|
Name |
Accession |
Description |
Interval |
E-value |
| YdfJ |
COG2409 |
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ... |
35-714 |
4.39e-172 |
|
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];
Pssm-ID: 441964 [Multi-domain] Cd Length: 697 Bit Score: 509.69 E-value: 4.39e-172
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 35 FFFPKAADYKDDAAKDLPNSEpSVVAQKLIDDKFAGTDGVPALITWYRSTG-LTTEDLVN-IQKYSKELTENPvDYQKMA 112
Cdd:COG2409 21 VLAPQLGGSLSSNGFFLPGSE-SQRAADLLAEAFPESDGASAVVVVEAPDGtLTDPAFRAaVAALVARLRADP-GVAGVQ 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 113 VPYDKMPPvalkQQVSKDGTTFIQTVIMKDSATsDQLTESFKQLESAAKTTigenpfaqkvsADDALVARTTGPAGISVD 192
Cdd:COG2409 99 DPWDDPAA----GLVSEDGKAALVTVTLDGDAG-DEAAEAVDALRDAVAAA-----------PAPGLTVYVTGPAALAAD 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 193 ASGLFKDADVSLLIGTVLLVLVFLLVIYRSPILALIPLIAVGFAYLVITPILGLLAKegIITYGSQGLSIMTVLLFGAGT 272
Cdd:COG2409 163 LNEAFEEDLGRAELITLPVALVVLLLVFRSLVAALLPLLTAGLAVGVALGLLALLAA--FTDVSSFAPNLLTMLGLGVGI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 273 DYCLFLISRFRSHLHTEKNRFQAFKEAFSGTAGAIALSGLTVMAALLLLLAAEYGSFHNFAVPFSLAIFIMMISSLTLVP 352
Cdd:COG2409 241 DYALFLVSRYREELRAGEDREEAVARAVATAGRAVLFSGLTVAIALLGLLLAGLPFLRSMGPAAAIGVAVAVLAALTLLP 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 353 ALLGIFGRVSFWPFVPRTLEMEETRakkkgktpkhhkeNRFWHKIGEMSAKHPVRILIITLIILIGCGIFTTQVKYTYDT 432
Cdd:COG2409 321 ALLALLGRRVFWPRRPRRRRAAAPE-------------SGFWRRLARAVVRRPVPVLVAAVAVLLALALPALGLRLGLPD 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 433 LSTFPEDMPSREGFTLISDHFGAGMLAPMEVVVNSKESM-----------KSSLENVDGVASVTGPERSKG----YQKYT 497
Cdd:COG2409 388 ADSLPADSPSRQGYDALAEHFPPGSNGPLTVVVESDDDLdpadlaaldalAAALAAVPGVASVQPPTRPEGtdgdAARLQ 467
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 498 LILKDNPYSNEAMDVVPKVRAAAD---KGNDVYIAGQTATQYDDRAVTEHDEKVIIPLVIALIAILLLCYLRSITAMLYL 574
Cdd:COG2409 468 VVPDGDPDSPEAIDLVDRLRDAAApalEGAEVLVGGTTAVNIDISDALADDLPLVIPVVLGLIFLLLLLLFRSVVAPLKA 547
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 575 VATVLLSFVGALGLGWVIIHYAMGV-----EAISGLIPLYAFVFIVALGEDYNIFMISSIWKNS-KKMPLRKAITEGVGQ 648
Cdd:COG2409 548 VLTNLLSLGAALGVLVLVFQHGWLLlgftpGPLDSFVPLLLFVILFGLGMDYEVFLVSRIREEYdRGGGTREAVIRGLAR 627
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1072179535 649 TGGVITSAGLILAGTFGVLTTLPIQLLVQFGLITAIGVLLDTFIVRPFLVPSITVLLGKWAFW-PGK 714
Cdd:COG2409 628 TGRVITSAALIMAAVFAAFATSPLVFLKQIGFGLAVGVLLDAFVVRMLLVPALMALLGRWNWWlPRW 694
|
|
| actII |
TIGR00833 |
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family ... |
33-492 |
1.97e-44 |
|
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family (TC 2.A.6.5)Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. This sub-family includes the S. coelicolor ActII3 protein, which may play a role in drug resistance, and the M. tuberculosis MmpL7 protein, which catalyzes export of an outer membrane lipid, phthiocerol dimycocerosate. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 129913 [Multi-domain] Cd Length: 910 Bit Score: 171.69 E-value: 1.97e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 33 LQFFFPKAAD--YKDDAAKdLPNSEPSVVAQKLIDDKFAGTDGVPALITW-YRSTGLTTEDLVNIQKYSKELTENPVDYQ 109
Cdd:TIGR00833 17 LQLLAPLLEDvsYFRLQAE-LPGGAASSIAVKEMSAAFQEAIRDPKIILVlESNERLGDKDYATYDALIAKLRADIMHVI 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 110 K----MAVPYdkMPPVAlkqqVSKDGTTFIQTVIMKDSATSDQLTESFKQLESAAKTTigenpfaqkvSADDALVARTTG 185
Cdd:TIGR00833 96 SvvdfWGPPE--AAEGL----RSDDGKATIIIVNLAGEKGQKEAQEAINAVRRIVEQT----------NAPDGLTVHVTG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 186 PAGISVDASGLFKDADVSLLIGTVLLVLVFLLVIYRSPILALIPLIAVGFAYLVITPILGLLAKEGIITYGSQGLSIMTV 265
Cdd:TIGR00833 160 PLATIADILESGDKDMNRITATTGIIVLIILLLVYRSPITMLVPLVSVGFSVVVAQGIVSLLGIPGLIGVNAQTTVLLTA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 266 LLFGAGTDYCLFLISRFRSHLHTEKNRFQAFKEAFSGTAGAIALSGLTVMAALLLLLAAEYGSFHNFAVPFSLAIFIMMI 345
Cdd:TIGR00833 240 LVIGAGTDYAVFLTGRYHEERRKGESLEEAAAEALRGTGKAILGSALTVAVAFLALSLARLPSFKTLGVSCAVGVLVALL 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 346 SSLTLVPALLGIFGRVSFWpfvprtlemeetrakkkgKTPKHHKENRFWHKIGEMSAKHPVRILIITLIILIGCGIFTTQ 425
Cdd:TIGR00833 320 NAVTLTPALLTLEGREGLM------------------KPGRKSKIRFIWRRLGTAVVRRPWPILVTTLIISGVSLLALPL 381
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1072179535 426 VKYTYDTLSTFPEDMPSREGFTLISDHFGAGMLAPMEVVVNSK------------ESMKSSLENVDGVASVTGPERSKG 492
Cdd:TIGR00833 382 IRTGYDDEKMIPTDLESVQGYEAADRHFPGNSMDPMVVMIKSDhdvrnpalladiDRFEREIKAVPGINMVQETQRPDG 460
|
|
| MMPL |
pfam03176 |
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ... |
51-406 |
3.08e-44 |
|
MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.
Pssm-ID: 308676 [Multi-domain] Cd Length: 332 Bit Score: 162.08 E-value: 3.08e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 51 LPNSEPSVVAQKLIDDKFAGTDGVPALITWYRSTGLTTEDLVNIQKYSKELTENPVDYQKMAVPYDKMP-PVALKQQVSK 129
Cdd:pfam03176 3 SPADAPSVRAMDRLGAAFPQADSDPIIVVVLGEGDQALGDAAAEAGYDTLVDALRADTGHVGSVQDFWGdPDTAALFVSP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 130 DGTTFIQTVIMKDSATSDQLTESFKQLESAAKTTIgenpfaqkvsADDALVARTTGPAGISVDASGLFKDADVSLLIGTV 209
Cdd:pfam03176 83 DGKAAYVVVTLEGDPGTTEADESVAAVRDAVEQAP----------PPEGLKAYLTGPAATVADLRDAGDRDLGLIEAVTL 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 210 LLVLVFLLVIYRSPILALIPLIAVGFAYLVITPILGLLAKEGIITYGSQGLSIMTVLLFGAGTDYCLFLISRFRSHLHTE 289
Cdd:pfam03176 153 VVIFIILLIVYRSVVAALLPLLTVGLSLGAAQGLVAILAHILGIGLSTFALNLLVVLLIAVGTDYALFLVSRYREELRAG 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 290 KNRFQAFKEAFSGTAGAIALSGLTVMAALLLLLAAEYGSFHNFAVPFSLAIFIMMISSLTLVPALLGIFGRVSFWPfvpr 369
Cdd:pfam03176 233 EDREEAVIRAVRGTGKVVTAAGLTVAIAMLALSFARLPVFAQVGPTIAIGVLVDVLAALTLLPALLALLGRWGLWP---- 308
|
330 340 350
....*....|....*....|....*....|....*..
gi 1072179535 370 tlemeetrakkkgktPKHHKENRFWHKIGEMSAKHPV 406
Cdd:pfam03176 309 ---------------PKRDRTARWWRRIGRLVVRRPA 330
|
|
| RND_permease_2 |
NF033617 |
multidrug efflux RND transporter permease subunit; |
546-692 |
3.93e-03 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 411236 [Multi-domain] Cd Length: 1009 Bit Score: 40.77 E-value: 3.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 546 EKVIIPLVIALIAILLLCYL--RSITAMLYLVATVLLSFVGALGLgwviiHYAMGVEAisGLIPLYAFVFIVALGEDYNI 623
Cdd:NF033617 330 DEVESTLLEAVALVILVVFLflRNLRATLIPAVTVPLSLIGTFAV-----MYLFGFSI--NLLTLMALVLAIGLVVDDAI 402
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1072179535 624 FMISSIWKNSK--KMPLRKAItEGVGQTGGVITSAGLILAGTF---GVLTTLPIQLLVQFGLITAIGVLLDTFI 692
Cdd:NF033617 403 VVVENIHRHIEegESPLEAAL-KGAREIGFTVIAMTLTLVAVYlpiLFMGGLTGRLFREFAVTLAGAVIISGIV 475
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| YdfJ |
COG2409 |
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ... |
35-714 |
4.39e-172 |
|
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];
Pssm-ID: 441964 [Multi-domain] Cd Length: 697 Bit Score: 509.69 E-value: 4.39e-172
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 35 FFFPKAADYKDDAAKDLPNSEpSVVAQKLIDDKFAGTDGVPALITWYRSTG-LTTEDLVN-IQKYSKELTENPvDYQKMA 112
Cdd:COG2409 21 VLAPQLGGSLSSNGFFLPGSE-SQRAADLLAEAFPESDGASAVVVVEAPDGtLTDPAFRAaVAALVARLRADP-GVAGVQ 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 113 VPYDKMPPvalkQQVSKDGTTFIQTVIMKDSATsDQLTESFKQLESAAKTTigenpfaqkvsADDALVARTTGPAGISVD 192
Cdd:COG2409 99 DPWDDPAA----GLVSEDGKAALVTVTLDGDAG-DEAAEAVDALRDAVAAA-----------PAPGLTVYVTGPAALAAD 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 193 ASGLFKDADVSLLIGTVLLVLVFLLVIYRSPILALIPLIAVGFAYLVITPILGLLAKegIITYGSQGLSIMTVLLFGAGT 272
Cdd:COG2409 163 LNEAFEEDLGRAELITLPVALVVLLLVFRSLVAALLPLLTAGLAVGVALGLLALLAA--FTDVSSFAPNLLTMLGLGVGI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 273 DYCLFLISRFRSHLHTEKNRFQAFKEAFSGTAGAIALSGLTVMAALLLLLAAEYGSFHNFAVPFSLAIFIMMISSLTLVP 352
Cdd:COG2409 241 DYALFLVSRYREELRAGEDREEAVARAVATAGRAVLFSGLTVAIALLGLLLAGLPFLRSMGPAAAIGVAVAVLAALTLLP 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 353 ALLGIFGRVSFWPFVPRTLEMEETRakkkgktpkhhkeNRFWHKIGEMSAKHPVRILIITLIILIGCGIFTTQVKYTYDT 432
Cdd:COG2409 321 ALLALLGRRVFWPRRPRRRRAAAPE-------------SGFWRRLARAVVRRPVPVLVAAVAVLLALALPALGLRLGLPD 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 433 LSTFPEDMPSREGFTLISDHFGAGMLAPMEVVVNSKESM-----------KSSLENVDGVASVTGPERSKG----YQKYT 497
Cdd:COG2409 388 ADSLPADSPSRQGYDALAEHFPPGSNGPLTVVVESDDDLdpadlaaldalAAALAAVPGVASVQPPTRPEGtdgdAARLQ 467
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 498 LILKDNPYSNEAMDVVPKVRAAAD---KGNDVYIAGQTATQYDDRAVTEHDEKVIIPLVIALIAILLLCYLRSITAMLYL 574
Cdd:COG2409 468 VVPDGDPDSPEAIDLVDRLRDAAApalEGAEVLVGGTTAVNIDISDALADDLPLVIPVVLGLIFLLLLLLFRSVVAPLKA 547
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 575 VATVLLSFVGALGLGWVIIHYAMGV-----EAISGLIPLYAFVFIVALGEDYNIFMISSIWKNS-KKMPLRKAITEGVGQ 648
Cdd:COG2409 548 VLTNLLSLGAALGVLVLVFQHGWLLlgftpGPLDSFVPLLLFVILFGLGMDYEVFLVSRIREEYdRGGGTREAVIRGLAR 627
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1072179535 649 TGGVITSAGLILAGTFGVLTTLPIQLLVQFGLITAIGVLLDTFIVRPFLVPSITVLLGKWAFW-PGK 714
Cdd:COG2409 628 TGRVITSAALIMAAVFAAFATSPLVFLKQIGFGLAVGVLLDAFVVRMLLVPALMALLGRWNWWlPRW 694
|
|
| actII |
TIGR00833 |
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family ... |
33-492 |
1.97e-44 |
|
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family (TC 2.A.6.5)Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. This sub-family includes the S. coelicolor ActII3 protein, which may play a role in drug resistance, and the M. tuberculosis MmpL7 protein, which catalyzes export of an outer membrane lipid, phthiocerol dimycocerosate. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 129913 [Multi-domain] Cd Length: 910 Bit Score: 171.69 E-value: 1.97e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 33 LQFFFPKAAD--YKDDAAKdLPNSEPSVVAQKLIDDKFAGTDGVPALITW-YRSTGLTTEDLVNIQKYSKELTENPVDYQ 109
Cdd:TIGR00833 17 LQLLAPLLEDvsYFRLQAE-LPGGAASSIAVKEMSAAFQEAIRDPKIILVlESNERLGDKDYATYDALIAKLRADIMHVI 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 110 K----MAVPYdkMPPVAlkqqVSKDGTTFIQTVIMKDSATSDQLTESFKQLESAAKTTigenpfaqkvSADDALVARTTG 185
Cdd:TIGR00833 96 SvvdfWGPPE--AAEGL----RSDDGKATIIIVNLAGEKGQKEAQEAINAVRRIVEQT----------NAPDGLTVHVTG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 186 PAGISVDASGLFKDADVSLLIGTVLLVLVFLLVIYRSPILALIPLIAVGFAYLVITPILGLLAKEGIITYGSQGLSIMTV 265
Cdd:TIGR00833 160 PLATIADILESGDKDMNRITATTGIIVLIILLLVYRSPITMLVPLVSVGFSVVVAQGIVSLLGIPGLIGVNAQTTVLLTA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 266 LLFGAGTDYCLFLISRFRSHLHTEKNRFQAFKEAFSGTAGAIALSGLTVMAALLLLLAAEYGSFHNFAVPFSLAIFIMMI 345
Cdd:TIGR00833 240 LVIGAGTDYAVFLTGRYHEERRKGESLEEAAAEALRGTGKAILGSALTVAVAFLALSLARLPSFKTLGVSCAVGVLVALL 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 346 SSLTLVPALLGIFGRVSFWpfvprtlemeetrakkkgKTPKHHKENRFWHKIGEMSAKHPVRILIITLIILIGCGIFTTQ 425
Cdd:TIGR00833 320 NAVTLTPALLTLEGREGLM------------------KPGRKSKIRFIWRRLGTAVVRRPWPILVTTLIISGVSLLALPL 381
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1072179535 426 VKYTYDTLSTFPEDMPSREGFTLISDHFGAGMLAPMEVVVNSK------------ESMKSSLENVDGVASVTGPERSKG 492
Cdd:TIGR00833 382 IRTGYDDEKMIPTDLESVQGYEAADRHFPGNSMDPMVVMIKSDhdvrnpalladiDRFEREIKAVPGINMVQETQRPDG 460
|
|
| MMPL |
pfam03176 |
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ... |
51-406 |
3.08e-44 |
|
MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.
Pssm-ID: 308676 [Multi-domain] Cd Length: 332 Bit Score: 162.08 E-value: 3.08e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 51 LPNSEPSVVAQKLIDDKFAGTDGVPALITWYRSTGLTTEDLVNIQKYSKELTENPVDYQKMAVPYDKMP-PVALKQQVSK 129
Cdd:pfam03176 3 SPADAPSVRAMDRLGAAFPQADSDPIIVVVLGEGDQALGDAAAEAGYDTLVDALRADTGHVGSVQDFWGdPDTAALFVSP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 130 DGTTFIQTVIMKDSATSDQLTESFKQLESAAKTTIgenpfaqkvsADDALVARTTGPAGISVDASGLFKDADVSLLIGTV 209
Cdd:pfam03176 83 DGKAAYVVVTLEGDPGTTEADESVAAVRDAVEQAP----------PPEGLKAYLTGPAATVADLRDAGDRDLGLIEAVTL 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 210 LLVLVFLLVIYRSPILALIPLIAVGFAYLVITPILGLLAKEGIITYGSQGLSIMTVLLFGAGTDYCLFLISRFRSHLHTE 289
Cdd:pfam03176 153 VVIFIILLIVYRSVVAALLPLLTVGLSLGAAQGLVAILAHILGIGLSTFALNLLVVLLIAVGTDYALFLVSRYREELRAG 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 290 KNRFQAFKEAFSGTAGAIALSGLTVMAALLLLLAAEYGSFHNFAVPFSLAIFIMMISSLTLVPALLGIFGRVSFWPfvpr 369
Cdd:pfam03176 233 EDREEAVIRAVRGTGKVVTAAGLTVAIAMLALSFARLPVFAQVGPTIAIGVLVDVLAALTLLPALLALLGRWGLWP---- 308
|
330 340 350
....*....|....*....|....*....|....*..
gi 1072179535 370 tlemeetrakkkgktPKHHKENRFWHKIGEMSAKHPV 406
Cdd:pfam03176 309 ---------------PKRDRTARWWRRIGRLVVRRPA 330
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
219-708 |
2.30e-43 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 167.73 E-value: 2.30e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 219 IYRSPILALIPLIAVGFAyLVITpiLGLLAKEGI-ITYGSqglSIMTVLLFGAGTDYCLFLISRFRSHLHTEKNRFQAFK 297
Cdd:COG1033 238 FFRSLRGVLLPLLVVLLA-VIWT--LGLMGLLGIpLSPLT---ILVPPLLLAIGIDYGIHLLNRYREERRKGLDKREALR 311
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 298 EAFSGTAGAIALSGLTVMAALLLLLAAEYGSFHNFAVPFSLAIFIMMISSLTLVPALLGIFGRvsfwpfvprtlemeetR 377
Cdd:COG1033 312 EALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTSLTLLPALLSLLPR----------------P 375
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 378 AKKKGKTPKHHKENRFWHKIGEMSAKHPVRILIITLIILIGCGIFTTQVKYTYDTLSTFPEDMPSREGFTLISDHFGAGM 457
Cdd:COG1033 376 KPKTRRLKKPPELGRLLAKLARFVLRRPKVILVVALVLAVVSLYGISRLKVEYDFEDYLPEDSPIRQDLDFIEENFGGSD 455
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 458 laPMEVVVNSKES--------------MKSSLENVDGVASVTG----------------------PERSKGYQKYTLILK 501
Cdd:COG1033 456 --PLEVVVDTGEPdglkdpevlkeidrLQDYLESLPEVGKVLSladlvkelnqalnegdpkyyalPESRELLAQLLLLLS 533
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 502 DNPY------------------------SNEAMDVVPKVRAAADK-----GNDVYIAGQTATQYDDRAVTEHDEKVIIPL 552
Cdd:COG1033 534 SPPGddlsrfvdedysaarvtvrlkdldSEEIKALVEEVRAFLAEnfppdGVEVTLTGSAVLFAAINESVIESQIRSLLL 613
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 553 VIALIAILLLCYLRSITAMLYLVATVLLSFVGALGLgwviihyaMGVEAIsGLIPLYAFVFIVALG--EDYNIFMISSIW 630
Cdd:COG1033 614 ALLLIFLLLLLAFRSLRLGLISLIPNLLPILLTFGL--------MGLLGI-PLNIATAVVASIALGigVDYTIHFLSRYR 684
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1072179535 631 KNSKK-MPLRKAITEGVGQTGGVITSAGLILAGTFGVLTTLPIQLLVQFGLITAIGVLLdTFIVRPFLVPSITVLLGKW 708
Cdd:COG1033 685 EERRKgGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLV-ALLAALLLLPALLLLLDPR 762
|
|
| actII |
TIGR00833 |
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family ... |
503-712 |
1.44e-40 |
|
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family (TC 2.A.6.5)Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. This sub-family includes the S. coelicolor ActII3 protein, which may play a role in drug resistance, and the M. tuberculosis MmpL7 protein, which catalyzes export of an outer membrane lipid, phthiocerol dimycocerosate. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 129913 [Multi-domain] Cd Length: 910 Bit Score: 160.14 E-value: 1.44e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 503 NPYSNEAMDVVPKVRAAADKGND--------VYIAGQTATQYDDRAVTEHDEKVIIPLVIALIAILLLCYLRSITAMLYL 574
Cdd:TIGR00833 695 SPAGDQGAQEFNAIRTVAEEAIQradlepakVELAGVSAVNRDLRDLVNSDLGLISIITLAIVFMILALLLRAPVAPIVL 774
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 575 VATVLLSFVGALGLGWVIIHYAMGVEAISgLIPLYAFVFIVALGEDYNIFMISSIWKNSKKMPlRKAITEGVGQTGGVIT 654
Cdd:TIGR00833 775 IGSVALSYLWALGLSVLAFQHILGAELHW-SVLAGVFVLLVALGVDYNMLLVSRIKEESPAGN-RTGIIRALGSTGGVIT 852
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 1072179535 655 SAGLILAGTFGVLTTLPIQLLVQFGLITAIGVLLDTFIVRPFLVPSITVLLGKWAFWP 712
Cdd:TIGR00833 853 AAGLVFAGTMAALASAQLTAIAQFGFTVGVGILLDTFIVRSVTVPALTLLLGRWIWWP 910
|
|
| MMPL |
pfam03176 |
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ... |
500-719 |
9.74e-38 |
|
MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.
Pssm-ID: 308676 [Multi-domain] Cd Length: 332 Bit Score: 143.59 E-value: 9.74e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 500 LKDNPYSNEAMDVVPKVRAAADK-----GNDVYIAGQTATQYDDRAVTEHDEKVIIPLVIALIAILLLCYLRSITAMLYL 574
Cdd:pfam03176 93 LEGDPGTTEADESVAAVRDAVEQapppeGLKAYLTGPAATVADLRDAGDRDLGLIEAVTLVVIFIILLIVYRSVVAALLP 172
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 575 VATVLLSFVGALGLGWVIIHyaMGVEAISGLIPLYAFVFIVALGEDYNIFMISSIWKNSKKMPLRK-AITEGVGQTGGVI 653
Cdd:pfam03176 173 LLTVGLSLGAAQGLVAILAH--ILGIGLSTFALNLLVVLLIAVGTDYALFLVSRYREELRAGEDREeAVIRAVRGTGKVV 250
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1072179535 654 TSAGLILAGTFGVLTTLPIQLLVQFGLITAIGVLLDTFIVRPFLvPSITVLLGKWAFWPGKQHKMT 719
Cdd:pfam03176 251 TAAGLTVAIAMLALSFARLPVFAQVGPTIAIGVLVDVLAALTLL-PALLALLGRWGLWPPKRDRTA 315
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
391-709 |
3.70e-28 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 120.73 E-value: 3.70e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 391 NRFWHKIGEMSAKHPVRILIITLIILIGCGIFTTQVKYTYDTLSTFPEDMPSREGFTLISDHFGAGmlAPMEVVVNSKES 470
Cdd:COG1033 1 ERLMERLARFILRHRKLVLLLFLLLTLLLAYGAPKLEVDTDFESLLPEDDPSVQAYDEFEEEFGGD--DTVVVAVEGKDD 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 471 MKS------------SLENVDGVASVTGP-------------------------------------ERSKGYQ------- 494
Cdd:COG1033 79 IFTpetlealrelteELEEIPGVDSVTSLtnvrategtedgltveplipdelpaspeelaelrekvLSSPLYVgrlvspd 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 495 -KYTLI---LKDNPYSN--EAMDVVPKVRAAADK----GNDVYIAGQTATQYDDRAVTEHDEKVIIPLVIALIAILLLCY 564
Cdd:COG1033 159 gKATLIvvtLDPDPLSSdlDRKEVVAEIRAIIAKyedpGVEVYLTGFPVLRGDIAEAIQSDLAIFFPLALLLILLLLFLF 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 565 LRSITAMLYLVATVLLSFVGALGL-GWVIIHyamgVEAISGLIPlyafVFIVALGEDYNIFMISSIWKNSKK-MPLRKAI 642
Cdd:COG1033 239 FRSLRGVLLPLLVVLLAVIWTLGLmGLLGIP----LSPLTILVP----PLLLAIGIDYGIHLLNRYREERRKgLDKREAL 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1072179535 643 TEGVGQTGGVITSAGLILAGTFGVLTTLPIQLLVQFGLITAIGVLLdTFIVRPFLVPSITVLLGKWA 709
Cdd:COG1033 311 REALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLL-AFLTSLTLLPALLSLLPRPK 376
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
105-704 |
1.61e-25 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 112.24 E-value: 1.61e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 105 PVDYQKMAVPYDKMPPVAlKQQVSKDGTTFIQTVIMKDSATSDQLTESFKQLESAakttIGENPFAQkvsaddALVARTT 184
Cdd:TIGR00921 110 PVTMPEVRPLMSEYPRSK-EMFLSKDHTVAIIIVQLKSDADYKQVVPIYNDVERS----LERTNPPS------GKFLDVT 178
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 185 GPAGISVD-ASGLFKDADVSLLIgTVLLVLVFLLVIYRSPILALIPLIAVGFAYLVITPILGLLakeGIITYGSQGLSIm 263
Cdd:TIGR00921 179 GSPAINYDiEREFGKDMGTTMAI-SGILVVLVLLLDFKRWWRPLLPLVIILFGVAWVLGIMGWL---GIPLYATTLLAV- 253
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 264 tVLLFGAGTDYCLFLISRFRSHLHTEKNRFQAFKEAFSGTAGAIALSGLTVMAALLLLLAAEYGSFHNFAVPFSLAIFIM 343
Cdd:TIGR00921 254 -PMLIGVGIDYGIQTLNRYEEERDIGRAKGEAIVTAVRRTGRAVLIALLTTSAGFAALALSEFPMVSEFGLGLVAGLITA 332
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 344 MISSLTLVPALLGIFgrvsfwPFVPRTLEME-ETRAKKKGKtpkhhKENRFWhKIGEMSAKHPVRILIITLIILIGCGIF 422
Cdd:TIGR00921 333 YLLTLLVLPALLQSI------DIGREKVKKEiIAIGGKSSE-----IEEELS-KVLSITVRHPVPALVAALIITGLGLYG 400
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 423 TTQVKYTYDTLSTFPEDMPSREGFTLISDHFGAGMLAPMEVVVNSKES----------------MKSSLENVDGVASVTG 486
Cdd:TIGR00921 401 AAGIKPEVNIEKFIPQDLPSLQARKVIESHMGGSHDFATILVKADDVRdpelvrfmdelsrdikATGVAARVFGAPSIID 480
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 487 --PERSKGYQKYTLILKDNPYSNEAM-----DVVPKVRAAADK----------------------GNDVYIAGQTATQYD 537
Cdd:TIGR00921 481 lvKEVEGLPAPERSALEPIPEDEEGGyisggQIKVAVIQVQLKqgepkvqgrkilrdvqhehpppGVKVGVTGLPVAFAE 560
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 538 -DRAVTEHDEKVIIPLVIALIAILLLCYLRSITAMLYLVATVllsfvgaLGLGWVI-IHYAMGVEAISGLIPLYAfvFIV 615
Cdd:TIGR00921 561 mHELVNEGMRRMTIAGAILVLMILLAVFRNPIKAVFPLIAIG-------SGILWAIgLMGLRGIPSFLAMATTIS--IIL 631
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 616 ALGEDYNIFMISSIWKNSKKMPLRKAITEGVGQTGGVITSAGLILAGTFGVLTTLPIQLLVQFGLITAIGVLLdTFIVRP 695
Cdd:TIGR00921 632 GLGMDYSIHLAERYFEERKEHGPKEAITHTMERTGPGILFSGLTTAGGFLSLLLSHFPIMRNFGLVQGIGVLS-SLTAAL 710
|
....*....
gi 1072179535 696 FLVPSITVL 704
Cdd:TIGR00921 711 VVFPALLVL 719
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
45-360 |
2.97e-18 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 89.53 E-value: 2.97e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 45 DDAAKDLPNSEPSVVAQKLIDDKFAGTDGVPALITWYRSTGLTTED-LVNIQKYSKELTENP--------VDYQKM---- 111
Cdd:COG1033 428 YDFEDYLPEDSPIRQDLDFIEENFGGSDPLEVVVDTGEPDGLKDPEvLKEIDRLQDYLESLPevgkvlslADLVKElnqa 507
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 112 ---------AVP------------YDKMPPVALKQQVSKDGTTFIQTVIMKDsATSDQLTESFKQLESaakttigenpFA 170
Cdd:COG1033 508 lnegdpkyyALPesrellaqllllLSSPPGDDLSRFVDEDYSAARVTVRLKD-LDSEEIKALVEEVRA----------FL 576
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 171 QKVSADDALVARTTGPAGISVDASG-LFKDADVSLLIgTVLLVLVFLLVIYRSPILALIPLIAVGFAYLVITPILGLLak 249
Cdd:COG1033 577 AENFPPDGVEVTLTGSAVLFAAINEsVIESQIRSLLL-ALLLIFLLLLLAFRSLRLGLISLIPNLLPILLTFGLMGLL-- 653
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 250 eGIitygsqGLSIMTVLL----FGAGTDYCLFLISRFRSHLHTEKNRFQAFKEAFSGTAGAIALSGLTVMAALLLLLAAE 325
Cdd:COG1033 654 -GI------PLNIATAVVasiaLGIGVDYTIHFLSRYREERRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSS 726
|
330 340 350
....*....|....*....|....*....|....*
gi 1072179535 326 YGSFHNFAVPFSLAIFIMMISSLTLVPALLGIFGR 360
Cdd:COG1033 727 FPPLADFGLLLALGLLVALLAALLLLPALLLLLDP 761
|
|
| YdfJ |
COG2409 |
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ... |
401-712 |
3.73e-18 |
|
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];
Pssm-ID: 441964 [Multi-domain] Cd Length: 697 Bit Score: 89.05 E-value: 3.73e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 401 SAKHPVRILIITLIILIGCGIFTTQVKYTYDTLSTFPEDMPSREGFTLISDHFGAGMLAPMEVVVNSK------------ 468
Cdd:COG2409 1 VARHRWLVLLAWLVLLVALGVLAPQLGGSLSSNGFFLPGSESQRAADLLAEAFPESDGASAVVVVEAPdgtltdpafraa 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 469 -ESMKSSLENVDGVASVTGPERSKGYQK--------YTLILKDNPYSNEAMDVVPKVRAAADK----GNDVYIAGQTATQ 535
Cdd:COG2409 81 vAALVARLRADPGVAGVQDPWDDPAAGLvsedgkaaLVTVTLDGDAGDEAAEAVDALRDAVAAapapGLTVYVTGPAALA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 536 YDDRAVTEHDEKVIIPLVIALIAILLLCYLRSITAMLYLVATVLLSFVGALGLGWVIIHYAmgveAISGLIPLYAFVFIV 615
Cdd:COG2409 161 ADLNEAFEEDLGRAELITLPVALVVLLLVFRSLVAALLPLLTAGLAVGVALGLLALLAAFT----DVSSFAPNLLTMLGL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 616 ALGEDYNIFMISSiWKN--SKKMPLRKAITEGVGQTGGVITSAGLILAGTFGVLTTLPIQLLVQFGLITAIGVLLdTFIV 693
Cdd:COG2409 237 GVGIDYALFLVSR-YREelRAGEDREEAVARAVATAGRAVLFSGLTVAIALLGLLLAGLPFLRSMGPAAAIGVAV-AVLA 314
|
330
....*....|....*....
gi 1072179535 694 RPFLVPSITVLLGKWAFWP 712
Cdd:COG2409 315 ALTLLPALLALLGRRVFWP 333
|
|
| actII |
TIGR00833 |
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family ... |
72-365 |
2.72e-07 |
|
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family (TC 2.A.6.5)Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. This sub-family includes the S. coelicolor ActII3 protein, which may play a role in drug resistance, and the M. tuberculosis MmpL7 protein, which catalyzes export of an outer membrane lipid, phthiocerol dimycocerosate. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 129913 [Multi-domain] Cd Length: 910 Bit Score: 54.21 E-value: 2.72e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 72 DGVPALITWYRSTGLTTEDLVN-IQKYSKEL-----TENPVD-YQKMAVPYDKMPPVALKQQVSKDGTTFIQTVIMKDSA 144
Cdd:TIGR00833 617 DGIGTQLAQMRESAAGVQDLLNeLSDYSMTMgklkgNAMGVDfYAPPRIFTDPNFKAVLDYFLSPDGHAARLLVYGDGSP 696
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 145 TSDQLTESFKQLESAAKTTIGENPFaqkvsaDDALVaRTTGPAGISVDASGLFKDADVSLLIGTVLLVLVFLLVIYRSPI 224
Cdd:TIGR00833 697 AGDQGAQEFNAIRTVAEEAIQRADL------EPAKV-ELAGVSAVNRDLRDLVNSDLGLISIITLAIVFMILALLLRAPV 769
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 225 --------LALIPLIAVGFAYLVITPILGLLAKEGIitygsqgLSIMTVLLFGAGTDYCLFLISRFRSHLHtEKNRFQAF 296
Cdd:TIGR00833 770 apivligsVALSYLWALGLSVLAFQHILGAELHWSV-------LAGVFVLLVALGVDYNMLLVSRIKEESP-AGNRTGII 841
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 297 KeAFSGTAGAIALSGLTVMAALLLLLAAEYGSFHNFAVPFSLAIFI-MMISSLTLVPALLGIFGRVSFWP 365
Cdd:TIGR00833 842 R-ALGSTGGVITAAGLVFAGTMAALASAQLTAIAQFGFTVGVGILLdTFIVRSVTVPALTLLLGRWIWWP 910
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
513-700 |
8.33e-07 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 52.55 E-value: 8.33e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 513 VPKVRAAADKGNDVYI------AGQTATQYDDRAVTehdekvIIPLVIALIAILLLCYLRSITAMLYLVATVLLSFVGAL 586
Cdd:COG4258 608 AAALRAAAAGLPGVRLvdrkaeSSSLFGRYRNDALW------LLLLALLLILLLLLLRLRSLRRALRVLLPPLLAVLLTL 681
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 587 G-LGWViiHYAMGVEAISGLIplyafvFIVALGEDYNIFMissiwknskkmplrkaiTEGVGQTGGVITS-AGLILAG-- 662
Cdd:COG4258 682 AiLGLL--GIPLNLFHLIALL------LVLGIGIDYALFF-----------------TEGLLDKGELARTlLSILLAAlt 736
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 1072179535 663 ---TFGVLTTLPIQLLVQFGLITAIGVLLdTFIVRPFLVPS 700
Cdd:COG4258 737 tllGFGLLAFSSTPALRSFGLTVLLGILL-ALLLAPLLAPR 776
|
|
| HpnN |
TIGR03480 |
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ... |
508-705 |
2.84e-05 |
|
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.
Pssm-ID: 274598 [Multi-domain] Cd Length: 862 Bit Score: 47.68 E-value: 2.84e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 508 EAMDVVPKV----RAAADKGNDVYIAGQTATQYDDRAVTEHDEKVIIPLVIALIAILLLCYLRSitamLYLVATVLLSFV 583
Cdd:TIGR03480 229 KAINAIRAAakdlRLDEDHGVTVRLTGEVALSDEELATVSEGATVAGLLSFVLVLVLLWLALRS----PRLVFAVLVTLI 304
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 584 GALglgwvIIHYAMGVEAISGLIPL-YAF-VFIVALGEDYNI-FMISSIWKNSKKMPLRKAITEGVGQTGGVITSAGLIL 660
Cdd:TIGR03480 305 VGL-----ILTAAFATLAVGHLNLIsVAFaVLFIGLGVDFAIqFSLRYREERFRGGNHREALSVAARRMGAALLLAALAT 379
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 1072179535 661 AgtFGVLTTLPIQL--LVQFGLITAIGVLLDTFIVRPFLvPSITVLL 705
Cdd:TIGR03480 380 A--AGFFAFLPTDYkgVSELGIIAGTGMFIALFVTLTVL-PALLRLL 423
|
|
| HpnN |
TIGR03480 |
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ... |
153-358 |
1.55e-04 |
|
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.
Pssm-ID: 274598 [Multi-domain] Cd Length: 862 Bit Score: 44.99 E-value: 1.55e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 153 FKQLESAAK--TTIGENPFAQKVSADDALVARTTGPAGISVDA-SGLFKDADVSLLIGTVllvlvfllviyrspILALIP 229
Cdd:TIGR03480 221 YSSLEPAEKaiNAIRAAAKDLRLDEDHGVTVRLTGEVALSDEElATVSEGATVAGLLSFV--------------LVLVLL 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 230 LIAVGFAYLV----ITPILGLLAKEGI--ITYGSQGL-SI-MTVLLFGAGTDYCLFLISRFRSHLHTEKNRFQAFKEAFS 301
Cdd:TIGR03480 287 WLALRSPRLVfavlVTLIVGLILTAAFatLAVGHLNLiSVaFAVLFIGLGVDFAIQFSLRYREERFRGGNHREALSVAAR 366
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1072179535 302 GTAGAIALSGLTVMAalllllaaeygSFHNFaVPFSLA------------IFIMMISSLTLVPALLGIF 358
Cdd:TIGR03480 367 RMGAALLLAALATAA-----------GFFAF-LPTDYKgvselgiiagtgMFIALFVTLTVLPALLRLL 423
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
539-714 |
1.71e-03 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 41.76 E-value: 1.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 539 RAVTEHDEKVIIPLVIALIAILLLCYLRSITAMLYLVATVLlsfVGALgLGWVIIHYAMGveAISGLiplyAFVF-IVAL 617
Cdd:COG4258 244 AQQIKHDISTIGLISLLGILLLLLLVFRSLRPLLLGLLPVA---VGAL-AGLAAVSLVFG--SVHGI----TLGFgSSLI 313
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 618 GE--DYNIFMISSIWKNSKKMP--LRKAITEGVgqTGGVITSAgliLAgtFGVLTTLPIQLLVQFGLITAIGVL---LDT 690
Cdd:COG4258 314 GVavDYSLHYLTHRRAAGEWDPraALRRIWPTL--LLGLLTTV---LG--YLALLFSPFPGLRQLGVFAAAGLLaaaLTT 386
|
170 180 190
....*....|....*....|....*....|...
gi 1072179535 691 FIVRPFLVPSITV--------LLGKW-AFWPGK 714
Cdd:COG4258 387 LLWLPLLLPRAAPrppapalaLLARLlARWPRR 419
|
|
| RND_permease_2 |
NF033617 |
multidrug efflux RND transporter permease subunit; |
546-692 |
3.93e-03 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 411236 [Multi-domain] Cd Length: 1009 Bit Score: 40.77 E-value: 3.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072179535 546 EKVIIPLVIALIAILLLCYL--RSITAMLYLVATVLLSFVGALGLgwviiHYAMGVEAisGLIPLYAFVFIVALGEDYNI 623
Cdd:NF033617 330 DEVESTLLEAVALVILVVFLflRNLRATLIPAVTVPLSLIGTFAV-----MYLFGFSI--NLLTLMALVLAIGLVVDDAI 402
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1072179535 624 FMISSIWKNSK--KMPLRKAItEGVGQTGGVITSAGLILAGTF---GVLTTLPIQLLVQFGLITAIGVLLDTFI 692
Cdd:NF033617 403 VVVENIHRHIEegESPLEAAL-KGAREIGFTVIAMTLTLVAVYlpiLFMGGLTGRLFREFAVTLAGAVIISGIV 475
|
|
| |
