|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02925 |
PLN02925 |
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase |
1-740 |
0e+00 |
|
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase
Pssm-ID: 178513 Cd Length: 733 Bit Score: 1568.98 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032280961 1 MATGVLPAPVSGIKIPDSKVGFGKSMNLVRICDVRslrsarrRVSVIRNSNQGSDLAELQPASEGSPLLVPRQKYCESLH 80
Cdd:PLN02925 1 MATGVLPAPLSGLKTSDSKLGFGKSMDFVRICDVR-------SVSVIRNSNTGPDLVELQPASEGSPLLVPRQKYCESIH 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032280961 81 KTVRRKTRTVMVGNVALGSEHPIRIQTMTTSDTKDITGTVDEVMRIADKGADIVRITVQGKKEADACFEIKDKLVQLNYN 160
Cdd:PLN02925 74 KTVRRKTRTVMVGNVALGSEHPIRIQTMTTTDTKDVEATVDQVMRIADKGADIVRITVQGKKEADACFEIKNTLVQKGYN 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032280961 161 IPLVADIHFAPTVALRVAECFDKIRVNPGNFADRRAQFETIDYTEDEYQKELQHIEQVFTPLVEKCKKYGRAMRIGTNHG 240
Cdd:PLN02925 154 IPLVADIHFAPSVALRVAECFDKIRVNPGNFADRRAQFEKLEYTEDDYQKELEHIEEVFTPLVEKCKKYGRAMRIGTNHG 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032280961 241 SLSDRIMSYYGDSPRGMVESAFEFARICRKLDYHNFVFSMKASNPVIMVQAYRLLVAEMYVHGWDYPLHLGVTEAGEGED 320
Cdd:PLN02925 234 SLSDRIMSYYGDSPRGMVESAFEFARICRKLDYHNFVFSMKASNPVVMVQAYRLLVAEMYVLGWDYPLHLGVTEAGEGED 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032280961 321 GRMKSAIGIGTLLQDGLGDTIRVSLTEPPEEEIDPCRRLANLGTKAAKLQQGVAPFEEKHRHYFDFQRRTGDLPVQKEGE 400
Cdd:PLN02925 314 GRMKSAIGIGTLLQDGLGDTIRVSLTEPPEEEIDPCRRLANLGMKAAALQQGVAPFEEKHRDYFDFQRRTGQLPVQKEGE 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032280961 401 EVDYRNVLHRDGSVLMSISLDQLKAPELLYRSLATKLVVGMPFKDLATVDSILLRELPPVDDQVARLALKRLIDVSMGVI 480
Cdd:PLN02925 394 EVDYRNVLHRDGSVLMSVSLDQLKAPELLYRSLAAKLVVGMPFKDLATVDSILLRELPPVDDEEARLALKRLIDVSMGVI 473
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032280961 481 APLSEQLTKPLPNAMVLVNLKELSGGAYKLLPEGTRLVVSLRGDEPYEELEILKNIDATMILHDVPFTEDKVSRVHAARR 560
Cdd:PLN02925 474 APLSEQLTKPLPNAMALVNLKELSSGAHKLLPEGTRLAVTLRGDEPYEELEILKDVDATMLLHDVPFTEDKVSRVHAARR 553
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032280961 561 LFEFLSENSVNFPVIHHINFPTGIHRDELVIHAGTYAGGLLVDGLGDGVMLEAPDQDFDFLRNTSFNLLQGCRMRNTKTE 640
Cdd:PLN02925 554 LFEYLSSNSLNFPVIHHIQFPAGIHRDDLVIQAGSQAGALLVDGLGDGVLLEAPDQDFDFLRNTSFGLLQGCRMRNTKTE 633
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032280961 641 YVSCPSCGRTLFDLQEISAEIREKTSHLPGVSIAIMGCIVNGPGEMADADFGYVGGSPGKIDLYVGKTVVKRGIAMTEAT 720
Cdd:PLN02925 634 YVSCPSCGRTLFDLQEVSAEIREKTSHLPGVSIAIMGCIVNGPGEMADADFGYVGGAPGKIDLYVGKEVVKRGIAMEEAT 713
|
730 740
....*....|....*....|
gi 1032280961 721 DALIGLIKEHGRWVDPPVAD 740
Cdd:PLN02925 714 DALIQLIKDHGRWVDPEVEE 733
|
|
| GcpE |
pfam04551 |
GcpE protein; In a variety of organizms, including plants and several eubacteria, isoprenoids ... |
87-359 |
8.00e-128 |
|
GcpE protein; In a variety of organizms, including plants and several eubacteria, isoprenoids are synthesized by the mevalonate-independent 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway. Although different enzymes of this pathway have been described, the terminal biosynthetic steps of the MEP pathway have not been fully elucidated. GcpE gene of Escherichia coli is involved in this pathway.
Pssm-ID: 428003 [Multi-domain] Cd Length: 343 Bit Score: 383.61 E-value: 8.00e-128
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032280961 87 TRTVMVGNVALGSEHPIRIQTMTTSDTKDITGTVDEVMRIADKGADIVRITVQGKKEADACFEIKDKLvqlnyNIPLVAD 166
Cdd:pfam04551 1 TRQVRVGNVPIGGGAPIVVQSMTNTDTRDVEATVAQIRRLAEAGCEIVRVAVPDMEAAEALKEIKKRL-----PIPLVAD 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032280961 167 IHFAPTVALRVAEC-FDKIRVNPGNFADRRAqfetidytedeyqkelqhieqvFTPLVEKCKKYGRAMRIGTNHGSLSDR 245
Cdd:pfam04551 76 IHFDYRLALEAAEAgVDKIRINPGNIGSEEK----------------------VREVVEAAKERGIPIRIGVNSGSLEKD 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032280961 246 IMSYYGD-SPRGMVESAFEFARICRKLDYHNFVFSMKASNPVIMVQAYRLLVAEMyvhgwDYPLHLGVTEAGEGEDGRMK 324
Cdd:pfam04551 134 LLEKYGGpTPEALVESALEHVRILEELGFDDIVISLKASDVPLTVEAYRLLAERC-----DYPLHLGVTEAGTGESGTIK 208
|
250 260 270
....*....|....*....|....*....|....*
gi 1032280961 325 SAIGIGTLLQDGLGDTIRVSLTEPPEEEIDPCRRL 359
Cdd:pfam04551 209 SAVGIGALLAEGIGDTIRVSLTGDPVEEVKVAKEI 243
|
|
| IspG |
COG0821 |
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase IspG/GcpE [Lipid transport and metabolism] ... |
84-353 |
8.24e-110 |
|
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase IspG/GcpE [Lipid transport and metabolism]; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase IspG/GcpE is part of the Pathway/BioSystem: Isoprenoid biosynthesis
Pssm-ID: 440583 [Multi-domain] Cd Length: 363 Bit Score: 337.78 E-value: 8.24e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032280961 84 RRKTRTVMVGNVALGSEHPIRIQTMTTSDTKDITGTVDEVMRIADKGADIVRITVQGKKEADACFEIKDKLvqlnyNIPL 163
Cdd:COG0821 8 RRKTRQVRVGNVAIGGGAPISVQSMTNTDTADVEATVAQIKALAEAGCEIVRVAVPDEEAAAALPEIKKQL-----PVPL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032280961 164 VADIHFAPTVALRVAECF-DKIRVNPGNFADRRAqfetidytedeyqkelqhieqvFTPLVEKCKKYGRAMRIGTNHGSL 242
Cdd:COG0821 83 VADIHFDYRLALEAAEAGvDKLRINPGNIGSDEK----------------------VREVVEAAKERGIPIRIGVNAGSL 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032280961 243 SDRIMSYYGD-SPRGMVESAFEFARICRKLDYHNFVFSMKASNPVIMVQAYRLLVAEMyvhgwDYPLHLGVTEAGEGEDG 321
Cdd:COG0821 141 EKDLLEKYGDpTPEALVESALEHARILEELGFDDIKISLKASDVQDTIAAYRLLAERC-----DYPLHLGVTEAGTGRKG 215
|
250 260 270
....*....|....*....|....*....|..
gi 1032280961 322 RMKSAIGIGTLLQDGLGDTIRVSLTEPPEEEI 353
Cdd:COG0821 216 TVKSAAGLGILLAEGIGDTIRVSLTADPVEEV 247
|
|
| ispG_gcpE |
TIGR00612 |
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; This protein of previously unknown ... |
84-366 |
1.04e-104 |
|
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; This protein of previously unknown biochemical function has now been identified as an enzyme of the non-mevalonate pathway of IPP biosynthesis. Chlamydial members of the family have a long insert. The family is largely restricted to Bacteria, where it is widely but not universally distributed. No homology can be detected between the GcpE family and other proteins. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]
Pssm-ID: 273174 [Multi-domain] Cd Length: 346 Bit Score: 323.99 E-value: 1.04e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032280961 84 RRKTRTVMVGNVALGSEHPIRIQTMTTSDTKDITGTVDEVMRIADKGADIVRITVQGKKEADACFEIKDKLvqlnyNIPL 163
Cdd:TIGR00612 1 RRKTRQVRVGNVKVGGDAPIVVQSMTNTDTHDVDATVAQIRRLEEAGCEIVRVTVPDKESAEALEEIKEGS-----NVPL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032280961 164 VADIHFAPTVALR-VAECFDKIRVNPGNFADRRaqfetidytedeyqkelqhieqVFTPLVEKCKKYGRAMRIGTNHGSL 242
Cdd:TIGR00612 76 VADIHFAYSYAALaMAKGVAKVRINPGNIGFEE----------------------RVRDIVEKARRHGKAMRIGVNHGSL 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032280961 243 SDRIMSYYGD-SPRGMVESAFEFARICRKLDYHNFVFSMKASNPVIMVQAYRLLVAEMyvhgwDYPLHLGVTEAGEGEDG 321
Cdd:TIGR00612 134 ERRLLEKYGDpTAEAMVQSALEWAEILEKLGFRNVVVSMKASDVLQTVAAYRLLAERS-----DYPLHLGVTEAGMGVKG 208
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 1032280961 322 RMKSAIGIGTLLQDGLGDTIRVSLTEPPEEEIDPCRR-LANLGTKA 366
Cdd:TIGR00612 209 IIKSSVGIGILLAMGIGDTIRVSLTDDPVVEVPVAYEiLQSLGLRR 254
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02925 |
PLN02925 |
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase |
1-740 |
0e+00 |
|
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase
Pssm-ID: 178513 Cd Length: 733 Bit Score: 1568.98 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032280961 1 MATGVLPAPVSGIKIPDSKVGFGKSMNLVRICDVRslrsarrRVSVIRNSNQGSDLAELQPASEGSPLLVPRQKYCESLH 80
Cdd:PLN02925 1 MATGVLPAPLSGLKTSDSKLGFGKSMDFVRICDVR-------SVSVIRNSNTGPDLVELQPASEGSPLLVPRQKYCESIH 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032280961 81 KTVRRKTRTVMVGNVALGSEHPIRIQTMTTSDTKDITGTVDEVMRIADKGADIVRITVQGKKEADACFEIKDKLVQLNYN 160
Cdd:PLN02925 74 KTVRRKTRTVMVGNVALGSEHPIRIQTMTTTDTKDVEATVDQVMRIADKGADIVRITVQGKKEADACFEIKNTLVQKGYN 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032280961 161 IPLVADIHFAPTVALRVAECFDKIRVNPGNFADRRAQFETIDYTEDEYQKELQHIEQVFTPLVEKCKKYGRAMRIGTNHG 240
Cdd:PLN02925 154 IPLVADIHFAPSVALRVAECFDKIRVNPGNFADRRAQFEKLEYTEDDYQKELEHIEEVFTPLVEKCKKYGRAMRIGTNHG 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032280961 241 SLSDRIMSYYGDSPRGMVESAFEFARICRKLDYHNFVFSMKASNPVIMVQAYRLLVAEMYVHGWDYPLHLGVTEAGEGED 320
Cdd:PLN02925 234 SLSDRIMSYYGDSPRGMVESAFEFARICRKLDYHNFVFSMKASNPVVMVQAYRLLVAEMYVLGWDYPLHLGVTEAGEGED 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032280961 321 GRMKSAIGIGTLLQDGLGDTIRVSLTEPPEEEIDPCRRLANLGTKAAKLQQGVAPFEEKHRHYFDFQRRTGDLPVQKEGE 400
Cdd:PLN02925 314 GRMKSAIGIGTLLQDGLGDTIRVSLTEPPEEEIDPCRRLANLGMKAAALQQGVAPFEEKHRDYFDFQRRTGQLPVQKEGE 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032280961 401 EVDYRNVLHRDGSVLMSISLDQLKAPELLYRSLATKLVVGMPFKDLATVDSILLRELPPVDDQVARLALKRLIDVSMGVI 480
Cdd:PLN02925 394 EVDYRNVLHRDGSVLMSVSLDQLKAPELLYRSLAAKLVVGMPFKDLATVDSILLRELPPVDDEEARLALKRLIDVSMGVI 473
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032280961 481 APLSEQLTKPLPNAMVLVNLKELSGGAYKLLPEGTRLVVSLRGDEPYEELEILKNIDATMILHDVPFTEDKVSRVHAARR 560
Cdd:PLN02925 474 APLSEQLTKPLPNAMALVNLKELSSGAHKLLPEGTRLAVTLRGDEPYEELEILKDVDATMLLHDVPFTEDKVSRVHAARR 553
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032280961 561 LFEFLSENSVNFPVIHHINFPTGIHRDELVIHAGTYAGGLLVDGLGDGVMLEAPDQDFDFLRNTSFNLLQGCRMRNTKTE 640
Cdd:PLN02925 554 LFEYLSSNSLNFPVIHHIQFPAGIHRDDLVIQAGSQAGALLVDGLGDGVLLEAPDQDFDFLRNTSFGLLQGCRMRNTKTE 633
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032280961 641 YVSCPSCGRTLFDLQEISAEIREKTSHLPGVSIAIMGCIVNGPGEMADADFGYVGGSPGKIDLYVGKTVVKRGIAMTEAT 720
Cdd:PLN02925 634 YVSCPSCGRTLFDLQEVSAEIREKTSHLPGVSIAIMGCIVNGPGEMADADFGYVGGAPGKIDLYVGKEVVKRGIAMEEAT 713
|
730 740
....*....|....*....|
gi 1032280961 721 DALIGLIKEHGRWVDPPVAD 740
Cdd:PLN02925 714 DALIQLIKDHGRWVDPEVEE 733
|
|
| PRK00694 |
PRK00694 |
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated |
78-736 |
0e+00 |
|
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated
Pssm-ID: 234812 Cd Length: 606 Bit Score: 583.34 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032280961 78 SLHKTVRRKTRTVMVGNVALGSEHPIRIQTMTTSDTKDITGTVDEVMRIADKGADIVRITVQGKKEADACFEIKDKLVQL 157
Cdd:PRK00694 6 CIQNAFRRKTHPVRIGNLFVGSEHSIKIQSMTTTATTDVDGTVRQICALQEWGCDIVRVTVQGLKEAQACEHIKERLIQQ 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032280961 158 NYNIPLVADIHFAPTVALRVAECFDKIRVNPGNFADRRAQFETIDYTEDEYQKELQHIEQVFTPLVEKCKKYGRAMRIGT 237
Cdd:PRK00694 86 GISIPLVADIHFFPQAAMHVADFVDKVRINPGNYVDKRNMFTGKIYTDEQYAHSLLRLEEKFSPLVEKCKRLGKAMRIGV 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032280961 238 NHGSLSDRIMSYYGDSPRGMVESAFEFARICRKLDYHNFVFSMKASNPVIMVQAYRLLVAEMYVHGWDYPLHLGVTEAGE 317
Cdd:PRK00694 166 NHGSLSERVMQRYGDTIEGMVYSALEYIEVCEKLDYRDVVFSMKSSNPKVMVAAYRQLAKDLDARGWLYPLHLGVTEAGS 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032280961 318 GEDGRMKSAIGIGTLLQDGLGDTIRVSLTEPPEEEIDPCRRLANLGTKAAKLQQGVAPFEEKHRHYFDFQrrtgdlpVQK 397
Cdd:PRK00694 246 GTDGIIKSAVGIGTLLSEGLGDTIRCSLTGCPTNEIPVCISLLKHTTEYLELPEKDNPFALHHSEQFVSA-------TRK 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032280961 398 EGEEVDYRNVLhrdgSVLMSISLDQL--KAPELLYRSLATKLVVGMpfKDLATVDsillrelppvddqvarlalkrlidv 475
Cdd:PRK00694 319 TLKTTPWGNVY----GVFIKLTDVHLltAEPEELLECLGIDPTTGK--KDFTTPE------------------------- 367
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032280961 476 smGVIAPlseqltKPLPNAMVLVNLKElsggaykllpegtRLVVSLRGDEP--YEELEILKNIDATmilHDVPFTEDKVS 553
Cdd:PRK00694 368 --GVVVP------KAMRSSPIVSELEK-------------HLLVFHHHDVPclYEMNEEIWLSEEV---LSAPFVHFHAT 423
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032280961 554 --RVHAARRLFEFLSENSVnfPVihHINFPTGIH-RDELVIHAGTYAGGLLVDGLGDGVMLEAPDQDFDFLRNTSFNLLQ 630
Cdd:PRK00694 424 dpFIHTARRFFSKRQHSTQ--PV--KLVFSLDPDsKNEAAIDIATEFGALLLDGLGECVLLDLPNIKLSDVRTIAFGTLQ 499
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032280961 631 GCRMRNTKTEYVSCPSCGRTLFDLQEISAEIREKTSHLPGVSIAIMGCIVNGPGEMADADFGYVGGSPGKIDLYVGKTVV 710
Cdd:PRK00694 500 SAGVRLVKTEYISCPGCGRTLFDLLEVTQRIRERTQHLPGLKIAVMGCIVNGPGEMADADFGFVGSKTGMIDLYVKHTCV 579
|
650 660
....*....|....*....|....*.
gi 1032280961 711 KRGIAMTEATDALIGLIKEHGRWVDP 736
Cdd:PRK00694 580 KAHIPMENAEEELVQLLKEHGVWKDP 605
|
|
| PRK02048 |
PRK02048 |
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Provisional |
84-734 |
0e+00 |
|
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Provisional
Pssm-ID: 179361 Cd Length: 611 Bit Score: 540.96 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032280961 84 RRKTRTVMVGNVALGSEHPIRIQTMTTSDTKDITGTVDEVMRIADKGADIVRITVQGKKEADACFEIKDKLVQLNYNIPL 163
Cdd:PRK02048 8 RRKTSVVNIGATPLGGPNPIRIQSMTNTSTMDTEACVAQAKRIIDAGGEYVRLTTQGVREAENLMNINIGLRSQGYMVPL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032280961 164 VADIHFAPTVALRVAECFDKIRVNPGNFADRRAQFETIDYTEDEYQKELQHIEQVFTPLVEKCKKYGRAMRIGTNHGSLS 243
Cdd:PRK02048 88 VADVHFNPKVADVAAQYAEKVRINPGNYVDPGRTFKKLEYTDEEYAQEIQKIRDRFVPFLNICKENHTAIRIGVNHGSLS 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032280961 244 DRIMSYYGDSPRGMVESAFEFARICRKLDYHNFVFSMKASNPVIMVQAYRLLVAEMYVHGWDYPLHLGVTEAGEGEDGRM 323
Cdd:PRK02048 168 DRIMSRYGDTPEGMVESCMEFLRICVEEHFTDVVISIKASNTVVMVRTVRLLVAVMEAEGMHYPLHLGVTEAGDGEDGRI 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032280961 324 KSAIGIGTLLQDGLGDTIRVSLTEPPEEEIDPCRRLanlgtkaaklqqgVAPFEEKHRHYFdfqrrtgdLPVqKEGEEVD 403
Cdd:PRK02048 248 KSAVGIGALLADGIGDTIRVSLSEEPEAEIPVARKL-------------VDYIRSRENHPY--------IPG-MEAPGFD 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032280961 404 YRNVLHRDGSVLMSISLDQLKApellyrSLATKLVVGMPFKDLATVDSILL-RELPP-VDDQVARLALKRLIDVSMGVIa 481
Cdd:PRK02048 306 YLSPSRRKTRAVRNIGGDHLPV------VIADRMDGDFEFDPQFLPDYIYAgRELPEqREPGVQYILDADVWKEEPNTW- 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032280961 482 plseqltkPLPNAMVLVNLKELSgGAYKLLpegtrlvvSLRGDEPYEE-LEILKNIDATMILhdvpFTEDKVSRVHAARR 560
Cdd:PRK02048 379 --------PAFNYAQLELMETCA-AELKFL--------FLPYMALTDEvLACLKAHPEVVVI----LQSNHPNRVGEHRA 437
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032280961 561 LFEFLSENSVNFPVIHHINFPTGiHRDELVIHAGTYAGGLLVDGLGDGVML----EAPDQDFDflrNTSFNLLQGCRMRN 636
Cdd:PRK02048 438 LAHQLMVAGLENPVIFFQHYAET-TAEDLQLKAAADMGALIFDGLCDGIFLfnqgKLSHVVVD---ATAFGILQAGRLRT 513
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032280961 637 TKTEYVSCPSCGRTLFDLQEISAEIREKTSHLPGVSIAIMGCIVNGPGEMADADFGYVGGSPGKIDLYVGKTVVKRGIAM 716
Cdd:PRK02048 514 SKTEYISCPGCGRTLYDLQSTIARIKEATSHLKGLKIGIMGCIVNGPGEMADADYGYVGAGRGKISLYKQKECVEKNIPE 593
|
650
....*....|....*...
gi 1032280961 717 TEATDALIGLIKEHGRWV 734
Cdd:PRK02048 594 EEAVERLIELIKANGDWE 611
|
|
| GcpE |
pfam04551 |
GcpE protein; In a variety of organizms, including plants and several eubacteria, isoprenoids ... |
87-359 |
8.00e-128 |
|
GcpE protein; In a variety of organizms, including plants and several eubacteria, isoprenoids are synthesized by the mevalonate-independent 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway. Although different enzymes of this pathway have been described, the terminal biosynthetic steps of the MEP pathway have not been fully elucidated. GcpE gene of Escherichia coli is involved in this pathway.
Pssm-ID: 428003 [Multi-domain] Cd Length: 343 Bit Score: 383.61 E-value: 8.00e-128
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032280961 87 TRTVMVGNVALGSEHPIRIQTMTTSDTKDITGTVDEVMRIADKGADIVRITVQGKKEADACFEIKDKLvqlnyNIPLVAD 166
Cdd:pfam04551 1 TRQVRVGNVPIGGGAPIVVQSMTNTDTRDVEATVAQIRRLAEAGCEIVRVAVPDMEAAEALKEIKKRL-----PIPLVAD 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032280961 167 IHFAPTVALRVAEC-FDKIRVNPGNFADRRAqfetidytedeyqkelqhieqvFTPLVEKCKKYGRAMRIGTNHGSLSDR 245
Cdd:pfam04551 76 IHFDYRLALEAAEAgVDKIRINPGNIGSEEK----------------------VREVVEAAKERGIPIRIGVNSGSLEKD 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032280961 246 IMSYYGD-SPRGMVESAFEFARICRKLDYHNFVFSMKASNPVIMVQAYRLLVAEMyvhgwDYPLHLGVTEAGEGEDGRMK 324
Cdd:pfam04551 134 LLEKYGGpTPEALVESALEHVRILEELGFDDIVISLKASDVPLTVEAYRLLAERC-----DYPLHLGVTEAGTGESGTIK 208
|
250 260 270
....*....|....*....|....*....|....*
gi 1032280961 325 SAIGIGTLLQDGLGDTIRVSLTEPPEEEIDPCRRL 359
Cdd:pfam04551 209 SAVGIGALLAEGIGDTIRVSLTGDPVEEVKVAKEI 243
|
|
| IspG |
COG0821 |
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase IspG/GcpE [Lipid transport and metabolism] ... |
84-353 |
8.24e-110 |
|
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase IspG/GcpE [Lipid transport and metabolism]; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase IspG/GcpE is part of the Pathway/BioSystem: Isoprenoid biosynthesis
Pssm-ID: 440583 [Multi-domain] Cd Length: 363 Bit Score: 337.78 E-value: 8.24e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032280961 84 RRKTRTVMVGNVALGSEHPIRIQTMTTSDTKDITGTVDEVMRIADKGADIVRITVQGKKEADACFEIKDKLvqlnyNIPL 163
Cdd:COG0821 8 RRKTRQVRVGNVAIGGGAPISVQSMTNTDTADVEATVAQIKALAEAGCEIVRVAVPDEEAAAALPEIKKQL-----PVPL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032280961 164 VADIHFAPTVALRVAECF-DKIRVNPGNFADRRAqfetidytedeyqkelqhieqvFTPLVEKCKKYGRAMRIGTNHGSL 242
Cdd:COG0821 83 VADIHFDYRLALEAAEAGvDKLRINPGNIGSDEK----------------------VREVVEAAKERGIPIRIGVNAGSL 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032280961 243 SDRIMSYYGD-SPRGMVESAFEFARICRKLDYHNFVFSMKASNPVIMVQAYRLLVAEMyvhgwDYPLHLGVTEAGEGEDG 321
Cdd:COG0821 141 EKDLLEKYGDpTPEALVESALEHARILEELGFDDIKISLKASDVQDTIAAYRLLAERC-----DYPLHLGVTEAGTGRKG 215
|
250 260 270
....*....|....*....|....*....|..
gi 1032280961 322 RMKSAIGIGTLLQDGLGDTIRVSLTEPPEEEI 353
Cdd:COG0821 216 TVKSAAGLGILLAEGIGDTIRVSLTADPVEEV 247
|
|
| ispG |
PRK00366 |
flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase; |
84-353 |
9.27e-108 |
|
flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase;
Pssm-ID: 234737 [Multi-domain] Cd Length: 360 Bit Score: 332.42 E-value: 9.27e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032280961 84 RRKTRTVMVGNVALGSEHPIRIQTMTTSDTKDITGTVDEVMRIADKGADIVRITVQGKKEADACFEIKDKLvqlnyNIPL 163
Cdd:PRK00366 9 RRKTRQVKVGNVPIGGDAPIVVQSMTNTDTADVEATVAQIKRLARAGCEIVRVAVPDMEAAAALPEIKKQL-----PVPL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032280961 164 VADIHFAPTVALRVAE-CFDKIRVNPGNFADRRAQFETIdytedeyqkelqhieqvftplVEKCKKYGRAMRIGTNHGSL 242
Cdd:PRK00366 84 VADIHFDYRLALAAAEaGADALRINPGNIGKRDERVREV---------------------VEAAKDYGIPIRIGVNAGSL 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032280961 243 SDRIMSYYGD-SPRGMVESAFEFARICRKLDYHNFVFSMKASNPVIMVQAYRLLVAEMyvhgwDYPLHLGVTEAGEGEDG 321
Cdd:PRK00366 143 EKDLLEKYGEpTPEALVESALRHAKILEELGFDDIKISVKASDVQDLIAAYRLLAKRC-----DYPLHLGVTEAGMGFKG 217
|
250 260 270
....*....|....*....|....*....|..
gi 1032280961 322 RMKSAIGIGTLLQDGLGDTIRVSLTEPPEEEI 353
Cdd:PRK00366 218 TVKSAAGLGALLQEGIGDTIRVSLTADPVEEV 249
|
|
| ispG_gcpE |
TIGR00612 |
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; This protein of previously unknown ... |
84-366 |
1.04e-104 |
|
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; This protein of previously unknown biochemical function has now been identified as an enzyme of the non-mevalonate pathway of IPP biosynthesis. Chlamydial members of the family have a long insert. The family is largely restricted to Bacteria, where it is widely but not universally distributed. No homology can be detected between the GcpE family and other proteins. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]
Pssm-ID: 273174 [Multi-domain] Cd Length: 346 Bit Score: 323.99 E-value: 1.04e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032280961 84 RRKTRTVMVGNVALGSEHPIRIQTMTTSDTKDITGTVDEVMRIADKGADIVRITVQGKKEADACFEIKDKLvqlnyNIPL 163
Cdd:TIGR00612 1 RRKTRQVRVGNVKVGGDAPIVVQSMTNTDTHDVDATVAQIRRLEEAGCEIVRVTVPDKESAEALEEIKEGS-----NVPL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032280961 164 VADIHFAPTVALR-VAECFDKIRVNPGNFADRRaqfetidytedeyqkelqhieqVFTPLVEKCKKYGRAMRIGTNHGSL 242
Cdd:TIGR00612 76 VADIHFAYSYAALaMAKGVAKVRINPGNIGFEE----------------------RVRDIVEKARRHGKAMRIGVNHGSL 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032280961 243 SDRIMSYYGD-SPRGMVESAFEFARICRKLDYHNFVFSMKASNPVIMVQAYRLLVAEMyvhgwDYPLHLGVTEAGEGEDG 321
Cdd:TIGR00612 134 ERRLLEKYGDpTAEAMVQSALEWAEILEKLGFRNVVVSMKASDVLQTVAAYRLLAERS-----DYPLHLGVTEAGMGVKG 208
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 1032280961 322 RMKSAIGIGTLLQDGLGDTIRVSLTEPPEEEIDPCRR-LANLGTKA 366
Cdd:TIGR00612 209 IIKSSVGIGILLAMGIGDTIRVSLTDDPVVEVPVAYEiLQSLGLRR 254
|
|
| GcpE |
pfam04551 |
GcpE protein; In a variety of organizms, including plants and several eubacteria, isoprenoids ... |
598-729 |
3.91e-38 |
|
GcpE protein; In a variety of organizms, including plants and several eubacteria, isoprenoids are synthesized by the mevalonate-independent 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway. Although different enzymes of this pathway have been described, the terminal biosynthetic steps of the MEP pathway have not been fully elucidated. GcpE gene of Escherichia coli is involved in this pathway.
Pssm-ID: 428003 [Multi-domain] Cd Length: 343 Bit Score: 145.17 E-value: 3.91e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032280961 598 GGLLVDGLGDG--VML-EAPDQDFDflrnTSFNLLQGCRMRNTKTEYVSCPSCGRTLFDLQEISAEIREKTSHLP-GVSI 673
Cdd:pfam04551 214 GALLAEGIGDTirVSLtGDPVEEVK----VAKEILQSLGLRKRGVEIISCPTCGRTEIDLIELAEEVEERLEHLKkPLKV 289
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 1032280961 674 AIMGCIVNGPGEMADADFGYVGGSpGKIDLYVGKTVVkRGIAMTEATDALIGLIKE 729
Cdd:pfam04551 290 AVMGCVVNGPGEAKEADIGIAGGK-GEGLLFKKGEIV-RKVPEEELVEELLEEIEK 343
|
|
| ispG_gcpE |
TIGR00612 |
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; This protein of previously unknown ... |
598-728 |
3.71e-34 |
|
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; This protein of previously unknown biochemical function has now been identified as an enzyme of the non-mevalonate pathway of IPP biosynthesis. Chlamydial members of the family have a long insert. The family is largely restricted to Bacteria, where it is widely but not universally distributed. No homology can be detected between the GcpE family and other proteins. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]
Pssm-ID: 273174 [Multi-domain] Cd Length: 346 Bit Score: 133.70 E-value: 3.71e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032280961 598 GGLLVDGLGDGV---MLEAPDQDFDflrnTSFNLLQGCRMRNTKTEYVSCPSCGRTLFDLQEISAEIREKTSHLPG-VSI 673
Cdd:TIGR00612 217 GILLAMGIGDTIrvsLTDDPVVEVP----VAYEILQSLGLRRRGVEIVACPSCGRTGFDLEKVVKEVQEALSHLKTpLKV 292
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 1032280961 674 AIMGCIVNGPGEMADADFGYVGGSPGKIDLYVGKTvVKRGIAMTEATDALIGLIK 728
Cdd:TIGR00612 293 AVMGCVVNGPGEAKHADIGISGPGTGFAWLFKHGK-PKAKVPETDMVDELIKLIQ 346
|
|
| IspG |
COG0821 |
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase IspG/GcpE [Lipid transport and metabolism] ... |
626-729 |
4.59e-24 |
|
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase IspG/GcpE [Lipid transport and metabolism]; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase IspG/GcpE is part of the Pathway/BioSystem: Isoprenoid biosynthesis
Pssm-ID: 440583 [Multi-domain] Cd Length: 363 Bit Score: 104.35 E-value: 4.59e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032280961 626 FNLLQGCRMRNTKTEYVSCPSCGRTLFDLQEISAEIREKTSHLP-GVSIAIMGCIVNGPGEMADADFGYVGGsPGKIDLY 704
Cdd:COG0821 251 QEILKSLGLRSRGPEVISCPTCGRTEIDLIQLAEEVEERLRDIKePLKVAVMGCVVNGPGEAKEADIGIAGG-GGEGLLF 329
|
90 100
....*....|....*....|....*.
gi 1032280961 705 V-GKTVVKrgIAMTEATDALIGLIKE 729
Cdd:COG0821 330 KkGEIIRK--VPEDEIVEELLEEIEK 353
|
|
| ispG |
PRK00366 |
flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase; |
626-711 |
2.66e-23 |
|
flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase;
Pssm-ID: 234737 [Multi-domain] Cd Length: 360 Bit Score: 102.07 E-value: 2.66e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032280961 626 FNLLQGCRMRNTKTEYVSCPSCGRTLFDLQEISAEIREKTSHLPG-VSIAIMGCIVNGPGEMADADFGYVGGSPgKIDLY 704
Cdd:PRK00366 253 QEILQSLGLRSRGPEVISCPTCGRTEFDVIQELAEVEQRLEHIKMpLKVAVMGCVVNGPGEAKEADIGIAGGNP-KGPVF 331
|
....*...
gi 1032280961 705 V-GKTVVK 711
Cdd:PRK00366 332 VdGEKIKT 339
|
|
| |
