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Conserved domains on  [gi|589269144|ref|NP_997918|]
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proteoglycan 4a precursor [Danio rerio]

Protein Classification

Somatomedin_B and HX domain-containing protein( domain architecture ID 10470576)

Somatomedin_B and HX domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HX super family cl02471
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 252-372 4.34e-25

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


The actual alignment was detected with superfamily member cd00094:

Pssm-ID: 413329 [Multi-domain]  Cd Length: 194  Bit Score: 102.00  E-value: 4.34e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589269144 252 NLCSGVVIDGMAALfNGSIIVFRGHFFWLLNPKTRRAGPaRRITEEL-GVPSPIDTAFTRCNcQGKTYIIKGDSYWSFEN 330
Cdd:cd00094    2 DACDPLSFDAVTTL-RGELYFFKGRYFWRLSPGKPPGSP-FLISSFWpSLPSPVDAAFERPD-TGKIYFFKGDKYWVYTG 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 589269144 331 GVLESGYPRSVSqDFGGLS--GDITAALPvpatRKRPESVYFFK 372
Cdd:cd00094   79 KNLEPGYPKPIS-DLGFPPtvKQIDAALR----WPDNGKTYFFK 117
Somatomedin_B pfam01033
Somatomedin B domain;
65-101 2.35e-14

Somatomedin B domain;


:

Pssm-ID: 460034  Cd Length: 40  Bit Score: 66.94  E-value: 2.35e-14
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 589269144   65 ESCRGRCGEPFRRGRQCECDSGCVLHNSCCPDYSTHC 101
Cdd:pfam01033   1 ESCKGRCGESFDRGRLCQCDDDCVKYGDCCPDYESLC 37
Somatomedin_B pfam01033
Somatomedin B domain;
25-64 9.33e-13

Somatomedin B domain;


:

Pssm-ID: 460034  Cd Length: 40  Bit Score: 62.32  E-value: 9.33e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 589269144   25 GSCVGRCGEQFSRGHICNCDYNCFVHGECCKDFEDICTAS 64
Cdd:pfam01033   1 ESCKGRCGESFDRGRLCQCDDDCVKYGDCCPDYESLCLGE 40
 
Name Accession Description Interval E-value
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 252-372 4.34e-25

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 102.00  E-value: 4.34e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589269144 252 NLCSGVVIDGMAALfNGSIIVFRGHFFWLLNPKTRRAGPaRRITEEL-GVPSPIDTAFTRCNcQGKTYIIKGDSYWSFEN 330
Cdd:cd00094    2 DACDPLSFDAVTTL-RGELYFFKGRYFWRLSPGKPPGSP-FLISSFWpSLPSPVDAAFERPD-TGKIYFFKGDKYWVYTG 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 589269144 331 GVLESGYPRSVSqDFGGLS--GDITAALPvpatRKRPESVYFFK 372
Cdd:cd00094   79 KNLEPGYPKPIS-DLGFPPtvKQIDAALR----WPDNGKTYFFK 117
Somatomedin_B pfam01033
Somatomedin B domain;
65-101 2.35e-14

Somatomedin B domain;


Pssm-ID: 460034  Cd Length: 40  Bit Score: 66.94  E-value: 2.35e-14
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 589269144   65 ESCRGRCGEPFRRGRQCECDSGCVLHNSCCPDYSTHC 101
Cdd:pfam01033   1 ESCKGRCGESFDRGRLCQCDDDCVKYGDCCPDYESLC 37
Somatomedin_B pfam01033
Somatomedin B domain;
25-64 9.33e-13

Somatomedin B domain;


Pssm-ID: 460034  Cd Length: 40  Bit Score: 62.32  E-value: 9.33e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 589269144   25 GSCVGRCGEQFSRGHICNCDYNCFVHGECCKDFEDICTAS 64
Cdd:pfam01033   1 ESCKGRCGESFDRGRLCQCDDDCVKYGDCCPDYESLCLGE 40
SO smart00201
Somatomedin B -like domains; Somatomedin-B is a peptide, proteolytically excised from ...
 23-65 1.42e-11

Somatomedin B -like domains; Somatomedin-B is a peptide, proteolytically excised from vitronectin, that is a growth hormone-dependent serum factor with protease-inhibiting activity.


Pssm-ID: 197571  Cd Length: 43  Bit Score: 58.92  E-value: 1.42e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 589269144    23 AQGSCVGRCGEQFSRGHICNCDYNCFVHGECCKDFEDICTASE 65
Cdd:smart00201   1 AIGSCKGRCGESFNEGNACRCDALCLSYGDCCTDYESVCKKEV 43
SO smart00201
Somatomedin B -like domains; Somatomedin-B is a peptide, proteolytically excised from ...
 63-101 1.61e-09

Somatomedin B -like domains; Somatomedin-B is a peptide, proteolytically excised from vitronectin, that is a growth hormone-dependent serum factor with protease-inhibiting activity.


