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Conserved domains on  [gi|1071575469|gb|OEP36889|]
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phosphoribosylaminoimidazolesuccinocarboxamide synthase [Listeria monocytogenes]

Protein Classification

phosphoribosylaminoimidazolesuccinocarboxamide synthase( domain architecture ID 10013199)

phosphoribosylaminoimidazolesuccinocarboxamide synthase catalyzes the conversion of 5-aminoimidazole-4-carboxyribonucleotide (CAIR) to 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) in the de novo biosynthesis of purine nucleotides

EC:  6.3.2.6
Gene Ontology:  GO:0005524|GO:0004639

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PRK09362 PRK09362
phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed
 1-235 2.58e-145

phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed


:

Pssm-ID: 181800  Cd Length: 238  Bit Score: 405.26  E-value: 2.58e-145
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071575469   1 MTNELVYEGKAKRLFKTEEAGVLRVAYKDDATALNGVRKESFAGKGELNNQITSLIFSHLAEAGIESHFIRAISETEQLV 80
Cdd:PRK09362    2 EKKELLYEGKAKIVYSTDDPDLLIVEFKDDATAFNGEKKEQIDGKGVLNNQISSFIFKKLEEAGIPTHFIEKLSDREQLV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071575469  81 KEVSIIPLEVVVRNVMAGSLAKRLGKEEGEPIPNAIVEFYYKDDALDDPFINDDHVLYLEVATTSEMDTIRQAARSINKV 160
Cdd:PRK09362   82 KKVEIIPLEVVVRNVAAGSLVKRLGIEEGTVLPPPIVEFYYKNDALGDPMINEDHILALGWATPEELAEIKELALKINDV 161

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1071575469 161 LQELFNQMNITLIDFKLEFGRDAAGEILLADEISPDTCRLWDKETNQKLDKDVFRRNIGNLTDVYTEVLNRLKQV 235
Cdd:PRK09362  162 LKGLFAGAGIRLVDFKLEFGRDKDGEIVLADEISPDTCRLWDKETNEKLDKDRFRRDLGGVIEAYEEVLKRLGEL 236
 
Name Accession Description Interval E-value
PRK09362 PRK09362
phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed
 1-235 2.58e-145

phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed


Pssm-ID: 181800  Cd Length: 238  Bit Score: 405.26  E-value: 2.58e-145
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071575469   1 MTNELVYEGKAKRLFKTEEAGVLRVAYKDDATALNGVRKESFAGKGELNNQITSLIFSHLAEAGIESHFIRAISETEQLV 80
Cdd:PRK09362    2 EKKELLYEGKAKIVYSTDDPDLLIVEFKDDATAFNGEKKEQIDGKGVLNNQISSFIFKKLEEAGIPTHFIEKLSDREQLV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071575469  81 KEVSIIPLEVVVRNVMAGSLAKRLGKEEGEPIPNAIVEFYYKDDALDDPFINDDHVLYLEVATTSEMDTIRQAARSINKV 160
Cdd:PRK09362   82 KKVEIIPLEVVVRNVAAGSLVKRLGIEEGTVLPPPIVEFYYKNDALGDPMINEDHILALGWATPEELAEIKELALKINDV 161

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1071575469 161 LQELFNQMNITLIDFKLEFGRDAAGEILLADEISPDTCRLWDKETNQKLDKDVFRRNIGNLTDVYTEVLNRLKQV 235
Cdd:PRK09362  162 LKGLFAGAGIRLVDFKLEFGRDKDGEIVLADEISPDTCRLWDKETNEKLDKDRFRRDLGGVIEAYEEVLKRLGEL 236
SAICAR_synt_PurC cd01415
bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) ...
 5-234 4.42e-138

bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; A subfamily of SAICAR synthetases represented by the Thermotoga maritima (Tm) enzyme and E. coli PurC. SAICAR synthetase catalyzes the seventh step of the de novo biosynthesis of purine nucleotides (also reported as eighth step). It converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.


Pssm-ID: 133470  Cd Length: 230  Bit Score: 386.42  E-value: 4.42e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071575469   5 LVYEGKAKRLFKTEEAGVLRVAYKDDATALNGVRKESFAGKGELNNQITSLIFSHLAEAGIESHFIRAISETEQLVKEVS 84
Cdd:cd01415     1 LLYEGKAKIVYATDDPDVLIVEFKDDATAFNGKKKDTIEGKGVLNNEISALIFKYLEENGIKTHFIEKLSDREQLVKKVE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071575469  85 IIPLEVVVRNVMAGSLAKRLGKEEGEPIPNAIVEFYYKDDALDDPFINDDHVLYLEVATTSEMDTIRQAARSINKVLQEL 164
Cdd:cd01415    81 IIPLEVVVRNIAAGSLVKRLGIEEGTVLDPPIVEFYYKNDELGDPLINEDHILALGLATEEELKEIKELALKINEVLSEF 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071575469 165 FNQMNITLIDFKLEFGRDAAGEILLADEISPDTCRLWDKETNQKLDKDVFRRNIGNLTDVYTEVLNRLKQ 234
Cdd:cd01415   161 FAEIGIILVDFKLEFGRDKDGEIVLADEISPDTCRLWDKETGEKLDKDRFRRDLGDVIEAYEEVLKRLGE 230
SAICAR_synt pfam01259
SAICAR synthetase; Also known as Phosphoribosylaminoimidazole-succinocarboxamide synthase.
 5-227 3.99e-117

SAICAR synthetase; Also known as Phosphoribosylaminoimidazole-succinocarboxamide synthase.


Pssm-ID: 460140  Cd Length: 228  Bit Score: 333.56  E-value: 3.99e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071575469   5 LVYEGKAKRLFKTEEAGVLRVAYKDDATALNGVRKESFAGKGELNNQITSLIFSHLAEAGIESHFIRAISETEQLVKEVS 84
Cdd:pfam01259   1 LLYEGKVKDVYETDDPDTLLVVAKDRISAFDGVKKGTIPGKGAVNNQISAFWFELLEIAGIPTHFIKSLSGREMLVKKVK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071575469  85 IIPLEVVVRNVMAGSLAKRL-GKEEGEPIPNAIVEFYYKDDALDDPFINDDHVLYLEVATTSEMDTIRQAARSINKVLQE 163
Cdd:pfam01259  81 IIPLEVVVRNYAAGSLGKRLpGLKEGTKLPEPIFEPSTKADALGDPNINEEHIVALGLATEEEAEEIRELALKINEILKE 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1071575469 164 LFNQMNITLIDFKLEFGRDAAGEILLADEISPDTCRLWDKET----NQKLDKDVFRRNIGNLTDVYTE 227
Cdd:pfam01259 161 YAAERGIILVDTKLEFGLDSDGEIVLADEITPDSSRFWDADTyeksQESLDKDRFRDDLGDVEEAYQE 228
PurC COG0152
Phosphoribosylaminoimidazole-succinocarboxamide synthase [Nucleotide transport and metabolism]; ...
 4-232 6.28e-114

Phosphoribosylaminoimidazole-succinocarboxamide synthase [Nucleotide transport and metabolism]; Phosphoribosylaminoimidazole-succinocarboxamide synthase is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439922  Cd Length: 245  Bit Score: 325.88  E-value: 6.28e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071575469   4 ELVYEGKAKRLFKTEEaGVLRVAYKDDATALNGVRKESFAGKGELNNQITSLIFSHLAEAGIESHFIRAISETEQLVKEV 83
Cdd:COG0152     5 ELLYEGKVKDVYATDD-DTLLMVFKDRISAFDGVKPDPIPGKGEVLNQISAFWFELLEDIGIPTHFIETLSGREMLVKKL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071575469  84 SIIPLEVVVRNVMAGSLAKR--------LGKEEGEPIPNAIVEFYYKDDALDDPFINDDHVLYLEVATTSEMDTIRQAAR 155
Cdd:COG0152    84 EMIPVEVVVRNYAAGSLWKRyqagialpLGLEEGTKLPEPIFEPSTKADEGHDPNISEEHIVALGLATEEEAEELRELAL 163

