BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45); ZBTB45, also called zinc finger protein 499 (ZNF499), may act as a transcriptional regulator that is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387819  16 SSQSVLEALRSQRRKGLFCDVTVRIHDASLRAHACVLAAGSPFFQDKLLLGHSEISVPPLVPAETVRQLVDFMYSGSLVV 95
Cdd:cd18229   1 FSKSLLETLNAQRLGGHFCDVTVRIHDASLRAHRCVLAAGSPFFHDKLLLGHSEIEVPPVVPAQTVRQLVEFMYSGSLVV 80

                        90       100       110
                ....*....|....*....|....*....|..
gi 45387819  96 LHSQALCILTAASILQIKTVIDECTQIISQRR 127
Cdd:cd18229  81 AQSEALQILTAASILQIKTVIDECTQIISQSR 112

Zinc-finger double domain;

                          10        20
                  ....*....|....*....|....*.
gi 45387819   527 SLNVHMRTHRVERTFTCAVCHRAFTH 552
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45); ZBTB45, also called zinc finger protein 499 (ZNF499), may act as a transcriptional regulator that is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387819  16 SSQSVLEALRSQRRKGLFCDVTVRIHDASLRAHACVLAAGSPFFQDKLLLGHSEISVPPLVPAETVRQLVDFMYSGSLVV 95
Cdd:cd18229   1 FSKSLLETLNAQRLGGHFCDVTVRIHDASLRAHRCVLAAGSPFFHDKLLLGHSEIEVPPVVPAQTVRQLVEFMYSGSLVV 80

                        90       100       110
                ....*....|....*....|....*....|..
gi 45387819  96 LHSQALCILTAASILQIKTVIDECTQIISQRR 127
Cdd:cd18229  81 AQSEALQILTAASILQIKTVIDECTQIISQSR 112

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387819     35 DVTVRIHDASLRAHACVLAAGSPFFQDKLLLG-----HSEISVPPlVPAETVRQLVDFMYSGSLVVLHSQALCILTAASI 109
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDfkesdKSEIYLDD-VSPEDFRALLNFLYTGKLDLPEENVEELLELADY 79

                           90
                   ....*....|....*...
gi 45387819    110 LQIKTVIDECTQIISQRR 127
Cdd:smart00225  80 LQIPGLVELCEEFLLKLL 97

Zinc-finger double domain;

                          10        20
                  ....*....|....*....|....*.
gi 45387819   527 SLNVHMRTHRVERTFTCAVCHRAFTH 552
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26

Zinc-finger double domain;

                          10        20
                  ....*....|....*....|....*.
gi 45387819   499 YLLKHMVVHTGVRAFQCSVCSKRFTQ 524
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26

kelch-like protein; Provisional

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387819   33 FCDVTVRIH--DASLRAHACVLAAGSPFFqDKLLLGHS---EISVPplVPAETVRQLVDFMYSGSLVVLHSQALCILTAA 107
Cdd:PHA03098   9 FCDESIIIVngGGIIKVHKIILSSSSEYF-KKMFKNNFkenEINLN--IDYDSFNEVIKYIYTGKINITSNNVKDILSIA 85

                         90
                 ....*....|....*.
gi 45387819  108 SILQIKTVIDECTQII 123
Cdd:PHA03098  86 NYLIIDFLINLCINYI 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45); ZBTB45, also called zinc finger protein 499 (ZNF499), may act as a transcriptional regulator that is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387819  16 SSQSVLEALRSQRRKGLFCDVTVRIHDASLRAHACVLAAGSPFFQDKLLLGHSEISVPPLVPAETVRQLVDFMYSGSLVV 95
Cdd:cd18229   1 FSKSLLETLNAQRLGGHFCDVTVRIHDASLRAHRCVLAAGSPFFHDKLLLGHSEIEVPPVVPAQTVRQLVEFMYSGSLVV 80

                        90       100       110
                ....*....|....*....|....*....|..
gi 45387819  96 LHSQALCILTAASILQIKTVIDECTQIISQRR 127
Cdd:cd18229  81 AQSEALQILTAASILQIKTVIDECTQIISQSR 112

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387819    24 LRSQRRKGLFCDVTVRIHDASLRAHACVLAAGSPFFQDKLLLGHSEISVP----PLVPAETVRQLVDFMYSGSLvVLHSQ 99
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSeitlDDVSPEDFEALLEFMYTGKL-ISEEN 79

                          90       100
                  ....*....|....*....|....*.
gi 45387819   100 ALCILTAASILQIKTVIDECTQIISQ 125
Cdd:pfam00651  80 VDDLLAAADKLQIPSLVDKCEEFLIK 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387819  17 SQSVLEALRSQRRKGLFCDVTVRIHDASLRAHACVLAAGSPFFQDKLLLGHSE-ISVPPLVPAETVRQLVDFMYSGSLVV 95
Cdd:cd18200   2 SSALLETLNKHRLEGKFCDLSVHVQGRVFRAHKAVLAASSPYFHDKLLLNDTNcLVLPSVIEAAAFENLLQLIYSGRLTL 81

