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Conserved domains on  [gi|47059011|ref|NP_997651|]
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GTPase IMAP family member 8 isoform 1 [Mus musculus]

Protein Classification

GTPase IMAP family protein( domain architecture ID 10111261)

GTPase immunity-associated protein (IMAP) family protein may function as regulator of lymphocyte survival and homeostasis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AIG1 cd01852
AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 ...
 49-248 8.65e-84

AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 (avrRpt2-induced gene 1) that appears to be involved in plant resistance to bacteria. The Arabidopsis disease resistance gene RPS2 is involved in recognition of bacterial pathogens carrying the avirulence gene avrRpt2. AIG1 exhibits RPS2- and avrRpt1-dependent induction early after infection with Pseudomonas syringae carrying avrRpt2. This subfamily also includes IAN-4 protein, which has GTP-binding activity and shares sequence homology with a novel family of putative GTP-binding proteins: the immuno-associated nucleotide (IAN) family. The evolutionary conservation of the IAN family provides a unique example of a plant pathogen response gene conserved in animals. The IAN/IMAP subfamily has been proposed to regulate apoptosis in vertebrates and angiosperm plants, particularly in relation to cancer, diabetes, and infections. The human IAN genes were renamed GIMAP (GTPase of the immunity associated proteins).


:

Pssm-ID: 206651 [Multi-domain]  Cd Length: 201  Bit Score: 262.86  E-value: 8.65e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059011  49 LRLLLLGKQGAGKSATGNTILGKAVFESKFSDHMVTDRCQSESVSVRGKQVIVIDTPDLFSSLSCSEVRQQNLKQCLELL 128
Cdd:cd01852   1 LRLVLVGKTGNGKSATGNTILGRKVFESKLSASGVTKTCQKESAVWDGRRVNVIDTPGLFDTSVSPEQLSKEIIRCLSLS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059011 129 ADDHCVLLLVTPIGHYTEEDRETIEGIWGKIGPKAYRHMIVVFTREDELDEDSLWNYIE-SKESLKELIKnIGSRRCCTF 207
Cdd:cd01852  81 APGPHAFLLVVPLGRFTEEEEQAVEELQELFGEKVLDHTIVLFTRGDDLEGGSLEDYLEdSCEALKRLLE-KCGGRYVAF 159

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 47059011 208 NNKADKKQRELQVFKLLDAIELLMME-SPEPYFEPLKMESSG 248
Cdd:cd01852 160 NNKAKGREQEQQVKELLAKVEEMVREnGGKPYTNEMYEEAEE 201
AIG1 cd01852
AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 ...
 285-478 3.37e-73

AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 (avrRpt2-induced gene 1) that appears to be involved in plant resistance to bacteria. The Arabidopsis disease resistance gene RPS2 is involved in recognition of bacterial pathogens carrying the avirulence gene avrRpt2. AIG1 exhibits RPS2- and avrRpt1-dependent induction early after infection with Pseudomonas syringae carrying avrRpt2. This subfamily also includes IAN-4 protein, which has GTP-binding activity and shares sequence homology with a novel family of putative GTP-binding proteins: the immuno-associated nucleotide (IAN) family. The evolutionary conservation of the IAN family provides a unique example of a plant pathogen response gene conserved in animals. The IAN/IMAP subfamily has been proposed to regulate apoptosis in vertebrates and angiosperm plants, particularly in relation to cancer, diabetes, and infections. The human IAN genes were renamed GIMAP (GTPase of the immunity associated proteins).


:

Pssm-ID: 206651 [Multi-domain]  Cd Length: 201  Bit Score: 235.12  E-value: 3.37e-73
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059011 285 LRVLLMGKRGVGKSAAGNSILGKQVFKTQFSeKQRVTKAFASHSRVWQGKKVLIIDSPEISSWKLDESAVK-------NH 357
Cdd:cd01852   1 LRLVLVGKTGNGKSATGNTILGRKVFESKLS-ASGVTKTCQKESAVWDGRRVNVIDTPGLFDTSVSPEQLSkeiirclSL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059011 358 TFPGPHAFLLVTPLGSSLKSDDDVFSIIKRIFGEKFTKFTIVLFTRKEDFEDQALDKVIKEND-ALYNLTQKFGERYAIF 436
Cdd:cd01852  80 SAPGPHAFLLVVPLGRFTEEEEQAVEELQELFGEKVLDHTIVLFTRGDDLEGGSLEDYLEDSCeALKRLLEKCGGRYVAF 159

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 47059011 437 NYRASVEEEQSQVGKLLSQIEKMVQCHSNKPCVIREKELLNI 478
Cdd:cd01852 160 NNKAKGREQEQQVKELLAKVEEMVRENGGKPYTNEMYEEAEE 201
AIG1 cd01852
AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 ...
 476-664 8.16e-73

AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 (avrRpt2-induced gene 1) that appears to be involved in plant resistance to bacteria. The Arabidopsis disease resistance gene RPS2 is involved in recognition of bacterial pathogens carrying the avirulence gene avrRpt2. AIG1 exhibits RPS2- and avrRpt1-dependent induction early after infection with Pseudomonas syringae carrying avrRpt2. This subfamily also includes IAN-4 protein, which has GTP-binding activity and shares sequence homology with a novel family of putative GTP-binding proteins: the immuno-associated nucleotide (IAN) family. The evolutionary conservation of the IAN family provides a unique example of a plant pathogen response gene conserved in animals. The IAN/IMAP subfamily has been proposed to regulate apoptosis in vertebrates and angiosperm plants, particularly in relation to cancer, diabetes, and infections. The human IAN genes were renamed GIMAP (GTPase of the immunity associated proteins).


