capsular biosynthesis protein [Campylobacter jejuni]
Protein Classification
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||||
| TagB | COG1887 | CDP-glycerol glycerophosphotransferase, TagB/SpsB family [Cell wall/membrane/envelope ... |
471-815 | 1.99e-48 | ||||||
CDP-glycerol glycerophosphotransferase, TagB/SpsB family [Cell wall/membrane/envelope biogenesis, Lipid transport and metabolism]; : Pssm-ID: 441491 Cd Length: 369 Bit Score: 175.95 E-value: 1.99e-48
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| Glyco_tranf_GTA_type | cd00761 | Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ... |
41-197 | 3.91e-24 | ||||||
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities. : Pssm-ID: 132997 [Multi-domain] Cd Length: 156 Bit Score: 99.50 E-value: 3.91e-24
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| Name | Accession | Description | Interval | E-value | ||||||
| TagB | COG1887 | CDP-glycerol glycerophosphotransferase, TagB/SpsB family [Cell wall/membrane/envelope ... |
471-815 | 1.99e-48 | ||||||
CDP-glycerol glycerophosphotransferase, TagB/SpsB family [Cell wall/membrane/envelope biogenesis, Lipid transport and metabolism]; Pssm-ID: 441491 Cd Length: 369 Bit Score: 175.95 E-value: 1.99e-48
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| Glyphos_transf | pfam04464 | CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Wall-associated teichoic acids ... |
484-808 | 1.07e-33 | ||||||
CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Wall-associated teichoic acids are a heterogeneous class of phosphate-rich polymers that are covalently linked to the cell wall peptidoglycan of gram-positive bacteria. They consist of a main chain of phosphodiester-linked polyols and/or sugar moieties attached to peptidoglycan via a linkage unit. CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase is responsible for the polymerization of the main chain of the teichoic acid by sequential transfer of glycerol-phosphate units from CDP-glycerol to the linkage unit lipid. Pssm-ID: 398259 Cd Length: 360 Bit Score: 133.24 E-value: 1.07e-33
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| Glyco_tranf_GTA_type | cd00761 | Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ... |
41-197 | 3.91e-24 | ||||||
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities. Pssm-ID: 132997 [Multi-domain] Cd Length: 156 Bit Score: 99.50 E-value: 3.91e-24
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| WcaA | COG0463 | Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ... |
39-183 | 1.75e-20 | ||||||
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; Pssm-ID: 440231 [Multi-domain] Cd Length: 208 Bit Score: 90.53 E-value: 1.75e-20
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| Glycos_transf_2 | pfam00535 | Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ... |
42-187 | 2.67e-20 | ||||||
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids. Pssm-ID: 425738 [Multi-domain] Cd Length: 166 Bit Score: 88.61 E-value: 2.67e-20
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| PRK10073 | PRK10073 | putative glycosyl transferase; Provisional |
38-177 | 2.30e-19 | ||||||
putative glycosyl transferase; Provisional Pssm-ID: 182223 [Multi-domain] Cd Length: 328 Bit Score: 90.11 E-value: 2.30e-19
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| surf_polysacc | TIGR04396 | surface carbohydrate biosynthesis protein; This model describes an uncharacterized homology ... |
532-779 | 4.58e-05 | ||||||
surface carbohydrate biosynthesis protein; This model describes an uncharacterized homology region found broadly in proteins of surface carbohydrate biosynthesis regions. This family shows distant homology to regions of family TIGR04326, of spore coat polysaccharide biosynthesis protein SpsB from Bacillus subtilis, etc. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides] Pssm-ID: 275189 Cd Length: 321 Bit Score: 46.50 E-value: 4.58e-05
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| GTB_UDP-GlcNAc_2-Epimerase | cd03786 | UDP-N-acetylglucosamine 2-epimerase and similar proteins; Bacterial members of the ... |
626-766 | 2.68e-04 | ||||||
UDP-N-acetylglucosamine 2-epimerase and similar proteins; Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family (EC 5.1.3.14) are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues (UDP-ManNAc) for use in the biosynthesis of a variety of cell surface polysaccharides; The mammalian enzyme is bifunctional, catalyzing both the inversion of stereochemistry at C-2 and the hydrolysis of the UDP-sugar linkage to generate free ManNAc. It also catalyzes the phosphorylation of ManNAc to generate ManNAc 6-phosphate, a precursor to salic acids. In mammals, sialic acids are found at the termini of oligosaccharides in a large variety of cell surface glycoconjugates and are key mediators of cell-cell recognition events. Mutations in human members of this family have been associated with Sialuria, a rare disease caused by the disorders of sialic acid metabolism. This family belongs to the GT-B structural superfamily of glycoslytransferases, which have characteristic N- and C-terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. Pssm-ID: 340819 [Multi-domain] Cd Length: 365 Bit Score: 44.12 E-value: 2.68e-04
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| Name | Accession | Description | Interval | E-value | ||||||
| TagB | COG1887 | CDP-glycerol glycerophosphotransferase, TagB/SpsB family [Cell wall/membrane/envelope ... |
471-815 | 1.99e-48 | ||||||
CDP-glycerol glycerophosphotransferase, TagB/SpsB family [Cell wall/membrane/envelope biogenesis, Lipid transport and metabolism]; Pssm-ID: 441491 Cd Length: 369 Bit Score: 175.95 E-value: 1.99e-48
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| Glyphos_transf | pfam04464 | CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Wall-associated teichoic acids ... |
484-808 | 1.07e-33 | ||||||
CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Wall-associated teichoic acids are a heterogeneous class of phosphate-rich polymers that are covalently linked to the cell wall peptidoglycan of gram-positive bacteria. They consist of a main chain of phosphodiester-linked polyols and/or sugar moieties attached to peptidoglycan via a linkage unit. CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase is responsible for the polymerization of the main chain of the teichoic acid by sequential transfer of glycerol-phosphate units from CDP-glycerol to the linkage unit lipid. Pssm-ID: 398259 Cd Length: 360 Bit Score: 133.24 E-value: 1.07e-33
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| Glyco_tranf_GTA_type | cd00761 | Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ... |
41-197 | 3.91e-24 | ||||||
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities. Pssm-ID: 132997 [Multi-domain] Cd Length: 156 Bit Score: 99.50 E-value: 3.91e-24
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| WcaA | COG0463 | Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ... |
39-183 | 1.75e-20 | ||||||
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; Pssm-ID: 440231 [Multi-domain] Cd Length: 208 Bit Score: 90.53 E-value: 1.75e-20
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| Glycos_transf_2 | pfam00535 | Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ... |
42-187 | 2.67e-20 | ||||||
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids. Pssm-ID: 425738 [Multi-domain] Cd Length: 166 Bit Score: 88.61 E-value: 2.67e-20
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| PRK10073 | PRK10073 | putative glycosyl transferase; Provisional |
38-177 | 2.30e-19 | ||||||
putative glycosyl transferase; Provisional Pssm-ID: 182223 [Multi-domain] Cd Length: 328 Bit Score: 90.11 E-value: 2.30e-19
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| BcsA | COG1215 | Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ... |
29-169 | 1.51e-17 | ||||||
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility]; Pssm-ID: 440828 [Multi-domain] Cd Length: 303 Bit Score: 84.41 E-value: 1.51e-17
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| Succinoglycan_BP_ExoA | cd02525 | ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA ... |
42-276 | 3.33e-14 | ||||||
ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA catalyzes the formation of a beta-1,3 linkage of the second sugar (glucose) of the succinoglycan with the galactose on the lipid carrie. Succinoglycan is an acidic exopolysaccharide that is important for invasion of the nodules. Succinoglycan is a high-molecular-weight polymer composed of repeating octasaccharide units. These units are synthesized on membrane-bound isoprenoid lipid carriers, beginning with galactose followed by seven glucose molecules, and modified by the addition of acetate, succinate, and pyruvate. ExoA is a membrane protein with a transmembrance domain at c-terminus. Pssm-ID: 133016 [Multi-domain] Cd Length: 249 Bit Score: 73.03 E-value: 3.33e-14
