NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|223590219|sp|O42370|]
View 

RecName: Full=Homeobox protein Hox-D3a; Short=Hox-D3

Protein Classification

homeobox domain-containing protein( domain architecture ID 13432700)

homeobox domain-containing protein may be involved in the transcriptional regulation of key eukaryotic developmental processes

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
162-218 9.03e-29

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 106.43  E-value: 9.03e-29
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 223590219  162 KRVRTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYKK 218
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
DUF4074 pfam13293
Domain of unknown function (DUF4074); This family is found at the C-terminal of Homeobox ...
 333-394 2.68e-27

Domain of unknown function (DUF4074); This family is found at the C-terminal of Homeobox proteins in Metazoa.


:

Pssm-ID: 463833  Cd Length: 63  Bit Score: 103.01  E-value: 2.68e-27
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 223590219  333 ASGP-MFNLGHLPHPSSASVDYSCAAQIPGNHHHGPCDPHPTYTDLSSHHASQGRLQDAPKLT 394
Cdd:pfam13293   1 GSGPsVFGLNHLPHPSSASMDYSGAAQMPPSQHHGPCDPHPTYTDLSSHHPSQGRIQEAPKLT 63
COG5576 super family cl35021
Homeodomain-containing transcription factor [Transcription];
116-237 2.30e-13

Homeodomain-containing transcription factor [Transcription];


The actual alignment was detected with superfamily member COG5576:

Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 67.46  E-value: 2.30e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223590219 116 STATPVISKQIFPWMKETRQNA-KQKSTNCPAAGEtcDDKSPPGPaSKRVRTayTSAQLVELEKEFHFNRYLCRPRRVEM 194
Cdd:COG5576   10 SALESQRMPQIRTIKTTKNKREvEAADSEMKLERK--QDGSSPPK-SKRRRT--TDEQLMVLEREFEINPYPSSITRIKL 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 223590219 195 ANLLNLTERQIKIWFQNRRMKYKKdQKSKGIMHSPLGHSPDRS 237
Cdd:COG5576   85 SLLLNMPPKSVQIWFQNKRAKEKK-KRSGKVEQRPGEEEADLA 126
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
162-218 9.03e-29

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 106.43  E-value: 9.03e-29
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 223590219  162 KRVRTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYKK 218
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
DUF4074 pfam13293
Domain of unknown function (DUF4074); This family is found at the C-terminal of Homeobox ...
 333-394 2.68e-27

Domain of unknown function (DUF4074); This family is found at the C-terminal of Homeobox proteins in Metazoa.


Pssm-ID: 463833  Cd Length: 63  Bit Score: 103.01  E-value: 2.68e-27
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 223590219  333 ASGP-MFNLGHLPHPSSASVDYSCAAQIPGNHHHGPCDPHPTYTDLSSHHASQGRLQDAPKLT 394
Cdd:pfam13293   1 GSGPsVFGLNHLPHPSSASMDYSGAAQMPPSQHHGPCDPHPTYTDLSSHHPSQGRIQEAPKLT 63
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 161-217 5.59e-26

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 98.86  E-value: 5.59e-26
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 223590219   161 SKRVRTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYK 217
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 162-220 5.42e-25

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 96.54  E-value: 5.42e-25
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 223590219 162 KRVRTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYKKDQ 220
Cdd:cd00086    1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
116-237 2.30e-13

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 67.46  E-value: 2.30e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223590219 116 STATPVISKQIFPWMKETRQNA-KQKSTNCPAAGEtcDDKSPPGPaSKRVRTayTSAQLVELEKEFHFNRYLCRPRRVEM 194
Cdd:COG5576   10 SALESQRMPQIRTIKTTKNKREvEAADSEMKLERK--QDGSSPPK-SKRRRT--TDEQLMVLEREFEINPYPSSITRIKL 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 223590219 195 ANLLNLTERQIKIWFQNRRMKYKKdQKSKGIMHSPLGHSPDRS 237
Cdd:COG5576   85 SLLLNMPPKSVQIWFQNKRAKEKK-KRSGKVEQRPGEEEADLA 126
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
162-218 9.03e-29

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 106.43  E-value: 9.03e-29
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 223590219  162 KRVRTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYKK 218
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
DUF4074 pfam13293
Domain of unknown function (DUF4074); This family is found at the C-terminal of Homeobox ...
 333-394 2.68e-27

Domain of unknown function (DUF4074); This family is found at the C-terminal of Homeobox proteins in Metazoa.


Pssm-ID: 463833  Cd Length: 63  Bit Score: 103.01  E-value: 2.68e-27
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 223590219  333 ASGP-MFNLGHLPHPSSASVDYSCAAQIPGNHHHGPCDPHPTYTDLSSHHASQGRLQDAPKLT 394
Cdd:pfam13293   1 GSGPsVFGLNHLPHPSSASMDYSGAAQMPPSQHHGPCDPHPTYTDLSSHHPSQGRIQEAPKLT 63
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 161-217 5.59e-26

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 98.86  E-value: 5.59e-26
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 223590219   161 SKRVRTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYK 217
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 162-220 5.42e-25

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 96.54  E-value: 5.42e-25
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 223590219 162 KRVRTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYKKDQ 220
Cdd:cd00086    1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
116-237 2.30e-13

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 67.46  E-value: 2.30e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223590219 116 STATPVISKQIFPWMKETRQNA-KQKSTNCPAAGEtcDDKSPPGPaSKRVRTayTSAQLVELEKEFHFNRYLCRPRRVEM 194
Cdd:COG5576   10 SALESQRMPQIRTIKTTKNKREvEAADSEMKLERK--QDGSSPPK-SKRRRT--TDEQLMVLEREFEINPYPSSITRIKL 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 223590219 195 ANLLNLTERQIKIWFQNRRMKYKKdQKSKGIMHSPLGHSPDRS 237
Cdd:COG5576   85 SLLLNMPPKSVQIWFQNKRAKEKK-KRSGKVEQRPGEEEADLA 126
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH