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Conserved domains on  [gi|1185608936|gb|OSJ65415|]
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fumarate hydratase FumA, partial [Salmonella enterica subsp. enterica serovar Newport str. SHSN004]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK15389 super family cl36485
fumarate hydratase; Provisional
 1-71 1.16e-57

fumarate hydratase; Provisional


The actual alignment was detected with superfamily member PRK15389:

Pssm-ID: 237955 [Multi-domain]  Cd Length: 536  Bit Score: 184.34  E-value: 1.16e-57
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1185608936   1 SQQVTDACKKHGGFYLGSIGGPAAVLAQGSIKRLECVEYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQ 71
Cdd:PRK15389  466 SQQVTDACKKHGGFYLGSIGGPAARLAQDCIKKVEVLEYPELGMEAVWKIEVEDFPAFILVDDKGNDFFKE 536
 
Name Accession Description Interval E-value
PRK15389 PRK15389
fumarate hydratase; Provisional
 1-71 1.16e-57

fumarate hydratase; Provisional


Pssm-ID: 237955 [Multi-domain]  Cd Length: 536  Bit Score: 184.34  E-value: 1.16e-57
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1185608936   1 SQQVTDACKKHGGFYLGSIGGPAAVLAQGSIKRLECVEYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQ 71
Cdd:PRK15389  466 SQQVTDACKKHGGFYLGSIGGPAARLAQDCIKKVEVLEYPELGMEAVWKIEVEDFPAFILVDDKGNDFFKE 536
Fumerase_C pfam05683
Fumarase C-terminus; This family consists of the C terminal region of several bacterial ...
 1-71 7.37e-48

Fumarase C-terminus; This family consists of the C terminal region of several bacterial fumarate hydratase proteins (FumA and FumB). Fumarase, or fumarate hydratase (EC 4.2.1.2), is a component of the citric acid cycle. In facultative anaerobes such as Escherichia coli, fumarase also engages in the reductive pathway from oxaloacetate to succinate during anaerobic growth.


Pssm-ID: 461714 [Multi-domain]  Cd Length: 204  Bit Score: 150.32  E-value: 7.37e-48
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1185608936   1 SQQVTDACKKHGGFYLGSIGGpAAVLAQGSIKRLECVEYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQ 71
Cdd:pfam05683 135 GPAVTEACKKHGGFYLGAIGG-AAYLAAKAIKKVEVVAFEELGMEAIWEFEVEDFPAFVAVDDKGNSFHKT 204
FumA COG1838
Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain [Energy ...
 1-80 1.06e-42

Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain [Energy production and conversion]; Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 441443  Cd Length: 190  Bit Score: 136.78  E-value: 1.06e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185608936   1 SQQVTDACKKHGGFYLGSIGGPAAVLAQgSIKRLECVEYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQIQSSQCARC 80
Cdd:COG1838   108 SPEVIEAMKKHGAVYLAAVGGAAALLAK-AIKKVEVVAYEDLGPEAIWKLEVEDFPLIVAIDSKGNSLYEQGRAKARARL 186
ttdB_fumA_fumB TIGR00723
hydro-lyases, Fe-S type, tartrate/fumarate subfamily, beta region; A number of Fe-S ...
 1-71 3.07e-32

hydro-lyases, Fe-S type, tartrate/fumarate subfamily, beta region; A number of Fe-S cluster-containing hydro-lyases share a conserved motif, including argininosuccinate lyase, adenylosuccinate lyase, aspartase, class I fumarate hydratase (fumarase), and tartrate dehydratase (see PROSITE:PDOC00147). This model represents a subset of closely related proteins or modules, including the E. coli tartrate dehydratase beta chain and the C-terminal region of the class I fumarase (where the N-terminal region is homologous to the tartrate dehydratase alpha chain). The activity of archaeal proteins in this subfamily has not been established.