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1071575469 156 SINKVLQELFNQMNITLIDFKLEFGRDAAGEILLADEISPDTCRLWDKETNQKLDKDVFRRNIGNLT-DVYTEVLNRL 232
Cdd:COG0152   164 KINERLSELAAERGIILVDTKLEFGRDADGEIVLADEITPDSSRLWDADTYESLDKDRFRDWLGGNTsEAYIEVLERL 241
purC TIGR00081
phosphoribosylaminoimidazole-succinocarboxamide synthase; Alternate name: SAICAR synthetase ...
 2-228 1.32e-92

phosphoribosylaminoimidazole-succinocarboxamide synthase; Alternate name: SAICAR synthetase purine de novo biosynthesis. E.coli example noted as homotrimer. Check length. Longer versions may be multifunctional enzymes. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 272897  Cd Length: 237  Bit Score: 271.58  E-value: 1.32e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071575469   2 TNELVYEGKAKRLFKTEEAGVLRVAYKDDATALNGVRKESFAGKGELNNQITSLIFSHLAEAGIESHFIRAISETEQLVK 81
Cdd:TIGR00081   5 KRQKLYSGKAKDIYETDDPDLLRFVFRDDISAFDGEKKDQIPGKGRLNTKISAFIFEKLEEAGIPTHYIDLIEDREMLVK 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071575469  82 EVSIIPLEVVVRNVMAGSLAKRLGKEEGEPIPNAIVEFYYKDDALDDPFINDDHVLYLEVATTSEMDTIRQAARSINKVL 161
Cdd:TIGR00081  85 KLDIIPLEVIVRNIAAGSLLKRLGIPEGLELEQPLVEFIFKPDEVGDPMLNESYAEALGLATEEELERIKELALKVNEVL 164

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1071575469 162 QELFNQMNITLIDFKLEFGRDAAGEILLADEISPDTCRLWDKETNQ----KLDKDVFRRNIGNLTDVYTEV 228
Cdd:TIGR00081 165 KKYFDEKGIILVDFKLEFGLDEEGNLILADEVSPDTCRLWDKETYEvgapKLDKDIFRRTLGKLIEAYETV 235
 
Name Accession Description Interval E-value
PRK09362 PRK09362
phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed
 1-235 2.58e-145

phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed


Pssm-ID: 181800  Cd Length: 238  Bit Score: 405.26  E-value: 2.58e-145
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071575469   1 MTNELVYEGKAKRLFKTEEAGVLRVAYKDDATALNGVRKESFAGKGELNNQITSLIFSHLAEAGIESHFIRAISETEQLV 80
Cdd:PRK09362    2 EKKELLYEGKAKIVYSTDDPDLLIVEFKDDATAFNGEKKEQIDGKGVLNNQISSFIFKKLEEAGIPTHFIEKLSDREQLV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071575469  81 KEVSIIPLEVVVRNVMAGSLAKRLGKEEGEPIPNAIVEFYYKDDALDDPFINDDHVLYLEVATTSEMDTIRQAARSINKV 160
Cdd:PRK09362   82 KKVEIIPLEVVVRNVAAGSLVKRLGIEEGTVLPPPIVEFYYKNDALGDPMINEDHILALGWATPEELAEIKELALKINDV 161

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1071575469 161 LQELFNQMNITLIDFKLEFGRDAAGEILLADEISPDTCRLWDKETNQKLDKDVFRRNIGNLTDVYTEVLNRLKQV 235
Cdd:PRK09362  162 LKGLFAGAGIRLVDFKLEFGRDKDGEIVLADEISPDTCRLWDKETNEKLDKDRFRRDLGGVIEAYEEVLKRLGEL 236
SAICAR_synt_PurC cd01415
bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) ...
 5-234 4.42e-138

bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; A subfamily of SAICAR synthetases represented by the Thermotoga maritima (Tm) enzyme and E. coli PurC. SAICAR synthetase catalyzes the seventh step of the de novo biosynthesis of purine nucleotides (also reported as eighth step). It converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.


