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Conserved domains on  [gi|1132414585|gb|OLY77768|]
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Importin subunit beta-3 [Smittium mucronatum]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Importin_rep_4 pfam18808
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem ...
278-367 8.29e-44

Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry includes a single repeat unit.


:

Pssm-ID: 408579  Cd Length: 90  Bit Score: 153.39  E-value: 8.29e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132414585  278 NKNLMDATRQVALEVLITLAEAAPGLCRKQSHFCEKLVPVILDMMTEIQDDEDWYAVDSLDEDDEEDNSVFGEQAIDRLA 357
Cdd:pfam18808    1 NKDLDDAARQVALELLVTLAEAAPGMCRKQPQFTNALVPICLSMMTEVDDAEDWYTSDDLDDDDNEDNYVFGEQALDRLA 80
                           90
                   ....*....|
gi 1132414585  358 CSLGGKQMLP 367
Cdd:pfam18808   81 CRLGGKALLP 90
Importin_rep_6 pfam18829
Importin repeat 6; The importin subunit beta-3 has a superhelical structure composed of tandem ...
782-892 2.38e-29

Importin repeat 6; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry represents two consecutive repeat units and includes sequences captured by pfam18808.


:

Pssm-ID: 465881  Cd Length: 110  Bit Score: 112.97  E-value: 2.38e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132414585  782 FVSQLFSSFADSVEVAGEGCLNNVQLQEFISVVNRILNLNLKQIEERQIQFNSGEgVDEEEARIIGEDEIAESEAMDSIS 861
Cdd:pfam18829    1 VLAEYYSSLAECIEVLGPNCLSDEQMEEFIKAINSNLTEYFERVKEREEERKDDD-YDEEVEEDLEEEEETDEELLSEIN 79
                           90       100       110
                   ....*....|....*....|....*....|.
gi 1132414585  862 KALRLVLKTNTSSFIGLFDQLIPTLVMFADP 892
Cdd:pfam18829   80 KAIHAIFKTHKTAFLPYFEQLLPTVVAFLND 110
KAP95 super family cl27231
Karyopherin (importin) beta [Intracellular trafficking and secretion];
14-638 3.26e-18

Karyopherin (importin) beta [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5215:

Pssm-ID: 227540 [Multi-domain]  Cd Length: 858  Bit Score: 90.38  E-value: 3.26e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132414585   14 ILQNlmeNLLSPNNEIRTQAEKTLNTEWS--IAQPKSLLIglSLIMNESPDPNIRGFASVLLRRVSLKEDfnSNGNQDYp 91
Cdd:COG5215      9 LGKN---HVLSPDPNARLRAEAQLLELQSgdFEQFISLLV--QVLCDLNSNDQLRMVAGLILKNSLHAND--PELQKGC- 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132414585   92 dTSVWVRVNDESRNQVKSLLLSALnretdSGSRNKICDT----ISDIANYD---DKWPELLGTLF--ICASSEIPSHRES 162
Cdd:COG5215     81 -SQRWLGMRHESKEQVKGMALRAL-----KSPEPRFCTMaaqlLAAIARMElpnSLWPGLMEEMVrnVGDEQPVSGKCES 154
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132414585  163 AYRIFYGC----PQLLADQNPQSVRDAFIGAFQD-PVNNVRLAALKAAVQVLMISQDKYRSKFDsmVPHMLSVLEPLVSL 237
Cdd:COG5215    155 LGICGYHCeseaPEDLIQMSNVILFAIVMGALKNeTTSAVRLAALKALMDSLMFVQGNFCYEEE--RNYFMQVVCEATQG 232
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132414585  238 NDEQSLVECLSALSELAEVYPKAFRPILVNMLdLGALIGGNKNLMDATRQVALEVLITLAEA----------APGLCRKQ 307
Cdd:COG5215    233 NDEELQHAAFGCLNKIMMLYYKFMQSYMENAL-AALTGRFMKSQNDEVAIQAVEFWSTICEEeidgemedkyLPEVPAQN 311
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132414585  308 SHFC----EKLVPVILDMMT---EIQDDEDWyavdsldeddeedNSVFGEQAIDRLACSLGGKQMLPVAFQHIPTMLSSQ 380
Cdd:COG5215    312 HGFAraavADVLPELLSLLEkqgEDYYGDDW-------------NPSMAASSCLQLFAQLKGDKIMRPVLGFVEQNIRSE 378
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132414585  381 EWQRRHAALMAISAIGEGSFKIMKNE--------LENILNIVC------------------PYIRDP------------- 421
Cdd:COG5215    379 SWANREAAVMAFGSVMHGPCEDCLTKivpqalpgIENEMSDSClwvksttawcfgaiadhvAMIISPcghlvlevsasli 458
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132414585  422 ----HPRIRYAACNAIGQISTDFSPTVQE------KFHSIVLQSLIPAMDDV---SNPRVQAHAA-AAMVNFCEEA---- 483
Cdd:COG5215    459 glmdCPFRSINCSWRKENLVDHIAKAVREvesflaKFYLAILNALVKGTELAlneSNLRVSLFSAlGTLILICPDAvsdi 538
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132414585  484 ------------------------------------------------RKKTIEPYLDTLFERLMKLL-TSDKRYVQEQA 514
Cdd:COG5215    539 lagfydytskkldecisvlgqilatedqllveelqsnyigvleaiirtRRRDIEDVEDQLMELFIRILeSTKPTTAFGDV 618
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132414585  515 ITTIATVADSAQELFRKHYSAIVPQLLNVLenaSEKEYRLLrGKAIECASFIALAVGYDvFKTDAPKFIDLLVKTQSQVV 594
Cdd:COG5215    619 YTAISALSTSLEERFEQYASKFIPYLTRAL---NCTDRFVL-NSAVGLVGDLANTLGTD-FNIYADVLMSSLVQCLSSEA 693
                          730       740       750       760
                   ....*....|....*....|....*....|....*....|....*.
gi 1132414585  595 EDDD--PQIsylLAAWARLCKVMGQDFIPYLPVVMPPLLKSASLQP 638
Cdd:COG5215    694 THRDlkPAI---LSVFGDIALAIGANFESYLDMIMMLFQQASELDP 736
 
Name Accession Description Interval E-value
Importin_rep_4 pfam18808
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem ...
278-367 8.29e-44

Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry includes a single repeat unit.


Pssm-ID: 408579  Cd Length: 90  Bit Score: 153.39  E-value: 8.29e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132414585  278 NKNLMDATRQVALEVLITLAEAAPGLCRKQSHFCEKLVPVILDMMTEIQDDEDWYAVDSLDEDDEEDNSVFGEQAIDRLA 357
Cdd:pfam18808    1 NKDLDDAARQVALELLVTLAEAAPGMCRKQPQFTNALVPICLSMMTEVDDAEDWYTSDDLDDDDNEDNYVFGEQALDRLA 80
                           90
                   ....*....|
gi 1132414585  358 CSLGGKQMLP 367
Cdd:pfam18808   81 CRLGGKALLP 90
Importin_rep_6 pfam18829
Importin repeat 6; The importin subunit beta-3 has a superhelical structure composed of tandem ...
782-892 2.38e-29

Importin repeat 6; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry represents two consecutive repeat units and includes sequences captured by pfam18808.


Pssm-ID: 465881  Cd Length: 110  Bit Score: 112.97  E-value: 2.38e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132414585  782 FVSQLFSSFADSVEVAGEGCLNNVQLQEFISVVNRILNLNLKQIEERQIQFNSGEgVDEEEARIIGEDEIAESEAMDSIS 861
Cdd:pfam18829    1 VLAEYYSSLAECIEVLGPNCLSDEQMEEFIKAINSNLTEYFERVKEREEERKDDD-YDEEVEEDLEEEEETDEELLSEIN 79
                           90       100       110
                   ....*....|....*....|....*....|.
gi 1132414585  862 KALRLVLKTNTSSFIGLFDQLIPTLVMFADP 892
Cdd:pfam18829   80 KAIHAIFKTHKTAFLPYFEQLLPTVVAFLND 110
KAP95 COG5215
Karyopherin (importin) beta [Intracellular trafficking and secretion];
14-638 3.26e-18

Karyopherin (importin) beta [Intracellular trafficking and secretion];


Pssm-ID: 227540 [Multi-domain]  Cd Length: 858  Bit Score: 90.38  E-value: 3.26e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132414585   14 ILQNlmeNLLSPNNEIRTQAEKTLNTEWS--IAQPKSLLIglSLIMNESPDPNIRGFASVLLRRVSLKEDfnSNGNQDYp 91
Cdd:COG5215      9 LGKN---HVLSPDPNARLRAEAQLLELQSgdFEQFISLLV--QVLCDLNSNDQLRMVAGLILKNSLHAND--PELQKGC- 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132414585   92 dTSVWVRVNDESRNQVKSLLLSALnretdSGSRNKICDT----ISDIANYD---DKWPELLGTLF--ICASSEIPSHRES 162
Cdd:COG5215     81 -SQRWLGMRHESKEQVKGMALRAL-----KSPEPRFCTMaaqlLAAIARMElpnSLWPGLMEEMVrnVGDEQPVSGKCES 154
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132414585  163 AYRIFYGC----PQLLADQNPQSVRDAFIGAFQD-PVNNVRLAALKAAVQVLMISQDKYRSKFDsmVPHMLSVLEPLVSL 237
Cdd:COG5215    155 LGICGYHCeseaPEDLIQMSNVILFAIVMGALKNeTTSAVRLAALKALMDSLMFVQGNFCYEEE--RNYFMQVVCEATQG 232
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132414585  238 NDEQSLVECLSALSELAEVYPKAFRPILVNMLdLGALIGGNKNLMDATRQVALEVLITLAEA----------APGLCRKQ 307
Cdd:COG5215    233 NDEELQHAAFGCLNKIMMLYYKFMQSYMENAL-AALTGRFMKSQNDEVAIQAVEFWSTICEEeidgemedkyLPEVPAQN 311
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132414585  308 SHFC----EKLVPVILDMMT---EIQDDEDWyavdsldeddeedNSVFGEQAIDRLACSLGGKQMLPVAFQHIPTMLSSQ 380
Cdd:COG5215    312 HGFAraavADVLPELLSLLEkqgEDYYGDDW-------------NPSMAASSCLQLFAQLKGDKIMRPVLGFVEQNIRSE 378
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132414585  381 EWQRRHAALMAISAIGEGSFKIMKNE--------LENILNIVC------------------PYIRDP------------- 421
Cdd:COG5215    379 SWANREAAVMAFGSVMHGPCEDCLTKivpqalpgIENEMSDSClwvksttawcfgaiadhvAMIISPcghlvlevsasli 458
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132414585  422 ----HPRIRYAACNAIGQISTDFSPTVQE------KFHSIVLQSLIPAMDDV---SNPRVQAHAA-AAMVNFCEEA---- 483
Cdd:COG5215    459 glmdCPFRSINCSWRKENLVDHIAKAVREvesflaKFYLAILNALVKGTELAlneSNLRVSLFSAlGTLILICPDAvsdi 538
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132414585  484 ------------------------------------------------RKKTIEPYLDTLFERLMKLL-TSDKRYVQEQA 514
Cdd:COG5215    539 lagfydytskkldecisvlgqilatedqllveelqsnyigvleaiirtRRRDIEDVEDQLMELFIRILeSTKPTTAFGDV 618
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132414585  515 ITTIATVADSAQELFRKHYSAIVPQLLNVLenaSEKEYRLLrGKAIECASFIALAVGYDvFKTDAPKFIDLLVKTQSQVV 594
Cdd:COG5215    619 YTAISALSTSLEERFEQYASKFIPYLTRAL---NCTDRFVL-NSAVGLVGDLANTLGTD-FNIYADVLMSSLVQCLSSEA 693
                          730       740       750       760
                   ....*....|....*....|....*....|....*....|....*.
gi 1132414585  595 EDDD--PQIsylLAAWARLCKVMGQDFIPYLPVVMPPLLKSASLQP 638
Cdd:COG5215    694 THRDlkPAI---LSVFGDIALAIGANFESYLDMIMMLFQQASELDP 736
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
382-436 6.72e-08

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 50.06  E-value: 6.72e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1132414585  382 WQRRHAALMAISAIGEGSFKIMKNELENILNIVCPYIRDPHPRIRYAACNAIGQI 436
Cdd:pfam13513    1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
 
Name Accession Description Interval E-value
Importin_rep_4 pfam18808
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem ...
278-367 8.29e-44

Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry includes a single repeat unit.


Pssm-ID: 408579  Cd Length: 90  Bit Score: 153.39  E-value: 8.29e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132414585  278 NKNLMDATRQVALEVLITLAEAAPGLCRKQSHFCEKLVPVILDMMTEIQDDEDWYAVDSLDEDDEEDNSVFGEQAIDRLA 357
Cdd:pfam18808    1 NKDLDDAARQVALELLVTLAEAAPGMCRKQPQFTNALVPICLSMMTEVDDAEDWYTSDDLDDDDNEDNYVFGEQALDRLA 80
                           90
                   ....*....|
gi 1132414585  358 CSLGGKQMLP 367
Cdd:pfam18808   81 CRLGGKALLP 90
Importin_rep_6 pfam18829
Importin repeat 6; The importin subunit beta-3 has a superhelical structure composed of tandem ...
782-892 2.38e-29

Importin repeat 6; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry represents two consecutive repeat units and includes sequences captured by pfam18808.


Pssm-ID: 465881  Cd Length: 110  Bit Score: 112.97  E-value: 2.38e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132414585  782 FVSQLFSSFADSVEVAGEGCLNNVQLQEFISVVNRILNLNLKQIEERQIQFNSGEgVDEEEARIIGEDEIAESEAMDSIS 861
Cdd:pfam18829    1 VLAEYYSSLAECIEVLGPNCLSDEQMEEFIKAINSNLTEYFERVKEREEERKDDD-YDEEVEEDLEEEEETDEELLSEIN 79
                           90       100       110
                   ....*....|....*....|....*....|.
gi 1132414585  862 KALRLVLKTNTSSFIGLFDQLIPTLVMFADP 892
Cdd:pfam18829   80 KAIHAIFKTHKTAFLPYFEQLLPTVVAFLND 110
KAP95 COG5215
Karyopherin (importin) beta [Intracellular trafficking and secretion];
14-638 3.26e-18

Karyopherin (importin) beta [Intracellular trafficking and secretion];


Pssm-ID: 227540 [Multi-domain]  Cd Length: 858  Bit Score: 90.38  E-value: 3.26e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132414585   14 ILQNlmeNLLSPNNEIRTQAEKTLNTEWS--IAQPKSLLIglSLIMNESPDPNIRGFASVLLRRVSLKEDfnSNGNQDYp 91
Cdd:COG5215      9 LGKN---HVLSPDPNARLRAEAQLLELQSgdFEQFISLLV--QVLCDLNSNDQLRMVAGLILKNSLHAND--PELQKGC- 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132414585   92 dTSVWVRVNDESRNQVKSLLLSALnretdSGSRNKICDT----ISDIANYD---DKWPELLGTLF--ICASSEIPSHRES 162
Cdd:COG5215     81 -SQRWLGMRHESKEQVKGMALRAL-----KSPEPRFCTMaaqlLAAIARMElpnSLWPGLMEEMVrnVGDEQPVSGKCES 154
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132414585  163 AYRIFYGC----PQLLADQNPQSVRDAFIGAFQD-PVNNVRLAALKAAVQVLMISQDKYRSKFDsmVPHMLSVLEPLVSL 237
Cdd:COG5215    155 LGICGYHCeseaPEDLIQMSNVILFAIVMGALKNeTTSAVRLAALKALMDSLMFVQGNFCYEEE--RNYFMQVVCEATQG 232
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132414585  238 NDEQSLVECLSALSELAEVYPKAFRPILVNMLdLGALIGGNKNLMDATRQVALEVLITLAEA----------APGLCRKQ 307
Cdd:COG5215    233 NDEELQHAAFGCLNKIMMLYYKFMQSYMENAL-AALTGRFMKSQNDEVAIQAVEFWSTICEEeidgemedkyLPEVPAQN 311
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132414585  308 SHFC----EKLVPVILDMMT---EIQDDEDWyavdsldeddeedNSVFGEQAIDRLACSLGGKQMLPVAFQHIPTMLSSQ 380
Cdd:COG5215    312 HGFAraavADVLPELLSLLEkqgEDYYGDDW-------------NPSMAASSCLQLFAQLKGDKIMRPVLGFVEQNIRSE 378
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132414585  381 EWQRRHAALMAISAIGEGSFKIMKNE--------LENILNIVC------------------PYIRDP------------- 421
Cdd:COG5215    379 SWANREAAVMAFGSVMHGPCEDCLTKivpqalpgIENEMSDSClwvksttawcfgaiadhvAMIISPcghlvlevsasli 458
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132414585  422 ----HPRIRYAACNAIGQISTDFSPTVQE------KFHSIVLQSLIPAMDDV---SNPRVQAHAA-AAMVNFCEEA---- 483
Cdd:COG5215    459 glmdCPFRSINCSWRKENLVDHIAKAVREvesflaKFYLAILNALVKGTELAlneSNLRVSLFSAlGTLILICPDAvsdi 538
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132414585  484 ------------------------------------------------RKKTIEPYLDTLFERLMKLL-TSDKRYVQEQA 514
Cdd:COG5215    539 lagfydytskkldecisvlgqilatedqllveelqsnyigvleaiirtRRRDIEDVEDQLMELFIRILeSTKPTTAFGDV 618
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132414585  515 ITTIATVADSAQELFRKHYSAIVPQLLNVLenaSEKEYRLLrGKAIECASFIALAVGYDvFKTDAPKFIDLLVKTQSQVV 594
Cdd:COG5215    619 YTAISALSTSLEERFEQYASKFIPYLTRAL---NCTDRFVL-NSAVGLVGDLANTLGTD-FNIYADVLMSSLVQCLSSEA 693
                          730       740       750       760
                   ....*....|....*....|....*....|....*....|....*.
gi 1132414585  595 EDDD--PQIsylLAAWARLCKVMGQDFIPYLPVVMPPLLKSASLQP 638
Cdd:COG5215    694 THRDlkPAI---LSVFGDIALAIGANFESYLDMIMMLFQQASELDP 736
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
382-436 6.72e-08