Pssm-ID: 129806  Cd Length: 168  Bit Score: 109.45  E-value: 3.07e-32
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1185608936   1 SQQVTDACKKHGGFYLGSIGGPAAVLAQgSIKRLECVEYPELGM-EAIWKIEVEDF-PAFILVDDKGNDFFQQ 71
Cdd:TIGR00723  97 SKEVVEACRKYKAVYLAFPGGCAALLAQ-SVKKVEGVAWEDLGMpEAIWELEVEDFgPLIVAIDSHGNSIFQE 168
 
Name Accession Description Interval E-value
PRK15389 PRK15389
fumarate hydratase; Provisional
 1-71 1.16e-57

fumarate hydratase; Provisional


Pssm-ID: 237955 [Multi-domain]  Cd Length: 536  Bit Score: 184.34  E-value: 1.16e-57
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1185608936   1 SQQVTDACKKHGGFYLGSIGGPAAVLAQGSIKRLECVEYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQ 71
Cdd:PRK15389  466 SQQVTDACKKHGGFYLGSIGGPAARLAQDCIKKVEVLEYPELGMEAVWKIEVEDFPAFILVDDKGNDFFKE 536
PRK15390 PRK15390
fumarate hydratase FumA; Provisional
 1-82 1.53e-57

fumarate hydratase FumA; Provisional


Pssm-ID: 185288 [Multi-domain]  Cd Length: 548  Bit Score: 184.47  E-value: 1.53e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185608936   1 SQQVTDACKKHGGFYLGSIGGPAAVLAQGSIKRLECVEYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQIQSSQCARC 80
Cdd:PRK15390  467 SQQVTDACKKHGGFYLGSIGGPAAVLAQGSIKSLECVEYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQIQLTQCTRC 546


                  ..
gi 1185608936  81 VK 82
Cdd:PRK15390  547 VK 548
PRK15391 PRK15391
class I fumarate hydratase;
1-82 1.79e-56

class I fumarate hydratase;


Pssm-ID: 185289 [Multi-domain]  Cd Length: 548  Bit Score: 181.38  E-value: 1.79e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185608936   1 SQQVTDACKKHGGFYLGSIGGPAAVLAQGSIKRLECVEYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQIQSSQCARC 80
Cdd:PRK15391  467 SQQVTDACHKHGGFYLGSIGGPAAVLAQQSIKHLECVAYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQIVNKQCANC 546


                  ..
gi 1185608936  81 VK 82
Cdd:PRK15391  547 TK 548
PTZ00226 PTZ00226
fumarate hydratase; Provisional
 1-71 1.17e-49

fumarate hydratase; Provisional


Pssm-ID: 240319 [Multi-domain]  Cd Length: 570  Bit Score: 163.67  E-value: 1.17e-49
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1185608936   1 SQQVTDACKKHGGFYLGSIGGPAAVLAQGSIKRLECVEYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQ 71
Cdd:PTZ00226  497 SKAVTNACKKYGGFYLGSIGGPAAILAKDNIKKVEVLDFPELGMEAVWKIEVENFPAFIVVDDKGNDFYSQ 567
Fumerase_C pfam05683
Fumarase C-terminus; This family consists of the C terminal region of several bacterial ...
 1-71 7.37e-48

Fumarase C-terminus; This family consists of the C terminal region of several bacterial fumarate hydratase proteins (FumA and FumB). Fumarase, or fumarate hydratase (EC 4.2.1.2), is a component of the citric acid cycle. In facultative anaerobes such as Escherichia coli, fumarase also engages in the reductive pathway from oxaloacetate to succinate during anaerobic growth.


Pssm-ID: 461714 [Multi-domain]  Cd Length: 204  Bit Score: 150.32  E-value: 7.37e-48
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1185608936   1 SQQVTDACKKHGGFYLGSIGGpAAVLAQGSIKRLECVEYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQ 71
Cdd:pfam05683 135 GPAVTEACKKHGGFYLGAIGG-AAYLAAKAIKKVEVVAFEELGMEAIWEFEVEDFPAFVAVDDKGNSFHKT 204
PLN00133 PLN00133
class I-fumerate hydratase; Provisional
 1-73 6.56e-45

class I-fumerate hydratase; Provisional


Pssm-ID: 215068 [Multi-domain]  Cd Length: 576  Bit Score: 151.18  E-value: 6.56e-45
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1185608936   1 SQQVTDACKKHGGFYLGSIGGPAAVLAQGSIKRLECVEYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQIQ 73
Cdd:PLN00133  503 SAQVTNACKKHGGFYLGSIGGPAAILAQNCIKKVEVLENPELGMEAVWKIEVEDFPAFIVVDDKGNDFFKKWQ 575
FumA COG1838
Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain [Energy ...
 1-80 1.06e-42

Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain [Energy production and conversion]; Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 441443  Cd Length: 190  Bit Score: 136.78  E-value: 1.06e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185608936   1 SQQVTDACKKHGGFYLGSIGGPAAVLAQgSIKRLECVEYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQIQSSQCARC 80
Cdd:COG1838   108 SPEVIEAMKKHGAVYLAAVGGAAALLAK-AIKKVEVVAYEDLGPEAIWKLEVEDFPLIVAIDSKGNSLYEQGRAKARARL 186
PRK15392 PRK15392
class I fumarate hydratase;
1-80 5.36e-41

class I fumarate hydratase;


Pssm-ID: 185290 [Multi-domain]  Cd Length: 550  Bit Score: 140.53  E-value: 5.36e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185608936   1 SQQVTDACKKHGGFYLGSIGGPAAVLAQGSIKRLECVEYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQI-QSSQCAR 79
Cdd:PRK15392  466 SQQVTDACHKHGGFNLGSIGGAAALLAQEYVKSLRCLEYPELGMEAVWMMEVENLPAFILVDDKGNNFFSQFeQQHRCAS 545


                  .
gi 1185608936  80 C 80
Cdd:PRK15392  546 C 546
ttdB_fumA_fumB TIGR00723
hydro-lyases, Fe-S type, tartrate/fumarate subfamily, beta region; A number of Fe-S ...
 1-71 3.07e-32

hydro-lyases, Fe-S type, tartrate/fumarate subfamily, beta region; A number of Fe-S cluster-containing hydro-lyases share a conserved motif, including argininosuccinate lyase, adenylosuccinate lyase, aspartase, class I fumarate hydratase (fumarase), and tartrate dehydratase (see PROSITE:PDOC00147). This model represents a subset of closely related proteins or modules, including the E. coli tartrate dehydratase beta chain and the C-terminal region of the class I fumarase (where the N-terminal region is homologous to the tartrate dehydratase alpha chain). The activity of archaeal proteins in this subfamily has not been established.


Pssm-ID: 129806  Cd Length: 168  Bit Score: 109.45  E-value: 3.07e-32
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1185608936   1 SQQVTDACKKHGGFYLGSIGGPAAVLAQgSIKRLECVEYPELGM-EAIWKIEVEDF-PAFILVDDKGNDFFQQ 71
Cdd:TIGR00723  97 SKEVVEACRKYKAVYLAFPGGCAALLAQ-SVKKVEGVAWEDLGMpEAIWELEVEDFgPLIVAIDSHGNSIFQE 168
PRK06842 PRK06842
Fe-S-containing hydro-lyase;
1-70 6.58e-20

Fe-S-containing hydro-lyase;


Pssm-ID: 180724 [Multi-domain]  Cd Length: 185  Bit Score: 78.29  E-value: 6.58e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1185608936   1 SQQVTDACKKHGGFYLGSIGGPAAVLAQgSIKRLECVEYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQ 70
Cdd:PRK06842  106 SDEVIESIKKNKAVYFGAIGGAAALIAK-SIKKSEVIAYEDLGAEAIRKLEVKDFPVVVIIDSEGNNLYE 174
PRK06043 PRK06043
fumarate hydratase; Provisional
 2-73 4.38e-13

fumarate hydratase; Provisional


Pssm-ID: 180366  Cd Length: 192  Bit Score: 60.93  E-value: 4.38e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1185608936   2 QQVTDACKKhGGFYLGSIGGPAAvLAQGSIKRLECVEYPELGM-EAIWKIEVEDF-PAFILVDDKGNDFFQQIQ 73
Cdd:PRK06043  109 KNVADALKG-KCVYLAYTGGCAA-LAAESIKRVKAVHWLDLGMpEAVWVLEVEEFgPLIVGIDAKGNDLYSEVR 180
PRK08395 PRK08395
fumarate hydratase; Provisional
 15-70 4.35e-09

fumarate hydratase; Provisional


Pssm-ID: 169425  Cd Length: 162  Bit Score: 49.81  E-value: 4.35e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1185608936  15 YLGSIGGpAAVLAQGSIKRLECVEYPELGM-EAIWKIEVEDFPAFILVDDKGNDFFQ 70
Cdd:PRK08395  107 YFAFPGG-AGSLAAKSIKRVRDVYWEDLGMpDAVWELEVEDFPLLVAIDSKGRSLYR 162
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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