|
Name |
Accession |
Description |
Interval |
E-value |
| HrpA |
COG1643 |
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]; |
575-1138 |
6.48e-108 |
|
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
Pssm-ID: 441249 [Multi-domain] Cd Length: 836 Bit Score: 360.94 E-value: 6.48e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 575 EKLPAWESRRKIMDAIQHSQVVVISGETGSGKSTQVVQFILDHYLSSGekdlQTVVCTQPRRISAISLAERVAFERDTTV 654
Cdd:COG1643 8 PDLPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALLELGWGAG----GRIGMLEPRRLAARAAAERMAEELGEPV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 655 GKEVGYSVHGEKSISKETLLEFCTTGLLLRRIQQHglGFLSTLSCVVVDEVHERSIENDILLTLLKLVISRI-PNLKVIL 733
Cdd:COG1643 84 GETVGYRVRFEDKVSAATRIEVVTEGILLRELQRD--PELEGVDTVIFDEFHERSLNADLLLALLLDLQPALrPDLKLLV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 734 MSATVNSDTFKYYFGNAGHLHIHGRTFPIKDYYiedfAPKLNEDDDEEDvprrkkkeyeidyhlisRLVSSIDAELGSSS 813
Cdd:COG1643 162 MSATLDAERFARLLGDAPVIESSGRTYPVEVRY----RPLPADERDLED-----------------AVADAVREALAEEP 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 814 GSILVFLPGVSNIARCIREIKSKDGSKFEVLPLHASLNTSEQRRCFKTYT--KRKIICATNIAETSITIDDVVAVIDSG- 890
Cdd:COG1643 221 GDILVFLPGEREIRRTAEALRGRLPPDTEILPLYGRLSAAEQDRAFAPAPhgRRRIVLATNIAETSLTVPGIRYVIDSGl 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 891 -RVKQIDYD--VERdLVTFKetwASRAACQQRRGRAGRVKKGICYKLYTRGfEEKGMLGQTPPEVLRTALSQVCLnvvpl 967
Cdd:COG1643 301 aRIPRYDPRsgVTR-LPTER---ISQASANQRAGRAGRLAPGICYRLWSEE-DFARRPAFTDPEILRADLASLIL----- 370
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 968 vkRFSSAGNsvnqGSIKKFmnSLIDPPNDATVDLALKKLIQVGALTVSEDLTGLGEYLVSLPIDLKLGKLLVFGSIFGYL 1047
Cdd:COG1643 371 --ELAAWGL----GDPEDL--PFLDPPPARAIADARALLQELGALDADGRLTPLGRALARLPLDPRLARMLLAAAELGCL 442
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 1048 EPALTITAILSTKSPFLGDDEAreirskqsqgwgDVLAdarvyhnWLEILETRGVKKtvqwceEMHLHYTTLQQIRQnrn 1127
Cdd:COG1643 443 REAAILAALLSERDPRRGAAGS------------DLLA-------RLNLWRRLREQQ------REFLSYLRLREWRD--- 494
|
570
....*....|.
gi 74582920 1128 elsEAAQLLEL 1138
Cdd:COG1643 495 ---LARQLRRL 502
|
|
| PRK11131 |
PRK11131 |
ATP-dependent RNA helicase HrpA; Provisional |
566-1145 |
2.77e-79 |
|
ATP-dependent RNA helicase HrpA; Provisional
Pssm-ID: 182986 [Multi-domain] Cd Length: 1294 Bit Score: 286.96 E-value: 2.77e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 566 SYQLKVREREKLPAWESRRKIMDAIQHSQVVVISGETGSGKSTQVVQFILDhyLSSGEKDLqtVVCTQPRRISAISLAER 645
Cdd:PRK11131 62 AARPEITYPENLPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICLE--LGRGVKGL--IGHTQPRRLAARTVANR 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 646 VAFERDTTVGKEVGYSVHGEKSISKETLLEFCTTGLLLRRIQQHGlgFLSTLSCVVVDEVHERSIENDILLTLLKLVISR 725
Cdd:PRK11131 138 IAEELETELGGCVGYKVRFNDQVSDNTMVKLMTDGILLAEIQQDR--LLMQYDTIIIDEAHERSLNIDFILGYLKELLPR 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 726 IPNLKVILMSATVNSDTFKYYFGNAGHLHIHGRTFPIKDYYiedfAPKLNEDDDEEDvprrkkkeyeidyhliSRLVSSI 805
Cdd:PRK11131 216 RPDLKVIITSATIDPERFSRHFNNAPIIEVSGRTYPVEVRY----RPIVEEADDTER----------------DQLQAIF 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 806 DA--ELGS-SSGSILVFLPGvsniARCIRE----IKSKDGSKFEVLPLHASLNTSEQRRCFKTYTKRKIICATNIAETSI 878
Cdd:PRK11131 276 DAvdELGReGPGDILIFMSG----EREIRDtadaLNKLNLRHTEILPLYARLSNSEQNRVFQSHSGRRIVLATNVAETSL 351
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 879 TIDDVVAVIDSG--RVKQIDY--DVERDLVtfkETwASRAACQQRRGRAGRVKKGICYKLYTrgfeEKGMLGQ---TPPE 951
Cdd:PRK11131 352 TVPGIKYVIDPGtaRISRYSYrtKVQRLPI---EP-ISQASANQRKGRCGRVSEGICIRLYS----EDDFLSRpefTDPE 423
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 952 VLRTALSQVCLNVVPLvkrfssagnsvNQGSIKKFmnSLIDPPNDATVDLALKKLIQVGALTVSED-----LTGLGEYLV 1026
Cdd:PRK11131 424 ILRTNLASVILQMTAL-----------GLGDIAAF--PFVEAPDKRNIQDGVRLLEELGAITTDEQasaykLTPLGRQLA 490
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 1027 SLPIDLKLGKLLVFGSIFGYLEPALTITAILSTKSPF--------LGDDEAREIRSKQSqgwgDVLADARVYhNWLEilE 1098
Cdd:PRK11131 491 QLPVDPRLARMVLEAQKHGCVREVMIITSALSIQDPRerpmdkqqASDEKHRRFADKES----DFLAFVNLW-NYLQ--E 563
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 74582920 1099 TRGVKKTVQW---CEEMHLHYTTL-------QQIRQNRNEL-----SEAAQLLELTTKKLTG 1145
Cdd:PRK11131 564 QQKALSSNQFrrlCRTDYLNYLRVrewqdiyTQLRQVVKELgipvnSEPAEYREIHTALLTG 625
|
|
| DEXHc_RHA-like |
cd17917 |
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) ... |
594-755 |
7.21e-78 |
|
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438707 [Multi-domain] Cd Length: 159 Bit Score: 253.54 E-value: 7.21e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 594 QVVVISGETGSGKSTQVVQFILDHYLSSGEKDLqtVVCTQPRRISAISLAERVAFERDTTVGKEVGYSVHGEKSISKETL 673
Cdd:cd17917 2 QVVVIVGETGSGKTTQVPQFLLEDGLAKGGKGR--IVCTQPRRIAAISVAERVAEERGEKLGEEVGYQIRFESKTSSKTR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 674 LEFCTTGLLLRRIQQHGLgfLSTLSCVVVDEVHERSIENDILLTLLKLVISRIPNLKVILMSATVNSDTFKYYFGNAGHL 753
Cdd:cd17917 80 IKFCTDGILLRELLSDPL--LSGYSHVILDEAHERSLDTDFLLGLLKDLLRKRPDLKVILMSATLDAEKFSSYFGGAPVI 157
|
..
gi 74582920 754 HI 755
Cdd:cd17917 158 HI 159
|
|
| DEAH_box_HrpB |
TIGR01970 |
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but ... |
577-1101 |
4.43e-70 |
|
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria, but also in a few species of other lineages. The member from Rhizobium meliloti has been designated HelO. HrpB is typically about 800 residues in length, while its paralog HrpA (TIGR01967), also uncharacterized, is about 1300 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 273901 [Multi-domain] Cd Length: 819 Bit Score: 252.76 E-value: 4.43e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 577 LPAWESRRKIMDAIQHSQVVVISGETGSGKSTQVVQFILDHYLSSGEkdlqtVVCTQPRRISAISLAERVAFERDTTVGK 656
Cdd:TIGR01970 1 LPIHAVLPALRDALAAHPQVVLEAPPGAGKSTAVPLALLDAPGIGGK-----IIMLEPRRLAARSAAQRLASQLGEAVGQ 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 657 EVGYSVHGEKSISKETLLEFCTTGLLLRRIQQHGLgfLSTLSCVVVDEVHERSIENDILLTLLKLVISRI-PNLKVILMS 735
Cdd:TIGR01970 76 TVGYRVRGENKVSRRTRLEVVTEGILTRMIQDDPE--LDGVGALIFDEFHERSLDADLGLALALDVQSSLrEDLKILAMS 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 736 ATVNSDTFKYYFGNAGHLHIHGRTFPIKDYYIedfapklnedddeedvPRRKkkeyeiDYHLISRLVSSIDAELGSSSGS 815
Cdd:TIGR01970 154 ATLDGERLSSLLPDAPVVESEGRSFPVEIRYL----------------PLRG------DQRLEDAVSRAVEHALASETGS 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 816 ILVFLPGVSNIARCIREIKSKDGSKFEVLPLHASLNTSEQRRCFKTYTK--RKIICATNIAETSITIDDVVAVIDSGRVK 893
Cdd:TIGR01970 212 ILVFLPGQAEIRRVQEQLAERLDSDVLICPLYGELSLAAQDRAIKPDPQgrRKVVLATNIAETSLTIEGIRVVIDSGLAR 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 894 QIDYDVERDLVTFKETWASRAACQQRRGRAGRVKKGICYKLYTRGfEEKGMLGQTPPEVLRTALSQVCLNVVPL-VKRFS 972
Cdd:TIGR01970 292 VARFDPKTGITRLETVRISQASATQRAGRAGRLEPGVCYRLWSEE-QHQRLPAQDEPEILQADLSGLALELAQWgAKDPS 370
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 973 SAgnsvnqgsikkfmnSLIDPPNDATVDLALKKLIQVGALTVSEDLTGLGEYLVSLPIDLKLGKLLVFGSIFGYLEPALT 1052
Cdd:TIGR01970 371 DL--------------RWLDAPPSVALAAARQLLQRLGALDAQGRLTAHGKAMAALGCHPRLAAMLLSAHSTGLAALACD 436
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|
gi 74582920 1053 ITAILSTKS-PFLGDDEAREIRSKQSQGWGDVLADARvyhNWLEILETRG 1101
Cdd:TIGR01970 437 LAALLEERGlPRQGGADLMNRLHRLQQGRQGRGQRAQ---QLAKKLRRRL 483
|
|
| RWD_YLR419W-like |
cd23827 |
RWD domain of Saccharomyces cerevisiae putative ATP-dependent RNA helicase YLR419W and related ... |
403-505 |
1.91e-33 |
|
RWD domain of Saccharomyces cerevisiae putative ATP-dependent RNA helicase YLR419W and related proteins; YLR419W (EC 3.6.4.13) may act as an ATP-binding RNA helicase. The RWD domain may mediate protein-protein interactions.
Pssm-ID: 467662 Cd Length: 104 Bit Score: 124.67 E-value: 1.91e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 403 WDDDVSALQSILDNKVSKIE-NGCRVRIDYPTSEFGELFVDFRRPArSYPAHIPLMSLSSTKRMASYIKLSILKKMVVYA 481
Cdd:cd23827 1 WDEEIEALEAIYGEKFEVISdDSCEITLNSPTKTKPSLKLKFYKSS-SYPNSLPGIFISSSDKLPAYIKLAIIRQLLQYA 79
|
90 100
....*....|....*....|....*
gi 74582920 482 MD-LRGECMLSWLYNHLQENIEDFL 505
Cdd:cd23827 80 RDnLLGDPMIFSIVEWLEENIEEII 104
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
589-750 |
2.56e-20 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 90.63 E-value: 2.56e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 589 AIQHSQVVVISGETGSGKSTQVVQFILDHYLSSGEKdlqTVVCTQPRRISAISLAERVAFERDTTVGKEVGYsVHGEKSI 668
Cdd:smart00487 20 LLSGLRDVILAAPTGSGKTLAALLPALEALKRGKGG---RVLVLVPTRELAEQWAEELKKLGPSLGLKVVGL-YGGDSKR 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 669 SKETLLE-------FCTTGLLLRRIQQHGLgFLSTLSCVVVDEVHERSIEN--DILLTLLKLVisrIPNLKVILMSATVN 739
Cdd:smart00487 96 EQLRKLEsgktdilVTTPGRLLDLLENDKL-SLSNVDLVILDEAHRLLDGGfgDQLEKLLKLL---PKNVQLLLLSATPP 171
|
170
....*....|...
gi 74582920 740 SDT--FKYYFGNA 750
Cdd:smart00487 172 EEIenLLELFLND 184
|
|
| RWD |
smart00591 |
domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily ... |
406-504 |
6.30e-16 |
|
domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain;
Pssm-ID: 214735 Cd Length: 107 Bit Score: 74.70 E-value: 6.30e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 406 DVSALQSILDNKVSKIEN---GCRVRIDYPTSEFG------ELFVDFRRPArSYPAHIPLMSLSSTKRMASYIKLSILKK 476
Cdd:smart00591 1 ELEALESIYPEDFEVIDEdarIPEITIKLSPSSDEgedqyvSLTLQVKLPE-NYPDEAPPISLLNSEGLSDEQLAELLKK 79
|
90 100
....*....|....*....|....*...
gi 74582920 477 MVVYAMDLRGECMLSWLYNHLQENIEDF 504
Cdd:smart00591 80 LEEIAEENLGEVMIFELVEKLQEFLSEF 107
|
|
| HA2 |
pfam04408 |
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ... |
1002-1078 |
7.44e-15 |
|
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 461295 [Multi-domain] Cd Length: 104 Bit Score: 71.50 E-value: 7.44e-15
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 74582920 1002 ALKKLIQVGALTVSEDLTGLGEYLVSLPIDLKLGKLLVFGSIFGYLEPALTITAILSTKSPFLGDDEAREIRSKQSQ 1078
Cdd:pfam04408 1 ALELLYYLGALDEDGELTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRDPFVQPNFLDPRSAAKAA 77
|
|
| OB_NTP_bind |
pfam07717 |
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ... |
1158-1258 |
1.88e-13 |
|
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.
Pssm-ID: 400182 [Multi-domain] Cd Length: 82 Bit Score: 66.89 E-value: 1.88e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 1158 LSTLIAAALSPNVVKCVYPDKKFVASFsgslemeqearltkfydqNNQRLFIHPSSTMFvnSPNASRCTFVAYEQKVETT 1237
Cdd:pfam07717 1 LRAALAAGLYPNVARRDPKGKGYTTLS------------------DNQRVFIHPSSVLF--NEKTFPPEWVVYQELVETT 60
|
90 100
....*....|....*....|.
gi 74582920 1238 KPFLRNCTPINTYGMILLGAN 1258
Cdd:pfam07717 61 KVYIRTVTAISPEWLLLFAPH 81
|
|
| RWD |
pfam05773 |
RWD domain; This domain was identified in WD40 repeat proteins and Ring finger domain proteins. ... |
402-501 |
2.71e-09 |
|
RWD domain; This domain was identified in WD40 repeat proteins and Ring finger domain proteins. The function of this domain is unknown. GCN2 is the alpha-subunit of the only translation initiation factor (eIF2 alpha) kinase that appears in all eukaryotes. Its function requires an interaction with GCN1 via the domain at its N-terminus, which is termed the RWD domain after three major RWD-containing proteins: RING finger-containing proteins, WD-repeat-containing proteins, and yeast DEAD (DEXD)-like helicases. The structure forms an alpha + beta sandwich fold consisting of two layers: a four-stranded antiparallel beta-sheet, and three side-by-side alpha-helices.
Pssm-ID: 399058 Cd Length: 111 Bit Score: 56.18 E-value: 2.71e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 402 EWDDDVSALQSILDNKVSKIENGC------RVRID-----YPTSEFGELFVDFRRPArSYPAHIPLMSLSSTKRMASYIK 470
Cdd:pfam05773 2 EQEEELEALESIYPDEFEVISDSPyesleiEIKLSldsdeSDSSHLPPLVLKFTLPE-DYPDEPPKISLSSPWNLSDEQV 80
|
90 100 110
....*....|....*....|....*....|.
gi 74582920 471 LSILKKMVVYAMDLRGECMLSWLYNHLQENI 501
Cdd:pfam05773 81 LSLLEELEELAEENLGEVMIFELIEWLQENL 111
|
|
| UBA |
pfam00627 |
UBA/TS-N domain; This small domain is composed of three alpha helices. This family includes ... |
277-312 |
6.37e-04 |
|
UBA/TS-N domain; This small domain is composed of three alpha helices. This family includes the previously defined UBA and TS-N domains. The UBA-domain (ubiquitin associated domain) is a novel sequence motif found in several proteins having connections to ubiquitin and the ubiquitination pathway. The structure of the UBA domain consists of a compact three helix bundle. This domain is found at the N terminus of EF-TS hence the name TS-N. The structure of EF-TS is known and this domain is implicated in its interaction with EF-TU. The domain has been found in non EF-TS proteins such as alpha-NAC and MJ0280.
Pssm-ID: 395502 [Multi-domain] Cd Length: 37 Bit Score: 38.58 E-value: 6.37e-04
10 20 30
....*....|....*....|....*....|....*..
gi 74582920 277 PDTSIVNDLISLGFRDIHAKEACQYCV-SLEDALEWL 312
Cdd:pfam00627 1 EDEEAIQRLVEMGFDREQVREALRATGnNVERAAEYL 37
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| HrpA |
COG1643 |
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]; |
575-1138 |
6.48e-108 |
|
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
Pssm-ID: 441249 [Multi-domain] Cd Length: 836 Bit Score: 360.94 E-value: 6.48e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 575 EKLPAWESRRKIMDAIQHSQVVVISGETGSGKSTQVVQFILDHYLSSGekdlQTVVCTQPRRISAISLAERVAFERDTTV 654
Cdd:COG1643 8 PDLPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALLELGWGAG----GRIGMLEPRRLAARAAAERMAEELGEPV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 655 GKEVGYSVHGEKSISKETLLEFCTTGLLLRRIQQHglGFLSTLSCVVVDEVHERSIENDILLTLLKLVISRI-PNLKVIL 733
Cdd:COG1643 84 GETVGYRVRFEDKVSAATRIEVVTEGILLRELQRD--PELEGVDTVIFDEFHERSLNADLLLALLLDLQPALrPDLKLLV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 734 MSATVNSDTFKYYFGNAGHLHIHGRTFPIKDYYiedfAPKLNEDDDEEDvprrkkkeyeidyhlisRLVSSIDAELGSSS 813
Cdd:COG1643 162 MSATLDAERFARLLGDAPVIESSGRTYPVEVRY----RPLPADERDLED-----------------AVADAVREALAEEP 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 814 GSILVFLPGVSNIARCIREIKSKDGSKFEVLPLHASLNTSEQRRCFKTYT--KRKIICATNIAETSITIDDVVAVIDSG- 890
Cdd:COG1643 221 GDILVFLPGEREIRRTAEALRGRLPPDTEILPLYGRLSAAEQDRAFAPAPhgRRRIVLATNIAETSLTVPGIRYVIDSGl 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 891 -RVKQIDYD--VERdLVTFKetwASRAACQQRRGRAGRVKKGICYKLYTRGfEEKGMLGQTPPEVLRTALSQVCLnvvpl 967
Cdd:COG1643 301 aRIPRYDPRsgVTR-LPTER---ISQASANQRAGRAGRLAPGICYRLWSEE-DFARRPAFTDPEILRADLASLIL----- 370
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 968 vkRFSSAGNsvnqGSIKKFmnSLIDPPNDATVDLALKKLIQVGALTVSEDLTGLGEYLVSLPIDLKLGKLLVFGSIFGYL 1047
Cdd:COG1643 371 --ELAAWGL----GDPEDL--PFLDPPPARAIADARALLQELGALDADGRLTPLGRALARLPLDPRLARMLLAAAELGCL 442
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 1048 EPALTITAILSTKSPFLGDDEAreirskqsqgwgDVLAdarvyhnWLEILETRGVKKtvqwceEMHLHYTTLQQIRQnrn 1127
Cdd:COG1643 443 REAAILAALLSERDPRRGAAGS------------DLLA-------RLNLWRRLREQQ------REFLSYLRLREWRD--- 494
|
570
....*....|.