Pssm-ID: 197571  Cd Length: 43  Bit Score: 53.15  E-value: 1.61e-09
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 589269144    63 ASESCRGRCGEPFRRGRQCECDSGCVLHNSCCPDYSTHC 101
Cdd:smart00201   1 AIGSCKGRCGESFNEGNACRCDALCLSYGDCCTDYESVC 39
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 304-348 6.37e-08

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 48.78  E-value: 6.37e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 589269144   304 IDTAFTRCNcqGKTYIIKGDSYWSFENGVLESGYPRSVSQDFGGL 348
Cdd:smart00120   1 IDAAFELRD--GKTYFFKGDKYWRFDPKRVDPGYPKLISSFFPGL 43
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 304-346 1.65e-06

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 44.86  E-value: 1.65e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 589269144  304 IDTAFTRCNcqGKTYIIKGDSYWSFENGVLESGYPRSVSQDFG 346
Cdd:pfam00045   1 IDAAFEDRD--GKTYFFKGRKYWRFDPQRVEPGYPKLISDFPG 41
 
Name Accession Description Interval E-value
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 252-372 4.34e-25

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 102.00  E-value: 4.34e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589269144 252 NLCSGVVIDGMAALfNGSIIVFRGHFFWLLNPKTRRAGPaRRITEEL-GVPSPIDTAFTRCNcQGKTYIIKGDSYWSFEN 330
Cdd:cd00094    2 DACDPLSFDAVTTL-RGELYFFKGRYFWRLSPGKPPGSP-FLISSFWpSLPSPVDAAFERPD-TGKIYFFKGDKYWVYTG 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 589269144 331 GVLESGYPRSVSqDFGGLS--GDITAALPvpatRKRPESVYFFK 372
Cdd:cd00094   79 KNLEPGYPKPIS-DLGFPPtvKQIDAALR----WPDNGKTYFFK 117
Somatomedin_B pfam01033
Somatomedin B domain;
65-101 2.35e-14

Somatomedin B domain;


Pssm-ID: 460034  Cd Length: 40  Bit Score: 66.94  E-value: 2.35e-14
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 589269144   65 ESCRGRCGEPFRRGRQCECDSGCVLHNSCCPDYSTHC 101
Cdd:pfam01033   1 ESCKGRCGESFDRGRLCQCDDDCVKYGDCCPDYESLC 37
Somatomedin_B pfam01033
Somatomedin B domain;
25-64 9.33e-13

Somatomedin B domain;


Pssm-ID: 460034  Cd Length: 40  Bit Score: 62.32  E-value: 9.33e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 589269144   25 GSCVGRCGEQFSRGHICNCDYNCFVHGECCKDFEDICTAS 64
Cdd:pfam01033   1 ESCKGRCGESFDRGRLCQCDDDCVKYGDCCPDYESLCLGE 40
SO smart00201
Somatomedin B -like domains; Somatomedin-B is a peptide, proteolytically excised from ...
 23-65 1.42e-11

Somatomedin B -like domains; Somatomedin-B is a peptide, proteolytically excised from vitronectin, that is a growth hormone-dependent serum factor with protease-inhibiting activity.


Pssm-ID: 197571  Cd Length: 43  Bit Score: 58.92  E-value: 1.42e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 589269144    23 AQGSCVGRCGEQFSRGHICNCDYNCFVHGECCKDFEDICTASE 65
Cdd:smart00201   1 AIGSCKGRCGESFNEGNACRCDALCLSYGDCCTDYESVCKKEV 43
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 259-345 8.11e-10

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 58.48  E-value: 8.11e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589269144 259 IDgmAALF---NGSIIVFRGHFFWLLNPKTRR---AGPARRITEELGVPSPIDTAFtrCNCQGKTYIIKGDSYWSFEN-- 330
Cdd:cd00094  101 ID--AALRwpdNGKTYFFKGDKYWRYDEKTQKmdpGYPKLIETDFPGVPDKVDAAF--RWLDGYYYFFKGDQYWRFDPrs 176

                         90
                 ....*....|....*
gi 589269144 331 GVLESGYPRSVSQDF 345
Cdd:cd00094  177 KEVRVGYPLKISSDW 191
SO smart00201
Somatomedin B -like domains; Somatomedin-B is a peptide, proteolytically excised from ...
 63-101 1.61e-09

Somatomedin B -like domains; Somatomedin-B is a peptide, proteolytically excised from vitronectin, that is a growth hormone-dependent serum factor with protease-inhibiting activity.


Pssm-ID: 197571  Cd Length: 43  Bit Score: 53.15  E-value: 1.61e-09
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 589269144    63 ASESCRGRCGEPFRRGRQCECDSGCVLHNSCCPDYSTHC 101
Cdd:smart00201   1 AIGSCKGRCGESFNEGNACRCDALCLSYGDCCTDYESVC 39
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 304-348 6.37e-08

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 48.78  E-value: 6.37e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 589269144   304 IDTAFTRCNcqGKTYIIKGDSYWSFENGVLESGYPRSVSQDFGGL 348
Cdd:smart00120   1 IDAAFELRD--GKTYFFKGDKYWRFDPKRVDPGYPKLISSFFPGL 43
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 304-346 1.65e-06

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 44.86  E-value: 1.65e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 589269144  304 IDTAFTRCNcqGKTYIIKGDSYWSFENGVLESGYPRSVSQDFG 346
Cdd:pfam00045   1 IDAAFEDRD--GKTYFFKGRKYWRFDPQRVEPGYPKLISDFPG 41
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 259-302 2.21e-03

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 36.07  E-value: 2.21e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 589269144   259 IDGMAALFNGSIIVFRGHFFWLLNPKTRRAGPARRITEE-LGVPS 302
Cdd:smart00120   1 IDAAFELRDGKTYFFKGDKYWRFDPKRVDPGYPKLISSFfPGLPC 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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