:

Pssm-ID: 206651 [Multi-domain]  Cd Length: 201  Bit Score: 233.97  E-value: 8.16e-73
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059011 476 LNIILLGRSGAGKSATGNTILGRSAFFSQLRAQPVTSSSQSGKRTLDWQDVVVVDTPSFIQTpgtEKDPSRLKEEIHHCL 555
Cdd:cd01852   1 LRLVLVGKTGNGKSATGNTILGRKVFESKLSASGVTKTCQKESAVWDGRRVNVIDTPGLFDT---SVSPEQLSKEIIRCL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059011 556 SLCEEGMKIFVLVLQLGRFTQEDEVVVEQLEASFEENIMKYMIVLFTRKEDLGDGDLHDYTNNTkNKALKKILKKCNGRV 635
Cdd:cd01852  78 SLSAPGPHAFLLVVPLGRFTEEEEQAVEELQELFGEKVLDHTIVLFTRGDDLEGGSLEDYLEDS-CEALKRLLEKCGGRY 156

                       170       180       190
                ....*....|....*....|....*....|
gi 47059011 636 CAFNNKETGEDQETQVKGLL-KIANSLKKN 664
Cdd:cd01852 157 VAFNNKAKGREQEQQVKELLaKVEEMVREN 186
 
Name Accession Description Interval E-value
AIG1 cd01852
AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 ...
 49-248 8.65e-84

AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 (avrRpt2-induced gene 1) that appears to be involved in plant resistance to bacteria. The Arabidopsis disease resistance gene RPS2 is involved in recognition of bacterial pathogens carrying the avirulence gene avrRpt2. AIG1 exhibits RPS2- and avrRpt1-dependent induction early after infection with Pseudomonas syringae carrying avrRpt2. This subfamily also includes IAN-4 protein, which has GTP-binding activity and shares sequence homology with a novel family of putative GTP-binding proteins: the immuno-associated nucleotide (IAN) family. The evolutionary conservation of the IAN family provides a unique example of a plant pathogen response gene conserved in animals. The IAN/IMAP subfamily has been proposed to regulate apoptosis in vertebrates and angiosperm plants, particularly in relation to cancer, diabetes, and infections. The human IAN genes were renamed GIMAP (GTPase of the immunity associated proteins).


Pssm-ID: 206651 [Multi-domain]  Cd Length: 201  Bit Score: 262.86  E-value: 8.65e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059011  49 LRLLLLGKQGAGKSATGNTILGKAVFESKFSDHMVTDRCQSESVSVRGKQVIVIDTPDLFSSLSCSEVRQQNLKQCLELL 128
Cdd:cd01852   1 LRLVLVGKTGNGKSATGNTILGRKVFESKLSASGVTKTCQKESAVWDGRRVNVIDTPGLFDTSVSPEQLSKEIIRCLSLS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059011 129 ADDHCVLLLVTPIGHYTEEDRETIEGIWGKIGPKAYRHMIVVFTREDELDEDSLWNYIE-SKESLKELIKnIGSRRCCTF 207
Cdd:cd01852  81 APGPHAFLLVVPLGRFTEEEEQAVEELQELFGEKVLDHTIVLFTRGDDLEGGSLEDYLEdSCEALKRLLE-KCGGRYVAF 159

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 47059011 208 NNKADKKQRELQVFKLLDAIELLMME-SPEPYFEPLKMESSG 248
Cdd:cd01852 160 NNKAKGREQEQQVKELLAKVEEMVREnGGKPYTNEMYEEAEE 201
AIG1 cd01852
AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 ...
 285-478 3.37e-73

AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 (avrRpt2-induced gene 1) that appears to be involved in plant resistance to bacteria. The Arabidopsis disease resistance gene RPS2 is involved in recognition of bacterial pathogens carrying the avirulence gene avrRpt2. AIG1 exhibits RPS2- and avrRpt1-dependent induction early after infection with Pseudomonas syringae carrying avrRpt2. This subfamily also includes IAN-4 protein, which has GTP-binding activity and shares sequence homology with a novel family of putative GTP-binding proteins: the immuno-associated nucleotide (IAN) family. The evolutionary conservation of the IAN family provides a unique example of a plant pathogen response gene conserved in animals. The IAN/IMAP subfamily has been proposed to regulate apoptosis in vertebrates and angiosperm plants, particularly in relation to cancer, diabetes, and infections. The human IAN genes were renamed GIMAP (GTPase of the immunity associated proteins).


Pssm-ID: 206651 [Multi-domain]  Cd Length: 201  Bit Score: 235.12  E-value: 3.37e-73
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059011 285 LRVLLMGKRGVGKSAAGNSILGKQVFKTQFSeKQRVTKAFASHSRVWQGKKVLIIDSPEISSWKLDESAVK-------NH 357
Cdd:cd01852   1 LRLVLVGKTGNGKSATGNTILGRKVFESKLS-ASGVTKTCQKESAVWDGRRVNVIDTPGLFDTSVSPEQLSkeiirclSL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059011 358 TFPGPHAFLLVTPLGSSLKSDDDVFSIIKRIFGEKFTKFTIVLFTRKEDFEDQALDKVIKEND-ALYNLTQKFGERYAIF 436
Cdd:cd01852  80 SAPGPHAFLLVVPLGRFTEEEEQAVEELQELFGEKVLDHTIVLFTRGDDLEGGSLEDYLEDSCeALKRLLEKCGGRYVAF 159

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 47059011 437 NYRASVEEEQSQVGKLLSQIEKMVQCHSNKPCVIREKELLNI 478
Cdd:cd01852 160 NNKAKGREQEQQVKELLAKVEEMVRENGGKPYTNEMYEEAEE 201
AIG1 cd01852
AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 ...
 476-664 8.16e-73

AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 (avrRpt2-induced gene 1) that appears to be involved in plant resistance to bacteria. The Arabidopsis disease resistance gene RPS2 is involved in recognition of bacterial pathogens carrying the avirulence gene avrRpt2. AIG1 exhibits RPS2- and avrRpt1-dependent induction early after infection with Pseudomonas syringae carrying avrRpt2. This subfamily also includes IAN-4 protein, which has GTP-binding activity and shares sequence homology with a novel family of putative GTP-binding proteins: the immuno-associated nucleotide (IAN) family. The evolutionary conservation of the IAN family provides a unique example of a plant pathogen response gene conserved in animals. The IAN/IMAP subfamily has been proposed to regulate apoptosis in vertebrates and angiosperm plants, particularly in relation to cancer, diabetes, and infections. The human IAN genes were renamed GIMAP (GTPase of the immunity associated proteins).


Pssm-ID: 206651 [Multi-domain]  Cd Length: 201  Bit Score: 233.97  E-value: 8.16e-73
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059011 476 LNIILLGRSGAGKSATGNTILGRSAFFSQLRAQPVTSSSQSGKRTLDWQDVVVVDTPSFIQTpgtEKDPSRLKEEIHHCL 555
Cdd:cd01852   1 LRLVLVGKTGNGKSATGNTILGRKVFESKLSASGVTKTCQKESAVWDGRRVNVIDTPGLFDT---SVSPEQLSKEIIRCL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059011 556 SLCEEGMKIFVLVLQLGRFTQEDEVVVEQLEASFEENIMKYMIVLFTRKEDLGDGDLHDYTNNTkNKALKKILKKCNGRV 635
Cdd:cd01852  78 SLSAPGPHAFLLVVPLGRFTEEEEQAVEELQELFGEKVLDHTIVLFTRGDDLEGGSLEDYLEDS-CEALKRLLEKCGGRY 156

                       170       180       190
                ....*....|....*....|....*....|
gi 47059011 636 CAFNNKETGEDQETQVKGLL-KIANSLKKN 664
Cdd:cd01852 157 VAFNNKAKGREQEQQVKELLaKVEEMVREN 186
AIG1 pfam04548
AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.
 476-664 3.99e-63

AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.


