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Conserved domains on  [gi|1026919863|gb|OAF68391|]
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hypothetical protein A3Q56_03826 [Intoshia linei]

Protein Classification

YEATS domain-containing protein( domain architecture ID 13014308)

YEATS (Yaf9, ENL, AF9, Taf14, and Sas5) domain-containing protein may act as a reader of the chromatin state and may stimulate transcriptional activity through preferential interactions with crotonylated lysines on histones; similar to Homo sapiens YEATS domain-containing protein 4

CATH:  2.60.40.1970
Gene Ontology:  GO:0006355
PubMed:  19234524|27661789|28300602|35041380
SCOP:  4007347

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YEATS_GAS41_like cd16909
YEATS domain found in YEATS domain-containing protein 4 and similar proteins; glioma amplified ...
 13-148 3.76e-78

YEATS domain found in YEATS domain-containing protein 4 and similar proteins; glioma amplified sequence 41 (GAS41, also known as, YEATS domain-containing protein 4, NuMA-binding protein 1 ) is a YEATS domain family protein that is amplified and acts as an oncogene in human glioma. GAS41 is a YEATS domain family protein and has been shown to interact with the general transcription factor TFIIF via the YEATS domain. DNA regulation by chromatin thru histone post-translational modification and other mechanism involves complexes with write, eraser and reader functions. YEATS domains act as readers of the chromatin state, and stimulate transcriptional activity, thru preferential interactions with crotonylated lysines on histones. The YEATS family is named for several family members: 'YNK7', 'ENL', 'AF-9', and 'TFIIF small subunit', and also contains the GAS41 protein.


:

Pssm-ID: 341128  Cd Length: 137  Bit Score: 231.37  E-value: 3.76e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026919863  13 TTIIKPILYGNKARYFGQTR-DDGFTHEWTVYVKPYFDEDVSKYIKKVHFKLHESYQNSVRVINEPPFQVNEAGWGEFDI 91
Cdd:cd16909     1 VTIVKPIVYGNIARYFGKKReEDGHTHQWTVYVKPYFNEDMSTYVKKVQFKLHESYANPLRVVTKPPYEVTETGWGEFEI 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1026919863  92 HIRIYFTETTEKAVSFVHHLTLFPPGQQRIFTSGLHKYEFYDELIFSDPPLTFHKIL 148
Cdd:cd16909    81 IIKIFFIDPNERPVTLYHLLKLFQSDTNLMLGKKTLVSEFYDELIFQDPTAMMYQLL 137
 
Name Accession Description Interval E-value
YEATS_GAS41_like cd16909
YEATS domain found in YEATS domain-containing protein 4 and similar proteins; glioma amplified ...
 13-148 3.76e-78

YEATS domain found in YEATS domain-containing protein 4 and similar proteins; glioma amplified sequence 41 (GAS41, also known as, YEATS domain-containing protein 4, NuMA-binding protein 1 ) is a YEATS domain family protein that is amplified and acts as an oncogene in human glioma. GAS41 is a YEATS domain family protein and has been shown to interact with the general transcription factor TFIIF via the YEATS domain. DNA regulation by chromatin thru histone post-translational modification and other mechanism involves complexes with write, eraser and reader functions. YEATS domains act as readers of the chromatin state, and stimulate transcriptional activity, thru preferential interactions with crotonylated lysines on histones. The YEATS family is named for several family members: 'YNK7', 'ENL', 'AF-9', and 'TFIIF small subunit', and also contains the GAS41 protein.


Pssm-ID: 341128  Cd Length: 137  Bit Score: 231.37  E-value: 3.76e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026919863  13 TTIIKPILYGNKARYFGQTR-DDGFTHEWTVYVKPYFDEDVSKYIKKVHFKLHESYQNSVRVINEPPFQVNEAGWGEFDI 91
Cdd:cd16909     1 VTIVKPIVYGNIARYFGKKReEDGHTHQWTVYVKPYFNEDMSTYVKKVQFKLHESYANPLRVVTKPPYEVTETGWGEFEI 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1026919863  92 HIRIYFTETTEKAVSFVHHLTLFPPGQQRIFTSGLHKYEFYDELIFSDPPLTFHKIL 148
Cdd:cd16909    81 IIKIFFIDPNERPVTLYHLLKLFQSDTNLMLGKKTLVSEFYDELIFQDPTAMMYQLL 137
YEATS pfam03366
YEATS family; We have named this family the YEATS family, after `YNK7', `ENL', `AF-9', and ...
 36-115 9.69e-39

