NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|341940371|sp|O54991|]
View 

RecName: Full=Contactin-associated protein 1; Short=Caspr; Short=Caspr1; AltName: Full=MHDNIV; AltName: Full=NCP1; AltName: Full=Neurexin IV; AltName: Full=Neurexin-4; AltName: Full=Paranodin; Flags: Precursor

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 37-168 4.13e-48

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


:

Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 168.30  E-value: 4.13e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940371   37 RSLGASSYYGLFTTARFARLHGISGWSPRIGDPNPWLQIDLMKKHRIRAVATQGAFN--SWDWVTRYMLLYGDRVDSWTP 114
Cdd:cd00057    12 DQITASSSYSSGWEASRARLNSDNAWTPAVNDPPQWLQVDLGKTRRVTGIQTQGRKGggSSEWVTSYKVQYSLDGETWTT 91

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 341940371  115 FYQKGHNATFFGNVNDSAVVRHDLHYHFTARYIRIVPLAWNprGKIGLRLGIYG 168
Cdd:cd00057    92 YKDKGEEKVFTGNSDGSTPVTNDFPPPIVARYIRILPTTWN--GNISLRLELYG 143
LamG smart00282
Laminin G domain;
200-332 2.53e-29

Laminin G domain;


:

Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 113.97  E-value: 2.53e-29
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940371    200 FAFSFKTEEKDGLLLHTEGSQG-DYVTLELQGAHLLLHMSLGSSPIQPRPGHTTVslggvlNDLSWHYVRVDRYGRDANF 278
Cdd:smart00282    2 ISFSFRTTSPNGLLLYAGSKGGgDYLALELRDGRLVLRYDLGSGPARLTSDPTPL------NDGQWHRVAVERNGRSVTL 75

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 341940371    279 TLDGYAH-HFVLNGDFERLNLENEIFIGGLV-GAARKNLAYRHNFRGCIENVIYNR 332
Cdd:smart00282   76 SVDGGNRvSGESPGGLTILNLDGPLYLGGLPeDLKLPPLPVTPGFRGCIRNLKVNG 131
LamG smart00282
Laminin G domain;
1084-1219 3.73e-27

Laminin G domain;


:

Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 107.81  E-value: 3.73e-27
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940371   1084 EVSFSFSTNSAPAVLLYVSSFVR-DYMAVLIkEDGTLQLRYQLGTSPYVYQLTTRPVTDGQPHSVNITRVYRNLFIQVDY 1162
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGgDYLALEL-RDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDG 79

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 341940371   1163 FPLTEQKfSLLVDSQLDSPKALYLGRVMETGVIDPEIqryNTPGFSGCLSGVRFNNV 1219
Cdd:smart00282   80 GNRVSGE-SPGGLTILNLDGPLYLGGLPEDLKLPPLP---VTPGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 363-514 7.23e-26

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 104.81  E-value: 7.23e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940371  363 PINFGGPHnFVQVPGFPR-RGRLAVSFRFRTWDLTGLLLFSHLGDGLGHVELMLSEGQVNVSIaQTGRKKLQFAAGYRLN 441
Cdd:cd00110     1 GVSFSGSS-YVRLPTLPApRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRY-DLGSGSLVLSSKTPLN 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 341940371  442 DGFWHEVNFVAQENHAVISIDD---VEGAEVRVSYPLLirTGTSYFFGGCPKPASRWGcHSNQTAFHGCMELLKVD 514
Cdd:cd00110    79 DGQWHSVSVERNGRSVTLSVDGervVESGSPGGSALLN--LDGPLYLGGLPEDLKSPG-LPVSPGFVGCIRDLKVN 151
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 788-938 1.73e-23

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 97.87  E-value: 1.73e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940371  788 TISFHTGAALRFPPIRAN-HSLDVSFYFRTSAPSGVFLENMGGPfcrwRRPYVRVELNTSRdVVFAFDigNGDENLTVHS 866
Cdd:cd00110     1 GVSFSGSSYVRLPTLPAPrTRLSISFSFRTTSPNGLLLYAGSQN----GGDFLALELEDGR-LVLRYD--LGSGSLVLSS 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940371  867 DDfEFNDDEWHLVRAEINVKQARLRVDHRPWVlRPMPLQTYIWLVYDQPLYVG--------SAELKRRPFVGCLRAMRLN 938
Cdd:cd00110    74 KT-PLNDGQWHSVSVERNGRSVTLSVDGERVV-ESGSPGGSALLNLDGPLYLGglpedlksPGLPVSPGFVGCIRDLKVN 151
GGGWT_bact super family cl49103
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 596-617 1.32e-05

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


The actual alignment was detected with superfamily member NF040941:

Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 43.32  E-value: 1.32e-05
                          10        20
                  ....*....|....*....|..
gi 341940371  596 SGNYTIDPDGSGPLKPFVVYCD 617
Cdd:NF040941   14 SGVYWIDPDGMGGLAPFQVYCD 35
4.1m smart00294
putative band 4.1 homologues' binding motif;
1305-1323 2.68e-05

putative band 4.1 homologues' binding motif;


:

Pssm-ID: 128590  Cd Length: 19  Bit Score: 42.13  E-value: 2.68e-05
                            10
                    ....*....|....*....
gi 341940371   1305 FYLQNHRYKGSYHTNEPKA 1323
Cdd:smart00294    1 MYRYKHRDEGSYHTHEPKG 19
FReD super family cl00085
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
 585-659 1.20e-03

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


The actual alignment was detected with superfamily member cd00087:

Pssm-ID: 412152 [Multi-domain]  Cd Length: 215  Bit Score: 41.84  E-value: 1.20e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 341940371  585 SC-EAYRLSGKYSGNYTIDPDGSgpLKPFVVYCDIR-ENRAWTVVRHdrlwttRVTGSsmdrpflgaiQYWNASWEE 659
Cdd:cd00087     5 DCsEVLQRGGRTSGVYTIQPPGS--NEPFQVYCDMDtDGGGWTVIQR------RGDGS----------VDFYRSWKE 63
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 545-574 1.61e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.36  E-value: 1.61e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 341940371   545 CSPNMCEHDGRCYQSWDDFICYCElTGYKG 574
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP-EGYTG 29
 
Name Accession Description Interval E-value
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 37-168 4.13e-48

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 168.30  E-value: 4.13e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940371   37 RSLGASSYYGLFTTARFARLHGISGWSPRIGDPNPWLQIDLMKKHRIRAVATQGAFN--SWDWVTRYMLLYGDRVDSWTP 114
Cdd:cd00057    12 DQITASSSYSSGWEASRARLNSDNAWTPAVNDPPQWLQVDLGKTRRVTGIQTQGRKGggSSEWVTSYKVQYSLDGETWTT 91

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 341940371  115 FYQKGHNATFFGNVNDSAVVRHDLHYHFTARYIRIVPLAWNprGKIGLRLGIYG 168
Cdd:cd00057    92 YKDKGEEKVFTGNSDGSTPVTNDFPPPIVARYIRILPTTWN--GNISLRLELYG 143
FA58C smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 25-169 3.56e-32

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 214572  Cd Length: 139  Bit Score: 122.62  E-value: 3.56e-32
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940371     25 GCNEELvGPLYARSLGASSYYglfTTARFARLHGIS--GWSPRIGDPNPWLQIDLMKKHRIRAVATQGAFNSWDWVTRYM 102
Cdd:smart00231    1 PCNEPL-GLESDSQITASSSY---WAAKIARLNGGSdgGWCPAKNDLPPWIQVDLGRLRTVTGVITGRRHGNGDWVTYKL 76

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 341940371    103 LLYGDRVDsWTPfYQKGHNATFFGNVNDSAVVRHDLHYHFTARYIRIVPLAWNprGKIGLRLGIYGC 169
Cdd:smart00231   77 EYSDDGVN-WTT-YKDGNSKVFPGNSDAGTVVLNDFPPPIVARYVRILPTGWN--GNIILRVELLGC 139
LamG smart00282
Laminin G domain;
200-332 2.53e-29

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 113.97  E-value: 2.53e-29
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940371    200 FAFSFKTEEKDGLLLHTEGSQG-DYVTLELQGAHLLLHMSLGSSPIQPRPGHTTVslggvlNDLSWHYVRVDRYGRDANF 278
Cdd:smart00282    2 ISFSFRTTSPNGLLLYAGSKGGgDYLALELRDGRLVLRYDLGSGPARLTSDPTPL------NDGQWHRVAVERNGRSVTL 75

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 341940371    279 TLDGYAH-HFVLNGDFERLNLENEIFIGGLV-GAARKNLAYRHNFRGCIENVIYNR 332
Cdd:smart00282   76 SVDGGNRvSGESPGGLTILNLDGPLYLGGLPeDLKLPPLPVTPGFRGCIRNLKVNG 131
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 204-333 3.00e-29

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 113.67  E-value: 3.00e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940371   204 FKTEEKDGLLLHTEGSQGDYVTLELQGAHLLLHMSLGSSPIqprpghTTVSLGGVLNDLSWHYVRVDRYGRDANFTLDGY 283
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYDLGSGPE------SLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQ 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 341940371   284 AHHFVLN-GDFERLNLENEIFIGGLVGAAR-KNLAYRHNFRGCIENVIYNRI 333
Cdd:pfam02210   75 TVVSSLPpGESLLLNLNGPLYLGGLPPLLLlPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 176-331 4.23e-29

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 114.05  E-value: 4.23e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940371  176 LYFDGDDAISYRFQRGASQSLwdVFAFSFKTEEKDGLLLHTEG-SQGDYVTLELQGAHLLLHMSLGSspiqprpGHTTVS 254
Cdd:cd00110     2 VSFSGSSYVRLPTLPAPRTRL--SISFSFRTTSPNGLLLYAGSqNGGDFLALELEDGRLVLRYDLGS-------GSLVLS 72

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 341940371  255 LGGVLNDLSWHYVRVDRYGRDANFTLDGYAH-HFVLNGDFERLNLENEIFIGGLVGAARKN-LAYRHNFRGCIENVIYN 331
Cdd:cd00110    73 SKTPLNDGQWHSVSVERNGRSVTLSVDGERVvESGSPGGSALLNLDGPLYLGGLPEDLKSPgLPVSPGFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
1084-1219 3.73e-27

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 107.81  E-value: 3.73e-27
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940371   1084 EVSFSFSTNSAPAVLLYVSSFVR-DYMAVLIkEDGTLQLRYQLGTSPYVYQLTTRPVTDGQPHSVNITRVYRNLFIQVDY 1162
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGgDYLALEL-RDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDG 79

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 341940371   1163 FPLTEQKfSLLVDSQLDSPKALYLGRVMETGVIDPEIqryNTPGFSGCLSGVRFNNV 1219
Cdd:smart00282   80 GNRVSGE-SPGGLTILNLDGPLYLGGLPEDLKLPPLP---VTPGFRGCIRNLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1089-1219 3.90e-27

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 107.51  E-value: 3.90e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940371  1089 FSTNSAPAVLLYVSSFVRDYMAVLIkEDGTLQLRYQLGTSPYVYQLTTRPVTDGQPHSVNITRVYRNLFIQVDYFPLTEQ 1168
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALEL-VNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSS 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 341940371  1169 KFSLLVDsQLDSPKALYLGRVMETgviDPEIQRYNTPGFSGCLSGVRFNNV 1219
Cdd:pfam02210   80 LPPGESL-LLNLNGPLYLGGLPPL---LLLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 363-514 7.23e-26

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 104.81  E-value: 7.23e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940371  363 PINFGGPHnFVQVPGFPR-RGRLAVSFRFRTWDLTGLLLFSHLGDGLGHVELMLSEGQVNVSIaQTGRKKLQFAAGYRLN 441
Cdd:cd00110     1 GVSFSGSS-YVRLPTLPApRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRY-DLGSGSLVLSSKTPLN 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 341940371  442 DGFWHEVNFVAQENHAVISIDD---VEGAEVRVSYPLLirTGTSYFFGGCPKPASRWGcHSNQTAFHGCMELLKVD 514
Cdd:cd00110    79 DGQWHSVSVERNGRSVTLSVDGervVESGSPGGSALLN--LDGPLYLGGLPEDLKSPG-LPVSPGFVGCIRDLKVN 151
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1073-1217 1.08e-25

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 104.42  E-value: 1.08e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940371 1073 YRGPVYNVTGEEVSFSFSTNSAPAVLLYVSSFVR-DYMAVLIkEDGTLQLRYQLGTSPYVYQlTTRPVTDGQPHSVNITR 1151
Cdd:cd00110    12 LPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGgDFLALEL-EDGRLVLRYDLGSGSLVLS-SKTPLNDGQWHSVSVER 89

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 341940371 1152 VYRNLFIQVDYFPLTEQKFSLLvDSQLDSPKALYLGRVMETGVIDPEIqryNTPGFSGCLSGVRFN 1217
Cdd:cd00110    90 NGRSVTLSVDGERVVESGSPGG-SALLNLDGPLYLGGLPEDLKSPGLP---VSPGFVGCIRDLKVN 151
F5_F8_type_C pfam00754
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
 41-166 1.34e-24

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.


Pssm-ID: 459925 [Multi-domain]  Cd Length: 127  Bit Score: 100.21  E-value: 1.34e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940371    41 ASSYYGLFTTARfARLHGI--SGWSPRIGDPNPWLQIDLMKKHRIRAVATQGAFNSWD-WVTRYMLLYGDRVDSWTPFYq 117
Cdd:pfam00754    4 ASSSYSGEGPAA-AALDGDpnTAWSAWSGDDPQWIQVDLGKPKKITGVVTQGRQDGSNgYVTSYKIEYSLDGENWTTVK- 81