gi 74582920 1128 elsEAAQLLEL 1138
Cdd:COG1643 495 ---LARQLRRL 502
|
|
| PRK11131 |
PRK11131 |
ATP-dependent RNA helicase HrpA; Provisional |
566-1145 |
2.77e-79 |
|
ATP-dependent RNA helicase HrpA; Provisional
Pssm-ID: 182986 [Multi-domain] Cd Length: 1294 Bit Score: 286.96 E-value: 2.77e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 566 SYQLKVREREKLPAWESRRKIMDAIQHSQVVVISGETGSGKSTQVVQFILDhyLSSGEKDLqtVVCTQPRRISAISLAER 645
Cdd:PRK11131 62 AARPEITYPENLPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICLE--LGRGVKGL--IGHTQPRRLAARTVANR 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 646 VAFERDTTVGKEVGYSVHGEKSISKETLLEFCTTGLLLRRIQQHGlgFLSTLSCVVVDEVHERSIENDILLTLLKLVISR 725
Cdd:PRK11131 138 IAEELETELGGCVGYKVRFNDQVSDNTMVKLMTDGILLAEIQQDR--LLMQYDTIIIDEAHERSLNIDFILGYLKELLPR 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 726 IPNLKVILMSATVNSDTFKYYFGNAGHLHIHGRTFPIKDYYiedfAPKLNEDDDEEDvprrkkkeyeidyhliSRLVSSI 805
Cdd:PRK11131 216 RPDLKVIITSATIDPERFSRHFNNAPIIEVSGRTYPVEVRY----RPIVEEADDTER----------------DQLQAIF 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 806 DA--ELGS-SSGSILVFLPGvsniARCIRE----IKSKDGSKFEVLPLHASLNTSEQRRCFKTYTKRKIICATNIAETSI 878
Cdd:PRK11131 276 DAvdELGReGPGDILIFMSG----EREIRDtadaLNKLNLRHTEILPLYARLSNSEQNRVFQSHSGRRIVLATNVAETSL 351
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 879 TIDDVVAVIDSG--RVKQIDY--DVERDLVtfkETwASRAACQQRRGRAGRVKKGICYKLYTrgfeEKGMLGQ---TPPE 951
Cdd:PRK11131 352 TVPGIKYVIDPGtaRISRYSYrtKVQRLPI---EP-ISQASANQRKGRCGRVSEGICIRLYS----EDDFLSRpefTDPE 423
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 952 VLRTALSQVCLNVVPLvkrfssagnsvNQGSIKKFmnSLIDPPNDATVDLALKKLIQVGALTVSED-----LTGLGEYLV 1026
Cdd:PRK11131 424 ILRTNLASVILQMTAL-----------GLGDIAAF--PFVEAPDKRNIQDGVRLLEELGAITTDEQasaykLTPLGRQLA 490
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 1027 SLPIDLKLGKLLVFGSIFGYLEPALTITAILSTKSPF--------LGDDEAREIRSKQSqgwgDVLADARVYhNWLEilE 1098
Cdd:PRK11131 491 QLPVDPRLARMVLEAQKHGCVREVMIITSALSIQDPRerpmdkqqASDEKHRRFADKES----DFLAFVNLW-NYLQ--E 563
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 74582920 1099 TRGVKKTVQW---CEEMHLHYTTL-------QQIRQNRNEL-----SEAAQLLELTTKKLTG 1145
Cdd:PRK11131 564 QQKALSSNQFrrlCRTDYLNYLRVrewqdiyTQLRQVVKELgipvnSEPAEYREIHTALLTG 625
|
|
| DEXHc_RHA-like |
cd17917 |
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) ... |
594-755 |
7.21e-78 |
|
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438707 [Multi-domain] Cd Length: 159 Bit Score: 253.54 E-value: 7.21e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 594 QVVVISGETGSGKSTQVVQFILDHYLSSGEKDLqtVVCTQPRRISAISLAERVAFERDTTVGKEVGYSVHGEKSISKETL 673
Cdd:cd17917 2 QVVVIVGETGSGKTTQVPQFLLEDGLAKGGKGR--IVCTQPRRIAAISVAERVAEERGEKLGEEVGYQIRFESKTSSKTR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 674 LEFCTTGLLLRRIQQHGLgfLSTLSCVVVDEVHERSIENDILLTLLKLVISRIPNLKVILMSATVNSDTFKYYFGNAGHL 753
Cdd:cd17917 80 IKFCTDGILLRELLSDPL--LSGYSHVILDEAHERSLDTDFLLGLLKDLLRKRPDLKVILMSATLDAEKFSSYFGGAPVI 157
|
..
gi 74582920 754 HI 755
Cdd:cd17917 158 HI 159
|
|
| DEAH_box_HrpB |
TIGR01970 |
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but ... |
577-1101 |
4.43e-70 |
|
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria, but also in a few species of other lineages. The member from Rhizobium meliloti has been designated HelO. HrpB is typically about 800 residues in length, while its paralog HrpA (TIGR01967), also uncharacterized, is about 1300 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 273901 [Multi-domain] Cd Length: 819 Bit Score: 252.76 E-value: 4.43e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 577 LPAWESRRKIMDAIQHSQVVVISGETGSGKSTQVVQFILDHYLSSGEkdlqtVVCTQPRRISAISLAERVAFERDTTVGK 656
Cdd:TIGR01970 1 LPIHAVLPALRDALAAHPQVVLEAPPGAGKSTAVPLALLDAPGIGGK-----IIMLEPRRLAARSAAQRLASQLGEAVGQ 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 657 EVGYSVHGEKSISKETLLEFCTTGLLLRRIQQHGLgfLSTLSCVVVDEVHERSIENDILLTLLKLVISRI-PNLKVILMS 735
Cdd:TIGR01970 76 TVGYRVRGENKVSRRTRLEVVTEGILTRMIQDDPE--LDGVGALIFDEFHERSLDADLGLALALDVQSSLrEDLKILAMS 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 736 ATVNSDTFKYYFGNAGHLHIHGRTFPIKDYYIedfapklnedddeedvPRRKkkeyeiDYHLISRLVSSIDAELGSSSGS 815
Cdd:TIGR01970 154 ATLDGERLSSLLPDAPVVESEGRSFPVEIRYL----------------PLRG------DQRLEDAVSRAVEHALASETGS 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 816 ILVFLPGVSNIARCIREIKSKDGSKFEVLPLHASLNTSEQRRCFKTYTK--RKIICATNIAETSITIDDVVAVIDSGRVK 893
Cdd:TIGR01970 212 ILVFLPGQAEIRRVQEQLAERLDSDVLICPLYGELSLAAQDRAIKPDPQgrRKVVLATNIAETSLTIEGIRVVIDSGLAR 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 894 QIDYDVERDLVTFKETWASRAACQQRRGRAGRVKKGICYKLYTRGfEEKGMLGQTPPEVLRTALSQVCLNVVPL-VKRFS 972
Cdd:TIGR01970 292 VARFDPKTGITRLETVRISQASATQRAGRAGRLEPGVCYRLWSEE-QHQRLPAQDEPEILQADLSGLALELAQWgAKDPS 370
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 973 SAgnsvnqgsikkfmnSLIDPPNDATVDLALKKLIQVGALTVSEDLTGLGEYLVSLPIDLKLGKLLVFGSIFGYLEPALT 1052
Cdd:TIGR01970 371 DL--------------RWLDAPPSVALAAARQLLQRLGALDAQGRLTAHGKAMAALGCHPRLAAMLLSAHSTGLAALACD 436
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|
gi 74582920 1053 ITAILSTKS-PFLGDDEAREIRSKQSQGWGDVLADARvyhNWLEILETRG 1101
Cdd:TIGR01970 437 LAALLEERGlPRQGGADLMNRLHRLQQGRQGRGQRAQ---QLAKKLRRRL 483
|
|
| SF2_C_RHA |
cd18791 |
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ... |
760-935 |
2.56e-64 |
|
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350178 [Multi-domain] Cd Length: 171 Bit Score: 215.48 E-value: 2.56e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 760 FPIKDYYIEDFAPKLNEDDDEEDvprrkkkeyEIDYHLISRLVSSIDAELGSssGSILVFLPGVSNIARCIREIK----S 835
Cdd:cd18791 1 FPVEVYYLEDILELLGISSEKED---------PDYVDAAVRLILQIHRTEEP--GDILVFLPGQEEIERLCELLReellS 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 836 KDGSKFEVLPLHASLNTSEQRRCFKTY--TKRKIICATNIAETSITIDDVVAVIDSGRVKQIDYDVERDLVTFKETWASR 913
Cdd:cd18791 70 PDLGKLLVLPLHSSLPPEEQQRVFEPPppGVRKVVLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWISK 149
|
170 180
....*....|....*....|..
gi 74582920 914 AACQQRRGRAGRVKKGICYKLY 935
Cdd:cd18791 150 ASAEQRAGRAGRTRPGKCYRLY 171
|
|
| DEXHc_DHX57 |
cd17985 |
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the ... |
577-755 |
6.26e-59 |
|
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350743 [Multi-domain] Cd Length: 177 Bit Score: 200.45 E-value: 6.26e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 577 LPAWESRRKIMDAIQHSQVVVISGETGSGKSTQVVQFILDHYLSSGEKDLQTVVCTQPRRISAISLAERVAFERDTTVGK 656
Cdd:cd17985 1 LPAWQERETILELLEKHQVLVISGMTGCGKTTQIPQFILDNSLQGPPLPVANIICTQPRRISAISVAERVAQERAERVGQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 657 EVGYSVHGEKSISKETLLEFCTTGLLLRRIQqhGLGFLSTLSCVVVDEVHERSIENDILLTLLKLVISRIPNLKVILMSA 736
Cdd:cd17985 81 SVGYQIRLESVKSSATRLLYCTTGVLLRRLE--GDPTLQGVTHVIVDEVHERTEESDFLLLVLKDLMVQRPDLKVILMSA 158
|
170
....*....|....*....
gi 74582920 737 TVNSDTFKYYFGNAGHLHI 755
Cdd:cd17985 159 TLNAELFSDYFNSCPVIHI 177
|
|
| DEXHc_DHX36 |
cd17981 |
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as ... |
577-755 |
1.82e-54 |
|
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as G4-resolvase 1 or G4R1, MLE-like protein 1 and RNA helicase associated with AU-rich element or RHAU) unwinds a G4-quadruplex in human telomerase RNA. DHX36 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350739 [Multi-domain] Cd Length: 180 Bit Score: 187.74 E-value: 1.82e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 577 LPAWESRRKIMDAIQHSQVVVISGETGSGKSTQVVQFILDHYLSSGEKDLQTVVCTQPRRISAISLAERVAFER--DTTV 654
Cdd:cd17981 1 LPSYGMKQEIINMIDNNQVTVISGETGCGKTTQVTQFILDDAIERGKGSSCRIVCTQPRRISAISVAERVAAERaeSCGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 655 GKEVGYSVHGE-KSISKETLLEFCTTGLLLRRIQQHGLgfLSTLSCVVVDEVHERSIENDILLTLLKLVISRIPNLKVIL 733
Cdd:cd17981 81 GNSTGYQIRLEsRKPRKQGSILYCTTGIVLQWLQSDPH--LSNVSHLVLDEIHERNLQSDVLMGIVKDLLPFRSDLKVIL 158
|
170 180
....*....|....*....|..