Pssm-ID: 133470  Cd Length: 230  Bit Score: 386.42  E-value: 4.42e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071575469   5 LVYEGKAKRLFKTEEAGVLRVAYKDDATALNGVRKESFAGKGELNNQITSLIFSHLAEAGIESHFIRAISETEQLVKEVS 84
Cdd:cd01415     1 LLYEGKAKIVYATDDPDVLIVEFKDDATAFNGKKKDTIEGKGVLNNEISALIFKYLEENGIKTHFIEKLSDREQLVKKVE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071575469  85 IIPLEVVVRNVMAGSLAKRLGKEEGEPIPNAIVEFYYKDDALDDPFINDDHVLYLEVATTSEMDTIRQAARSINKVLQEL 164
Cdd:cd01415    81 IIPLEVVVRNIAAGSLVKRLGIEEGTVLDPPIVEFYYKNDELGDPLINEDHILALGLATEEELKEIKELALKINEVLSEF 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071575469 165 FNQMNITLIDFKLEFGRDAAGEILLADEISPDTCRLWDKETNQKLDKDVFRRNIGNLTDVYTEVLNRLKQ 234
Cdd:cd01415   161 FAEIGIILVDFKLEFGRDKDGEIVLADEISPDTCRLWDKETGEKLDKDRFRRDLGDVIEAYEEVLKRLGE 230
SAICAR_synt pfam01259
SAICAR synthetase; Also known as Phosphoribosylaminoimidazole-succinocarboxamide synthase.
 5-227 3.99e-117

SAICAR synthetase; Also known as Phosphoribosylaminoimidazole-succinocarboxamide synthase.


Pssm-ID: 460140  Cd Length: 228  Bit Score: 333.56  E-value: 3.99e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071575469   5 LVYEGKAKRLFKTEEAGVLRVAYKDDATALNGVRKESFAGKGELNNQITSLIFSHLAEAGIESHFIRAISETEQLVKEVS 84
Cdd:pfam01259   1 LLYEGKVKDVYETDDPDTLLVVAKDRISAFDGVKKGTIPGKGAVNNQISAFWFELLEIAGIPTHFIKSLSGREMLVKKVK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071575469  85 IIPLEVVVRNVMAGSLAKRL-GKEEGEPIPNAIVEFYYKDDALDDPFINDDHVLYLEVATTSEMDTIRQAARSINKVLQE 163
Cdd:pfam01259  81 IIPLEVVVRNYAAGSLGKRLpGLKEGTKLPEPIFEPSTKADALGDPNINEEHIVALGLATEEEAEEIRELALKINEILKE 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1071575469 164 LFNQMNITLIDFKLEFGRDAAGEILLADEISPDTCRLWDKET----NQKLDKDVFRRNIGNLTDVYTE 227
Cdd:pfam01259 161 YAAERGIILVDTKLEFGLDSDGEIVLADEITPDSSRFWDADTyeksQESLDKDRFRDDLGDVEEAYQE 228
PurC COG0152
Phosphoribosylaminoimidazole-succinocarboxamide synthase [Nucleotide transport and metabolism]; ...
 4-232 6.28e-114

Phosphoribosylaminoimidazole-succinocarboxamide synthase [Nucleotide transport and metabolism]; Phosphoribosylaminoimidazole-succinocarboxamide synthase is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439922  Cd Length: 245  Bit Score: 325.88  E-value: 6.28e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071575469   4 ELVYEGKAKRLFKTEEaGVLRVAYKDDATALNGVRKESFAGKGELNNQITSLIFSHLAEAGIESHFIRAISETEQLVKEV 83
Cdd:COG0152     5 ELLYEGKVKDVYATDD-DTLLMVFKDRISAFDGVKPDPIPGKGEVLNQISAFWFELLEDIGIPTHFIETLSGREMLVKKL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071575469  84 SIIPLEVVVRNVMAGSLAKR--------LGKEEGEPIPNAIVEFYYKDDALDDPFINDDHVLYLEVATTSEMDTIRQAAR 155
Cdd:COG0152    84 EMIPVEVVVRNYAAGSLWKRyqagialpLGLEEGTKLPEPIFEPSTKADEGHDPNISEEHIVALGLATEEEAEELRELAL 163

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1071575469 156 SINKVLQELFNQMNITLIDFKLEFGRDAAGEILLADEISPDTCRLWDKETNQKLDKDVFRRNIGNLT-DVYTEVLNRL 232
Cdd:COG0152   164 KINERLSELAAERGIILVDTKLEFGRDADGEIVLADEITPDSSRLWDADTYESLDKDRFRDWLGGNTsEAYIEVLERL 241
purC TIGR00081
phosphoribosylaminoimidazole-succinocarboxamide synthase; Alternate name: SAICAR synthetase ...
 2-228 1.32e-92

phosphoribosylaminoimidazole-succinocarboxamide synthase; Alternate name: SAICAR synthetase purine de novo biosynthesis. E.coli example noted as homotrimer. Check length. Longer versions may be multifunctional enzymes. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 272897  Cd Length: 237  Bit Score: 271.58  E-value: 1.32e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071575469   2 TNELVYEGKAKRLFKTEEAGVLRVAYKDDATALNGVRKESFAGKGELNNQITSLIFSHLAEAGIESHFIRAISETEQLVK 81
Cdd:TIGR00081   5 KRQKLYSGKAKDIYETDDPDLLRFVFRDDISAFDGEKKDQIPGKGRLNTKISAFIFEKLEEAGIPTHYIDLIEDREMLVK 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071575469  82 EVSIIPLEVVVRNVMAGSLAKRLGKEEGEPIPNAIVEFYYKDDALDDPFINDDHVLYLEVATTSEMDTIRQAARSINKVL 161
Cdd:TIGR00081  85 KLDIIPLEVIVRNIAAGSLLKRLGIPEGLELEQPLVEFIFKPDEVGDPMLNESYAEALGLATEEELERIKELALKVNEVL 164

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1071575469 162 QELFNQMNITLIDFKLEFGRDAAGEILLADEISPDTCRLWDKETNQ----KLDKDVFRRNIGNLTDVYTEV 228
Cdd:TIGR00081 165 KKYFDEKGIILVDFKLEFGLDEEGNLILADEVSPDTCRLWDKETYEvgapKLDKDIFRRTLGKLIEAYETV 235
SAICAR_synt cd00476
5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; SAICAR synthetase ...
 5-233 2.85e-65

5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; SAICAR synthetase (the PurC gene product) catalyzes the seventh step of the de novo biosynthesis of purine nucleotides (also reported as eighth step). It converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.


Pssm-ID: 133468  Cd Length: 230  Bit Score: 201.92  E-value: 2.85e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071575469   5 LVYEGKAKRLFKTEeAGVLRVAYKDDATALNGVRKESFAGKGELNNQITSLIFSHLAEAGIESHFIRAISETEQLVKEVS 84
Cdd:cd00476     1 TLYRGKTKIVYETK-DGVLLLEFKDDISAGDGARRNFLDEKGDITAKLTLFIFKYLSEAGIPTHFVERLGPRTLLVDKLK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071575469  85 IIPLEVVVRNVMAGSLAKRL-GKEEGEPIPNAIVEFYYKDDALDDPFINDDHVLYLEVATTSEMDTIRQAARSINKVLQE 163
Cdd:cd00476    80 *IPLEVVVRNRATGSFVKRYgGFKEGREFPPPLVEFFYKDDAEHDPIVSEDQLERLGFIGKVDVER*KELAVKINTVLKK 159

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1071575469 164 LFNQMNITLIDFKLEFGRDAAGEILLADEISPDTCRLWDKET-NQKLDKDVFRRNIGNLTDVYTEVLNRLK 233
Cdd:cd00476   160 LFSPAGLELWDFKLEFGLDEEGEIVLGDEISPDSSRLWRKGGePYDKDLFRRRASLGQIIEKYEEVAELVR 230
SAICAR_synt_Ade5 cd01416
Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; ...
 3-233 4.85e-47

Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Eukaryotic group of SAICAR synthetases represented by the Drosophila melanogaster, N-terminal, SAICAR synthetase domain of bifunctional Ade5. The Ade5 gene product (CAIR-SAICARs) catalyzes the sixth and seventh steps of the de novo biosynthesis of purine nucleotides (also reported as seventh and eighth steps). SAICAR synthetase converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.


Pssm-ID: 133471  Cd Length: 252  Bit Score: 156.30  E-value: 4.85e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071575469   3 NELVYEGKAKRLFK-TEEAGVLRVAYKDDATALNGVRKESFAGKGELNNQITSLIFSHLAEAGIESHFIRAISETEQLVK 81
Cdd:cd01416     4 GKKLIEGKTKIVYElPDQPGLVLIQSKDRITAGDGARKDEIEGKAAISNKTTSNVFELLQEAGIKTHFVKQCSPTAFIAR 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071575469  82 EVSIIPLEVVVRNVMAGSLAKR-LGKEEGEPIPNAIVEFYYKDDALDDPFINDDHVLYLE------VATTSEMDTIRQAA 154
Cdd:cd01416    84 KCEMIPIEWVCRRIATGSFLKRnPGVKEGYRFSPPKLEFFYKDDANHDPQWSEEQLLEAKlncgglKIGKKEVDIMTKST 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071575469 155 RSINKVLQELFNQMNITLIDFKLEFGRDA-AGEILLADEISPDTCRLWDKE-TNQKLDKDVFRrnigNLTDVYTEVLNRL 232
Cdd:cd01416   164 IAIFEILEKAWATQDCTLVDMKIEFGVDVtTGEILLADVIDNDSWRLWPSGdKRLMKDKQVYR----NLKEVTDEALQEV 239


                  .
gi 1071575469 233 K 233
Cdd:cd01416   240 K 240
SAICAR_synt_Sc cd01414
non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; ...
 44-215 1.59e-26

non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Eukaryotic, bacterial, and archaeal group of SAICAR synthetases represented by the Saccharomyces cerevisiae (Sc) enzyme, mostly absent in metazoans. SAICAR synthetase catalyzes the seventh step of the de novo biosynthesis of purine nucleotides (also reported as eighth step). It converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.


Pssm-ID: 133469 [Multi-domain]  Cd Length: 279  Bit Score: 103.40  E-value: 1.59e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071575469  44 GKGELNNQITSLIFSHLAEaGIESHFIRAISETEQ-------------LVKEVSIIPLEVVVRNVMAGSLAKRL------ 104
Cdd:cd01414    39 GKGEVLTQISAFWFELTED-IIPNHLISTDVEDLPeikepedpdgrsmVVKKAKPIPIECIVRGYLTGSGWKEYqkggtv 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071575469 105 -------GKEEGEPIPNAIVEFYYKDDALDDPFINDDHVLylEVATTSEMDTIRQAARSINKVLQELFNQMNITLIDFKL 177
Cdd:cd01414   118 cgiklpeGLREAQKLPEPIFTPSTKAEEGHDENISFEEAV--EIIGAELADELRELALALYERAAEYAAKRGLILADTKF 195

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1071575469 178 EFGRDAAGEILLADEI-SPDTCRLWDKETNQK------LDKDVFR 215
Cdd:cd01414   196 EFGLDENGEIILIDEVlTPDSSRFWPADSYEPgkeqpsFDKQFVR 240
PRK12607 PRK12607
phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional
 79-215 9.13e-12

phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional


Pssm-ID: 183621 [Multi-domain]  Cd Length: 313  Bit Score: 63.37  E-value: 9.13e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071575469  79 LVKEVSIIPLEVVVRNVMAGSLAK--RLGKEE--GEPIPNAIVEfyykDDALDDPFI-------NDDH--------VLYL 139
Cdd:PRK12607   88 VGKRCEPFPVEMVVRGYLAGSTWRlyKAGKREmyGVTLPDGLRE----NQKLPEPIItpttkaeEGGHdepispeeILAQ 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071575469 140 EVATTSEMDTIRQAARSINKVLQELFNQMNITLIDFKLEFGRDAAGEILLADEI-SPDTCRLWDKETNQK---------- 208
Cdd:PRK12607  164 GLLTPEDWDELSKYALALFARGQEMAAERGLILVDTKYEFGKDADGRIVLIDEIhTPDSSRYWYADGYEErfaagepqeq 243


                  ....*..
gi 1071575469 209 LDKDVFR 215
Cdd:PRK12607  244 LDKEFVR 250
PLN02544 PLN02544
phosphoribosylaminoimidazole-succinocarboxamide synthase
 45-201 4.80e-11

phosphoribosylaminoimidazole-succinocarboxamide synthase


Pssm-ID: 178159 [Multi-domain]  Cd Length: 370  Bit Score: 61.76  E-value: 4.80e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071575469  45 KGELNNQiTSLIFSHLAEAGIESHFIRAISETEQLVKEVSIIPLEVVVRNVMAGSLAKRL------------------GK 106
Cdd:PLN02544  114 KGQVLNQ-TSAWWFNNTKHITPNALVSSPDPNVTIAKKCSVFPVEFVVRGYMTGSTSTSLwtvynkgvrnycgndlpdGM 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071575469 107 EEGEPIPNAIVEFYYKDDALDDPfINDDHVLYLEVATTSEMDTIRQAARSINKVLQELFNQMNITLIDFKLEFGRDAAGE 186
Cdd:PLN02544  193 VKNQKLPANILTPTTKAADHDVP-ISPEEIVEEGLMTQEDFDEVSSKALALFAFGQEVAAEHGLILVDTKYEFGKDADGT 271

                         170
                  ....*....|....*.
gi 1071575469 187 ILLADEI-SPDTCRLW 201
Cdd:PLN02544  272 ILLIDEVhTPDSSRYW 287
PRK13961 PRK13961
phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional
 44-207 6.46e-10

phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional


Pssm-ID: 237571  Cd Length: 296  Bit Score: 57.90  E-value: 6.46e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071575469  44 GKGELNNQITSLIFSHLAEAgIESHFIRA-----ISETEQ--------LVKEVSIIPLEVVVRNVMAGSLAK---RLGKE 107
Cdd:PRK13961   52 DKGRVLTQMSNFWFDKLAHI-VPNHLTGIdvddvVPADEAdqvlgravVVKKLKPLPVECVVRGYLTGSGWKdyqATGTV 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071575469 108 EGEPIPNAIVEfyykDDALDDPF---------------INDDHVLYLEVATTSEmdTIRQAARSINKVLQELFNQMNITL 172
Cdd:PRK13961  131 CGIKLPAGLVE----ASKLPEPIftpatkaelgdhdenISFEEVVELVGAELAA--QLRDATLAIYKEAADYAATRGIII 204

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1071575469 173 IDFKLEFGRDAAGEILLADEI-SPDTCRLWDKETNQ 207
Cdd:PRK13961  205 ADTKFEFGLDEDGTLTLMDEVlTPDSSRFWPADSYQ 240
PRK13959 PRK13959
phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional
 44-215 1.44e-09

phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional


Pssm-ID: 237570  Cd Length: 341  Bit Score: 57.00  E-value: 1.44e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071575469  44 GKGELNNQITSLIFSHLAEAGIESHFIRAISE-------------TEQLVKEVSI------------------------I 86
Cdd:PRK13959   43 DKGASLCTMGAYNFELLEEEGIKTHYIGVVEDgevvrlaeaseppNEMAVKLTQVpdlpfeggsydydayheaagenylI 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071575469  87 PLEVVVRN--VMAGSLAKRLGK----------------EEGEPIPNAIVEFYYKDDAlDDPFINDDHVLYLEVATTSEMD 148
Cdd:PRK13959  123 PLEVIFRNyvPVGSSLRDRIKEgkikpedlgldadewpEEGVKLPEPIVEFSTKYEE-QDRYLSRKEADEIAGLSRAEIE 201

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1071575469 149 TIRQAARSINKVLQELFNQMNITLIDFKLEFGRDAAGEILLADEI-SPDTCRLwdKETNQKLDKDVFR 215
Cdd:PRK13959  202 ELEELALKVDEIITEEAEKRGLIHEDGKIEFALYEEREIRVVDVVgTFDENRF--SYEGQELSKEVVR 267
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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