|
Name |
Accession |
Description |
Interval |
E-value |
| murB |
PRK00046 |
UDP-N-acetylmuramate dehydrogenase; |
1-329 |
0e+00 |
|
UDP-N-acetylmuramate dehydrogenase;
Pssm-ID: 234593 [Multi-domain] Cd Length: 334 Bit Score: 651.06 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123158524 1 MNHSLKPWNTFGIDHNAQHIVCAEDEQQLLNAWQHATAEGQPVLILGEGSNVLFLEDYRGTVIINRIKGIEI-HDEPDAW 79
Cdd:PRK00046 5 MNHSLKPLNTFGIDARARHLVEAESEEQLLEALADARAAGLPVLVLGGGSNVLFTEDFDGTVLLNRIKGIEVlSEDDDAW 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123158524 80 YLHVGAGENWHRLVKYTLQEGMPGLENLALIPGCVGSSPIQNIGAYGVELQRVCAYVDCVELATGKQVRLTAKECRFGYR 159
Cdd:PRK00046 85 YLHVGAGENWHDLVLWTLQQGMPGLENLALIPGTVGAAPIQNIGAYGVELKDVCDYVEALDLATGEFVRLSAAECRFGYR 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123158524 160 DSIFKHEYQDRFAIVAVGLRLPKEWQPVLTYGDLTRLDPTTVTPQQVFDAVCHMRTTKLPDPKVNGNAGSFFKNPVVSAE 239
Cdd:PRK00046 165 DSIFKHEYPDRYAITAVGFRLPKQWQPVLDYGDLARLDPDTVTAQDVFDAVCAIRRSKLPDPKVLGNAGSFFKNPVVSAE 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123158524 240 TAKALLAQFPTAPNYPQTDGSVKLAAGWLIDQCQLKGTQIGGAAVHRQQALVLINEGNAKSEDIVQLAHHVRQKVGEKFN 319
Cdd:PRK00046 245 QFEALLAQYPDIPHYPQADGSVKLAAGWLIDQCGLKGFQIGGAAVHEKQALVLVNYGNATGADVLALARHIQQDVREKFG 324
|
330
....*....|
gi 1123158524 320 VWLEPEVRFI 329
Cdd:PRK00046 325 VELEPEPRFI 334
|
|
| murB |
TIGR00179 |
UDP-N-acetylenolpyruvoylglucosamine reductase; This model describes MurB, ... |
5-330 |
4.43e-156 |
|
UDP-N-acetylenolpyruvoylglucosamine reductase; This model describes MurB, UDP-N-acetylenolpyruvoylglucosamine reductase, which is also called UDP-N-acetylmuramate dehydrogenase. It is part of the pathway for the biosynthesis of the UDP-N-acetylmuramoyl-pentapeptide that is a precursor of bacterial peptidoglycan. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 272945 [Multi-domain] Cd Length: 284 Bit Score: 438.81 E-value: 4.43e-156
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123158524 5 LKPWNTFGIDHNAQHIVCAEDEQQLLNAWQHATAEGQPVLILGEGSNVLFLEDYRGTVIINRIKGIEIHDEPdAWYLHVG 84
Cdd:TIGR00179 1 LAEFTTYKIGGNARHIVCPESIEQLVNVLDNAKEEDQPLLILGEGSNLLILDDGRGGVIINLGKGIDIEDDE-GEYVHVG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123158524 85 AGENWHRLVKYTLQEGMPGLENLALIPGCVGSSPIQNIGAYGVELQRVCAYVdCVELATGKQVRLTAKECRFGYRDSIFK 164
Cdd:TIGR00179 80 GGENWHKLVKYALKNGLSGLEFLAGIPGTVGGAVIMNAGAYGVEISEVLVYA-TILLATGKTEWLTNEQLGFGYRTSIFQ 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123158524 165 HEYqdrfaivaVGLRLPKEWQPVLTYGdlTRLDPTTVTPQQVFDAVCHMRTTKLPDPkvngNAGSFFKNPvvsaetakal 244
Cdd:TIGR00179 159 HKY--------VGLVLKAEFQLTLGFG--TRLDPETITAQQVFNKVCRMRTSHYPDP----NAGSFFKNP---------- 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123158524 245 laqfptAPNYpqtdgsvklaAGWLIDQCQLKGTQIGGAAVHRQQALVLINEGNAKSEDIVQLAHHVRQKVGEKFNVWLEP 324
Cdd:TIGR00179 215 ------SPNH----------AGRLIEECGLKGYQIGGAAVSKQHANFLVNIDNAKSEDVLDLIEHVKAEVGEKYGILLEP 278
|
....*.
gi 1123158524 325 EVRFIG 330
Cdd:TIGR00179 279 EVKIIG 284
|
|
| MurB |
COG0812 |
UDP-N-acetylenolpyruvoylglucosamine reductase [Cell wall/membrane/envelope biogenesis]; ... |
3-329 |
3.58e-135 |
|
UDP-N-acetylenolpyruvoylglucosamine reductase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylenolpyruvoylglucosamine reductase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440574 [Multi-domain] Cd Length: 279 Bit Score: 385.52 E-value: 3.58e-135
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123158524 3 HSLKPWNTFGIDHNAQHIVCAEDEQQLLNAWQHATAEGQPVLILGEGSNVLFLED-YRGTVIINR-IKGIEIHDEpdaWY 80
Cdd:COG0812 1 EPLAPHTTFRIGGPADLLVEPASEEELAALLRAAREAGLPVLVLGGGSNLLVRDDgFDGLVIRLGrLKGIEVDDG---VL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123158524 81 LHVGAGENWHRLVKYTLQEGMPGLENLALIPGCVGSSPIQNIGAYGVELQRVCAYVDCVElATGKQVRLTAKECRFGYRD 160
Cdd:COG0812 78 VTAGAGENWHDLVRFALEAGLSGLEFLAGIPGTVGGAPVMNAGAYGGEIKDVLESVEVLD-RTGEVRTLSAEECGFGYRD 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123158524 161 SIFKHEyqdRFAIVAVGLRLPKEwqpvlTYGDLtrldpttvtpQQVFDAVCHMRTTKlpDPKVNGNAGSFFKNPvvsaet 240
Cdd:COG0812 157 SIFKRE---RYIILSVTFRLKKG-----DPAEI----------AAVMDAVLAIRRSK--QPLELPSAGSFFKNP------ 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123158524 241 akallaqfptaPNYPqtdgsvklaAGWLIDQCQLKGTQIGGAAVHRQQALVLINEGNAKSEDIVQLAHHVRQKVGEKFNV 320
Cdd:COG0812 211 -----------PGDS---------AGWLIEQAGLKGYRIGGAQVSEKHANFLVNRGGATAADVLALIEEVQARVKEKFGV 270
|
....*....
gi 1123158524 321 WLEPEVRFI 329
Cdd:COG0812 271 ELEPEVRII 279
|
|
| MurB_C |
pfam02873 |
UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Members of this family are ... |
206-329 |
5.67e-42 |
|
UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Members of this family are UDP-N-acetylenolpyruvoylglucosamine reductase enzymes EC:1.1.1.158. This enzyme is involved in the biosynthesis of peptidoglycan.
Pssm-ID: 460730 [Multi-domain] Cd Length: 99 Bit Score: 141.33 E-value: 5.67e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123158524 206 VFDAVCHMRTTKL-PDPKVNGNAGSFFKNPVvsaetakallaqfptapnypqtdgsvKLAAGWLIDQCQLKGTQIGGAAV 284
Cdd:pfam02873 1 IRAAMLELRRRRLaKQPLDPPSAGSFFKNPV--------------------------GHSAGWLIEQAGLKGYRIGGAQV 54
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 1123158524 285 HRQQALVLINEGNAKSEDIVQLAHHVRQKVGEKFNVWLEPEVRFI 329
Cdd:pfam02873 55 SEKHANFLVNTGGATAADVLALIEEVRERVKEKFGVELEPEVRII 99
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| murB |
PRK00046 |
UDP-N-acetylmuramate dehydrogenase; |
1-329 |
0e+00 |
|
UDP-N-acetylmuramate dehydrogenase;
Pssm-ID: 234593 [Multi-domain] Cd Length: 334 Bit Score: 651.06 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123158524 1 MNHSLKPWNTFGIDHNAQHIVCAEDEQQLLNAWQHATAEGQPVLILGEGSNVLFLEDYRGTVIINRIKGIEI-HDEPDAW 79
Cdd:PRK00046 5 MNHSLKPLNTFGIDARARHLVEAESEEQLLEALADARAAGLPVLVLGGGSNVLFTEDFDGTVLLNRIKGIEVlSEDDDAW 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123158524 80 YLHVGAGENWHRLVKYTLQEGMPGLENLALIPGCVGSSPIQNIGAYGVELQRVCAYVDCVELATGKQVRLTAKECRFGYR 159
Cdd:PRK00046 85 YLHVGAGENWHDLVLWTLQQGMPGLENLALIPGTVGAAPIQNIGAYGVELKDVCDYVEALDLATGEFVRLSAAECRFGYR 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123158524 160 DSIFKHEYQDRFAIVAVGLRLPKEWQPVLTYGDLTRLDPTTVTPQQVFDAVCHMRTTKLPDPKVNGNAGSFFKNPVVSAE 239