gi 74582920 734 MSATVNSDTFKYYFGNAGHLHI 755
Cdd:cd17981 159 MSATLNAEKFSDYFNNCPMIHI 180
|
|
| DEXHc_DHX9 |
cd17972 |
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ... |
541-749 |
3.43e-54 |
|
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ATP-dependent RNA helicase A or RHA and leukophysin or LKP) plays an important role in many cellular processes, including regulation of DNA replication, transcription, translation, microRNA biogenesis, RNA processing and transport, and maintenance of genomic stability. DHX9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350730 [Multi-domain] Cd Length: 234 Bit Score: 189.27 E-value: 3.43e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 541 PKLFRRSRELSEKLCNNWS-ERVKSPSYQLKVREREKLPAWESRRKIMDAIQHSQVVVISGETGSGKSTQVVQFILDHYL 619
Cdd:cd17972 22 PLAFATPEQISMDLKNELMyQREQDHNLQQILQERELLPVKKFREEILEAISNNPVVIIRGATGCGKTTQVPQYILDDFI 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 620 SSGEKDLQTVVCTQPRRISAISLAERVAFERDTTVGKEVGYSVHGEKSISK-ETLLEFCTTGLLLRRIQQHglgfLSTLS 698
Cdd:cd17972 102 QNDRAAECNIVVTQPRRISAVSVAERVAFERGEEVGKSCGYSVRFESVLPRpHASILFCTVGVLLRKLEAG----IRGIS 177
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 74582920 699 CVVVDEVHERSIENDILLTLLKLVISRIPNLKVILMSATVNSDTFKYYFGN 749
Cdd:cd17972 178 HVIVDEIHERDINTDFLLVVLRDVVQAYPDLRVILMSATIDTSMFCEYFFN 228
|
|
| PRK11664 |
PRK11664 |
ATP-dependent RNA helicase HrpB; Provisional |
586-1057 |
1.13e-53 |
|
ATP-dependent RNA helicase HrpB; Provisional
Pssm-ID: 236950 [Multi-domain] Cd Length: 812 Bit Score: 202.85 E-value: 1.13e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 586 IMDAIQHSQVVVISGETGSGKSTQVVQFILDHYLSSGEkdlqtVVCTQPRRISAISLAERVAFERDTTVGKEVGYSVHGE 665
Cdd:PRK11664 13 LLTALKTAPQVLLKAPTGAGKSTWLPLQLLQHGGINGK-----IIMLEPRRLAARNVAQRLAEQLGEKPGETVGYRMRAE 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 666 KSISKETLLEFCTTGLLLRRIQQHGLgfLSTLSCVVVDEVHERSIENDILLTLLKLVISRI-PNLKVILMSATVNSDTFK 744
Cdd:PRK11664 88 SKVGPNTRLEVVTEGILTRMIQRDPE--LSGVGLVILDEFHERSLQADLALALLLDVQQGLrDDLKLLIMSATLDNDRLQ 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 745 YYFGNAGHLHIHGRTFPIKDYYiedfAPKLNEDDDEEDVPRRkkkeyeidyhlISRLvssidaeLGSSSGSILVFLPGVS 824
Cdd:PRK11664 166 QLLPDAPVIVSEGRSFPVERRY----QPLPAHQRFDEAVARA-----------TAEL-------LRQESGSLLLFLPGVG 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 825 NIARCIREIKSKDGSKFEVLPLHASLNTSEQRRCFKTYT--KRKIICATNIAETSITIDDVVAVIDSG--RVKQidYDVE 900
Cdd:PRK11664 224 EIQRVQEQLASRVASDVLLCPLYGALSLAEQQKAILPAPagRRKVVLATNIAETSLTIEGIRLVVDSGleRVAR--FDPK 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 901 RDLVTFKETWASRAACQQRRGRAGRVKKGICYKLYTRGFEEKGMLgQTPPEVLRTALSqvclnvvPLVKRFSSAG-NSVN 979
Cdd:PRK11664 302 TGLTRLVTQRISQASMTQRAGRAGRLEPGICLHLYSKEQAERAAA-QSEPEILHSDLS-------GLLLELLQWGcHDPA 373
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 980 QgsikkfMNSLiDPPNDATVDLALKKLIQVGALTVSEDLTGLGEYLVSLPIDLKLGKLLVFGSIFG--YLEPALTITAIL 1057
Cdd:PRK11664 374 Q------LSWL-DQPPAAALAAAKRLLQQLGALDGQGRLTARGRKMAALGNDPRLAAMLVAAKEDDeaALATAAKLAAIL 446
|
|
| DEXHc_DHX15 |
cd17973 |
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA ... |
565-750 |
9.14e-53 |
|
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. DHX15 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438709 [Multi-domain] Cd Length: 187 Bit Score: 183.39 E-value: 9.14e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 565 PSYQLKVREREKLPAWESRRKIMDAIQHSQVVVISGETGSGKSTQVVQFILDHYLSSGEKDLqtVVCTQPRRISAISLAE 644
Cdd:cd17973 1 QRYFEILEKRRELPVWEQKEDFLKLLKNNQILVLVGETGSGKTTQIPQFVLDDELPHQPKKL--VACTQPRRVAAMSVAQ 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 645 RVAFERDTTVGKEVGYSVHGEKSISKETLLEFCTTGLLLRRIQQHGLgfLSTLSCVVVDEVHERSIENDILLTLLKLVIS 724
Cdd:cd17973 79 RVAEEMDVKLGEEVGYSIRFEDCSSAKTILKYMTDGMLLREAMSDPL--LSRYSVIILDEAHERTLATDILMGLLKEVVR 156
|
170 180
....*....|....*....|....*.
gi 74582920 725 RIPNLKVILMSATVNSDTFKYYFGNA 750
Cdd:cd17973 157 RRPDLKLIVMSATLDAGKFQKYFDNA 182
|
|
| DEXHc_YTHDC2 |
cd17987 |
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) ... |
577-755 |
1.04e-49 |
|
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) regulates mRNA translation and stability via binding to N6-methyladenosine, a modified RNA nucleotide enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. YTHDC2 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350745 [Multi-domain] Cd Length: 176 Bit Score: 173.86 E-value: 1.04e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 577 LPAWESRRKIMDAIQHSQVVVISGETGSGKSTQVVQFILDHYLSSGEKdlQTVVCTQPRRISAISLAERVAFERDTTVGK 656
Cdd:cd17987 1 LPVFEKQEQIVRIIKENKVVLIVGETGSGKTTQIPQFLLDDCYANGIP--CRIFCTQPRRLAAIAVAERVAAERGEKIGQ 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 657 EVGYSVHGEKSISKETLLEFCTTGLLLRRIQQhGLGFLSTLSCVVVDEVHERSIENDILLTLLKLVISRIPNLKVILMSA 736
Cdd:cd17987 79 TVGYQIRLESRVSPKTLLTFCTNGVLLRTLMA-GDSALSTVTHVIVDEVHERDRFSDFLLTKLRDILQKHPNLKLILSSA 157
|
170
....*....|....*....
gi 74582920 737 TVNSDTFKYYFGNAGHLHI 755
Cdd:cd17987 158 ALDVNLFIRYFGSCPVIYI 176
|
|
| DEXHc_DHX33 |
cd17978 |
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA ... |
577-755 |
3.56e-49 |
|
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA polymerase I transcription of the 47S precursor rRNA. DHX33 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438710 [Multi-domain] Cd Length: 178 Bit Score: 172.54 E-value: 3.56e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 577 LPAWESRRKIMDAIQHSQVVVISGETGSGKSTQVVQFILDhylsSGEKDLQTVVCTQPRRISAISLAERVAFERDTTVGK 656
Cdd:cd17978 1 LPIYSARKRLLEELRKHDTVIIIGETGSGKTTQIPQYLYE----AGFARGGMIGITQPRRVAAVSVAKRVAEEMGVELGQ 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 657 EVGYSVHGEKSISKETLLEFCTTGLLLRRIQQHGLgfLSTLSCVVVDEVHERSIENDILLTLLKLVISR-----IPNLKV 731
Cdd:cd17978 77 LVGYSVRFDDVTSEETRIKYMTDGMLLREAIGDPL--LSKYSVIILDEAHERTVHTDVLFGLVKSAQRRrkeqkLSPLKV 154
|
170 180
....*....|....*....|....
gi 74582920 732 ILMSATVNSDTFKYYFGNAGHLHI 755
Cdd:cd17978 155 IIMSATLDADLFSEYFNGAPVLYI 178
|
|
| DEXHc_DHX29 |
cd17975 |
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of ... |
577-747 |
7.59e-49 |
|
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of the 43S pre-initiation complex involved in translation initiation of mRNAs with structured 5'-UTRs. DHX29 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350733 [Multi-domain] Cd Length: 183 Bit Score: 172.02 E-value: 7.59e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 577 LPAWESRRKIMDAIQHSQVVVISGETGSGKSTQVVQFIL-DHYLSSGEKDLQTVVCTQPRRISAISLAERVAFERDTTVG 655
Cdd:cd17975 1 LPVFKHRESILETLKRHRVVVVAGETGSGKSTQVPQFLLeDLLLNGGTAQKCNIVCTQPRRISAMSLATRVCEELGCESG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 656 -----KEVGYSVHGEKSISKETLLEFCTTGLLLRRIQQHGLgfLSTLSCVVVDEVHERSIENDILLTLLKLVISRIPNLK 730
Cdd:cd17975 81 pggknSLCGYQIRMESRTGEATRLLYCTTGVLLRKLQEDGL--LSSISHIIVDEVHERSVQSDFLLIILKEILHKRSDLH 158
|
170
....*....|....*..
gi 74582920 731 VILMSATVNSDTFKYYF 747
Cdd:cd17975 159 LILMSATVDCEKFSSYF 175
|
|
| DEXHc_DHX34 |
cd17979 |
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in ... |
577-750 |
1.48e-48 |
|
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in the nonsense-mediated decay (NMD), a surveillance mechanism that degrades aberrant mRNAs. DHX34 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350737 [Multi-domain] Cd Length: 170 Bit Score: 170.32 E-value: 1.48e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 577 LPAWESRRKIMDAIQHSQVVVISGETGSGKSTQVVQFILDHYLSSgekdlqtVVCTQPRRISAISLAERVAFERDTTVGK 656
Cdd:cd17979 1 LPIAQYREKIIELLKTHQVVIVAGDTGCGKSTQVPQYLLAAGFRH-------IACTQPRRIACISLAKRVAFESLNQYGS 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 657 EVGYSVHGEKSISKETLLEFCTTGLLLRRIQQHGLgfLSTLSCVVVDEVHERSIENDILLTLLKLVISRIPNLKVILMSA 736
Cdd:cd17979 74 KVAYQIRFERTRTLATKLLFLTEGLLLRQIQRDAS--LPQYNVLILDEVHERHLHGDFLLGVLRCLLRLRPDLKLILMSA 151
|
170
....*....|....
gi 74582920 737 TVNSDTFKYYFGNA 750
Cdd:cd17979 152 TINIELFSGYFEGA 165
|
|
| DEXHc_DHX30 |
cd17976 |
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an ... |
577-755 |
3.04e-48 |
|
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an important role in the assembly of the mitochondrial large ribosomal subunit. DHX30 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350734 [Multi-domain] Cd Length: 178 Bit Score: 169.97 E-value: 3.04e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 577 LPAWESRRKIMDAIQHSQVVVISGETGSGKSTQVVQFILDHYLSSGEKDLQTVVCTQPRRISAISLAERVAFERDTTVGK 656
Cdd:cd17976 1 LPVDSHKESILSAIEQNPVVVISGDTGCGKTTRIPQFILEDYVLRGRGARCNVVITQPRRISAVSVAQRVAHELGPNLRR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 657 EVGYSVHGE-KSISKETLLEFCTTGLLLRRIQqhGLGFLSTLSCVVVDEVHERSIENDILLTLLKLVISRIPNLKVILMS 735
Cdd:cd17976 81 NVGYQVRLEsRPPPRGGALLFCTVGVLLKKLQ--SNPRLEGVSHVIVDEVHERDVNTDFLLILLKGVLQLNPELRVVLMS 158
|
170 180
....*....|....*....|
gi 74582920 736 ATVNSDTFKYYFGNAGHLHI 755
Cdd:cd17976 159 ATGDNQRLSRYFGGCPVVRV 178
|
|
| DEXHc_DHX38 |
cd17983 |
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as ... |
577-755 |
2.05e-45 |
|
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as PRP16) is involved in pre-mRNA splicing. DHX38 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350741 [Multi-domain] Cd Length: 173 Bit Score: 161.48 E-value: 2.05e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 577 LPAWESRRKIMDAIQHSQVVVISGETGSGKSTQVVQFIL-DHYLSSGekdlqTVVCTQPRRISAISLAERVAFERDTTVG 655
Cdd:cd17983 1 LPIFAVRQELLNVIRDNNVVIVVGETGSGKTTQLTQYLHeDGYTDYG-----MIGCTQPRRVAAMSVAKRVSEEMGVELG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 656 KEVGYSVHGEKSISKETLLEFCTTGLLLRRIQQHglGFLSTLSCVVVDEVHERSIENDILLTLLKLVISRIPNLKVILMS 735
Cdd:cd17983 76 EEVGYAIRFEDCTSENTVIKYMTDGILLRESLRD--PDLDKYSAIIMDEAHERSLNTDVLFGLLREVVARRRDLKLIVTS 153
|
170 180
....*....|....*....|
gi 74582920 736 ATVNSDTFKYYFGNAGHLHI 755
Cdd:cd17983 154 ATMDADKFADFFGNVPIFTI 173
|
|
| DEXHc_DHX35 |
cd17980 |
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and ... |
577-747 |
1.49e-44 |
|
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and seems to be associated with risk to thyroid cancers. It also has been shown to positively regulate poxviruses, such as Myxoma virus. DEAH-box helicase 35 (DHX35) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350738 [Multi-domain] Cd Length: 185 Bit Score: 159.56 E-value: 1.49e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 577 LPAWESRRKIMDAIQHSQVVVISGETGSGKSTQVVQFILDHYLSSGEKdlqTVVCTQPRRISAISLAERVAFERDTTVGK 656
Cdd:cd17980 1 LPVFKLRNHILYLVENYQTIVIVGETGCGKSTQIPQYLAEAGWTAGGR---VVGCTQPRRVAAVTVAGRVAEEMGAVLGH 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 657 EVGYSVHGEKSISK-ETLLEFCTTGLLLRRIQQHGLgfLSTLSCVVVDEVHERSIENDILLTLLKLVISRIPNLKVILMS 735
Cdd:cd17980 78 EVGYCIRFDDCTDPqATRIKFLTDGMLVREMMLDPL--LTKYSVIMLDEAHERTLYTDILIGLLKKIQKKRGDLRLIVAS 155
|
170
....*....|..
gi 74582920 736 ATVNSDTFKYYF 747
Cdd:cd17980 156 ATLDAEKFRDFF 167
|
|
| DEXHc_DHX8 |
cd17971 |
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as ... |
573-750 |
1.18e-42 |
|
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22) acts late in the splicing of pre-mRNA and mediates the release of the spliced mRNA from spliceosomes. DHX8 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350729 [Multi-domain] Cd Length: 179 Bit Score: 153.79 E-value: 1.18e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 573 EREKLPAWESRRKIMDAIQHSQVVVISGETGSGKSTQVVQFILDHYLSSGEKdlqtVVCTQPRRISAISLAERVAFERDT 652
Cdd:cd17971 2 QRESLPIYKLKEQLIQAVHDNQILVVIGETGSGKTTQITQYLAEAGYTSRGK----IGCTQPRRVAAMSVAKRVAEEFGC 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 653 TVGKEVGYSVHGEKSISKETLLEFCTTGLLLRRIQQHGLgfLSTLSCVVVDEVHERSIENDILLTLLKLVISRIPNLKVI 732
Cdd:cd17971 78 CLGQEVGYTIRFEDCTSPETVIKYMTDGMLLRECLIDPD--LSQYSVIMLDEAHERTIHTDVLFGLLKKTVQKRPDLKLI 155
|
170
....*....|....*...
gi 74582920 733 LMSATVNSDTFKYYFGNA 750
Cdd:cd17971 156 VTSATLDAVKFSQYFYEA 173
|
|
| DEXHc_DHX37 |
cd17982 |
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the ... |
577-743 |
4.27e-41 |
|
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the human nervous system and has been linked to schizophrenia. It also negatively regulates poxviruses such as Myxoma virus. DEAH-box helicase 37 (DHX37) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350740 [Multi-domain] Cd Length: 191 Bit Score: 149.81 E-value: 4.27e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 577 LPAWESRRKIMDAIQHSQVVVISGETGSGKSTQVVQFILDHYLSSGEKDLQTVV-CTQPRRISAISLAERVAFERdTTVG 655
Cdd:cd17982 1 LPILAEEQEIMEAINENPVVIICGETGSGKTTQVPQFLYEAGFGSPESDNPGMIgITQPRRVAAVSMAKRVAEEL-NVFG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 656 KEVGYSVHGEKSISKETLLEFCTTGLLLRRIQQHGLgfLSTLSCVVVDEVHERSIENDILLTLLKLVI----------SR 725
Cdd:cd17982 80 KEVSYQIRYDSTVSENTKIKFMTDGVLLKEIQTDFL--LRKYSVIIIDEAHERSVNTDILIGMLSRIVplraklylqdQT 157
|
170
....*....|....*...
gi 74582920 726 IPNLKVILMSATVNSDTF 743
Cdd:cd17982 158 VKPLKLVIMSATLRVEDF 175
|
|
| DEXHc_HrpA |
cd17989 |
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA ... |
577-750 |
4.30e-41 |
|
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpA belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350747 [Multi-domain] Cd Length: 173 Bit Score: 149.14 E-value: 4.30e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 577 LPAWESRRKIMDAIQHSQVVVISGETGSGKSTQVVQFILDhyLSSGEKDLqtVVCTQPRRISAISLAERVAFERDTTVGK 656
Cdd:cd17989 1 LPVSQKRDEIAKAIAENQVVIIAGETGSGKTTQLPKICLE--LGRGIRGL--IGHTQPRRLAARSVAERIAEELKTELGG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 657 EVGYSVHGEKSISKETLLEFCTTGLLLRRIQQHGlgFLSTLSCVVVDEVHERSIENDILLTLLKLVISRIPNLKVILMSA 736
Cdd:cd17989 77 AVGYKVRFTDQTSDETCVKLMTDGILLAETQTDR--YLRAYDTIIIDEAHERSLNIDFLLGYLKQLLPRRPDLKVIITSA 154
|
170
....*....|....
gi 74582920 737 TVNSDTFKYYFGNA 750
Cdd:cd17989 155 TIDAERFSRHFNNA 168
|
|
| DEXHc_DHX16 |
cd17974 |
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably ... |
577-750 |
4.33e-41 |
|
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably involved in pre-mRNA splicing. DHX16 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350732 [Multi-domain] Cd Length: 174 Bit Score: 149.19 E-value: 4.33e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 577 LPAWESRRKIMDAIQHSQVVVISGETGSGKSTQVVQFILDHYLSsgeKDLQTVVCTQPRRISAISLAERVAFERDTTVGK 656
Cdd:cd17974 1 LPVYPYRDDLLAAVKEHQVLIIVGETGSGKTTQIPQYLHEAGYT---KGGGKIGCTQPRRVAAMSVAARVAEEMGVKLGN 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 657 EVGYSVHGEKSISKETLLEFCTTGLLLRRIQQHglGFLSTLSCVVVDEVHERSIENDILLTLLKLVISRIPNLKVILMSA 736
Cdd:cd17974 78 EVGYSIRFEDCTSEKTVLKYMTDGMLLREFLTE--PDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPDLKLLISSA 155
|
170
....*....|....
gi 74582920 737 TVNSDTFKYYFGNA 750
Cdd:cd17974 156 TMDAEKFSAFFDDA 169
|
|
| DEXHc_TDRD9 |
cd17988 |
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also ... |
577-748 |
4.92e-40 |
|
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also known as HIG-1or NET54 or C14orf75) is a part of the nuclear PIWI-interacting RNA (piRNA) pathway essential for transposon silencing and male fertility TDRD9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350746 [Multi-domain] Cd Length: 180 Bit Score: 146.49 E-value: 4.92e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 577 LPAWESRRKIMDAIQHSQVVVISGETGSGKSTQVVQFILDHYLSSGEKdlQTVVCTQPRRISAISLAERVAFERDTTVGK 656
Cdd:cd17988 1 LPIYAKREEILSLIEANSVVIIKGATGCGKTTQLPQFILDHYYKRGKY--CNIVVTQPRRIAAISIARRVSQEREWTLGS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 657 EVGYSVHGEKSISKETLLEFCTTGLLLRRIQQhgLGFLSTLSCVVVDEVHERSIENDILLTLL-KLVISRIPNLKVILMS 735
Cdd:cd17988 79 LVGYQVGLERPASEETRLIYCTTGVLLQKLIN--NKTLTEYTHIILDEVHERDQELDFLLLVVrRLLRTNSRHVKIILMS 156
|
170
....*....|...
