|
Name |
Accession |
Description |
Interval |
E-value |
| leuS_bact |
TIGR00396 |
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases ... |
4-840 |
0e+00 |
|
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases belong to two families so broadly different that they are represented by separate models. This model includes both eubacterial and mitochondrial leucyl-tRNA synthetases. It generates higher scores for some valyl-tRNA synthetases than for any archaeal or eukaryotic cytosolic leucyl-tRNA synthetase. Note that the enzyme from Aquifex aeolicus is split into alpha and beta chains; neither chain is long enough to score above the trusted cutoff, but the alpha chain scores well above the noise cutoff. The beta chain must be found by a model and search designed for partial length matches. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273057 [Multi-domain] Cd Length: 842 Bit Score: 1323.60 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 4 YEFIKIEKKWQEFWDNNKTYKVEEDPSIPKekrLYILDMFPYPSANgLHVGHPEGYTATDIFGRYKLLNGFHVLHPIGFD 83
Cdd:TIGR00396 1 YNHIEIEEKWQQKWDENKTFKVTDDSSKPK---YYILSMFPYPSGA-LHMGHVRNYTITDVLSRYYRMKGYNVLHPIGWD 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 84 SFGLPAENYAIQTGTHPQKSTEENINKFKKQIKALGFAYDWDREIRTHEENYYKWTQWIFLQLYKKGLAYVKEMPVWYCP 163
Cdd:TIGR00396 77 AFGLPAENAAIKRGIHPAKWTYENIANMKKQLQALGFSYDWDREIATCDPEYYKWTQWIFLELFEKGLAYVKEADVNWCP 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 164 ELGTVLANEEIIqtSDGpKSERGSYSVEKKYLRQWVLKITKYAERLLDDLEELE-WPESVKEMQRNWIGKSTGVEIEFEI 242
Cdd:TIGR00396 157 NDGTVLANEQVD--SDG-RSWRGDTPVEKKELKQWFLKITAYAEELLNDLEELDhWPESVKEMQRNWIGKSEGVEITFKI 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 243 EGHSDKIKVFTTRPDTIFGITYLVIAPENKLIEKITKNNFKqnVLKYVKHEELKSDLNRTSLEKDKSGVFTGSYAFHPIT 322
Cdd:TIGR00396 234 ADHDEKITVFTTRPDTIFGVTYLALAPEHPLVEKAAENNPK--VAAFIKKILNKTVAERTKATKEKKGVDTGIKAIHPLT 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 323 NEKIPIWVGSYVLGTYGTGAVMGVPAHDERDFQFAKKYQLKILPVISKSGKNEILEKAFVDDGISINSpNEFNNLKNSEV 402
Cdd:TIGR00396 312 GEKIPIWVANYVLMEYGTGAVMGVPAHDERDFEFAQKYGLPIKPVIDPAEKDLSLTAAYTEDGVLVNS-GEFNGLNSSEA 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 403 KDKVIKWLTKNKKGKEKVAYKLRDWIFSRQRYWGEPIPILFDKLGNAIPLEENDLPLKLPEIANYKPSgtGESPLSRIKD 482
Cdd:TIGR00396 391 RNAIIDMLEKEGKGKRKVNYRLRDWGFSRQRYWGEPIPIIHCEDGGVVPVPEEDLPVILPEDVVYDGD--GGSPLSRIPE 468
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 483 WVNVKDMGFT----RETNTMPQWAGSCWYYLRYLDPKNSKEFANKKKIEYWMPVDLYIGGAEHTVLHLLYSRFWHKVLYD 558
Cdd:TIGR00396 469 WVNVTCPSCGkpalRETDTMDTFAGSSWYYLRYLDPKNTDGPFDKEKAEYWLPVDLYIGGIEHAILHLLYARFFHKFLRD 548
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 559 LGYVNTKEPFKKLINQGIITSFSYQKENGVliPNDQVIEKDNKFFDKKDNKEVTQVIAKMSKSLKNVINPDDIIKEFGAD 638
Cdd:TIGR00396 549 IGYVNTKEPFKKLINQGMVLGFYYPPNGKV--PADVLTERDEKGKDKAGGELVYVGYEKMSKSKGNGIDPQEIVESYGAD 626
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 639 SMRIYEMFMGPLTDSKPWNTKGIIGVFRFLNKIWNLREKELS-----------KENPPREIISELHKVIKKVTEDTEKLN 707
Cdd:TIGR00396 627 ALRLFIMFMGPIAASLEWNESGLEGARRFLDRVWNLVYEITGeldaasltvtaLEEAQKELRRDVHKFLKKVTEDLEKRE 706
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 708 -FNTAISAMMIFINELLKYEK--NYLNIFKPFIIILSPYAPHLAEELWEYIGELPSLFKNSKWPKFDESLIIKGKKEIVL 784
Cdd:TIGR00396 707 sFNTAISAMMELLNKLYKAKKeaLMLEYLKGFVTVLSPFAPHLAEELWEKLGSEPFIIDNAKWPVVDETALVEDKTLIVV 786
|
810 820 830 840 850
....*....|....*....|....*....|....*....|....*....|....*.
gi 6919977 785 QINGKIKDKILLNKETGEKELKEIAMENSKIKSNLLNKKIVKIIVIKNKLVNIVIK 840
Cdd:TIGR00396 787 QVNGKFRAKITVPKDADEEQVEELAKQDPEVKKYLENKTIKKVIYVPGKLVNFVIK 842
|
|
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
2-819 |
0e+00 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 1292.32 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 2 SKYEFIKIEKKWQEFWDNNKTYKVEEDPSIPKekrLYILDMFPYPSANgLHVGHPEGYTATDIFGRYKLLNGFHVLHPIG 81
Cdd:COG0495 3 ERYNPKEIEKKWQKYWEENGTFKADEDSSKPK---YYVLDMFPYPSGR-LHMGHVRNYTIGDVVARYKRMQGYNVLHPMG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 82 FDSFGLPAENYAIQTGTHPQKSTEENINKFKKQIKALGFAYDWDREIRTHEENYYKWTQWIFLQLYKKGLAYVKEMPVWY 161
Cdd:COG0495 79 WDAFGLPAENAAIKNGVHPAEWTYENIANMRRQLKRLGLSYDWSREIATCDPEYYKWTQWIFLQLYEKGLAYRKEAPVNW 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 162 CPELGTVLANEEIIqtsDGpKSERGSYSVEKKYLRQWVLKITKYAERLLDDLEELE-WPESVKEMQRNWIGKSTGVEIEF 240
Cdd:COG0495 159 CPVDQTVLANEQVI---DG-RCWRCGAPVEKKELPQWFLKITDYADELLDDLDKLDgWPEKVKTMQRNWIGRSEGAEVDF 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 241 EIEGHSDKIKVFTTRPDTIFGITYLVIAPENKLIEKITKNNFKQNVLKYVKHEELKSDLNRTSLEKDKSGVFTGSYAFHP 320
Cdd:COG0495 235 PVEGSDEKITVFTTRPDTLFGATFMVLAPEHPLVKELATPEQNAAVAAFIEEAKKKSEIERTSETKEKTGVFTGLYAINP 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 321 ITNEKIPIWVGSYVLGTYGTGAVMGVPAHDERDFQFAKKYQLKILPVISKSGKN--EILEKAFVDDGISINSpNEFNNLK 398
Cdd:COG0495 315 LTGEKIPIWIADYVLMDYGTGAVMAVPAHDQRDFEFAKKYGLPIKQVIAPEDGDdpDILEEAYTGDGVLINS-GEFDGLD 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 399 NSEVKDKVIKWLTKNKKGKEKVAYKLRDWIFSRQRYWGEPIPILFDKLGNAIPLEENDLPLKLPEIANYKPsgTGESPLS 478
Cdd:COG0495 394 SEEAKEAIIEWLEEKGLGKRKVNYRLRDWLISRQRYWGEPIPIIHCEDCGVVPVPEDQLPVELPEDVDFDP--TGGSPLA 471
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 479 RIKDWVNVKD----MGFTRETNTMPQWAGSCWYYLRYLDPKNSKEFANKKKIEYWMPVDLYIGGAEHTVLHLLYSRFWHK 554
Cdd:COG0495 472 RAPEWVNVTCpkcgGPARRETDTMDTFVDSSWYYLRYTDPHNDEAPFDPEAANYWLPVDQYIGGIEHAILHLLYARFFTK 551
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 555 VLYDLGYVNTKEPFKKLINQGIItsfsyqkengvlipndQVIEKDNkffdkkdnkEVTQVIAKMSKSLKNVINPDDIIKE 634
Cdd:COG0495 552 VLRDLGLVSFDEPFKRLLTQGMV----------------LEVGKDG---------VVIGGIEKMSKSKGNVVDPDEIIEK 606
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 635 FGADSMRIYEMFMGPLTDSKPWNTKGIIGVFRFLNKIWNLREKELSKENPP--------REIISELHKVIKKVTEDTEKL 706
Cdd:COG0495 607 YGADTLRLFEMFAGPPERDLEWSDSGVEGAYRFLNRVWRLVVDEAEALKLDvadlseadKELRRALHKTIKKVTEDIERL 686
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 707 NFNTAISAMMIFINELLKYEKNYLN-------IFKPFIIILSPYAPHLAEELWEYIGELPSLFkNSKWPKFDESLIIKGK 779
Cdd:COG0495 687 RFNTAIAALMELVNALYKAKDSGEAdravlreALETLVLLLAPFAPHIAEELWERLGHEGSVA-DAPWPEADEAALVEDE 765
|
810 820 830 840
....*....|....*....|....*....|....*....|
gi 6919977 780 KEIVLQINGKIKDKILLNKETGEKELKEIAMENSKIKSNL 819
Cdd:COG0495 766 VTIVVQVNGKVRGKIEVPADASKEELEAAALADEKVQKFL 805
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
4-815 |
0e+00 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 1169.60 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 4 YEFIKIEKKWQEFWDNNKTYKVEEDPSIPKEKRlYILDMFPYPSANGLHVGHPEGYTATDIFGRYKLLNGFHVLHPIGFD 83
Cdd:PLN02563 80 YPFHEIEPKWQRYWEENRTFRTPDDVDTSKPKF-YVLDMFPYPSGAGLHVGHPEGYTATDILARYKRMQGYNVLHPMGWD 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 84 SFGLPAENYAIQTGTHPQKSTEENINKFKKQIKALGFAYDWDREIRTHEENYYKWTQWIFLQLYKKGLAYVKEMPVWYCP 163
Cdd:PLN02563 159 AFGLPAEQYAIETGTHPKITTLKNIARFRSQLKSLGFSYDWDREISTTEPEYYKWTQWIFLQLLKRGLAYQAEVPVNWCP 238
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 164 ELGTVLANEEIIqtsDGpKSERGSYSVEKKYLRQWVLKITKYAERLLDDLEELEWPESVKEMQRNWIGKSTGVEIEFEI- 242
Cdd:PLN02563 239 ALGTVLANEEVV---DG-LSERGGHPVIRKPMRQWMLKITAYADRLLEDLDDLDWPESIKEMQRNWIGRSEGAELDFSVl 314
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 243 --EGHSD--KIKVFTTRPDTIFGITYLVIAPENKLIEKITKNNFKQNVLKYVKHEELKSDLNRTSLEKDKSGVFTGSYAF 318
Cdd:PLN02563 315 dgEGKERdeKITVYTTRPDTLFGATYLVVAPEHPLLSSLTTAEQKEAVEEYVDAASRKSDLERTELQKEKTGVFTGSYAI 394
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 319 HPITNEKIPIWVGSYVLGTYGTGAVMGVPAHDERDFQFAKKYQLKILPVIS-KSGKNEILEKAFVDDGISINSPN---EF 394
Cdd:PLN02563 395 NPATGEAIPIWVADYVLGSYGTGAIMAVPAHDTRDFEFAQKFDLPIKWVVKpADGNEDDAEKAYTGEGVIVNSSSsglDI 474
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 395 NNLKNSEVKDKVIKWLTKNKKGKEKVAYKLRDWIFSRQRYWGEPIPILF-DKLGNAIPLEENDLPLKLPEIANYKPSGTG 473
Cdd:PLN02563 475 NGLSSKEAAKKVIEWLEETGNGKKKVNYKLRDWLFARQRYWGEPIPVVFlEDSGEPVPVPESDLPLTLPELDDFTPTGTG 554
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 474 ESPLSRIKDWVNVKD----MGFTRETNTMPQWAGSCWYYLRYLDPKNSKEFANKKKIEYWMPVDLYIGGAEHTVLHLLYS 549
Cdd:PLN02563 555 EPPLAKAVSWVNTVDpssgKPARRETNTMPQWAGSCWYYLRFMDPKNSNALVDKEKEKYWMPVDLYVGGAEHAVLHLLYA 634
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 550 RFWHKVLYDLGYVNTKEPFKKLINQGII------TSFSYQKENGV--------------LIPNDQVIEKDNKFFDKKDNK 609
Cdd:PLN02563 635 RFWHKVLYDIGVVSTKEPFQCLVNQGMIlgeveyTAFKDSDGEYVsadtadrlgelqqeKIPEEKVIKSGDSFVLKDDPS 714
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 610 evTQVIA---KMSKSLKNVINPDDIIKEFGADSMRIYEMFMGPLTDSKPWNTKGIIGVFRFLNKIWNL------------ 674
Cdd:PLN02563 715 --IRLIArahKMSKSRGNVVNPDDVVSEYGADSLRLYEMFMGPLRDSKTWSTSGVEGVHRFLGRTWRLvvgaplpdgsfr 792
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 675 REKELSKENPPREIISELHKVIKKVTEDTEKLNFNTAISAMMIFINELLKYEKNYLNIFKPFIIILSPYAPHLAEELWEY 754
Cdd:PLN02563 793 DGTVVTDEEPSLEQLRLLHKCIAKVTEEIESTRFNTAISAMMEFTNAAYKWDKVPREAIEPFVLLLSPYAPHLAEELWFR 872
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6919977 755 IGELPSLFKNSkWPKFDESLIIKGKKEIVLQINGKIKDKILLNKETGEKELKEIAMENSKI 815
Cdd:PLN02563 873 LGHSNSLAYEP-WPEANPSYLVDDTVVLPVQINGKTRGTIEVEEGCSEDDAFALASQDEKL 932
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
36-656 |
7.24e-108 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 333.83 E-value: 7.24e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 36 RLYILDMFPYPSANgLHVGHPEGYTATDIFGRYKLLNGFHVLHPIGFDSFGLPAENYAIQTGTHPQKSTEENINKFKKQI 115
Cdd:cd00812 1 KFYILVMFPYPSGA-LHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFDAFGLPAENAAIKIGRDPEDWTEYNIKKMKEQL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 116 KALGFAYDWDREIRTHEENYYKWTQWIFLQLYKKGLAYVKEMPVWYCpelgtvlaneeiiqtsdgpksergsysvekKYL 195
Cdd:cd00812 80 KRMGFSYDWRREFTTCDPEYYKFTQWLFLKLYEKGLAYKKEAPVNWC------------------------------KLL 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 196 RQWVLKI--TKYAERLLDDLeelewpesvkemqrnwigkstgveiefeieghsDKIKVFttrpdtifgitylviaPENkl 273
Cdd:cd00812 130 DQWFLKYseTEWKEKLLKDL---------------------------------EKLDGW----------------PEE-- 158
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 274 iekiTKNNFkqnvlkyvkheelksdlnrtslekdksgvftgsyafhpitnekipiwvgsyvlgtygtgavmgvpahderd 353
Cdd:cd00812 159 ----VRAMQ----------------------------------------------------------------------- 163
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 354 fqfakkyqlkilpvisksgkneilekafvddgisinspnefnnlknsevkdkvikwltknkkgkekvayklRDWI-FSRQ 432
Cdd:cd00812 164 -----------------------------------------------------------------------ENWIgCSRQ 172
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 433 RYWGEPIPIlfdklgnaipleendlplklpeianykpsgtgesplsrikdwvnvkdmgftreTNTMPQWAGSCWYYLRYL 512
Cdd:cd00812 173 RYWGTPIPW-----------------------------------------------------TDTMESLSDSTWYYARYT 199
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 513 DPKNSKEF------ANKKKIEYWMPVDLYIGGAEHTVLHLLYSRFWHKVLYDLGYVnTKEPFKKLINQGIITSFSyqken 586
Cdd:cd00812 200 DAHNLEQPyegdleFDREEFEYWYPVDIYIGGKEHAPNHLLYSRFNHKALFDEGLV-TDEPPKGLIVQGMVLLEG----- 273
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 587 gvlipndqviekdnkffdkkdnkevtqviAKMSKSLKNVINPDDIIKEFGADSMRIYEMFMGPLTDSKPW 656
Cdd:cd00812 274 -----------------------------EKMSKSKGNVVTPDEAIKKYGADAARLYILFAAPPDADFDW 314
|
|
| tRNA-synt_1_2 |
pfam13603 |
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ... |
227-411 |
7.91e-85 |
|
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ligase or Leucyl-tRNA synthetase, EC:6.1.1.4.
