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Conserved domains on  [gi|145559530|sp|O75093|]
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RecName: Full=Slit homolog 1 protein; Short=Slit-1; AltName: Full=Multiple epidermal growth factor-like domains protein 4; Short=Multiple EGF-like domains protein 4; Flags: Precursor

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LamG smart00282
Laminin G domain;
1189-1322 7.56e-39

Laminin G domain;


:

Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 141.32  E-value: 7.56e-39
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530   1189 NITLQVSTAEDNGILLYNG---DNDHIAVELYQGHVRVSYDPGSYPSSAIYSAETINDGQFHTVELVAFDQMVNLSIDGG 1265
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGskgGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDGG 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 145559530   1266 SPMTMDNFGKHYTLNSEAPLYVGGMPVDvnsaaFRLWQILNGTGFHGCIRNLYINNE 1322
Cdd:smart00282   81 NRVSGESPGGLTILNLDGPLYLGGLPED-----LKLPPLPVTPGFRGCIRNLKVNGK 132
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
28-217 1.69e-29

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 123.12  E-value: 1.69e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530   28 RLGASACPALCTCTG-TTVDCHGTGLQAIPKNIPRNT--ERLELNGNNITRIHKnDFAGLKQLRVLQLMENQIGAVERgA 104
Cdd:COG4886   100 ELDLSGNEELSNLTNlESLDLSGNQLTDLPEELANLTnlKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPE-E 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  105 FDDMKELERLRLNRNQLHMLPELLfQNNQALSRLDLSENAIQAIPrKAFRGATDLKNLQLDKNQISCIEEgaFRALRGLE 184
Cdd:COG4886   178 LGNLTNLKELDLSNNQITDLPEPL-GNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTDLPE--LGNLTNLE 253

                         170       180       190
                  ....*....|....*....|....*....|...
gi 145559530  185 VLTLNNNNITTIPVSSfnHMPKLRTFRLHSNHL 217
Cdd:COG4886   254 ELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
522-820 4.33e-24

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 106.94  E-value: 4.33e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  522 NVVECSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFKKLTHLKKINLSNNKVSEIEDgAFEGAASVSELHLTANQL 601
Cdd:COG4886    70 SLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQL 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  602 ESIRSGmFRGLDGLRTLMLRNNRISCIhNDSFTGLRNVRLLSLYDNQITTVsPGAFDTLQSLSTLNLlanpfncncqlaw 681
Cdd:COG4886   149 TDLPEP-LGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDL------------- 212

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  682 lggwlrkrkivtgnprcqnpdflrqiplqdvafpdfrceegqeeggclprpqcpqecacldtvvrcSNKHLRALPKGIP- 760
Cdd:COG4886   213 ------------------------------------------------------------------SGNQLTDLPEPLAn 226

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 145559530  761 -KNVTELYLDGNQFTLVPgQLSTFKYLQLVDLSNNKISSLSNSSftNMSQLTTLILSYNAL 820
Cdd:COG4886   227 lTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQL 284
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 644-730 1.32e-12

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 73.19  E-value: 1.32e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530   644 LYDNQITTVSPGAFDTLQSLSTLNLLANPFNCNCQLAWLGGWLRKRKIVTGNPR---CQNPDFLRQIPLQDVAFPDFRCe 720
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEaalCAGPGALAGQPLLGIPLLDSGC- 80

                           90
                   ....*....|
gi 145559530   721 eGQEEGGCLP 730
Cdd:TIGR00864   81 -DEEYVACLK 89
LRR_8 pfam13855
Leucine rich repeat;
312-369 1.85e-11

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 60.62  E-value: 1.85e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 145559530   312 TEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKI 369
Cdd:pfam13855    4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 842-1002 4.73e-11

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 68.19  E-value: 4.73e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530   842 NDISTLQEGIFADVTSLSHLAIGANPLYCDCHLRWLSSWVK---TGYKEPGIARCAGPQDMEGKLLLTTPakkfecqgpp 918
Cdd:TIGR00864    5 NKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEekgVKVRQPEAALCAGPGALAGQPLLGIP---------- 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530   919 tlAVQAKCDL----CLssPCQNQGT-CHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGT----CHAQEGEDAPF 989
Cdd:TIGR00864   75 --LLDSGCDEeyvaCL--KDNSSGGgAARSELVIFSAAHEGLFQPEACNAFCFSAGHGLAALGEQgeclCGAAQPSEANF 150

                          170
                   ....*....|....*..
gi 145559530   990 T----CSCPTGFEGPTC 1002
Cdd:TIGR00864  151 AceslCSGPPPPPAAAC 167
LRR_8 pfam13855
Leucine rich repeat;
389-441 6.22e-09

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.68  E-value: 6.22e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 145559530   389 NANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPF 441
Cdd:pfam13855    9 SNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 188-328 7.03e-08

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 57.78  E-value: 7.03e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530   188 LNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQ------RPTIglfTQCSGPASLRGLNVAEVQKSEF 261
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEkgvkvrQPEA---ALCAGPGALAGQPLLGIPLLDS 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530   262 SC-----------SGQGEAGRVPTCTLSSG--------SCPAMC-TCSNGIVDCRGKGLTAIPANLPETMTEIRLELNGI 321
Cdd:TIGR00864   79 GCdeeyvaclkdnSSGGGAARSELVIFSAAheglfqpeACNAFCfSAGHGLAALGEQGECLCGAAQPSEANFACESLCSG 158


                   ....*..
gi 145559530   322 KSIPPGA 328
Cdd:TIGR00864  159 PPPPPAA 165
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1085-1119 1.48e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.09  E-value: 1.48e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 145559530 1085 DDCRD-HRCQNGAQCMDEVNSYSCLCAEGYSGQLCE 1119
Cdd:cd00054     3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1005-1041 6.12e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 6.12e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 145559530 1005 NTDDCVD-HACANGGVCVDGVGNYTCQCPLQYEGKACE 1041
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1044-1080 1.51e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 1.51e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 145559530 1044 VDLCSPDlNPCQHEAQCVGTPDGPRCECMPGYAGDNC 1080
Cdd:cd00054     2 IDECASG-NPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 412-475 2.23e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 49.31  E-value: 2.23e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 145559530   412 LYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICDCNLKWLADFLRTNPIET---SGARCASPRRLANK 475
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrqpEAALCAGPGALAGQ 68
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 733-760 1.70e-03

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


:

Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 37.22  E-value: 1.70e-03
                           10        20
                   ....*....|....*....|....*...
gi 145559530   733 QCPQECACLDTVVRCSNKHLRALPKGIP 760
Cdd:pfam01462    1 ACPVPCHCSATVVNCSDRGLTAVPRDLP 28
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1136-1163 3.20e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 3.20e-03
                          10        20
                  ....*....|....*....|....*...
gi 145559530 1136 CQNGANCVDQGNRPVCQCLPGFGGPECE 1163
Cdd:cd00054    11 CQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
 
Name Accession Description Interval E-value
LamG smart00282
Laminin G domain;
1189-1322 7.56e-39

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 141.32  E-value: 7.56e-39
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530   1189 NITLQVSTAEDNGILLYNG---DNDHIAVELYQGHVRVSYDPGSYPSSAIYSAETINDGQFHTVELVAFDQMVNLSIDGG 1265
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGskgGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDGG 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 145559530   1266 SPMTMDNFGKHYTLNSEAPLYVGGMPVDvnsaaFRLWQILNGTGFHGCIRNLYINNE 1322
Cdd:smart00282   81 NRVSGESPGGLTILNLDGPLYLGGLPED-----LKLPPLPVTPGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1167-1320 8.11e-38

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 139.09  E-value: 8.11e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530 1167 SVNFvDRDTYLQFTDLQN-WPRANITLQVSTAEDNGILLYNGD---NDHIAVELYQGHVRVSYDPGSypSSAIYSAET-I 1241
Cdd:cd00110     1 GVSF-SGSSYVRLPTLPApRTRLSISFSFRTTSPNGLLLYAGSqngGDFLALELEDGRLVLRYDLGS--GSLVLSSKTpL 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 145559530 1242 NDGQFHTVELVAFDQMVNLSIDGGSPMTMDNFGKHYTLNSEAPLYVGGMPVDVnsaafRLWQILNGTGFHGCIRNLYIN 1320
Cdd:cd00110    78 NDGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDL-----KSPGLPVSPGFVGCIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1194-1322 4.61e-35

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 130.23  E-value: 4.61e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  1194 VSTAEDNGILLYNGD--NDHIAVELYQGHVRVSYDPGSYPSSAIYSAETINDGQFHTVELVAFDQMVNLSIDGGSPMTMD 1271
Cdd:pfam02210    1 FRTRQPNGLLLYAGGggSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSSL 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 145559530  1272 NFGKHYTLNSEAPLYVGGMPVDVnsaafRLWQILNGTGFHGCIRNLYINNE 1322
Cdd:pfam02210   81 PPGESLLLNLNGPLYLGGLPPLL-----LLPALPVRAGFVGCIRDVRVNGE 126
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
28-217 1.69e-29

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 123.12  E-value: 1.69e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530   28 RLGASACPALCTCTG-TTVDCHGTGLQAIPKNIPRNT--ERLELNGNNITRIHKnDFAGLKQLRVLQLMENQIGAVERgA 104
Cdd:COG4886   100 ELDLSGNEELSNLTNlESLDLSGNQLTDLPEELANLTnlKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPE-E 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  105 FDDMKELERLRLNRNQLHMLPELLfQNNQALSRLDLSENAIQAIPrKAFRGATDLKNLQLDKNQISCIEEgaFRALRGLE 184
Cdd:COG4886   178 LGNLTNLKELDLSNNQITDLPEPL-GNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTDLPE--LGNLTNLE 253

                         170       180       190
                  ....*....|....*....|....*....|...
gi 145559530  185 VLTLNNNNITTIPVSSfnHMPKLRTFRLHSNHL 217
Cdd:COG4886   254 ELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
522-820 4.33e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 106.94  E-value: 4.33e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  522 NVVECSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFKKLTHLKKINLSNNKVSEIEDgAFEGAASVSELHLTANQL 601
Cdd:COG4886    70 SLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQL 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  602 ESIRSGmFRGLDGLRTLMLRNNRISCIhNDSFTGLRNVRLLSLYDNQITTVsPGAFDTLQSLSTLNLlanpfncncqlaw 681
Cdd:COG4886   149 TDLPEP-LGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDL------------- 212

