NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|12229732|sp|O89046|]
View 

RecName: Full=Coronin-1B; AltName: Full=Coronin-2

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-480 5.16e-110

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member PTZ00421:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 493  Bit Score: 334.94  E-value: 5.16e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229732   10 SKFRHVFGQPVKNDQCYEDIRVSRVTWD-STFCAVNPKFLAVIVEASGGGAfmVLPLNKTGRIDKAYPTVCGHTGPVLDI 88
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTA--VLKHTDYGKLASNPPILLGQEGPIIDV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229732   89 DWCPHNDEVIASGSEDCTVMVWQIPENGLTSPLTEPVVVLEGHTKRVGIITWHPTARNVLLSAGCDNVVLIWNV--GTAE 166
Cdd:PTZ00421  82 AFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVerGKAV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229732  167 ELYrldSLHPDLIYNVSWNHNGSLFCTACKDKSVRIIDPRRGTLVAEREkAHEGARPMRAIFLADGK-VFTAGFSRMSER 245
Cdd:PTZ00421 162 EVI---KCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVE-AHASAKSQRCLWAKRKDlIITLGCSKSQQR 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229732  246 QLALWDPENFEEPMALQELDSSNGALLPFYDPDTSVVYVCGKGDSSIRYFEITDEPpyIHFLNTFTSKEPQRGMGSMPKR 325
Cdd:PTZ00421 238 QIMLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNER--LTFCSSYSSVEPHKGLCMMPKW 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229732  326 GLEVSKCEIARFYKLHERKCEPIVMTVPRK-SDL-FQDDLYPDTAGPDAALEAEDWVSGQDADPILISL--------REA 395
Cdd:PTZ00421 316 SLDTRKCEIARFYALTYHSLYTIQMLLPRKqADSeLQVDVYPPTFADHPAITADEYFSGGNAEPLVYDMsavfdgtsPEL 395

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229732  396 YVPSKQRDLKVSRRNVLSDSKPAGYSRSGVSTATAITDIPSGNLAGSGEAGKLEEVMHGLRALRVLVKEQGERISRLEEH 475
Cdd:PTZ00421 396 MGASALSPSGKPRHSGVSVPASTSAMTHSFDDNTSKHADPCAMGVKRMDEGILDERLGRLQALSEKLRTQHEEIKRCREA 475


                 ....*
gi 12229732  476 LGRME 480
Cdd:PTZ00421 476 LQKKE 480
 
Name Accession Description Interval E-value
PTZ00421 PTZ00421
coronin; Provisional
 10-480 5.16e-110

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 334.94  E-value: 5.16e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229732   10 SKFRHVFGQPVKNDQCYEDIRVSRVTWD-STFCAVNPKFLAVIVEASGGGAfmVLPLNKTGRIDKAYPTVCGHTGPVLDI 88
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTA--VLKHTDYGKLASNPPILLGQEGPIIDV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229732   89 DWCPHNDEVIASGSEDCTVMVWQIPENGLTSPLTEPVVVLEGHTKRVGIITWHPTARNVLLSAGCDNVVLIWNV--GTAE 166
Cdd:PTZ00421  82 AFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVerGKAV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229732  167 ELYrldSLHPDLIYNVSWNHNGSLFCTACKDKSVRIIDPRRGTLVAEREkAHEGARPMRAIFLADGK-VFTAGFSRMSER 245
Cdd:PTZ00421 162 EVI---KCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVE-AHASAKSQRCLWAKRKDlIITLGCSKSQQR 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229732  246 QLALWDPENFEEPMALQELDSSNGALLPFYDPDTSVVYVCGKGDSSIRYFEITDEPpyIHFLNTFTSKEPQRGMGSMPKR 325
Cdd:PTZ00421 238 QIMLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNER--LTFCSSYSSVEPHKGLCMMPKW 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229732  326 GLEVSKCEIARFYKLHERKCEPIVMTVPRK-SDL-FQDDLYPDTAGPDAALEAEDWVSGQDADPILISL--------REA 395
Cdd:PTZ00421 316 SLDTRKCEIARFYALTYHSLYTIQMLLPRKqADSeLQVDVYPPTFADHPAITADEYFSGGNAEPLVYDMsavfdgtsPEL 395

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229732  396 YVPSKQRDLKVSRRNVLSDSKPAGYSRSGVSTATAITDIPSGNLAGSGEAGKLEEVMHGLRALRVLVKEQGERISRLEEH 475
Cdd:PTZ00421 396 MGASALSPSGKPRHSGVSVPASTSAMTHSFDDNTSKHADPCAMGVKRMDEGILDERLGRLQALSEKLRTQHEEIKRCREA 475


                 ....*
gi 12229732  476 LGRME 480
Cdd:PTZ00421 476 LQKKE 480
DUF1899 pfam08953
Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic ...
 5-70 1.32e-37

Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic proteins. Function is unknown.


Pssm-ID: 462645 [Multi-domain]  Cd Length: 66  Bit Score: 131.85  E-value: 1.32e-37
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 12229732     5 KVVRQSKFRHVFGQPVKNDQCYEDIRVSRVTWDSTFCAVNPKFLAVIVEASGGGAFMVLPLNKTGR 70
Cdd:pfam08953   1 RFVRASKFRHVYGKPAKKELCYDNIKVTKNAWDSNFIAANPKFLAVNWESSGGGAFAVLPLNQTGR 66
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 77-297 1.82e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 108.58  E-value: 1.82e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229732  77 TVCGHTGPVLDIDWCPHnDEVIASGSEDCTVMVWQIPENgltspltEPVVVLEGHTKRVGIITWHPTARnVLLSAGCDNV 156
Cdd:cd00200  46 TLKGHTGPVRDVAASAD-GTYLASGSSDKTIRLWDLETG-------ECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKT 116

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229732 157 VLIWNVGTAEELYRLDSlHPDLIYNVSWNHNGSLFCTACKDKSVRIIDPRRGTLVAEREkAHEGarPMRAI-FLADGKVF 235
Cdd:cd00200 117 IKVWDVETGKCLTTLRG-HTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLT-GHTG--EVNSVaFSPDGEKL 192

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 12229732 236 TAGFsrmSERQLALWDPENFEEpmaLQELDSSNGALL-PFYDPDTSVVyVCGKGDSSIRYFEI 297
Cdd:cd00200 193 LSSS---SDGTIKLWDLSTGKC---LGTLRGHENGVNsVAFSPDGYLL-ASGSEDGTIRVWDL 248
WD40 COG2319
WD40 repeat [General function prediction only];
77-262 1.23e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 99.60  E-value: 1.23e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229732  77 TVCGHTGPVLDIDWCPhNDEVIASGSEDCTVMVWQIPENgltspltEPVVVLEGHTKRVGIITWHPTARnVLLSAGCDNV 156
Cdd:COG2319 199 TLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATG-------KLLRTLTGHSGSVRSVAFSPDGR-LLASGSADGT 269

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229732 157 VLIWNVGTAEELYRLDSlHPDLIYNVSWNHNGSLFCTACKDKSVRIIDPRRGTLVAEReKAHEGARpmRAI-FLADGK-V 234
Cdd:COG2319 270 VRLWDLATGELLRTLTG-HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL-TGHTGAV--RSVaFSPDGKtL 345

                       170       180
                ....*....|....*....|....*...
gi 12229732 235 FTAGfsrmSERQLALWDPENFEEPMALQ 262
Cdd:COG2319 346 ASGS----DDGTVRLWDLATGELLRTLT 369
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 80-110 1.06e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 1.06e-06
                           10        20        30
                   ....*....|....*....|....*....|.
gi 12229732     80 GHTGPVLDIDWCPhNDEVIASGSEDCTVMVW 110
Cdd:smart00320  10 GHTGPVTSVAFSP-DGKYLASGSDDGTIKLW 39
 
Name Accession Description Interval E-value
PTZ00421 PTZ00421
coronin; Provisional
 10-480 5.16e-110

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 334.94  E-value: 5.16e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229732   10 SKFRHVFGQPVKNDQCYEDIRVSRVTWD-STFCAVNPKFLAVIVEASGGGAfmVLPLNKTGRIDKAYPTVCGHTGPVLDI 88
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTA--VLKHTDYGKLASNPPILLGQEGPIIDV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229732   89 DWCPHNDEVIASGSEDCTVMVWQIPENGLTSPLTEPVVVLEGHTKRVGIITWHPTARNVLLSAGCDNVVLIWNV--GTAE 166
Cdd:PTZ00421  82 AFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVerGKAV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229732  167 ELYrldSLHPDLIYNVSWNHNGSLFCTACKDKSVRIIDPRRGTLVAEREkAHEGARPMRAIFLADGK-VFTAGFSRMSER 245
Cdd:PTZ00421 162 EVI---KCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVE-AHASAKSQRCLWAKRKDlIITLGCSKSQQR 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229732  246 QLALWDPENFEEPMALQELDSSNGALLPFYDPDTSVVYVCGKGDSSIRYFEITDEPpyIHFLNTFTSKEPQRGMGSMPKR 325
Cdd:PTZ00421 238 QIMLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNER--LTFCSSYSSVEPHKGLCMMPKW 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229732  326 GLEVSKCEIARFYKLHERKCEPIVMTVPRK-SDL-FQDDLYPDTAGPDAALEAEDWVSGQDADPILISL--------REA 395
Cdd:PTZ00421 316 SLDTRKCEIARFYALTYHSLYTIQMLLPRKqADSeLQVDVYPPTFADHPAITADEYFSGGNAEPLVYDMsavfdgtsPEL 395

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229732  396 YVPSKQRDLKVSRRNVLSDSKPAGYSRSGVSTATAITDIPSGNLAGSGEAGKLEEVMHGLRALRVLVKEQGERISRLEEH 475
Cdd:PTZ00421 396 MGASALSPSGKPRHSGVSVPASTSAMTHSFDDNTSKHADPCAMGVKRMDEGILDERLGRLQALSEKLRTQHEEIKRCREA 475


                 ....*
gi 12229732  476 LGRME 480
Cdd:PTZ00421 476 LQKKE 480
PTZ00420 PTZ00420
coronin; Provisional
 19-409 1.09e-67

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 227.14  E-value: 1.09e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229732   19 PVKNDQCYEDIRV-SRVTwDSTFCAVNPKFLAVIVEASGGGAFMVLPLNKTGRidkaYPTVC---GHTGPVLDIDWCPHN 94
Cdd:PTZ00420  12 PDPSNNLFDDLRIcSRVI-DSCGIACSSGFVAVPWEVEGGGLIGAIRLENQMR----KPPVIklkGHTSSILDLQFNPCF 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229732   95 DEVIASGSEDCTVMVWQIPENGLT-SPLTEPVVVLEGHTKRVGIITWHPTARNVLLSAGCDNVVLIWNVGTAEELYRLds 173
Cdd:PTZ00420  87 SEILASGSEDLTIRVWEIPHNDESvKEIKDPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIENEKRAFQI-- 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229732  174 LHPDLIYNVSWNHNGSLFCTACKDKSVRIIDPRRGTlVAEREKAHEGARPMRAIFL-----ADGKVFTAGFSRMSERQLA 248
Cdd:PTZ00420 165 NMPKKLSSLKWNIKGNLLSGTCVGKHMHIIDPRKQE-IASSFHIHDGGKNTKNIWIdglggDDNYILSTGFSKNNMREMK 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229732  249 LWDPENFEEPMALQELDSSNGALLPFYDPDTSVVYVCGKGDSSIRYFEITDEPpyIHFLNTFTSKEPQRGMGSMPKRGLE 328
Cdd:PTZ00420 244 LWDLKNTTSALVTMSIDNASAPLIPHYDESTGLIYLIGKGDGNCRYYQHSLGS--IRKVNEYKSCSPFRSFGFLPKQICD 321

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229732  329 VSKCEIARFYK-LHERKCEPIVMTVPRK-SDLFQDDLYPDTAGPDAALEAEDWVSGQDADPILISLREAyvpsKQRDLKV 406
Cdd:PTZ00420 322 VYKCEIGRVYKnENNSSIRPISFYVPRKnPTKFQEDLYPPILMHDPERSSRNWIDGKDNKMKRINIKDL----TEDDLRI 397


                 ...
gi 12229732  407 SRR 409
Cdd:PTZ00420 398 TKK 400
DUF1899 pfam08953
Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic ...
 5-70 1.32e-37

Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic proteins. Function is unknown.


Pssm-ID: 462645 [Multi-domain]  Cd Length: 66  Bit Score: 131.85  E-value: 1.32e-37
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 12229732     5 KVVRQSKFRHVFGQPVKNDQCYEDIRVSRVTWDSTFCAVNPKFLAVIVEASGGGAFMVLPLNKTGR 70
Cdd:pfam08953   1 RFVRASKFRHVYGKPAKKELCYDNIKVTKNAWDSNFIAANPKFLAVNWESSGGGAFAVLPLNQTGR 66
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 77-297 1.82e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 108.58  E-value: 1.82e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229732  77 TVCGHTGPVLDIDWCPHnDEVIASGSEDCTVMVWQIPENgltspltEPVVVLEGHTKRVGIITWHPTARnVLLSAGCDNV 156
Cdd:cd00200  46 TLKGHTGPVRDVAASAD-GTYLASGSSDKTIRLWDLETG-------ECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKT 116

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229732 157 VLIWNVGTAEELYRLDSlHPDLIYNVSWNHNGSLFCTACKDKSVRIIDPRRGTLVAEREkAHEGarPMRAI-FLADGKVF 235
Cdd:cd00200 117 IKVWDVETGKCLTTLRG-HTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLT-GHTG--EVNSVaFSPDGEKL 192

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 12229732 236 TAGFsrmSERQLALWDPENFEEpmaLQELDSSNGALL-PFYDPDTSVVyVCGKGDSSIRYFEI 297
Cdd:cd00200 193 LSSS---SDGTIKLWDLSTGKC---LGTLRGHENGVNsVAFSPDGYLL-ASGSEDGTIRVWDL 248
WD40 COG2319
WD40 repeat [General function prediction only];
77-262 1.23e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 99.60  E-value: 1.23e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229732  77 TVCGHTGPVLDIDWCPhNDEVIASGSEDCTVMVWQIPENgltspltEPVVVLEGHTKRVGIITWHPTARnVLLSAGCDNV 156
Cdd:COG2319 199 TLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATG-------KLLRTLTGHSGSVRSVAFSPDGR-LLASGSADGT 269

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229732 157 VLIWNVGTAEELYRLDSlHPDLIYNVSWNHNGSLFCTACKDKSVRIIDPRRGTLVAEReKAHEGARpmRAI-FLADGK-V 234
Cdd:COG2319 270 VRLWDLATGELLRTLTG-HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL-TGHTGAV--RSVaFSPDGKtL 345

                       170       180
                ....*....|....*....|....*...
gi 12229732 235 FTAGfsrmSERQLALWDPENFEEPMALQ 262
Cdd:COG2319 346 ASGS----DDGTVRLWDLATGELLRTLT 369
WD40 COG2319
WD40 repeat [General function prediction only];
80-299 1.02e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 96.90  E-value: 1.02e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229732  80 GHTGPVLDIDWCPhNDEVIASGSEDCTVMVWQIpENGltspltEPVVVLEGHTKRVGIITWHPTARnVLLSAGCDNVVLI 159
Cdd:COG2319 118 GHTGAVRSVAFSP-DGKTLASGSADGTVRLWDL-ATG------KLLRTLTGHSGAVTSVAFSPDGK-LLASGSDDGTVRL 188

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229732 160 WNVGTAEELYRLDSlHPDLIYNVSWNHNGSLFCTACKDKSVRIIDPRRGTLVAEREkaHEGARPMRAIFLADGKVFTAGf 239
Cdd:COG2319 189 WDLATGKLLRTLTG-HTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLT--GHSGSVRSVAFSPDGRLLASG- 264

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 12229732 240 srMSERQLALWDPENFEEpmaLQELDSSNGALLPF-YDPDTSVVyVCGKGDSSIRYFEITD 299
Cdd:COG2319 265 --SADGTVRLWDLATGEL---LRTLTGHSGGVNSVaFSPDGKLL-ASGSDDGTVRLWDLAT 319
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 80-213 3.45e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.55  E-value: 3.45e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229732  80 GHTGPVLDIDWCPHNDeVIASGSEDCTVMVWQIPENgltspltEPVVVLEGHTKRVGIITWHPTARNvLLSAGCDNVVLI 159
Cdd:cd00200 133 GHTDWVNSVAFSPDGT-FVASSSQDGTIKLWDLRTG-------KCVATLTGHTGEVNSVAFSPDGEK-LLSSSSDGTIKL 203

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 12229732 160 WNVGTAEELYRLDSlHPDLIYNVSWNHNGSLFCTACKDKSVRIIDPRRGTLVAE 213
Cdd:cd00200 204 WDLSTGKCLGTLRG-HENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQT 256
WD40_4 pfam16300
Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at ...
 345-387 1.75e-18

Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at the N-terminus of coronin proteins.


Pssm-ID: 465087 [Multi-domain]  Cd Length: 44  Bit Score: 78.71  E-value: 1.75e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 12229732   345 CEPIVMTVPRKS-DLFQDDLYPDTAGPDAALEAEDWVSGQDADP 387
Cdd:pfam16300   1 IEPISFTVPRKSkEDFQDDLYPDTAGTEPALTAEEWLSGKNAEP 44
WD40 COG2319
WD40 repeat [General function prediction only];
35-206 2.10e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 86.89  E-value: 2.10e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229732  35 TWDSTFCAVNP--KFLAViveASGGGAFMVLPLNkTGRIDKAYPtvcGHTGPVLDIDWCPhNDEVIASGSEDCTVMVWQI 112
Cdd:COG2319 246 SGSVRSVAFSPdgRLLAS---GSADGTVRLWDLA-TGELLRTLT---GHSGGVNSVAFSP-DGKLLASGSDDGTVRLWDL 317

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229732 113 PENgltspltEPVVVLEGHTKRVGIITWHPTARnVLLSAGCDNVVLIWNVGTAEELYRLDSlHPDLIYNVSWNHNGSLFC 192
Cdd:COG2319 318 ATG-------KLLRTLTGHTGAVRSVAFSPDGK-TLASGSDDGTVRLWDLATGELLRTLTG-HTGAVTSVAFSPDGRTLA 388

                       170
                ....*....|....
gi 12229732 193 TACKDKSVRIIDPR 206
Cdd:COG2319 389 SGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 80-202 5.75e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 81.23  E-value: 5.75e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229732  80 GHTGPVLDIDWCPhNDEVIASGSEDCTVMVWQIPEngltsplTEPVVVLEGHTKRVGIITWHPTaRNVLLSAGCDNVVLI 159
Cdd:cd00200 175 GHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLST-------GKCLGTLRGHENGVNSVAFSPD-GYLLASGSEDGTIRV 245

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 12229732 160 WNVGTAEELYRLdSLHPDLIYNVSWNHNGSLFCTACKDKSVRI 202
Cdd:cd00200 246 WDLRTGECVQTL-SGHTNSVTSLAWSPDGKRLASGSADGTIRI 287
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 127-293 7.61e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 68.90  E-value: 7.61e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229732 127 VLEGHTKRVGIITWHPTaRNVLLSAGCDNVVLIWNVGTAEELYRLdSLHPDLIYNVSWNHNGSLFCTACKDKSVRIIDPR 206
Cdd:cd00200   4 TLKGHTGGVTCVAFSPD-GKLLATGSGDGTIKVWDLETGELLRTL-KGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229732 207 RGTLVaeRE-KAHEGarPMRAI-FLADGKVFTAGfsrMSERQLALWDPENFEEPMALQelDSSNGALLPFYDPDTSVVyV 284
Cdd:cd00200  82 TGECV--RTlTGHTS--YVSSVaFSPDGRILSSS---SRDKTIKVWDVETGKCLTTLR--GHTDWVNSVAFSPDGTFV-A 151


                ....*....
gi 12229732 285 CGKGDSSIR 293
Cdd:cd00200 152 SSSQDGTIK 160
WD40 COG2319
WD40 repeat [General function prediction only];
80-164 2.73e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.77  E-value: 2.73e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229732  80 GHTGPVLDIDWCPhNDEVIASGSEDCTVMVWQIPENGLtspltepVVVLEGHTKRVGIITWHPTARnVLLSAGCDNVVLI 159
Cdd:COG2319 328 GHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLATGEL-------LRTLTGHTGAVTSVAFSPDGR-TLASGSADGTVRL 398


                ....*
gi 12229732 160 WNVGT 164
Cdd:COG2319 399 WDLAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 80-110 1.06e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 1.06e-06
                           10        20        30
                   ....*....|....*....|....*....|.
gi 12229732     80 GHTGPVLDIDWCPhNDEVIASGSEDCTVMVW 110
Cdd:smart00320  10 GHTGPVTSVAFSP-DGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
77-110 7.19e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 7.19e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 12229732    77 TVCGHTGPVLDIDWCPhNDEVIASGSEDCTVMVW 110
Cdd:pfam00400   6 TLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVW 38
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 175-299 2.78e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 45.79  E-value: 2.78e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229732 175 HPDLIYNVSWNHNGSLFCTACKDKSVRIIDPRRGTLVAeREKAHEGarPMRAI-FLADGK-VFTAGfsrmSERQLALWDP 252
Cdd:cd00200   8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLR-TLKGHTG--PVRDVaASADGTyLASGS----SDKTIRLWDL 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 12229732 253 ENFEEpmaLQELDSSNGALL-PFYDPDTSVVyVCGKGDSSIRYFEITD 299
Cdd:cd00200  81 ETGEC---VRTLTGHTSYVSsVAFSPDGRIL-SSSSRDKTIKVWDVET 124
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 123-161 9.20e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 9.20e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 12229732    123 EPVVVLEGHTKRVGIITWHPTaRNVLLSAGCDNVVLIWN 161
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPD-GKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 175-204 3.37e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 3.37e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 12229732    175 HPDLIYNVSWNHNGSLFCTACKDKSVRIID 204
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
123-161 9.15e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 9.15e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 12229732   123 EPVVVLEGHTKRVGIITWHPTaRNVLLSAGCDNVVLIWN 161
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPD-GKLLASGSDDGTVKVWD 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 67-111 1.29e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.78  E-value: 1.29e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 12229732  67 KTGRIDKaypTVCGHTGPVLDIDWCPHNDeVIASGSEDCTVMVWQ 111
Cdd:cd00200 249 RTGECVQ---TLSGHTNSVTSLAWSPDGK-RLASGSADGTIRIWD 289
WD40 pfam00400
WD domain, G-beta repeat;
175-204 3.13e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 3.13e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 12229732   175 HPDLIYNVSWNHNGSLFCTACKDKSVRIID 204
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH