BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily S member 3 (KCNS3); KCNS3, also called delayed-rectifier K(+) channel alpha subunit 3 or voltage-gated potassium channel subunit Kv9.3, is an alpha subunit of voltage-gated potassium channel linked to tissue oxygenation responses. It can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNS3 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24418459  15 ELVNLNVGGFKQSVDQSTLLRFPHTRLGKLLTCHSEEAILELCDDYSVADKEYYFDRNPSLFRYVLNFYYTGKLHVMEEL 94
Cdd:cd18428   1 ELINLNVGGFKQSVDQSTLLRFPHTRLGKLLNCHSEEAILELCDDYSVADKEYYFDRNPSLFRYVLNFYYTGKLHVMEEL 80

                        90       100
                ....*....|....*....|....*...
gi 24418459  95 CVFSFCQEIEYWGINELFIDSCCSSRYQ 122
Cdd:cd18428  81 CVFSFCQEIEYWGINELFIDSCCSNRYQ 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily S member 3 (KCNS3); KCNS3, also called delayed-rectifier K(+) channel alpha subunit 3 or voltage-gated potassium channel subunit Kv9.3, is an alpha subunit of voltage-gated potassium channel linked to tissue oxygenation responses. It can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNS3 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24418459  15 ELVNLNVGGFKQSVDQSTLLRFPHTRLGKLLTCHSEEAILELCDDYSVADKEYYFDRNPSLFRYVLNFYYTGKLHVMEEL 94
Cdd:cd18428   1 ELINLNVGGFKQSVDQSTLLRFPHTRLGKLLNCHSEEAILELCDDYSVADKEYYFDRNPSLFRYVLNFYYTGKLHVMEEL 80

                        90       100
                ....*....|....*....|....*...
gi 24418459  95 CVFSFCQEIEYWGINELFIDSCCSSRYQ 122
Cdd:cd18428  81 CVFSFCQEIEYWGINELFIDSCCSNRYQ 108

BTB/POZ domain; In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24418459    17 VNLNVGGFKQSVDQSTLLRFPHTRLGKLLTCHseeailelCDDYSVADKEYYFDRNPSLFRYVLNFYYT-GKLHVMEELC 95
Cdd:pfam02214   1 VKLNVGGTRFETLKSTLTRFPDTRLGRLLELE--------CDDYDDDTNEYFFDRSPKHFETILNFYRTgGKLHRPEEVC 72

                          90       100
                  ....*....|....*....|.
gi 24418459    96 VFSFCQEIEYWGINELFIDSC 116
Cdd:pfam02214  73 LDEFLEEAEFYGLDELALELC 93

voltage-gated potassium channel protein;

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24418459  335 ISIFSVLIYSV-----EKDELASSLTSIPICWWWATISMTTVGYGDTHPVTLAGKIIASTCIICGILVVALPITIIF 406
Cdd:PRK10537 142 ISITSLLFYSTfgalyLGDGFSPPIESLSTAFYFSIVTMSTVGYGDIVPVSESARLFTISVIILGITVFATSISAIF 218

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily S member 3 (KCNS3); KCNS3, also called delayed-rectifier K(+) channel alpha subunit 3 or voltage-gated potassium channel subunit Kv9.3, is an alpha subunit of voltage-gated potassium channel linked to tissue oxygenation responses. It can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNS3 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24418459  15 ELVNLNVGGFKQSVDQSTLLRFPHTRLGKLLTCHSEEAILELCDDYSVADKEYYFDRNPSLFRYVLNFYYTGKLHVMEEL 94
Cdd:cd18428   1 ELINLNVGGFKQSVDQSTLLRFPHTRLGKLLNCHSEEAILELCDDYSVADKEYYFDRNPSLFRYVLNFYYTGKLHVMEEL 80

                        90       100
                ....*....|....*....|....*...
gi 24418459  95 CVFSFCQEIEYWGINELFIDSCCSSRYQ 122
Cdd:cd18428  81 CVFSFCQEIEYWGINELFIDSCCSNRYQ 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily S member 2 (KCNS2); KCNS2, also called delayed-rectifier K(+) channel alpha subunit 2 or voltage-gated potassium channel subunit Kv9.2, is a modulatory alpha subunit of voltage-gated potassium channel that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1) and KCNB2 (also known as Kv2.2), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNS2 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24418459  17 VNLNVGGFKQSVDQSTLLRFPHTRLGKLLTCHSEEAILELCDDYSVADKEYYFDRNPSLFRYVLNFYYTGKLHVMEELCV 96
Cdd:cd18427   2 ISINVGGFKKRLRSHTLLRFPETRLGRLLSCRSKESILELCDDYDDTKNEFYFDRNPELFPYVLHFYNTGKLHVMGELCV 81

                        90       100
                ....*....|....*....|....*.
gi 24418459  97 FSFCQEIEYWGINELFIDSCCSSRYQ 122
Cdd:cd18427  82 FSFSQEIEYWGINEFFIDSCCSYSYH 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNB/Kv2 subfamily of Shab-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv3, also known as subfamily C, contains two alpha subunit members, Kv2.1 (KCNB1) and Kv2.2 (KCNB2), which are orthologs of the Shab gene in Drosophila. They are delayed-rectifier potassium currents in various neurons, although their physiological roles often remain elusive. Kv2/KCNB subfamily alpha subunits form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24418459  17 VNLNVGGFKQSVDQSTLLRFPHTRLGKLLTCHSEEAILELCDDYSVADKEYYFDRNPSLFRYVLNFYYTGKLHVMEELCV 96
Cdd:cd18378   4 VLLNVGGVRHEVLWRTLDRLPRTRLGRLRECNTHESLLELCDDYDLEDNEYFFDRHPGAFTSILNFYRTGKLHMPEEMCV 83

                        90       100
                ....*....|....*....|....*.
gi 24418459  97 FSFCQEIEYWGINELFIDSCCSSRYQ 122
Cdd:cd18378  84 LSFSQELEYWGIDEIYLESCCQHRYH 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster potassium voltage-gated channel protein Shab and similar proteins; Shab is a slow delayed rectifier voltage-gated potassium channel in Drosophila. It mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. Shab is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24418459  17 VNLNVGGFKQSVDQSTLLRFPHTRLGKLLTCHSEEAILELCDDYSVADKEYYFDRNPSLFRYVLNFYYTGKLHVMEELCV 96
Cdd:cd18413   4 VVINVGGVKHEVLWRTLDRMPHTRLGKLRDSNTHEAIVELCDDYSLADNEYFFDRHPRSFASILNFYRTGKLHLVEEMCV 83

                        90       100
                ....*....|....*....|....*.
gi 24418459  97 FSFCQEIEYWGINELFIDSCCSSRYQ 122
Cdd:cd18413  84 LAFSDDLEYWGVDELYLESCCQHKYH 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily B member 2 (KCNB2); KCNB2, also called voltage-gated potassium channel subunit Kv2.2, mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNB2 contributes to the delayed-rectifier voltage-gated potassium current in cortical pyramidal neurons and smooth muscle cells. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNB2 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24418459  17 VNLNVGGFKQSVDQSTLLRFPHTRLGKLLTCHSEEAILELCDDYSVADKEYYFDRNPSLFRYVLNFYYTGKLHVMEELCV 96
Cdd:cd18412  19 VKINVGGLNHEVLWRTLDRLPRTRLGKLRDCNTHESLLEVCDDYNLNENEYFFDRHPGAFTSILNFYRTGKLHMMEEMCA 98

                        90       100
                ....*....|....*....|....*....
gi 24418459  97 FSFCQEIEYWGINELFIDSCCSSRYQERK 125
Cdd:cd18412  99 LSFGQELDYWGIDEIYLESCCQARYHQKK 127

BTB/POZ domain; In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24418459    17 VNLNVGGFKQSVDQSTLLRFPHTRLGKLLTCHseeailelCDDYSVADKEYYFDRNPSLFRYVLNFYYT-GKLHVMEELC 95
Cdd:pfam02214   1 VKLNVGGTRFETLKSTLTRFPDTRLGRLLELE--------CDDYDDDTNEYFFDRSPKHFETILNFYRTgGKLHRPEEVC 72

                          90       100
                  ....*....|....*....|.
gi 24418459    96 VFSFCQEIEYWGINELFIDSC 116
Cdd:pfam02214  73 LDEFLEEAEFYGLDELALELC 93

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNG/Kv6 subfamily of potassium voltage-gated channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv6, also known as subfamily G, includes KCNG1 (Kv6.1), KCNG2 (Kv6.2 or KCNF2), KCNG3 (Kv6.3) and KCNG4 (Kv6.4), which are regulatory alpha subunits and do not form functional channels on their own. KCNG1 can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. KCNG2, also called cardiac potassium channel subunit, can form functional heterodimeric channels with KCNB1, and further modulates channel activity by shifting the threshold and the half-maximal activation to more negative values. KCNG3, also called voltage-gated potassium channel subunit Kv10.1, is an electrically silent modulatory subunit that can form functional heterotetrameric channels with KCNB1, and further promotes a reduction in the rate of activation and inactivation of the delayed rectifier voltage-gated potassium channel KCNB1. KCNG4 is a silent voltage-gated potassium (KvS) channel subunit that can form functional heterotetrameric channels with KCNB1, and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24418459  19 LNVGGFKQSVDQSTLLRFPHTRLGKLLTCHSEEAILELCDDYSVADKEYYFDRNPSLFRYVLNFYYTGKLHVMEELCVFS 98
Cdd:cd18382   3 INVGGARYSLPWSTLDRFPLTRLSRLKACRSEDDILRVCDDYDVERNEFFFDRSPEAFGVILLFLRAGKLRLLREMCALS 82

                        90       100
                ....*....|....*....|....*.
gi 24418459  99 FCQEIEYWGINELFIDSCCSSRYQER 124
Cdd:cd18382  83 FQEELAYWGIEEAHLERCCKRRLLRR 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily V member 2 (KCNV2); KCNV2, also called voltage-gated potassium channel subunit Kv8.2, is a modulatory voltage-gated potassium channel alpha subunit that modulates channel activity by shifting the threshold and the half-maximal activation to more negative values. KCNV2 is essential for visual function and cone survival. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNV2 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24418459  17 VNLNVGGFKQSVDQSTLLRFPHTRLGKLLTCHSEEAILELCDDYSVADKEYYFDRNPSLFRYVLNFYYTGKLHVMEELCV 96
Cdd:cd18425   1 LNINVGGTSYQISYRVAASYPKTRIGRLATYTDRSRKLDLCDDYNVQNDEYFFDRDPAVFHHIYNFYRTGVLWVKDELCP 80

                        90       100
                ....*....|....*....|....*...
gi 24418459  97 FSFCQEIEYWGINELFIDSCCSSRYQER 124
Cdd:cd18425  81 RNFLEEINYWGVRIKNTPRCCRISFEER 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNF/Kv5 subfamily of potassium voltage-gated channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv5, also known as subfamily F, only contains KCNF1 (also known as Kv5.1 or kH1), which functions as a regulatory alpha-subunit of voltage-gated potassium channel that when coassembled with Kv2.1 can modulate gating in a physiologically relevant manner. It forms hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24418459  17 VNLNVGGFKQSVDQSTLLRFPHTRLGKLLTCHSE--EAILELCDDYSVADKEYYFDRNPSLFRYVLNFYYTGKLHVMEEL 94
Cdd:cd18381   3 IVVNVGGVRQVLYGDVLNRYPETRLAELLNCLSGgyDAIFSLCDDYDPGKREFYFDRDPDAFKCIIEVYYYGEIHMKKGI 82

                        90       100       110
                ....*....|....*....|....*....|...
gi 24418459  95 CVFSFCQEIEYWGINELFIDSCCSSRYQERKEE 127
Cdd:cd18381  83 CPICFKNEMDFWRVDLDFLDECCKCHLSEKREE 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily G member 3 (KCNG3); KCNG3, also called voltage-gated potassium channel subunit Kv6.3 or voltage-gated potassium channel subunit Kv10.1, is an electrically silent modulatory subunit that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further promotes a reduction in the rate of activation and inactivation of the delayed rectifier voltage-gated potassium channel KCNB1. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNG3 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24418459  17 VNLNVGGFKQSVDQSTLLRFPHTRLGKLLTCHSEEAILELCDDYSVADKEYYFDRNPSLFRYVLNFYYTGKLHVMEELCV 96
Cdd:cd18422   1 VTLNVGGTRYSFSREVIKDFPLRRVSRLHGCLSEQDVLEVCDDYDRERNEYFFDRHSEAFGFIMLYVKYGKLRFVPQMCE 80

                        90       100       110
                ....*....|....*....|....*....|.
gi 24418459  97 FSFCQEIEYWGINELFIDSCCSSRYQERKEE 127
Cdd:cd18422  81 LSFYNEMIYWGLERSHLEYCCQRRLDDRMSD 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC1 and KCNC3; KCNC1 (also called NGK2, voltage-gated potassium channel subunit Kv3.1, or voltage-gated potassium channel subunit Kv4) and KCNC3 (also called KSHIIID or voltage-gated potassium channel subunit Kv3.3) play important roles in the rapid repolarization of fast-firing brain neurons. Assuming opened or closed conformations in response to the voltage difference across the membrane, the proteins form tetrameric potassium-selective channels through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNC1 and KCNC3 are alpha subunit that form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24418459  13 DEELVNLNVGGFKQSVDQSTLLRFPHTRLGKLLtchSEEAILELcdDYSVADKEYYFDRNPSLFRYVLNFYYTGKLHVME 92
Cdd:cd18414   1 ESDRIVINVGGTRHETYRSTLRTLPGTRLAWLA---EPDAHSNF--DYDPRADEFFFDRHPGVFAHILNYYRTGKLHCPA 75

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 24418459  93 ELCVFSFCQEIEYWGINELFIDSCCSSRYQERKEESHEKD 132
Cdd:cd18414  76 DVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALD 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 3 (KCND3); KCND3, also called voltage-gated potassium channel subunit Kv4.3, is a pore-forming subunit of voltage-gated rapidly inactivating A-type potassium channels. Mutations in KCND3 cause spinocerebellar ataxia. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND3 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24418459  12 QDEELVNLNVGGFKQSVDQSTLLRFPHTRLGKlltchSEEAILelcddYSVADKEYYFDRNPSLFRYVLNFYYTGKLHVM 91
Cdd:cd18419  32 RQDELIVLNVSGRRFQTWRTTLERYPDTLLGS-----TEKEFF-----FNEDTKEYFFDRDPEVFRCVLNFYRTGKLHYP 101

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 24418459  92 EELCVFSFCQEIEYWGINELFIDSCCSSRYQERKEES 128
Cdd:cd18419 102 RYECISAYDEELAFYGILPEIIGDCCYEEYKDRKREN 138

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 2 (KCND2); KCND2, also called voltage-gated potassium channel subunit Kv4.2, is a major pore-forming subunit in somatodendritic subthreshold A-type potassium current I(SA) channels. It mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND2 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24418459  16 LVNLNVGGFKQSVDQSTLLRFPHTRLGKlltchSEEAILelcddYSVADKEYYFDRNPSLFRYVLNFYYTGKLHVMEELC 95
Cdd:cd18418   1 LIVLNVSGTRFQTWRNTLERYPDTLLGS-----SERDFF-----YHEETQEYFFDRDPDIFRHILNFYRTGKLHYPRHEC 70

                        90       100       110
                ....*....|....*....|....*....|...
gi 24418459  96 VFSFCQEIEYWGINELFIDSCCSSRYQERKEES 128
Cdd:cd18418  71 ISAYDEELAFFGIIPEIIGDCCYEEYKDRRREN 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster potassium voltage-gated channel protein Shal and similar proteins; Drosophila melanogaster Shal, also called Shaker cognate l or Shal2, is a transient potassium current (I(A)) channel, which is required for maintaining excitability during repetitive firing and normal locomotion in Drosophila. It may play a role in the nervous system and in the regulation of beating frequency in pacemaker cells. Shal mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. Shal is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24418459  13 DEELVNLNVGGFKQSVDQSTLLRFPHTRLGKlltchSEEAILelcddYSVADKEYYFDRNPSLFRYVLNFYYTGKLHVME 92
Cdd:cd18420  34 DDEKLIINVSGRRFETWRNTLEKYPDTLLGS-----NEREFF-----YDEETKEYFFDRDPDIFRHILNYYRTGKLHYPK 103

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 24418459  93 ELCVFSFCQEIEYWGINELFIDSCCSSRYQERKEES 128
Cdd:cd18420 104 HECLTAYDEELAFFGIMPDIIGDCCYEDYRDRKREN 139

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins; The potassium channel tetramerization domain (KCTD) family proteins contain the BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels and others. Some KCTD proteins are involved in protein ubiquitination as part of the CRL (Cullin RING Ligase) E3 ligases. Some others show Cullin-independent functions including binding and regulation of GABA (gamma-aminobutyric acid) receptors (KCTD8, KCTD12 and KCTD16) and inhibition of AP-2 function (KCTD15). KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24418459  17 VNLNVGGFKQSVDQSTLLRFPHTRLGKLLTCHSEEAILElcddysvaDKEYYFDRNPSLFRYVLNFYYTGKLHV------ 90
Cdd:cd18316   1 VKLNVGGTLFTTSRSTLLKDPDSLLAALFSGRWPLPRDE--------DGSIFIDRDPELFRHILNFLRTGKLPLpsdfve 72

                        90
                ....*....|....*.
gi 24418459  91 MEELcvfsfCQEIEYW 106
Cdd:cd18316  73 LEEL-----LAEAEFY 83

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24418459   330 FLSVGISIFSVLIYSVEKDELASSLTSIpicwWWATISMTTVGYGDTHPVTLAGKIIASTCIICGILVVALPITIIFNKF 409
Cdd:pfam07885   1 IVLLLVLIFGTVYYLLEEGWEWSFLDAL----YFSFVTLTTVGYGDIVPLTDAGRLFTIFYILIGIPLFAIFLAVLGRFL 76

                  ..
gi 24418459   410 SK 411
Cdd:pfam07885  77 TE 78

voltage-gated potassium channel protein;

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24418459  335 ISIFSVLIYSV-----EKDELASSLTSIPICWWWATISMTTVGYGDTHPVTLAGKIIASTCIICGILVVALPITIIF 406
Cdd:PRK10537 142 ISITSLLFYSTfgalyLGDGFSPPIESLSTAFYFSIVTMSTVGYGDIVPVSESARLFTISVIILGITVFATSISAIF 218

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 4 (KCTD4); KCTD4 is a BTB/POZ domain-containing protein with an unknown biological function. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels and others. Some KCTD proteins are involved in protein ubiquitination as part of the CRL (Cullin RING Ligase) E3 ligases. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24418459  16 LVNLNVGGFKQSVDQSTLLRFPHTRLGKLLTchseEAILELCDdysvADKEYYFDRNPSLFRYVLNFYYTGKLHVME 92
Cdd:cd18364   1 LVTLNVGGYLYITQRQTLTKYPDSFLEGMVN----GKIQCTVD----ADGNYFIDRDGLLFRHVLNFLRNGELLLPE 69

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD1 and KCTD15; This subfamily of KCTD proteins includes KCTD1 and KCTD15. KCTD1 is a nuclear BTB/POZ domain-containing protein that acts as a transcriptional repressor and mediates protein-protein interactions through a BTB domain. It represses the transcriptional activity of AP-2 family members, including TFAP2A, TFAP2B and TFAP2C. It also functions as a novel inhibitor of the Wnt signaling pathway. Mutations in KCTD1 cause scalp-ear-nipple (SEN) syndrome. KCTD15 is a BTB/POZ domain-containing protein that plays a role in the regulation of neural crest (NC) formation and other steps in embryonic development. It inhibits AP2 transcriptional activity by interaction with its activation domain. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD1 BTB domains form pentamers.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24418459  17 VNLNVGGFKQSVDQSTLLRFPHTRLGKLLTcHSEEAILElcddysvADKEYYF-DRNPSLFRYVLNFYYTGKLHVMEELC 95
Cdd:cd18361   1 VHIDVGGHIYTSSLETLTKYPESRLGKLFN-GSIPIVLD-------SLKQHYFiDRDGKMFRHILNFLRTSKLLLPDDFT 72

                        90
                ....*....|....*..
gi 24418459  96 VFS-FCQEIEYWGINEL 111
Cdd:cd18361  73 EFDlLYEEARYYELQPM 89

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 16 (KCTD16); KCTD16 is a BTB/POZ domain-containing protein that is an auxiliary subunit of GABAB receptors associated with mood disorders. It interacts with amyloid beta precursor protein (APP), a type I transmembrane protein involved in a variety of cellular processes such as cell adhesion and axon guidance. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24418459  15 ELVNLNVGGFKQSVDQSTLLRFPHTRLGKLLTChSEEAILELCDDysvADKEYYFDRNPSLFRYVLNF 82
Cdd:cd18398   3 EVVELNVGGQVYFTRHATLVSIPHSLLWKMFSP-KRDTANDLAKD---SKGRFFIDRDGFLFRYILDY 66

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 3 (KCTD3) and SH3KBP1-binding protein 1 (SHKBP1); The group of KCTD proteins includes KCTD3 and SHKBP1. KCTD3, also called renal carcinoma antigen NY-REN-45, is a BTB/POZ domain-containing protein that is an accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3), upregulating its cell-surface expression and current density without affecting its voltage dependence and kinetics. SHKBP1, also called SETA-binding protein 1, interacts with cathepsin B and participates in tumor necrosis factor (TNF)-induced apoptosis in ovarian cancer cells. It can promote epidermal growth factor receptor (EGFR) signaling by interrupting c-Cbl-CIN85 complex and inhibiting EGFR degradation. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24418459  15 ELVNLNVGGFKQSVDQSTLLRFPHTRLGKLLTCHseeaILELCDDYSvadkEYYFDRNPSLFRYVLNFYYTGKLHVmEEL 94
Cdd:cd18363   2 DIINLNVGGKRFSTSRQTLTWIPDSFFTSLLSGR----ISSLKDETG----AIFIDRDPKLFSIILNYLRTKEIDL-RNV 72

                        90
                ....*....|....
gi 24418459  95 CVFSFCQEIEYWGI 108
Cdd:cd18363  73 DISSLRHEAEFYGI 86

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 7 (KCTD7); KCTD7 is a BTB/POZ domain-containing protein that has an impact on K+ fluxes, neurotransmitter synthesis, and neuronal function. It functions as a regulator of potassium conductance in neurons, and is involved in the control of excitability of cortical neurons. Mutations in KCTD7 may cause progressive myoclonus epilepsy (PME). The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24418459  15 ELVNLNVGGFKQSVDQSTLLRFPHTRLGKLLTC-HseeailELCDDysvADKEYYFDRNPSLFRYVLNFYYTGKLHVMEE 93
Cdd:cd18366   4 EVVPLNVGGMHFTTRLSTLRKYEDSMLAAMFSGrH------HIPKD---SEGRYFIDRDGSYFGYILNFLRDGDLPPRER 74

                        90
                ....*....|....*...
gi 24418459  94 lcVFSFCQEIEYWGINEL 111
Cdd:cd18366  75 --ARAVYKEAQYYGIGPL 90

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in SH3KBP1-binding protein 1 (SHKBP1); SHKBP1, also called SETA-binding protein 1, interacts with cathepsin B and participates in tumor necrosis factor (TNF)-induced apoptosis in ovarian cancer cells. It can promote epidermal growth factor receptor (EGFR) signaling by interrupting c-Cbl-CIN85 complex and inhibiting EGFR degradation. It contains a BTB/POZ domain, also known as tetramerization (T1) domain, a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24418459  15 ELVNLNVGGFKQSVDQSTLLRFPHTRLGKLLTCHseeaILELCDDYSVAdkeyYFDRNPSLFRYVLNFYYTGKLHVmEEL 94
Cdd:cd18393   2 EVIHLNVGGKRFSTSRQTLTWIPDSFFSSLLSGR----ISTLKDETGAI----FIDRDPTVFAPILNFLRTKELDP-RGI 72

                        90
                ....*....|....*..
gi 24418459  95 CVFSFCQEIEYWGINEL 111
Cdd:cd18393  73 HVSLLLHEAQFYGITPL 89

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 14 (KCTD14); KCTD14 is a BTB/POZ domain-containing protein with unknown biological function. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels and others. Some KCTD proteins are involved in protein ubiquitination as part of the CRL (Cullin RING Ligase) E3 ligases. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24418459  16 LVNLNVGGFKQSVDQSTLLRFPHTRLGKLLTCHSEEAilelcddySVADKEYYFDRNPSLFRYVLNFYYTGKL 88
Cdd:cd18371   3 VVSLNVGGHIYTTTLSTLRKFPGSKLAELFNGQPKLR--------TDSEGRYFIDRDGTYFRYILEYLRTNQV 67

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 21 (KCTD21); KCTD21, also calledz KCTD containing, Cullin3 adaptor, suppressor of Hedgehog 2 (KCASH2), is a BTB/POZ domain-containing protein that functions as a substrate-specific adaptor of cullin-3, promoting the ubiquitination and degradation of histone deacetylase HDAC1, thereby inhibiting the deacetylation-mediated transcriptional activation of the Hedgehog effectors Gli1 and Gli2. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24418459  17 VNLNVGGFKQSVDQSTLLRFPHTRLGKLLTCHSEeailelcddySVADKE--YYFDRNPSLFRYVLNFYYTGKLHVMEEL 94
Cdd:cd18395   3 ITLNVGGKLYTTSLATLTRYPDSMLGAMFSGKFP----------TKKDSQgnCFIDRDGKIFRYILNFLRTSHLDLPEDF 72

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 17 (KCTD17); KCTD17 is a BTB/POZ domain-containing protein that functions as a substrate-adaptor for cullin3-RING ubiquitin ligases that polyubiquitylates trichoplein, a protein involved in ciliogenesis down-regulation. It is a positive regulator of ciliogenesis, playing a crucial role in the initial steps of axoneme extension. A missense mutation in KCTD17 causes autosomal dominant myoclonus-dystonia (M-D). The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD17 BTB domains form pentamers.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24418459  17 VNLNVGGFKQSVDQSTLLRFPHTRLGKLltCHSEEaiLELCDDYSVAdkeYYFDRNPSLFRYVLNFYYTGKLHVMEELCV 96
Cdd:cd18391   3 VRLNVGGTVFLTTRQTLCREQKSFLSRL--CQGEE--LQSDRDETGA---YLIDRDPTYFGPILNFLRHGKLVLDKDMAE 75

                        90
                ....*....|....*
gi 24418459  97 FSFCQEIEYWGINEL 111
Cdd:cd18391  76 EGVLEEAEFYNIGPL 90

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein KCTD8; KCTD8, a BTB/POZ domain-containing protein, is an auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. It interacts as a tetramer with GABRB1 and GABRB2. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24418459  15 ELVNLNVGGFKQSVDQSTLLRFPHTRLGKLLtchSEEAILELCDDysvADKEYYFDRNPSLFRYVLNFYYTGKL----HV 90
Cdd:cd18396   4 EVVELNVGGQVYVTKHSTLLSVPDSTLASMF---SRRAARELPRD---NRGRFFIDRDGFLFRYVLDYLRDKQLalpdHF 77

                        90       100
                ....*....|....*....|.
gi 24418459  91 MEELcvfSFCQEIEYWGINEL 111
Cdd:cd18396  78 PEKE---RLLREAEYFQLGDL 95