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Conserved domains on  [gi|46047420|ref|NP_996764|]
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amphoterin-induced protein 1 precursor [Rattus norvegicus]

Protein Classification

LRR and IG_like domain-containing protein( domain architecture ID 11471650)

LRR and IG_like domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
66-224 1.77e-24

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 105.40  E-value: 1.77e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46047420  66 LDLSHNNLSRLKAEwtPTRLTNLHSLLLSHNHLNFISSEaFVPVPNLRYLDLSSNHLHTLDEFLfSGLQALEVLLLYNNH 145
Cdd:COG4886 118 LDLSGNQLTDLPEE--LANLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDLPEEL-GNLTNLKELDLSNNQ 193

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46047420 146 IVVVDrNAFEDMAQLQKLYLSQNMISRFPLELikdaNRLPKLTLLDLSSNKLKKLP-LTDLQKLpawvkNGLYLHNNPLE 224
Cdd:COG4886 194 ITDLP-EPLGNLTNLEELDLSGNQLTDLPEPL----ANLTNLETLDLSNNQLTDLPeLGNLTNL-----EELDLSNNQLT 263
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 279-358 1.33e-08

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


:

Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 52.12  E-value: 1.33e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46047420    279 EAHLGDTLTITCDTKQQGMTKV-WVTPSNEQVLNqgaNGTVTVSEDGN---LHFKEVQVEDGGVYTCYAMGETFNETLSV 354
Cdd:smart00410   5 TVKEGESVTLSCEASGSPPPEVtWYKQGGKLLAE---SGRFSVSRSGStstLTISNVTPEDSGTYTCAATNSSGSASSGT 81


                   ....
gi 46047420    355 ELKV 358
Cdd:smart00410  82 TLTV 85
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
66-224 1.77e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 105.40  E-value: 1.77e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46047420  66 LDLSHNNLSRLKAEwtPTRLTNLHSLLLSHNHLNFISSEaFVPVPNLRYLDLSSNHLHTLDEFLfSGLQALEVLLLYNNH 145
Cdd:COG4886 118 LDLSGNQLTDLPEE--LANLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDLPEEL-GNLTNLKELDLSNNQ 193

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46047420 146 IVVVDrNAFEDMAQLQKLYLSQNMISRFPLELikdaNRLPKLTLLDLSSNKLKKLP-LTDLQKLpawvkNGLYLHNNPLE 224
Cdd:COG4886 194 ITDLP-EPLGNLTNLEELDLSGNQLTDLPEPL----ANLTNLETLDLSNNQLTDLPeLGNLTNL-----EELDLSNNQLT 263
LRR_8 pfam13855
Leucine rich repeat;
110-170 4.63e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 66.78  E-value: 4.63e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 46047420   110 PNLRYLDLSSNHLHTLDEFLFSGLQALEVLLLYNNHIVVVDRNAFEDMAQLQKLYLSQNMI 170
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
31-213 5.21e-14

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 74.73  E-value: 5.21e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46047420   31 VVSCPANCLCASNILSCSKQQLPNVPQSLPGYTALLDLSHNNLSRLkaewtPTRL-TNLHSLLLSHNHLNFISSEafvpV 109
Cdd:PRK15370 211 LKSLPENLQGNIKTLYANSNQLTSIPATLPDTIQEMELSINRITEL-----PERLpSALQSLDLFHNKISCLPEN----L 281

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46047420  110 PN-LRYLDLSSNHLHTLDEFLFSG----------LQALEVLLLYNNHIVVVDRNAFEDM-----AQLQKLYLSQNMISRF 173
Cdd:PRK15370 282 PEeLRYLSVYDNSIRTLPAHLPSGithlnvqsnsLTALPETLPPGLKTLEAGENALTSLpaslpPELQVLDVSKNQITVL 361

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 46047420  174 PLELIkdanrlPKLTLLDLSSNKLKKLPltdlQKLPAWVK 213
Cdd:PRK15370 362 PETLP------PTITTLDVSRNALTNLP----ENLPAALQ 391
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 279-358 1.33e-08

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 52.12  E-value: 1.33e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46047420    279 EAHLGDTLTITCDTKQQGMTKV-WVTPSNEQVLNqgaNGTVTVSEDGN---LHFKEVQVEDGGVYTCYAMGETFNETLSV 354
Cdd:smart00410   5 TVKEGESVTLSCEASGSPPPEVtWYKQGGKLLAE---SGRFSVSRSGStstLTISNVTPEDSGTYTCAATNSSGSASSGT 81


                   ....
gi 46047420    355 ELKV 358
Cdd:smart00410  82 TLTV 85
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 83-238 2.33e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 51.33  E-value: 2.33e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46047420  83 TRLTNLHsllLSHNHLNFIssEAFVPVPNLRYLDLSSNHLHTLDEFlfSGLQALEVLLLYNNHIVVVDRnaFEDMAQLQK 162
Cdd:cd21340   2 KRITHLY---LNDKNITKI--DNLSLCKNLKVLYLYDNKITKIENL--EFLTNLTHLYLQNNQIEKIEN--LENLVNLKK 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46047420 163 LYLSQNMISR--------FPLELIKDANRLPK-----------------LTLLDLSSNKLKKlpLTDLQKLPAWVKngLY 217
Cdd:cd21340  73 LYLGGNRISVveglenltNLEELHIENQRLPPgekltfdprslaalsnsLRVLNISGNNIDS--LEPLAPLRNLEQ--LD 148

                       170       180
                ....*....|....*....|.
gi 46047420 218 LHNNPLECDCKLYQLFSHWQY 238
Cdd:cd21340 149 ASNNQISDLEELLDLLSSWPS 169
I-set pfam07679
Immunoglobulin I-set domain;
279-358 1.77e-05

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 43.40  E-value: 1.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46047420   279 EAHLGDTLTITCDTKQQGMTKV-WVtpSNEQVLNQGANGTVTVSED-GNLHFKEVQVEDGGVYTCYAMGETFNETLSVEL 356
Cdd:pfam07679  11 EVQEGESARFTCTVTGTPDPEVsWF--KDGQPLRSSDRFKVTYEGGtYTLTISNVQPDDSGKYTCVATNSAGEAEASAEL 88


                  ..
gi 46047420   357 KV 358
Cdd:pfam07679  89 TV 90
IgI_Lingo-1 cd20969
Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing ...
 283-358 1.67e-04

Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1); The members here are composed of the immunoglobulin I-set (IgI) domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1). Human Lingo-1 is a central nervous system-specific transmembrane glycoprotein also known as LERN-1, which functions as a negative regulator of neuronal survival, axonal regeneration, and oligodendrocyte differentiation and myelination. Lingo-1 is a key component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. The ligand-binding ectodomain of human Lingo-1 contains a bimodular, kinked structure composed of leucine-rich repeat (LRR) and immunoglobulin (Ig)-like modules. Diseases associated with Lingo-1 include mental retardation, autosomal recessive 64 and essential tremor. The Ig superfamily (IgSF) is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Unlike the V-set, one of the distinctive features of I-set domains is the lack of a C" strand. The structure of the Lingo-1 lacks this strand and thus it belongs to the I-set of the IgSF. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.


Pssm-ID: 409561  Cd Length: 92  Bit Score: 40.45  E-value: 1.67e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 46047420 283 GDTLTITCdtKQQGM---TKVWVTPsNEQVLNQGANGTVTVSEDGNLHFKEVQVEDGGVYTCYAMGETFNETLSVELKV 358
Cdd:cd20969  17 GHTVQFVC--RADGDpppAILWLSP-RKHLVSAKSNGRLTVFPDGTLEVRYAQVQDNGTYLCIAANAGGNDSMPAHLHV 92
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
66-224 1.77e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 105.40  E-value: 1.77e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46047420  66 LDLSHNNLSRLKAEwtPTRLTNLHSLLLSHNHLNFISSEaFVPVPNLRYLDLSSNHLHTLDEFLfSGLQALEVLLLYNNH 145
Cdd:COG4886 118 LDLSGNQLTDLPEE--LANLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDLPEEL-GNLTNLKELDLSNNQ 193

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46047420 146 IVVVDrNAFEDMAQLQKLYLSQNMISRFPLELikdaNRLPKLTLLDLSSNKLKKLP-LTDLQKLpawvkNGLYLHNNPLE 224
Cdd:COG4886 194 ITDLP-EPLGNLTNLEELDLSGNQLTDLPEPL----ANLTNLETLDLSNNQLTDLPeLGNLTNL-----EELDLSNNQLT 263
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
44-235 5.85e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 100.78  E-value: 5.85e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46047420  44 ILSCSKQQLPNVPQSLPGYTAL--LDLSHNNLSRLKAEWTPtrLTNLHSLLLSHNHLNFISsEAFVPVPNLRYLDLSSNH 121
Cdd:COG4886 140 ELDLSNNQLTDLPEPLGNLTNLksLDLSNNQLTDLPEELGN--LTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQ 216

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46047420 122 LHTLDEFLfSGLQALEVLLLYNNHIVVVDrnAFEDMAQLQKLYLSQNMISRFPLELikdanRLPKLTLLDLSSNKLKKLP 201
Cdd:COG4886 217 LTDLPEPL-ANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLA-----NLTNLKTLDLSNNQLTDLK 288

                       170       180       190
                ....*....|....*....|....*....|....
gi 46047420 202 LTDLQKLPAWVKNGLYLHNNPLECDCKLYQLFSH 235
Cdd:COG4886 289 LKELELLLGLNSLLLLLLLLNLLELLILLLLLTT 322
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
43-224 2.46e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 93.07  E-value: 2.46e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46047420  43 NILSCSKQQLPNVPQSLPGYTALLDLSHNNLSRLKAEWTPTRLTNLHSLLLSHNHLNFIsSEAFVPVPNLRYLDLSSNHL 122
Cdd:COG4886  70 SLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQL 148

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46047420 123 HTLDEFLfSGLQALEVLLLYNNHIVVVDrNAFEDMAQLQKLYLSQNMISRFPLELikdaNRLPKLTLLDLSSNKLKKLP- 201
Cdd:COG4886 149 TDLPEPL-GNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDLPEPL----GNLTNLEELDLSGNQLTDLPe 222

                       170       180
                ....*....|....*....|....
gi 46047420 202 -LTDLQKLpawvkNGLYLHNNPLE 224
Cdd:COG4886 223 pLANLTNL-----ETLDLSNNQLT 241
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
45-247 2.38e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.21  E-value: 2.38e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46047420  45 LSCSKQQLPNVPQSLPGYTAL--LDLSHNNLSRLKAEWTptRLTNLHSLLLSHNHLNFISSEaFVPVPNLRYLDLSSNHL 122
Cdd:COG4886 164 LDLSNNQLTDLPEELGNLTNLkeLDLSNNQITDLPEPLG--NLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQL 240

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46047420 123 HTLDEFlfSGLQALEVLLLYNNHIVVVDRNAfeDMAQLQKLYLSQNMISRFPLELIKDANRLPKLTLLDLSSNKLKKLPL 202
Cdd:COG4886 241 TDLPEL--GNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLIL 316

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 46047420 203 TDLQKLPAWVKNGLYLHNNPLECDCKLYQLFSHWQYRQLSSVMDF 247
Cdd:COG4886 317 LLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSL 361
LRR_8 pfam13855
Leucine rich repeat;
110-170 4.63e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 66.78  E-value: 4.63e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 46047420   110 PNLRYLDLSSNHLHTLDEFLFSGLQALEVLLLYNNHIVVVDRNAFEDMAQLQKLYLSQNMI 170
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
31-213 5.21e-14

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 74.73  E-value: 5.21e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46047420   31 VVSCPANCLCASNILSCSKQQLPNVPQSLPGYTALLDLSHNNLSRLkaewtPTRL-TNLHSLLLSHNHLNFISSEafvpV 109
Cdd:PRK15370 211 LKSLPENLQGNIKTLYANSNQLTSIPATLPDTIQEMELSINRITEL-----PERLpSALQSLDLFHNKISCLPEN----L 281

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46047420  110 PN-LRYLDLSSNHLHTLDEFLFSG----------LQALEVLLLYNNHIVVVDRNAFEDM-----AQLQKLYLSQNMISRF 173
Cdd:PRK15370 282 PEeLRYLSVYDNSIRTLPAHLPSGithlnvqsnsLTALPETLPPGLKTLEAGENALTSLpaslpPELQVLDVSKNQITVL 361

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 46047420  174 PLELIkdanrlPKLTLLDLSSNKLKKLPltdlQKLPAWVK 213
Cdd:PRK15370 362 PETLP------PTITTLDVSRNALTNLP----ENLPAALQ 391
LRR_8 pfam13855
Leucine rich repeat;
86-146 1.99e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 62.16  E-value: 1.99e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 46047420    86 TNLHSLLLSHNHLNFISSEAFVPVPNLRYLDLSSNHLHTLDEFLFSGLQALEVLLLYNNHI 146
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
66-122 3.42e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 58.30  E-value: 3.42e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 46047420    66 LDLSHNNLSRLKAEWtPTRLTNLHSLLLSHNHLNFISSEAFVPVPNLRYLDLSSNHL 122
Cdd:pfam13855   6 LDLSNNRLTSLDDGA-FKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
136-197 1.81e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.68  E-value: 1.81e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 46047420   136 LEVLLLYNNHIVVVDRNAFEDMAQLQKLYLSQNMISRFPLELIKDanrLPKLTLLDLSSNKL 197
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSG---LPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 55-201 8.44e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 58.32  E-value: 8.44e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46047420   55 VPQSLPGYTAL--LDLSHNNLSrlkAEWTPT--RLTNLHSLLLSHNHLNFISSEAFVPVPNLRYLDLSSNHLHTLDEFLF 130
Cdd:PLN00113 228 IPYEIGGLTSLnhLDLVYNNLT---GPIPSSlgNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPELV 304

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 46047420  131 SGLQALEVLLLYNNHIVVVDRNAFEDMAQLQKLYLSQNmisRFPLELIKDANRLPKLTLLDLSSNKLK-KLP 201
Cdd:PLN00113 305 IQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSN---KFSGEIPKNLGKHNNLTVLDLSTNNLTgEIP 373
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 279-358 1.33e-08

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 52.12  E-value: 1.33e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46047420    279 EAHLGDTLTITCDTKQQGMTKV-WVTPSNEQVLNqgaNGTVTVSEDGN---LHFKEVQVEDGGVYTCYAMGETFNETLSV 354
Cdd:smart00410   5 TVKEGESVTLSCEASGSPPPEVtWYKQGGKLLAE---SGRFSVSRSGStstLTISNVTPEDSGTYTCAATNSSGSASSGT 81


                   ....
gi 46047420    355 ELKV 358
Cdd:smart00410  82 TLTV 85
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 83-238 2.33e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 51.33  E-value: 2.33e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46047420  83 TRLTNLHsllLSHNHLNFIssEAFVPVPNLRYLDLSSNHLHTLDEFlfSGLQALEVLLLYNNHIVVVDRnaFEDMAQLQK 162
Cdd:cd21340   2 KRITHLY---LNDKNITKI--DNLSLCKNLKVLYLYDNKITKIENL--EFLTNLTHLYLQNNQIEKIEN--LENLVNLKK 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46047420 163 LYLSQNMISR--------FPLELIKDANRLPK-----------------LTLLDLSSNKLKKlpLTDLQKLPAWVKngLY 217
Cdd:cd21340  73 LYLGGNRISVveglenltNLEELHIENQRLPPgekltfdprslaalsnsLRVLNISGNNIDS--LEPLAPLRNLEQ--LD 148

                       170       180
                ....*....|....*....|.
gi 46047420 218 LHNNPLECDCKLYQLFSHWQY 238
Cdd:cd21340 149 ASNNQISDLEELLDLLSSWPS 169
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 64-198 1.17e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 50.43  E-value: 1.17e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46047420  64 ALLDLSHNNLS----RLKAEWTPTRLTNLHSLLLSHNHLNFISSEA----FVPVPNLRYLDLSSNHL-HTLDEFLFSGL- 133
Cdd:cd00116 111 QELKLNNNGLGdrglRLLAKGLKDLPPALEKLVLGRNRLEGASCEAlakaLRANRDLKELNLANNGIgDAGIRALAEGLk 190

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 46047420 134 --QALEVLLLYNNHI----VVVDRNAFEDMAQLQKLYLSQNMISRFPLELIKDANRLPKLTL--LDLSSNKLK 198
Cdd:cd00116 191 anCNLEVLDLNNNGLtdegASALAETLASLKSLEVLNLGDNNLTDAGAAALASALLSPNISLltLSLSCNDIT 263
I-set pfam07679
Immunoglobulin I-set domain;
279-358 1.77e-05

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 43.40  E-value: 1.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46047420   279 EAHLGDTLTITCDTKQQGMTKV-WVtpSNEQVLNQGANGTVTVSED-GNLHFKEVQVEDGGVYTCYAMGETFNETLSVEL 356
Cdd:pfam07679  11 EVQEGESARFTCTVTGTPDPEVsWF--KDGQPLRSSDRFKVTYEGGtYTLTISNVQPDDSGKYTCVATNSAGEAEASAEL 88


                  ..
gi 46047420   357 KV 358
Cdd:pfam07679  89 TV 90
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 279-343 2.74e-05

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 42.55  E-value: 2.74e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 46047420   279 EAHLGDTLTITCDTKQQGMTKVWVTPSNEQVLNQGANGTVTVSEDGNLHFKEVQVEDGGVYTCYA 343
Cdd:pfam13927  12 TVREGETVTLTCEATGSPPPTITWYKNGEPISSGSTRSRSLSGSNSTLTISNVTRSDAGTYTCVA 76
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 66-197 6.09e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 45.55  E-value: 6.09e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46047420  66 LDLSHNNLSRLKAEWTPTRL---TNLHSLLLSHNHLNFISSEAFVP----VPNLRYLDLSSNHLHTLD-EFLFSGLQA-- 135
Cdd:COG5238 269 LYLSGNQIGAEGAIALAKALqgnTTLTSLDLSVNRIGDEGAIALAEglqgNKTLHTLNLAYNGIGAQGaIALAKALQEnt 348

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 46047420 136 -LEVLLLYNNHI----VVVDRNAFEDMAQLQKLYLSQNMISRFPLELIKDANRLPKLTLLDLSSNKL 197
Cdd:COG5238 349 tLHSLDLSDNQIgdegAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQTNRLHTLILDGNLI 415
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 66-174 6.24e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.39  E-value: 6.24e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46047420  66 LDLSHNNLSRLKA-EwtptRLTNLHSLLLSHNHLNfiSSEAFVPVPN--------LRYLDLSSNHLHTLDEflFSGLQAL 136
Cdd:cd21340  73 LYLGGNRISVVEGlE----NLTNLEELHIENQRLP--PGEKLTFDPRslaalsnsLRVLNISGNNIDSLEP--LAPLRNL 144

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 46047420 137 EVLLLYNNHIVVVDR--NAFEDMAQLQKLYLSQNMISRFP 174
Cdd:cd21340 145 EQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKP 184
IgI_Lingo-1 cd20969
Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing ...
 283-358 1.67e-04

Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1); The members here are composed of the immunoglobulin I-set (IgI) domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1). Human Lingo-1 is a central nervous system-specific transmembrane glycoprotein also known as LERN-1, which functions as a negative regulator of neuronal survival, axonal regeneration, and oligodendrocyte differentiation and myelination. Lingo-1 is a key component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. The ligand-binding ectodomain of human Lingo-1 contains a bimodular, kinked structure composed of leucine-rich repeat (LRR) and immunoglobulin (Ig)-like modules. Diseases associated with Lingo-1 include mental retardation, autosomal recessive 64 and essential tremor. The Ig superfamily (IgSF) is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Unlike the V-set, one of the distinctive features of I-set domains is the lack of a C" strand. The structure of the Lingo-1 lacks this strand and thus it belongs to the I-set of the IgSF. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.


Pssm-ID: 409561  Cd Length: 92  Bit Score: 40.45  E-value: 1.67e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 46047420 283 GDTLTITCdtKQQGM---TKVWVTPsNEQVLNQGANGTVTVSEDGNLHFKEVQVEDGGVYTCYAMGETFNETLSVELKV 358
Cdd:cd20969  17 GHTVQFVC--RADGDpppAILWLSP-RKHLVSAKSNGRLTVFPDGTLEVRYAQVQDNGTYLCIAANAGGNDSMPAHLHV 92
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 286-343 2.38e-04

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 39.62  E-value: 2.38e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 46047420 286 LTITCDTKQQGMTKVWVTPSNEQVLNQGANGTVTVSEDGNLHFKEVQVEDGGVYTCYA 343
Cdd:cd00096   1 VTLTCSASGNPPPTITWYKNGKPLPPSSRDSRRSELGNGTLTISNVTLEDSGTYTCVA 58
LRR_8 pfam13855
Leucine rich repeat;
159-223 3.40e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.66  E-value: 3.40e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 46047420   159 QLQKLYLSQNMISRFPLELIKDanrLPKLTLLDLSSNKLKKLPLTDLQKLPAWVKngLYLHNNPL 223
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKG---LSNLKVLDLSNNLLTTLSPGAFSGLPSLRY--LDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 55-197 6.55e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.53  E-value: 6.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46047420   55 VPQSLPGYTAL--LDLSHNNLS-RLKAEWTPTRLTNLhsLLLSHNHLNFISSEAFVPVPNLRYLDLSSNhlhtldEFL-- 129
Cdd:PLN00113 396 IPKSLGACRSLrrVRLQDNSFSgELPSEFTKLPLVYF--LDISNNNLQGRINSRKWDMPSLQMLSLARN------KFFgg 467

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 46047420  130 ---FSGLQALEVLLLYNNHIVVVDRNAFEDMAQLQKLYLSQNMIS-RFPLELikdaNRLPKLTLLDLSSNKL 197
Cdd:PLN00113 468 lpdSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSgEIPDEL----SSCKKLVSLDLSHNQL 535
LRR_9 pfam14580
Leucine-rich repeat;
115-208 9.17e-04

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 40.13  E-value: 9.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46047420   115 LDLSSNHLHTLDEFLFsgLQALEVLLLYNNHIVVVDRNAFEDMAQLQKLYLSQNMISRfpLELIKDANRLPKLTLLDLSS 194
Cdd:pfam14580  47 IDFSDNEIRKLDGFPL--LRRLKTLLLNNNRICRIGEGLGEALPNLTELILTNNNLQE--LGDLDPLASLKKLTFLSLLR 122

                          90       100
                  ....*....|....*....|....*...
gi 46047420   195 N--------------KLKKLPLTDLQKL 208
Cdd:pfam14580 123 NpvtnkphyrlyviyKVPQLRLLDFRKV 150
IgI_4_Robo cd05726
Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of ...
 282-344 1.32e-03

Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains; Members here are composed the fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors. Robo receptors play a role in the development of the central nervous system (CNS), and are receptors of Slit protein. Slit is a repellant secreted by the neural cells in the midline. Slit acts through Robo to prevent most neurons from crossing the midline from either side. Three mammalian Robo homologs (Robo1, Robo2, Robo3), and three mammalian Slit homologs (Slit-1, Slit-2, Slit-3), have been identified. Commissural axons, which cross the midline, express low levels of Robo; longitudinal axons, which avoid the midline, express high levels of Robo. Robo1, Robo2, and Robo3 are expressed by commissural neurons in the vertebrate spinal cord and Slit-1, Slit-2, and Slit-3 are expressed at the ventral midline. Robo-3 is a divergent member of the Robo family which instead of being a positive regulator of Slit responsiveness, antagonizes Slit responsiveness in precrossing axons. The Slit-Robo interaction is mediated by the second leucine-rich repeat (LRR) domain of Slit and the two N-terminal Ig domains of Robo, Ig1 and Ig2. The primary Robo binding site for Slit2 has been shown by surface plasmon resonance experiments and mutational analysis to be the Ig1 domain, while the Ig2 domain has been proposed to harbor a weak secondary binding site. This group belongs to the I-set of IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409391 [Multi-domain]  Cd Length: 98  Bit Score: 38.01  E-value: 1.32e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 46047420 282 LGDTLTITCDTKQQGMTKVWVTPSNEQVL-----NQGANGTVTVSEDGNLHFKEVQVEDGGVYTCYAM 344
Cdd:cd05726  13 LGRTVTFQCETKGNPQPAIFWQKEGSQNLlfpyqPPQPSSRFSVSPTGDLTITNVQRSDVGYYICQAL 80
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 283-358 1.88e-03

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 36.99  E-value: 1.88e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 46047420   283 GDTLTITCDTKQQGMTKV-WVTPSNEqvlnqgangtvtVSEDGNLHFKEVQVEDGGVYTCYA-MGETFNETLSVELKV 358
Cdd:pfam13895  14 GEPVTLTCSAPGNPPPSYtWYKDGSA------------ISSSPNFFTLSVSAEDSGTYTCVArNGRGGKVSNPVELTV 79
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 49-198 2.87e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 40.16  E-value: 2.87e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46047420  49 KQQLPNVPQSLPGYTAL--LDLSHNNLSRLKAEWTPTRL---TNLHSLLLSHNHLN---FIS-SEAFVPVPNLRYLDLSS 119
Cdd:COG5238 222 DEGAEILAEALKGNKSLttLDLSNNQIGDEGVIALAEALknnTTVETLYLSGNQIGaegAIAlAKALQGNTTLTSLDLSV 301

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46047420 120 NHLHtldeflFSGLQALeVLLLYNNHIVVVdrnafedmaqlqkLYLSQNMISRFPLE-LIKDANRLPKLTLLDLSSNKLK 198
Cdd:COG5238 302 NRIG------DEGAIAL-AEGLQGNKTLHT-------------LNLAYNGIGAQGAIaLAKALQENTTLHSLDLSDNQIG 361
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 110-146 3.24e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 35.30  E-value: 3.24e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 46047420   110 PNLRYLDLSSNHLHTLDefLFSGLQALEVL-LLYNNHI 146
Cdd:pfam12799   1 PNLEVLDLSNNQITDIP--PLAKLPNLETLdLSGNNKI 36
IgV_HHLA2 cd16091
Immunoglobulin Variable (IgV) domain in HERV-H LTR-associating 2 (HHLA2); The members here are ...
 324-358 3.64e-03

Immunoglobulin Variable (IgV) domain in HERV-H LTR-associating 2 (HHLA2); The members here are composed of the immunoglobulin variable (IgV) region in HERV-H LTR-associating 2 (HHLA2; also known as B7-H7/B7 homolog 7). HHLA2 is a member of the B7 family of immune regulatory proteins. Mature human HHLA2 consists of an extracellular domain (ECD) with three immunoglobulin-like domains, a transmembrane segment, and a cytoplasmic domain. HHLA2 is widely expressed in human cancers including non-small cell lung carcinoma (NSCLS), triple negative breast cancer (TNBC), and melanoma, but has limited expression on normal tissues. Interestingly, unlike other members of B7 family, HHLA2 is not expressed in mice or rats. HHLA2 functions as a T cell coinhibitory molecules as it inhibits the proliferation of activated CD4(+) and CD8(+) T cells and their cytokine production. Furthermore, HHLA2 is constitutively expressed on the surface of human monocytes and is induced on B cells after stimulation, however it is not inducible on T cells.


Pssm-ID: 409512  Cd Length: 107  Bit Score: 36.98  E-value: 3.64e-03
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 46047420 324 GN--LHFKEVQVEDGGVYTCYAMGETFNETLSVELKV 358
Cdd:cd16091  71 GNasLLLRRVQLQDEGRYKCYTSTIIGNQESFVNLKV 107
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
44-224 3.93e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 39.53  E-value: 3.93e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46047420  44 ILSCSKQQLPNVPqSLPGYTAL--LDLSHNNLSRLKAEwtpTRLTNLHSLLLSHNHLNFISSEAFVPVPNLRYLDLSSNH 121
Cdd:COG4886 232 TLDLSNNQLTDLP-ELGNLTNLeeLDLSNNQLTDLPPL---ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLL 307

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46047420 122 LHTLDEFL-FSGLQALEVLLLYNNHIVVVDRNAFEDMAQLQKLYLSQNMISRFPLELIKDANRLPKLTLLDLSSNKLKKL 200
Cdd:COG4886 308 LNLLELLIlLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLL 387

                       170       180
                ....*....|....*....|....
gi 46047420 201 PLTDLQKLPAWVKNGLYLHNNPLE 224
Cdd:COG4886 388 TLLLLLLTTTAGVLLLTLALLDAV 411
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 86-128 5.35e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.91  E-value: 5.35e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 46047420    86 TNLHSLLLSHNHLNFIssEAFVPVPNLRYLDLSSN-HLHTLDEF 128
Cdd:pfam12799   1 PNLEVLDLSNNQITDI--PPLAKLPNLETLDLSGNnKITDLSDL 42
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 159-209 5.91e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.91  E-value: 5.91e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 46047420   159 QLQKLYLSQNMISRFPLElikdaNRLPKLTLLDLSSNKlkklPLTDLQKLP 209
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPL-----AKLPNLETLDLSGNN----KITDLSDLA 43
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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