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 341940371   118 kghNATFFGNVNDSAVVRHDLHYHFTARYIRIVPLAWNPRGKIGLRLGI 166
Cdd:pfam00754   82 ---DEKIPGNNDNNTPVTNTFDPPIKARYVRIVPTSWNGGNGIALRAEL 127
LamG smart00282
Laminin G domain;
386-516 6.38e-24

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 98.57  E-value: 6.38e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940371    386 VSFRFRTWDLTGLLLFSHLGDGLGHVELMLSEGQVNVSIAQTGRKKLQFAAGYRLNDGFWHEVNFVAQENHAVISIDDve 465
Cdd:smart00282    2 ISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDG-- 79

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....
gi 341940371    466 GAEVRVSYPL---LIRTGTSYFFGGCPKPASRWGcHSNQTAFHGCMELLKVDGQ 516
Cdd:smart00282   80 GNRVSGESPGgltILNLDGPLYLGGLPEDLKLPP-LPVTPGFRGCIRNLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 390-516 8.72e-24

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 97.88  E-value: 8.72e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940371   390 FRTWDLTGLLLFSHlGDGLGHVELMLSEGQVNVSIAQTGRKKLQFAAGYRLNDGFWHEVNFVAQENHAVISIDDVEGAEV 469
Cdd:pfam02210    1 FRTRQPNGLLLYAG-GGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSS 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 341940371   470 RVS-YPLLIRTGTSYFFGGCPKPaSRWGCHSNQTAFHGCMELLKVDGQ 516
Cdd:pfam02210   80 LPPgESLLLNLNGPLYLGGLPPL-LLLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 788-938 1.73e-23

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 97.87  E-value: 1.73e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940371  788 TISFHTGAALRFPPIRAN-HSLDVSFYFRTSAPSGVFLENMGGPfcrwRRPYVRVELNTSRdVVFAFDigNGDENLTVHS 866
Cdd:cd00110     1 GVSFSGSSYVRLPTLPAPrTRLSISFSFRTTSPNGLLLYAGSQN----GGDFLALELEDGR-LVLRYD--LGSGSLVLSS 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940371  867 DDfEFNDDEWHLVRAEINVKQARLRVDHRPWVlRPMPLQTYIWLVYDQPLYVG--------SAELKRRPFVGCLRAMRLN 938
Cdd:cd00110    74 KT-PLNDGQWHSVSVERNGRSVTLSVDGERVV-ESGSPGGSALLNLDGPLYLGglpedlksPGLPVSPGFVGCIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 814-940 7.56e-22

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 92.48  E-value: 7.56e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940371   814 FRTSAPSGVFLENMGGpfcrwRRPYVRVELNTSRdVVFAFDIGNGDENLTVHSDdfEFNDDEWHLVRAEINVKQARLRVD 893
Cdd:pfam02210    1 FRTRQPNGLLLYAGGG-----GSDFLALELVNGR-LVLRYDLGSGPESLLSSGK--NLNDGQWHSVRVERNGNTLTLSVD 72

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 341940371   894 HRPWVLRPMPLQTYIWLVyDQPLYVG--------SAELKRRPFVGCLRAMRLNGV 940
Cdd:pfam02210   73 GQTVVSSLPPGESLLLNL-NGPLYLGglppllllPALPVRAGFVGCIRDVRVNGE 126
LamG smart00282
Laminin G domain;
809-940 1.09e-21

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 92.02  E-value: 1.09e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940371    809 DVSFYFRTSAPSGVFLENMGGPfcrwRRPYVRVELNTSRdVVFAFDIGNGDENLTvhSDDFEFNDDEWHLVRAEINVKQA 888
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKG----GGDYLALELRDGR-LVLRYDLGSGPARLT--SDPTPLNDGQWHRVAVERNGRSV 73

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940371    889 RLRVDHRPWVLRPMPLQTYIWLVyDQPLYVG--------SAELKRRPFVGCLRAMRLNGV 940
Cdd:smart00282   74 TLSVDGGNRVSGESPGGLTILNL-DGPLYLGglpedlklPPLPVTPGFRGCIRNLKVNGK 132
GGGWT_bact NF040941
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 596-617 1.32e-05

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 43.32  E-value: 1.32e-05
                          10        20
                  ....*....|....*....|..
gi 341940371  596 SGNYTIDPDGSGPLKPFVVYCD 617
Cdd:NF040941   14 SGVYWIDPDGMGGLAPFQVYCD 35
4.1m smart00294
putative band 4.1 homologues' binding motif;
1305-1323 2.68e-05

putative band 4.1 homologues' binding motif;


Pssm-ID: 128590  Cd Length: 19  Bit Score: 42.13  E-value: 2.68e-05
                            10
                    ....*....|....*....
gi 341940371   1305 FYLQNHRYKGSYHTNEPKA 1323
Cdd:smart00294    1 MYRYKHRDEGSYHTHEPKG 19
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
 585-659 1.20e-03

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 41.84  E-value: 1.20e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 341940371  585 SC-EAYRLSGKYSGNYTIDPDGSgpLKPFVVYCDIR-ENRAWTVVRHdrlwttRVTGSsmdrpflgaiQYWNASWEE 659
Cdd:cd00087     5 DCsEVLQRGGRTSGVYTIQPPGS--NEPFQVYCDMDtDGGGWTVIQR------RGDGS----------VDFYRSWKE 63
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 545-574 1.61e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.36  E-value: 1.61e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 341940371   545 CSPNMCEHDGRCYQSWDDFICYCElTGYKG 574
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP-EGYTG 29
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
582-626 5.70e-03

Fibrinogen beta and gamma chains, C-terminal globular domain;


Pssm-ID: 395095 [Multi-domain]  Cd Length: 221  Bit Score: 39.81  E-value: 5.70e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 341940371   582 YKESCEAYRLSGKYSGNYTIDPDGSGplKPFVVYCDIR-ENRAWTV 626
Cdd:pfam00147    2 GRDCSDVYNKGAKTSGLYTIRPDGAT--KPFEVYCDMEtDGGGWTV 45
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 543-577 6.62e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 6.62e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 341940371  543 DRC-SPNMCEHDGRCYQSWDDFICYCeLTGYKGVTC 577
Cdd:cd00054     3 DECaSGNPCQNGGTCVNTVGSYRCSC-PPGYTGRNC 37
 
Name Accession Description Interval E-value
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 37-168 4.13e-48

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 168.30  E-value: 4.13e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940371   37 RSLGASSYYGLFTTARFARLHGISGWSPRIGDPNPWLQIDLMKKHRIRAVATQGAFN--SWDWVTRYMLLYGDRVDSWTP 114
Cdd:cd00057    12 DQITASSSYSSGWEASRARLNSDNAWTPAVNDPPQWLQVDLGKTRRVTGIQTQGRKGggSSEWVTSYKVQYSLDGETWTT 91

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 341940371  115 FYQKGHNATFFGNVNDSAVVRHDLHYHFTARYIRIVPLAWNprGKIGLRLGIYG 168
Cdd:cd00057    92 YKDKGEEKVFTGNSDGSTPVTNDFPPPIVARYIRILPTTWN--GNISLRLELYG 143
FA58C smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 25-169 3.56e-32

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 214572  Cd Length: 139  Bit Score: 122.62  E-value: 3.56e-32
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940371     25 GCNEELvGPLYARSLGASSYYglfTTARFARLHGIS--GWSPRIGDPNPWLQIDLMKKHRIRAVATQGAFNSWDWVTRYM 102
Cdd:smart00231    1 PCNEPL-GLESDSQITASSSY---WAAKIARLNGGSdgGWCPAKNDLPPWIQVDLGRLRTVTGVITGRRHGNGDWVTYKL 76

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 341940371    103 LLYGDRVDsWTPfYQKGHNATFFGNVNDSAVVRHDLHYHFTARYIRIVPLAWNprGKIGLRLGIYGC 169
Cdd:smart00231   77 EYSDDGVN-WTT-YKDGNSKVFPGNSDAGTVVLNDFPPPIVARYVRILPTGWN--GNIILRVELLGC 139
LamG smart00282
Laminin G domain;
200-332 2.53e-29

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 113.97  E-value: 2.53e-29
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940371    200 FAFSFKTEEKDGLLLHTEGSQG-DYVTLELQGAHLLLHMSLGSSPIQPRPGHTTVslggvlNDLSWHYVRVDRYGRDANF 278
Cdd:smart00282    2 ISFSFRTTSPNGLLLYAGSKGGgDYLALELRDGRLVLRYDLGSGPARLTSDPTPL------NDGQWHRVAVERNGRSVTL 75

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 341940371    279 TLDGYAH-HFVLNGDFERLNLENEIFIGGLV-GAARKNLAYRHNFRGCIENVIYNR 332
Cdd:smart00282   76 SVDGGNRvSGESPGGLTILNLDGPLYLGGLPeDLKLPPLPVTPGFRGCIRNLKVNG 131
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 204-333 3.00e-29

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 113.67  E-value: 3.00e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940371   204 FKTEEKDGLLLHTEGSQGDYVTLELQGAHLLLHMSLGSSPIqprpghTTVSLGGVLNDLSWHYVRVDRYGRDANFTLDGY 283
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYDLGSGPE------SLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQ 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 341940371   284 AHHFVLN-GDFERLNLENEIFIGGLVGAAR-KNLAYRHNFRGCIENVIYNRI 333
Cdd:pfam02210   75 TVVSSLPpGESLLLNLNGPLYLGGLPPLLLlPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 176-331 4.23e-29

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 114.05  E-value: 4.23e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940371  176 LYFDGDDAISYRFQRGASQSLwdVFAFSFKTEEKDGLLLHTEG-SQGDYVTLELQGAHLLLHMSLGSspiqprpGHTTVS 254
Cdd:cd00110     2 VSFSGSSYVRLPTLPAPRTRL--SISFSFRTTSPNGLLLYAGSqNGGDFLALELEDGRLVLRYDLGS-------GSLVLS 72

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 341940371  255 LGGVLNDLSWHYVRVDRYGRDANFTLDGYAH-HFVLNGDFERLNLENEIFIGGLVGAARKN-LAYRHNFRGCIENVIYN 331
Cdd:cd00110    73 SKTPLNDGQWHSVSVERNGRSVTLSVDGERVvESGSPGGSALLNLDGPLYLGGLPEDLKSPgLPVSPGFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
1084-1219 3.73e-27

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 107.81  E-value: 3.73e-27
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940371   1084 EVSFSFSTNSAPAVLLYVSSFVR-DYMAVLIkEDGTLQLRYQLGTSPYVYQLTTRPVTDGQPHSVNITRVYRNLFIQVDY 1162
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGgDYLALEL-RDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDG 79

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 341940371   1163 FPLTEQKfSLLVDSQLDSPKALYLGRVMETGVIDPEIqryNTPGFSGCLSGVRFNNV 1219
Cdd:smart00282   80 GNRVSGE-SPGGLTILNLDGPLYLGGLPEDLKLPPLP---VTPGFRGCIRNLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1089-1219 3.90e-27

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 107.51  E-value: 3.90e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940371  1089 FSTNSAPAVLLYVSSFVRDYMAVLIkEDGTLQLRYQLGTSPYVYQLTTRPVTDGQPHSVNITRVYRNLFIQVDYFPLTEQ 1168
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALEL-VNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSS 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 341940371  1169 KFSLLVDsQLDSPKALYLGRVMETgviDPEIQRYNTPGFSGCLSGVRFNNV 1219
Cdd:pfam02210   80 LPPGESL-LLNLNGPLYLGGLPPL---LLLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 363-514 7.23e-26

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 104.81  E-value: 7.23e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940371  363 PINFGGPHnFVQVPGFPR-RGRLAVSFRFRTWDLTGLLLFSHLGDGLGHVELMLSEGQVNVSIaQTGRKKLQFAAGYRLN 441
Cdd:cd00110     1 GVSFSGSS-YVRLPTLPApRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRY-DLGSGSLVLSSKTPLN 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 341940371  442 DGFWHEVNFVAQENHAVISIDD---VEGAEVRVSYPLLirTGTSYFFGGCPKPASRWGcHSNQTAFHGCMELLKVD 514
Cdd:cd00110    79 DGQWHSVSVERNGRSVTLSVDGervVESGSPGGSALLN--LDGPLYLGGLPEDLKSPG-LPVSPGFVGCIRDLKVN 151
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1073-1217 1.08e-25

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 104.42  E-value: 1.08e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940371 1073 YRGPVYNVTGEEVSFSFSTNSAPAVLLYVSSFVR-DYMAVLIkEDGTLQLRYQLGTSPYVYQlTTRPVTDGQPHSVNITR 1151
Cdd:cd00110    12 LPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGgDFLALEL-EDGRLVLRYDLGSGSLVLS-SKTPLNDGQWHSVSVER 89

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 341940371 1152 VYRNLFIQVDYFPLTEQKFSLLvDSQLDSPKALYLGRVMETGVIDPEIqryNTPGFSGCLSGVRFN 1217
Cdd:cd00110    90 NGRSVTLSVDGERVVESGSPGG-SALLNLDGPLYLGGLPEDLKSPGLP---VSPGFVGCIRDLKVN 151
F5_F8_type_C pfam00754
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
 41-166 1.34e-24

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.


Pssm-ID: 459925 [Multi-domain]  Cd Length: 127  Bit Score: 100.21  E-value: 1.34e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940371    41 ASSYYGLFTTARfARLHGI--SGWSPRIGDPNPWLQIDLMKKHRIRAVATQGAFNSWD-WVTRYMLLYGDRVDSWTPFYq 117
Cdd:pfam00754    4 ASSSYSGEGPAA-AALDGDpnTAWSAWSGDDPQWIQVDLGKPKKITGVVTQGRQDGSNgYVTSYKIEYSLDGENWTTVK- 81

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 341940371   118 kghNATFFGNVNDSAVVRHDLHYHFTARYIRIVPLAWNPRGKIGLRLGI 166
Cdd:pfam00754   82 ---DEKIPGNNDNNTPVTNTFDPPIKARYVRIVPTSWNGGNGIALRAEL 127
LamG smart00282
Laminin G domain;
386-516 6.38e-24

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 98.57  E-value: 6.38e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940371    386 VSFRFRTWDLTGLLLFSHLGDGLGHVELMLSEGQVNVSIAQTGRKKLQFAAGYRLNDGFWHEVNFVAQENHAVISIDDve 465
Cdd:smart00282    2 ISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDG-- 79

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....
gi 341940371    466 GAEVRVSYPL---LIRTGTSYFFGGCPKPASRWGcHSNQTAFHGCMELLKVDGQ 516
Cdd:smart00282   80 GNRVSGESPGgltILNLDGPLYLGGLPEDLKLPP-LPVTPGFRGCIRNLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 390-516 8.72e-24

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 97.88  E-value: 8.72e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940371   390 FRTWDLTGLLLFSHlGDGLGHVELMLSEGQVNVSIAQTGRKKLQFAAGYRLNDGFWHEVNFVAQENHAVISIDDVEGAEV 469
Cdd:pfam02210    1 FRTRQPNGLLLYAG-GGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSS 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 341940371   470 RVS-YPLLIRTGTSYFFGGCPKPaSRWGCHSNQTAFHGCMELLKVDGQ 516
Cdd:pfam02210   80 LPPgESLLLNLNGPLYLGGLPPL-LLLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 788-938 1.73e-23

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 97.87  E-value: 1.73e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940371  788 TISFHTGAALRFPPIRAN-HSLDVSFYFRTSAPSGVFLENMGGPfcrwRRPYVRVELNTSRdVVFAFDigNGDENLTVHS 866
Cdd:cd00110     1 GVSFSGSSYVRLPTLPAPrTRLSISFSFRTTSPNGLLLYAGSQN----GGDFLALELEDGR-LVLRYD--LGSGSLVLSS 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940371  867 DDfEFNDDEWHLVRAEINVKQARLRVDHRPWVlRPMPLQTYIWLVYDQPLYVG--------SAELKRRPFVGCLRAMRLN 938
Cdd:cd00110    74 KT-PLNDGQWHSVSVERNGRSVTLSVDGERVV-ESGSPGGSALLNLDGPLYLGglpedlksPGLPVSPGFVGCIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 814-940 7.56e-22

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 92.48  E-value: 7.56e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940371   814 FRTSAPSGVFLENMGGpfcrwRRPYVRVELNTSRdVVFAFDIGNGDENLTVHSDdfEFNDDEWHLVRAEINVKQARLRVD 893
Cdd:pfam02210    1 FRTRQPNGLLLYAGGG-----GSDFLALELVNGR-LVLRYDLGSGPESLLSSGK--NLNDGQWHSVRVERNGNTLTLSVD 72

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 341940371   894 HRPWVLRPMPLQTYIWLVyDQPLYVG--------SAELKRRPFVGCLRAMRLNGV 940
Cdd:pfam02210   73 GQTVVSSLPPGESLLLNL-NGPLYLGglppllllPALPVRAGFVGCIRDVRVNGE 126
LamG smart00282
Laminin G domain;
809-940 1.09e-21

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 92.02  E-value: 1.09e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940371    809 DVSFYFRTSAPSGVFLENMGGPfcrwRRPYVRVELNTSRdVVFAFDIGNGDENLTvhSDDFEFNDDEWHLVRAEINVKQA 888
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKG----GGDYLALELRDGR-LVLRYDLGSGPARLT--SDPTPLNDGQWHRVAVERNGRSV 73

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940371    889 RLRVDHRPWVLRPMPLQTYIWLVyDQPLYVG--------SAELKRRPFVGCLRAMRLNGV 940
Cdd:smart00282   74 TLSVDGGNRVSGESPGGLTILNL-DGPLYLGglpedlklPPLPVTPGFRGCIRNLKVNGK 132
Laminin_G_1 pfam00054
Laminin G domain;
204-332 8.22e-17

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 78.13  E-value: 8.22e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940371   204 FKTEEKDGLLLHTEG-SQGDYVTLELQGAHLLLHMSLGSSPIqprpghtTVSLGGVLNDLSWHYVRVDRYGRDANFTLDG 282
Cdd:pfam00054    1 FRTTEPSGLLLYNGTqTERDFLALELRDGRLEVSYDLGSGAA-------VVRSGDKLNDGKWHSVELERNGRSGTLSVDG 73

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 341940371   283 YAHHF---VLNGDFErLNLENEIFIGGL--VGAARKNLAYRHNFRGCIENVIYNR 332
Cdd:pfam00054   74 EARPTgesPLGATTD-LDVDGPLYVGGLpsLGVKKRRLAISPSFDGCIRDVIVNG 127
Laminin_G_1 pfam00054
Laminin G domain;
390-519 1.06e-12

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 66.57  E-value: 1.06e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940371   390 FRTWDLTGLLLFSHLGDGLGHVELMLSEGQVNVSIaQTGRKKLQFAAGYRLNDGFWHEVNFVAQENHAVISIDDveGAEV 469
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTERDFLALELRDGRLEVSY-DLGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDG--EARP 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 341940371   470 RVSYPL----LIRTGTSYFFGGCPKPASRWGCHSNQTAFHGCMELLKVDGQLVN 519
Cdd:pfam00054   78 TGESPLgattDLDVDGPLYVGGLPSLGVKKRRLAISPSFDGCIRDVIVNGKPLD 131
Laminin_G_1 pfam00054
Laminin G domain;
814-943 1.32e-10

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 60.41  E-value: 1.32e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940371   814 FRTSAPSGVFLENMGGPFcrwrRPYVRVELNTSRdVVFAFDIGNGDEnLTVHSDdfEFNDDEWHLVRAEINVKQARLRVD 893
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTE----RDFLALELRDGR-LEVSYDLGSGAA-VVRSGD--KLNDGKWHSVELERNGRSGTLSVD 72

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 341940371   894 HRPWVLRPMPLQTYIWLVYDQPLYVGSA----ELKRR-----PFVGCLRAMRLNGVTLN 943
Cdd:pfam00054   73 GEARPTGESPLGATTDLDVDGPLYVGGLpslgVKKRRlaispSFDGCIRDVIVNGKPLD 131
Laminin_G_1 pfam00054
Laminin G domain;
1089-1219 2.01e-10

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 60.02  E-value: 2.01e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940371  1089 FSTNSAPAVLLYVSSFV-RDYMAVLIKeDGTLQLRYQLGTSPyVYQLTTRPVTDGQPHSVNITRVYRNLFIQVD--YFPL 1165
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTeRDFLALELR-DGRLEVSYDLGSGA-AVVRSGDKLNDGKWHSVELERNGRSGTLSVDgeARPT 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 341940371  1166 TEQKFSllVDSQLDSPKALYLGRvMETGVIDPEIQRyNTPGFSGCLSGVRFNNV 1219
Cdd:pfam00054   79 GESPLG--ATTDLDVDGPLYVGG-LPSLGVKKRRLA-ISPSFDGCIRDVIVNGK 128
GGGWT_bact NF040941
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 596-617 1.32e-05

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 43.32  E-value: 1.32e-05
                          10        20
                  ....*....|....*....|..
gi 341940371  596 SGNYTIDPDGSGPLKPFVVYCD 617
Cdd:NF040941   14 SGVYWIDPDGMGGLAPFQVYCD 35
4.1m smart00294
putative band 4.1 homologues' binding motif;
1305-1323 2.68e-05

putative band 4.1 homologues' binding motif;


Pssm-ID: 128590  Cd Length: 19  Bit Score: 42.13  E-value: 2.68e-05
                            10
                    ....*....|....*....
gi 341940371   1305 FYLQNHRYKGSYHTNEPKA 1323
Cdd:smart00294    1 MYRYKHRDEGSYHTHEPKG 19
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
 585-659 1.20e-03

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 41.84  E-value: 1.20e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 341940371  585 SC-EAYRLSGKYSGNYTIDPDGSgpLKPFVVYCDIR-ENRAWTVVRHdrlwttRVTGSsmdrpflgaiQYWNASWEE 659
Cdd:cd00087     5 DCsEVLQRGGRTSGVYTIQPPGS--NEPFQVYCDMDtDGGGWTVIQR------RGDGS----------VDFYRSWKE 63
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 545-574 1.61e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.36  E-value: 1.61e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 341940371   545 CSPNMCEHDGRCYQSWDDFICYCElTGYKG 574
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP-EGYTG 29
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
582-626 5.70e-03

Fibrinogen beta and gamma chains, C-terminal globular domain;


Pssm-ID: 395095 [Multi-domain]  Cd Length: 221  Bit Score: 39.81  E-value: 5.70e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 341940371   582 YKESCEAYRLSGKYSGNYTIDPDGSGplKPFVVYCDIR-ENRAWTV 626
Cdd:pfam00147    2 GRDCSDVYNKGAKTSGLYTIRPDGAT--KPFEVYCDMEtDGGGWTV 45
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 543-577 6.62e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 6.62e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 341940371  543 DRC-SPNMCEHDGRCYQSWDDFICYCeLTGYKGVTC 577
Cdd:cd00054     3 DECaSGNPCQNGGTCVNTVGSYRCSC-PPGYTGRNC 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH