BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032292354 146 DCSTVVRVKELHISSPILAAKSPFFYKLFSNGMRESEQRHVTLRINASEeaALMELLNFMYSNAVSVTTApALLDVLMAA 225
Cdd:cd18186     3 DVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSSSEIELDDVSPE--AFEALLDYIYTGELELSEE-NVEELLAAA 79

                  ...
gi 1032292354 226 DKF 228
Cdd:cd18186    80 DKL 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032292354 146 DCSTVVRVKELHISSPILAAKSPFFYKLFSNGMRESEQRHVTLRINASEeaALMELLNFMYSNAVSVTTApALLDVLMAA 225
Cdd:cd18186     3 DVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSSSEIELDDVSPE--AFEALLDYIYTGELELSEE-NVEELLAAA 79

                  ...
gi 1032292354 226 DKF 228
Cdd:cd18186    80 DKL 82

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032292354 146 DCSTVVRVKELHISSPILAAKSPFFYKLFSNGMRESEQRHVTLR-INASeeaALMELLNFMYSNAVSvtTAPALLDVLMA 224
Cdd:pfam00651  12 DVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDdVSPE---DFEALLEFMYTGKLI--SEENVDDLLAA 86

                          90
                  ....*....|....*....
gi 1032292354 225 ADKFEVASCMRYCSRLLRN 243
Cdd:pfam00651  87 ADKLQIPSLVDKCEEFLIK 105

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032292354 270 LTDAAKQFLAARYKDITKfHEEVMSLPLAGIEAILSSDELQIASEDAVYDFILKWARAQypcLEERREILGSRLALsIRF 349
Cdd:pfam07707  16 LAEAALRFILQNFLEVAK-SEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHD---VERRKKHLPELLSA-VRL 90

                  ....
gi 1032292354 350 PFMT 353
Cdd:pfam07707  91 PLLS 94

kelch-like protein; Provisional

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032292354 162 ILAAKSPFFYKLFSNGMRESEqrhVTLRINaseEAALMELLNFMYSNAVSVTTApALLDVLMAADKFEVASCMRYCSR-L 240
Cdd:PHA03098   29 ILSSSSEYFKKMFKNNFKENE---INLNID---YDSFNEVIKYIYTGKINITSN-NVKDILSIANYLIIDFLINLCINyI 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032292354 241 LRNMpmTPESALLYLELPSSVLMAKavqpLTDAAKQFLAARYKDITKFhEEVMSLPLAGIEAILSSDELQIASEDAVYDF 320
Cdd:PHA03098  102 IKII--DDNNCIDIYRFSFFYGCKK----LYSAAYNYIRNNIELIYND-PDFIYLSKNELIKILSDDKLNVSSEDVVLEI 174

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1032292354 321 ILKWARA-QYPCLEERREILGsrlalSIRFPFMTCRKLKK 359
Cdd:PHA03098  175 IIKWLTSkKNNKYKDICLILK-----VLRITFLSEEGIKK 209

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032292354 146 DCSTVVRVKELHISSPILAAKSPFFYKLFSNGMRESEQRHVTLRINASEeaALMELLNFMYSNAVSVTTApALLDVLMAA 225
Cdd:cd18186     3 DVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSSSEIELDDVSPE--AFEALLDYIYTGELELSEE-NVEELLAAA 79

                  ...
gi 1032292354 226 DKF 228
Cdd:cd18186    80 DKL 82

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032292354 146 DCSTVVRVKELHISSPILAAKSPFFYKLFSNGMRESEQRHVTLR-INASeeaALMELLNFMYSNAVSvtTAPALLDVLMA 224
Cdd:pfam00651  12 DVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDdVSPE---DFEALLEFMYTGKLI--SEENVDDLLAA 86

                          90
                  ....*....|....*....
gi 1032292354 225 ADKFEVASCMRYCSRLLRN 243
Cdd:pfam00651  87 ADKLQIPSLVDKCEEFLIK 105

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032292354 150 VVRVKELHISSPILAAKSPFFYKLFSNGMRESEQRHVTLRInaSEEAALMELLNFMYSNAVsVTTAPALLDVLMAADKFE 229
Cdd:cd18314    12 CVGDRKFFAHRIVLCARSPVFRSMLTGSMIESNLKEVTLED--VEPEIFETVLKYMYTGQV-TLSEENVLDLLMLASKYQ 88