gi 74582920 736 ATVNSDTFKYYFG 748
Cdd:cd17988 157 ATISCKEFADYFT 169
|
|
| DEXHc_DHX32 |
cd17977 |
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the ... |
577-750 |
9.65e-37 |
|
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350735 [Multi-domain] Cd Length: 176 Bit Score: 136.88 E-value: 9.65e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 577 LPAWESRRKIMDAIQHSQVVVISGETGSGKSTQVVQFILDHYLSsGEKDLQTVVCTQPRRISAISLAERVAFERDTTVGK 656
Cdd:cd17977 1 LPVWEAKYEFMESLAHNQIVIVSGDAKTGKSSQIPQWCAEYCLS-AHYQHGVVVCTQVHKQTAVWLALRVADEMDVNIGH 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 657 EVGYSVHGEKSISKETLLEFCTTGLLLRRIQQHGLgfLSTLSCVVVDEVHERSIENDILLTLLKLVISRIPNLKVILMSA 736
Cdd:cd17977 80 EVGYVIPFENCCTNETILRYCTDDMLLREMMSDPL--LESYGVIILDDAHERTVSTDVLLGLLKDVLLSRPELKLVIITC 157
|
170
....*....|....
gi 74582920 737 TVNSDTFKYYFGNA 750
Cdd:cd17977 158 PHLSSKLLSYYGNV 171
|
|
| DEXHc_HrpB |
cd17990 |
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ... |
577-750 |
1.78e-36 |
|
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438711 [Multi-domain] Cd Length: 174 Bit Score: 135.92 E-value: 1.78e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 577 LPAWESRRKIMDAIQHSQVVVISGETGSGKSTQVVQFILDHYLSSGEKdlqtVVCTQPRRISAISLAERVAFERDTTVGK 656
Cdd:cd17990 1 LPIAAVLPALRAALDAGGQVVLEAPPGAGKTTRVPLALLAELWIAGGK----IIVLEPRRVAARAAARRLATLLGEAPGE 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 657 EVGYSVHGEKSISKETLLEFCTTGLLLRRIQQHGLgfLSTLSCVVVDEVHERSIENDILLTLL-KLVISRIPNLKVILMS 735
Cdd:cd17990 77 TVGYRVRGESRVGRRTRVEVVTEGVLLRRLQRDPE--LSGVGAVILDEFHERSLDADLALALLlEVQQLLRDDLRLLAMS 154
|
170
....*....|....*
gi 74582920 736 ATVNSDTFKYYFGNA 750
Cdd:cd17990 155 ATLDGDGLAALLPEA 169
|
|
| DEXHc_DHX40 |
cd17984 |
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the ... |
577-755 |
1.02e-34 |
|
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350742 [Multi-domain] Cd Length: 178 Bit Score: 131.13 E-value: 1.02e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 577 LPAWESRRKIMDAIQHSQVVVISGETGSGKSTQVVQFILDHYLSSGEKdlqtVVCTQPRRISAISLAERVAFERDTTVGK 656
Cdd:cd17984 1 LPIQKQRKKLVQAVRDNSFLIVTGNTGSGKTTQLPKYLYEAGFSQHGM----IGVTQPRRVAAISVAQRVAEEMKCTLGS 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 657 EVGYSVHGEKSISKETLLEFCTTGLLLRRIQQHGLgfLSTLSCVVVDEVHERSIENDILLTLL-KLVISRIPN----LKV 731
Cdd:cd17984 77 KVGYQVRFDDCSSKETAIKYMTDGCLLRHILADPN--LTKYSVIILDEAHERSLTTDILFGLLkKLFQEKSPNrkehLKV 154
|
170 180
....*....|....*....|....
gi 74582920 732 ILMSATVNSDTFKYYFGNAGHLHI 755
Cdd:cd17984 155 VVMSATLELAKLSAFFGNCPVFDI 178
|
|
| RWD_YLR419W-like |
cd23827 |
RWD domain of Saccharomyces cerevisiae putative ATP-dependent RNA helicase YLR419W and related ... |
403-505 |
1.91e-33 |
|
RWD domain of Saccharomyces cerevisiae putative ATP-dependent RNA helicase YLR419W and related proteins; YLR419W (EC 3.6.4.13) may act as an ATP-binding RNA helicase. The RWD domain may mediate protein-protein interactions.
Pssm-ID: 467662 Cd Length: 104 Bit Score: 124.67 E-value: 1.91e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 403 WDDDVSALQSILDNKVSKIE-NGCRVRIDYPTSEFGELFVDFRRPArSYPAHIPLMSLSSTKRMASYIKLSILKKMVVYA 481
Cdd:cd23827 1 WDEEIEALEAIYGEKFEVISdDSCEITLNSPTKTKPSLKLKFYKSS-SYPNSLPGIFISSSDKLPAYIKLAIIRQLLQYA 79
|
90 100
....*....|....*....|....*
gi 74582920 482 MD-LRGECMLSWLYNHLQENIEDFL 505
Cdd:cd23827 80 RDnLLGDPMIFSIVEWLEENIEEII 104
|
|
| DEXQc_DQX1 |
cd17986 |
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 ... |
577-755 |
1.15e-31 |
|
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 (DQX1) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350744 [Multi-domain] Cd Length: 177 Bit Score: 122.31 E-value: 1.15e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 577 LPAWESRRKIMDAIQ-HSQVVVISGETGSGKSTQVVQFILDHYLSSGEKDLQtVVCTQPRRISAISLAERVAFERDTTVG 655
Cdd:cd17986 1 LPIWAAKFTFLEQLEsPSGIVLVSGEPGSGKSTQVPQWCAEFALSRGFQKGQ-VTVTQPHPLAARSLALRVADEMDLNLG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 656 KEVGYSVHGEKSISKETLLEFCTTGLLLRRIQQHGLgfLSTLSCVVVDEVHERSIENDILLTLLKLVISRIPNLKVILMS 735
Cdd:cd17986 80 HEVGYSIPQEDCTGPNTILRFCWDRLLLQEMTSTPL--LGAWGVVVLDEAQERSVASDSLLGLLKDVRLQRPELRVVVVT 157
|
170 180
....*....|....*....|
gi 74582920 736 ATVNSDTFKYYFGNAGHLHI 755
Cdd:cd17986 158 SPALEPKLRAFWGNPPVVHV 177
|
|
| PHA02653 |
PHA02653 |
RNA helicase NPH-II; Provisional |
581-930 |
2.59e-22 |
|
RNA helicase NPH-II; Provisional
Pssm-ID: 177443 [Multi-domain] Cd Length: 675 Bit Score: 103.52 E-value: 2.59e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 581 ESRRKIMDAIQHSQVVVISGETGSGKSTQVVQFIL-DHYLSSGEKDLQTVVCTQPRRISAISLAeRVAFERDT--TVGKE 657
Cdd:PHA02653 167 DVQLKIFEAWISRKPVVLTGGTGVGKTSQVPKLLLwFNYLFGGFDNLDKIDPNFIERPIVLSLP-RVALVRLHsiTLLKS 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 658 VGYS-VHGE------KSISKETL--------LEFCTTGLLLRRIQQHglgflstlSCVVVDEVHERSIENDILLTLLKLV 722
Cdd:PHA02653 246 LGFDeIDGSpislkyGSIPDELIntnpkpygLVFSTHKLTLNKLFDY--------GTVIIDEVHEHDQIGDIIIAVARKH 317
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 723 ISRIPNLkvILMSATVNSD--TFKYYFGNAGHLHIHGRT-FPIKDYYIEdfapklNEDDdeedvPRRKKKEYEIDYHLIS 799
Cdd:PHA02653 318 IDKIRSL--FLMTATLEDDrdRIKEFFPNPAFVHIPGGTlFPISEVYVK------NKYN-----PKNKRAYIEEEKKNIV 384
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 800 RLVSSIDAELGSSsgsILVFlpgVSNIARCI--REIKSKDGSKFEVLPLHAS-LNTSEQRRcfKTYTKRK--IICATNIA 874
Cdd:PHA02653 385 TALKKYTPPKGSS---GIVF---VASVSQCEeyKKYLEKRLPIYDFYIIHGKvPNIDEILE--KVYSSKNpsIIISTPYL 456
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 74582920 875 ETSITIDDVVAVIDSGRVKQidydveRDLVTFKETWASRAACQQRRGRAGRVKKGI 930
Cdd:PHA02653 457 ESSVTIRNATHVYDTGRVYV------PEPFGGKEMFISKSMRTQRKGRVGRVSPGT 506
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
589-750 |
2.56e-20 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 90.63 E-value: 2.56e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 589 AIQHSQVVVISGETGSGKSTQVVQFILDHYLSSGEKdlqTVVCTQPRRISAISLAERVAFERDTTVGKEVGYsVHGEKSI 668
Cdd:smart00487 20 LLSGLRDVILAAPTGSGKTLAALLPALEALKRGKGG---RVLVLVPTRELAEQWAEELKKLGPSLGLKVVGL-YGGDSKR 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 669 SKETLLE-------FCTTGLLLRRIQQHGLgFLSTLSCVVVDEVHERSIEN--DILLTLLKLVisrIPNLKVILMSATVN 739
Cdd:smart00487 96 EQLRKLEsgktdilVTTPGRLLDLLENDKL-SLSNVDLVILDEAHRLLDGGfgDQLEKLLKLL---PKNVQLLLLSATPP 171
|
170
....*....|...
gi 74582920 740 SDT--FKYYFGNA 750
Cdd:smart00487 172 EEIenLLELFLND 184
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
596-737 |
3.00e-16 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 77.06 E-value: 3.00e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 596 VVISGETGSGKSTQVVQFILDHYLSSGEKdlqtVVCTQPRRISAISLAERVAFERDTtvGKEVGYSVHGEKSISKETLLE 675
Cdd:cd00046 4 VLITAPTGSGKTLAALLAALLLLLKKGKK----VLVLVPTKALALQTAERLRELFGP--GIRVAVLVGGSSAEEREKNKL 77
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 74582920 676 ------FCTTGLLLRRIQQHGLGFLSTLSCVVVDEVHERSIENDILLTLLKLVISRI-PNLKVILMSAT 737
Cdd:cd00046 78 gdadiiIATPDMLLNLLLREDRLFLKDLKLIIVDEAHALLIDSRGALILDLAVRKAGlKNAQVILLSAT 146
|
|
| RWD |
smart00591 |
domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily ... |
406-504 |
6.30e-16 |
|
domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain;
Pssm-ID: 214735 Cd Length: 107 Bit Score: 74.70 E-value: 6.30e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 406 DVSALQSILDNKVSKIEN---GCRVRIDYPTSEFG------ELFVDFRRPArSYPAHIPLMSLSSTKRMASYIKLSILKK 476
Cdd:smart00591 1 ELEALESIYPEDFEVIDEdarIPEITIKLSPSSDEgedqyvSLTLQVKLPE-NYPDEAPPISLLNSEGLSDEQLAELLKK 79
|
90 100
....*....|....*....|....*...
gi 74582920 477 MVVYAMDLRGECMLSWLYNHLQENIEDF 504
Cdd:smart00591 80 LEEIAEENLGEVMIFELVEKLQEFLSEF 107
|
|
| HA2 |
pfam04408 |
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ... |
1002-1078 |
7.44e-15 |
|
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 461295 [Multi-domain] Cd Length: 104 Bit Score: 71.50 E-value: 7.44e-15
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 74582920 1002 ALKKLIQVGALTVSEDLTGLGEYLVSLPIDLKLGKLLVFGSIFGYLEPALTITAILSTKSPFLGDDEAREIRSKQSQ 1078
Cdd:pfam04408 1 ALELLYYLGALDEDGELTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRDPFVQPNFLDPRSAAKAA 77
|
|
| HA2 |
smart00847 |
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ... |
1008-1085 |
9.78e-15 |
|
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 214852 [Multi-domain] Cd Length: 82 Bit Score: 70.37 E-value: 9.78e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 1008 QVGALTVSEDLTGLGEYLVSLPIDLKLGKLLVFGSIFGYLEPALTITAILSTKSPFLGD--DEAREIRSKQSQGWGDVLA 1085
Cdd:smart00847 1 ELGALDDDGRLTPLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLSVGDPRPKEkrEDADAARRRFADPESDHLT 80
|
|
| OB_NTP_bind |
pfam07717 |
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ... |
1158-1258 |
1.88e-13 |
|
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.
Pssm-ID: 400182 [Multi-domain] Cd Length: 82 Bit Score: 66.89 E-value: 1.88e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 1158 LSTLIAAALSPNVVKCVYPDKKFVASFsgslemeqearltkfydqNNQRLFIHPSSTMFvnSPNASRCTFVAYEQKVETT 1237
Cdd:pfam07717 1 LRAALAAGLYPNVARRDPKGKGYTTLS------------------DNQRVFIHPSSVLF--NEKTFPPEWVVYQELVETT 60
|
90 100
....*....|....*....|.
gi 74582920 1238 KPFLRNCTPINTYGMILLGAN 1258
Cdd:pfam07717 61 KVYIRTVTAISPEWLLLFAPH 81
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
811-927 |
3.76e-11 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 61.07 E-value: 3.76e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 811 SSSGSILVFLPGVSNIArcIREIKSKDGskFEVLPLHASLNTSEQRRCFKTYT--KRKIICATNIAETSITIDDVVAVid 888
Cdd:pfam00271 13 ERGGKVLIFSQTKKTLE--AELLLEKEG--IKVARLHGDLSQEEREEILEDFRkgKIDVLVATDVAERGLDLPDVDLV-- 86
|
90 100 110
....*....|....*....|....*....|....*....
gi 74582920 889 sgrvkqIDYDVERDLVTFKetwasraacqQRRGRAGRVK 927
Cdd:pfam00271 87 ------INYDLPWNPASYI----------QRIGRAGRAG 109
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
840-927 |
2.13e-10 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 58.38 E-value: 2.13e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 840 KFEVLPLHASLNTSEQRRCFKTYT--KRKIICATNIAETSITIDDVVAVIDSGrvkqidydverdlvtfkeTWASRAACQ 917
Cdd:smart00490 11 GIKVARLHGGLSQEEREEILDKFNngKIKVLVATDVAERGLDLPGVDLVIIYD------------------LPWSPASYI 72
|
90
....*....|
gi 74582920 918 QRRGRAGRVK 927
Cdd:smart00490 73 QRIGRAGRAG 82
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
584-741 |
1.93e-09 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 58.02 E-value: 1.93e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 584 RKIMDAIQHSQVVVISGETGSGKSTQVVQFILDHyLSSGEKDLQTVVCTqPRRisaiSLAE---RVAFERDTTVGKEVGY 660
Cdd:pfam00270 5 AEAIPAILEGRDVLVQAPTGSGKTLAFLLPALEA-LDKLDNGPQALVLA-PTR----ELAEqiyEELKKLGKGLGLKVAS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 661 SVHGEKSISKETLLEFC-----TTGLLLRRIQQhgLGFLSTLSCVVVDEVHErsIENDILLTLLKLVISRIP-NLKVILM 734
Cdd:pfam00270 79 LLGGDSRKEQLEKLKGPdilvgTPGRLLDLLQE--RKLLKNLKLLVLDEAHR--LLDMGFGPDLEEILRRLPkKRQILLL 154
|
....*..
gi 74582920 735 SATVNSD 741
Cdd:pfam00270 155 SATLPRN 161
|
|
| RWD |
pfam05773 |
RWD domain; This domain was identified in WD40 repeat proteins and Ring finger domain proteins. ... |
402-501 |
2.71e-09 |
|
RWD domain; This domain was identified in WD40 repeat proteins and Ring finger domain proteins. The function of this domain is unknown. GCN2 is the alpha-subunit of the only translation initiation factor (eIF2 alpha) kinase that appears in all eukaryotes. Its function requires an interaction with GCN1 via the domain at its N-terminus, which is termed the RWD domain after three major RWD-containing proteins: RING finger-containing proteins, WD-repeat-containing proteins, and yeast DEAD (DEXD)-like helicases. The structure forms an alpha + beta sandwich fold consisting of two layers: a four-stranded antiparallel beta-sheet, and three side-by-side alpha-helices.
Pssm-ID: 399058 Cd Length: 111 Bit Score: 56.18 E-value: 2.71e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 402 EWDDDVSALQSILDNKVSKIENGC------RVRID-----YPTSEFGELFVDFRRPArSYPAHIPLMSLSSTKRMASYIK 470
Cdd:pfam05773 2 EQEEELEALESIYPDEFEVISDSPyesleiEIKLSldsdeSDSSHLPPLVLKFTLPE-DYPDEPPKISLSSPWNLSDEQV 80
|
90 100 110
....*....|....*....|....*....|.
gi 74582920 471 LSILKKMVVYAMDLRGECMLSWLYNHLQENI 501
Cdd:pfam05773 81 LSLLEELEELAEENLGEVMIFELIEWLQENL 111
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
596-756 |
1.08e-08 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 56.12 E-value: 1.08e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 596 VVISGETGSGKSTQVVQFILDHYLSSGekdlQTVVCTQPRRisaiSLAERVAF---ERDTTVGKEVGYsVHGEKSISKET 672
Cdd:cd17921 20 VLVSAPTSSGKTLIAELAILRALATSG----GKAVYIAPTR----ALVNQKEAdlrERFGPLGKNVGL-LTGDPSVNKLL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 673 LLEF----CTT---GLLLRRIQQhglGFLSTLSCVVVDEVH--ERSIENDILLTLLKLVISRIPNLKVILMSATV-NSDT 742
Cdd:cd17921 91 LAEAdilvATPeklDLLLRNGGE---RLIQDVRLVVVDEAHliGDGERGVVLELLLSRLLRINKNARFVGLSATLpNAED 167
|
170
....*....|....
gi 74582920 743 FKYYFGNAGHLHIH 756
Cdd:cd17921 168 LAEWLGVEDLIRFD 181
|
|
| cas3_core |
TIGR01587 |
CRISPR-associated helicase Cas3; This model represents the highly conserved core region of an ... |
596-881 |
1.04e-05 |
|
CRISPR-associated helicase Cas3; This model represents the highly conserved core region of an alignment of Cas3, a protein found in association with CRISPR repeat elements in a broad range of bacteria and archaea. Cas3 appears to be a helicase, with regions found by pfam00270 (DEAD/DEAH box helicase) and pfam00271 (Helicase conserved C-terminal domain). Some but not all members have an N-terminal HD domain region (pfam01966) that is not included within this model.
Pssm-ID: 273707 [Multi-domain] Cd Length: 359 Bit Score: 49.37 E-value: 1.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 596 VVISGETGSGKSTQVVQFILdHYLSSGEKDlqTVVCTQPRRISAISLAERV-AFERDTTVGKEVGYSVHGEKS-ISKETL 673
Cdd:TIGR01587 2 LVIEAPTGYGKTEAALLWAL-HSIKSQKAD--RVIIALPTRATINAMYRRAkELFGSELVGLHHSSSFSRIKEmGDSEEF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 674 LEFCT-----------TGLLLRRIQQ------HGLGFLST------LSCVVVDEVH--ERSIeNDILLTLLKLVisRIPN 728
Cdd:TIGR01587 79 EHLFPlyihsndklflDPITVCTIDQvlksvfGEFGHYEFtlasiaNSLLIFDEVHfyDEYT-LALILAVLEVL--KDND 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 729 LKVILMSATVnSDTFKYYFGNAGhlhihgrtfpikdYYIEDFAPKLNEDDDEEDVPRRKK-KEYEIDYHLISRLVSSIDA 807
Cdd:TIGR01587 156 VPILLMSATL-PKFLKEYAEKIG-------------YVEFNEPLDLKEERRFENHRFILIeSDKVGEISSLERLLEFIKK 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 808 ElgsssGSILVFLPGVSNIARCIREIKSKdGSKFEVLPLHASLNTSEQRRC-------FKTYTKRKIICATNIAETSITI 880
Cdd:TIGR01587 222 G-----GSIAIIVNTVDRAQEFYQQLKEK-APEEEIILYHSRFTEKDRAKKeaellreMKKSNEKFVIVATQVIEASLDI 295
|
.
gi 74582920 881 D 881
Cdd:TIGR01587 296 S 296
|
|
| RWD_DRWD_ELF-like |
cd11605 |
RWD, DRWD, and ELF domain family; The family includes the RWD, double-RWD (DRWD), and ELF ... |
409-497 |
1.37e-05 |
|
RWD, DRWD, and ELF domain family; The family includes the RWD, double-RWD (DRWD), and ELF domains. They belong to the ubiquitin-conjugating (UBC) superfamily that represents a structural domain with an alpha-beta(4)-alpha(3) core fold. The RWD domain (named after three major RWD-containing proteins: RING finger, WD-repeat-containing proteins and DEXD-like helicases) mediates protein-protein interactions in a variety of pathways in eukaryotes. The DRWD domain is responsible for substrate binding. It is involved in interactions with other kinetochore proteins. The ELF (N-terminal E2-like fold) domain is found in all Fanconi anemia group L protein (FANCL) homologs. It is required to promote efficient DNA damage-induced FANCD2 (Fanconi anemia group D2 protein) monoubiquitination in vertebrate cells.
Pssm-ID: 467641 Cd Length: 94 Bit Score: 44.87 E-value: 1.37e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 409 ALQSILDNKVSKIENGCRVRI-----DYPTSEFGELFVDFRRPARSYPAHIPLMSLSSTKRMASYIKLSILKKMVVYAMD 483
Cdd:cd11605 1 ALESIYGDELEVLSDDSPLRFsirlsPEEEEDDPPLELEFTLPPGYPPEEPPLITLRSPKLSSAERLSLLKLELEEAAEE 80
|
90
....*....|....
gi 74582920 484 LRGECMLSWLYNHL 497
Cdd:cd11605 81 NLGEPMLFDLVEAL 94
|
|
| Cas3_I |
cd09639 |
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short ... |
596-908 |
6.73e-05 |
|
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I
Pssm-ID: 187770 [Multi-domain] Cd Length: 353 Bit Score: 46.65 E-value: 6.73e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 596 VVISGETGSGKSTQVVQFILdHYLSSGEKDlqTVVCTQPRRISAISLAERV-AFERDTTVGKEVGYSVHGEKSISKETLL 674
Cdd:cd09639 2 LVIEAPTGYGKTEAALLWAL-HSLKSQKAD--RVIIALPTRATINAMYRRAkEAFGETGLYHSSILSSRIKEMGDSEEFE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 675 EFCT-----------TGLLLRRIQQ------HGLGFLST------LSCVVVDEVH--ERSIeNDILLTLLKLVisRIPNL 729
Cdd:cd09639 79 HLFPlyihsndtlflDPITVCTIDQvlksvfGEFGHYEFtlasiaNSLLIFDEVHfyDEYT-LALILAVLEVL--KDNDV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 730 KVILMSATVnSDTFKYYFGNAGhlhihgrtfpikdYYIEDFAPKLNEDDDEEDVPRRKKKEYEIDyhLISRLVSSIDAEl 809
Cdd:cd09639 156 PILLMSATL-PKFLKEYAEKIG-------------YVEENEPLDLKPNERAPFIKIESDKVGEIS--SLERLLEFIKKG- 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 810 gsssGSILVFLPGVSNIARCIREIKSKdGSKFEVLPLHASLNTSEQRR---CFKTYTKRK---IICATNIAETSITID-D 882
Cdd:cd09639 219 ----GSVAIIVNTVDRAQEFYQQLKEK-GPEEEIMLIHSRFTEKDRAKkeaELLLEFKKSekfVIVATQVIEASLDISvD 293
|
330 340 350
....*....|....*....|....*....|....*
gi 74582920 883 VV----AVIDS-----GRVKQIDYDVERDLVTFKE 908
Cdd:cd09639 294 VMitelAPIDSliqrlGRLHRYGEKNGEEVYIITD 328
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
596-738 |
1.94e-04 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 45.66 E-value: 1.94e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 596 VVISGETGSGKsTQVVQFILDHYLSSGEKDLQTVvctqPRRisaiSLAERVA--FERD-TTVGKEVG-----YSVHGEKS 667
Cdd:COG1204 41 LVVSAPTASGK-TLIAELAILKALLNGGKALYIV----PLR----ALASEKYreFKRDfEELGIKVGvstgdYDSDDEWL 111
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 74582920 668 ISKETLLefCT---TGLLLRriqqHGLGFLSTLSCVVVDEVH-----ERSIENDILLTLLKlviSRIPNLKVILMSATV 738
Cdd:COG1204 112 GRYDILV--ATpekLDSLLR----NGPSWLRDVDLVVVDEAHliddeSRGPTLEVLLARLR---RLNPEAQIVALSATI 181
|
|
| DEXHc_archSki2 |
cd18028 |
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play ... |
596-753 |
4.69e-04 |
|
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play an important role in RNA degradation, processing and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350786 [Multi-domain] Cd Length: 177 Bit Score: 42.71 E-value: 4.69e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 596 VVISGETGSGKsTQVVQFILDHYLSSGEKDLQTVvctqPRRisAISLAERVAFERDTTVGKEVGYSVhGEKSISKETLLE 675
Cdd:cd18028 20 LLISIPTASGK-TLIAEMAMVNTLLEGGKALYLV----PLR--ALASEKYEEFKKLEEIGLKVGIST-GDYDEDDEWLGD 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 676 F---CTTGLLLRRIQQHGLGFLSTLSCVVVDEVH-----ERSIENDILLTLLKLVisrIPNLKVILMSATVnsdtfkyyf 747
Cdd:cd18028 92 YdiiVATYEKFDSLLRHSPSWLRDVGVVVVDEIHlisdeERGPTLESIVARLRRL---NPNTQIIGLSATI--------- 159
|
....*.
gi 74582920 748 GNAGHL 753
Cdd:cd18028 160 GNPDEL 165
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
510-929 |
5.84e-04 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 44.25 E-value: 5.84e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 510 SLLNISAATIGVSLSSQNKSAPTAKKNNSFKPKLFRRSRELSEKLCNNWSERVKSPSYQLKVREREKLPAWESR------ 583
Cdd:COG1061 1 VLLRGIAERGADKLRSSLLLLDLERLELSLLRNLVEARRLAIKEGTREDGRRLPEEDTERELAEAEALEAGDEAsgtsfe 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 584 -----RKIMDAI-----QHSQVVVISGETGSGKSTqVVQFILDHYLSSGekdlQTVVCTqPRRISAISLAERvaFERDTT 653
Cdd:COG1061 81 lrpyqQEALEALlaaleRGGGRGLVVAPTGTGKTV-LALALAAELLRGK----RVLVLV-PRRELLEQWAEE--LRRFLG 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 654 VGKEVGysvhGEKSISKETLleFCTTGLLLRRIQQHGLGFLSTLscVVVDEVHERSIENdilltlLKLVISRIPNLKVIL 733
Cdd:COG1061 153 DPLAGG----GKKDSDAPIT--VATYQSLARRAHLDELGDRFGL--VIIDEAHHAGAPS------YRRILEAFPAAYRLG 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 734 MSAT-VNSDT----FKYYFG-----------NAGHLHIHgRTFPIKDyyieDFAPKLNEDDDEEDvprRKKKEYEIDYHL 797
Cdd:COG1061 219 LTATpFRSDGreilLFLFDGivyeyslkeaiEDGYLAPP-EYYGIRV----DLTDERAEYDALSE---RLREALAADAER 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 798 ISRLVSSIDAELGsSSGSILVFLPGVS---NIARCIREIkskdgsKFEVLPLHASLNTSEQRRCFKTY--TKRKIICATN 872
Cdd:COG1061 291 KDKILRELLREHP-DDRKTLVFCSSVDhaeALAELLNEA------GIRAAVVTGDTPKKEREEILEAFrdGELRILVTVD 363
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*...
gi 74582920 873 IAETSITIDDV-VAVIDSGRvkqidydverdlvtfketwASRAACQQRRGRAGRVKKG 929
Cdd:COG1061 364 VLNEGVDVPRLdVAILLRPT-------------------GSPREFIQRLGRGLRPAPG 402
|
|
| UBA |
pfam00627 |
UBA/TS-N domain; This small domain is composed of three alpha helices. This family includes ... |
277-312 |
6.37e-04 |
|
UBA/TS-N domain; This small domain is composed of three alpha helices. This family includes the previously defined UBA and TS-N domains. The UBA-domain (ubiquitin associated domain) is a novel sequence motif found in several proteins having connections to ubiquitin and the ubiquitination pathway. The structure of the UBA domain consists of a compact three helix bundle. This domain is found at the N terminus of EF-TS hence the name TS-N. The structure of EF-TS is known and this domain is implicated in its interaction with EF-TU. The domain has been found in non EF-TS proteins such as alpha-NAC and MJ0280.
Pssm-ID: 395502 [Multi-domain] Cd Length: 37 Bit Score: 38.58 E-value: 6.37e-04
10 20 30
....*....|....*....|....*....|....*..
gi 74582920 277 PDTSIVNDLISLGFRDIHAKEACQYCV-SLEDALEWL 312
Cdd:pfam00627 1 EDEEAIQRLVEMGFDREQVREALRATGnNVERAAEYL 37
|
|
| AAA_22 |
pfam13401 |
AAA domain; |
591-734 |
7.73e-04 |
|
AAA domain;
Pssm-ID: 379165 [Multi-domain] Cd Length: 129 Bit Score: 40.79 E-value: 7.73e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 591 QHSQVVVISGETGSGKSTqVVQFILDHyLSSGEKDLQTVVCTQPRriSAISLAERVAferdttvgKEVGYSVHGEKSISK 670
Cdd:pfam13401 3 FGAGILVLTGESGTGKTT-LLRRLLEQ-LPEVRDSVVFVDLPSGT--SPKDLLRALL--------RALGLPLSGRLSKEE 70
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 74582920 671 etllefcttglLLRRIQQHGLGfLSTLSCVVVDEVHerSIENDILLTLLKLVISRIPNLKVILM 734
Cdd:pfam13401 71 -----------LLAALQQLLLA-LAVAVVLIIDEAQ--HLSLEALEELRDLLNLSSKLLQLILV 120
|
|
| PRK02362 |
PRK02362 |
ATP-dependent DNA helicase; |
682-819 |
1.76e-03 |
|
ATP-dependent DNA helicase;
Pssm-ID: 235032 [Multi-domain] Cd Length: 737 Bit Score: 42.64 E-value: 1.76e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 682 LLRriqqHGLGFLSTLSCVVVDEVH-----ER--SIEndilLTLLKLViSRIPNLKVILMSATVnsdtfkyyfGNAGHLH 754
Cdd:PRK02362 127 LLR----NGAPWLDDITCVVVDEVHlidsaNRgpTLE----VTLAKLR-RLNPDLQVVALSATI---------GNADELA 188
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 74582920 755 -------IHGRTFPI---KDYYIEDfapKLNEDDDEEDVPRRKKKEyeidyhlISRLVSSIDAELGSSsgsiLVF 819
Cdd:PRK02362 189 dwldaelVDSEWRPIdlrEGVFYGG---AIHFDDSQREVEVPSKDD-------TLNLVLDTLEEGGQC----LVF 249
|
|
| CDC6 |
COG1474 |
Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]; |
596-747 |
7.58e-03 |
|
Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];
Pssm-ID: 441083 [Multi-domain] Cd Length: 389 Bit Score: 40.22 E-value: 7.58e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 596 VVISGETGSGKSTqVVQFILDH---YLSSGEKDLQTVV--CTQPR---RIsAISLAERVAFerdttvgkevGYSVHgEKS 667
Cdd:COG1474 54 VLIYGPTGTGKTA-VAKYVLEEleeEAEERGVDVRVVYvnCRQAStryRV-LSRILEELGS----------GEDIP-STG 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582920 668 ISKETLLEfcttgLLLRRIQQHGLGFLstlscVVVDEVH--ERSIENDILLTLLKLViSRIPNLKV--ILMSatvNSDTF 743
Cdd:COG1474 121 LSTDELFD-----RLYEALDERDGVLV-----VVLDEIDylVDDEGDDLLYQLLRAN-EELEGARVgvIGIS---NDLEF 186
|
....
gi 74582920 744 KYYF 747
Cdd:COG1474 187 LENL 190
|
|
| |
