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Conserved domains on  [gi|47550831|ref|NP_999877|]
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AH receptor-interacting protein [Danio rerio]

Protein Classification

FKBP-type peptidyl-prolyl cis-trans isomerase( domain architecture ID 10446594)

FKBP-type peptidyl-prolyl cis-trans isomerase acts as a PPIase that accelerates the folding of proteins

CATH:  3.10.50.40
EC:  5.2.1.8
Gene Ontology:  GO:0003755|GO:0000413|GO:0061077
PubMed:  27664121
SCOP:  4001062

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
FKBP_C pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase;
30-91 5.19e-13

FKBP-type peptidyl-prolyl cis-trans isomerase;


:

Pssm-ID: 459735  Cd Length: 94  Bit Score: 64.14  E-value: 5.19e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 47550831    30 NGTKVKFHYRTSLCDGTLLDDSRTMGghsKPMELILGKKFKLPVWEQVVTTMKEGEIAEFTC 91
Cdd:pfam00254   7 KGDRVTVHYTGTLEDGTVFDSSYDRG---KPFEFTLGSGQVIPGWDEGLVGMKVGEKRKLTI 65
Spy super family cl27809
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 187-310 3.45e-05

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member COG3914:

Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 45.37  E-value: 3.45e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550831 187 GNALFKSGDISGAAEKYYNAIAClkslqmkeRPGDehwikldlmiTPLLLNYCQCKLLLGQYYEVLDHCSSIINKYEDNV 266
Cdd:COG3914 119 GNLLLALGRLEEALAALRRALAL--------NPDF----------AEAYLNLGEALRRLGRLEEAIAALRRALELDPDNA 180

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 47550831 267 KAYFKRGKAHAAVWNEAEARADFAKVLTLDPSLEASIAKELRAM 310
Cdd:COG3914 181 EALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNLLFAL 224
 
Name Accession Description Interval E-value
FKBP_C pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase;
30-91 5.19e-13

FKBP-type peptidyl-prolyl cis-trans isomerase;


Pssm-ID: 459735  Cd Length: 94  Bit Score: 64.14  E-value: 5.19e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 47550831    30 NGTKVKFHYRTSLCDGTLLDDSRTMGghsKPMELILGKKFKLPVWEQVVTTMKEGEIAEFTC 91
Cdd:pfam00254   7 KGDRVTVHYTGTLEDGTVFDSSYDRG---KPFEFTLGSGQVIPGWDEGLVGMKVGEKRKLTI 65
FkpA COG0545
FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein ...
 13-91 2.23e-08

FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440311 [Multi-domain]  Cd Length: 104  Bit Score: 51.34  E-value: 2.23e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 47550831  13 IQKKVISPGKGElsTFPNGTKVKFHYRTSLCDGTLLDDSRTMGghsKPMELILGKKFKLPVWEQVVTTMKEGEIAEFTC 91
Cdd:COG0545   1 LQYKVLKEGTGA--KPKAGDTVTVHYTGTLLDGTVFDSSYDRG---EPATFPLGVGQVIPGWDEGLQGMKVGGKRRLVI 74
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 187-310 3.45e-05

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 45.37  E-value: 3.45e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550831 187 GNALFKSGDISGAAEKYYNAIAClkslqmkeRPGDehwikldlmiTPLLLNYCQCKLLLGQYYEVLDHCSSIINKYEDNV 266
Cdd:COG3914 119 GNLLLALGRLEEALAALRRALAL--------NPDF----------AEAYLNLGEALRRLGRLEEAIAALRRALELDPDNA 180

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 47550831 267 KAYFKRGKAHAAVWNEAEARADFAKVLTLDPSLEASIAKELRAM 310
Cdd:COG3914 181 EALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNLLFAL 224
 
Name Accession Description Interval E-value
FKBP_C pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase;
30-91 5.19e-13

FKBP-type peptidyl-prolyl cis-trans isomerase;


Pssm-ID: 459735  Cd Length: 94  Bit Score: 64.14  E-value: 5.19e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 47550831    30 NGTKVKFHYRTSLCDGTLLDDSRTMGghsKPMELILGKKFKLPVWEQVVTTMKEGEIAEFTC 91
Cdd:pfam00254   7 KGDRVTVHYTGTLEDGTVFDSSYDRG---KPFEFTLGSGQVIPGWDEGLVGMKVGEKRKLTI 65
FkpA COG0545
FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein ...
 13-91 2.23e-08

FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440311 [Multi-domain]  Cd Length: 104  Bit Score: 51.34  E-value: 2.23e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 47550831  13 IQKKVISPGKGElsTFPNGTKVKFHYRTSLCDGTLLDDSRTMGghsKPMELILGKKFKLPVWEQVVTTMKEGEIAEFTC 91
Cdd:COG0545   1 LQYKVLKEGTGA--KPKAGDTVTVHYTGTLLDGTVFDSSYDRG---EPATFPLGVGQVIPGWDEGLQGMKVGGKRRLVI 74
SlpA COG1047
Peptidyl-prolyl cis-trans isomerase, FKBP type [Posttranslational modification, protein ...
 30-90 2.99e-05

Peptidyl-prolyl cis-trans isomerase, FKBP type [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440668 [Multi-domain]  Cd Length: 138  Bit Score: 43.17  E-value: 2.99e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 47550831  30 NGTKVKFHYRTSLCDGTLLDDSRtmggHSKPMELILGKKFKLPVWEQVVTTMKEGEIAEFT 90
Cdd:COG1047   3 KGDVVTLHYTLKLEDGEVFDSTF----EGEPLEFLHGAGQLIPGLEEALEGMEVGDKKTVT 59
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 187-310 3.45e-05