Cdd:PRK00046 165 DSIFKHEYPDRYAITAVGFRLPKQWQPVLDYGDLARLDPDTVTAQDVFDAVCAIRRSKLPDPKVLGNAGSFFKNPVVSAE 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123158524 240 TAKALLAQFPTAPNYPQTDGSVKLAAGWLIDQCQLKGTQIGGAAVHRQQALVLINEGNAKSEDIVQLAHHVRQKVGEKFN 319
Cdd:PRK00046 245 QFEALLAQYPDIPHYPQADGSVKLAAGWLIDQCGLKGFQIGGAAVHEKQALVLVNYGNATGADVLALARHIQQDVREKFG 324
|
330
....*....|
gi 1123158524 320 VWLEPEVRFI 329
Cdd:PRK00046 325 VELEPEPRFI 334
|
|
| murB |
TIGR00179 |
UDP-N-acetylenolpyruvoylglucosamine reductase; This model describes MurB, ... |
5-330 |
4.43e-156 |
|
UDP-N-acetylenolpyruvoylglucosamine reductase; This model describes MurB, UDP-N-acetylenolpyruvoylglucosamine reductase, which is also called UDP-N-acetylmuramate dehydrogenase. It is part of the pathway for the biosynthesis of the UDP-N-acetylmuramoyl-pentapeptide that is a precursor of bacterial peptidoglycan. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 272945 [Multi-domain] Cd Length: 284 Bit Score: 438.81 E-value: 4.43e-156
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123158524 5 LKPWNTFGIDHNAQHIVCAEDEQQLLNAWQHATAEGQPVLILGEGSNVLFLEDYRGTVIINRIKGIEIHDEPdAWYLHVG 84
Cdd:TIGR00179 1 LAEFTTYKIGGNARHIVCPESIEQLVNVLDNAKEEDQPLLILGEGSNLLILDDGRGGVIINLGKGIDIEDDE-GEYVHVG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123158524 85 AGENWHRLVKYTLQEGMPGLENLALIPGCVGSSPIQNIGAYGVELQRVCAYVdCVELATGKQVRLTAKECRFGYRDSIFK 164
Cdd:TIGR00179 80 GGENWHKLVKYALKNGLSGLEFLAGIPGTVGGAVIMNAGAYGVEISEVLVYA-TILLATGKTEWLTNEQLGFGYRTSIFQ 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123158524 165 HEYqdrfaivaVGLRLPKEWQPVLTYGdlTRLDPTTVTPQQVFDAVCHMRTTKLPDPkvngNAGSFFKNPvvsaetakal 244
Cdd:TIGR00179 159 HKY--------VGLVLKAEFQLTLGFG--TRLDPETITAQQVFNKVCRMRTSHYPDP----NAGSFFKNP---------- 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123158524 245 laqfptAPNYpqtdgsvklaAGWLIDQCQLKGTQIGGAAVHRQQALVLINEGNAKSEDIVQLAHHVRQKVGEKFNVWLEP 324
Cdd:TIGR00179 215 ------SPNH----------AGRLIEECGLKGYQIGGAAVSKQHANFLVNIDNAKSEDVLDLIEHVKAEVGEKYGILLEP 278
|
....*.
gi 1123158524 325 EVRFIG 330
Cdd:TIGR00179 279 EVKIIG 284
|
|
| MurB |
COG0812 |
UDP-N-acetylenolpyruvoylglucosamine reductase [Cell wall/membrane/envelope biogenesis]; ... |
3-329 |
3.58e-135 |
|
UDP-N-acetylenolpyruvoylglucosamine reductase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylenolpyruvoylglucosamine reductase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440574 [Multi-domain] Cd Length: 279 Bit Score: 385.52 E-value: 3.58e-135
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123158524 3 HSLKPWNTFGIDHNAQHIVCAEDEQQLLNAWQHATAEGQPVLILGEGSNVLFLED-YRGTVIINR-IKGIEIHDEpdaWY 80
Cdd:COG0812 1 EPLAPHTTFRIGGPADLLVEPASEEELAALLRAAREAGLPVLVLGGGSNLLVRDDgFDGLVIRLGrLKGIEVDDG---VL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123158524 81 LHVGAGENWHRLVKYTLQEGMPGLENLALIPGCVGSSPIQNIGAYGVELQRVCAYVDCVElATGKQVRLTAKECRFGYRD 160
Cdd:COG0812 78 VTAGAGENWHDLVRFALEAGLSGLEFLAGIPGTVGGAPVMNAGAYGGEIKDVLESVEVLD-RTGEVRTLSAEECGFGYRD 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123158524 161 SIFKHEyqdRFAIVAVGLRLPKEwqpvlTYGDLtrldpttvtpQQVFDAVCHMRTTKlpDPKVNGNAGSFFKNPvvsaet 240
Cdd:COG0812 157 SIFKRE---RYIILSVTFRLKKG-----DPAEI----------AAVMDAVLAIRRSK--QPLELPSAGSFFKNP------ 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123158524 241 akallaqfptaPNYPqtdgsvklaAGWLIDQCQLKGTQIGGAAVHRQQALVLINEGNAKSEDIVQLAHHVRQKVGEKFNV 320
Cdd:COG0812 211 -----------PGDS---------AGWLIEQAGLKGYRIGGAQVSEKHANFLVNRGGATAADVLALIEEVQARVKEKFGV 270
|
....*....
gi 1123158524 321 WLEPEVRFI 329
Cdd:COG0812 271 ELEPEVRII 279
|
|
| murB |
PRK13903 |
UDP-N-acetylmuramate dehydrogenase; |
4-332 |
1.53e-77 |
|
UDP-N-acetylmuramate dehydrogenase;
Pssm-ID: 237552 [Multi-domain] Cd Length: 363 Bit Score: 241.79 E-value: 1.53e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123158524 4 SLKPWNTFGIDHNAQHIVCAEDEQQLLNAWQHATAEGQPVLILGEGSNVLFLED-YRGTVIINRIKGIEIhdEPDAWYLH 82
Cdd:PRK13903 20 PLAPLTTLRVGGPARRLVTCTSTEELVAAVRELDAAGEPLLVLGGGSNLVIADDgFDGTVVRVATRGVTV--DCGGGLVR 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123158524 83 VGAGENWHRLVKYTLQEGMPGLENLALIPGCVGSSPIQNIGAYGVELQRVCAYVDCVELATGKQVRLTAKECRFGYRDSI 162
Cdd:PRK13903 98 AEAGAVWDDVVARTVEAGLGGLECLSGIPGSAGATPVQNVGAYGQEVSDTITRVRLLDRRTGEVRWVPAADLGFGYRTSV 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123158524 163 FKHEyqDRFAIVAVGLRLP--KEWQPVlTYGDLTR-LDPTT---VTPQQVFDAVCHMRTTK---L-PDPKVNGNAGSFFK 232
Cdd:PRK13903 178 LKHS--DRAVVLEVEFQLDpsGLSAPL-RYGELARaLGVEPgerVPPAAVREAVLALRAGKgmvLdPADHDTWSAGSFFT 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123158524 233 NPVVSAETAKALLAQ-----FPTAPNYPQTDGSVKLAAGWLIDQCQL-KGTQIGG--AAVHRQQALVLINEGNAKSEDIV 304
Cdd:PRK13903 255 NPVVSPAVAERLAARvaerlGDPVPRYPAGDGGVKLSAAWLIERAGFgKGYPGGGapARLSTKHTLALTNRGGATTADLV 334
|
330 340
....*....|....*....|....*...
gi 1123158524 305 QLAHHVRQKVGEKFNVWLEPEVRFIGTS 332
Cdd:PRK13903 335 ALAREVRDGVRDAFGVTLVPEPVLVGCS 362
|
|
| murB |
PRK13905 |
UDP-N-acetylmuramate dehydrogenase; |
2-330 |
3.07e-54 |
|
UDP-N-acetylmuramate dehydrogenase;
Pssm-ID: 237553 [Multi-domain] Cd Length: 298 Bit Score: 179.54 E-value: 3.07e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123158524 2 NHSLKPWNTFGIDHNAQHIVCAEDEQQLLNAWQHATAEGQPVLILGEGSNVLFLED-YRGTVIINR--IKGIEIHDEpda 78
Cdd:PRK13905 16 NEPLARYTSFRVGGPADYLVEPADIEDLQEFLKLLKENNIPVTVLGNGSNLLVRDGgIRGVVIRLGkgLNEIEVEGN--- 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123158524 79 wYLHVGAGENWHRLVKYTLQEGMPGLENLALIPGCVGSSPIQNIGAYGVELQRVcayVDCVELAT--GKQVRLTAKECRF 156
Cdd:PRK13905 93 -RITAGAGAPLIKLARFAAEAGLSGLEFAAGIPGTVGGAVFMNAGAYGGETADV---LESVEVLDrdGEIKTLSNEELGF 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123158524 157 GYRDSIFKHEyqdRFAIVAVGLRLPKEwqpvltygdltrlDPTTVtpQQVFDAVCHMRTTKLPdpkVNG-NAGSFFKNPv 235
Cdd:PRK13905 169 GYRHSALQEE---GLIVLSATFQLEPG-------------DKEEI--KARMDELLARREATQP---LEYpSAGSVFKNP- 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123158524 236 vsaetakallaqfptaPNYpqtdgsvklAAGWLIDQCQLKGTQIGGAAVHRQQALVLINEGNAKSEDIVQLAHHVRQKVG 315
Cdd:PRK13905 227 ----------------PGH---------FAGKLIEEAGLKGYRIGGAQVSEKHANFIINTGGATAADIEDLIEHVQKTVK 281
|
330
....*....|....*
gi 1123158524 316 EKFNVWLEPEVRFIG 330
Cdd:PRK13905 282 EKFGVELEWEVRIIG 296
|
|
| MurB_C |
pfam02873 |
UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Members of this family are ... |
206-329 |
5.67e-42 |
|
UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Members of this family are UDP-N-acetylenolpyruvoylglucosamine reductase enzymes EC:1.1.1.158. This enzyme is involved in the biosynthesis of peptidoglycan.
Pssm-ID: 460730 [Multi-domain] Cd Length: 99 Bit Score: 141.33 E-value: 5.67e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123158524 206 VFDAVCHMRTTKL-PDPKVNGNAGSFFKNPVvsaetakallaqfptapnypqtdgsvKLAAGWLIDQCQLKGTQIGGAAV 284
Cdd:pfam02873 1 IRAAMLELRRRRLaKQPLDPPSAGSFFKNPV--------------------------GHSAGWLIEQAGLKGYRIGGAQV 54
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 1123158524 285 HRQQALVLINEGNAKSEDIVQLAHHVRQKVGEKFNVWLEPEVRFI 329
Cdd:pfam02873 55 SEKHANFLVNTGGATAADVLALIEEVRERVKEKFGVELEPEVRII 99
|
|
| PRK14653 |
PRK14653 |
UDP-N-acetylmuramate dehydrogenase; |
39-326 |
1.36e-32 |
|
UDP-N-acetylmuramate dehydrogenase;
Pssm-ID: 237778 [Multi-domain] Cd Length: 297 Bit Score: 123.02 E-value: 1.36e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123158524 39 EGQPVLILGEGSNVLFLEDYRGTVII--NRIKGIEIHDEPdawyLHVGAGENWHRLVKYTLQEGMPGLENLALIPGCVGS 116
Cdd:PRK14653 55 EGIEVKILGNGTNVLPKDEPMDFVVVstERLDDIFVDNDK----IICESGLSLKKLCLVAAKNGLSGFENAYGIPGSVGG 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123158524 117 SPIQNIGAYGVELQRVCAYVDCVElatGKQV-RLTAKECRFGYRDSIFKHEyqDRFAIVAVGLRLPKEwQPVLTYGDLTR 195
Cdd:PRK14653 131 AVYMNAGAYGWETAENIVEVVAYD---GKKIiRLGKNEIKFSYRNSIFKEE--KDLIILRVTFKLKKG-NKNEIYNLMLE 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123158524 196 LDPTTVTPQQVfdavchmrttKLPdpkvngNAGSFFKNpvvsaetakallaqfptapnyPQTDGSVklaaGWLIDQCQLK 275
Cdd:PRK14653 205 TMKKRVEKQPL----------EFP------SAGSVFKR---------------------PRKDFYV----GSAIEKLGLK 243
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 1123158524 276 GTQIGGAAVHRQQALVLINEGNAKSEDIVQLAHHVRQKVGEKFNVWLEPEV 326
Cdd:PRK14653 244 GFSIGGAQISEKHAGFIINYNNAKAEDVLKLIEYVKDKIYENYNVELETEI 294
|
|
| PRK14649 |
PRK14649 |
UDP-N-acetylmuramate dehydrogenase; |
2-330 |
1.76e-29 |
|
UDP-N-acetylmuramate dehydrogenase;
Pssm-ID: 173112 [Multi-domain] Cd Length: 295 Bit Score: 114.55 E-value: 1.76e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123158524 2 NHSLKPWNTFGIDHNAQHIVCAEDEQQLLNAWQHATAEGQPVLILGEGSNVLFL-EDYRGTVIINRIKGIEIHDEPDAWY 80
Cdd:PRK14649 6 NEPLAPYTSWRIGGPARYFVEPTTPDEAIAAAAWAEQRQLPLFWLGGGSNLLVRdEGFDGLVARYRGQRWELHEHGDTAE 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123158524 81 LHVGAGENWHRLVKYTLQEGMPGLENLALIPGCVGSSPIQNIGAYGVELQRVCAYVDCveLATGKQ-VRLTAKECRFGYR 159
Cdd:PRK14649 86 VWVEAGAPMAGTARRLAAQGWAGLEWAEGLPGTIGGAIYGNAGCYGGDTATVLIRAWL--LLNGSEcVEWSVHDFAYGYR 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123158524 160 DSIFKHEYQDRfaivavglrlPKEWQPVLTYGDLT--RLDPTTVTpqQVFDAVCHMRTTKLPdpkVNGNAGSFFKNPvvs 237
Cdd:PRK14649 164 TSVLKQLRADG----------ITWRPPLVLAARFRlhRDDPTALA--ARMEAIAAERKQKTP---AGSSCGSVFKNP--- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123158524 238 aetakallaqfptapnyPQTdgsvklAAGWLIDQCQLKGTQIGGAAVHRQQALVLINEGNAKSEDIVQLAHHVRQKVGEK 317
Cdd:PRK14649 226 -----------------PGD------SAGRLIEAAGLKGTRIGDAEIATRHANYIINLGGARAADILRLIDLARTRVLAQ 282
|
330
....*....|...
gi 1123158524 318 FNVWLEPEVRFIG 330
Cdd:PRK14649 283 FGIELELEVRIIG 295
|
|
| FAD_binding_4 |
pfam01565 |
FAD binding domain; This family consists of various enzymes that use FAD as a co-factor, most ... |
17-150 |
2.18e-29 |
|
FAD binding domain; This family consists of various enzymes that use FAD as a co-factor, most of the enzymes are similar to oxygen oxidoreductase. One of the enzymes Vanillyl-alcohol oxidase (VAO) has a solved structure, the alignment includes the FAD binding site, called the PP-loop, between residues 99-110. The FAD molecule is covalently bound in the known structure, however the residue that links to the FAD is not in the alignment. VAO catalyzes the oxidation of a wide variety of substrates, ranging form aromatic amines to 4-alkylphenols. Other members of this family include D-lactate dehydrogenase, this enzyme catalyzes the conversion of D-lactate to pyruvate using FAD as a co-factor; mitomycin radical oxidase, this enzyme oxidizes the reduced form of mitomycins and is involved in mitomycin resistance. This family includes MurB an UDP-N-acetylenolpyruvoylglucosamine reductase enzyme EC:1.1.1.158. This enzyme is involved in the biosynthesis of peptidoglycan.
Pssm-ID: 426326 [Multi-domain] Cd Length: 139 Bit Score: 109.98 E-value: 2.18e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123158524 17 AQHIVCAEDEQQLLNAWQHATAEGQPVLILGEGSNVLFLEDYRGTVIIN--RIKGIEIHDePDAWYLHVGAGENWHRLVK 94
Cdd:pfam01565 1 PAAVVLPESEEEVAAIVRLANENGLPVLPRGGGSSLLGGAVQTGGIVLDlsRLNGILEID-PEDGTATVEAGVTLGDLVR 79
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1123158524 95 YTLQEG-MPGLENLALIPGCVGSSPIQNIGAYGVELQ----RVCAYVDCVeLATGKQVRLT 150
Cdd:pfam01565 80 ALAAKGlLLGLDPGSGIPGTVGGAIATNAGGYGSEKYgltrDNVLGLEVV-LADGEVVRLG 139
|
|
| murB |
PRK13906 |
UDP-N-acetylmuramate dehydrogenase; |
42-330 |
1.94e-21 |
|
UDP-N-acetylmuramate dehydrogenase;
Pssm-ID: 184386 [Multi-domain] Cd Length: 307 Bit Score: 92.96 E-value: 1.94e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123158524 42 PVLILGEGSNVLFLED-YRGTVI-INRIKGIEIHDEPdawyLHVGAGENWHRLVKYTLQEGMPGLENLALIPGCVGSSPI 119
Cdd:PRK13906 62 PVTYLGNGSNIIIREGgIRGIVIsLLSLDHIEVSDDA----IIAGSGAAIIDVSRVARDYALTGLEFACGIPGSIGGAVY 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123158524 120 QNIGAYGVELQRVCAYVDCVElATGKQVRLTAKECRFGYRDSIFKHEYqdrFAIVAVGLRLPKewqpvltyGDLTRLdpt 199
Cdd:PRK13906 138 MNAGAYGGEVKDCIDYALCVN-EQGSLIKLTTKELELDYRNSIIQKEH---LVVLEAAFTLAP--------GKMTEI--- 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123158524 200 tvtpQQVFDAVCHMRTTKlpDPKVNGNAGSFFKNPvvsaetakallaqfptaPNYpqtdgsvklAAGWLIDQCQLKGTQI 279
Cdd:PRK13906 203 ----QAKMDDLTERRESK--QPLEYPSCGSVFQRP-----------------PGH---------FAGKLIQDSNLQGHRI 250
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 1123158524 280 GGAAVHRQQALVLINEGNAKSEDIVQLAHHVRQKVGEKFNVWLEPEVRFIG 330
Cdd:PRK13906 251 GGVEVSTKHAGFMVNVDNGTATDYENLIHYVQKTVKEKFGIELNREVRIIG 301
|
|
| PRK12436 |
PRK12436 |
UDP-N-acetylmuramate dehydrogenase; |
34-330 |
9.02e-20 |
|
UDP-N-acetylmuramate dehydrogenase;
Pssm-ID: 171497 [Multi-domain] Cd Length: 305 Bit Score: 88.14 E-value: 9.02e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123158524 34 QHATAEGQPVLILGEGSNVLFLED-YRG-TVIINRIKGIEIHDEPdawyLHVGAGENWHRLVKYTLQEGMPGLENLALIP 111
Cdd:PRK12436 54 KYANKYNIPVTFLGNGSNVIIKDGgIRGiTVSLIHITGVTVTGTT----IVAQCGAAIIDVSRIALDHNLTGLEFACGIP 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123158524 112 GCVGSSPIQNIGAYGVELQRVCAYVdCVELATGKQVRLTAKECRFGYRDSIFKHEYqdrFAIVAVGLRLPKEwqpvlTYG 191
Cdd:PRK12436 130 GSVGGALYMNAGAYGGEISFVLTEA-VVMTGDGELRTLTKEAFEFGYRKSVFANNH---YIILEARFELEEG-----VYE 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123158524 192 DLtrldpttvtpQQVFDAVCHMRTTKlpDPKVNGNAGSFFKNPvvsaetakallaqfptaPNYpqtdgsvklAAGWLIDQ 271
Cdd:PRK12436 201 EI----------KAKMDDLTFKRESK--QPLEYPSCGSVFKRP-----------------PNN---------FAGKLIQE 242
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 1123158524 272 CQLKGTQIGGAAVHRQQALVLINEGNAKSEDIVQLAHHVRQKVGEKFNVWLEPEVRFIG 330
Cdd:PRK12436 243 SGLQGKRIGGVEVSLKHAGFMVNVDNGTAQDYIDLIHFVQKTVEEKFGVKLEREVRIIG 301
|
|
| PRK14651 |
PRK14651 |
UDP-N-acetylmuramate dehydrogenase; |
5-315 |
3.29e-16 |
|
UDP-N-acetylmuramate dehydrogenase;
Pssm-ID: 237776 [Multi-domain] Cd Length: 273 Bit Score: 77.55 E-value: 3.29e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123158524 5 LKPWNTFGIDHNAQhIVCAEDEQQLlnawqhATAEGQPVLILGEGSNVLFLEDYRGTVIInRIKGIEIHDEPDAWylhVG 84
Cdd:PRK14651 9 LARYTTLGVGGPAE-LWTVETHEQL------AEATEAPYRVLGGGSNLLVSDAGVPERVI-RLGGEFAEWDLDGW---VG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123158524 85 AGENWHRLVKYTLQEGMPGLENLALIPGCVGSSPIQNIGA-YGvelqRVCAYVDCVELAT-GKQVRLTAKECRFGYRDSi 162
Cdd:PRK14651 78 GGVPLPGLVRRAARLGLSGLEGLVGIPAQVGGAVKMNAGTrFG----EMADALHTVEIVHdGGFHQYSPDELGFGYRHS- 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123158524 163 fkheyqdrfaivavglRLPKewQPVLTYGDLtRLDPTtvTPQQVFDAVCHMRTTKLPDPKvNGNAGSFFKNPvvsaetak 242
Cdd:PRK14651 153 ----------------GLPP--GHVVTRVRL-KLRPS--TPEAVLAKMALVDAARKGQPK-KKSAGCAFKNP-------- 202
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1123158524 243 allaqfptapnypqtdGSVklAAGWLIDQCQLKGTQIGGAAVHRQQALVLINEGNAKSEDIVQLAHHVRQKVG 315
Cdd:PRK14651 203 ----------------PGD--SAGRLIDEAGLKGTRVGDAMISPEHGNFIVNLGGATAADVHALLRRVRARVG 257
|
|
| PRK14652 |
PRK14652 |
UDP-N-acetylmuramate dehydrogenase; |
39-330 |
1.12e-15 |
|
UDP-N-acetylmuramate dehydrogenase;
Pssm-ID: 237777 [Multi-domain] Cd Length: 302 Bit Score: 76.45 E-value: 1.12e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123158524 39 EGQPVLILGEGSNVLFLE-DYRGTVIinRIKGIEIHDEPDAWYLHVGAGENWHRLVKYTLQEGMPGLENLALIPGCVGSS 117
Cdd:PRK14652 58 LGVPLSILGGGANTLVADaGVRGVVL--RLPQDFPGESTDGGRLVLGAGAPISRLPARAHAHGLVGMEFLAGIPGTLGGA 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123158524 118 PIQNIGAYGVELQRVcayVDCVELATGKQVR-LTAKECRFGYRDSifkheyqdrfaivavglRLPKewQPVLTYGDLTRL 196
Cdd:PRK14652 136 VAMNAGTKLGEMKDV---VTAVELATADGAGfVPAAALGYAYRTC-----------------RLPP--GAVITRVEVRLR 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123158524 197 DPTTVTPQQVFDAVCHMR--TTKLPDPkvngNAGSFFKNPvvsaetakallaqfptapnyPQTdgsvklAAGWLIDQCQL 274
Cdd:PRK14652 194 PGDVAASEALMRADRERRrrTQPLDRP----TFGSTFTNP--------------------PGD------YAGRLVEAVGL 243
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 1123158524 275 KGTQIGGAAVHRQQALVLINEGNAKSEDIVQLAHHVRQKVGEKFNVWLEPEVRFIG 330
Cdd:PRK14652 244 KGHRVGGAIWSPVHANFVTNLGGATARDVLALVRLARARVKERFGIALETEVRLLG 299
|
|
| murB |
PRK13904 |
UDP-N-acetylmuramate dehydrogenase; |
70-326 |
2.09e-14 |
|
UDP-N-acetylmuramate dehydrogenase;
Pssm-ID: 184384 [Multi-domain] Cd Length: 257 Bit Score: 71.88 E-value: 2.09e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123158524 70 IEIHDEpdawYLHVGAGENWHRLVKYTLQEGMPGLENLALIPGCVGSSPIQNIGAYGVELQRvcaYVDCVELATGKqvrL 149
Cdd:PRK13904 62 IKIDGE----CLEIGGATKSGKIFNYAKKNNLGGFEFLGKLPGTLGGLVKMNAGLKEYEISN---NLESICTNGGW---I 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123158524 150 TAKECRFGYRDSIFKHeyqdrfaiVAVGLRLPKEwqpvltYGDLTRLDpttvtpqqvfDAVCHMRTT--KLPdpkvngNA 227
Cdd:PRK13904 132 EKEDIGFGYRSSGING--------VILEARFKKT------HGFDEELL----------EAFKSMRKNqpKGP------SF 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123158524 228 GSFFKNPvvsaetakallaqfptaPN-YpqtdgsvklaAGWLIDQCQLKGTQIGGAAVHRQQALVLINEGNAKSEDIVQL 306
Cdd:PRK13904 182 GSCFKNP-----------------KGdY----------AGRLIEAVGLKGYCKGGAGFSEEHANFLVNLGGATFEDALDL 234
|
250 260
....*....|....*....|
gi 1123158524 307 AHHVRQKVGEKFNVWLEPEV 326
Cdd:PRK13904 235 IELAKKRVLEEFGINLEEEV 254
|
|
| PRK14650 |
PRK14650 |
UDP-N-acetylmuramate dehydrogenase; |
31-330 |
1.08e-13 |
|
UDP-N-acetylmuramate dehydrogenase;
Pssm-ID: 173113 [Multi-domain] Cd Length: 302 Bit Score: 70.64 E-value: 1.08e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123158524 31 NAWQHATAEGQPVLILGEGSNVLFLEDYR---GTVIINRIKGIEIHDEPdawyLHVGAGENWHRLVKYTLQEGMPGLENL 107
Cdd:PRK14650 47 HIFKAAIEEKIKIFILGGGSNILINDEEEidfPIIYTGHLNKIEIHDNQ----IVAECGTNFEDLCKFALQNELSGLEFI 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123158524 108 ALIPGCVGSSPIQNIGAYGVELQRVCAYVDCVElATGKQVRLTAKECRFGYRDSIFKHEyqdRFAIVAVGLRLPKEWQPV 187
Cdd:PRK14650 123 YGLPGTLGGAIWMNARCFGNEISEILDKITFID-EKGKTICKKFKKEEFKYKISPFQNK---NTFILKATLNLKKGNKKH 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123158524 188 LtygdltrldpttvtpQQVFDAVCHMRTTK----LPdpkvngNAGSFFKNpvvsaetAKALLAqfPTapnypqtdgsvkl 263
Cdd:PRK14650 199 I---------------EEIMKQNKQIRINKghylFP------SSGSTFKN-------NKAFLK--PT------------- 235
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1123158524 264 aaGWLIDQCQLKGTQIGGAAVHRQQALVLINEGNAKSEDIVQLAHHVRQKVGEKFNVWLEPEVRFIG 330
Cdd:PRK14650 236 --GQIIEECKLKGLSIGGATVSHYHGNFIININNATSKDIKTLIEKVKTEVQIKTGFLLEEEVLYIG 300
|
|
| PRK14648 |
PRK14648 |
UDP-N-acetylmuramate dehydrogenase; |
42-332 |
9.29e-12 |
|
UDP-N-acetylmuramate dehydrogenase;
Pssm-ID: 173111 [Multi-domain] Cd Length: 354 Bit Score: 65.13 E-value: 9.29e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123158524 42 PVLILGEGSNVLFLEDYRGTVIIN--RIKGIEIHDEPDAWYL-HVGAGENWHRLVKYTLQEGMPGLENLALIPGCVGSSP 118
Cdd:PRK14648 55 PLSLIGGGSNVLIADEGVPGLMLSlrRFRSLHTQTQRDGSVLvHAGAGLPVAALLAFCAHHALRGLETFAGLPGSVGGAA 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123158524 119 IQNIGAYGVelqrvcAYVDCVELATG---KQVRLTAKECrfgyrDSIFKHEYQDRFAIVAV--GLRLPKEWQPVLTY-GD 192
Cdd:PRK14648 135 YMNARCYGR------AIADCFHSARTlvlHPVRSRAKEL-----PEVRKNAQDKRGECLGLdgGPFTCSSFQTVFARaGD 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123158524 193 LTRLDPTTVTPQQVFDAVCHMRTTKLPDPKVNGNAGSFFKN--PVVSAETAKALLaQFPTAPNYPQTDGSVKLAAGWLID 270
Cdd:PRK14648 204 WGYKRSPFQSPHGVELHAGRRLILSLCVRLTPGNPAQIRKHmqEKIADRISKGQF-RFPSAGSAFKNNPAFGKPSGILIE 282
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1123158524 271 QCQLKGTQIGGAAVHRQQALVLINEGNAKSEDIVQLAHHVRQKVGEKFNVWLEPEVRFIGTS 332
Cdd:PRK14648 283 EAGLRGTSCGAAQVAPWHGNLIINTGNATAHQVRTLLRVVRQRVFETHGVWLEREIIFSGES 344
|
|
| |