Pssm-ID: 398307 [Multi-domain]  Cd Length: 200  Bit Score: 208.23  E-value: 3.99e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059011   476 LNIILLGRSGAGKSATGNTILGRSAFFSQLRAQPVTSSSQSGKRTLDWQDVVVVDTPSFIQTpgtEKDPSRLKEEIHHCL 555
Cdd:pfam04548   1 LRIVLVGKTGNGKSATGNSILGRKAFESKLRAQGVTKTCQLVSRTWDGRIINVIDTPGLFDL---SVSNDFISKEIIRCL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059011   556 SLCEEGMKIFVLVLQLGRFTQEDEVVVEQLEASFEENIMKYMIVLFTRKEDLGDGDLHDYTNNTKNKALKKILKkcngrv 635
Cdd:pfam04548  78 LLAEPGPHAVLLVLSLGRFTEEEEQALRTLQELFGSKILDYMIVVFTRKDDLEDDSLDDYLSDGCPEFLKEVLR------ 151

                         170       180       190
                  ....*....|....*....|....*....|
gi 47059011   636 cafnnKETGEDQETQVKGLL-KIANSLKKN 664
Cdd:pfam04548 152 -----TADGEEKEEQVQQLLaLVEAIVKEN 176
AIG1 pfam04548
AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.
 49-239 7.80e-51

AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.


Pssm-ID: 398307 [Multi-domain]  Cd Length: 200  Bit Score: 175.49  E-value: 7.80e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059011    49 LRLLLLGKQGAGKSATGNTILGKAVFESKFSDHMVTDRCQSESVSVRGKQVIVIDTPDLFSSLSCSEVRQQNLKQCLELL 128
Cdd:pfam04548   1 LRIVLVGKTGNGKSATGNSILGRKAFESKLRAQGVTKTCQLVSRTWDGRIINVIDTPGLFDLSVSNDFISKEIIRCLLLA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059011   129 ADDHCVLLLVTPIGHYTEEDRETIEGIWGKIGPKAYRHMIVVFTREDELDEDSLWNYIE--SKESLKELIKnigsrrcct 206
Cdd:pfam04548  81 EPGPHAVLLVLSLGRFTEEEEQALRTLQELFGSKILDYMIVVFTRKDDLEDDSLDDYLSdgCPEFLKEVLR--------- 151

                         170       180       190
                  ....*....|....*....|....*....|...
gi 47059011   207 fnnKADKKQRELQVFKLLDAIELLMMESPEPYF 239
Cdd:pfam04548 152 ---TADGEEKEEQVQQLLALVEAIVKENGGKPY 181
AIG1 pfam04548
AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.
 285-467 1.14e-48

AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.


Pssm-ID: 398307 [Multi-domain]  Cd Length: 200  Bit Score: 169.33  E-value: 1.14e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059011   285 LRVLLMGKRGVGKSAAGNSILGKQVFKTQFSEkQRVTKAFASHSRVWQGKKVLIIDSPEISSWKLDESAVKNH------- 357
Cdd:pfam04548   1 LRIVLVGKTGNGKSATGNSILGRKAFESKLRA-QGVTKTCQLVSRTWDGRIINVIDTPGLFDLSVSNDFISKEiirclll 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059011   358 TFPGPHAFLLVTPLGSSLKSDDDVFSIIKRIFGEKFTKFTIVLFTRKEDFEDQALDKVIKE--NDALYNLTQKfgeryai 435
Cdd:pfam04548  80 AEPGPHAVLLVLSLGRFTEEEEQALRTLQELFGSKILDYMIVVFTRKDDLEDDSLDDYLSDgcPEFLKEVLRT------- 152

                         170       180       190
                  ....*....|....*....|....*....|..
gi 47059011   436 fnyrASVEEEQSQVGKLLSQIEKMVQCHSNKP 467
Cdd:pfam04548 153 ----ADGEEKEEQVQQLLALVEAIVKENGGKP 180
3a0901s02IAP34 TIGR00991
GTP-binding protein (Chloroplast Envelope Protein Translocase); [Transport and binding ...
 24-223 8.03e-07

GTP-binding protein (Chloroplast Envelope Protein Translocase); [Transport and binding proteins, Nucleosides, purines and pyrimidines]


Pssm-ID: 130064  Cd Length: 313  Bit Score: 51.44  E-value: 8.03e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059011    24 VGQGERPSASQGQE----GNFKQnQGTSTLRLLLLGKQGAGKSATGNTILGKAV-----FESKFSDHMVTDRCQSesvsv 94
Cdd:TIGR00991  11 VGIQQFPPATQTKLlellGKLKE-EDVSSLTILVMGKGGVGKSSTVNSIIGERIatvsaFQSEGLRPMMVSRTRA----- 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059011    95 rGKQVIVIDTPDLFSSLSCSEVRQQNLKQCLELLADDhcVLLLVTPIGHYTEE--DRETIEGIWGKIGPKAYRHMIVVFT 172
Cdd:TIGR00991  85 -GFTLNIIDTPGLIEGGYINDQAVNIIKRFLLGKTID--VLLYVDRLDAYRVDtlDGQVIRAITDSFGKDIWRKSLVVLT 161

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 47059011   173 REDELDEDSL-WNYIESKESlKELIKNIGSrrcctfnnKADKKQRELQVFKL 223
Cdd:TIGR00991 162 HAQFSPPDGLeYNDFFSKRS-EALLRVIHS--------GAGLKKRDYQDFPI 204
3a0901s04IAP86 TIGR00993
chloroplast protein import component Toc86/159, G and M domains; The long precursor of the 86K ...
 266-352 2.43e-06

chloroplast protein import component Toc86/159, G and M domains; The long precursor of the 86K protein originally described is proposed to have three domains. The N-terminal A-domain is acidic, repetitive, weakly conserved, readily removed by proteolysis during chloroplast isolation, and not required for protein translocation. The other domains are designated G (GTPase) and M (membrane anchor); this family includes most of the G domain and all of M. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273381 [Multi-domain]  Cd Length: 763  Bit Score: 50.72  E-value: 2.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059011   266 SKKRQPQITGPDCDPDMPELRVLLMGKRGVGKSAAGNSILGKQvfKTQFSEKQRVTKAFASHSRVWQGKKVLIIDSPEIS 345
Cdd:TIGR00993 100 AKAMAEQLEAEGQDPLDFSLNILVLGKSGVGKSATINSIFGEV--KFSTDAFGMGTTSVQEIEGLVQGVKIRVIDTPGLK 177


                  ....*..
gi 47059011   346 SWKLDES 352
Cdd:TIGR00993 178 SSASDQS 184
3a0901s04IAP86 TIGR00993
chloroplast protein import component Toc86/159, G and M domains; The long precursor of the 86K ...
 476-532 7.34e-05

chloroplast protein import component Toc86/159, G and M domains; The long precursor of the 86K protein originally described is proposed to have three domains. The N-terminal A-domain is acidic, repetitive, weakly conserved, readily removed by proteolysis during chloroplast isolation, and not required for protein translocation. The other domains are designated G (GTPase) and M (membrane anchor); this family includes most of the G domain and all of M. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273381 [Multi-domain]  Cd Length: 763  Bit Score: 46.10  E-value: 7.34e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 47059011   476 LNIILLGRSGAGKSATGNTILGRSAfFSQLRAQPVTSSSQSGKRTLDWQDVVVVDTP 532
Cdd:TIGR00993 119 LNILVLGKSGVGKSATINSIFGEVK-FSTDAFGMGTTSVQEIEGLVQGVKIRVIDTP 174
YeeP COG3596
Predicted GTPase [General function prediction only];
283-370 6.95e-03

Predicted GTPase [General function prediction only];


Pssm-ID: 442815 [Multi-domain]  Cd Length: 318  Bit Score: 38.98  E-value: 6.95e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059011 283 PELRVLLMGKRGVGKSAAGNSILGKQVFKTqfSEKQRVTKAFASHsrVWQ---GKKVLIIDSP---EISSWKLDESAVKN 356
Cdd:COG3596  38 PPPVIALVGKTGAGKSSLINALFGAEVAEV--GVGRPCTREIQRY--RLEsdgLPGLVLLDTPglgEVNERDREYRELRE 113

                        90
                ....*....|....
gi 47059011 357 HTfPGPHAFLLVTP 370
Cdd:COG3596 114 LL-PEADLILWVVK 126
 
Name Accession Description Interval E-value
AIG1 cd01852
AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 ...
 49-248 8.65e-84

AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 (avrRpt2-induced gene 1) that appears to be involved in plant resistance to bacteria. The Arabidopsis disease resistance gene RPS2 is involved in recognition of bacterial pathogens carrying the avirulence gene avrRpt2. AIG1 exhibits RPS2- and avrRpt1-dependent induction early after infection with Pseudomonas syringae carrying avrRpt2. This subfamily also includes IAN-4 protein, which has GTP-binding activity and shares sequence homology with a novel family of putative GTP-binding proteins: the immuno-associated nucleotide (IAN) family. The evolutionary conservation of the IAN family provides a unique example of a plant pathogen response gene conserved in animals. The IAN/IMAP subfamily has been proposed to regulate apoptosis in vertebrates and angiosperm plants, particularly in relation to cancer, diabetes, and infections. The human IAN genes were renamed GIMAP (GTPase of the immunity associated proteins).


Pssm-ID: 206651 [Multi-domain]  Cd Length: 201  Bit Score: 262.86  E-value: 8.65e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059011  49 LRLLLLGKQGAGKSATGNTILGKAVFESKFSDHMVTDRCQSESVSVRGKQVIVIDTPDLFSSLSCSEVRQQNLKQCLELL 128
Cdd:cd01852   1 LRLVLVGKTGNGKSATGNTILGRKVFESKLSASGVTKTCQKESAVWDGRRVNVIDTPGLFDTSVSPEQLSKEIIRCLSLS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059011 129 ADDHCVLLLVTPIGHYTEEDRETIEGIWGKIGPKAYRHMIVVFTREDELDEDSLWNYIE-SKESLKELIKnIGSRRCCTF 207
Cdd:cd01852  81 APGPHAFLLVVPLGRFTEEEEQAVEELQELFGEKVLDHTIVLFTRGDDLEGGSLEDYLEdSCEALKRLLE-KCGGRYVAF 159

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 47059011 208 NNKADKKQRELQVFKLLDAIELLMME-SPEPYFEPLKMESSG 248
Cdd:cd01852 160 NNKAKGREQEQQVKELLAKVEEMVREnGGKPYTNEMYEEAEE 201
AIG1 cd01852
AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 ...
 285-478 3.37e-73

AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 (avrRpt2-induced gene 1) that appears to be involved in plant resistance to bacteria. The Arabidopsis disease resistance gene RPS2 is involved in recognition of bacterial pathogens carrying the avirulence gene avrRpt2. AIG1 exhibits RPS2- and avrRpt1-dependent induction early after infection with Pseudomonas syringae carrying avrRpt2. This subfamily also includes IAN-4 protein, which has GTP-binding activity and shares sequence homology with a novel family of putative GTP-binding proteins: the immuno-associated nucleotide (IAN) family. The evolutionary conservation of the IAN family provides a unique example of a plant pathogen response gene conserved in animals. The IAN/IMAP subfamily has been proposed to regulate apoptosis in vertebrates and angiosperm plants, particularly in relation to cancer, diabetes, and infections. The human IAN genes were renamed GIMAP (GTPase of the immunity associated proteins).


Pssm-ID: 206651 [Multi-domain]  Cd Length: 201  Bit Score: 235.12  E-value: 3.37e-73
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059011 285 LRVLLMGKRGVGKSAAGNSILGKQVFKTQFSeKQRVTKAFASHSRVWQGKKVLIIDSPEISSWKLDESAVK-------NH 357
Cdd:cd01852   1 LRLVLVGKTGNGKSATGNTILGRKVFESKLS-ASGVTKTCQKESAVWDGRRVNVIDTPGLFDTSVSPEQLSkeiirclSL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059011 358 TFPGPHAFLLVTPLGSSLKSDDDVFSIIKRIFGEKFTKFTIVLFTRKEDFEDQALDKVIKEND-ALYNLTQKFGERYAIF 436
Cdd:cd01852  80 SAPGPHAFLLVVPLGRFTEEEEQAVEELQELFGEKVLDHTIVLFTRGDDLEGGSLEDYLEDSCeALKRLLEKCGGRYVAF 159

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 47059011 437 NYRASVEEEQSQVGKLLSQIEKMVQCHSNKPCVIREKELLNI 478
Cdd:cd01852 160 NNKAKGREQEQQVKELLAKVEEMVRENGGKPYTNEMYEEAEE 201
AIG1 cd01852
AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 ...
 476-664 8.16e-73

AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 (avrRpt2-induced gene 1) that appears to be involved in plant resistance to bacteria. The Arabidopsis disease resistance gene RPS2 is involved in recognition of bacterial pathogens carrying the avirulence gene avrRpt2. AIG1 exhibits RPS2- and avrRpt1-dependent induction early after infection with Pseudomonas syringae carrying avrRpt2. This subfamily also includes IAN-4 protein, which has GTP-binding activity and shares sequence homology with a novel family of putative GTP-binding proteins: the immuno-associated nucleotide (IAN) family. The evolutionary conservation of the IAN family provides a unique example of a plant pathogen response gene conserved in animals. The IAN/IMAP subfamily has been proposed to regulate apoptosis in vertebrates and angiosperm plants, particularly in relation to cancer, diabetes, and infections. The human IAN genes were renamed GIMAP (GTPase of the immunity associated proteins).