Pssm-ID: 433342 [Multi-domain] Cd Length: 185 Bit Score: 268.26 E-value: 7.91e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 227 RNWIGKSTGVEIEFEIEGHSDKIKVFTTRPDTIFGITYLVIAPENKLIEKITKNNfkQNVLKYVKHEELKSDLNRTSLEK 306
Cdd:pfam13603 1 RNWIGRSEGAEITFPVEGTDEKIEVFTTRPDTLMGVTFVALAPEHPLVEKLAEKN--PEVAAFIEECKNTSEIERTSETK 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 307 DKSGVFTGSYAFHPITNEKIPIWVGSYVLGTYGTGAVMGVPAHDERDFQFAKKYQLKILPVISKSGKNE---ILEKAFVD 383
Cdd:pfam13603 79 EKEGVFTGLYAIHPITGEKIPIWIANFVLMEYGTGAVMAVPAHDQRDFEFAKKYNLPIKPVIQPEDGDLdldIMTEAYTE 158
|
170 180
....*....|....*....|....*...
gi 6919977 384 DGISINSpNEFNNLKNSEVKDKVIKWLT 411
Cdd:pfam13603 159 EGILVNS-GEFDGLDSEEAKEAIIKKLE 185
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
3-775 |
1.42e-72 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 254.98 E-value: 1.42e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 3 KYEFIKIEKKWQEFWDNNKTYKVEEDPSIPKekrlYILDMfPYPSANG-LHVGHPEGYTATDIFGRYKLLNGFHVLHPIG 81
Cdd:TIGR00422 4 DYDPHEVEKKWYKKWEKSGFFKPDGNSNKPP----FCIDI-PPPNVTGsLHIGHALNWSIQDIIARYKRMKGYNVLWLPG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 82 FDSFGLPAEN-----YAIQTGTHPQ-----------KSTEENINKFKKQIKALGFAYDWDREIRTHEENYYKWTQWIFLQ 145
Cdd:TIGR00422 79 TDHAGIATQVkvekkLGAEGKTKHDlgreefrekiwEWKEESGGTIKNQIKRLGASLDWSRERFTMDEGLSKAVKEAFVR 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 146 LYKKGLAYVKEMPVWYCPELGTVLANEEIIqtsdgpksergsysvekkylrqwvlkitkYAERllddleelewpesvkem 225
Cdd:TIGR00422 159 LYEKGLIYRGEYLVNWDPKLNTAISDIEVE-----------------------------YKEV----------------- 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 226 qrnwigKSTGVEIEFEIE-GHSDKIKVFTTRPDTIFGITYLVIAPENKliekitknnfkqnvlKYvKHeelksdlnrtsl 304
Cdd:TIGR00422 193 ------KGKLYYIRYPLAnGSKDYLVVATTRPETMFGDTAVAVHPEDE---------------RY-KH------------ 238
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 305 ekdksgvFTGSYAFHPITNEKIPIWVGSYVLGTYGTGAVMGVPAHDERDFQFAKKYQLKILPVISKSGKneILEKAfvdd 384
Cdd:TIGR00422 239 -------LIGKKVILPLTGRKIPIIADEYVDMEFGTGAVKVTPAHDFNDYEWGKRHNLEFINILDEDGL--LNENA---- 305
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 385 gisinspNEFNNLKNSEVKDKVIKWLTKN-----------------------------------KKGKEKVAY------- 422
Cdd:TIGR00422 306 -------GKYQGLTRFEARKKIVEDLKEEgllvkiephthnvgtcwrsgtvvepllskqwfvkvEKLADKALEaaeegei 378
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 423 ----------------KLRDWIFSRQRYWGEPIPILFDKLGNAIPLEENDLPLKLPeiANYKPSGTgesplsrikdwvnv 486
Cdd:TIGR00422 379 kfvpkrmekrylnwlrNIKDWCISRQLIWGHRIPVWYCKECGEVYVAKEEPLPDDK--TNTGPSVE-------------- 442
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 487 kdmgFTRETNTMPQWAGSCWYYLRYLD-PKNSKEFANkkkieyWMPVDLYIGGaeHTVLhllysRFWhkVLYDL--GYVN 563
Cdd:TIGR00422 443 ----LEQDTDVLDTWFSSSLWPFSTLGwPDETKDLKK------FYPTDLLVTG--YDII-----FFW--VARMIfrSLAL 503
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 564 TKE-PFKKLINQGIItsfsyqkengvlipndqviekdnkfFDkKDNKevtqviaKMSKSLKNVINPDDIIKEFGADSMRI 642
Cdd:TIGR00422 504 TGQvPFKEVYIHGLV-------------------------RD-EQGR-------KMSKSLGNVIDPLDVIEKYGADALRF 550
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 643 YEMFMGPLTDSKPWNTKGIIGVFRFLNKIWN------LREKELSKENPP--------REIISELHKVIKKVTEDTEKLNF 708
Cdd:TIGR00422 551 TLASLVTPGDDINFDWKRVESARNFLNKLWNasrfvlMNLSDDLELSGGeeklsladRWILSKLNRTIKEVRKALDKYRF 630
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 709 NTAISAMMIFI--------NELLKYEKNYLN-------------IFKPFIIILSPYAPHLAEELWEYIGELPSLFKNSKW 767
Cdd:TIGR00422 631 AEAAKALYEFIwndfcdwyIELVKYRLYNGNeaekkaardtlyyVLDKALRLLHPFMPFITEEIWQHFKEGADSIMLQSY 710
|
....*...
gi 6919977 768 PKFDESLI 775
Cdd:TIGR00422 711 PVVDAEFV 718
|
|
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
3-790 |
9.19e-62 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 223.53 E-value: 9.19e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 3 KYEFIKIEKKWQEFWDNNKTYKVEEDPsipkEKRLYILDMFP-YPSANgLHVGHPEGYTATDIFGRYKLLNGFHVLHPIG 81
Cdd:PRK13208 9 KYDPEELEEKWQKIWEEEGTYKFDPDE----RKPVYSIDTPPpTVSGS-LHIGHVFSYTHTDFIARYQRMRGYNVFFPQG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 82 FDSFGLPAENYAIQT-GTHPQ------------KSTEENINKFKKQIKALGFAYDWDREIRTHEENYYKWTQWIFLQLYK 148
Cdd:PRK13208 84 WDDNGLPTERKVEKYyGIRKDdisreefielcrELTDEDEKKFRELWRRLGLSVDWSLEYQTISPEYRRISQKSFLDLYK 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 149 KGLAYVKEMPVWYCPELGTVLANEEIiqtsdgpksergsysvekkylrqwvlkitkyaerllddlEELEWPesvkemqrn 228
Cdd:PRK13208 164 KGLIYRAEAPVLWCPRCETAIAQAEV---------------------------------------EYRERE--------- 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 229 wigkSTGVEIEFEIEGhSDKIKVFTTRPDTIFGITYLVIAPENKliekitknnfkqnvlKYvKHeelksdlnrtslekdk 308
Cdd:PRK13208 196 ----GKLNYIKFPVED-GEEIEIATTRPELLPACVAVVVHPDDE---------------RY-KH---------------- 238
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 309 sgvFTGSYAFHPITNEKIPIWVGSYVLGTYGTGAVM----GvpahDERDFQFAKKYQLKILPVISKSGKneILEKAfvdd 384
Cdd:PRK13208 239 ---LVGKTAIVPLFGVEVPILADPLVDPDFGTGAVMictfG----DKTDVTWWRELNLPTRIIIDEDGR--MTEAA---- 305
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 385 gisinspNEFNNLKNSEVKDKVIK-----------------------------------WLTKNKKGKEKVA-------- 421
Cdd:PRK13208 306 -------GKLAGLTIEEARKKIVEdlksggllgkqepikhnvkfcercdtpleilvtrqWFIKVLDLKEELLergkeinw 378
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 422 ----YKLR----------DWIFSRQRYWGEPIPILF-DKLGNAIPLEENDLPlklpeianYKPsgTGESPLSRIKDwvNV 486
Cdd:PRK13208 379 ypehMRVRlenwieglnwDWCISRQRYFGTPIPVWYcKDCGHPILPDEEDLP--------VDP--TKDEPPGYKCP--QC 446
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 487 KDMGFTRETNTMPQWAGSC---WYYLRYLDPKN--SKEFankkkieywmPVDLYIGGAE-------HTVL--HLLYsrfw 552
Cdd:PRK13208 447 GSPGFEGETDVMDTWATSSitpLIVTGWERDEDlfEKVF----------PMDLRPQGHDiirtwlfYTILraYLLT---- 512
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 553 hkvlydlgyvNTKePFKKlinqgiitsfsyqkengVLIpNDQVIEKDNKffdkkdnkevtqviaKMSKSLKNVINPDDII 632
Cdd:PRK13208 513 ----------GKL-PWKN-----------------IMI-SGMVLDPDGK---------------KMSKSKGNVVTPEELL 548
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 633 KEFGADSMRiYEMFMGPLTDSKPWNTKGIIGVFRFLNKIWNL--------REKELSKENPPRE----IISELHKVIKKVT 700
Cdd:PRK13208 549 EKYGADAVR-YWAASARLGSDTPFDEKQVKIGRRLLTKLWNAsrfvlhfsADPEPDKAEVLEPldrwILAKLAKVVEKAT 627
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 701 EDTEKLNFNTAISAMMIFI------N--ELLK---YEKNYLN-----------IFKPFIIILSPYAPHLAEELWEYIGEl 758
Cdd:PRK13208 628 EALENYDFAKALEEIESFFwhvfcdDylELVKsraYGEDEEEeqksarytlytVLDTLLRLLAPFLPFITEEVWSWLYG- 706
|
890 900 910
....*....|....*....|....*....|....*
gi 6919977 759 pSLFKNSKWPKFDESLIIKG---KKEIVLQINGKI 790
Cdd:PRK13208 707 -GSVHRASWPEPDEELIDEEdeeLGELAKEILSAV 740
|
|
| ileS |
TIGR00392 |
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ... |
3-806 |
1.36e-51 |
|
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ligase and is particularly closely related to the valyl tRNA synthetase. This model may recognize IleS from every species, including eukaryotic cytosolic and mitochondrial forms. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273054 [Multi-domain] Cd Length: 861 Bit Score: 194.52 E-value: 1.36e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 3 KYEFIKIEKKWQEFWDNNKTYkvEEDPSIPKEKRLYILDMFPyPSANG-LHVGHPEGYTATDIFGRYKLLNGFHVLHPIG 81
Cdd:TIGR00392 5 RGNLSKREEKILAFWQENDIF--EKVKKLNKGKPEFIFHDGP-PYANGsIHLGHALNKILKDIILRYKTMQGFNVTRKPG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 82 FDSFGLPAE-----NYAIQTGTHPQKSTEENINK------------FKKQIKALGFAYDWDREIRTHEENYYKWTQWIFL 144
Cdd:TIGR00392 82 WDTHGLPIEhkvekKLGISGKKEISSLEIEEFREkcrefalkqieeQREQFQRLGVWGDWENPYKTMDPSYEESQWWLFK 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 145 QLYKKGLAYVKEMPVWYCPELGTVLANEEIiqtsdgpksergsysvekkylrqwvlkitkyaerllddleelEWPESVKE 224
Cdd:TIGR00392 162 EAHEKGLLYRGLKPVYWSPRCRTALAEAEV------------------------------------------EYKENYKD 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 225 MqrnwigKSTGVEIEFEIEGHSDK--------IKVFTTRPDTIFGITYLVIAPEnklIE--KITKNNFKQNVLKYVK-HE 293
Cdd:TIGR00392 200 V------KDPSIYVKFPVKKDKKTylkvklssLLIWTTTPWTLPSNLAIAVHPD---FEyaLVQDNTKVEYFILAKKlVE 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 294 ELKSDLNR--TSLEKDKSGVFTGSYAFHPITNEK------IPIWVGS-YVLGTYGTGAVMGVPAHDERDFQFAKKYQLKI 364
Cdd:TIGR00392 271 KLYNKAGSdyEIIKTFKGSDLEGLEYEHPLYDFVsqlkegAPVVIGGdHVTTEDGTGIVHTAPGHGEEDYEIGKKYGLEV 350
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 365 L-----------PVISKSGKNEILEKAFVDDG--ISINSPNEFNNL------------------------------KNSE 401
Cdd:TIGR00392 351 LspvdekgvyteGVNDFQGRFVKDADKDIIKAnkIIIEQLKDKGLLlkaekithsyphcwrtktpviyrateqwfiKTKD 430
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 402 VKDKV------IKWLTKNKKGK-EKVAYKLRDWIFSRQRYWGEPIPILFDKLGNAI----PLEENDLPLKLPEIANYKps 470
Cdd:TIGR00392 431 IKDQMleqikkVNWVPEWGEGRfGNWLENRPDWCISRQRYWGIPIPIWYCEDTGEPivvgSIEELIELIELKGIDAWF-- 508
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 471 gtgESPLSRIKDWVNVKDMG---FTRETNTMPQW--AGSCWYYLRYLDPKNSKEFAnkkkieyWMPVDLYIGGAEHTvlh 545
Cdd:TIGR00392 509 ---EDLHRDFLDKITLKSGDggeYRRVPDVLDVWfdSGSMPYASIHYPFENEKFKE-------VFPADFILEGSDQT--- 575
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 546 llysRFWHKVLYDLG-YVNTKEPFKKLINQGIItsfsyqkengvlipndqviekdnkfFDKKDNkevtqviaKMSKSLKN 624
Cdd:TIGR00392 576 ----RGWFYSSLAIGtALFGQAPYKNVITHGFT-------------------------LDEKGR--------KMSKSLGN 618
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 625 VINPDDIIKEFGADSMRIYemfmgpLTDSKPWNT---------------KGII-GVFRFLNKIWNLR-----EKELSKEN 683
Cdd:TIGR00392 619 VVDPLKVINKYGADILRLY------VASSDPWEDlrfsdeilkqvvekyRKIRwNTYRFLLTYANLDkfdplFNSVAVEK 692
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 684 PPRE---IISELHKVIKKVTEDTEKLNFNTAISAMMIFINELL-----------------------KYEKNYLnIFKPFI 737
Cdd:TIGR00392 693 FPEEdrwILSRLNSLVEEVNEALEKYNFHKVLRALQDFIVEELsnwyiriirdrlyceakdndkraAQTTLYY-ALLTLV 771
|
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6919977 738 IILSPYAPHLAEELWEYIGELP---SLFKNsKWPKFDESLIIKgKKEIVLQINGKIKDKILLNKETGEKELK 806
Cdd:TIGR00392 772 RLLAPFLPHTAEEIYQNLPGGEeeeSVHLN-LWPEVDEEFIDE-ALEANMAIVREIVEAFLALRDAANKKLR 841
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
12-643 |
5.26e-51 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 189.16 E-value: 5.26e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 12 KWQEFWDNNKTYKVEEDPSIPKEKrlYILdMFPYPSANG-LHVGHPEGYTATDIFGRYKLLNGFHVLHPIGFDSFGLPAE 90
Cdd:pfam00133 1 QIYEFWDEQGYFKPELEKRKGKPS--FTI-HDGPPNATGsLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPTE 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 91 -----NYAIQTGTHPQKSTEENINKF------------KKQIKALGFAYDWDREIRTHEENYYKWTQWIFLQLYKKGLAY 153
Cdd:pfam00133 78 qvvekKLGIKEKKTRHKYGREEFREKcrewkmeyadeiRKQFRRLGRSIDWDREYFTMDPELEAAVWEVFVRLHDKGLIY 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 154 VKEMPVWYCPELGTVLANEEIiqtsdgpksergsysvekkylrqwvlkitkyaerllddleelEWPESvkemqrnwigKS 233
Cdd:pfam00133 158 RGKKLVNWSPALNTALSNLEV------------------------------------------EYKDV----------KG 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 234 TGVEIEFEIEGHSD-KIKVFTTRPDTIFGITYLVIAPENKLIEKITKNNFKQNVLKYVkheeLKSDLNRTSLEKDKSGVF 312
Cdd:pfam00133 186 PSIHVAFPLADDEGaSLVIWTTTPWTLPGNTAVAVNPEFDYVITGEGYILAEALLKSL----YKKGTDKKILEDFRGKEL 261
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 313 TGSYAFHPITNEKIPIWVGSYVLGTYGTGAVMGVPAHDERDFQFAKKYQLKILPVISksgkneilekafvDDGISINSPN 392
Cdd:pfam00133 262 EGKEAIHPFVNREIPIITDDYVDMEFGTGAVHIAPAHGENDYEVGQRHNLEVINPVD-------------DDGTFTEEAP 328
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 393 EFNNLKNSEVKDKVIKWLTKNK----------------KGKEKVAYKL-------------------------------- 424
Cdd:pfam00133 329 DFQGVYRFDARKKIVELLTEKGlllkiepfthsypfcwRSGTPIIPRAtpqwfvrmdeladqaleavekvqfvpksgekr 408
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 425 --------RDWIFSRQRYWGEPIPILFDKLGNaiplEENDLPLKLPEIANYKPSGTGESPLSR-IKDWVNVKDMGFTRET 495
Cdd:pfam00133 409 yfnwlaniQDWCISRQRWWGHPIPAWVSKDTE----EVVCRGELFELVAGRFEEEGSIKWLHReAKDKLGYGKGTLEQDE 484
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 496 NTMPQW--AGScWYYLRYLDPknskeFANKKKIEYWMPVDLYIGGAEHTvlhllysRFWHKVLYDLG-YVNTKEPFKKLI 572
Cdd:pfam00133 485 DVLDTWfsSGS-WPFSTLGWP-----FVNTEEFKKFFPADMLLEGSDQT-------RGWFYRMIMLStALTGSVPFKNVL 551
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6919977 573 NQGIITSfsyqkENGvlipndqviekdnkffdkkdnkevtqviAKMSKSLKNVINPDDIIKEFGADSMRIY 643
Cdd:pfam00133 552 VHGLVRD-----EQG----------------------------RKMSKSLGNVIDPLDVIDKYGADALRLW 589
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
51-775 |
6.12e-41 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 162.34 E-value: 6.12e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 51 LHVGHPEGYTATDIFGRYKLLNGFHVLHPIGFDSFGLP----AEN---------------YAIQTGTHPQKSTEENI-NK 110
Cdd:PRK12300 1 LHVGHGRTYTIGDVIARYKRMRGYNVLFPMAFHVTGTPilgiAERiargdpetielykslYGIPEEELEKFKDPEYIvEY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 111 FKKQI----KALGFAYDWDREIRTHEENYYKWTQWIFLQLYKKGLAYVKEMPVWYCPELGTVlaneeiiqtsdgpkserg 186
Cdd:PRK12300 81 FSEEAkedmKRIGYSIDWRREFTTTDPEYSKFIEWQFRKLKEKGLIVKGSHPVRYCPNDNNP------------------ 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 187 sysVEKkylrqwvlkitkyaerllDDLEELEWPEsvkemqrnwIGKSTGveIEFEIEGHSDkIKVFTTRPDTIFGITYLV 266
Cdd:PRK12300 143 ---VGD------------------HDLLDGEEPE---------IVEYTL--IKFEESEDLI-LPAATLRPETIFGVTNLW 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 267 IAPENKLIeKITKNNFKQNVLKYVkHEELK-SDLNRTSLEKDKSGVFTGSYAFHPITNEKIPIWVGSYVLGTYGTGAVMG 345
Cdd:PRK12300 190 VNPDATYV-KAEVDGEKWIVSKEA-AEKLSfQDRDVEIIEEIKGSELIGKKVKNPVTGKEVPILPADFVDPDNGTGVVMS 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 346 VPAHDERDF--------QFAKKYQLKILPVIS------------------KSGKNEILEKAFVD-------DGISINSPN 392
Cdd:PRK12300 268 VPAHAPYDYvalrdlkkNKELLDVIEPIPLIEvegygefpakevveklgiKSQEDPELEEATKEvyraefhKGVLKENTG 347
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 393 EFNNLKNSEVKDKVIKWLTKNKKG-------------------------------------KEKvAYK------------ 423
Cdd:PRK12300 348 EYAGKPVREAREKITKDLIEKGIAdimyefsnrpvycrcgtecvvkvvkdqwfidysdpewKEL-AHKaldnmeiipeey 426
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 424 ----------LRDWIFSRQRYWGEPIPilFDK------LG----------NAIPLEENDL-PLKL-PEIANYKPSGTGEs 475
Cdd:PRK12300 427 rkefentidwLKDRACARRRGLGTRLP--WDEewiiesLSdstiymayytIAHKIREYGIkPEQLtPEFFDYVFLGKGD- 503
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 476 pLSRIKdwvnvKDMGFTRET-NTMpqwagscwyylryldpknSKEFankkkiEYWMPVDLYIGGAEHTVLHLLYSRFWHK 554
Cdd:PRK12300 504 -PEEVS-----KKTGIPKEIlEEM------------------REEF------LYWYPVDWRHSGKDLIPNHLTFFIFNHV 553
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 555 VLYDlgyvntkepfKKLINQGIITsfsyqkeNGVLIPNDQviekdnkffdkkdnkevtqviaKMSKSLKNVINPDDIIKE 634
Cdd:PRK12300 554 AIFP----------EEKWPRGIVV-------NGFVLLEGK----------------------KMSKSKGNVIPLRKAIEE 594
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 635 FGADSMRIYEMFMGPLTDSKPWNTKGIIGVFRFLNKIWNL--REKELSKENPPREI----ISELHKVIKKVTEDTEKLNF 708
Cdd:PRK12300 595 YGADVVRLYLTSSAELLQDADWREKEVESVRRQLERFYELakELIEIGGEEELRFIdkwlLSRLNRIIKETTEAMESFQT 674
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6919977 709 NTAISAMMIFINELLKY-------EKNYL--NIFKPFIIILSPYAPHLAEELWEYIGElPSLFKNSKWPKFDESLI 775
Cdd:PRK12300 675 RDAVQEAFYELLNDLRWylrrvgeANNKVlrEVLEIWIRLLAPFTPHLAEELWHKLGG-EGFVSLEKWPEPDESKI 749
|
|
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
3-775 |
1.59e-39 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 157.93 E-value: 1.59e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 3 KYEFIKIEKKWQEFWDNNKTYK--VEEDpsipKEKRLYILdmfpY---PSANGL-HVGHPEGYTATDIFGRYKLLNGFHV 76
Cdd:COG0060 15 RANLPKREPEILKFWEENDIYEksREAR----AGRPKFVL----HdgpPYANGDiHIGHALNKILKDIIVRYKTMRGFDV 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 77 LHPIGFDSFGLPAENYAIQ----TGTHPQK------------STEENINKFKKQIKALGFAYDWDreirtheeNYYK--- 137
Cdd:COG0060 87 PYVPGWDCHGLPIELKVEKelgiKKKDIEKvgiaefrekcreYALKYVDEQREDFKRLGVWGDWD--------NPYLtmd 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 138 -------WtqWIFLQLYKKGLAYVKEMPVWYCPELGTVLANEEiiqtsdgpksergsysVEkkylrqwvlkitkYAERll 210
Cdd:COG0060 159 peyeesiW--WALKKLYEKGLLYKGLKPVPWCPRCGTALAEAE----------------VE-------------YKDV-- 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 211 ddleelewpesvkemqrnwigKSTGVEIEFEIEGHSDKIK-------VFTTRPDTIFG---------ITYLVIAPEN--- 271
Cdd:COG0060 206 ---------------------TSPSIYVKFPVKDEKALLLledaylvIWTTTPWTLPAnlavavhpdIDYVLVEVTGger 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 272 -----KLIEKITKNNFKQN--VLKYVKHEELKsdlnrtslekdksgvftGSYAFHPITNEKI-----PIWVGSYVLGTYG 339
Cdd:COG0060 265 lilaeALVEAVLKELGIEDyeVLATFKGAELE-----------------GLRYEHPFYYVVGydrahPVILGDYVTTEDG 327
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 340 TGAVMGVPAHDERDFQFAKKYQLKILPVISKSGKneilekaFVDD-----GISINSPNE--FNNLKN------------- 399
Cdd:COG0060 328 TGIVHTAPGHGEDDFEVGKKYGLPVLNPVDDDGR-------FTEEaplfaGLFVKDANPaiIEDLKErgallarekiths 400
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 400 -----------------------SEVKDKV------IKWLTKNKKGKEK--VAyKLRDWIFSRQRYWGEPIPI------- 441
Cdd:COG0060 401 yphcwrcktpliyratpqwfismDKLRDRAleaiekVNWIPEWGEGRFGnmLE-NRPDWCISRQRYWGVPIPIwvcedcg 479
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 442 --------------LFDKLG----NAIPLEENDLPlklPEIANYKPSGTgesplsrikdwvnvkdmgFTRETNTMPQW-- 501
Cdd:COG0060 480 elhrteevigsvaeLLEEEGadawFELDLHRPFLD---ETLKCPKCGGT------------------MRRVPDVLDVWfd 538
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 502 AGSCWYylryldpknskeFANKKKIEYWMPVDLYiggAE---------HTvLHLLYSrfwhkVLYDlgyvntKEPFKKLI 572
Cdd:COG0060 539 SGSMHF------------AVLENREELHFPADFY---LEgsdqtrgwfYS-SLLTST-----ALFG------RAPYKNVL 591
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 573 NQGIitsfsyqkengVLipndqviekdnkffDKKDNKevtqviakMSKSLKNVINPDDIIKEFGADSMRIYeMFMGPLTD 652
Cdd:COG0060 592 THGF-----------VL--------------DEDGRK--------MSKSLGNVVDPQEVIDKYGADILRLW-VASSDYWG 637
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 653 SKPWNTKGIIGVFRFLNKIWN-LR------------EKELSKENPP---REIISELHKVIKKVTEDTEKLNFNTAISAMM 716
Cdd:COG0060 638 DLRFSDEILKEVRDVYRRLRNtYRfllanlddfdpaEDAVPYEDLPeldRWILSRLNELIKEVTEAYDNYDFHRAYRALH 717
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 717 IFINELL-------------KYEKNYLN----------IFKPFIIILSPYAPHLAEELWEYigeLPSLFKNS----KWPK 769
Cdd:COG0060 718 NFCVEDLsnwyldiskdrlyTEAADSLDrraaqttlyeVLETLVRLLAPILPFTAEEIWQN---LPGEAEESvhlaDWPE 794
|
....*.
gi 6919977 770 FDESLI 775
Cdd:COG0060 795 VDEELI 800
|
|
| Anticodon_Ia_Leu_BEm |
cd07958 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; ... |
656-753 |
7.74e-38 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes bacterial and eukaryotic mitochondrial members, as well as LeuRS from the archaeal Halobacteria. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153412 [Multi-domain] Cd Length: 117 Bit Score: 136.97 E-value: 7.74e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 656 WNTKGIIGVFRFLNKIWNLREKELSKENPP----------REIISELHKVIKKVTEDTEKLNFNTAISAMMIFINELLKY 725
Cdd:cd07958 1 WSDSGVEGAYRFLNRVWRLVTELAEALAAPaaaaelseedKELRRKLHKTIKKVTEDIERLRFNTAIAALMELVNALYKY 80
|
90 100 110
....*....|....*....|....*....|....*
gi 6919977 726 EKN-------YLNIFKPFIIILSPYAPHLAEELWE 753
Cdd:cd07958 81 KKKdaqhaavLREALETLVLLLAPFAPHIAEELWE 115
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
2-782 |
8.23e-33 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 136.39 E-value: 8.23e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 2 SKYEFIKIEKKWQEFWDNNKTYKveedpSIPKEKRLY-IldMFPYPSANG-LHVGHpeGYTAT--DIFGRYKLLNGFHVL 77
Cdd:PRK05729 7 KTYDPKEVEAKWYQKWEEKGYFK-----PDDNSKKPFsI--VIPPPNVTGsLHMGH--ALNNTlqDILIRYKRMQGYNTL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 78 HPIGFDSFG----------LPAENyaiqtgthpqKS----------------TEENINKFKKQIKALGFAYDWDREIRTH 131
Cdd:PRK05729 78 WLPGTDHAGiatqmvverqLAAEG----------KSrhdlgrekflekvwewKEESGGTITNQLRRLGASCDWSRERFTM 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 132 EENYYKWTQWIFLQLYKKGLAYVKEMPVWYCPELGTVLANEEIIQtsdgpKSERGS-YSVekkylrqwvlkitKYAerll 210
Cdd:PRK05729 148 DEGLSKAVREVFVRLYEKGLIYRGKRLVNWDPKLQTALSDLEVEY-----KEVKGKlWHI-------------RYP---- 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 211 ddleelewpesvkemqrnwigkstgveiefeIEGHSDKIKVFTTRPDTIFGITYLVIAPENKliekitknnfkqnvlKYv 290
Cdd:PRK05729 206 -------------------------------LADGSDYLVVATTRPETMLGDTAVAVNPEDE---------------RY- 238
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 291 KHeelksdlnrtslekdksgvFTGSYAFHPITNEKIPIWVGSYVLGTYGTGAVMGVPAHDERDFQFAKKYQLKILPVISK 370
Cdd:PRK05729 239 KH-------------------LIGKTVILPLVGREIPIIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINIMDE 299
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 371 SGKneilekafvddgisINS-PNEFNNLKNSEVKDKVIKWLTKN------------------------------------ 413
Cdd:PRK05729 300 DGT--------------INEnPGEYQGLDRFEARKAIVADLEELgllvkiephthsvghsdrsgvviepylsdqwfvkmk 365
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 414 ----------KKGK--------EKVAY----KLRDWIFSRQRYWGEPIPILFDKLGNAIPLEEndlplklpeianyKPSG 471
Cdd:PRK05729 366 plakpaleavENGEikfvperwEKTYFhwmeNIQDWCISRQLWWGHRIPAWYDEDGEVYVGRE-------------EPEA 432
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 472 TGESPLSRIKDwvnVKD------------MGftretntmpqwagscWyylryldPKNSKEFankkkiEYWMPVDLYIGGa 539
Cdd:PRK05729 433 REKALLTQDED---VLDtwfssalwpfstLG---------------W-------PEKTEDL------KRFYPTSVLVTG- 480
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 540 ehtvlhllysrfwhkvlYD-----------LGYVNTKE-PFKKLINQGIItsfsyqkengvlipndqvieKDnkffdkKD 607
Cdd:PRK05729 481 -----------------FDiiffwvarmimMGLHFTGQvPFKDVYIHGLV--------------------RD------EQ 517
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 608 NKevtqviaKMSKSLKNVINPDDIIKEFGADSMRIYEMFMGPLTDSKPWNTKGIIGVFRFLNKIWN--------LREKEL 679
Cdd:PRK05729 518 GR-------KMSKSKGNVIDPLDLIDKYGADALRFTLAALASPGRDIRFDEERVEGYRNFANKLWNasrfvlmnLEGADV 590
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 680 SKENPPRE-------IISELHKVIKKVTEDTEKLNFNTAISAMMIFIN--------ELLK---YEKNY-------LNIFK 734
Cdd:PRK05729 591 GELPDPEElsladrwILSRLNRTVAEVTEALDKYRFDEAARALYEFIWnefcdwylELAKpvlQEAAKratratlAYVLE 670
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|
gi 6919977 735 PFIIILSPYAPHLAEELWEYIGELPSLFK--NSKWPKFDESLIIKGKKEI 782
Cdd:PRK05729 671 QILRLLHPFMPFITEELWQKLAPLGIEESimLAPWPEADEAIDEAAEAEF 720
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
38-233 |
1.74e-32 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 130.06 E-value: 1.74e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 38 YILDMfPYPSANG-LHVGHPEGYTATDIFGRYKLLNGFHVLHPIGFDSFGLPAENY-----AIQTGT-----------HP 100
Cdd:cd00817 3 FVIDT-PPPNVTGsLHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIATQVVvekklGIEGKTrhdlgreefleKC 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 101 QKSTEENINKFKKQIKALGFAYDWDREIRTHEENYYKWTQWIFLQLYKKGLAYVKEMPVWYCPELGTVLANEEIiqtsdg 180
Cdd:cd00817 82 WEWKEESGGKIREQLKRLGASVDWSREYFTMDPGLSRAVQEAFVRLYEKGLIYRDNRLVNWCPKLRTAISDIEV------ 155
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 6919977 181 pkSERGSYSVEKKYLRQWVLKITKYAERLLDDLEE--LEW-PESVKEMQRNWIGKS 233
Cdd:cd00817 156 --CSRSGDVIEPLLKPQWFVKVKDLAKKALEAVKEgdIKFvPERMEKRYENWLENI 209
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
44-230 |
1.60e-27 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 114.17 E-value: 1.60e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 44 PYPSANgLHVGHPEGYTATDIFGRYKLLNGFHVLHPIGFDSFGLPAENYAIQTGTHPQKSTEENINKFKKQIKALGFAYd 123
Cdd:cd00814 9 PYVNGV-PHLGHLYGTVLADVFARYQRLRGYDVLFVTGTDEHGTKIEQKAEEEGVTPQELCDKYHEIFKDLFKWLNISF- 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 124 wDREIRTHEENYYKWTQWIFLQLYKKGLAYVKEMPVWYCPELGTVLAneeiiqtsdgpksergsysvEKKYLRQWVLKIT 203
Cdd:cd00814 87 -DYFIRTTSPRHKEIVQEFFKKLYENGYIYEGEYEGLYCVSCERFLP--------------------EWREEEHYFFRLS 145
|
170 180 190
....*....|....*....|....*....|
gi 6919977 204 KYAERLLDDLEE---LEWPESVKEMQRNWI 230
Cdd:cd00814 146 KFQDRLLEWLEKnpdFIWPENARNEVLSWL 175
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
4-768 |
8.05e-27 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 117.79 E-value: 8.05e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 4 YEFIKIEKKWQEFWDNNKTYKVEEDPSipkeKRLYILDMFPYPSANG-LHVGHPEGYTATDIFGRYKLLNGFHVLHPIGF 82
Cdd:PRK14900 19 YEHREVEARWYPFWQERGYFHGDEHDR----TRPPFSIVLPPPNVTGsLHLGHALTATLQDVLIRWKRMSGFNTLWLPGT 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 83 DSFGLPAENYAIQTGTHPQKSTEENI-----------------NKFKKQIKALGFAYDWDREIRTHEENYYKWTQWIFLQ 145
Cdd:PRK14900 95 DHAGIATQMIVEKELKKTEKKSRHDLgreaflervwawkeqygSRIGEQHKALGASLDWQRERFTMDEGLSRAVREVFVR 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 146 LYKKGLAYVKEMPVWYCPELGTVLANEEIiqtsDGPKSERGSysvekkylrqwvlkITKYAERLLDDLEElewpesvkem 225
Cdd:PRK14900 175 LHEEGLIYREKKLINWCPDCRTALSDLEV----EHEEAHQGE--------------LWSFAYPLADGSGE---------- 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 226 qrnwigkstgveiefeieghsdkIKVFTTRPDTIFGITYLVIAPENKliekitknnfkqnvlkyvKHEELksdlnrtsle 305
Cdd:PRK14900 227 -----------------------IVVATTRPETMLGDTAVAVHPLDP------------------RYMAL---------- 255
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 306 kdksgvfTGSYAFHPITNEKIPIWVGSYVLG-TYGTGAVMGVPAHDERDFQFAKKYQLKILPVISKSGK----------- 373
Cdd:PRK14900 256 -------HGKKVRHPITGRTFPIVADAILVDpKFGTGAVKVTPAHDFNDFEVGKRHGLEMITVIGPDGRmtaeagplagl 328
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 374 ---------NEILEKAFVDDGISINSPNEFNNLKNSEVKDKVI--KWLTK-----------NKKGKEKV-------AY-- 422
Cdd:PRK14900 329 drfearkevKRLLAEQGLDRGAKPHVLPLGRCQRSATILEPLLsdQWYVRieplarpaieaVEQGRTRFipeqwtnTYma 408
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 423 ---KLRDWIFSRQRYWGEPIPILFdklgnaipleendLPLKLPEIANYKPSGTGESPLSRIKDWVNVKDMGFTretntmp 499
Cdd:PRK14900 409 wmrNIHDWCISRQLWWGHQIPAWY-------------CPDGHVTVARETPEACSTCGKAELRQDEDVLDTWFS------- 468
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 500 qwaGSCWYYLRYLDPKNSKEfankkkIEYWMPVDLYIGGaeHTVLHLLYSRFWHKVLYDLGYVntkePFKKLINQGIIts 579
Cdd:PRK14900 469 ---SGLWPFSTMGWPEQTDT------LRTFYPTSVMETG--HDIIFFWVARMMMMGLHFMGEV----PFRTVYLHPMV-- 531
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 580 fsyQKENGvlipndqviekdnkffdkkdnkevtqviAKMSKSLKNVINPDDIIKEFGADSMRIYemfMGPLT----DSKP 655
Cdd:PRK14900 532 ---RDEKG----------------------------QKMSKTKGNVIDPLVITEQYGADALRFT---LAALTaqgrDIKL 577
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 656 WNTKgIIGVFRFLNKIW--------NLREKELSKENPP--------REIISELHKVIKKVTEDTEKLNFNTAISAMMIFI 719
Cdd:PRK14900 578 AKER-IEGYRAFANKLWnasrfalmNLSGYQERGEDPArlartpadRWILARLQRAVNETVEALEAFRFNDAANAVYAFV 656
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 720 -NEL------LKYEKNY--------------LNIFKPFIIILSPYAPHLAEELWEyigELPSLFKNSKWP 768
Cdd:PRK14900 657 wHELcdwyieLAKEALAsedpearrsvqavlVHCLQTSYRLLHPFMPFITEELWH---VLRAQVGASAWA 723
|
|
| PLN02943 |
PLN02943 |
aminoacyl-tRNA ligase |
10-769 |
9.29e-27 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215509 [Multi-domain] Cd Length: 958 Bit Score: 117.35 E-value: 9.29e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 10 EKKWQEFWDNNKTYKveedPSIPKEKRLYILDMfPYPSANG-LHVGHPEGYTATDIFGRYKLLNGFHVLHPIGFDSFG-- 86
Cdd:PLN02943 66 EERIYNWWESQGYFK----PNFDRGGDPFVIPM-PPPNVTGsLHMGHAMFVTLEDIMVRYNRMKGRPTLWIPGTDHAGia 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 87 --LPAENYAIQTGThpqKSTEENINKFKK---------------QIKALGFAYDWDREIRTHEENYYKWTQWIFLQLYKK 149
Cdd:PLN02943 141 tqLVVEKMLASEGI---KRTDLGRDEFTKrvwewkekyggtitnQIKRLGASCDWSRERFTLDEQLSRAVVEAFVRLHEK 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 150 GLAYVKEMPVWYCPELGTVLANEEIiqtsdgpksergSYSVEKKYLRQwvlkitkyaerllddleelewpesvkemqrnw 229
Cdd:PLN02943 218 GLIYQGSYMVNWSPNLQTAVSDLEV------------EYSEEPGTLYY-------------------------------- 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 230 igkstgveIEFEIEGHS-DKIKVFTTRPDTIFGITYLVIAPENKliekitknnfkqnvlKYVKheelksdlnrtslekdk 308
Cdd:PLN02943 254 --------IKYRVAGGSeDFLTIATTRPETLFGDVAIAVNPEDD---------------RYSK----------------- 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 309 sgvFTGSYAFHPIT-NEKIPIWVGSYVLGTYGTGAVMGVPAHDERDFQFAKKYQLKILPVISKSGkneilekafvddgis 387
Cdd:PLN02943 294 ---YIGKMAIVPMTyGRHVPIIADRYVDKDFGTGVLKISPGHDHNDYLLARKLGLPILNVMNKDG--------------- 355
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 388 inSPNEFNNLKNSEVKDKVIKWLTKNKKGKEKVAYKLRdwiFSRQRYWGEPIPILFDKLGNAI--PLEENDL-------- 457
Cdd:PLN02943 356 --TLNEVAGLYWFEAREKLWSDLEETGLAVKKEPHTLR---VPRSQRGGEVIEPLVSKQWFVTmePLAEKALkavengel 430
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 458 ---PLKLPEIANYKpsgtgespLSRIKDWVNVKDMgftretntmpqWAG---SCWYYL------RYLDPKNSKEFANKKK 525
Cdd:PLN02943 431 tiiPERFEKIYNHW--------LSNIKDWCISRQL-----------WWGhriPVWYIVgkdceeDYIVARSAEEALEKAR 491
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 526 IEYWMPVDLYiggAEHTVLHLLYSR-FWHkvLYDLGYVNT-KEPFKK--------------------LINQGI----ITS 579
Cdd:PLN02943 492 EKYGKDVEIY---QDPDVLDTWFSSaLWP--FSTLGWPDVsAEDFKKfypttvletghdilffwvarMVMMGIeftgTVP 566
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 580 FSYQKENGvLIPNDQViekdnkffdkkdnkevtqviAKMSKSLKNVINPDDIIKEFGADSMRiYEMFMGPLTDSKPWNTK 659
Cdd:PLN02943 567 FSYVYLHG-LIRDSQG--------------------RKMSKTLGNVIDPLDTIKEFGTDALR-FTLALGTAGQDLNLSTE 624
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 660 GIIGVFRFLNKIWN--------------------LREKELSKEN-------PPREIISELHKVIKKVTEDTEKLNFNTAI 712
Cdd:PLN02943 625 RLTSNKAFTNKLWNagkfvlqnlpsqsdtsawehILACKFDKEEsllslplPECWVVSKLHELIDSVTTSYDKYFFGDVG 704
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6919977 713 SAMMIFI-------------NELLKYEKNY---------LNIFKPFIIILSPYAPHLAEELWEYIGELPSLFKNSKWPK 769
Cdd:PLN02943 705 REIYDFFwsdfadwyieaskTRLYHSGDNSalsraqavlLYVFENILKLLHPFMPFVTEELWQALPYRKEALIVSPWPQ 783
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
36-230 |
1.96e-26 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 110.59 E-value: 1.96e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 36 RLYILDMFPYPSANgLHVGHPEGYTATDIFGRYKLLNGFHVLHPIGFDSFGLPAENYAIQTGTH-------------PQK 102
Cdd:cd00668 1 KFYVTTPPPYANGS-LHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAERKGGRkkktiwieefredPKE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 103 STEENINKFKKQIKALGFAYDWDREIRTHEENYYKWTQWIFLQLYKKGLAYvkempvwycpelgtvlaneeiiqtsdgpk 182
Cdd:cd00668 80 FVEEMSGEHKEDFRRLGISYDWSDEYITTEPEYSKAVELIFSRLYEKGLIY----------------------------- 130
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 6919977 183 seRGSYSVEKKylRQWVLKITKYAERLLDDLEELEW-PESVKEMQRNWI 230
Cdd:cd00668 131 --RGTHPVRIT--EQWFFDMPKFKEKLLKALRRGKIvPEHVKNRMEAWL 175
|
|
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ... |
1-775 |
3.43e-26 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440291 [Multi-domain] Cd Length: 877 Bit Score: 115.53 E-value: 3.43e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 1 MSK-YEFIKIEKKWQEFWDNNKTYKVEEDP-----SIpkekrlyildMFPYPSANG-LHVGHPEGYTATDIFGRYKLLNG 73
Cdd:COG0525 3 LPKtYDPKEVEAKWYQYWEENGYFKADPDSdkepfTI----------VIPPPNVTGsLHMGHALNNTLQDILIRYKRMQG 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 74 FHVLHPIGFDSFGlpaenyaIQTgthpQ-----KSTEENINKF----------------------KKQIKALGFAYDWDR 126
Cdd:COG0525 73 YNTLWQPGTDHAG-------IAT----QavverQLAEEGKSRHdlgrekflervwewkeesggtiTNQLRRLGASCDWSR 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 127 EIRTHEENYYKWTQWIFLQLYKKGLAYVKEMPVWYCPELGTVLANEEIIQtsdgpKSERGS-YSVekkylrqwvlkitKY 205
Cdd:COG0525 142 ERFTMDEGLSKAVREVFVRLYEKGLIYRGKRLVNWDPKLKTALSDLEVEH-----EEVKGHlWHI-------------RY 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 206 aerllddleelewpesvkemqrnwigkstgveiefEIEGHSDKIKVFTTRPDTIFGITYLVIAPENKliekitknnfkqn 285
Cdd:COG0525 204 -----------------------------------PLADGSGYIVVATTRPETMLGDTAVAVHPEDE------------- 235
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 286 vlKYvKHeelksdlnrtslekdksgvFTGSYAFHPITNEKIPIwVG-SYVLGTYGTGAVMGVPAHDERDFQFAKKYQLKI 364
Cdd:COG0525 236 --RY-KH-------------------LIGKTVILPLVGREIPI-IAdEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPM 292
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 365 LPVISKSGK-NEILE-----------KAFVDDgisinspnefnnLKNS----EVKDKVIK-------------WLTKN-- 413
Cdd:COG0525 293 INILDEDGTiNENAGkyrgldrfearKAIVAD------------LEELgllvKVEPHKHSvghsdrsgtviepYLSDQwf 360
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 414 --------------KKGK--------EKVaYK-----LRDWIFSRQRYWGEPIPILFDKLGNAIpLEENDlplklPEian 466
Cdd:COG0525 361 vkmkplakpaieavEDGEikfvperwEKT-YFhwmenIRDWCISRQLWWGHRIPAWYCPDGEVY-VARTE-----PE--- 430
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 467 yKPSGTGESPLSRIKDwvnVKD------------MGftretntmpqwagscWyylryldPKNSKEFankkkiEYWMPVDL 534
Cdd:COG0525 431 -ACAKAGSVNLTQDED---VLDtwfssalwpfstLG---------------W-------PEKTEDL------KYFYPTSV 478
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 535 YIGGaehtvlhllysrfwhkvlYD-----------LGYVNTKE-PFKKLINQGIItsfsyqkengvlipndqviekdnkf 602
Cdd:COG0525 479 LVTG------------------FDiiffwvarmimMGLHFTGEvPFKDVYIHGLV------------------------- 515
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 603 FDKKDnkevtqviAKMSKSLKNVINPDDIIKEFGADSMRIYEMFMGPLTDSKPWNTKGIIGVFRFLNKIWN--------- 673
Cdd:COG0525 516 RDEQG--------RKMSKSKGNVIDPLDLIDKYGADALRFTLAALASPGRDIKFDEERVEGYRNFANKLWNasrfvlmnl 587
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 674 --------LREKELSKENppREIISELHKVIKKVTEDTEKLNFNTAisAMMI--FI-N-------ELLK---YEKNY--- 729
Cdd:COG0525 588 egfdpgldPDPEELSLAD--RWILSRLNKTIAEVTEALEKYRFDEA--AQALydFVwNefcdwylELAKprlYGGDEaak 663
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|....*.
gi 6919977 730 -------LNIFKPFIIILSPYAPHLAEELWEYIGELP---SLFKnSKWPKFDESLI 775
Cdd:COG0525 664 retratlVYVLEQILRLLHPFMPFITEEIWQKLPPRKegeSIML-APWPEADEELI 718
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
43-230 |
3.81e-26 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 111.61 E-value: 3.81e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 43 FPYPSANgLHVGHPEGYTATDIFGRYKLLNGFHVLHPIGFDSFGLPAENYAIQTGTHPQKSTEENINKFKKQIKALGFAY 122
Cdd:pfam09334 7 LPYANGP-PHLGHLYSYIPADIFARYLRLRGYDVLFVCGTDEHGTPIELKAEKEGITPEELVDRYHEIHREDFKKFNISF 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 123 DwdREIRTHEENYYKWTQWIFLQLYKKGLAYVKEMPVWYCPELGTVLANEEII----------QTSD------------- 179
Cdd:pfam09334 86 D--DYGRTTSERHHELVQEFFLKLYENGYIYEKEIEQFYCPSDERFLPDRYVEgtcphcgsedARGDqcencgrhlepte 163
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 6919977 180 --GPKSERGSYSVEKKYLRQWVLKITKYAERLLDDLEE--LEWPESVKEMQRNWI 230
Cdd:pfam09334 164 liNPKCVICGTTPEVKETEHYFFDLSKFQDKLREWIEEnnPEWPENVKNMVLEWL 218
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
10-773 |
2.95e-23 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 106.39 E-value: 2.95e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 10 EKKWQEFWDNNKTYK--VEEDPSIPkekrlYIL-DMFPYpsANG-LHVGHPEGYTATDIFGRYKLLNGFHVLHPIGFDSF 85
Cdd:PLN02843 9 EPEIQKLWEENQVYKrvSDRNNGES-----FTLhDGPPY--ANGdLHIGHALNKILKDFINRYQLLQGKKVHYVPGWDCH 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 86 GLPAENYAIQtgTHPQKSTEE----------------NINKFKKQIKALGFAYDWDREIRTHEENYYKWTQWIFLQLYKK 149
Cdd:PLN02843 82 GLPIELKVLQ--SLDQEARKEltpiklrakaakfakkTVDTQRESFKRYGVWGDWENPYLTLDPEYEAAQIEVFGQMFLN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 150 GLAYVKEMPVWYCPELGTVLANEEiIQTSDGPKSErgsySVekkYLrqwVLKITKYAERLLDDLEELewpesvkemqrnw 229
Cdd:PLN02843 160 GYIYRGRKPVHWSPSSRTALAEAE-LEYPEGHVSK----SI---YV---AFPVVSPSETSPEELEEF------------- 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 230 igkstgveiefeIEGHSdkIKVFTTRPDTIFG---------ITYLVIAPENKLIEKITKNNFK----------QNVLKYV 290
Cdd:PLN02843 216 ------------LPGLS--LAIWTTTPWTMPAnaavavndkLQYSVVEVQSFSEDESTSGGNKkkrpgnvlkeQQKLFLI 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 291 KHEELKSDL-NRTSLEKDKSGVFTGS------YAfHPITNEKIPIWV-GSYVLGTYGTGAVMGVPAHDERDFQFAKKYQL 362
Cdd:PLN02843 282 VATDLVPALeAKWGVKLVVLKTFPGSdlegcrYI-HPLYNRESPVVIgGDYITTESGTGLVHTAPGHGQEDYITGLKYGL 360
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 363 KILPVISKSGK-----------------NEILEKAFVDDGISIN----------------------------SPNEFNNL 397
Cdd:PLN02843 361 PLLSPVDDAGKfteeagqfsglsvlgegNAAVVEALDEAGSLLMeeayghkypydwrtkkptifrateqwfaSVEGFRQA 440
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 398 KNSEVKDkvIKWLTKNKKGKEKVAYKLR-DWIFSRQRYWGEPIPILFDKLGNAiPLEENDLPLKLPEIANYKPSGTgesp 476
Cdd:PLN02843 441 ALDAIDK--VKWIPAQGENRIRAMVSGRsDWCISRQRTWGVPIPVFYHVETKE-PLMNEETIAHVKSIVAQKGSDA---- 513
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 477 lsrikdW--VNVKDM----------GFTRETNTMPQW--AGSCWyylryldpknSKEFANKKKIEYwmPVDLYIGGAEHt 542
Cdd:PLN02843 514 ------WwyMDVEDLlpekyrdkasDYEKGTDTMDVWfdSGSSW----------AGVLGSREGLSY--PADLYLEGSDQ- 574
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 543 vlHllysRFWHK--VLYDLGyVNTKEPFKKLINQGIitsfsyqkengVLipndqviekDNKFFdkkdnkevtqviaKMSK 620
Cdd:PLN02843 575 --H----RGWFQssLLTSVA-TKGKAPYKSVLTHGF-----------VL---------DEKGF-------------KMSK 614
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 621 SLKNVINPDDII------KE---FGADSMRIY--------EMFMGP-----LTDSkpwnTKGIIGVFRFLnkIWNLR--- 675
Cdd:PLN02843 615 SLGNVVDPRLVIeggknqKQepaYGADVLRLWvasvdytgDVLIGPqilkqMSDI----YRKLRGTLRYL--LGNLHdwk 688
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 676 -EKELSKENPP---REIISELHKVIKKVTEDTEKLNFNTAISAMMIFI-----NELLKYEKNYLNIFKP----------- 735
Cdd:PLN02843 689 pDNAVPYEDLPsidKYALFQLENVVNEIEESYDNYQFFKIFQILQRFTivdlsNFYLDVAKDRLYVGGTtsftrrscqtv 768
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|....
gi 6919977 736 -------FIIILSPYAPHLAEELWEyigELP---------SLFkNSKWPKFDES 773
Cdd:PLN02843 769 laahllsLLRAIAPILPHLAEDAWQ---NLPfqedgsaaeSVF-EAGWPTPNEE 818
|
|
| PTZ00419 |
PTZ00419 |
valyl-tRNA synthetase-like protein; Provisional |
9-431 |
4.40e-22 |
|
valyl-tRNA synthetase-like protein; Provisional
Pssm-ID: 240411 [Multi-domain] Cd Length: 995 Bit Score: 102.39 E-value: 4.40e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 9 IEKKWQEFWDNNKTYKVEED-PSIPKEKRLYILdmFPYPSANG-LHVGHPEGYTATDIFGRYKLLNGFHVLHPIGFDSFG 86
Cdd:PTZ00419 33 VESGWYEWWEKSGFFKPAEDaKSLNSGKKFVIV--LPPPNVTGyLHIGHALTGAIQDSLIRYHRMKGDETLWVPGTDHAG 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 87 LpaenyAIQTGTHPQKSTEENINKF----------------------KKQIKALGFAYDWDREIRTHEENYYKWTQWIFL 144
Cdd:PTZ00419 111 I-----ATQVVVEKKLMKEENKTRHdlgreeflkkvwewkdkhgnniCNQLRRLGSSLDWSREVFTMDEQRSKAVKEAFV 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 145 QLYKKGLAYVKEMPVWYCPELGTVLANEEiIQTSDGPKSERgsysvekkylrqwvLKITKYaerllddleelewpESVKE 224
Cdd:PTZ00419 186 RLYEDGLIYRDTRLVNWCCYLKTAISDIE-VEFEEIEKPTK--------------ITIPGY--------------DKKVE 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 225 MqrnwigkstGVEIEF--EIEGHSD-KIKVFTTRPDTIFGITYLVIAPENKliekitknnfkqnvlKYvKHeelksdlnr 301
Cdd:PTZ00419 237 V---------GVLWHFayPLEDSGQeEIVVATTRIETMLGDVAVAVHPKDE---------------RY-KK--------- 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 302 tslekdksgvFTGSYAFHP-ITNEKIPIWVGS-YVLGTYGTGAVMGVPAHDERDFQFAKKYQLKILPVisksgkneilek 379
Cdd:PTZ00419 283 ----------LHGKELIHPfIPDRKIPIIADDeLVDMEFGTGAVKITPAHDPNDYEIAKRHNLPFINI------------ 340
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 6919977 380 aFVDDG-ISINSpNEFNNLKNSEVKDKVIKWLTKNKKGKEKVAYKLRDWIFSR 431
Cdd:PTZ00419 341 -FTLDGkINENG-GEFAGMHRFDCRRKIEEELKEMGLLRDKVPNPMRLPRCSR 391
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
35-230 |
1.13e-21 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 99.80 E-value: 1.13e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 35 KRLYILDMFPYpsANG-LHVGHPEGYTATDIFGRYKLLNGFHVLHPIGFDSFGLPAENYAIQTGTHPQKSTEENINKFKK 113
Cdd:COG0143 1 KKFLVTTAIPY--ANGpPHIGHLYTYIPADILARYQRLRGHDVLFVTGTDEHGTKIELAAEKEGITPQELVDRIHAEFKE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 114 QIKALGFAYDwdREIRTHEENYYKWTQWIFLQLYKKGLAYVKEMPVWYCPE----------------------------- 164
Cdd:COG0143 79 LFEKLGISFD--NFIRTTSPEHKELVQEIFQRLYDNGDIYKGEYEGWYCPEcerflpdryvegtcpkcgaedaygdqcen 156
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6919977 165 LGTVLANEEIIQtsdgPKSER-GSySVEKKYLRQWVLKITKYAERLLDDLEEL-EWPESVKEMQRNWI 230
Cdd:COG0143 157 CGATLEPTELIN----PRSAIsGA-PPELREEEHYFFRLSKYQDRLLEWIEENpDIQPEVRNEVLSWL 219
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
44-227 |
1.79e-21 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 98.80 E-value: 1.79e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 44 PYPSANgLHVGHPEGYTATDIFGRYKLLNGFHVLHPIGFDSFGLPAENYAIQTGTHPQKSTEENINKFKKQIKALGFAYD 123
Cdd:PRK11893 10 YYPNGK-PHIGHAYTTLAADVLARFKRLRGYDVFFLTGTDEHGQKIQRKAEEAGISPQELADRNSAAFKRLWEALNISYD 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 124 wdREIRTHEENYYKWTQWIFLQLYKKGLAYVKEMPVWYCPELGTVLANEEIIQtsDGPKSERGSYSVEKKYLRQWVLKIT 203
Cdd:PRK11893 89 --DFIRTTDPRHKEAVQEIFQRLLANGDIYLGKYEGWYCVRCEEFYTESELIE--DGYRCPPTGAPVEWVEEESYFFRLS 164
|
170 180
....*....|....*....|....*...
gi 6919977 204 KYAERLLDDLEELEW---PESV-KEMQR 227
Cdd:PRK11893 165 KYQDKLLELYEANPDfiqPASRrNEVIS 192
|
|
| metG |
TIGR00398 |
methionine--tRNA ligase; The methionyl-tRNA synthetase (metG) is a class I amino acyl-tRNA ... |
44-231 |
6.04e-21 |
|
methionine--tRNA ligase; The methionyl-tRNA synthetase (metG) is a class I amino acyl-tRNA ligase. This model appears to recognize the methionyl-tRNA synthetase of every species, including eukaryotic cytosolic and mitochondrial forms. The UPGMA difference tree calculated after search and alignment according to this model shows an unusual deep split between two families of MetG. One family contains forms from the Archaea, yeast cytosol, spirochetes, and E. coli, among others. The other family includes forms from yeast mitochondrion, Synechocystis sp., Bacillus subtilis, the Mycoplasmas, Aquifex aeolicus, and Helicobacter pylori. The E. coli enzyme is homodimeric, although monomeric forms can be prepared that are fully active. Activity of this enzyme in bacteria includes aminoacylation of fMet-tRNA with Met; subsequent formylation of the Met to fMet is catalyzed by a separate enzyme. Note that the protein from Aquifex aeolicus is split into an alpha (large) and beta (small) subunit; this model does not include the C-terminal region corresponding to the beta chain. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273058 [Multi-domain] Cd Length: 530 Bit Score: 97.45 E-value: 6.04e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 44 PYPSANG-LHVGHPEGYTATDIFGRYKLLNGFHVLHPIGFDSFGLPAENYAIQTGTHPQKSTEENINKFKKQIKALGFAY 122
Cdd:TIGR00398 6 ALPYANGkPHLGHAYTTILADVYARYKRLRGYEVLFVCGTDEHGTKIELKAEQEGLTPKELVDKYHEEFKDDWKWLNISF 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 123 DwdREIRTHEENYYKWTQWIFLQLYKKGLAYVKEMPVWYCPELGTVLANEEII--------QTSDG-------------- 180
Cdd:TIGR00398 86 D--RFIRTTDEEHKEIVQKIFQKLKENGYIYEKEIKQLYCPECEMFLPDRYVEgtcpkcgsEDARGdhcevcgrhlepte 163
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 6919977 181 ---PKSERGSYSVEKKYLRQWVLKITKYAERLLD----DLEELEWPESVKEMQRNWIG 231
Cdd:TIGR00398 164 linPRCKICGAKPELRDSEHYFFRLSAFEKELEEwirkNPESGSPASNVKNKAQNWLK 221
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ... |
686-798 |
5.06e-17 |
|
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 78.60 E-value: 5.06e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 686 REIISELHKVIKKVTEDTEKLNFNTAISAMMIFINELLKyeKNYLNIFKP---------------------FIIILSPYA 744
Cdd:pfam08264 2 RWILSRLNKLIKEVTEAYENYRFNTAAQALYEFFWNDLS--DWYLELIKDrlygeepdsraqttlyevletLLRLLAPFM 79
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 6919977 745 PHLAEELWEYIgelpSLFKNSkWPKFDESLIIKGKKEI-----VLQINGKIKDKILLNK 798
Cdd:pfam08264 80 PFITEELWQKE----SIHLAP-WPEDAELEEAELEEAFelrqeIVQAIRKLRSELKIKK 133
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
46-230 |
1.34e-16 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 81.89 E-value: 1.34e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 46 PSANGL-HVGHPEGYTATDIFGRYKLLNGFHVLHPIGFDSFGLPAE-----NYAIQTGTHPQKSTEENINK--------- 110
Cdd:cd00818 10 PYANGLpHYGHALNKILKDIINRYKTMQGYYVPRRPGWDCHGLPIElkvekELGISGKKDIEKMGIAEFNAkcrefalry 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 111 ---FKKQIKALGFAYDWDREIRTHEENYYKWTQWIFLQLYKKGLAYVKEMPVWYcPelgtvlaneeIIQtsdgpksergs 187
Cdd:cd00818 90 vdeQEEQFQRLGVWVDWENPYKTMDPEYMESVWWVFKQLHEKGLLYRGYKVVPW-P----------LIY----------- 147
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 6919977 188 YSVEkkylrQWVLKITKYAERLLDDLEELEW-PESVKEMQRNWI 230
Cdd:cd00818 148 RATP-----QWFIRVTKIKDRLLEANDKVNWiPEWVKNRFGNWL 186
|
|
| PLN02381 |
PLN02381 |
valyl-tRNA synthetase |
1-412 |
1.97e-16 |
|
valyl-tRNA synthetase
Pssm-ID: 215214 [Multi-domain] Cd Length: 1066 Bit Score: 84.18 E-value: 1.97e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 1 MSK-YEFIKIEKKWQEFWDNNKTYKVEEDPSIPKekrlyILDMFPYPSANG-LHVGHPEGYTATDIFGRYKLLNGFHVLH 78
Cdd:PLN02381 96 MAKqYSPSAVEKSWYAWWEKSGYFGADAKSSKPP-----FVIVLPPPNVTGaLHIGHALTAAIEDTIIRWKRMSGYNALW 170
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 79 PIGFDSFGLPAENYAIQTGTHPQKSTEENINKFK-----------------KQIKALGFAYDWDREIRTHEENYYKWTQW 141
Cdd:PLN02381 171 VPGVDHAGIATQVVVEKKLMRERHLTRHDIGREEfvsevwkwkdeyggtilNQLRRLGASLDWSRECFTMDEQRSKAVTE 250
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 142 IFLQLYKKGLAYVKEMPV-WYCpELGTVLANEEIIQTSDGPKSergsysvekkylrqwVLKITKYAERLlddleelewpe 220
Cdd:PLN02381 251 AFVRLYKEGLIYRDIRLVnWDC-TLRTAISDVEVDYIDIKERT---------------LLKVPGYDKPV----------- 303
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 221 svkemqrnwigkSTGVEIEFE--IEGHSDKIKVFTTRPDTIFGITYLVIAPENKliekitknnfkqnvlKYvKHeelksd 298
Cdd:PLN02381 304 ------------EFGVLTSFAypLEGGLGEIVVATTRIETMLGDTAIAIHPDDE---------------RY-KH------ 349
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 299 lnrtslekdksgvFTGSYAFHPITNEKIPIWV-GSYVLGTYGTGAVMGVPAHDERDFQFAKKYQLKILPVisksgkneil 377
Cdd:PLN02381 350 -------------LHGKFAVHPFNGRKLPIICdAILVDPNFGTGAVKITPAHDPNDFEVGKRHNLEFINI---------- 406
|
410 420 430
....*....|....*....|....*....|....*.
gi 6919977 378 ekaFVDDG-ISINSPNEFNNLKNSEVKDKVIKWLTK 412
Cdd:PLN02381 407 ---FTDDGkINSNGGSEFAGMPRFAAREAVIEALQK 439
|
|
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
4-722 |
2.21e-16 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 84.01 E-value: 2.21e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 4 YEFIKIEKKWQEFWDNNKTYkvEEDPSIPKEKRLYILDMFPyPSANGL-HVGHPEGYTATDIFGRYKLLNGFHVLHPIGF 82
Cdd:PLN02882 8 FSFPKQEEKILSLWSEIDAF--KTQLKRTEGLPEYIFYDGP-PFATGLpHYGHILAGTIKDIVTRYQSMTGHHVTRRFGW 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 83 DSFGLPAEnYAIQTG---THPQKSTEENINKFKKQIKALGFAY--DWDREI-RTHE----ENYYK----------WtqWI 142
Cdd:PLN02882 85 DCHGLPVE-YEIDKKlgiKRRDDVLKMGIDKYNEECRSIVTRYskEWEKTVtRTGRwidfENDYKtmdpkfmesvW--WV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 143 FLQLYKKGLAY--VKEMPvwYCPELGTVLANEEiiqtsdgpksergsysVEKKYlrqwvlkitkyaeRLLDDLEelewpe 220
Cdd:PLN02882 162 FKQLFEKGLVYkgFKVMP--YSTACKTPLSNFE----------------AGLNY-------------KDVSDPA------ 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 221 svkemqrnwigkstgVEIEFEIEGHSDKIKV--FTTRPDTIFGITYLVIAPENKLIEKITKNNFKQNVLKYVKHEELKSD 298
Cdd:PLN02882 205 ---------------VMVSFPIVGDPDNASFvaWTTTPWTLPSNLALCVNPNFTYVKVRNKYTGKVYIVAESRLSALPTA 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 299 LNRtSLEKDKSGVFTGSYA---------------------FHPITNEKIPIWVGSYVLGTYGTGAVMGVPAHDERDF--- 354
Cdd:PLN02882 270 KPK-SKKGSKPENAAEGYEvlakvpgsslvgkkyeplfdyFSEFSDTAFRVVADDYVTDDSGTGVVHCAPAFGEDDYrvc 348
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 355 ---QFAKKYQLKILPVIS----------------KSGKNEILE--KA---FVDDGISINS----------------PNEF 394
Cdd:PLN02882 349 lanGIIEKGGNLPVPVDDdgcftekvtdfsgryvKDADKDIIAaiKAkgrLVKSGSITHSypfcwrsdtpliyravPSWF 428
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 395 nnLKNSEVKDKVIKwltKNKKG-------KEKVAYK----LRDWIFSRQRYWGEPIPILFDKLGNAIPLEenDLPLKLPE 463
Cdd:PLN02882 429 --VKVEEIKDRLLE---NNKQTywvpdyvKEKRFHNwlenARDWAVSRSRFWGTPLPIWISDDGEEVVVI--GSIAELEK 501
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 464 IANYK--------------PS--GTGESPLSRIKDwvnVKDMGFtrETNTMPqwagscWYYLRYldpknskEFANKKKIE 527
Cdd:PLN02882 502 LSGVKvtdlhrhfidhitiPSsrGPEFGVLRRVDD---VFDCWF--ESGSMP------YAYIHY-------PFENKELFE 563
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 528 YWMPVDLYIGGAEHTvlhllysRFWhkvLYDLGYVNT----KEPFKKLINQGIitsfsyqkengvlipndqVIEKDNKff 603
Cdd:PLN02882 564 KNFPADFVAEGLDQT-------RGW---FYTLMVLSTalfdKPAFKNLICNGL------------------VLAEDGK-- 613
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 604 dkkdnkevtqviaKMSKSLKNVINPDDIIKEFGADSMRIYeMFMGPLTDSKPWNTK--GIIGV-----------FRFL-N 669
Cdd:PLN02882 614 -------------KMSKSLKNYPDPNEVIDKYGADALRLY-LINSPVVRAEPLRFKeeGVFGVvkdvflpwynaYRFLvQ 679
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6919977 670 KIWNLREKELSKENP-------------PREIISELHKVIKKVTEDTEKLNFNTAISAMMIFINEL 722
Cdd:PLN02882 680 NAKRLEVEGGAPFVPldlaklqnsanvlDRWINSATQSLVKFVREEMGAYRLYTVVPYLVKFIDNL 745
|
|
| PTZ00427 |
PTZ00427 |
isoleucine-tRNA ligase, putative; Provisional |
10-643 |
3.37e-12 |
|
isoleucine-tRNA ligase, putative; Provisional
Pssm-ID: 173617 [Multi-domain] Cd Length: 1205 Bit Score: 70.38 E-value: 3.37e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 10 EKKWQEFWDNNKTYKVEEDpsIPKEKRLYILDMFPyPSANGL-HVGHPEGYTATDIFGRYKLLNGFHVLHPIGFDSFGLP 88
Cdd:PTZ00427 78 EEKVLKYWKSIDAFNTSNK--LAKNKKAYIFYDGP-PFATGLpHYGHLLAGIIKDCVTRYFYQCGFSVERKFGWDCHGLP 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 89 AEnYAIQTGTHPQKstEENI--------------------NKFKKQIKALGFAYDWDREIRTHEENYYKWTQWIFLQLYK 148
Cdd:PTZ00427 155 IE-YEIEKENNINK--KEDIlkmgidvynekcrgivlkysNEWVKTVERIGRWIDFKNDYKTMDKTFMESVWWVFSELYK 231
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 149 KGLAY--VKEMPvwYCPELGTVLANEEI----------------IQTSDGPKSERgSYSVEkkylrqwvlkitkyaerll 210
Cdd:PTZ00427 232 NNYVYksFKVMP--YSCKCNTPISNFELnlnykdtpdpsiiisfVLCSDFPKVEE-ECNIE------------------- 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 211 DDLEELEWPESV--KEMQRNWIGKSTGVEIEFEIEGHSDkIKVFTTRPDTIFG---------ITYL----------VIAP 269
Cdd:PTZ00427 290 EDKQLLGEKYSVlyNNKRENSNNGNNNSTNNVCYAQHSE-ILAWTTTPWTLPSnlalcvnehFTYLrihhvksnrvVIVG 368
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 270 ENKLiEKITK------------NNFKQNVLKYVKHEELksdlnrtslekdksgvFTGSYAFHPITNEKIPIWVGSYVLGT 337
Cdd:PTZ00427 369 ECRL-EWIMKelkwnvedlkivNRFKGKELKGLRYKPL----------------FTNFYEKYNFKERAYKILADDFVTDD 431
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 338 YGTGAVMGVPAHDERDFQFAKKYQLkILPvisksgkneilEKAFVDDGISINS--PNEFNNLKNSEVK--DKVIK----- 408
Cdd:PTZ00427 432 AGTGIVHCAPTYGEDDFRVCKKNGV-IDP-----------EKNIFIDPLDANGyfTNEVEEVQNLYIKeaDNVIKkklkn 499
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 409 -------------------------------W----------LTKNKKG--------KEKVAYK----LRDWIFSRQRYW 435
Cdd:PTZ00427 500 enrllsnntivhsypfcwrsdtpliyraipaWfirvsnstneLVKNNETtywipahiKEKKFHNwikdAKDWCISRNRYW 579
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 436 GEPIPILFD-KLGNAIPLEENDLPLKLPEIANYK--------------PSGTGESPLSRIKDwvnVKDMGFtrETNTMPq 500
Cdd:PTZ00427 580 GTPIPIWADeKMETVICVESIKHLEELSGVKNINdlhrhfidhieiknPKGKTYPKLKRIPE---VFDCWF--ESGSMP- 653
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 501 wagscwyYLRYLDPkNSKEFANKKKIeywMPVDLYIGGAEHTvlhllysRFWhkvLYDLGYVNT----KEPFKKLINQGI 576
Cdd:PTZ00427 654 -------YAKVHYP-FSTEKEDFHKI---FPADFIAEGLDQT-------RGW---FYTLLVISTllfdKAPFKNLICNGL 712
|
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6919977 577 itsfsyqkengvlipndqVIEKDNKffdkkdnkevtqviaKMSKSLKNVINPDDIIKEFGADSMRIY 643
Cdd:PTZ00427 713 ------------------VLASDGK---------------KMSKRLKNYPDPLYILDKYGADSLRLY 746
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
424-643 |
7.97e-12 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 67.64 E-value: 7.97e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 424 LRDWIFSRQRYWGEPIPILFDKlgnaipleendlplklpeianykpsgTGESPLSRikdwvnvkdmgftRETNTMPQW-- 501
Cdd:cd00818 189 RRDWCISRQRYWGTPIPVWYCE--------------------------DCGEVLVR-------------RVPDVLDVWfd 229
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 502 AGSCWYYLryldpkNSKEFANKKKIEYWmPVDLYIGGAEHTvlhllysRFWHKVLYDLG-YVNTKEPFKKLINQGIITSf 580
Cdd:cd00818 230 SGSMPYAQ------LHYPFENEDFEELF-PADFILEGSDQT-------RGWFYSLLLLStALFGKAPYKNVIVHGFVLD- 294
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6919977 581 syqkENGvlipndqviekdnkffdkkdnkevtqviAKMSKSLKNVINPDDIIKEFGADSMRIY 643
Cdd:cd00818 295 ----EDG----------------------------RKMSKSLGNYVDPQEVVDKYGADALRLW 325
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
44-170 |
8.60e-12 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 68.64 E-value: 8.60e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 44 PYpsANG-LHVGHPEGYTATDIFGRYKLLNGFHVLHPIGFDSFGLPAENYAIQTGTHPqkstEENINKFKKQIKA--LGF 120
Cdd:PRK00133 11 PY--ANGpIHLGHLVEYIQADIWVRYQRMRGHEVLFVCADDAHGTPIMLKAEKEGITP----EELIARYHAEHKRdfAGF 84
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 6919977 121 AYDWDREIRTHEENYYKWTQWIFLQLYKKGLAYVKEMPVWYCPELGTVLA 170
Cdd:PRK00133 85 GISFDNYGSTHSEENRELAQEIYLKLKENGYIYEKTIEQLYDPEKGMFLP 134
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
616-756 |
1.65e-10 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 64.36 E-value: 1.65e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 616 AKMSKSLKNVINPDDIIKEFGADSMRIYEMFMGPLTDSKPWNTK-----------GIIG-----VFRFLNKIWNLREKEL 679
Cdd:COG0143 326 EKMSKSRGNVIDPDDLLDRYGPDALRYYLLREVPFGQDGDFSWEdfvarvnsdlaNDLGnlasrTLSMIHKYFDGKVPEP 405
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 680 SKENPP-REIISELHKVIKKVTEDTEKLNFNTAISAMMIFINELLKY--EK-------------------NYLNIFKPFI 737
Cdd:COG0143 406 GELTEAdEELLAEAEAALEEVAEAMEAFEFRKALEEIMALARAANKYidETapwklakdedperlatvlyTLLEALRILA 485
|
170
....*....|....*....
gi 6919977 738 IILSPYAPHLAEELWEYIG 756
Cdd:COG0143 486 ILLKPFLPETAEKILEQLG 504
|
|
| Anticodon_Ia_Val |
cd07962 |
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA ... |
666-755 |
1.04e-09 |
|
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.