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  682 lggwlrkrkivtgnprcqnpdflrqiplqdvafpdfrceegqeeggclprpqcpqecacldtvvrcSNKHLRALPKGIP- 760
Cdd:COG4886   213 ------------------------------------------------------------------SGNQLTDLPEPLAn 226

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 145559530  761 -KNVTELYLDGNQFTLVPgQLSTFKYLQLVDLSNNKISSLSNSSftNMSQLTTLILSYNAL 820
Cdd:COG4886   227 lTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQL 284
LRR_8 pfam13855
Leucine rich repeat;
590-649 1.08e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 67.16  E-value: 1.08e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530   590 SVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDNQI 649
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 644-730 1.32e-12

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 73.19  E-value: 1.32e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530   644 LYDNQITTVSPGAFDTLQSLSTLNLLANPFNCNCQLAWLGGWLRKRKIVTGNPR---CQNPDFLRQIPLQDVAFPDFRCe 720
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEaalCAGPGALAGQPLLGIPLLDSGC- 80

                           90
                   ....*....|
gi 145559530   721 eGQEEGGCLP 730
Cdd:TIGR00864   81 -DEEYVACLK 89
LRR_8 pfam13855
Leucine rich repeat;
159-217 1.81e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 63.70  E-value: 1.81e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 145559530   159 LKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHL 217
Cdd:pfam13855    3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
312-369 1.85e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 60.62  E-value: 1.85e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 145559530   312 TEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKI 369
Cdd:pfam13855    4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 842-1002 4.73e-11

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 68.19  E-value: 4.73e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530   842 NDISTLQEGIFADVTSLSHLAIGANPLYCDCHLRWLSSWVK---TGYKEPGIARCAGPQDMEGKLLLTTPakkfecqgpp 918
Cdd:TIGR00864    5 NKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEekgVKVRQPEAALCAGPGALAGQPLLGIP---------- 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530   919 tlAVQAKCDL----CLssPCQNQGT-CHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGT----CHAQEGEDAPF 989
Cdd:TIGR00864   75 --LLDSGCDEeyvaCL--KDNSSGGgAARSELVIFSAAHEGLFQPEACNAFCFSAGHGLAALGEQgeclCGAAQPSEANF 150

                          170
                   ....*....|....*..
gi 145559530   990 T----CSCPTGFEGPTC 1002
Cdd:TIGR00864  151 AceslCSGPPPPPAAAC 167
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 66-217 2.62e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 62.11  E-value: 2.62e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530   66 LELNGNNITRIhkNDFAGLKQLRVLQLMENQIGAVErgAFDDMKELERLRLNRNQLHMLPELlfQNNQALSRLDLSENAI 145
Cdd:cd21340     7 LYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKIENL--ENLVNLKKLYLGGNRI 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 145559530  146 QAIprKAFRGATDLKNLQLDKNQIS-----CIEEGAFRALRG-LEVLTLNNNNITTIpvSSFNHMPKLRTFRLHSNHL 217
Cdd:cd21340    81 SVV--EGLENLTNLEELHIENQRLPpgeklTFDPRSLAALSNsLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQI 154
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 530-673 3.58e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 61.73  E-value: 3.58e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  530 KLTKIP--ERIPQSTaELRLNNNEISILEatgMFKKLTHLKKINLSNNKVSEIEDgaFEGAASVSELHLTANQLES---- 603
Cdd:cd21340    35 KITKIEnlEFLTNLT-HLYLQNNQIEKIE---NLENLVNLKKLYLGGNRISVVEG--LENLTNLEELHIENQRLPPgekl 108

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 145559530  604 -IRSGMFRGL-DGLRTLMLRNNRISCIhnDSFTGLRNVRLLSLYDNQITTVSP--GAFDTLQSLSTLNLLANPF 673
Cdd:cd21340   109 tFDPRSLAALsNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPV 180
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
529-818 8.01e-10

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 63.56  E-value: 8.01e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  529 LKLTKIPERIPQSTAELRLNNNEISILEATGMfkklTHLKKINLSNNKVSEIEDGAFEgaaSVSELHLTANQLESIRSgm 608
Cdd:PRK15370  188 LGLTTIPACIPEQITTLILDNNELKSLPENLQ----GNIKTLYANSNQLTSIPATLPD---TIQEMELSINRITELPE-- 258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  609 fRGLDGLRTLMLRNNRISCIHNDSFTGLRNvrlLSLYDNQITTVsPGAFDTlqSLSTLNLLANpfncncQLAWLGGWLrk 688
Cdd:PRK15370  259 -RLPSALQSLDLFHNKISCLPENLPEELRY---LSVYDNSIRTL-PAHLPS--GITHLNVQSN------SLTALPETL-- 323

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  689 rkivtgnprcqnPDFLRQIPLQDVAFPdfrceegqeeggCLPRpQCPQECACLDTvvrcSNKHLRALPKGIPKNVTELYL 768
Cdd:PRK15370  324 ------------PPGLKTLEAGENALT------------SLPA-SLPPELQVLDV----SKNQITVLPETLPPTITTLDV 374

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 145559530  769 DGNQFTLVPGQLSTfkYLQLVDLSNNKISSLSNS--SFTNMS-QLTTLILSYN 818
Cdd:PRK15370  375 SRNALTNLPENLPA--ALQIMQASRNNLVRLPESlpHFRGEGpQPTRIIVEYN 425
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 131-671 2.34e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 62.17  E-value: 2.34e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  131 NNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISC-IEEGAFRALRGLEVLTLNNNNIT-TIPVSSfnhMPKLR 208
Cdd:PLN00113   67 NSSRVVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSGpIPDDIFTTSSSLRYLNLSNNNFTgSIPRGS---IPNLE 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  209 TFRLHSNHLFCDCHLawlsqwlrqrpTIGLFTqcsgpaSLRGLNVAevqksefscsGQGEAGRVPTCTLSSGSCPAMCTC 288
Cdd:PLN00113  144 TLDLSNNMLSGEIPN-----------DIGSFS------SLKVLDLG----------GNVLVGKIPNSLTNLTSLEFLTLA 196

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  289 SNGIVDcrgkgltAIPANLPE--TMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYG 366
Cdd:PLN00113  197 SNQLVG-------QIPRELGQmkSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQ 269

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  367 NKITD-LPRGVFGgLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICDC 445
Cdd:PLN00113  270 NKLSGpIPPSIFS-LQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEI 348

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  446 --------NLKWLAdfLRTNPI--ETSGARCASPR-----RLANKRIGQIKSKKFRCSAKEQYFIpgtEDYQLNSECNSD 510
Cdd:PLN00113  349 pknlgkhnNLTVLD--LSTNNLtgEIPEGLCSSGNlfkliLFSNSLEGEIPKSLGACRSLRRVRL---QDNSFSGELPSE 423

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  511 vvcphkcrceanvvecsslkLTKIPeripqSTAELRLNNNEISILEATGMFkKLTHLKKINLSNNKVS-EIEDgaFEGAA 589
Cdd:PLN00113  424 --------------------FTKLP-----LVYFLDISNNNLQGRINSRKW-DMPSLQMLSLARNKFFgGLPD--SFGSK 475

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  590 SVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLL 669
Cdd:PLN00113  476 RLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLS 555


                  ..
gi 145559530  670 AN 671
Cdd:PLN00113  556 QN 557
LRR_8 pfam13855
Leucine rich repeat;
389-441 6.22e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.68  E-value: 6.22e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 145559530   389 NANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPF 441
Cdd:pfam13855    9 SNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 55-217 1.06e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 60.25  E-value: 1.06e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530   55 IPKNIP--RNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQI-GAVERGAFDdMKELERLRLNRNQ-LHMLPELLFQ 130
Cdd:PLN00113  396 IPKSLGacRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLqGRINSRKWD-MPSLQMLSLARNKfFGGLPDSFGS 474

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  131 NNqaLSRLDLSENAIQ-AIPRKaFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNIT-TIPvSSFNHMPKLR 208
Cdd:PLN00113  475 KR--LENLDLSRNQFSgAVPRK-LGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSgQIP-ASFSEMPVLS 550


                  ....*....
gi 145559530  209 TFRLHSNHL 217
Cdd:PLN00113  551 QLDLSQNQL 559
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 188-328 7.03e-08

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 57.78  E-value: 7.03e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530   188 LNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQ------RPTIglfTQCSGPASLRGLNVAEVQKSEF 261
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEkgvkvrQPEA---ALCAGPGALAGQPLLGIPLLDS 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530   262 SC-----------SGQGEAGRVPTCTLSSG--------SCPAMC-TCSNGIVDCRGKGLTAIPANLPETMTEIRLELNGI 321
Cdd:TIGR00864   79 GCdeeyvaclkdnSSGGGAARSELVIFSAAheglfqpeACNAFCfSAGHGLAALGEQGECLCGAAQPSEANFACESLCSG 158


                   ....*..
gi 145559530   322 KSIPPGA 328
Cdd:TIGR00864  159 PPPPPAA 165
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1085-1119 1.48e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.09  E-value: 1.48e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 145559530 1085 DDCRD-HRCQNGAQCMDEVNSYSCLCAEGYSGQLCE 1119
Cdd:cd00054     3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
LRRCT smart00082
Leucine rich repeat C-terminal domain;
866-915 5.59e-06

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 44.73  E-value: 5.59e-06
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 145559530    866 NPLYCDCHLRWLSSWV--KTGYKEPGIARCAGPQDMEGKLLLTTPAkKFECQ 915
Cdd:smart00082    1 NPFICDCELRWLLRWLqaNEHLQDPVDLRCASPSSLRGPLLELLHS-EFKCP 51
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1005-1041 6.12e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 6.12e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 145559530 1005 NTDDCVD-HACANGGVCVDGVGNYTCQCPLQYEGKACE 1041
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
LRRNT smart00013
Leucine rich repeat N-terminal domain;
33-64 1.22e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 43.46  E-value: 1.22e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 145559530     33 ACPALCTCTGTTVDCHGTGLQAIPKNIPRNTE 64
Cdd:smart00013    1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1044-1080 1.51e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 1.51e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 145559530 1044 VDLCSPDlNPCQHEAQCVGTPDGPRCECMPGYAGDNC 1080
Cdd:cd00054     2 IDECASG-NPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 412-475 2.23e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 49.31  E-value: 2.23e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 145559530   412 LYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICDCNLKWLADFLRTNPIET---SGARCASPRRLANK 475
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrqpEAALCAGPGALAGQ 68
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
296-373 2.49e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 48.92  E-value: 2.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  296 RGKGLTAIPANLPETMTEIRLELNGIKSIP---PGAfspyrkLRRIDLSNNQIAEIAPDAFQGLRSLNslvLYGNKITDL 372
Cdd:PRK15370  228 NSNQLTSIPATLPDTIQEMELSINRITELPerlPSA------LQSLDLFHNKISCLPENLPEELRYLS---VYDNSIRTL 298


                  .
gi 145559530  373 P 373
Cdd:PRK15370  299 P 299
LRRCT smart00082
Leucine rich repeat C-terminal domain;
671-719 4.71e-05

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 42.42  E-value: 4.71e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|.
gi 145559530    671 NPFNCNCQLAWLGGWLRKRKIV--TGNPRCQNPDFLRQiPLQDVAFPDFRC 719
Cdd:smart00082    1 NPFICDCELRWLLRWLQANEHLqdPVDLRCASPSSLRG-PLLELLHSEFKC 50
LRRNT smart00013
Leucine rich repeat N-terminal domain;
282-313 5.20e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 41.53  E-value: 5.20e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 145559530    282 CPAMCTCSNGIVDCRGKGLTAIPANLPETMTE 313
Cdd:smart00013    2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 282-308 5.23e-05

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 41.46  E-value: 5.23e-05
                           10        20
                   ....*....|....*....|....*..
gi 145559530   282 CPAMCTCSNGIVDCRGKGLTAIPANLP 308
Cdd:pfam01462    2 CPVPCHCSATVVNCSDRGLTAVPRDLP 28
EGF_CA smart00179
Calcium-binding EGF-like domain;
1085-1119 5.94e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.46  E-value: 5.94e-05
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 145559530   1085 DDC-RDHRCQNGAQCMDEVNSYSCLCAEGYS-GQLCE 1119
Cdd:smart00179    3 DECaSGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 114-374 8.55e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.55  E-value: 8.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  114 LRLNRNQLHMLPEL-LFQNnqaLSRLDLSENAIQAIPrkAFRGATDLKNLQLDKNQISCIEEgaFRALRGLEVLTLNNNN 192
Cdd:cd21340     7 LYLNDKNITKIDNLsLCKN---LKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  193 ITTipVSSFNHMPKLRTfrLHsnhlfcdchlawLSqwlRQRPTIGlFTQCSGPASLRGLnvaevqksefSCSGQgeagrv 272
Cdd:cd21340    80 ISV--VEGLENLTNLEE--LH------------IE---NQRLPPG-EKLTFDPRSLAAL----------SNSLR------ 123

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  273 ptctlssgscpamctcsngIVDCRGkgltaipanlpetmteirlelNGIKSIPPgaFSPYRKLRRIDLSNNQIAEIAP-- 350
Cdd:cd21340   124 -------------------VLNISG---------------------NNIDSLEP--LAPLRNLEQLDASNNQISDLEEll 161

                         250       260
                  ....*....|....*....|....
gi 145559530  351 DAFQGLRSLNSLVLYGNKITDLPR 374
Cdd:cd21340   162 DLLSSWPSLRELDLTGNPVCKKPK 185
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1087-1115 1.62e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.06  E-value: 1.62e-04
                           10        20
                   ....*....|....*....|....*....
gi 145559530  1087 CRDHRCQNGAQCMDEVNSYSCLCAEGYSG 1115
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
LRRNT smart00013
Leucine rich repeat N-terminal domain;
733-765 1.66e-04

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 40.38  E-value: 1.66e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 145559530    733 QCPQECACLDTVVRCSNKHLRALPKGIPKNVTE 765
Cdd:smart00013    1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 927-962 1.69e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 1.69e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 145559530  927 DLCLS-SPCQNQGTCHNDPlEVYRCACPSGYKGRDCE 962
Cdd:cd00054     3 DECASgNPCQNGGTCVNTV-GSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
1005-1041 1.73e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 1.73e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 145559530   1005 NTDDCV-DHACANGGVCVDGVGNYTCQCPLQYE-GKACE 1041
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
LRRCT smart00082
Leucine rich repeat C-terminal domain;
439-469 3.30e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 39.72  E-value: 3.30e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 145559530    439 NPFICDCNLKWLADFLRTNPI--ETSGARCASP 469
Cdd:smart00082    1 NPFICDCELRWLLRWLQANEHlqDPVDLRCASP 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1044-1080 7.08e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 7.08e-04
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 145559530   1044 VDLCSPDlNPCQHEAQCVGTPDGPRCECMPGY-AGDNC 1080
Cdd:smart00179    2 IDECASG-NPCQNGGTCVNTVGSYRCECPPGYtDGRNC 38
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 733-760 1.70e-03

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 37.22  E-value: 1.70e-03
                           10        20
                   ....*....|....*....|....*...
gi 145559530   733 QCPQECACLDTVVRCSNKHLRALPKGIP 760
Cdd:pfam01462    1 ACPVPCHCSATVVNCSDRGLTAVPRDLP 28
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1009-1038 2.19e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.98  E-value: 2.19e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 145559530  1009 CVDHACANGGVCVDGVGNYTCQCPLQYEGK 1038
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1136-1163 3.20e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 3.20e-03
                          10        20
                  ....*....|....*....|....*...
gi 145559530 1136 CQNGANCVDQGNRPVCQCLPGFGGPECE 1163
Cdd:cd00054    11 CQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 929-960 4.71e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.21  E-value: 4.71e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 145559530   929 CLSSPCQNQGTCHNDPlEVYRCACPSGYKGRD 960
Cdd:pfam00008    1 CAPNPCSNGGTCVDTP-GGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1050-1079 7.05e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.44  E-value: 7.05e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 145559530  1050 DLNPCQHEAQCVGTPDGPRCECMPGYAGDN 1079
Cdd:pfam00008    2 APNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
 
Name Accession Description Interval E-value
LamG smart00282
Laminin G domain;
1189-1322 7.56e-39

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 141.32  E-value: 7.56e-39
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530   1189 NITLQVSTAEDNGILLYNG---DNDHIAVELYQGHVRVSYDPGSYPSSAIYSAETINDGQFHTVELVAFDQMVNLSIDGG 1265
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGskgGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDGG 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 145559530   1266 SPMTMDNFGKHYTLNSEAPLYVGGMPVDvnsaaFRLWQILNGTGFHGCIRNLYINNE 1322
Cdd:smart00282   81 NRVSGESPGGLTILNLDGPLYLGGLPED-----LKLPPLPVTPGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1167-1320 8.11e-38

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 139.09  E-value: 8.11e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530 1167 SVNFvDRDTYLQFTDLQN-WPRANITLQVSTAEDNGILLYNGD---NDHIAVELYQGHVRVSYDPGSypSSAIYSAET-I 1241
Cdd:cd00110     1 GVSF-SGSSYVRLPTLPApRTRLSISFSFRTTSPNGLLLYAGSqngGDFLALELEDGRLVLRYDLGS--GSLVLSSKTpL 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 145559530 1242 NDGQFHTVELVAFDQMVNLSIDGGSPMTMDNFGKHYTLNSEAPLYVGGMPVDVnsaafRLWQILNGTGFHGCIRNLYIN 1320
Cdd:cd00110    78 NDGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDL-----KSPGLPVSPGFVGCIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1194-1322 4.61e-35

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 130.23  E-value: 4.61e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  1194 VSTAEDNGILLYNGD--NDHIAVELYQGHVRVSYDPGSYPSSAIYSAETINDGQFHTVELVAFDQMVNLSIDGGSPMTMD 1271
Cdd:pfam02210    1 FRTRQPNGLLLYAGGggSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSSL 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 145559530  1272 NFGKHYTLNSEAPLYVGGMPVDVnsaafRLWQILNGTGFHGCIRNLYINNE 1322
Cdd:pfam02210   81 PPGESLLLNLNGPLYLGGLPPLL-----LLPALPVRAGFVGCIRDVRVNGE 126
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
28-217 1.69e-29

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 123.12  E-value: 1.69e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530   28 RLGASACPALCTCTG-TTVDCHGTGLQAIPKNIPRNT--ERLELNGNNITRIHKnDFAGLKQLRVLQLMENQIGAVERgA 104
Cdd:COG4886   100 ELDLSGNEELSNLTNlESLDLSGNQLTDLPEELANLTnlKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPE-E 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  105 FDDMKELERLRLNRNQLHMLPELLfQNNQALSRLDLSENAIQAIPrKAFRGATDLKNLQLDKNQISCIEEgaFRALRGLE 184
Cdd:COG4886   178 LGNLTNLKELDLSNNQITDLPEPL-GNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTDLPE--LGNLTNLE 253

                         170       180       190
                  ....*....|....*....|....*....|...
gi 145559530  185 VLTLNNNNITTIPVSSfnHMPKLRTFRLHSNHL 217
Cdd:COG4886   254 ELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQL 284
Laminin_G_1 pfam00054
Laminin G domain;
1194-1325 1.19e-28

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 112.03  E-value: 1.19e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  1194 VSTAEDNGILLYNGDNDH---IAVELYQGHVRVSYDPGSYPSSaIYSAETINDGQFHTVELVAFDQMVNLSIDGG-SPMT 1269
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTErdfLALELRDGRLEVSYDLGSGAAV-VRSGDKLNDGKWHSVELERNGRSGTLSVDGEaRPTG 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 145559530  1270 MDNFGKHYTLNSEAPLYVGGMPVDVNSAafrlWQILNGTGFHGCIRNLYINNELQD 1325
Cdd:pfam00054   80 ESPLGATTDLDVDGPLYVGGLPSLGVKK----RRLAISPSFDGCIRDVIVNGKPLD 131
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
522-820 4.33e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 106.94  E-value: 4.33e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  522 NVVECSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFKKLTHLKKINLSNNKVSEIEDgAFEGAASVSELHLTANQL 601
Cdd:COG4886    70 SLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQL 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  602 ESIRSGmFRGLDGLRTLMLRNNRISCIhNDSFTGLRNVRLLSLYDNQITTVsPGAFDTLQSLSTLNLlanpfncncqlaw 681
Cdd:COG4886   149 TDLPEP-LGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDL------------- 212

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  682 lggwlrkrkivtgnprcqnpdflrqiplqdvafpdfrceegqeeggclprpqcpqecacldtvvrcSNKHLRALPKGIP- 760
Cdd:COG4886   213 ------------------------------------------------------------------SGNQLTDLPEPLAn 226

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 145559530  761 -KNVTELYLDGNQFTLVPgQLSTFKYLQLVDLSNNKISSLSNSSftNMSQLTTLILSYNAL 820
Cdd:COG4886   227 lTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
545-827 3.02e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 104.25  E-value: 3.02e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  545 LRLNNNEISILEATGMFKKLTHLKKINLSNNKvseiedgAFEGAASVSELHLTANQLESIrSGMFRGLDGLRTLMLRNNR 624
Cdd:COG4886    76 LLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQ 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  625 ISCIhNDSFTGLRNVRLLSLYDNQITTVsPGAFDTLQSLSTLNLlanpfncncqlawlggwlrkrkivtgnprcqnpdfl 704
Cdd:COG4886   148 LTDL-PEPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDL------------------------------------ 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  705 rqiplqdvafpdfrceegqeeggclprpqcpqecacldtvvrcSNKHLRALPKGI--PKNVTELYLDGNQFTLVPGQLST 782
Cdd:COG4886   190 -------------------------------------------SNNQITDLPEPLgnLTNLEELDLSGNQLTDLPEPLAN 226

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 145559530  783 FKYLQLVDLSNNKISSLsnSSFTNMSQLTTLILSYNALQCIPPLA 827
Cdd:COG4886   227 LTNLETLDLSNNQLTDL--PELGNLTNLEELDLSNNQLTDLPPLA 269
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
55-456 3.63e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 104.25  E-value: 3.63e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530   55 IPKNIPRNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQigavergAFDDMKELERLRLNRNQLHMLPELLfQNNQA 134
Cdd:COG4886    66 LLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPEEL-ANLTN 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  135 LSRLDLSENAIQAIPrKAFRGATDLKNLQLDKNQISCIEEgAFRALRGLEVLTLNNNNITTIPvSSFNHMPKLRTFRLHS 214
Cdd:COG4886   138 LKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSG 214

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  215 NHLFcdchlawlsqwlrqrpTIglftqcsgPASLRGLNvaevqksefscsgqgeagrvptcTLSSgscpamctcsngiVD 294
Cdd:COG4886   215 NQLT----------------DL--------PEPLANLT-----------------------NLET-------------LD 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  295 CRGKGLTAIP--ANLPEtMTEIRLELNGIKSIPPGAFSPyrKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDL 372
Cdd:COG4886   235 LSNNQLTDLPelGNLTN-LEELDLSNNQLTDLPPLANLT--NLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLL 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  373 PrgVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICDCNLKWLAD 452
Cdd:COG4886   312 E--LLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTL 389


                  ....
gi 145559530  453 FLRT 456
Cdd:COG4886   390 LLLL 393
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
106-484 2.64e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 98.47  E-value: 2.64e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  106 DDMKELERLRLNRNQLHMLPELLFQNNQALSRLDLSENaiqaiprKAFRGATDLKNLQLDKNQISCIEEgAFRALRGLEV 185
Cdd:COG4886    69 LSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKE 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  186 LTLNNNNITTIPvSSFNHMPKLRTFRLHSNHLfcdchlawlsqwlrqrptIGLftqcsgPASLRGLNvaevqksefscsg 265
Cdd:COG4886   141 LDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQL------------------TDL------PEELGNLT------------- 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  266 qgeagrvptctlssgscpamctcsngivdcrgkgltaipaNLpetmTEIRLELNGIKSIPPgAFSPYRKLRRIDLSNNQI 345
Cdd:COG4886   183 ----------------------------------------NL----KELDLSNNQITDLPE-PLGNLTNLEELDLSGNQL 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  346 AEIaPDAFQGLRSLNSLVLYGNKITDLPrgvfgglytlqllllnankincirpdAFQDLQNLSLLSLYDNKIQSLakGTF 425
Cdd:COG4886   218 TDL-PEPLANLTNLETLDLSNNQLTDLP--------------------------ELGNLTNLEELDLSNNQLTDL--PPL 268

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 145559530  426 TSLRAIQTLHLAQNPfICDCNLKWLADFLRTNPIETSGARCASPRRLANKRIGQIKSKK 484
Cdd:COG4886   269 ANLTNLKTLDLSNNQ-LTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLL 326
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
544-826 7.05e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 97.31  E-value: 7.05e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  544 ELRLNNNEISILEATgmFKKLTHLKKINLSNNKVSEIEDgAFEGAASVSELHLTANQLESIRSGmFRGLDGLRTLMLRNN 623
Cdd:COG4886   117 SLDLSGNQLTDLPEE--LANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNN 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  624 RISCIHnDSFTGLRNVRLLSLYDNQITTVsPGAFDTLQSLSTLNLLANPFNcncQLAWLGGWlrkrkivtgnprcqnpdf 703
Cdd:COG4886   193 QITDLP-EPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLT---DLPELGNL------------------ 249

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  704 lrqiplqdvafpdfrceegqeeggclprpqcpqecacldtvvrcsnkhlralpkgipKNVTELYLDGNQFTLVPgQLSTF 783
Cdd:COG4886   250 ---------------------------------------------------------TNLEELDLSNNQLTDLP-PLANL 271

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 145559530  784 KYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPL 826
Cdd:COG4886   272 TNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELL 314
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
303-679 9.95e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 96.93  E-value: 9.95e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  303 IPANLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNqiaeiapDAFQGLRSLNSLVLYGNKITDLPrgvfgglyt 382
Cdd:COG4886    66 LLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLP--------- 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  383 lqllllnankincirpDAFQDLQNLSLLSLYDNKIQSLAKgTFTSLRAIQTLHLAQNpficdcnlkwladflrtnpiets 462
Cdd:COG4886   130 ----------------EELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNN----------------------- 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  463 garcasprrlankrigQIKSkkfrcsakeqyfIPgtedyqlnsecnsdvvcphkcrceANVVECSSLKltkiperipqst 542
Cdd:COG4886   170 ----------------QLTD------------LP------------------------EELGNLTNLK------------ 185

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  543 aELRLNNNEISILEATgmFKKLTHLKKINLSNNKVSEIEDgAFEGAASVSELHLTANQLESIRSgmFRGLDGLRTLMLRN 622
Cdd:COG4886   186 -ELDLSNNQITDLPEP--LGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSN 259

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 145559530  623 NRISCIhnDSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFNCNCQL 679
Cdd:COG4886   260 NQLTDL--PPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELL 314
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
315-674 7.28e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 94.23  E-value: 7.28e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  315 RLELNGIKSIppgafSPYRKLRRIDLSNNQIAEIaPDAFQGLRSLNSLVLYGNKITDLprgvfgglytlqllllnankin 394
Cdd:COG4886   100 ELDLSGNEEL-----SNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDL---------------------- 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  395 cirPDAFQDLQNLSLLSLYDNKIQSLAKgtftslrAIQTLHlaqnpficdcNLKWLadFLRTNPIETsgarcasprrlan 474
Cdd:COG4886   152 ---PEPLGNLTNLKSLDLSNNQLTDLPE-------ELGNLT----------NLKEL--DLSNNQITD------------- 196

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  475 krigqikskkfrcsakeqyfIPGTedyqlnsecnsdvvcphkcrceanVVECSSLKltkiperipqstaELRLNNNEISI 554
Cdd:COG4886   197 --------------------LPEP------------------------LGNLTNLE-------------ELDLSGNQLTD 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  555 LEATgmFKKLTHLKKINLSNNKVSEIEDgaFEGAASVSELHLTANQLESIRSGMfrGLDGLRTLMLRNNRISCIHNDSFT 634
Cdd:COG4886   220 LPEP--LANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELE 293

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 145559530  635 GLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFN 674
Cdd:COG4886   294 LLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGL 333
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
312-674 2.64e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 92.30  E-value: 2.64e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  312 TEIRLELNGIKSIPPgAFSPYRKLRRIDLSNNQIAEIaPDAFQGLRSLNSLVLYGNKITDLPrgvfgglytlqllllnan 391
Cdd:COG4886   116 ESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLP------------------ 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  392 kincirpDAFQDLQNLSLLSLYDNKIQSLAKgTFTSLRAIQTLHLAQNpficdcnlkwladflrtnpietsgarcasprr 471
Cdd:COG4886   176 -------EELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGN-------------------------------- 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  472 lankrigqikskkfrcsakeqyfipgtedyqlnsecnsdvvcphkcrceanvvecsslKLTKIPERIPQSTA--ELRLNN 549
Cdd:COG4886   216 ----------------------------------------------------------QLTDLPEPLANLTNleTLDLSN 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  550 NEISILEAtgmFKKLTHLKKINLSNNKVSEIEDGAfeGAASVSELHLTANQLESIR----SGMFRGLDGLRTLMLRNNRI 625
Cdd:COG4886   238 NQLTDLPE---LGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKlkelELLLGLNSLLLLLLLLNLLE 312

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 145559530  626 SCIHNDSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFN 674
Cdd:COG4886   313 LLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSL 361
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
743-868 1.48e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 80.75  E-value: 1.48e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  743 TVVRCSNKHLRALPKGIP--KNVTELYLDGNQFTLVPGQLSTFKYLQLVDLSNNKISSLSnSSFTNMSQLTTLILSYNAL 820
Cdd:COG4886   116 ESLDLSGNQLTDLPEELAnlTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQI 194

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 145559530  821 QCIPPlAFQGLRSLRLLSLHGNDISTLQEGIfADVTSLSHLAIGANPL 868
Cdd:COG4886   195 TDLPE-PLGNLTNLEELDLSGNQLTDLPEPL-ANLTNLETLDLSNNQL 240
LRR_8 pfam13855
Leucine rich repeat;
590-649 1.08e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 67.16  E-value: 1.08e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530   590 SVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDNQI 649
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
614-673 2.01e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 66.39  E-value: 2.01e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530   614 GLRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPF 673
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
43-203 2.71e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 73.81  E-value: 2.71e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530   43 TTVDCHGTGLQAIPKNIPRNT--ERLELNGNNITRIhKNDFAGLKQLRVLQLMENQIGAVErgAFDDMKELERLRLNRNQ 120
Cdd:COG4886   185 KELDLSNNQITDLPEPLGNLTnlEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQ 261

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  121 LHMLPELLfqNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEgaFRALRGLEVLTLNNNNITTIPVSS 200
Cdd:COG4886   262 LTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLEL--LILLLLLTTLLLLLLLLKGLLVTL 337


                  ...
gi 145559530  201 FNH 203
Cdd:COG4886   338 TTL 340
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 644-730 1.32e-12

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 73.19  E-value: 1.32e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530   644 LYDNQITTVSPGAFDTLQSLSTLNLLANPFNCNCQLAWLGGWLRKRKIVTGNPR---CQNPDFLRQIPLQDVAFPDFRCe 720
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEaalCAGPGALAGQPLLGIPLLDSGC- 80

                           90
                   ....*....|
gi 145559530   721 eGQEEGGCLP 730
Cdd:TIGR00864   81 -DEEYVACLK 89
LRR_8 pfam13855
Leucine rich repeat;
159-217 1.81e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 63.70  E-value: 1.81e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 145559530   159 LKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHL 217
Cdd:pfam13855    3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
761-868 6.02e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 69.58  E-value: 6.02e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  761 KNVTELYLDGNQFTLVPGQLSTFKYLQLVDLSNNKISSLSnSSFTNMSQLTTLILSYNALQCIPPlAFQGLRSLRLLSLH 840
Cdd:COG4886   113 TNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLS 190

                          90       100
                  ....*....|....*....|....*...
gi 145559530  841 GNDISTLQEGIfADVTSLSHLAIGANPL 868
Cdd:COG4886   191 NNQITDLPEPL-GNLTNLEELDLSGNQL 217
LRR_8 pfam13855
Leucine rich repeat;
565-625 6.12e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 62.16  E-value: 6.12e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 145559530   565 THLKKINLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRI 625
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
135-193 1.12e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.39  E-value: 1.12e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 145559530   135 LSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNI 193
Cdd:pfam13855    3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
312-369 1.85e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 60.62  E-value: 1.85e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 145559530   312 TEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKI 369
Cdd:pfam13855    4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
61-121 4.16e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.85  E-value: 4.16e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 145559530    61 RNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQL 121
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 842-1002 4.73e-11

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 68.19  E-value: 4.73e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530   842 NDISTLQEGIFADVTSLSHLAIGANPLYCDCHLRWLSSWVK---TGYKEPGIARCAGPQDMEGKLLLTTPakkfecqgpp 918
Cdd:TIGR00864    5 NKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEekgVKVRQPEAALCAGPGALAGQPLLGIP---------- 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530   919 tlAVQAKCDL----CLssPCQNQGT-CHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGT----CHAQEGEDAPF 989
Cdd:TIGR00864   75 --LLDSGCDEeyvaCL--KDNSSGGgAARSELVIFSAAHEGLFQPEACNAFCFSAGHGLAALGEQgeclCGAAQPSEANF 150

                          170
                   ....*....|....*..
gi 145559530   990 T----CSCPTGFEGPTC 1002
Cdd:TIGR00864  151 AceslCSGPPPPPAAAC 167
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 66-217 2.62e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 62.11  E-value: 2.62e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530   66 LELNGNNITRIhkNDFAGLKQLRVLQLMENQIGAVErgAFDDMKELERLRLNRNQLHMLPELlfQNNQALSRLDLSENAI 145
Cdd:cd21340     7 LYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKIENL--ENLVNLKKLYLGGNRI 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 145559530  146 QAIprKAFRGATDLKNLQLDKNQIS-----CIEEGAFRALRG-LEVLTLNNNNITTIpvSSFNHMPKLRTFRLHSNHL 217
Cdd:cd21340    81 SVV--EGLENLTNLEELHIENQRLPpgeklTFDPRSLAALSNsLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQI 154
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 530-673 3.58e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 61.73  E-value: 3.58e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  530 KLTKIP--ERIPQSTaELRLNNNEISILEatgMFKKLTHLKKINLSNNKVSEIEDgaFEGAASVSELHLTANQLES---- 603
Cdd:cd21340    35 KITKIEnlEFLTNLT-HLYLQNNQIEKIE---NLENLVNLKKLYLGGNRISVVEG--LENLTNLEELHIENQRLPPgekl 108

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 145559530  604 -IRSGMFRGL-DGLRTLMLRNNRISCIhnDSFTGLRNVRLLSLYDNQITTVSP--GAFDTLQSLSTLNLLANPF 673
Cdd:cd21340   109 tFDPRSLAALsNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPV 180
LRR_8 pfam13855
Leucine rich repeat;
333-417 5.08e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 56.76  E-value: 5.08e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530   333 RKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITdlprgvfgglytlqllllnankinCIRPDAFQDLQNLSLLSL 412
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT------------------------TLSPGAFSGLPSLRYLDL 56


                   ....*
gi 145559530   413 YDNKI 417
Cdd:pfam13855   57 SGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
529-818 8.01e-10

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 63.56  E-value: 8.01e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  529 LKLTKIPERIPQSTAELRLNNNEISILEATGMfkklTHLKKINLSNNKVSEIEDGAFEgaaSVSELHLTANQLESIRSgm 608
Cdd:PRK15370  188 LGLTTIPACIPEQITTLILDNNELKSLPENLQ----GNIKTLYANSNQLTSIPATLPD---TIQEMELSINRITELPE-- 258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  609 fRGLDGLRTLMLRNNRISCIHNDSFTGLRNvrlLSLYDNQITTVsPGAFDTlqSLSTLNLLANpfncncQLAWLGGWLrk 688
Cdd:PRK15370  259 -RLPSALQSLDLFHNKISCLPENLPEELRY---LSVYDNSIRTL-PAHLPS--GITHLNVQSN------SLTALPETL-- 323

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  689 rkivtgnprcqnPDFLRQIPLQDVAFPdfrceegqeeggCLPRpQCPQECACLDTvvrcSNKHLRALPKGIPKNVTELYL 768
Cdd:PRK15370  324 ------------PPGLKTLEAGENALT------------SLPA-SLPPELQVLDV----SKNQITVLPETLPPTITTLDV 374

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 145559530  769 DGNQFTLVPGQLSTfkYLQLVDLSNNKISSLSNS--SFTNMS-QLTTLILSYN 818
Cdd:PRK15370  375 SRNALTNLPENLPA--ALQIMQASRNNLVRLPESlpHFRGEGpQPTRIIVEYN 425
LRR_8 pfam13855
Leucine rich repeat;
544-601 1.35e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.22  E-value: 1.35e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 145559530   544 ELRLNNNEISILEAtGMFKKLTHLKKINLSNNKVSEIEDGAFEGAASVSELHLTANQL 601
Cdd:pfam13855    5 SLDLSNNRLTSLDD-GAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
762-820 1.72e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.22  E-value: 1.72e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530   762 NVTELYLDGNQFTLV-PGQLSTFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNAL 820
Cdd:pfam13855    2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 131-671 2.34e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 62.17  E-value: 2.34e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  131 NNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISC-IEEGAFRALRGLEVLTLNNNNIT-TIPVSSfnhMPKLR 208
Cdd:PLN00113   67 NSSRVVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSGpIPDDIFTTSSSLRYLNLSNNNFTgSIPRGS---IPNLE 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  209 TFRLHSNHLFCDCHLawlsqwlrqrpTIGLFTqcsgpaSLRGLNVAevqksefscsGQGEAGRVPTCTLSSGSCPAMCTC 288
Cdd:PLN00113  144 TLDLSNNMLSGEIPN-----------DIGSFS------SLKVLDLG----------GNVLVGKIPNSLTNLTSLEFLTLA 196

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  289 SNGIVDcrgkgltAIPANLPE--TMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYG 366
Cdd:PLN00113  197 SNQLVG-------QIPRELGQmkSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQ 269

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  367 NKITD-LPRGVFGgLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICDC 445
Cdd:PLN00113  270 NKLSGpIPPSIFS-LQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEI 348

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  446 --------NLKWLAdfLRTNPI--ETSGARCASPR-----RLANKRIGQIKSKKFRCSAKEQYFIpgtEDYQLNSECNSD 510
Cdd:PLN00113  349 pknlgkhnNLTVLD--LSTNNLtgEIPEGLCSSGNlfkliLFSNSLEGEIPKSLGACRSLRRVRL---QDNSFSGELPSE 423

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  511 vvcphkcrceanvvecsslkLTKIPeripqSTAELRLNNNEISILEATGMFkKLTHLKKINLSNNKVS-EIEDgaFEGAA 589
Cdd:PLN00113  424 --------------------FTKLP-----LVYFLDISNNNLQGRINSRKW-DMPSLQMLSLARNKFFgGLPD--SFGSK 475

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  590 SVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLL 669
Cdd:PLN00113  476 RLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLS 555


                  ..
gi 145559530  670 AN 671
Cdd:PLN00113  556 QN 557
LRR_8 pfam13855
Leucine rich repeat;
110-169 3.96e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.07  E-value: 3.96e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530   110 ELERLRLNRNQLHMLPELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQI 169
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 43-217 6.07e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 57.87  E-value: 6.07e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530   43 TTVDCHGTGLQAIPK-NIPRNTERLELNGNNITRIhkNDFAGLKQLRVLQLMENQIGAVERgaFDDMKELERLRLNRNQ- 120
Cdd:cd21340     5 THLYLNDKNITKIDNlSLCKNLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRi 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  121 -----LHMLPEL--LFQNNQALSR---LDLSENAIQAIprkafrgATDLKNLQLDKNQISCIEEgaFRALRGLEVLTLNN 190
Cdd:cd21340    81 svvegLENLTNLeeLHIENQRLPPgekLTFDPRSLAAL-------SNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASN 151

                         170       180
                  ....*....|....*....|....*....
gi 145559530  191 NNITTIP--VSSFNHMPKLRTFRLHSNHL 217
Cdd:cd21340   152 NQISDLEelLDLLSSWPSLRELDLTGNPV 180
LRR_8 pfam13855
Leucine rich repeat;
389-441 6.22e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.68  E-value: 6.22e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 145559530   389 NANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPF 441
Cdd:pfam13855    9 SNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 55-217 1.06e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 60.25  E-value: 1.06e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530   55 IPKNIP--RNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQI-GAVERGAFDdMKELERLRLNRNQ-LHMLPELLFQ 130
Cdd:PLN00113  396 IPKSLGacRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLqGRINSRKWD-MPSLQMLSLARNKfFGGLPDSFGS 474

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  131 NNqaLSRLDLSENAIQ-AIPRKaFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNIT-TIPvSSFNHMPKLR 208
Cdd:PLN00113  475 KR--LENLDLSRNQFSgAVPRK-LGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSgQIP-ASFSEMPVLS 550


                  ....*....
gi 145559530  209 TFRLHSNHL 217
Cdd:PLN00113  551 QLDLSQNQL 559
LRR_8 pfam13855
Leucine rich repeat;
786-832 5.25e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.99  E-value: 5.25e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 145559530   786 LQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLR 832
Cdd:pfam13855    3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLP 49
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 43-194 6.37e-08

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 56.72  E-value: 6.37e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530   43 TTVDCHGT-----GLQAIPKNI--PRNTERLELNGNNIT-----RIHKNdFAGLKQLRVLQLMENQIGavERGA------ 104
Cdd:COG5238   239 TTLDLSNNqigdeGVIALAEALknNTTVETLYLSGNQIGaegaiALAKA-LQGNTTLTSLDLSVNRIG--DEGAialaeg 315

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  105 FDDMKELERLRLNRNQL-----HMLPELLfQNNQALSRLDLSENAIQAIPRKAF----RGATDLKNLQLDKNQISciEEG 175
Cdd:COG5238   316 LQGNKTLHTLNLAYNGIgaqgaIALAKAL-QENTTLHSLDLSDNQIGDEGAIALakylEGNTTLRELNLGKNNIG--KQG 392

                         170       180
                  ....*....|....*....|....
gi 145559530  176 AFRALRGLEV-----LTLNNNNIT 194
Cdd:COG5238   393 AEALIDALQTnrlhtLILDGNLIG 416
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 188-328 7.03e-08

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 57.78  E-value: 7.03e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530   188 LNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQ------RPTIglfTQCSGPASLRGLNVAEVQKSEF 261
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEkgvkvrQPEA---ALCAGPGALAGQPLLGIPLLDS 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530   262 SC-----------SGQGEAGRVPTCTLSSG--------SCPAMC-TCSNGIVDCRGKGLTAIPANLPETMTEIRLELNGI 321
Cdd:TIGR00864   79 GCdeeyvaclkdnSSGGGAARSELVIFSAAheglfqpeACNAFCfSAGHGLAALGEQGECLCGAAQPSEANFACESLCSG 158


                   ....*..
gi 145559530   322 KSIPPGA 328
Cdd:TIGR00864  159 PPPPPAA 165
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
28-197 1.19e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 56.63  E-value: 1.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530   28 RLGASACPALCTCTGTTVDCHGTGLQAIPKNIPRNTERLELNGNNITRI-------------HKNDFAGLKQ-----LRV 89
Cdd:PRK15370  187 ILGLTTIPACIPEQITTLILDNNELKSLPENLQGNIKTLYANSNQLTSIpatlpdtiqemelSINRITELPErlpsaLQS 266

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530   90 LQLMENQIGAVERGAFDdmkELERLRLNRNQLHMLPELLfqnNQALSRLDLSENAIQAIPRKAFRGatdLKNLQLDKNQI 169
Cdd:PRK15370  267 LDLFHNKISCLPENLPE---ELRYLSVYDNSIRTLPAHL---PSGITHLNVQSNSLTALPETLPPG---LKTLEAGENAL 337

                         170       180
                  ....*....|....*....|....*...
gi 145559530  170 SCIEEGAFRALRgleVLTLNNNNITTIP 197
Cdd:PRK15370  338 TSLPASLPPELQ---VLDVSKNQITVLP 362
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 545-701 4.50e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 52.48  E-value: 4.50e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  545 LRLNNNEISILEATGMFKKLTHLKkinLSNNKVSEIEDgaFEGAASVSELHLTANQLESIRsgMFRGLDGLRTLMLRNNR 624
Cdd:cd21340     7 LYLNDKNITKIDNLSLCKNLKVLY---LYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIE--NLENLVNLKKLYLGGNR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  625 ISCIHN---------------------------DSFTGLRN-VRLLSLYDNQITTVSPgaFDTLQSLSTLNLLANPFNCN 676
Cdd:cd21340    80 ISVVEGlenltnleelhienqrlppgekltfdpRSLAALSNsLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDL 157

                         170       180
                  ....*....|....*....|....*..
gi 145559530  677 CQLAW-LGGWLRKRKI-VTGNPRCQNP 701
Cdd:cd21340   158 EELLDlLSSWPSLRELdLTGNPVCKKP 184
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
749-868 4.71e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 54.70  E-value: 4.71e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  749 NKHLRALPKGIPKNVTELYLDGNQFTLVPGQLStfKYLQLVDLSNNKISSLSNSSftnMSQLTTLILSYNALQCIP---P 825
Cdd:PRK15370  208 NNELKSLPENLQGNIKTLYANSNQLTSIPATLP--DTIQEMELSINRITELPERL---PSALQSLDLFHNKISCLPenlP 282

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 145559530  826 LAFQglrslrLLSLHGNDISTLQEGIfadVTSLSHLAIGANPL 868
Cdd:PRK15370  283 EELR------YLSVYDNSIRTLPAHL---PSGITHLNVQSNSL 316
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 61-439 8.34e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 54.08  E-value: 8.34e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530   61 RNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLH-MLPELLFqNNQALSRLD 139
Cdd:PLN00113  212 KSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIF-SLQKLISLD 290

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  140 LSENAIQA-IPRKAFRgatdlknlqldknqiscieegafraLRGLEVLTLNNNNIT-TIPVSsFNHMPKLRTFRLHSNHL 217
Cdd:PLN00113  291 LSDNSLSGeIPELVIQ-------------------------LQNLEILHLFSNNFTgKIPVA-LTSLPRLQVLQLWSNKF 344

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  218 fcdchlawlsqwlrqrptiglftqcSG--PASLRGLNVAEVqkseFSCSGQGEAGRVPTCTLSSGSCPAMCTCSNGIVDC 295
Cdd:PLN00113  345 -------------------------SGeiPKNLGKHNNLTV----LDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGE 395

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  296 RGKGLTAIpanlpETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNN----------------QIAEIA--------PD 351
Cdd:PLN00113  396 IPKSLGAC-----RSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNnlqgrinsrkwdmpslQMLSLArnkffgglPD 470

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  352 AFqGLRSLNSLVLYGNKITD-LPRGvFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRA 430
Cdd:PLN00113  471 SF-GSKRLENLDLSRNQFSGaVPRK-LGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPV 548


                  ....*....
gi 145559530  431 IQTLHLAQN 439
Cdd:PLN00113  549 LSQLDLSQN 557
LRR_8 pfam13855
Leucine rich repeat;
86-145 1.40e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.75  E-value: 1.40e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530    86 QLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLHMLPELLFQNNQALSRLDLSENAI 145
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1085-1119 1.48e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.09  E-value: 1.48e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 145559530 1085 DDCRD-HRCQNGAQCMDEVNSYSCLCAEGYSGQLCE 1119
Cdd:cd00054     3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 87-220 5.40e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 50.05  E-value: 5.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530   87 LRVLQLMENQIGA-----VERGAFDDMKELERLRLNRNQL-HMLPE---LLFQNNQALSRLDLSENAI--QAIPR--KAF 153
Cdd:cd00116   110 LQELKLNNNGLGDrglrlLAKGLKDLPPALEKLVLGRNRLeGASCEalaKALRANRDLKELNLANNGIgdAGIRAlaEGL 189

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 145559530  154 RGATDLKNLQLDKNQISCIE----EGAFRALRGLEVLTLNNNNITTIPVSSF-----NHMPKLRTFRLHSNHLFCD 220
Cdd:cd00116   190 KANCNLEVLDLNNNGLTDEGasalAETLASLKSLEVLNLGDNNLTDAGAAALasallSPNISLLTLSLSCNDITDD 265
LRRCT smart00082
Leucine rich repeat C-terminal domain;
866-915 5.59e-06

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 44.73  E-value: 5.59e-06
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 145559530    866 NPLYCDCHLRWLSSWV--KTGYKEPGIARCAGPQDMEGKLLLTTPAkKFECQ 915
Cdd:smart00082    1 NPFICDCELRWLLRWLqaNEHLQDPVDLRCASPSSLRGPLLELLHS-EFKCP 51
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1005-1041 6.12e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 6.12e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 145559530 1005 NTDDCVD-HACANGGVCVDGVGNYTCQCPLQYEGKACE 1041
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
299-420 6.51e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 50.85  E-value: 6.51e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  299 GLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRslnslvLYGNKITDLPRGVfg 378
Cdd:PRK15370  189 GLTTIPACIPEQITTLILDNNELKSLPENLQGNIKTLYANSNQLTSIPATLPDTIQEME------LSINRITELPERL-- 260

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 145559530  379 gLYTLQLLLLNANKINCIrPDAFQDlqNLSLLSLYDNKIQSL 420
Cdd:PRK15370  261 -PSALQSLDLFHNKISCL-PENLPE--ELRYLSVYDNSIRTL 298
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 561-823 9.83e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 48.24  E-value: 9.83e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  561 FKKLTHLkkiNLSNNKVSEIEDgaFEGAASVSELHLTANQLESIRsgmfrGLDGLR---TLMLRNNRISCIHNdsFTGLR 637
Cdd:cd21340     1 LKRITHL---YLNDKNITKIDN--LSLCKNLKVLYLYDNKITKIE-----NLEFLTnltHLYLQNNQIEKIEN--LENLV 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  638 NVRLLSLYDNQITTVSpgAFDTLQSLSTLNLlanpfncncqlawlggwlrkrkivtgnprcqnpdflrqiplqdvafpdf 717
Cdd:cd21340    69 NLKKLYLGGNRISVVE--GLENLTNLEELHI------------------------------------------------- 97

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  718 rceEGQeeggCLPRPQC-PQECACLDTVVRCsnkhlralpkgipknvtelyldgnqftlvpgqlstfkyLQLVDLSNNKI 796
Cdd:cd21340    98 ---ENQ----RLPPGEKlTFDPRSLAALSNS--------------------------------------LRVLNISGNNI 132

                         250       260
                  ....*....|....*....|....*..
gi 145559530  797 SSLsnSSFTNMSQLTTLILSYNALQCI 823
Cdd:cd21340   133 DSL--EPLAPLRNLEQLDASNNQISDL 157
LRRNT smart00013
Leucine rich repeat N-terminal domain;
33-64 1.22e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 43.46  E-value: 1.22e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 145559530     33 ACPALCTCTGTTVDCHGTGLQAIPKNIPRNTE 64
Cdd:smart00013    1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1044-1080 1.51e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 1.51e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 145559530 1044 VDLCSPDlNPCQHEAQCVGTPDGPRCECMPGYAGDNC 1080
Cdd:cd00054     2 IDECASG-NPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
LRR_8 pfam13855
Leucine rich repeat;
181-217 1.96e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.67  E-value: 1.96e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 145559530   181 RGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHL 217
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL 37
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 412-475 2.23e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 49.31  E-value: 2.23e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 145559530   412 LYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICDCNLKWLADFLRTNPIET---SGARCASPRRLANK 475
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrqpEAALCAGPGALAGQ 68
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 50-195 2.37e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 48.63  E-value: 2.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530   50 TGLQAIPKNIPRNTE--RLELNGNNITRIHKNDFA----GLKQLRVLQLMENQIGavERGafddmkelerlrlnrnqLHM 123
Cdd:COG5238   195 EGIEELAEALTQNTTvtTLWLKRNPIGDEGAEILAealkGNKSLTTLDLSNNQIG--DEG-----------------VIA 255

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  124 LPELLfQNNQALSRLDLSENAIQA----IPRKAFRGATDLKNLQLDKNQISciEEGAF---RALRG---LEVLTLNNNNI 193
Cdd:COG5238   256 LAEAL-KNNTTVETLYLSGNQIGAegaiALAKALQGNTTLTSLDLSVNRIG--DEGAIalaEGLQGnktLHTLNLAYNGI 332


                  ..
gi 145559530  194 TT 195
Cdd:COG5238   333 GA 334
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
296-373 2.49e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 48.92  E-value: 2.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  296 RGKGLTAIPANLPETMTEIRLELNGIKSIP---PGAfspyrkLRRIDLSNNQIAEIAPDAFQGLRSLNslvLYGNKITDL 372
Cdd:PRK15370  228 NSNQLTSIPATLPDTIQEMELSINRITELPerlPSA------LQSLDLFHNKISCLPENLPEELRYLS---VYDNSIRTL 298


                  .
gi 145559530  373 P 373
Cdd:PRK15370  299 P 299
LRRCT smart00082
Leucine rich repeat C-terminal domain;
671-719 4.71e-05

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 42.42  E-value: 4.71e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|.
gi 145559530    671 NPFNCNCQLAWLGGWLRKRKIV--TGNPRCQNPDFLRQiPLQDVAFPDFRC 719
Cdd:smart00082    1 NPFICDCELRWLLRWLQANEHLqdPVDLRCASPSSLRG-PLLELLHSEFKC 50
LRRNT smart00013
Leucine rich repeat N-terminal domain;
282-313 5.20e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 41.53  E-value: 5.20e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 145559530    282 CPAMCTCSNGIVDCRGKGLTAIPANLPETMTE 313
Cdd:smart00013    2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 282-308 5.23e-05

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 41.46  E-value: 5.23e-05
                           10        20
                   ....*....|....*....|....*..
gi 145559530   282 CPAMCTCSNGIVDCRGKGLTAIPANLP 308
Cdd:pfam01462    2 CPVPCHCSATVVNCSDRGLTAVPRDLP 28
EGF_CA smart00179
Calcium-binding EGF-like domain;
1085-1119 5.94e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.46  E-value: 5.94e-05
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 145559530   1085 DDC-RDHRCQNGAQCMDEVNSYSCLCAEGYS-GQLCE 1119
Cdd:smart00179    3 DECaSGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 548-673 8.54e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.54  E-value: 8.54e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  548 NNNEISILEATG---------MFKKLTHLKKINLSNNKVS-EIEDGAFEGAASVSELHLTANQLE-SIRSGMfrgLDGLR 616
Cdd:PLN00113   67 NSSRVVSIDLSGknisgkissAIFRLPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFTgSIPRGS---IPNLE 143

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  617 TLMLRNNRISC-IHND--SFTglrNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPF 673
Cdd:PLN00113  144 TLDLSNNMLSGeIPNDigSFS---SLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQL 200
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 114-374 8.55e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.55  E-value: 8.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  114 LRLNRNQLHMLPEL-LFQNnqaLSRLDLSENAIQAIPrkAFRGATDLKNLQLDKNQISCIEEgaFRALRGLEVLTLNNNN 192
Cdd:cd21340     7 LYLNDKNITKIDNLsLCKN---LKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  193 ITTipVSSFNHMPKLRTfrLHsnhlfcdchlawLSqwlRQRPTIGlFTQCSGPASLRGLnvaevqksefSCSGQgeagrv 272
Cdd:cd21340    80 ISV--VEGLENLTNLEE--LH------------IE---NQRLPPG-EKLTFDPRSLAAL----------SNSLR------ 123

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  273 ptctlssgscpamctcsngIVDCRGkgltaipanlpetmteirlelNGIKSIPPgaFSPYRKLRRIDLSNNQIAEIAP-- 350
Cdd:cd21340   124 -------------------VLNISG---------------------NNIDSLEP--LAPLRNLEQLDASNNQISDLEEll 161

                         250       260
                  ....*....|....*....|....
gi 145559530  351 DAFQGLRSLNSLVLYGNKITDLPR 374
Cdd:cd21340   162 DLLSSWPSLRELDLTGNPVCKKPK 185
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 33-60 1.25e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 40.30  E-value: 1.25e-04
                           10        20
                   ....*....|....*....|....*...
gi 145559530    33 ACPALCTCTGTTVDCHGTGLQAIPKNIP 60
Cdd:pfam01462    1 ACPVPCHCSATVVNCSDRGLTAVPRDLP 28
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1087-1115 1.62e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.06  E-value: 1.62e-04
                           10        20
                   ....*....|....*....|....*....
gi 145559530  1087 CRDHRCQNGAQCMDEVNSYSCLCAEGYSG 1115
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
LRRNT smart00013
Leucine rich repeat N-terminal domain;
733-765 1.66e-04

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 40.38  E-value: 1.66e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 145559530    733 QCPQECACLDTVVRCSNKHLRALPKGIPKNVTE 765
Cdd:smart00013    1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 927-962 1.69e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 1.69e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 145559530  927 DLCLS-SPCQNQGTCHNDPlEVYRCACPSGYKGRDCE 962
Cdd:cd00054     3 DECASgNPCQNGGTCVNTV-GSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
1005-1041 1.73e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 1.73e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 145559530   1005 NTDDCV-DHACANGGVCVDGVGNYTCQCPLQYE-GKACE 1041
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 183-220 2.33e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.92  E-value: 2.33e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 145559530   183 LEVLTLNNNNITTIPvsSFNHMPKLRTFRLHSNHLFCD 220
Cdd:pfam12799    3 LEVLDLSNNQITDIP--PLAKLPNLETLDLSGNNKITD 38
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 334-373 3.04e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.92  E-value: 3.04e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 145559530   334 KLRRIDLSNNQIAEIapDAFQGLRSLNSLVLYGN-KITDLP 373
Cdd:pfam12799    2 NLEVLDLSNNQITDI--PPLAKLPNLETLDLSGNnKITDLS 40
LRRCT smart00082
Leucine rich repeat C-terminal domain;
439-469 3.30e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 39.72  E-value: 3.30e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 145559530    439 NPFICDCNLKWLADFLRTNPI--ETSGARCASP 469
Cdd:smart00082    1 NPFICDCELRWLLRWLQANEHlqDPVDLRCASP 33
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 561-657 4.73e-04

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 41.76  E-value: 4.73e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530   561 FKKLTHLKKINLSNNkVSEIEDGAFEGaASVSELHLTANqLESIRSGMFRGLDGLRTLMLRNNrISCIHNDSF--TGLRN 638
Cdd:pfam13306   30 FSNCTSLKSITLPSS-LTSIGSYAFYN-CSLTSITIPSS-LTSIGEYAFSNCSNLKSITLPSN-LTSIGSYAFsnCSLKS 105

                           90
                   ....*....|....*....
gi 145559530   639 VRLLSlydnQITTVSPGAF 657
Cdd:pfam13306  106 ITIPS----SVTTIGSYAF 120
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 966-1002 4.89e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.16  E-value: 4.89e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 145559530  966 DSCSSG-PCENGGTCHAQEGEdapFTCSCPTGFEGPTC 1002
Cdd:cd00054     3 DECASGnPCQNGGTCVNTVGS---YRCSCPPGYTGRNC 37
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 544-627 5.50e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.88  E-value: 5.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  544 ELRLNNNEI------SILEAtgmFKKLTHLKKINLSNNKVSEIEDGAFEGA----ASVSELHLTANQLES-----IRSGM 608
Cdd:cd00116   169 ELNLANNGIgdagirALAEG---LKANCNLEVLDLNNNGLTDEGASALAETlaslKSLEVLNLGDNNLTDagaaaLASAL 245

                          90
                  ....*....|....*....
gi 145559530  609 FRGLDGLRTLMLRNNRISC 627
Cdd:cd00116   246 LSPNISLLTLSLSCNDITD 264
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 544-582 7.01e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 38.77  E-value: 7.01e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 145559530   544 ELRLNNNEISILEAtgmFKKLTHLKKINLS-NNKVSEIED 582
Cdd:pfam12799    5 VLDLSNNQITDIPP---LAKLPNLETLDLSgNNKITDLSD 41
EGF_CA smart00179
Calcium-binding EGF-like domain;
1044-1080 7.08e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 7.08e-04
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 145559530   1044 VDLCSPDlNPCQHEAQCVGTPDGPRCECMPGY-AGDNC 1080
Cdd:smart00179    2 IDECASG-NPCQNGGTCVNTVGSYRCECPPGYtDGRNC 38
LRRCT smart00082
Leucine rich repeat C-terminal domain;
219-264 8.75e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 38.57  E-value: 8.75e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*...
gi 145559530    219 CDCHLAWLSQWLRQRPTIGLF--TQCSGPASLRGLnVAEVQKSEFSCS 264
Cdd:smart00082    5 CDCELRWLLRWLQANEHLQDPvdLRCASPSSLRGP-LLELLHSEFKCP 51
LRRNT smart00013
Leucine rich repeat N-terminal domain;
513-542 1.33e-03

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 37.68  E-value: 1.33e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 145559530    513 CPHKCRCEANVVECSSLKLTKIPERIPQST 542
Cdd:smart00013    2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDT 31
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 733-760 1.70e-03

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 37.22  E-value: 1.70e-03
                           10        20
                   ....*....|....*....|....*...
gi 145559530   733 QCPQECACLDTVVRCSNKHLRALPKGIP 760
Cdd:pfam01462    1 ACPVPCHCSATVVNCSDRGLTAVPRDLP 28
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 66-150 2.02e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 41.31  E-value: 2.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530   66 LELNGNNITRIhkNDFAGLKQLRVLQLMENQIgavergafDDMKELERlrlnrnqlhmlpelLFQNNQALSRLDLSENAI 145
Cdd:cd21340   125 LNISGNNIDSL--EPLAPLRNLEQLDASNNQI--------SDLEELLD--------------LLSSWPSLRELDLTGNPV 180


                  ....*
gi 145559530  146 QAIPR 150
Cdd:cd21340   181 CKKPK 185
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1009-1038 2.19e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.98  E-value: 2.19e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 145559530  1009 CVDHACANGGVCVDGVGNYTCQCPLQYEGK 1038
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 567-671 2.47e-03

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 39.45  E-value: 2.47e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530   567 LKKINLSNNkVSEIEDGAFEGAASVSELHLTaNQLESIRSGMFRGLdGLRTLMLRNNrISCIHNDSFTGLRNVRLLSLYD 646
Cdd:pfam13306   13 LTSITIPSS-LTSIGEYAFSNCTSLKSITLP-SSLTSIGSYAFYNC-SLTSITIPSS-LTSIGEYAFSNCSNLKSITLPS 88

                           90       100
                   ....*....|....*....|....*.
gi 145559530   647 NqITTVSPGAF-DTlqSLSTLNLLAN 671
Cdd:pfam13306   89 N-LTSIGSYAFsNC--SLKSITIPSS 111
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 1052-1079 2.47e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 37.07  E-value: 2.47e-03
                          10        20
                  ....*....|....*....|....*...
gi 145559530 1052 NPCQHEAQCVGTPDGPRCECMPGYAGDN 1079
Cdd:cd00053     6 NPCSNGGTCVNTPGSYRCVCPPGYTGDR 33
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 743-861 2.83e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.92  E-value: 2.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  743 TVVRCSNKHLRALPK-GIPKNVTELYLDGNQFTLVPGqLSTFKYLQLVDLSNNKISSLSNssFTNMSQLTTLILSynalq 821
Cdd:cd21340     5 THLYLNDKNITKIDNlSLCKNLKVLYLYDNKITKIEN-LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLG----- 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 145559530  822 cipplafqglrslrllslhGNDISTLqEGiFADVTSLSHL 861
Cdd:cd21340    77 -------------------GNRISVV-EG-LENLTNLEEL 95
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 1090-1116 3.13e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 36.69  E-value: 3.13e-03
                          10        20
                  ....*....|....*....|....*..
gi 145559530 1090 HRCQNGAQCMDEVNSYSCLCAEGYSGQ 1116
Cdd:cd00053     6 NPCSNGGTCVNTPGSYRCVCPPGYTGD 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1136-1163 3.20e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 3.20e-03
                          10        20
                  ....*....|....*....|....*...
gi 145559530 1136 CQNGANCVDQGNRPVCQCLPGFGGPECE 1163
Cdd:cd00054    11 CQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 319-441 3.93e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.54  E-value: 3.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  319 NGIKSIPpgAFSPYRKLRRIDLSNNQIAEIAPdaFQGLRSLNSLVLYGNKIT-------------------DLPRGV--- 376
Cdd:cd21340    34 NKITKIE--NLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISvveglenltnleelhienqRLPPGEklt 109

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 145559530  377 FGGLYTLQLLLL----NA--NKINCIRPdaFQDLQNLSLLSLYDNKIQSLA--KGTFTSLRAIQTLHLAQNPF 441
Cdd:cd21340   110 FDPRSLAALSNSlrvlNIsgNNIDSLEP--LAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGNPV 180
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 929-960 4.71e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.21  E-value: 4.71e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 145559530   929 CLSSPCQNQGTCHNDPlEVYRCACPSGYKGRD 960
Cdd:pfam00008    1 CAPNPCSNGGTCVDTP-GGYTCICPEGYTGKR 31
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 311-474 5.40e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.15  E-value: 5.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  311 MTEIRLELNGIKSIppGAFSPYRKLRRIDLSNNQIAEIapDAFQGLRSLNSLVLYGNKITdlprgvfgglytlqllllna 390
Cdd:cd21340     4 ITHLYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIE-------------------- 59

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530  391 nKIncirpDAFQDLQNLSLLSLYDNKIQSLaKGtFTSLRAIQTLHLA-QN-----PFICDCN-LKWLADFLRTnpIETSG 463
Cdd:cd21340    60 -KI-----ENLENLVNLKKLYLGGNRISVV-EG-LENLTNLEELHIEnQRlppgeKLTFDPRsLAALSNSLRV--LNISG 129

                         170
                  ....*....|.
gi 145559530  464 ARCASPRRLAN 474
Cdd:cd21340   130 NNIDSLEPLAP 140
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 1092-1113 5.48e-03

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 35.77  E-value: 5.48e-03
                           10        20
                   ....*....|....*....|..
gi 145559530  1092 CQNGAQCMDEVNSYSCLCAEGY 1113
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPPGY 22
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 615-654 6.37e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.07  E-value: 6.37e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 145559530   615 LRTLMLRNNRISCIhnDSFTGLRNVRLLSLYDN-QITTVSP 654
Cdd:pfam12799    3 LEVLDLSNNQITDI--PPLAKLPNLETLDLSGNnKITDLSD 41
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 968-1001 6.64e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.82  E-value: 6.64e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 145559530   968 CSSGPCENGGTCHAQEGEdapFTCSCPTGFEGPT 1001
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGG---YTCICPEGYTGKR 31
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 930-962 6.82e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 35.92  E-value: 6.82e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 145559530  930 LSSPCQNQGTCHNDPlEVYRCACPSGYKG-RDCE 962
Cdd:cd00053     4 ASNPCSNGGTCVNTP-GSYRCVCPPGYTGdRSCE 36
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 513-539 6.88e-03

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 35.68  E-value: 6.88e-03
                           10        20
                   ....*....|....*....|....*..
gi 145559530   513 CPHKCRCEANVVECSSLKLTKIPERIP 539
Cdd:pfam01462    2 CPVPCHCSATVVNCSDRGLTAVPRDLP 28
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1050-1079 7.05e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.44  E-value: 7.05e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 145559530  1050 DLNPCQHEAQCVGTPDGPRCECMPGYAGDN 1079
Cdd:pfam00008    2 APNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
PLN03150 PLN03150
hypothetical protein; Provisional
 776-820 7.05e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.95  E-value: 7.05e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 145559530  776 VPGQLSTFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNAL 820
Cdd:PLN03150  434 IPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSF 478
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 525-616 7.98e-03

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 37.91  E-value: 7.98e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145559530   525 ECSSLKLTKIPERIPQ---------STAELRLNNNEISILEatGMFKKLTHLKKINLSNNkVSEIEDGAFEGaASVSELH 595
Cdd:pfam13306   32 NCTSLKSITLPSSLTSigsyafyncSLTSITIPSSLTSIGE--YAFSNCSNLKSITLPSN-LTSIGSYAFSN-CSLKSIT 107

                           90       100
                   ....*....|....*....|.
gi 145559530   596 LTANqLESIRSGMFRGLDGLR 616
Cdd:pfam13306  108 IPSS-VTTIGSYAFSNCSNLK 127
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
180-203 8.87e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 35.02  E-value: 8.87e-03
                            10        20
                    ....*....|....*....|....
gi 145559530    180 LRGLEVLTLNNNNITTIPVSSFNH 203
Cdd:smart00369    1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR smart00370
Leucine-rich repeats, outliers;
180-203 8.87e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.02  E-value: 8.87e-03
                            10        20
                    ....*....|....*....|....
gi 145559530    180 LRGLEVLTLNNNNITTIPVSSFNH 203
Cdd:smart00370    1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_8 pfam13855
Leucine rich repeat;
405-439 8.89e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 8.89e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 145559530   405 QNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQN 439
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNN 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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