YEATS family; We have named this family the YEATS family, after `YNK7', `ENL', `AF-9', and `TFIIF small subunit'. This family also contains the GAS41 protein. All these proteins are thought to have a transcription stimulatory activity


Pssm-ID: 460899  Cd Length: 80  Bit Score: 129.11  E-value: 9.69e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026919863  36 FTHEWTVYVKPYFDEDVSKYIKKVHFKLHESYQNSVRVINEPPFQVNEAGWGEFDIHIRIYFTETTEKAVSFVHHLTLFP 115
Cdd:pfam03366   1 HTHKWTVYVRGLDNEDISYFIKKVVFKLHPSFANPVRVVKKPPFEVTETGWGEFEIRIKIYFKDKDEKPVTIYHDLKLHP 80
TFG3 COG5033
Transcription initiation factor IIF, auxiliary subunit [Transcription];
6-148 1.46e-24

Transcription initiation factor IIF, auxiliary subunit [Transcription];


Pssm-ID: 227366 [Multi-domain]  Cd Length: 225  Bit Score: 96.80  E-value: 1.46e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026919863   6 PNPRVRNTTIIKPILYGNKARYFGQTR-DDGFTHEWTVYVKPYFDEDVSKYIKKVHFKLHESYQNSVRVINEPPFQVNEA 84
Cdd:COG5033     3 PVKRTERLKTQRVIIPGEAKPLGNEERfPVRHTHIWLVFVRAPGKEDIATIVKKVIFKLHPTFSNPTRTIESPPFEIKET 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1026919863  85 GWGEFDIHIRIYFTETT-EKAVSFVHHLTLFP---------PGQQRIFTSGLHKY-----EFYDELIFSDPPLTFHKIL 148
Cdd:COG5033    83 GWGEFDIQIKIFFAEKAgEKTIHFYLHFGDEPyavdepvdiPVNRPDLTSELSKSgevesVYKREKRFNEPNIQALKLL 161
 
Name Accession Description Interval E-value
YEATS_GAS41_like cd16909
YEATS domain found in YEATS domain-containing protein 4 and similar proteins; glioma amplified ...
 13-148 3.76e-78

YEATS domain found in YEATS domain-containing protein 4 and similar proteins; glioma amplified sequence 41 (GAS41, also known as, YEATS domain-containing protein 4, NuMA-binding protein 1 ) is a YEATS domain family protein that is amplified and acts as an oncogene in human glioma. GAS41 is a YEATS domain family protein and has been shown to interact with the general transcription factor TFIIF via the YEATS domain. DNA regulation by chromatin thru histone post-translational modification and other mechanism involves complexes with write, eraser and reader functions. YEATS domains act as readers of the chromatin state, and stimulate transcriptional activity, thru preferential interactions with crotonylated lysines on histones. The YEATS family is named for several family members: 'YNK7', 'ENL', 'AF-9', and 'TFIIF small subunit', and also contains the GAS41 protein.


Pssm-ID: 341128  Cd Length: 137  Bit Score: 231.37  E-value: 3.76e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026919863  13 TTIIKPILYGNKARYFGQTR-DDGFTHEWTVYVKPYFDEDVSKYIKKVHFKLHESYQNSVRVINEPPFQVNEAGWGEFDI 91
Cdd:cd16909     1 VTIVKPIVYGNIARYFGKKReEDGHTHQWTVYVKPYFNEDMSTYVKKVQFKLHESYANPLRVVTKPPYEVTETGWGEFEI 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1026919863  92 HIRIYFTETTEKAVSFVHHLTLFPPGQQRIFTSGLHKYEFYDELIFSDPPLTFHKIL 148
Cdd:cd16909    81 IIKIFFIDPNERPVTLYHLLKLFQSDTNLMLGKKTLVSEFYDELIFQDPTAMMYQLL 137
YEATS_Yaf9_like cd16908
YEATS domain found in Yaf9 and similar proteins; Yaf9 is a YEATS domain family protein ...
 14-148 2.81e-47

YEATS domain found in Yaf9 and similar proteins; Yaf9 is a YEATS domain family protein essential in the function the NuA4 histone acetyltransferase complex and the SWR1-C ATP-dependent chromatin remodeling complex. Yaf9 shares structural similarity with histone chaperone Asf1, both exhibit histone H3 and H4 binding in vitro, and evidence supports both play a role in the same histone acetylation mechanism. DNA regulation by chromatin thru histone post-translational modification and other mechanism involves complexes with write, eraser and reader functions. YEATS domains act as readers of the chromatin state, and stimulate transcriptional activity, thru preferential interactions with crotonylated lysines on histones. The YEATS family is named for several family members: `YNK7', `ENL', `AF-9', and `TFIIF small subunit', and also contains the GAS41 protein.


Pssm-ID: 341127  Cd Length: 145  Bit Score: 153.20  E-value: 2.81e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026919863  14 TIIKPILYGNKARYFGQ----TRDDGFTHEWTVYVKPYFDEDVSKYIKKVHFKLHESYQNSVRVINEPPFQVNEAGWGEF 89
Cdd:cd16908     1 QVSRPIVYGNTARPLTPeekpKAPPDHTHKWTVFVRGPDGEDLSYFIKKVVFKLHESYPNPNRTIEKPPFEVTETGWGEF 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1026919863  90 DIHIRIYFT-ETTEKAVSFVHHLTLFPPGQQRIFTS----GLHKYEFYDELIFSDPPLTFHKIL 148
Cdd:cd16908    81 EIQIKIYFVpEANEKPITLYHMLKLHPYEDTAENDDlasgGPVVSVQYDEIVFNEPTEEFYDIL 144
YEATS cd16887
YEATS domain family, chromatin reader proteins; The YEATS family is named for several family ...
 17-137 6.14e-45

YEATS domain family, chromatin reader proteins; The YEATS family is named for several family members: 'YNK7', 'ENL', 'AF-9', and 'TFIIF small subunit', and also contains the GAS41 protein, YEATS2, Drosophila D12, and others. DNA regulation by chromatin through histone post-translational modification and other mechanisms involves complexes with write, eraser and reader functions. YEATS domains act as readers of the chromatin state and stimulates transcriptional activity through preferential interactions with crotonylated lysines on histones.


Pssm-ID: 341123  Cd Length: 120  Bit Score: 146.27  E-value: 6.14e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026919863  17 KPILYGNKARYFGQTRDDGFTHEWTVYVKPYFDEDVSKYIKKVHFKLHESYQNSVRVINEPPFQVNEAGWGEFDIHIRIY 96
Cdd:cd16887     1 KPIVIGNVAEKIPKPEPDDNTHKWTVYVRSPTNEDLSSFIKKVTFKLHPSFPNPVRVVTDPPFEVEEVGWGEFPIEIKIY 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1026919863  97 FTETTEKAVSFVHHLTLFPPGQQRIFTSGLHkyEFYDELIF 137
Cdd:cd16887    81 FKDSNEKPVTLSHFLKLHPDGSPLKKPVVVS--EKYDEIVF 119
YEATS_TFIID14_like cd16910
YEATS domain found in transcription initiation factor TFIID subunit 14 and similar proteins; ...
 15-144 2.64e-43

YEATS domain found in transcription initiation factor TFIID subunit 14 and similar proteins; YEATS domain containing proteins, which include Transcription initiation factor TFIID subunits 14 and 14b of Arabidopsis, shown to be part of the TFIID general transcriptional regulator complex in a two-hybrid screen. DNA regulation by chromatin thru histone post-translational modification and other mechanism involves complexes with write, eraser and reader functions. YEATS domains act as readers of the chromatin state, and stimulate transcriptional activity, thru preferential interactions with crotonylated lysines on histones. The YEATS family is named for several family members: 'YNK7', 'ENL', 'AF-9', and 'TFIIF small subunit', and also contains the GAS41 protein.


Pssm-ID: 341129  Cd Length: 131  Bit Score: 142.33  E-value: 2.64e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026919863  15 IIKPILYGNKARYFGQTRDDGFTHEWTVYVKPYFDEDVSKYIKKVHFKLHESYQNSVRVINEPPFQVNEAGWGEFDIHIR 94
Cdd:cd16910     1 VSVPIVYGSIAFWLGKKADETHTHKWTVYVRGANNEDLSYFIKKVVFVLHPSFANPTRVVTEPPFEVTETGWGEFEIGIT 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1026919863  95 IYFTETTEKAVSFVHHLTLFPP---GQQRIFTSGLHkyEFYDELIFSDPPLTF 144
Cdd:cd16910    81 IHFKDDAEKPVELTHPLKLYPPpgsGPPSTKKPVVS--EFYDEIVFVEPTEEF 131
YEATS pfam03366
YEATS family; We have named this family the YEATS family, after `YNK7', `ENL', `AF-9', and ...
 36-115 9.69e-39

YEATS family; We have named this family the YEATS family, after `YNK7', `ENL', `AF-9', and `TFIIF small subunit'. This family also contains the GAS41 protein. All these proteins are thought to have a transcription stimulatory activity


Pssm-ID: 460899  Cd Length: 80  Bit Score: 129.11  E-value: 9.69e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026919863  36 FTHEWTVYVKPYFDEDVSKYIKKVHFKLHESYQNSVRVINEPPFQVNEAGWGEFDIHIRIYFTETTEKAVSFVHHLTLFP 115
Cdd:pfam03366   1 HTHKWTVYVRGLDNEDISYFIKKVVFKLHPSFANPVRVVKKPPFEVTETGWGEFEIRIKIYFKDKDEKPVTIYHDLKLHP 80
YEATS_YEATS2_like cd16907
YEATS domain found in YEATS2 and Drosophila D12; YEATS2 is a YEATS domain reader protein with ...
 17-113 3.03e-26

YEATS domain found in YEATS2 and Drosophila D12; YEATS2 is a YEATS domain reader protein with a preference for recognition of histone H3 crotonylation on lysine 27 (H3K27crHistone crotonylation upregulates gene expression in an AF9-dependent manner. DNA regulation by chromatin thru histone post-translational modification and other mechanism involves complexes with write, eraser and reader functions. YEATS domains act as readers of the chromatin state, and stimulate transcriptional activity, thru preferential interactions with crotonylated lysines on histones. The YEATS family is named for several family members: 'YNK7', 'ENL', 'AF-9', and 'TFIIF small subunit', and also contains the GAS41 protein.


Pssm-ID: 341126  Cd Length: 123  Bit Score: 98.41  E-value: 3.03e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026919863  17 KPILYGNKARYFG--QTRDDGFTHEWTVYVK-PYFDEDVSKYIKKVHFKLHESYQ-NSVRVINEPPFQVNEAGWGEFDIH 92
Cdd:cd16907     1 KRIIVGNVSKYIPpdEREDDKSTHKWMVYVRgPPEDPDIDHFVKKVRFFLHPSYApNDVVEVTKPPFHLTRRGWGEFPVR 80

                          90       100
                  ....*....|....*....|.
gi 1026919863  93 IRIYFTETTEKAVSFVHHLTL 113
Cdd:cd16907    81 VQLHFKDPRNKPVDIIHNLKL 101
TFG3 COG5033
Transcription initiation factor IIF, auxiliary subunit [Transcription];
6-148 1.46e-24

Transcription initiation factor IIF, auxiliary subunit [Transcription];


Pssm-ID: 227366 [Multi-domain]  Cd Length: 225  Bit Score: 96.80  E-value: 1.46e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026919863   6 PNPRVRNTTIIKPILYGNKARYFGQTR-DDGFTHEWTVYVKPYFDEDVSKYIKKVHFKLHESYQNSVRVINEPPFQVNEA 84
Cdd:COG5033     3 PVKRTERLKTQRVIIPGEAKPLGNEERfPVRHTHIWLVFVRAPGKEDIATIVKKVIFKLHPTFSNPTRTIESPPFEIKET 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1026919863  85 GWGEFDIHIRIYFTETT-EKAVSFVHHLTLFP---------PGQQRIFTSGLHKY-----EFYDELIFSDPPLTFHKIL 148
Cdd:COG5033    83 GWGEFDIQIKIFFAEKAgEKTIHFYLHFGDEPyavdepvdiPVNRPDLTSELSKSgevesVYKREKRFNEPNIQALKLL 161
YEATS_AF-9_like cd16906
YEATS domain found in ENL and AF-9-like proteins; Yeast AFF9 is a YEATS domain protein that ...
 22-131 3.84e-24

YEATS domain found in ENL and AF-9-like proteins; Yeast AFF9 is a YEATS domain protein that binds to modified histones, with a preference for crotonyllysine over acetyllysine. Histone crotonylation upregulates gene expression in an AF9-dependent manner. Sub-family also includes eleven-nineteen-leukemia protein ENL, which binds histones H3 and H1. DNA regulation by chromatin through histone post-translational modification and other mechanisms involves complexes with write, eraser and reader functions. YEATS domains act as readers of the chromatin state and stimulates transcriptional activity through preferential interactions with crotonylated lysines on histones. The YEATS family is named for several family members: 'YNK7', 'ENL', 'AF-9', and 'TFIIF small subunit', and also contains the GAS41 protein.


Pssm-ID: 341125  Cd Length: 127  Bit Score: 93.02  E-value: 3.84e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026919863  22 GNKARYFGQTRDDGFTHEWTVYVKPYFDEDVSKYIKKVHFKLHESYQNSVRVINEPPFQVNEAGWGEFDIHIRIYFTETT 101
Cdd:cd16906     6 GHSATLRKKPTPEGHTHDWTVFVRGANGSDISHFVEKVVFHLHESFPKPKRVVKEPPFEVTESGYAGFTLPIEIYFKNKE 85

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1026919863 102 E-KAVSFVHHLTLFPPGQQRIFTsgLHKYEF 131
Cdd:cd16906    86 EpKKVRFEYDLFLHLGPPVNHLR--TEKLTF 114
YEATS_Taf14_like cd16905
YEATS domain found in Taf14 and similar proteins; Taf14 has been identified as a component of ...
 29-112 2.69e-14

YEATS domain found in Taf14 and similar proteins; Taf14 has been identified as a component of TFIIF and TFIID transcription factor complexes, various chromatin-remodeling complexes (such as SWI/SNF, INO80, and RSC) and the NuA3 histone acetyltransferase complex. DNA regulation by chromatin thru histone post-translational modification and other mechanism involves complexes with write, eraser and reader functions. YEATS domains act as readers of the chromatin state, and stimulate transcriptional activity, thru preferential interactions with crotonylated lysines on histones. Specifically, Taf14 has been show to be a reader of lysine crotonylation, associated with active gene promoters and enhancers and binding acetyllysine on in histone H3. The YEATS family is named for several family members: 'YNK7', 'ENL', 'AF-9', and 'TFIIF small subunit', and also contains the GAS41 protein.


Pssm-ID: 341124  Cd Length: 118  Bit Score: 66.82  E-value: 2.69e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026919863  29 GQTRDDGF-THEWTVYV---KPYFDEDVSKYIKKVHFKLHESYQNSVRVINEPPFQVNEAGWGEFDIHIRIYFTETTEKa 104
Cdd:cd16905    16 DVPPVEGFpLRKWSIELvllDPNGEEVPADIFDKVTYHLHPTFENPIRTFKKPPFRLEEKGWGEFDMKIVLHFLDNGGE- 94


                  ....*...
gi 1026919863 105 VSFVHHLT 112
Cdd:cd16905    95 FTITHDLN 102
pYEATS pfam20305
prokaryotic YEATS domain; This entry represents a prokaryotic YEATS domain. pYEATS is fused to ...
 39-107 4.52e-10

prokaryotic YEATS domain; This entry represents a prokaryotic YEATS domain. pYEATS is fused to diverse effector domains, suggesting that the binding to a ligand activates an effector-based response against an invasive threat. It has been predicted to specifically recognize invader-induced modifications of macromolecules by acyl moieties (e.g. phage-encoded acylations of surface polysaccharides) to unleash the fused effectors through a conformational change.


Pssm-ID: 466455  Cd Length: 73  Bit Score: 54.21  E-value: 4.52e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1026919863  39 EWTVYVKPyfDEDVSKYIKKVHFKLHESYQNSVRVINEP--PFQVNEAGWGEFDIHIRIYFTETTEKAVSF 107
Cdd:pfam20305   2 DVRLWVDG--PDPVLLLIESVEYTLHPTFPNPVRTVTDRngNFSLSLSAWGAFTVGAEVEFKDGGEIELER 70
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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