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Conserved domains on  [gi|48762515|ref|NP_995316|]
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GDNF family receptor alpha-like precursor [Mus musculus]

Protein Classification

GDNF family receptor alpha( domain architecture ID 10492245)

glial cell line-derived neurotrophic factor (GDNF) family receptor alpha is a glycosylphosphatidylinositol-linked cell surface receptor for GDNF; similar to Homo sapiens GDNF family receptor alpha-4

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 131-210 1.50e-13

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


:

Pssm-ID: 460537  Cd Length: 87  Bit Score: 65.63  E-value: 1.50e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762515   131 CLEVTEACVGDVVCNAQLALYLKACSANGNLCD----VKHCQAAIRFFYQNMPFNTAQMLAFCDCAQS---DIPCQQSKE 203
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADFQSNCQPSPESCSgcpnPARCLRAYRMTPNYVDNLGTSLLLWCTCKGSgnqDEECEEFRR 80


                  ....*..
gi 48762515   204 TLHSKPC 210
Cdd:pfam02351  81 NFTVNSC 87
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 220-316 1.35e-11

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


:

Pssm-ID: 460537  Cd Length: 87  Bit Score: 60.24  E-value: 1.35e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762515   220 CLSVIHTCRNDELCRTHYRTFQTECWPHItGKCHedetcismlgkqdlTCSGSESCRAAFLGTF------GTVLQVPCAC 293
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADFQSNCQPSP-ESCS--------------GCPNPARCLRAYRMTPnyvdnlGTSLLLWCTC 65

                          90       100
                  ....*....|....*....|...
gi 48762515   294 RGVTQAEEHvCMIFQHMLHSKSC 316
Cdd:pfam02351  66 KGSGNQDEE-CEEFRRNFTVNSC 87
 
Name Accession Description Interval E-value
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 131-210 1.50e-13

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 460537  Cd Length: 87  Bit Score: 65.63  E-value: 1.50e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762515   131 CLEVTEACVGDVVCNAQLALYLKACSANGNLCD----VKHCQAAIRFFYQNMPFNTAQMLAFCDCAQS---DIPCQQSKE 203
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADFQSNCQPSPESCSgcpnPARCLRAYRMTPNYVDNLGTSLLLWCTCKGSgnqDEECEEFRR 80


                  ....*..
gi 48762515   204 TLHSKPC 210
Cdd:pfam02351  81 NFTVNSC 87
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 220-316 1.35e-11

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 460537  Cd Length: 87  Bit Score: 60.24  E-value: 1.35e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762515   220 CLSVIHTCRNDELCRTHYRTFQTECWPHItGKCHedetcismlgkqdlTCSGSESCRAAFLGTF------GTVLQVPCAC 293
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADFQSNCQPSP-ESCS--------------GCPNPARCLRAYRMTPnyvdnlGTSLLLWCTC 65

                          90       100
                  ....*....|....*....|...
gi 48762515   294 RGVTQAEEHvCMIFQHMLHSKSC 316
Cdd:pfam02351  66 KGSGNQDEE-CEEFRRNFTVNSC 87
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 220-316 3.65e-11

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 58.81  E-value: 3.65e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762515    220 CLSVIHTCRNDELCRTHYRTFQTECWPHITGKCHED--ETCISMLgkqdltcsGSESCRAAFLGTfgTVLQVPCACRGvt 297
Cdd:smart00907   1 CLEALKACELDPVCRSRLADYLSACSPSPSSSCPGEnsEACLRAY--------CGLALRPFYDDN--SSVLLFCTCAG-- 68

                           90
                   ....*....|....*....
gi 48762515    298 qAEEHVCMIFQHMLHSKSC 316
Cdd:smart00907  69 -NRDEECLEFRRLFHSNPC 86
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 131-210 5.45e-09

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 52.64  E-value: 5.45e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762515    131 CLEVTEACVGDVVCNAQLALYLKACSA---------NGNLCDVKHCQAAIRFFYQnmpfNTAQMLAFCDCA-QSDIPCQQ 200
Cdd:smart00907   1 CLEALKACELDPVCRSRLADYLSACSPspssscpgeNSEACLRAYCGLALRPFYD----DNSSVLLFCTCAgNRDEECLE 76

                           90
                   ....*....|
gi 48762515    201 SKETLHSKPC 210
Cdd:smart00907  77 FRRLFHSNPC 86
 
Name Accession Description Interval E-value
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 131-210 1.50e-13

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 460537  Cd Length: 87  Bit Score: 65.63  E-value: 1.50e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762515   131 CLEVTEACVGDVVCNAQLALYLKACSANGNLCD----VKHCQAAIRFFYQNMPFNTAQMLAFCDCAQS---DIPCQQSKE 203
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADFQSNCQPSPESCSgcpnPARCLRAYRMTPNYVDNLGTSLLLWCTCKGSgnqDEECEEFRR 80


                  ....*..
gi 48762515   204 TLHSKPC 210
Cdd:pfam02351  81 NFTVNSC 87
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 220-316 1.35e-11

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 460537  Cd Length: 87  Bit Score: 60.24  E-value: 1.35e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762515   220 CLSVIHTCRNDELCRTHYRTFQTECWPHItGKCHedetcismlgkqdlTCSGSESCRAAFLGTF------GTVLQVPCAC 293
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADFQSNCQPSP-ESCS--------------GCPNPARCLRAYRMTPnyvdnlGTSLLLWCTC 65

                          90       100
                  ....*....|....*....|...
gi 48762515   294 RGVTQAEEHvCMIFQHMLHSKSC 316
Cdd:pfam02351  66 KGSGNQDEE-CEEFRRNFTVNSC 87
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 220-316 3.65e-11

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 58.81  E-value: 3.65e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762515    220 CLSVIHTCRNDELCRTHYRTFQTECWPHITGKCHED--ETCISMLgkqdltcsGSESCRAAFLGTfgTVLQVPCACRGvt 297
Cdd:smart00907   1 CLEALKACELDPVCRSRLADYLSACSPSPSSSCPGEnsEACLRAY--------CGLALRPFYDDN--SSVLLFCTCAG-- 68

                           90
                   ....*....|....*....
gi 48762515    298 qAEEHVCMIFQHMLHSKSC 316
Cdd:smart00907  69 -NRDEECLEFRRLFHSNPC 86
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 131-210 5.45e-09

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 52.64  E-value: 5.45e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762515    131 CLEVTEACVGDVVCNAQLALYLKACSA---------NGNLCDVKHCQAAIRFFYQnmpfNTAQMLAFCDCA-QSDIPCQQ 200
Cdd:smart00907   1 CLEALKACELDPVCRSRLADYLSACSPspssscpgeNSEACLRAYCGLALRPFYD----DNSSVLLFCTCAgNRDEECLE 76

                           90
                   ....*....|
gi 48762515    201 SKETLHSKPC 210
Cdd:smart00907  77 FRRLFHSNPC 86
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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