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| GT_2_like_d | cd04196 | Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ... |
42-137 | 4.78e-13 | ||||||
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families. Pssm-ID: 133039 [Multi-domain] Cd Length: 214 Bit Score: 69.20 E-value: 4.78e-13
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| WcaE | COG1216 | Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism]; |
41-144 | 2.15e-12 | ||||||
Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism]; Pssm-ID: 440829 [Multi-domain] Cd Length: 202 Bit Score: 66.94 E-value: 2.15e-12
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| CESA_like | cd06423 | CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily ... |
41-176 | 1.81e-11 | ||||||
CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins. Cellulose synthase catalyzes the polymerization reaction of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues in plants, most algae, some bacteria and fungi, and even some animals. In bacteria, algae and lower eukaryotes, there is a second unrelated type of cellulose synthase (Type II), which produces acylated cellulose, a derivative of cellulose. Chitin synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin, which is a linear homopolymer of beta-(1,4)-linked GlcNAc residues and Glucan Biosynthesis protein catalyzes the elongation of beta-1,2 polyglucose chains of Glucan. Pssm-ID: 133045 [Multi-domain] Cd Length: 180 Bit Score: 63.79 E-value: 1.81e-11
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| DPM_DPG-synthase_like | cd04179 | DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the ... |
42-136 | 9.54e-11 | ||||||
DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. The UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate. This protein family belongs to Glycosyltransferase 2 superfamily. Pssm-ID: 133022 [Multi-domain] Cd Length: 185 Bit Score: 61.82 E-value: 9.54e-11
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| GT2_RfbC_Mx_like | cd04184 | Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; The rfbC gene ... |
42-160 | 5.23e-10 | ||||||
Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; The rfbC gene encodes a predicted protein of 1,276 amino acids, which is required for O-antigen biosynthesis in Myxococcus xanthus. It is a subfamily of Glycosyltransferase Family GT2, which includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Pssm-ID: 133027 [Multi-domain] Cd Length: 202 Bit Score: 59.91 E-value: 5.23e-10
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| GT_2_like_c | cd04186 | Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ... |
42-161 | 6.86e-10 | ||||||
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families. Pssm-ID: 133029 [Multi-domain] Cd Length: 166 Bit Score: 58.72 E-value: 6.86e-10
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| GT_2_WfgS_like | cd06433 | WfgS and WfeV are involved in O-antigen biosynthesis; Escherichia coli WfgS and Shigella ... |
42-224 | 7.64e-10 | ||||||
WfgS and WfeV are involved in O-antigen biosynthesis; Escherichia coli WfgS and Shigella dysenteriae WfeV are glycosyltransferase 2 family enzymes involved in O-antigen biosynthesis. GT-2 enzymes have GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families. Pssm-ID: 133055 [Multi-domain] Cd Length: 202 Bit Score: 59.48 E-value: 7.64e-10
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| CESA_like_1 | cd06439 | CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of ... |
18-142 | 3.58e-08 | ||||||
CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of cellulose synthase (CESA) superfamily. CESA superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members of the superfamily include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins. Pssm-ID: 133061 [Multi-domain] Cd Length: 251 Bit Score: 55.28 E-value: 3.58e-08
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| DPM1_like_bac | cd04187 | Bacterial DPM1_like enzymes are related to eukaryotic DPM1; A family of bacterial enzymes ... |
42-97 | 9.84e-08 | ||||||
Bacterial DPM1_like enzymes are related to eukaryotic DPM1; A family of bacterial enzymes related to eukaryotic DPM1; Although the mechanism of eukaryotic enzyme is well studied, the mechanism of the bacterial enzymes is not well understood. The eukaryotic DPM1 is the catalytic subunit of eukaryotic Dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. The enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. This protein family belongs to Glycosyltransferase 2 superfamily. Pssm-ID: 133030 [Multi-domain] Cd Length: 181 Bit Score: 52.86 E-value: 9.84e-08
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| DPG_synthase | cd04188 | DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate ... |
41-136 | 1.68e-07 | ||||||
DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate. Pssm-ID: 133031 [Multi-domain] Cd Length: 211 Bit Score: 52.57 E-value: 1.68e-07
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| beta3GnTL1_like | cd06913 | Beta 1, 3-N-acetylglucosaminyltransferase is essential for the formation of ... |
42-116 | 4.66e-07 | ||||||
Beta 1, 3-N-acetylglucosaminyltransferase is essential for the formation of poly-N-acetyllactosamine ; This family includes human Beta3GnTL1 and related eukaryotic proteins. Human Beta3GnTL1 is a putative beta-1,3-N-acetylglucosaminyltransferase. Beta3GnTL1 is expressed at various levels in most of tissues examined. Beta 1, 3-N-acetylglucosaminyltransferase has been found to be essential for the formation of poly-N-acetyllactosamine. Poly-N-acetyllactosamine is a unique carbohydrate composed of N-acetyllactosamine repeats. It is often an important part of cell-type-specific oligosaccharide structures and some functional oligosaccharides. It has been shown that the structure and biosynthesis of poly-N-acetyllactosamine display a dramatic change during development and oncogenesis. Several members of beta-1, 3-N-acetylglucosaminyltransferase have been identified. Pssm-ID: 133063 [Multi-domain] Cd Length: 219 Bit Score: 51.30 E-value: 4.66e-07
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| GT2_Chondriotin_Pol_N | cd06420 | N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Chondroitin ... |
41-143 | 2.55e-05 | ||||||
N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Chondroitin polymerase is a two domain, bi-functional protein. The N-terminal domain functions as a GalNAc transferase. The bacterial chondroitin polymerase catalyzes elongation of the chondroitin chain by alternatively transferring the GlcUA and GalNAc moiety from UDP-GlcUA and UDP-GalNAc to the non-reducing ends of the chondroitin chain. The enzyme consists of N-terminal and C-terminal domains in which the two active sites catalyze the addition of GalNAc and GlcUA, respectively. Chondroitin chains range from 40 to over 100 repeating units of the disaccharide. Sulfated chondroitins are involved in the regulation of various biological functions such as central nervous system development, wound repair, infection, growth factor signaling, and morphogenesis, in addition to its conventional structural roles. In Caenorhabditis elegans, chondroitin is an essential factor for the worm to undergo cytokinesis and cell division. Chondroitin is synthesized as proteoglycans, sulfated and secreted to the cell surface or extracellular matrix. Pssm-ID: 133042 [Multi-domain] Cd Length: 182 Bit Score: 45.65 E-value: 2.55e-05
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| surf_polysacc | TIGR04396 | surface carbohydrate biosynthesis protein; This model describes an uncharacterized homology ... |
532-779 | 4.58e-05 | ||||||
surface carbohydrate biosynthesis protein; This model describes an uncharacterized homology region found broadly in proteins of surface carbohydrate biosynthesis regions. This family shows distant homology to regions of family TIGR04326, of spore coat polysaccharide biosynthesis protein SpsB from Bacillus subtilis, etc. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides] Pssm-ID: 275189 Cd Length: 321 Bit Score: 46.50 E-value: 4.58e-05
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| GT2_AmsE_like | cd04195 | GT2_AmsE_like is involved in exopolysaccharide amylovora biosynthesis; AmsE is a ... |
45-153 | 2.67e-04 | ||||||
GT2_AmsE_like is involved in exopolysaccharide amylovora biosynthesis; AmsE is a glycosyltransferase involved in exopolysaccharide amylovora biosynthesis in Erwinia amylovora. Amylovara is one of the three exopolysaccharide produced by E. amylovora. Amylovara-deficient mutants are non-pathogenic. It is a subfamily of Glycosyltransferase Family GT2, which includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Pssm-ID: 133038 [Multi-domain] Cd Length: 201 Bit Score: 43.07 E-value: 2.67e-04
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| GTB_UDP-GlcNAc_2-Epimerase | cd03786 | UDP-N-acetylglucosamine 2-epimerase and similar proteins; Bacterial members of the ... |
626-766 | 2.68e-04 | ||||||
UDP-N-acetylglucosamine 2-epimerase and similar proteins; Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family (EC 5.1.3.14) are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues (UDP-ManNAc) for use in the biosynthesis of a variety of cell surface polysaccharides; The mammalian enzyme is bifunctional, catalyzing both the inversion of stereochemistry at C-2 and the hydrolysis of the UDP-sugar linkage to generate free ManNAc. It also catalyzes the phosphorylation of ManNAc to generate ManNAc 6-phosphate, a precursor to salic acids. In mammals, sialic acids are found at the termini of oligosaccharides in a large variety of cell surface glycoconjugates and are key mediators of cell-cell recognition events. Mutations in human members of this family have been associated with Sialuria, a rare disease caused by the disorders of sialic acid metabolism. This family belongs to the GT-B structural superfamily of glycoslytransferases, which have characteristic N- and C-terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. Pssm-ID: 340819 [Multi-domain] Cd Length: 365 Bit Score: 44.12 E-value: 2.68e-04
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| WecB | COG0381 | UDP-N-acetylglucosamine 2-epimerase [Cell wall/membrane/envelope biogenesis]; |
696-766 | 6.22e-04 | ||||||
UDP-N-acetylglucosamine 2-epimerase [Cell wall/membrane/envelope biogenesis]; Pssm-ID: 440150 Cd Length: 366 Bit Score: 43.13 E-value: 6.22e-04
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| Beta4Glucosyltransferase | cd02511 | UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of ... |
74-286 | 9.66e-04 | ||||||
UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; UDP-glucose: lipooligosaccharide (LOS) beta-1-4-glucosyltransferase catalyzes the addition of the first residue, glucose, of the lacto-N-neotetrase structure to HepI of the LOS inner core. LOS is the major constituent of the outer leaflet of the outer membrane of gram-positive bacteria. It consists of a short oligosaccharide chain of variable composition (alpha chain) attached to a branched inner core which is lined in turn to lipid A. Beta 1,4 glucosyltransferase is required to attach the alpha chain to the inner core. Pssm-ID: 133005 [Multi-domain] Cd Length: 229 Bit Score: 41.51 E-value: 9.66e-04
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| GT_2_like_e | cd04192 | Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ... |
42-173 | 1.22e-03 | ||||||
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families. Pssm-ID: 133035 [Multi-domain] Cd Length: 229 Bit Score: 41.12 E-value: 1.22e-03
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| Epimerase_2 | pfam02350 | UDP-N-acetylglucosamine 2-epimerase; This family consists of UDP-N-acetylglucosamine ... |
696-766 | 5.06e-03 | ||||||
UDP-N-acetylglucosamine 2-epimerase; This family consists of UDP-N-acetylglucosamine 2-epimerases EC:5.1.3.14 this enzyme catalyzes the production of UDP-ManNAc from UDP-GlcNAc. Note that some of the enzymes is this family are bifunctional such as Swiss:O35826 and Swiss:Q9Z0P6 in this instance Pfam matches only the N-terminal half of the protein suggesting that the additional C-terminal part (when compared to mono-functional members of this family) is responsible for the UPD-N-acetylmannosamine kinase activity of these enzymes. This hypothesis is further supported by the assumption that the C-terminal part of Swiss:O35826 is the kinase domain. Pssm-ID: 426733 [Multi-domain] Cd Length: 336 Bit Score: 39.83 E-value: 5.06e-03
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