALDDQYTFIQRIPRSHYVLAVGPVPYLYFLHQMRLLDIALMALIAFSLAFPVFIWM-----RPhwqeMLRLESAA 171
Cdd:COG2770 172 ELLLLADLAAAIAALLAALLLLLLGGLLLVVLLEAALAALLLLLLLALLALLLALLLALLLarritRP----LRRLAEAA 247
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 172 QRFGEGHLTERLHFDNGSSFERLGVAFNQMADNINALIASKKQLIDGIAHELR----------TPLVRLRYRLEMSENLT 241
Cdd:COG2770 248 RRIAAGDLDVRIPVSRKDEIGELARAFNRMADSLRESIEEAEEEEELAEAELArlleallellLALLLLLLALLLLAAAA 327
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 242 PPESQALNRDIGQLEALIEELLTYARLDRPQNELMLTEPDLPAWLLAHLQDVQSVTPERAVNLLTSVIGDYGALDMRLMS 321
Cdd:COG2770 328 LLLELLLLLLLALLLLLLLAADLLLALALAALLLLLALELLLEAELLVLLALEALALEAELAAVLALLAALAAALLLLEL 407
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 322 RVLDNLLNNALRYSRTTVQVSLLLDGSQATLIVEDDGPGIEADARERIFEPFVRLDPSRDRATGGCGLGLAIVHSIALAM 401
Cdd:COG2770 408 ALEELVLALLALALLALAAAAAAAEAAAAALELAAAAIAAAAAAEAEGGLAELEAEELVAAAEALLLLAALLLLAALGAL 487
|
410
....*....|....*
gi 1185626239 402 GGSVVCDESELGGAK 416
Cdd:COG2770 488 ELLLLEEEEEAGAAA 502
|
|
| NarQ |
COG3850 |
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ... |
76-371 |
1.34e-03 |
|
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];
Pssm-ID: 443059 [Multi-domain] Cd Length: 448 Bit Score: 41.02 E-value: 1.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 76 DLRVEPLNHYKLDAATTQRLREGDIVALDDQYTFIQRIPRSHYVLAVGPVPYLYFLHQMRLLDIALMALIAFSLAFPVFI 155
Cdd:COG3850 58 LLAALLLLLSLGLLALLLALLLLLLLLLLAALLSLLLLLLLLLLLLLLLLLLLLAAAINRKLALLRLLLALLLALLLAYL 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 156 WMRPHWQEMLRLESAAQRFGEGHLTERLHFDNGSSFERLGVAFNQMADNINALIASKKQLIDGIAHELRTPLVRLRYRLE 235
Cdd:COG3850 138 LRRRIVRPLRRLTQAAERIARGDFDARVPVSGRDELGTLARAFNRMADELQELYAELEEEEELEAELELLALLDELLLLA 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 236 MSENLTPPESQALNRDIGQLEALIEELLTYARLDRPQNELMLTEPDLPAWLLAHLQDVQSVTPERAVNLLTSVIGDYGAL 315
Cdd:COG3850 218 ALLLLLALLLALLLAALLAALLLLLLLQDALAESELLALNILAGLLELLLALLLLLLASALLLLELELLALLLELVELLA 297
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 1185626239 316 DMRLMSRVLDNLLNNALRYSRTTVQVSLLLDGSQATLIVEDDGPGIEADARERIFE 371
Cdd:COG3850 298 LAAAEEALLLLVELAALLLLLLLQAIANASLLLIALASVVAALLELASILALQAAL 353
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
315-422 |
2.41e-03 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 40.20 E-value: 2.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 315 LDMRLMSRVLDNLLNNALRYSRTT------VQVSLLLDGSQATLIVEDDGPGIEADARERIFEPFVRldpSRDRATGGCG 388
Cdd:PRK15053 428 LDSTEFAAIVGNLLDNAFEASLRSdegnkiVELFLSDEGDDVVIEVADQGCGVPESLRDKIFEQGVS---TRADEPGEHG 504
|
90 100 110
....*....|....*....|....*....|....
gi 1185626239 389 LGLAIVHSIALAMGGSVVCDESELGGAKFSFRWP 422
Cdd:PRK15053 505 IGLYLIASYVTRCGGVITLEDNDPCGTLFSIFIP 538
|
|
| HATPase_c_2 |
pfam13581 |
Histidine kinase-like ATPase domain; |
314-398 |
4.97e-03 |
|
Histidine kinase-like ATPase domain;
Pssm-ID: 433327 [Multi-domain] Cd Length: 127 Bit Score: 36.88 E-value: 4.97e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185626239 314 ALDMRLmsrVLDNLLNNALRYSR-----TTVQVSLLLDGSQATLIVEDDGPGIEADARERifepfvRLDPSRDRATGGCG 388
Cdd:pfam13581 29 LDEVEL---AVGEACTNAVEHAYregpeGPVEVRLTSDGGGLVVTVADSGPPFDPLTLPP------PDLEEPDEDRKEGG 99
|
90
....*....|
gi 1185626239 389 LGLAIVHSIA 398
Cdd:pfam13581 100 RGLALIRGLM 109
|
|
| |