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 50.06  E-value: 6.72e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1132414585  382 WQRRHAALMAISAIGEGSFKIMKNELENILNIVCPYIRDPHPRIRYAACNAIGQI 436
Cdd:pfam13513    1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
373-476 1.65e-05

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 44.25  E-value: 1.65e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132414585  373 IPTMLSSQEWQRRHAALMAISAIGEgsfkimknelENILNIVCPYIRDPHPRIRYAACNAIGQISTdfsptvqekfhSIV 452
Cdd:pfam13646    5 LQALLRDPDPEVRAAAIRALGRIGD----------PEAVPALLELLKDEDPAVRRAAAEALGKIGD-----------PEA 63
                           90       100
                   ....*....|....*....|....
gi 1132414585  453 LQSLIPAMDDVSNPRVQAHAAAAM 476
Cdd:pfam13646   64 LPALLELLRDDDDDVVRAAAAEAL 87
HEAT COG1413
HEAT repeat [General function prediction only];
385-549 2.97e-05

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 45.00  E-value: 2.97e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132414585  385 RHAALMAISAIGEgsfkimknelENILNIVCPYIRDPHPRIRYAACNAIGQIStdfsptvqekfHSIVLQSLIPAMDDvS 464
Cdd:COG1413      2 RRAAARALGRLGD----------PAAVPALIAALADEDPDVRAAAARALGRLG-----------DPRAVPALLEALKD-P 59
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132414585  465 NPRVQAHAAAAMVNF-CEEArkktiepyldtlFERLMKLLTSDKRYVQEQAITTIATVADsaqelfrkhySAIVPQLLNV 543
Cdd:COG1413     60 DPEVRAAAAEALGRIgDPEA------------VPALIAALKDEDPEVRRAAAEALGRLGD----------PAAVPALLEA 117

                   ....*.
gi 1132414585  544 LENASE 549
Cdd:COG1413    118 LKDPDW 123
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
466-521 2.15e-04

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 40.04  E-value: 2.15e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1132414585  466 PRVQAHAAAAMVNfCEEARKKTIEPYLDTLFERLMKLLTSDKRYVQEQAITTIATV 521
Cdd:pfam13513    1 WRVREAAALALGS-LAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
MMS19_C pfam12460
RNAPII transcription regulator C-terminal; MMS19 is required for both nucleotide excision ...
447-562 1.22e-03

RNAPII transcription regulator C-terminal; MMS19 is required for both nucleotide excision repair (NER) and RNA polymerase II (RNAP II) transcription. This C-terminal domain, along with the N-terminal, MMS19_N, form part of a silencing complex in fission yeast that contains Dos2, Rik1, Mms19 and Cdc20 (the catalytic subunit of DNA polymerase-epsilon). This complex regulates RNA polymerase II (RNA Pol II) activity in heterochromatin and is required for DNA replication and heterochromatin assembly. This domain has a HEAT-like repeat structure.


Pssm-ID: 463594  Cd Length: 426  Bit Score: 42.63  E-value: 1.22e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132414585  447 KFHSIVLQSLIPAMDDVSNPRVQAHAAAAMVNFCEEARKKTIEPYLDTLFERLMKLLTSDKRYVQEQAITTIATVADSAQ 526
Cdd:pfam12460  307 RFFNTVLPKLVEGFKSADDSSIKPNYLTALSLILKNVPKSLLLPELPTLLPLLLQALDLPDAEVRLSTLETLLSLLEEAP 386
                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1132414585  527 ELFRKHYSAIVPQLLNVLENASEKEYRlLRGKAIEC 562
Cdd:pfam12460  387 QLVSEHLSSLVPRLLKLSTPSSMNSAK-VRIAALQC 421
HEAT pfam02985
HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see ...
410-437 1.74e-03

HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514).


Pssm-ID: 460773  Cd Length: 31  Bit Score: 36.74  E-value: 1.74e-03
                           10        20
                   ....*....|....*....|....*...
gi 1132414585  410 ILNIVCPYIRDPHPRIRYAACNAIGQIS 437
Cdd:pfam02985    1 LLPLLLKLLNDPSPEVREAAAEALGELA 28
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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