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Conserved domains on  [gi|1035525374|gb|OAX71646|]
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MarR family transcriptional regulator [Mycobacterium leprae 7935681]

Protein Classification

MarR family transcriptional regulator( domain architecture ID 12204203)

MarR family transcriptional regulator is a winged helix-turn-helix domain-containing protein, named for an Escherichia coli regulator of an operon that encodes a drug efflux pump

Gene Ontology:  GO:0003677|GO:0003700
PubMed:  10498949

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
42-135 4.11e-22

helix_turn_helix multiple antibiotic resistance protein;


:

Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 84.95  E-value: 4.11e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1035525374   42 ITFPQFRTLVILSNRGPVNLATLAGLLGVQPSATGRMVDRLVAARLIDRLPHPTSRRELLVALTKRGREVVRRVTAQRRV 121
Cdd:smart00347   8 LTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQLLEARSE 87

                           90
                   ....*....|....
gi 1035525374  122 EIARIVEKMPPSER 135
Cdd:smart00347  88 TLAELLAGLTAEEQ 101
 
Name Accession Description Interval E-value
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
42-135 4.11e-22

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 84.95  E-value: 4.11e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1035525374   42 ITFPQFRTLVILSNRGPVNLATLAGLLGVQPSATGRMVDRLVAARLIDRLPHPTSRRELLVALTKRGREVVRRVTAQRRV 121
Cdd:smart00347   8 LTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQLLEARSE 87

                           90
                   ....*....|....
gi 1035525374  122 EIARIVEKMPPSER 135
Cdd:smart00347  88 TLAELLAGLTAEEQ 101
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
10-148 9.17e-22

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 85.02  E-value: 9.17e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1035525374  10 DESLDDITDALLTASRLLVAVSAHSIGQVDetITFPQFRTLVILSNRGPVNLATLAGLLGVQPSATGRMVDRLVAARLID 89
Cdd:COG1846     6 DPAEERLGLLLRRLARALRRALDRALAELG--LTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVE 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1035525374  90 RLPHPTSRRELLVALTKRGREVVRRVTAQRRVEIARIVEKMPPSERLGLVRALTAFSTA 148
Cdd:COG1846    84 REPDPEDRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRLAEN 142
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 42-99 8.38e-12

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 57.17  E-value: 8.38e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1035525374  42 ITFPQFRTLVILSNRGPVNLATLAGLLGVQPSATGRMVDRLVAARLIDRLPHPTSRRE 99
Cdd:pfam01047   1 LTLTQFHILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRRE 58
PRK11512 PRK11512
multiple antibiotic resistance transcriptional regulator MarR;
42-108 2.03e-08

multiple antibiotic resistance transcriptional regulator MarR;


Pssm-ID: 183170  Cd Length: 144  Bit Score: 50.28  E-value: 2.03e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1035525374  42 ITFPQFRTLVILSNRGPVNLATLAGLLGVQPSATGRMVDRLVAARLIDRLPHPTSRRELLVALTKRG 108
Cdd:PRK11512   38 ITAAQFKVLCSIRCAACITPVELKKVLSVDLGALTRMLDRLVCKGWVERLPNPNDKRGVLVKLTTSG 104
 
Name Accession Description Interval E-value
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
42-135 4.11e-22

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 84.95  E-value: 4.11e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1035525374   42 ITFPQFRTLVILSNRGPVNLATLAGLLGVQPSATGRMVDRLVAARLIDRLPHPTSRRELLVALTKRGREVVRRVTAQRRV 121
Cdd:smart00347   8 LTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQLLEARSE 87

                           90
                   ....*....|....
gi 1035525374  122 EIARIVEKMPPSER 135
Cdd:smart00347  88 TLAELLAGLTAEEQ 101
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
10-148 9.17e-22

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 85.02  E-value: 9.17e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1035525374  10 DESLDDITDALLTASRLLVAVSAHSIGQVDetITFPQFRTLVILSNRGPVNLATLAGLLGVQPSATGRMVDRLVAARLID 89
Cdd:COG1846     6 DPAEERLGLLLRRLARALRRALDRALAELG--LTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVE 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1035525374  90 RLPHPTSRRELLVALTKRGREVVRRVTAQRRVEIARIVEKMPPSERLGLVRALTAFSTA 148
Cdd:COG1846    84 REPDPEDRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRLAEN 142
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 42-99 8.38e-12

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 57.17  E-value: 8.38e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1035525374  42 ITFPQFRTLVILSNRGPVNLATLAGLLGVQPSATGRMVDRLVAARLIDRLPHPTSRRE 99
Cdd:pfam01047   1 LTLTQFHILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRRE 58
PRK11512 PRK11512
multiple antibiotic resistance transcriptional regulator MarR;
42-108 2.03e-08

multiple antibiotic resistance transcriptional regulator MarR;


Pssm-ID: 183170  Cd Length: 144  Bit Score: 50.28  E-value: 2.03e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1035525374  42 ITFPQFRTLVILSNRGPVNLATLAGLLGVQPSATGRMVDRLVAARLIDRLPHPTSRRELLVALTKRG 108
Cdd:PRK11512   38 ITAAQFKVLCSIRCAACITPVELKKVLSVDLGALTRMLDRLVCKGWVERLPNPNDKRGVLVKLTTSG 104
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 42-99 1.40e-06

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 43.35  E-value: 1.40e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1035525374  42 ITFPQFRTLVILSNRGPVNLATLAGLLGVQPSATGRMVDRLVAARLIDRLPHPTSRRE 99
Cdd:pfam12802   3 LTPAQFRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRRA 60
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
55-121 1.13e-03

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 37.11  E-value: 1.13e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1035525374  55 NRGPVNLATLAGLLGVQPSATGRMVDRLVAARLIDRLPhptsRREllVALTKRGREVVRRVTAQRRV 121
Cdd:COG1321    21 EGGPVRTSDIAERLGVSPPSVTEMLKKLEEKGLVEYEP----YGG--ITLTEEGRELALRIVRRHRL 81
HTH_27 pfam13463
Winged helix DNA-binding domain;
56-108 9.68e-03

Winged helix DNA-binding domain;


Pssm-ID: 433228 [Multi-domain]  Cd Length: 68  Bit Score: 33.03  E-value: 9.68e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1035525374  56 RGPVNLATLAGLLGVQPSATGRMVDRLVAARLIDRLPHPTSRRELLVALTKRG 108
Cdd:pfam13463  16 GDPKTLADICFRLNVEDSHVSYSLKKLTEAGLVEREGSEEDGRETRVRLTAKG 68
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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