                  .
gi 1032292354 230 V 230
Cdd:cd18314    89 V 89

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032292354 268 QPLTDAAKQFLAARYKDITKfHEEVMSLPLAGIEAILSSDELQIASEDAVYDFILKWARAQypclEERREILGSRLALSI 347
Cdd:cd18457    19 SSLVDAANKYIQQHFIEVSK-SEEFLALSKEEVLEILSRDELNVKSEEQVFEAALAWVKYD----RENREEYLPELLSKV 93

                  ....*.
gi 1032292354 348 RFPFMT 353
Cdd:cd18457    94 RLPLLR 99

kelch-like protein; Provisional

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032292354 162 ILAAKSPFFYKLFSNGMRESEqrhVTLRINaseEAALMELLNFMYSNAVSVTTApALLDVLMAADKFEVASCMRYCSR-L 240
Cdd:PHA03098   29 ILSSSSEYFKKMFKNNFKENE---INLNID---YDSFNEVIKYIYTGKINITSN-NVKDILSIANYLIIDFLINLCINyI 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032292354 241 LRNMpmTPESALLYLELPSSVLMAKavqpLTDAAKQFLAARYKDITKFhEEVMSLPLAGIEAILSSDELQIASEDAVYDF 320
Cdd:PHA03098  102 IKII--DDNNCIDIYRFSFFYGCKK----LYSAAYNYIRNNIELIYND-PDFIYLSKNELIKILSDDKLNVSSEDVVLEI 174

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1032292354 321 ILKWARA-QYPCLEERREILGsrlalSIRFPFMTCRKLKK 359
Cdd:PHA03098  175 IIKWLTSkKNNKYKDICLILK-----VLRITFLSEEGIKK 209

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032292354 147 CSTVVRV--KELHISSPILAAKSPFFYKLFSNGMRESEQRHVTLrinASEEAALMEL-LNFMYSNAVSVtTAPALLDVLM 223
Cdd:cd18240    18 CDVVIRVngVEFPAHRNILCACSPYFRALFTNGWNETEKKVYKI---PGVSPEMMELiIEYAYTRTVPI-TAENVEELLP 93

                          90
                  ....*....|....*....
gi 1032292354 224 AADKFEVASCMRYCSRLLR 242
Cdd:cd18240    94 AADQFNIMGIVKACCDFLE 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032292354 162 ILAAKSPFFYKLFSNGMRESEQRHVTLR-INASeeaALMELLNFMYSNAVSVTTApALLDVLMAADKFEVASCMRYCSRL 240
Cdd:cd18247    37 VLAATIPYFHAMFTHDMVESKQDEITMQgIEPS---ALEALINFAYSGRIAIDTS-NVQSLLVGASFLQLQSVKDACCEF 112

                  ...
gi 1032292354 241 LRN 243
Cdd:cd18247   113 LKE 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032292354 162 ILAAKSPFFYKLFSNGMRESEQRHVtlRINASEEAALMELLNFMYSNAVSVTTAPAlLDVLMAADKFEVASCMRYCSRLL 241
Cdd:cd18256    38 VLAASSPYFAALFAGGMSESSKDVV--QIHGVEPDIFHILLDFIYTGVVEVTVSNV-QELLVAADMLQLTEVVEICCEFL 114

                  .
gi 1032292354 242 R 242
Cdd:cd18256   115 K 115

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also termed Kelch repeat and BTB domain-containing protein 9 (KBTBD9), belongs to the KLHL family. Its function remains unclear. A nuclear receptor subfamily 5, group A, member 2 (NR5A2)-Kelch-like family member 29 (KLHL29) fusion transcript may participate in the origin or progression of some colon cancers.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032292354 258 PSSVL----MAKAVQ--PLTDAAKQFLAARYKDITKfHEEVMSLPLAGIEAILSSDELQIASEDAVYDFILKWARAQYPC 331
Cdd:cd18468     2 PSNCLgiwaLAEALQctELHNMAKAYALQNFPDVAR-QEEILSISKDDIVEYLSHDSLNTKAEELVFETAIKWLKKDPKN 80

                          90       100
                  ....*....|....*....|..
gi 1032292354 332 leeRREILGSRLAlSIRFPFMT 353
Cdd:cd18468    81 ---RKQHIAELLA-VVRLPFIH 98

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032292354 162 ILAAKSPFFYKLFSNGMRESEQRHVtlRINASEEAALMELLNFMYSNAVSVTTApALLDVLMAADKFEVASCMRYCSRLL 241
Cdd:cd18274    41 VLAAISPYFRSMFTSGLTESTQKEV--RIVGVEAESMHLVLDYAYTSRVTLTEA-NVQALFTAASIFQIPSLQDQCAQFM 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032292354 142 NWGMDCSTVVRV--KELHISSPILAAKSPFFYKLFSNGMRESEQRhvTLRINASEEAALMELLNFMYSNAVSVTTApALL 219
Cdd:cd18326    21 TQGLLCDVVILVegREFPTHRSVLAACSQYFKKLFTSGAVVDQQN--VYEIDFVSAEALTALLDFAYTATLTVSTS-NVG 97

                          90       100
                  ....*....|....*....|..
gi 1032292354 220 DVLMAADKFEVASCMRYCSRLL 241
Cdd:cd18326    98 DILSAARLLEIPAVSHVCADLL 119

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032292354 142 NWGMDCSTVVRVKELHISSPILAAKSPFFYKLFSNGMRESEQRHVTLRINASEeaALMELLNFMYSNAVSVTTAPALLDV 221
Cdd:cd18286    15 GEDSDITIKVDGKTFKAHRCILCARSSYFAAMLSGSWAESNSSEITLTGVSHA--AVSFVLLFIYGGVLDLPDDVNLGEL 92

                  ....*
gi 1032292354 222 LMAAD 226
Cdd:cd18286    93 LSLAD 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032292354 162 ILAAKSPFFYKLFSNGMRESEQRHVTLriNASEEAALMELLNFMYSNAVSVtTAPALLDVLMAADKFEVASCMRYCSR-L 240
Cdd:cd18306    36 VLACASPYLFELFSSDSDGESILTVKL--DGLDPDAVEVLVNYAYTSRLEV-PADLVKSVYSAAKKLKMDRVKKACGDfL 112

                          90
                  ....*....|..
gi 1032292354 241 LRNmpMTPESAL 252
Cdd:cd18306   113 LEK--LTPQNCI 122

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032292354 154 KELHISSPILAAKSPFFYKLFSNGMRESEQRHVTLRinASEEAALMELLNFMYSNAVSVT 213
Cdd:cd18235    31 VEIPAHRVVLASCSPYFHAMFTGDLSESRANRVTLQ--DVDGKALLLLIDYVYTAEIQVT 88

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032292354 146 DCSTVVRVKELHISSPILAAKSPFFYKLFSNGMRESEQRHVtlRINASEEAALMELLNFMYS-NAVSVTTAPALLDVLMA 224
Cdd:cd18344    25 DCCLLVAGHEFRAHKAILAARSPVFRAMFEHEMEERLKNPI--EIHDLDPQVFKEMMGFIYTgKAPHLHSHSMACDVLAA 102

                          90       100
                  ....*....|....*....|.
gi 1032292354 225 ADKFEVASCMRYCSRLL-RNM 244
Cdd:cd18344   103 ADKYGLEGLKVLCEDALcRNL 123

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032292354 156 LHISSPILAAKSPFFYKLFSNGMRESEQRHVTL-RINASEeaaLMELLNFMYSNAVSVTTaPALLDVLMAADKFEVASCM 234
Cdd:cd18263    25 FRVHRVILAAGSDYFRAMFTSGMKESTQSVVQLpTIPAKD---LRLLISFAYSGILHLSW-ENLFEATCTALQLQISGAL 100

                          90
                  ....*....|....*...
gi 1032292354 235 RYCSRLLRNmPMTPESAL 252
Cdd:cd18263   101 ALCLDFLQR-EISPARCL 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1032292354 144 GMDCSTVVRV--KELHISSPILAAKSPFFYKLFSNGMRESEQRHVTLriNASEEAALMELLNFMYSNAVSV 212
Cdd:cd18246    37 GLLCDIVLHVgtKEIKAHKVVLASCSPYFHAMFTNEMSESRQTHVTL--HDIDPQALEQLVQYAYTAEIVV 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032292354 145 MDCSTVVRVKELHISSPILAAKSPFFYKLFSNGMRESEQRHVTLRinASEEAALMELLNFMYSNAVSVTTApALLDVLMA 224
Cdd:cd18340    28 VDCVLKIKEKEFPCHRLVLAACSPYFRAMFLSDLEESKKREIVLE--DVDPDVMGKILHYIYTSEIEITEQ-NVQDIFAA 104

                          90
                  ....*....|....*...
gi 1032292354 225 ADKFEVASCMRYCSRLLR 242
Cdd:cd18340   105 ANMFQIPSIFTVCVSFLQ 122

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032292354 270 LTDAAKQFLAARYKDITKfHEEVMSLPLAGIEAILSSDELQIASEDAVYDFILKWARAQYpclEERREILGSRLAlSIRF 349
Cdd:cd18477    21 LAVSARDFICAHFTLVAK-DEDFLGLSADELIAIISSDGLNVEKEEAVFEAVMKWVREAK---ENRQKALPTVFE-SIRF 95

                  ....
gi 1032292354 350 PFMT 353
Cdd:cd18477    96 RLLP 99

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. It is abundantly expressed in ovary, adrenal gland, and thymus.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032292354 264 AKAVQPLTDAAKQFLAARYKDITKfHEEVMSLPLAGIEAILSSDELQIASEDAVYDFILKWARAQypcLEERREILgSRL 343
Cdd:cd18511    16 AQGCTDLHKVAHNYTMEHFMEVIR-NQEFLLLPASEIAKLLASDDMNIPNEETILNALLSWVRHD---VEQRRKDL-SKL 90

                  ....*....
gi 1032292354 344 ALSIRFPFM 352
Cdd:cd18511    91 LAYIRLPLL 99

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032292354 144 GMDCSTVVRVK------ELHISSPILAAKSPFFYKLFSNGMRESEQRHVTLRinASEEAALMELLNFMYSNAVSVTTApA 217
Cdd:cd18248    19 QQLCDVTLKVKyqdpkeEFMAHKVVLASSSPYFKAMFTSGLRECGMEVVPIE--GVHPCVMSRLIEFAYTASISVGEK-C 95

                          90       100
                  ....*....|....*....|....
gi 1032292354 218 LLDVLMAADKFEVASCMRYCSRLL 241
Cdd:cd18248    96 VLHVLPGAVMYQMDSVVKACCDFL 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032292354 154 KELHISSPILAAKSPFFYKLFSNGMRESEQRHVTLRINASEeaALMELLNFMYSNAVSVTTApALLDVLMAADKFEVASC 233
Cdd:cd18268    33 KEIPCHRNVLASSSPYFRAMFCNNFRESSQAKVDLKGIDSD--VLDQIVDYVYTGEILITRD-NVLPLMEAASMLQYPKL 109

                          90
                  ....*....|....*....
gi 1032292354 234 MRYCSRLLRNMpMTPESAL 252
Cdd:cd18268   110 FEACSLYLQDQ-LTPENCL 127

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1032292354 289 HEEVMSLPLAGIEAILSSDELQIASEDAVYDFILKWARAQypclEERREILGSRLALSIRFPFM 352
Cdd:cd18446    39 HEEFLELPVDILCHILKSDDLYVTEEEQVFETVMRWVRYK----ESERLPLLPRVLENVRLPLL 98

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032292354 146 DCSTVVRVKELHISSPILAAKSPFFYKLFSNGMRESEQRHVTLRINASEEAALMELLNFMYSNAVSVTTApALLDVLMAA 225
Cdd:cd18245    16 DATLVVGGEEIPVQKNVLAAASPYFRAKLNYNPPKDDGSTYKIELEGISVEVMEEILDYIYTGQIKLSED-NIQDIVQAA 94

                  .
gi 1032292354 226 D 226
Cdd:cd18245    95 D 95

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1032292354 162 ILAAKSPFFYKLFSNGMRESEQRHVTLRINASEEaALMELLNFMYSNAVSVT--TAPALLD 220
Cdd:cd18254    40 VLAACSRYFEAMFSNGLRESLDSTVNFHDSLHPE-VLELLLDFAYSSRIIINeeNAESLLE 99

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1032292354 246 MTPESALLYLELPSSVLMAKavqpLTDAAKQFLAARYKDITKFHEEVMSLPLAGIEAILSSDELQIASEDAVYDFILKW 324
Cdd:cd18450     1 LTPENCIGIRKFARYYFCPE----LERKAYRYILRNFEEVAKDSEEFLELSCEELEDIIEDDELNVKEEEVVFEAIVKW 75

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This subfamily includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. Both KLHL2 and KLHL3 function as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1032292354 289 HEEVMSLPLAGIEAILSSDELQIASEDAVYDFILKWARAQYpclEERREILgSRLALSIRFPFMT 353
Cdd:cd18445    39 GEEFLLLSKEQVCELISSDDLTVPSEEKVFEAVMSWVNHDP---ENRKEHL-AELLEHVRLPLLS 99