Pssm-ID: 206651 [Multi-domain]  Cd Length: 201  Bit Score: 233.97  E-value: 8.16e-73
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059011 476 LNIILLGRSGAGKSATGNTILGRSAFFSQLRAQPVTSSSQSGKRTLDWQDVVVVDTPSFIQTpgtEKDPSRLKEEIHHCL 555
Cdd:cd01852   1 LRLVLVGKTGNGKSATGNTILGRKVFESKLSASGVTKTCQKESAVWDGRRVNVIDTPGLFDT---SVSPEQLSKEIIRCL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059011 556 SLCEEGMKIFVLVLQLGRFTQEDEVVVEQLEASFEENIMKYMIVLFTRKEDLGDGDLHDYTNNTkNKALKKILKKCNGRV 635
Cdd:cd01852  78 SLSAPGPHAFLLVVPLGRFTEEEEQAVEELQELFGEKVLDHTIVLFTRGDDLEGGSLEDYLEDS-CEALKRLLEKCGGRY 156

                       170       180       190
                ....*....|....*....|....*....|
gi 47059011 636 CAFNNKETGEDQETQVKGLL-KIANSLKKN 664
Cdd:cd01852 157 VAFNNKAKGREQEQQVKELLaKVEEMVREN 186
AIG1 pfam04548
AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.
 476-664 3.99e-63

AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.


Pssm-ID: 398307 [Multi-domain]  Cd Length: 200  Bit Score: 208.23  E-value: 3.99e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059011   476 LNIILLGRSGAGKSATGNTILGRSAFFSQLRAQPVTSSSQSGKRTLDWQDVVVVDTPSFIQTpgtEKDPSRLKEEIHHCL 555
Cdd:pfam04548   1 LRIVLVGKTGNGKSATGNSILGRKAFESKLRAQGVTKTCQLVSRTWDGRIINVIDTPGLFDL---SVSNDFISKEIIRCL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059011   556 SLCEEGMKIFVLVLQLGRFTQEDEVVVEQLEASFEENIMKYMIVLFTRKEDLGDGDLHDYTNNTKNKALKKILKkcngrv 635
Cdd:pfam04548  78 LLAEPGPHAVLLVLSLGRFTEEEEQALRTLQELFGSKILDYMIVVFTRKDDLEDDSLDDYLSDGCPEFLKEVLR------ 151

                         170       180       190
                  ....*....|....*....|....*....|
gi 47059011   636 cafnnKETGEDQETQVKGLL-KIANSLKKN 664
Cdd:pfam04548 152 -----TADGEEKEEQVQQLLaLVEAIVKEN 176
AIG1 pfam04548
AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.
 49-239 7.80e-51

AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.


Pssm-ID: 398307 [Multi-domain]  Cd Length: 200  Bit Score: 175.49  E-value: 7.80e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059011    49 LRLLLLGKQGAGKSATGNTILGKAVFESKFSDHMVTDRCQSESVSVRGKQVIVIDTPDLFSSLSCSEVRQQNLKQCLELL 128
Cdd:pfam04548   1 LRIVLVGKTGNGKSATGNSILGRKAFESKLRAQGVTKTCQLVSRTWDGRIINVIDTPGLFDLSVSNDFISKEIIRCLLLA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059011   129 ADDHCVLLLVTPIGHYTEEDRETIEGIWGKIGPKAYRHMIVVFTREDELDEDSLWNYIE--SKESLKELIKnigsrrcct 206
Cdd:pfam04548  81 EPGPHAVLLVLSLGRFTEEEEQALRTLQELFGSKILDYMIVVFTRKDDLEDDSLDDYLSdgCPEFLKEVLR--------- 151

                         170       180       190
                  ....*....|....*....|....*....|...
gi 47059011   207 fnnKADKKQRELQVFKLLDAIELLMMESPEPYF 239
Cdd:pfam04548 152 ---TADGEEKEEQVQQLLALVEAIVKENGGKPY 181
AIG1 pfam04548
AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.
 285-467 1.14e-48

AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.


Pssm-ID: 398307 [Multi-domain]  Cd Length: 200  Bit Score: 169.33  E-value: 1.14e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059011   285 LRVLLMGKRGVGKSAAGNSILGKQVFKTQFSEkQRVTKAFASHSRVWQGKKVLIIDSPEISSWKLDESAVKNH------- 357
Cdd:pfam04548   1 LRIVLVGKTGNGKSATGNSILGRKAFESKLRA-QGVTKTCQLVSRTWDGRIINVIDTPGLFDLSVSNDFISKEiirclll 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059011   358 TFPGPHAFLLVTPLGSSLKSDDDVFSIIKRIFGEKFTKFTIVLFTRKEDFEDQALDKVIKE--NDALYNLTQKfgeryai 435
Cdd:pfam04548  80 AEPGPHAVLLVLSLGRFTEEEEQALRTLQELFGSKILDYMIVVFTRKDDLEDDSLDDYLSDgcPEFLKEVLRT------- 152

                         170       180       190
                  ....*....|....*....|....*....|..
gi 47059011   436 fnyrASVEEEQSQVGKLLSQIEKMVQCHSNKP 467
Cdd:pfam04548 153 ----ADGEEKEEQVQQLLALVEAIVKENGGKP 180
Toc34_like cd01853
Translocon at the Outer-envelope membrane of Chloroplasts 34-like (Toc34-like); The Toc34-like ...
 23-172 3.65e-11

Translocon at the Outer-envelope membrane of Chloroplasts 34-like (Toc34-like); The Toc34-like (Translocon at the Outer-envelope membrane of Chloroplasts) family contains several Toc proteins, including Toc34, Toc33, Toc120, Toc159, Toc86, Toc125, and Toc90. The Toc complex at the outer envelope membrane of chloroplasts is a molecular machine of ~500 kDa that contains a single Toc159 protein, four Toc75 molecules, and four or five copies of Toc34. Toc64 and Toc12 are associated with the translocon, but do not appear to be part of the core complex. The Toc translocon initiates the import of nuclear-encoded preproteins from the cytosol into the organelle. Toc34 and Toc159 are both GTPases, while Toc75 is a beta-barrel integral membrane protein. Toc159 is equally distributed between a soluble cytoplasmic form and a membrane-inserted form, suggesting that assembly of the Toc complex is dynamic. Toc34 and Toc75 act sequentially to mediate docking and insertion of Toc159 resulting in assembly of the functional translocon.


Pssm-ID: 206652  Cd Length: 248  Bit Score: 63.88  E-value: 3.65e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059011  23 SVGQGERPSASQG----QEGNFKQnQGTSTLRLLLLGKQGAGKSATGNTILG--KAVFeSKFSDHmvTDRCQSESVSVRG 96
Cdd:cd01853   3 WVGFQFFPDATQTklheLEAKLKK-ELDFSLTILVLGKTGVGKSSTINSIFGerKVSV-SAFQSE--TLRPREVSRTVDG 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059011  97 KQVIVIDTPDLFSSLSCSeVRQQNLKQCLELLAD---DhcVLLLVTPIGHYTEE--DRETIEGIWGKIGPKAYRHMIVVF 171
Cdd:cd01853  79 FKLNIIDTPGLLESQDQR-VNRKILSIIKRFLKKktiD--VVLYVDRLDMYRVDnlDVPLLRAITDSFGPSIWRNAIVVL 155


                .
gi 47059011 172 T 172
Cdd:cd01853 156 T 156
Toc34_like cd01853
Translocon at the Outer-envelope membrane of Chloroplasts 34-like (Toc34-like); The Toc34-like ...
 279-342 2.18e-09

Translocon at the Outer-envelope membrane of Chloroplasts 34-like (Toc34-like); The Toc34-like (Translocon at the Outer-envelope membrane of Chloroplasts) family contains several Toc proteins, including Toc34, Toc33, Toc120, Toc159, Toc86, Toc125, and Toc90. The Toc complex at the outer envelope membrane of chloroplasts is a molecular machine of ~500 kDa that contains a single Toc159 protein, four Toc75 molecules, and four or five copies of Toc34. Toc64 and Toc12 are associated with the translocon, but do not appear to be part of the core complex. The Toc translocon initiates the import of nuclear-encoded preproteins from the cytosol into the organelle. Toc34 and Toc159 are both GTPases, while Toc75 is a beta-barrel integral membrane protein. Toc159 is equally distributed between a soluble cytoplasmic form and a membrane-inserted form, suggesting that assembly of the Toc complex is dynamic. Toc34 and Toc75 act sequentially to mediate docking and insertion of Toc159 resulting in assembly of the functional translocon.


Pssm-ID: 206652  Cd Length: 248  Bit Score: 58.48  E-value: 2.18e-09
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 47059011 279 DPDMPELRVLLMGKRGVGKSAAGNSILGKQvfKTQFSEKQRVTKAFASHSRVWQGKKVLIIDSP 342
Cdd:cd01853  26 KELDFSLTILVLGKTGVGKSSTINSIFGER--KVSVSAFQSETLRPREVSRTVDGFKLNIIDTP 87
3a0901s02IAP34 TIGR00991
GTP-binding protein (Chloroplast Envelope Protein Translocase); [Transport and binding ...
 24-223 8.03e-07

GTP-binding protein (Chloroplast Envelope Protein Translocase); [Transport and binding proteins, Nucleosides, purines and pyrimidines]


Pssm-ID: 130064  Cd Length: 313  Bit Score: 51.44  E-value: 8.03e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059011    24 VGQGERPSASQGQE----GNFKQnQGTSTLRLLLLGKQGAGKSATGNTILGKAV-----FESKFSDHMVTDRCQSesvsv 94
Cdd:TIGR00991  11 VGIQQFPPATQTKLlellGKLKE-EDVSSLTILVMGKGGVGKSSTVNSIIGERIatvsaFQSEGLRPMMVSRTRA----- 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059011    95 rGKQVIVIDTPDLFSSLSCSEVRQQNLKQCLELLADDhcVLLLVTPIGHYTEE--DRETIEGIWGKIGPKAYRHMIVVFT 172
Cdd:TIGR00991  85 -GFTLNIIDTPGLIEGGYINDQAVNIIKRFLLGKTID--VLLYVDRLDAYRVDtlDGQVIRAITDSFGKDIWRKSLVVLT 161

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 47059011   173 REDELDEDSL-WNYIESKESlKELIKNIGSrrcctfnnKADKKQRELQVFKL 223
Cdd:TIGR00991 162 HAQFSPPDGLeYNDFFSKRS-EALLRVIHS--------GAGLKKRDYQDFPI 204
Ras_like_GTPase cd00882
Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like ...
 52-196 1.84e-06

Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras, Rho, Rab, and Sar1/Arf families. This superfamily also includes proteins like the GTP translation factors, Era-like GTPases, and G-alpha chain of the heterotrimeric G proteins. Members of the Ras superfamily regulate a wide variety of cellular functions: the Ras family regulates gene expression, the Rho family regulates cytoskeletal reorganization and gene expression, the Rab and Sar1/Arf families regulate vesicle trafficking, and the Ran family regulates nucleocytoplasmic transport and microtubule organization. The GTP translation factor family regulates initiation, elongation, termination, and release in translation, and the Era-like GTPase family regulates cell division, sporulation, and DNA replication. Members of the Ras superfamily are identified by the GTP binding site, which is made up of five characteristic sequence motifs, and the switch I and switch II regions.


Pssm-ID: 206648 [Multi-domain]  Cd Length: 161  Bit Score: 48.22  E-value: 1.84e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059011  52 LLLGKQGAGKSATGNTILGKAVFESKfSDHMVTDRCQSESVSVRGKQVIV--IDTPDLFsslscSEVRQQNLKQCLELLA 129
Cdd:cd00882   1 VVVGRGGVGKSSLLNALLGGEVGEVS-DVPGTTRDPDVYVKELDKGKVKLvlVDTPGLD-----EFGGLGREELARLLLR 74

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 47059011 130 DDHCVLLLVTPIGHYTEEDRETIEGIWGKIGPKayrHMIVVFTREDELDEDSLWNYIESKESLKELI 196
Cdd:cd00882  75 GADLILLVVDSTDRESEEDAKLLILRRLRKEGI---PIILVGNKIDLLEEREVEELLRLEELAKILG 138
3a0901s04IAP86 TIGR00993
chloroplast protein import component Toc86/159, G and M domains; The long precursor of the 86K ...
 48-112 2.33e-06

chloroplast protein import component Toc86/159, G and M domains; The long precursor of the 86K protein originally described is proposed to have three domains. The N-terminal A-domain is acidic, repetitive, weakly conserved, readily removed by proteolysis during chloroplast isolation, and not required for protein translocation. The other domains are designated G (GTPase) and M (membrane anchor); this family includes most of the G domain and all of M. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273381 [Multi-domain]  Cd Length: 763  Bit Score: 51.11  E-value: 2.33e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 47059011    48 TLRLLLLGKQGAGKSATGNTILGkavfESKFSD---HMVTDRCQSESVSVRGKQVIVIDTPDLFSSLS 112
Cdd:TIGR00993 118 SLNILVLGKSGVGKSATINSIFG----EVKFSTdafGMGTTSVQEIEGLVQGVKIRVIDTPGLKSSAS 181
3a0901s04IAP86 TIGR00993
chloroplast protein import component Toc86/159, G and M domains; The long precursor of the 86K ...
 266-352 2.43e-06

chloroplast protein import component Toc86/159, G and M domains; The long precursor of the 86K protein originally described is proposed to have three domains. The N-terminal A-domain is acidic, repetitive, weakly conserved, readily removed by proteolysis during chloroplast isolation, and not required for protein translocation. The other domains are designated G (GTPase) and M (membrane anchor); this family includes most of the G domain and all of M. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273381 [Multi-domain]  Cd Length: 763  Bit Score: 50.72  E-value: 2.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059011   266 SKKRQPQITGPDCDPDMPELRVLLMGKRGVGKSAAGNSILGKQvfKTQFSEKQRVTKAFASHSRVWQGKKVLIIDSPEIS 345
Cdd:TIGR00993 100 AKAMAEQLEAEGQDPLDFSLNILVLGKSGVGKSATINSIFGEV--KFSTDAFGMGTTSVQEIEGLVQGVKIRVIDTPGLK 177


                  ....*..
gi 47059011   346 SWKLDES 352
Cdd:TIGR00993 178 SSASDQS 184
Ras_like_GTPase cd00882
Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like ...
 480-642 2.70e-06

Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras, Rho, Rab, and Sar1/Arf families. This superfamily also includes proteins like the GTP translation factors, Era-like GTPases, and G-alpha chain of the heterotrimeric G proteins. Members of the Ras superfamily regulate a wide variety of cellular functions: the Ras family regulates gene expression, the Rho family regulates cytoskeletal reorganization and gene expression, the Rab and Sar1/Arf families regulate vesicle trafficking, and the Ran family regulates nucleocytoplasmic transport and microtubule organization. The GTP translation factor family regulates initiation, elongation, termination, and release in translation, and the Era-like GTPase family regulates cell division, sporulation, and DNA replication. Members of the Ras superfamily are identified by the GTP binding site, which is made up of five characteristic sequence motifs, and the switch I and switch II regions.


Pssm-ID: 206648 [Multi-domain]  Cd Length: 161  Bit Score: 47.84  E-value: 2.70e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059011 480 LLGRSGAGKSATGNTILGRSaFFSQLRAQPVTSSSQSGKRTLDWQ--DVVVVDTPSFIqtpgtEKDPSRLKEEIHHCLSL 557
Cdd:cd00882   2 VVGRGGVGKSSLLNALLGGE-VGEVSDVPGTTRDPDVYVKELDKGkvKLVLVDTPGLD-----EFGGLGREELARLLLRG 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059011 558 CEegmkIFVLVLQLGRFTQEDEVVVEQLEASFEENImkYMIVLFTrKEDLGDGDLHDYtnntkNKALKKILKKCNGRVCA 637
Cdd:cd00882  76 AD----LILLVVDSTDRESEEDAKLLILRRLRKEGI--PIILVGN-KIDLLEEREVEE-----LLRLEELAKILGVPVFE 143


                ....*
gi 47059011 638 FNNKE 642
Cdd:cd00882 144 VSAKT 148
Ras_like_GTPase cd00882
Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like ...
 288-400 3.87e-06

Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras, Rho, Rab, and Sar1/Arf families. This superfamily also includes proteins like the GTP translation factors, Era-like GTPases, and G-alpha chain of the heterotrimeric G proteins. Members of the Ras superfamily regulate a wide variety of cellular functions: the Ras family regulates gene expression, the Rho family regulates cytoskeletal reorganization and gene expression, the Rab and Sar1/Arf families regulate vesicle trafficking, and the Ran family regulates nucleocytoplasmic transport and microtubule organization. The GTP translation factor family regulates initiation, elongation, termination, and release in translation, and the Era-like GTPase family regulates cell division, sporulation, and DNA replication. Members of the Ras superfamily are identified by the GTP binding site, which is made up of five characteristic sequence motifs, and the switch I and switch II regions.


Pssm-ID: 206648 [Multi-domain]  Cd Length: 161  Bit Score: 47.45  E-value: 3.87e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059011 288 LLMGKRGVGKSAAGNSILGKQVFKTqfSEKQRVTKAFASHSRVWQ--GKKVLIIDSPEISSW-KLDESAVKNHTFPGPHA 364
Cdd:cd00882   1 VVVGRGGVGKSSLLNALLGGEVGEV--SDVPGTTRDPDVYVKELDkgKVKLVLVDTPGLDEFgGLGREELARLLLRGADL 78

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 47059011 365 FLLVTPlGSSLKSDDDVFSIIKRIFGEKFTKFTIVL 400
Cdd:cd00882  79 ILLVVD-STDRESEEDAKLLILRRLRKEGIPIILVG 113
Toc34_like cd01853
Translocon at the Outer-envelope membrane of Chloroplasts 34-like (Toc34-like); The Toc34-like ...
 476-602 1.32e-05

Translocon at the Outer-envelope membrane of Chloroplasts 34-like (Toc34-like); The Toc34-like (Translocon at the Outer-envelope membrane of Chloroplasts) family contains several Toc proteins, including Toc34, Toc33, Toc120, Toc159, Toc86, Toc125, and Toc90. The Toc complex at the outer envelope membrane of chloroplasts is a molecular machine of ~500 kDa that contains a single Toc159 protein, four Toc75 molecules, and four or five copies of Toc34. Toc64 and Toc12 are associated with the translocon, but do not appear to be part of the core complex. The Toc translocon initiates the import of nuclear-encoded preproteins from the cytosol into the organelle. Toc34 and Toc159 are both GTPases, while Toc75 is a beta-barrel integral membrane protein. Toc159 is equally distributed between a soluble cytoplasmic form and a membrane-inserted form, suggesting that assembly of the Toc complex is dynamic. Toc34 and Toc75 act sequentially to mediate docking and insertion of Toc159 resulting in assembly of the functional translocon.


Pssm-ID: 206652  Cd Length: 248  Bit Score: 47.31  E-value: 1.32e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059011 476 LNIILLGRSGAGKSATGNTILGR-----SAFfsqlraQPVTSSSQSGKRTLDWQDVVVVDTPSFIQTPGTEKDpSRLKEE 550
Cdd:cd01853  32 LTILVLGKTGVGKSSTINSIFGErkvsvSAF------QSETLRPREVSRTVDGFKLNIIDTPGLLESQDQRVN-RKILSI 104

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 47059011 551 IHHCLSLCEEGMKIFVLVLQLGRFTQEDEVVVEQLEASFEENIMKYMIVLFT 602
Cdd:cd01853 105 IKRFLKKKTIDVVLYVDRLDMYRVDNLDVPLLRAITDSFGPSIWRNAIVVLT 156
3a0901s04IAP86 TIGR00993
chloroplast protein import component Toc86/159, G and M domains; The long precursor of the 86K ...
 476-532 7.34e-05

chloroplast protein import component Toc86/159, G and M domains; The long precursor of the 86K protein originally described is proposed to have three domains. The N-terminal A-domain is acidic, repetitive, weakly conserved, readily removed by proteolysis during chloroplast isolation, and not required for protein translocation. The other domains are designated G (GTPase) and M (membrane anchor); this family includes most of the G domain and all of M. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273381 [Multi-domain]  Cd Length: 763  Bit Score: 46.10  E-value: 7.34e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 47059011   476 LNIILLGRSGAGKSATGNTILGRSAfFSQLRAQPVTSSSQSGKRTLDWQDVVVVDTP 532
Cdd:TIGR00993 119 LNILVLGKSGVGKSATINSIFGEVK-FSTDAFGMGTTSVQEIEGLVQGVKIRVIDTP 174
small_GTP TIGR00231
small GTP-binding protein domain; Proteins with a small GTP-binding domain recognized by this ...
 284-427 6.57e-04

small GTP-binding protein domain; Proteins with a small GTP-binding domain recognized by this model include Ras, RhoA, Rab11, translation elongation factor G, translation initiation factor IF-2, tetratcycline resistance protein TetM, CDC42, Era, ADP-ribosylation factors, tdhF, and many others. In some proteins the domain occurs more than once.This model recognizes a large number of small GTP-binding proteins and related domains in larger proteins. Note that the alpha chains of heterotrimeric G proteins are larger proteins in which the NKXD motif is separated from the GxxxxGK[ST] motif (P-loop) by a long insert and are not easily detected by this model. [Unknown function, General]


Pssm-ID: 272973 [Multi-domain]  Cd Length: 162  Bit Score: 40.82  E-value: 6.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059011   284 ELRVLLMGKRGVGKSAAGNSILGKQVFKTqfSEKQRVTKAFASHSRVWQGKKVL--IIDSPEISswklDESAVKNHTFPG 361
Cdd:TIGR00231   1 DIKIVIVGHPNVGKSTLLNSLLGNKGSIT--EYYPGTTRNYVTTVIEEDGKTYKfnLLDTAGQE----DYDAIRRLYYPQ 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 47059011   362 PHAFLLVTPLGSSLKS-DDDVFSIIKRIFGEKFTKFTIVLFTRKEDFEDQALD-KVIKENDALYNLTQ 427
Cdd:TIGR00231  75 VERSLRVFDIVILVLDvEEILEKQTKEIIHHADSGVPIILVGNKIDLKDADLKtHVASEFAKLNGEPI 142
3a0901s02IAP34 TIGR00991
GTP-binding protein (Chloroplast Envelope Protein Translocase); [Transport and binding ...
 281-342 1.16e-03

GTP-binding protein (Chloroplast Envelope Protein Translocase); [Transport and binding proteins, Nucleosides, purines and pyrimidines]


Pssm-ID: 130064  Cd Length: 313  Bit Score: 41.42  E-value: 1.16e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 47059011   281 DMPELRVLLMGKRGVGKSAAGNSILGKQVFKTQFSEKQRVTKAFASHSRvwQGKKVLIIDSP 342
Cdd:TIGR00991  35 DVSSLTILVMGKGGVGKSSTVNSIIGERIATVSAFQSEGLRPMMVSRTR--AGFTLNIIDTP 94
MMR_HSR1 pfam01926
50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete ...
 477-603 1.70e-03

50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete activity of the protein of interacting with the 50S ribosome and binding of both adenine and guanine nucleotides, with a preference for guanine nucleotide.


Pssm-ID: 460387 [Multi-domain]  Cd Length: 113  Bit Score: 38.75  E-value: 1.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059011   477 NIILLGRSGAGKSATGNTILGRSAFFSqlrAQP-VTSSSQSGKRTLDWQDVVVVDTPSFIQTPGTEKDPSRLKEEIHHCl 555
Cdd:pfam01926   1 RVALVGRPNVGKSTLINALTGAKAIVS---DYPgTTRDPNEGRLELKGKQIILVDTPGLIEGASEGEGLGRAFLAIIEA- 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 47059011   556 slceegmKIFVLVLQ-LGRFTQEDEVVVEQLeasfeENIMKYMIVLFTR 603
Cdd:pfam01926  77 -------DLILFVVDsEEGITPLDEELLELL-----RENKKPIILVLNK 113
YeeP COG3596
Predicted GTPase [General function prediction only];
283-370 6.95e-03

Predicted GTPase [General function prediction only];


Pssm-ID: 442815 [Multi-domain]  Cd Length: 318  Bit Score: 38.98  E-value: 6.95e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059011 283 PELRVLLMGKRGVGKSAAGNSILGKQVFKTqfSEKQRVTKAFASHsrVWQ---GKKVLIIDSP---EISSWKLDESAVKN 356
Cdd:COG3596  38 PPPVIALVGKTGAGKSSLINALFGAEVAEV--GVGRPCTREIQRY--RLEsdgLPGLVLLDTPglgEVNERDREYRELRE 113

                        90
                ....*....|....
gi 47059011 357 HTfPGPHAFLLVTP 370
Cdd:COG3596 114 LL-PEADLILWVVK 126
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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