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 45.37  E-value: 3.45e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550831 187 GNALFKSGDISGAAEKYYNAIAClkslqmkeRPGDehwikldlmiTPLLLNYCQCKLLLGQYYEVLDHCSSIINKYEDNV 266
Cdd:COG3914 119 GNLLLALGRLEEALAALRRALAL--------NPDF----------AEAYLNLGEALRRLGRLEEAIAALRRALELDPDNA 180

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 47550831 267 KAYFKRGKAHAAVWNEAEARADFAKVLTLDPSLEASIAKELRAM 310
Cdd:COG3914 181 EALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNLLFAL 224
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
185-298 7.70e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 40.38  E-value: 7.70e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550831 185 EEGNALFKSGDISGAAEKYYNAIACLkslqmkerpgdEHWIKLDLMITPLLLNYCQCKLLLGQYYEVLDHCSSIINKYED 264
Cdd:COG0457   6 DDAEAYNNLGLAYRRLGRYEEAIEDY-----------EKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPD 74

                        90       100       110
                ....*....|....*....|....*....|....
gi 47550831 265 NVKAYFKRGKAHAAVWNEAEARADFAKVLTLDPS 298
Cdd:COG0457  75 DAEALNNLGLALQALGRYEEALEDYDKALELDPD 108
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 138-297 1.17e-03

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 39.17  E-value: 1.17e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550831 138 DLDKLQSNPQPLIFTLELLQVLSPGSYQQEIWAMTDDEKLGAIPQIHEEGNALFKSGDISGAAEKYYNAIAClkslqmke 217
Cdd:COG5010  12 LYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQL-------- 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550831 218 RPGDehwikldlmiTPLLLNYCQCKLLLGQYYEVLDHCSSIINKYEDNVKAYFKRGKAHAAVWNEAEARADFAKVLTLDP 297
Cdd:COG5010  84 DPNN----------PELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTSP 153
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 189-309 1.41e-03

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 38.05  E-value: 1.41e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550831 189 ALFKSGDisgaaekYYNAIACLKSLqMKERPGDEHwikldlmITPLLLNYCQCKLLLGQYYEVLDHCSSIINKYEDNVK- 267
Cdd:COG1729   2 ALLKAGD-------YDEAIAAFKAF-LKRYPNSPL-------APDALYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPKa 66

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 47550831 268 --AYFKRGKAHAAVWNEAEARADFAKVLTLDP-SLEASIAKELRA 309
Cdd:COG1729  67 pdALLKLGLSYLELGDYDKARATLEELIKKYPdSEAAKEARARLA 111
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
185-302 2.03e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 39.22  E-value: 2.03e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550831 185 EEGNALFKSGDISGAAEKYYNAIACLkslqmkerpgdEHWIKLDLMITPLLLNYCQCKLLLGQYYEVLDHCSSIINKYED 264
Cdd:COG0457  40 DDAEALYNLGLAYLRLGRYEEALADY-----------EQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPD 108

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 47550831 265 NVKAYFKRGKAHAAVWNEAEARADFAKVLTLDPSLEAS 302
Cdd:COG0457 109 DAEALYNLGLALLELGRYDEAIEAYERALELDPDDADA 146
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
264-297 2.59e-03

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 38.74  E-value: 2.59e-03
                        10        20        30
                ....*....|....*....|....*....|....
gi 47550831 264 DNVKAYFKRGKAHAAVWNEAEARADFAKVLTLDP 297
Cdd:COG4785  71 DLAQLYYERGVAYDSLGDYDLAIADFDQALELDP 104
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
183-298 4.20e-03

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 37.97  E-value: 4.20e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550831 183 IHEEGNALFKSGDISGAAEKYYNAIaclkslqmKERPGDehwikldlmitPLLLNY---CQckLLLGQYYEVLDHCSSII 259
Cdd:COG4785  76 YYERGVAYDSLGDYDLAIADFDQAL--------ELDPDL-----------AEAYNNrglAY--LLLGDYDAALEDFDRAL 134

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 47550831 260 NKYEDNVKAYFKRGKAHAAVWNEAEARADFAKVLTLDPS 298
Cdd:COG4785 135 ELDPDYAYAYLNRGIALYYLGRYELAIADLEKALELDPN 173
COG4700 COG4700
Uncharacterized conserved protein ECs_4300, contains TPR-like domain [Function unknown];
187-301 7.75e-03

Uncharacterized conserved protein ECs_4300, contains TPR-like domain [Function unknown];


Pssm-ID: 443735 [Multi-domain]  Cd Length: 249  Bit Score: 37.55  E-value: 7.75e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550831 187 GNALFKSGDISGAAEKYynaIACLKSLQmkerPGDEHwikldlmitpLLLNYCQCKLLLGQYYEVLDHCSSIINKYEDnv 266
Cdd:COG4700  96 ADALLELGRYDEAIELY---EEALTGIF----ADDPH----------ILLGLAQALFELGRYAEALETLEKLIAKNPD-- 156

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 47550831 267 kayFKRGKAH-------AAVWNEAEARADFAKVLTLDPSLEA 301
Cdd:COG4700 157 ---FKSSDAHllyaralEALGDLEAAEAELEALARRYSGPEA 195
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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