Pssm-ID: 153416 [Multi-domain] Cd Length: 135 Bit Score: 57.18 E-value: 1.04e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 666 RFLNKIWN--------LREKELSKENPP------REIISELHKVIKKVTEDTEKLNFNTAISAMMIFIN--------ELL 723
Cdd:cd07962 11 NFCNKLWNaarfvlmnLEDDDEPEEDPEslsladRWILSRLNKTVEEVTEALENYRFSEAATALYEFFWndfcdwylELV 90
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 6919977 724 KYE------------KNYLN-IFKPFIIILSPYAPHLAEELWEYI 755
Cdd:cd07962 91 KPRlygedeeekkaaRATLYyVLETILRLLHPFMPFITEELWQRL 135
|
|
| Anticodon_Ia_Ile_ABEc |
cd07961 |
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA ... |
659-775 |
3.39e-08 |
|
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153415 [Multi-domain] Cd Length: 183 Bit Score: 54.09 E-value: 3.39e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 659 KGIIGVFR-FLNKIWN----------LREKELSKENPPRE--------IISELHKVIKKVTEDTEKLNFNTAISAMMIFI 719
Cdd:cd07961 4 KGVREVVRkVLLPLWNayrffvtyanLDGFDPGKDDDAVAslnvldrwILSRLNSLIKEVTEEMEAYDLYTAVRALLEFI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 720 NELLKYeknYL------------------------NIFKPFIIILSPYAPHLAEELW-EYIGELPSLfKNS----KWPKF 770
Cdd:cd07961 84 DELTNW---YIrrnrkrfwgeegdddklaayatlyEVLLTLSRLMAPFTPFITEEIYqNLRRELGDA-PESvhllDWPEV 159
|
....*
gi 6919977 771 DESLI 775
Cdd:cd07961 160 DESLI 164
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
617-782 |
3.49e-08 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 56.81 E-value: 3.49e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 617 KMSKSLKNVINPDDIIKEFGADSMRIY---EMfmgPLTDSKPWNTKGIIGVFR--FLNKIWNL---------------RE 676
Cdd:PRK11893 299 KMSKSLGNVIDPFDLVDEYGVDAVRYFllrEI---PFGQDGDFSREAFINRINadLANDLGNLaqrtlsmiaknfdgkVP 375
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 677 KELSKENPPREIISELHKVIKKVTEDTEKLNFNTAISAMMIFINELLKyeknYLNIFKP--------------------- 735
Cdd:PRK11893 376 EPGALTEADEALLEAAAALLERVRAAMDNLAFDKALEAILALVRAANK----YIDEQAPwslaktdperlatvlytllev 451
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 6919977 736 ---FIIILSPYAPHLAEELWEYIGELPSL---FKNSKWPKFDESLIIKGKKEI 782
Cdd:PRK11893 452 lrgIAVLLQPVMPELAAKILDQLGVEEDEnrdFAALSWGRLAPGTTLPKPEPI 504
|
|
| PLN02959 |
PLN02959 |
aminoacyl-tRNA ligase |
7-88 |
1.48e-07 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215518 [Multi-domain] Cd Length: 1084 Bit Score: 55.46 E-value: 1.48e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 7 IKIEKKWQEFWDNNKTYKVE--EDPSIPKEKrlyILDMFPYPSANG-LHVGHPEGYTATDIFGRYKLLNGFHVLHPIGFD 83
Cdd:PLN02959 16 LEIEVAVQKWWEEEKVFEAEagDEPPKPGEK---FFGNFPYPYMNGlLHLGHAFSLSKLEFAAAYHRLRGANVLLPFAFH 92
|
....*
gi 6919977 84 SFGLP 88
Cdd:PLN02959 93 CTGMP 97
|
|
| Anticodon_Ia_Ile_BEm |
cd07960 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; ... |
688-795 |
6.17e-07 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial and eukaryotic mitochondrial members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153414 [Multi-domain] Cd Length: 180 Bit Score: 50.22 E-value: 6.17e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 688 IISELHKVIKKVTEDTEKLNFNTAISAMMIFINELL--------K-----YEKNYLN----------IFKPFIIILSPYA 744
Cdd:cd07960 49 ALHRLNELIKEVREAYENYEFHKVYQALNNFCTVDLsafyldiiKdrlycDAKDSLErrsaqtvlyhILDALLKLLAPIL 128
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 6919977 745 PHLAEELWEYIGELP---SLFKnSKWPKFDESLIIKGKKEIVLQINgKIKDKIL 795
Cdd:cd07960 129 PFTAEEVWEHLPGEKkeeSVFL-EDWPELPEEWKDEELEEKWEKLL-ALRDEVN 180
|
|
| Anticodon_Ia_Leu_AEc |
cd07959 |
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This ... |
656-753 |
8.71e-07 |
|
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153413 [Multi-domain] Cd Length: 117 Bit Score: 48.36 E-value: 8.71e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 656 WNTKGIIGVFRFLNKIWNL------REKELSKENPP-REIISELHKVIKKVTEDTEKLNFNTAI-SAMMIFINELLKYE- 726
Cdd:cd07959 1 FREEEANSAILRLERFYELaeelieTEGELEELTFIdRWLLSRLNRLIKETTEAYENMQFREALkEGLYELQNDLDWYRe 80
|
90 100 110
....*....|....*....|....*....|....*...
gi 6919977 727 -----------KNYLNIFkpfIIILSPYAPHLAEELWE 753
Cdd:cd07959 81 rggagmnkdllRRFIEVW---TRLLAPFAPHLAEEIWH 115
|
|
| Anticodon_Ia_like |
cd07375 |
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This ... |
659-725 |
2.62e-06 |
|
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This domain is found in a variety of class Ia aminoacyl tRNA synthetases, C-terminal to the catalytic core domain. It recognizes and specifically binds to the anticodon of the tRNA. Aminoacyl tRNA synthetases catalyze the transfer of cognate amino acids to the 3'-end of their tRNAs by specifically recognizing cognate from non-cognate amino acids. Members include valyl-, leucyl-, isoleucyl-, cysteinyl-, arginyl-, and methionyl-tRNA synthethases. This superfamily also includes a domain from MshC, an enzyme in the mycothiol biosynthetic pathway.
Pssm-ID: 153408 [Multi-domain] Cd Length: 117 Bit Score: 47.12 E-value: 2.62e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 659 KGIIGVFRFLNKIWNLR-------------EKELSKENPPREIISELHKVIKKVTEDTEKLNFNTAISAMMIFINELLKY 725
Cdd:cd07375 2 ERLKQARAFLNRLYRLLsffrkalggtqpkWDNELLEEADRELLARLQEFIKRTTNALEALDPTTAVQELFKFTNELNWY 81
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
617-807 |
1.21e-05 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 49.03 E-value: 1.21e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 617 KMSKSLKNVINPDDIIKEFGADSMRIY---EMFMGplTDSkPWNTKGIIGVFRF---------LNKIWNLREK----ELS 680
Cdd:PRK12267 299 KMSKSKGNVVDPEELVDRYGLDALRYYllrEVPFG--SDG-DFSPEALVERINSdlandlgnlLNRTVAMINKyfdgEIP 375
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 681 KENPP----REIISELHKVIKKVTEDTEKLNFNTAISAMMIFINELLKY-------------EK---------NYLNIFK 734
Cdd:PRK12267 376 APGNVtefdEELIALAEETLKNYEELMEELQFSRALEEVWKLISRANKYidetapwvlakdeGKkerlatvmyHLAESLR 455
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 735 PFIIILSPYAPHLAEELWEYIG---ELPSLFKNSKWPKFDESLIIKG----------KKEIVLQINGKIKDKILLNKETG 801
Cdd:PRK12267 456 KVAVLLSPFMPETSKKIFEQLGleeELTSWESLLEWGGLPAGTKVAKgeplfpridvEEEIAYIKEQMEGSAPKEPEEKE 535
|
....*.
gi 6919977 802 EKELKE 807
Cdd:PRK12267 536 KKPEKP 541
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
617-652 |
1.29e-05 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 47.91 E-value: 1.29e-05
10 20 30
....*....|....*....|....*....|....*.
gi 6919977 617 KMSKSLKNVINPDDIIKEFGADSMRIYEMFMGPLTD 652
Cdd:cd00814 280 KMSKSRGNVVDPDDLLERYGADALRYYLLRERPEGK 315
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
616-769 |
1.70e-05 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 48.61 E-value: 1.70e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 616 AKMSKSLKNVINPDDIIKEFGADSMRIYEMFMGPLTDSK---PW-------NTK--GIIG-----VFRFLNKIWnlrEKE 678
Cdd:PRK00133 328 AKMSKSRGTFIWARTYLDHLDPDYLRYYLAAKLPETIDDldfNWedfqqrvNSElvGKVVnfasrTAGFINKRF---DGK 404
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 679 LSKENPPREIISELHKVIKKVTEDTEKLNFNTAISAMM---IFINELLKYEK-----------------NYLNIFKPFII 738
Cdd:PRK00133 405 LPDALADPELLEEFEAAAEKIAEAYEAREFRKALREIMalaDFANKYVDDNEpwklakqdgerlqavcsVGLNLFRALAI 484
|
170 180 190
....*....|....*....|....*....|.
gi 6919977 739 ILSPYAPHLAEELWEYIGELPSLFKNSKWPK 769
Cdd:PRK00133 485 YLKPVLPELAERAEAFLNLEELTWDDAQQPL 515
|
|
| PRK05347 |
PRK05347 |
glutaminyl-tRNA synthetase; Provisional |
43-154 |
5.17e-04 |
|
glutaminyl-tRNA synthetase; Provisional
Pssm-ID: 235424 [Multi-domain] Cd Length: 554 Bit Score: 43.55 E-value: 5.17e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 43 FPyPSANG-LHVGHpegytATDIFgryklLNgfhvlhpigfdsFGLpAENYAIQTG-----THPQKSTEENINKFKKQIK 116
Cdd:PRK05347 34 FP-PEPNGyLHIGH-----AKSIC-----LN------------FGL-AQDYGGKCNlrfddTNPEKEDQEYVDSIKEDVR 89
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 6919977 117 ALGFayDWDREIRtHEENYykwtqwiFLQLY-------KKGLAYV 154
Cdd:PRK05347 90 WLGF--DWSGELR-YASDY-------FDQLYeyaveliKKGKAYV 124
|
|
| PLN02610 |
PLN02610 |
probable methionyl-tRNA synthetase |
31-177 |
9.64e-04 |
|
probable methionyl-tRNA synthetase
Pssm-ID: 215329 [Multi-domain] Cd Length: 801 Bit Score: 42.84 E-value: 9.64e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 31 IPKEKRLYILDMFPYPSaNGLHVGHPEGYT-ATDIFGRYKLLNGFHVLHPIGFDSFGLPAENYAIQTGTHPQKSTEEnIN 109
Cdd:PLN02610 13 IPGKRNILITSALPYVN-NVPHLGNIIGCVlSADVFARYCRLRGYNAIYICGTDEYGTATETKALEENCTPKEICDK-YH 90
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6919977 110 KFKKQIkalgfaYDW-----DREIRTHEENYYKWTQWIFLQLYKKGLAYVKEMPVWYCPELGTVLANEEIIQT 177
Cdd:PLN02610 91 AIHKEV------YDWfdisfDKFGRTSTPQQTEICQAIFKKLMENNWLSENTMQQLYCDTCQKFLADRLVEGT 157
|
|
| CysS |
COG0215 |
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ... |
617-725 |
3.11e-03 |
|
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439985 [Multi-domain] Cd Length: 465 Bit Score: 40.86 E-value: 3.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 617 KMSKSLKNVINPDDIIKEFGADSMRiyeMFMG------PLTdskpWNTKGIIGVFRFLNKIWNLREKELSKENPPREIIS 690
Cdd:COG0215 265 KMSKSLGNFFTVRDLLKKYDPEVLR---FFLLsahyrsPLD----FSEEALEEAEKALERLYNALRRLEEALGAADSSAE 337
|
90 100 110
....*....|....*....|....*....|....*....
gi 6919977 691 ELHKVIKKVtedTEKLN--FNT--AISAMMIFINELLKY 725
Cdd:COG0215 338 EIEELREEF---IAAMDddFNTpeALAVLFELVREINKA 373
|
|
| Anticodon_Ia_Met |
cd07957 |
Anticodon-binding domain of methionyl tRNA synthetases; This domain is found in methionyl tRNA ... |
667-753 |
4.32e-03 |
|
Anticodon-binding domain of methionyl tRNA synthetases; This domain is found in methionyl tRNA synthetases (MetRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon (CAU). MetRS catalyzes the transfer of methionine to the 3'-end of its tRNA.
Pssm-ID: 153411 [Multi-domain] Cd Length: 129 Bit Score: 38.24 E-value: 4.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6919977 667 FLNKIWNLREKELSKENPP--------REIISELHKVIKKVTEDTEKLNFNTAISAMM-------IFINE-----LLKYE 726
Cdd:cd07957 12 LVNRTLNMASKYFGGVVPEfgglteedEELLEEAEELLEEVAEAMEELEFRKALEEIMelaraanKYIDEtapwkLAKEE 91
|
90 100 110
....*....|....*....|....*....|....*.
gi 6919977 727 K---------NYLNIFKPFIIILSPYAPHLAEELWE 753
Cdd:cd07957 92 DperlatvlyVLLELLRILAILLSPFMPETAEKILD 127
|
|
| |
