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Conserved domains on  [gi|1032286088|gb|OAP00416|]
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hypothetical protein AXX17_AT4G44940 [Arabidopsis thaliana]

Protein Classification

F-box/kelch-repeat protein( domain architecture ID 17778853)

F-box/kelch-repeat protein may be a component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins

CATH:  1.20.1280.50|2.120.10.80
Gene Ontology:  GO:0006511|GO:0019005|GO:0005515|GO:0016567
PubMed:  10603472|31898225|11178263|31442578|24959344|10581972
SCOP:  4001927|3000448

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NanM super family cl34543
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
118-252 1.65e-15

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


The actual alignment was detected with superfamily member COG3055:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 74.42  E-value: 1.65e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032286088 118 PVHCSGLVAVGSDIYNIGGSIINEHSSSVS----ILDCRYHTWRDAPNMLVERNSHAANVIDGKIYVAGGSRDSNSSNWM 193
Cdd:COG3055    60 PRHHAAAVAQDGKLYVFGGFTGANPSSTPLndvyVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWV 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032286088 194 EVFDIKTQTWE---PVLNP---------------IADGCD-----------------RRIRKSAVIEEAICLFGYKGvGV 238
Cdd:COG3055   140 EVYDPATGTWTqlaPLPTPrdhlaaavlpdgkilVIGGRNgsgfsntwttlaplptaRAGHAAAVLGGKILVFGGES-GF 218

                         170
                  ....*....|....*....
gi 1032286088 239 -----AYNPRIDKWEAIGE 252
Cdd:COG3055   219 sdeveAYDPATNTWTALGE 237
F-box_AtAFR-like cd22152
F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and ...
 27-70 1.26e-13

F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and similar proteins; AtAFR, also called SKP1-interacting partner 29 (AtSKIP29), or F-box protein AFR, is a component of SCF (SKP1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It is part of the phyA-mediated signaling transduction pathway leading to the regulation of gene expression and hypocotyl elongation in response to red and far-red light exposure. This subfamily also includes many other Arabidopsis thaliana SKP1-interacting partner proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438923  Cd Length: 45  Bit Score: 63.36  E-value: 1.26e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1032286088  27 ILSLPVDLLISILARVSRLDYPILSLVSKSFRSLIASPELYETR 70
Cdd:cd22152     2 IPGLPDDIALQCLARVPRSSHPSLSLVSKSWRSLLSSPELFRVR 45
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
118-252 1.65e-15

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 74.42  E-value: 1.65e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032286088 118 PVHCSGLVAVGSDIYNIGGSIINEHSSSVS----ILDCRYHTWRDAPNMLVERNSHAANVIDGKIYVAGGSRDSNSSNWM 193
Cdd:COG3055    60 PRHHAAAVAQDGKLYVFGGFTGANPSSTPLndvyVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWV 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032286088 194 EVFDIKTQTWE---PVLNP---------------IADGCD-----------------RRIRKSAVIEEAICLFGYKGvGV 238
Cdd:COG3055   140 EVYDPATGTWTqlaPLPTPrdhlaaavlpdgkilVIGGRNgsgfsntwttlaplptaRAGHAAAVLGGKILVFGGES-GF 218

                         170
                  ....*....|....*....
gi 1032286088 239 -----AYNPRIDKWEAIGE 252
Cdd:COG3055   219 sdeveAYDPATNTWTALGE 237
F-box_AtAFR-like cd22152
F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and ...
 27-70 1.26e-13

F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and similar proteins; AtAFR, also called SKP1-interacting partner 29 (AtSKIP29), or F-box protein AFR, is a component of SCF (SKP1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It is part of the phyA-mediated signaling transduction pathway leading to the regulation of gene expression and hypocotyl elongation in response to red and far-red light exposure. This subfamily also includes many other Arabidopsis thaliana SKP1-interacting partner proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438923  Cd Length: 45  Bit Score: 63.36  E-value: 1.26e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1032286088  27 ILSLPVDLLISILARVSRLDYPILSLVSKSFRSLIASPELYETR 70
Cdd:cd22152     2 IPGLPDDIALQCLARVPRSSHPSLSLVSKSWRSLLSSPELFRVR 45
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 166-206 3.21e-10

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 54.16  E-value: 3.21e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1032286088 166 RNSHAANVIDGKIYVAGGSRDSNSSNWMEVFDIKTQTWEPV 206
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKL 42
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 27-69 1.52e-08

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 49.46  E-value: 1.52e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1032286088  27 ILSLPVDLLISILARVSRLDYPILSLVSKSFRSLIASPELYET 69
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWKK 43
PHA03098 PHA03098
kelch-like protein; Provisional
 111-247 9.04e-08

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 52.46  E-value: 9.04e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032286088 111 ISIPN-SRPVHCSGLVAVGSDIYNIGGSIINEHSSSVSILDCRYHTWRDAPNMLVERNSHAANVIDGKIYVAGG-SRDSN 188
Cdd:PHA03098  324 NKVPElIYPRKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGGiSKNDE 403

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1032286088 189 SSNWMEVFDIKTQTW---EPVLNPIADGC----DRRIRKSAVIEEAICLFGYKGVgVAYNPRIDKW 247
Cdd:PHA03098  404 LLKTVECFSLNTNKWskgSPLPISHYGGCaiyhDGKIYVIGGISYIDNIKVYNIV-ESYNPVTNKW 468
FBOX smart00256
A Receptor for Ubiquitination Targets;
30-70 1.15e-05

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 41.65  E-value: 1.15e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1032286088   30 LPVDLLISILARVSRLDYPILSLVSKSFRSLIASPELYETR 70
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
Kelch smart00612
Kelch domain;
131-176 1.38e-05

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 41.39  E-value: 1.38e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1032286088  131 IYNIGGSIINEHSSSVSILDCRYHTWRDAPNMLVERNSHAANVIDG 176
Cdd:smart00612   2 IYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
118-252 1.65e-15

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 74.42  E-value: 1.65e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032286088 118 PVHCSGLVAVGSDIYNIGGSIINEHSSSVS----ILDCRYHTWRDAPNMLVERNSHAANVIDGKIYVAGGSRDSNSSNWM 193
Cdd:COG3055    60 PRHHAAAVAQDGKLYVFGGFTGANPSSTPLndvyVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWV 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032286088 194 EVFDIKTQTWE---PVLNP---------------IADGCD-----------------RRIRKSAVIEEAICLFGYKGvGV 238
Cdd:COG3055   140 EVYDPATGTWTqlaPLPTPrdhlaaavlpdgkilVIGGRNgsgfsntwttlaplptaRAGHAAAVLGGKILVFGGES-GF 218

                         170
                  ....*....|....*....
gi 1032286088 239 -----AYNPRIDKWEAIGE 252
Cdd:COG3055   219 sdeveAYDPATNTWTALGE 237
F-box_AtAFR-like cd22152
F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and ...
 27-70 1.26e-13

F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and similar proteins; AtAFR, also called SKP1-interacting partner 29 (AtSKIP29), or F-box protein AFR, is a component of SCF (SKP1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It is part of the phyA-mediated signaling transduction pathway leading to the regulation of gene expression and hypocotyl elongation in response to red and far-red light exposure. This subfamily also includes many other Arabidopsis thaliana SKP1-interacting partner proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438923  Cd Length: 45  Bit Score: 63.36  E-value: 1.26e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1032286088  27 ILSLPVDLLISILARVSRLDYPILSLVSKSFRSLIASPELYETR 70
Cdd:cd22152     2 IPGLPDDIALQCLARVPRSSHPSLSLVSKSWRSLLSSPELFRVR 45
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
118-253 1.31e-10

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 60.17  E-value: 1.31e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032286088 118 PVHCSGLVAVGSDIYNIGGSIINEHSSSVSILDCRYHTWRDAPNM-LVERNSHAANVIDGKIYVAGGSRDSNSSNWM--- 193
Cdd:COG3055    12 PRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLpGPPRHHAAAVAQDGKLYVFGGFTGANPSSTPlnd 91

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1032286088 194 -EVFDIKTQTWEPVLN-PIAdgcdRRIRKSAVIEEAICLF-GYKGVGV-----AYNPRIDKWEAIGEV 253
Cdd:COG3055    92 vYVYDPATNTWTKLAPmPTP----RGGATALLLDGKIYVVgGWDDGGNvawveVYDPATGTWTQLAPL 155
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
155-206 1.57e-10

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 60.17  E-value: 1.57e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1032286088 155 TWRDAPNMLVERNSHAANVIDGKIYVAGGSRDSNSSNWMEVFDIKTQTWEPV 206
Cdd:COG3055     2 TWSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSEL 53
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 166-206 3.21e-10

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 54.16  E-value: 3.21e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1032286088 166 RNSHAANVIDGKIYVAGGSRDSNSSNWMEVFDIKTQTWEPV 206
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKL 42
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 27-69 1.52e-08

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 49.46  E-value: 1.52e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1032286088  27 ILSLPVDLLISILARVSRLDYPILSLVSKSFRSLIASPELYET 69
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWKK 43
PHA03098 PHA03098
kelch-like protein; Provisional
 111-247 9.04e-08

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 52.46  E-value: 9.04e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032286088 111 ISIPN-SRPVHCSGLVAVGSDIYNIGGSIINEHSSSVSILDCRYHTWRDAPNMLVERNSHAANVIDGKIYVAGG-SRDSN 188
Cdd:PHA03098  324 NKVPElIYPRKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGGiSKNDE 403

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1032286088 189 SSNWMEVFDIKTQTW---EPVLNPIADGC----DRRIRKSAVIEEAICLFGYKGVgVAYNPRIDKW 247
Cdd:PHA03098  404 LLKTVECFSLNTNKWskgSPLPISHYGGCaiyhDGKIYVIGGISYIDNIKVYNIV-ESYNPVTNKW 468
PHA03098 PHA03098
kelch-like protein; Provisional
 112-214 2.31e-07

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 51.31  E-value: 2.31e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032286088 112 SIPNSRPVHCSGLVAVGSDIYNIGGSIINEHSS-SVSILDCRYHTWRDAPNMLVERNSHAANVIDGKIYVAGGSRDSNSS 190
Cdd:PHA03098  278 TIIDIHYVYCFGSVVLNNVIYFIGGMNKNNLSVnSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISL 357

                          90       100
                  ....*....|....*....|....*..
gi 1032286088 191 NWMEVFDIKTQTWE---PVLNPIADGC 214
Cdd:PHA03098  358 NTVESWKPGESKWReepPLIFPRYNPC 384
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
88-197 1.37e-06

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 48.23  E-value: 1.37e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032286088  88 SDFNPRWFTLCRKPKPSGHVMAAisipnsrpvhcsglvAVGSDIYNIGGSiiNEHSSSVSILDCRYHTWRDAPNMLVERN 167
Cdd:COG3055   181 SGFSNTWTTLAPLPTARAGHAAA---------------VLGGKILVFGGE--SGFSDEVEAYDPATNTWTALGELPTPRH 243

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1032286088 168 SHAANVIDGKIYVAGGS----RDSNSSNWMEVFD 197
Cdd:COG3055   244 GHAAVLTDGKVYVIGGEtkpgVRTPLVTSAEVYD 277
PHA03098 PHA03098
kelch-like protein; Provisional
 130-210 4.53e-06

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 47.45  E-value: 4.53e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032286088 130 DIYNIGG-SIIN--EHSSSVSILDCRYHTWRDAPNMLVERNSHAANVIDGKIYVAGGSRDSNSSNWMEVFDIKTQTWEPV 206
Cdd:PHA03098  439 KIYVIGGiSYIDniKVYNIVESYNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGGDKYEYYINEIEVYDDKTNTWTLF 518


                  ....
gi 1032286088 207 LNPI 210
Cdd:PHA03098  519 CKFP 522
F-box_ScMDM30-like cd22143
F-box domain found in Saccharomyces cerevisiae mitochondrial distribution and morphology ...
 27-67 9.42e-06

F-box domain found in Saccharomyces cerevisiae mitochondrial distribution and morphology protein 30 (ScMDM30) and similar proteins; ScMDM30 is an F-box protein required for maintenance of fusion-competent mitochondria in yeast. It is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. ScMDM30 recognizes FZO1 and regulates the amount of FZO1. It acts as a regulatory factor for the mitochondrial fusion machinery and is required for mitochondrial DNA maintenance. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438915  Cd Length: 44  Bit Score: 41.83  E-value: 9.42e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1032286088  27 ILSLPVDLLISILARVSRLDYPILSLVSKSFRSlIASPELY 67
Cdd:cd22143     2 FDSLPDEILSIIFSHLPQSDLYNLLFVNKHFYS-LALPELW 41
FBOX smart00256
A Receptor for Ubiquitination Targets;
30-70 1.15e-05

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 41.65  E-value: 1.15e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1032286088   30 LPVDLLISILARVSRLDYPILSLVSKSFRSLIASPELYETR 70
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
Kelch smart00612
Kelch domain;
131-176 1.38e-05

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 41.39  E-value: 1.38e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1032286088  131 IYNIGGSIINEHSSSVSILDCRYHTWRDAPNMLVERNSHAANVIDG 176
Cdd:smart00612   2 IYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 118-162 4.50e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 39.90  E-value: 4.50e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1032286088 118 PVHCSGLVAVGSDIYNIGGSIINEHSSSVSILDCRYHTWRDAPNM 162
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSM 45
PLN02193 PLN02193
nitrile-specifier protein
 81-261 5.99e-05

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 43.79  E-value: 5.99e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032286088  81 YLCLGIPSDFNPRWFTLCRKPKPSGhvmaaisipnsrpVHCS-GLVAVGSDIYNIGGSI-----INEHsssVSILDCRYH 154
Cdd:PLN02193  140 YISLPSTPKLLGKWIKVEQKGEGPG-------------LRCShGIAQVGNKIYSFGGEFtpnqpIDKH---LYVFDLETR 203

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032286088 155 TWRDAPNMLVERNSHAANV----IDGKIYVAGGSRDSNSSNWMEVFDIKTQTWEpVLNPIADG-CDRRIRKSAVIEEAIC 229
Cdd:PLN02193  204 TWSISPATGDVPHLSCLGVrmvsIGSTLYVFGGRDASRQYNGFYSFDTTTNEWK-LLTPVEEGpTPRSFHSMAADEENVY 282

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1032286088 230 LFGykgvGVAYNPRIDKWEAigeVNYLDLGWV 261
Cdd:PLN02193  283 VFG----GVSATARLKTLDS---YNIVDKKWF 307
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 27-67 8.87e-05

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 39.00  E-value: 8.87e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1032286088  27 ILSLPVDLLISILARVSRLDYPILSLVSKSFRSLIASPELY 67
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDPKDLLRLALVCRRWRELASDDSLW 41
Kelch_6 pfam13964
Kelch motif;
166-206 1.00e-04

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 39.24  E-value: 1.00e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1032286088 166 RNSHAANVIDGKIYVAGG-SRDSNSSNWMEVFDIKTQTWEPV 206
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGyTNASPALNKLEVYNPLTKSWEEL 43
Kelch_4 pfam13418
Galactose oxidase, central domain;
166-206 1.82e-04

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 38.36  E-value: 1.82e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1032286088 166 RNSHAANVI-DGKIYVAGG-SRDSNSSNWMEVFDIKTQTWEPV 206
Cdd:pfam13418   2 RAYHTSTSIpDDTIYLFGGeGEDGTLLSDLWVFDLSTNEWTRL 44
Kelch smart00612
Kelch domain;
177-206 5.84e-04

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 36.77  E-value: 5.84e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1032286088  177 KIYVAGGSRDSNSSNWMEVFDIKTQTWEPV 206
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPL 30
PRK14131 PRK14131
N-acetylneuraminate epimerase;
164-204 2.26e-03

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 38.84  E-value: 2.26e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1032286088 164 VERNSHAANVIDGKIYVAGGSRDSNSSNWMEVF------DIKTQTWE 204
Cdd:PRK14131   73 GPREQAVAAFIDGKLYVFGGIGKTNSEGSPQVFddvykyDPKTNSWQ 119
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 166-206 2.46e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 35.00  E-value: 2.46e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1032286088 166 RNSHAANVIDGKIYVAGGSRDSN--SSNWMEVFDIKTQTWEPV 206
Cdd:pfam07646   2 RYPHASSVPGGKLYVVGGSDGLGdlSSSDVLVYDPETNVWTEV 44
F-box_AtFBW1-like cd22157
F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) ...
 29-65 3.43e-03

F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) and similar proteins; AtFBW1, also called WD-40-associated F-box protein 1, is an F-box protein that contains four WD-40 repeats, which are separated from each other by a spacer region. Like other F-box proteins, AtFBW1 may be a component of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. This subfamily also contains many F-box only proteins that do not have any WD repeat. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438928  Cd Length: 39  Bit Score: 34.36  E-value: 3.43e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1032286088  29 SLPVDLLISILARVsrldyPILSL-----VSKSFRSLIASPE 65
Cdd:cd22157     2 SLPDDLVEEILSRL-----PAKSLlrfrcVCKQWNSLISSPS 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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