                        90       100       110
                ....*....|....*....|....*....|
gi 45387819  96 LHSQALCILTAASILQIKTVIDECTQIISQ 125
Cdd:cd18200  82 CMDALPSHLLVASGLQMWQVVDRCSELLKE 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387819  33 FCDVTVRIHDASLRAHACVLAAGSPFFQDKLLLGHSEISVPPL----VPAETVRQLVDFMYSGSLVVLHSQALCILTAAS 108
Cdd:cd18186   1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSSSEIelddVSPEAFEALLDYIYTGELELSEENVEELLAAAD 80

                ..
gi 45387819 109 IL 110
Cdd:cd18186  81 KL 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 26 (ZBTB26); ZBTB26, also called zinc finger protein 481 (ZNF481) or zinc finger protein Bioref, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387819  13 LQNSSQSVLEALRSQRRKGLFCDVTVRIHDASLRAHACVLAAGSPFFQDKLLLGHS-EISVPPLVPAETVRQLVDFMYSG 91
Cdd:cd18214   5 FENYGDSMLQKMNKLREQNKFCDVTVHIDDLEVPGHKVVFAAGSPFLRDQFLLNDSrEVQISILQNSEVGRQLLLSCYTG 84

                        90       100       110
                ....*....|....*....|....*....|....
gi 45387819  92 SLVVLHSQALCILTAASILQIKTVIDECTQIISQ 125
Cdd:cd18214  85 VLEFPEMELVNYLTAASFLQMSHIVERCTQALWK 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 6 (ZBTB6); ZBTB6, also called zinc finger protein 482 (ZNF482) or zinc finger protein with interaction domain, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387819  11 IHLQNSSQ--SVLEALRSQRRKGLFCDVTVRIHDASLRAHACVLAAGSPFFQDKLLLGHS-EISVPPLVPAETVRQLVDF 87
Cdd:cd18197   1 LHFKFEQQgdAVLQKMNLLRQQNLFCDVSIYINDTEFHGHKVILAACSTFMRDQFLLNQSkQVRITILQSAEVGRKLLLS 80

                        90       100       110
                ....*....|....*....|....*....|....
gi 45387819  88 MYSGSLVVLHSQALCILTAASILQIKTVIDECTQ 121
Cdd:cd18197  81 CYTGALEVKKKELLKYLTAASYLQMVHIVEKCTE 114

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387819     35 DVTVRIHDASLRAHACVLAAGSPFFQDKLLLG-----HSEISVPPlVPAETVRQLVDFMYSGSLVVLHSQALCILTAASI 109
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDfkesdKSEIYLDD-VSPEDFRALLNFLYTGKLDLPEENVEELLELADY 79

                           90
                   ....*....|....*...
gi 45387819    110 LQIKTVIDECTQIISQRR 127
Cdd:smart00225  80 LQIPGLVELCEEFLLKLL 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387819  20 VLEALRSQRRKGLFCDVTVRIHDASLRAHACVLAAGSPFFQDKLLLGHSE------ISVPPLVPAETVRQLVDFMYSGSL 93
Cdd:cd18201   8 LLQELNEQRKKGILCDVNIVVSGKVFRAHKNILVAGSRFFKTLYCFTNKEscdqttVTHLDVVAVQGFSVILDFMYSGNL 87

                        90       100       110
                ....*....|....*....|....*....|
gi 45387819  94 VVLHSQALCILTAASILQIKTVIDECTQII 123
Cdd:cd18201  88 VLTSQNAIEVMSVASYLQMTEVVQSCRNFI 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387819  21 LEALRSQRRKGLFCDVTVRIHDASLRAHACVLAAGSPFFQDKLLL-----GHSEISVPPLVPAETVRQLVDFMYSGSLVV 95
Cdd:cd18293   3 FLQLHRQQNSGVFCDVLLQAEGESVPAHCCVLSACSPYLTERLSSepppaGQKVVLELQGLKAHTLLKLVDFLYTSELEV 82

                        90
                ....*....|....*..
gi 45387819  96 LHSQALCILTAASILQI 112
Cdd:cd18293  83 SSEEAQDVLAAARRLQI 99

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387819  17 SQSVLEALRSQRRKGLFCDVTVRIHDASLRAHACVLAAGSPFFQ-------DK--LLLGHSEIsvpplVPAETVRQLVDF 87
Cdd:cd18323   7 SRHLLQSLREQRHQGFLCDCTVLVGSTQFLAHRAVLASCSPFFHmfykeqlDKrdLVCINNEI-----VTAPAFSLLLEF 81

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 45387819  88 MYSGSLVVLHSQALCILTAASILQIKTVIDECTQIISQR 126
Cdd:cd18323  82 MYEGRLSFNDTPVEDVLAAASYLHMNDIVKVCKKRLQAR 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387819  12 HLQNSSQSVLEALRsqrRKGLFCDVTVRIHDASLRAHACVLAAGSPFFQ-----DKLLLGHSEISVPPLVPaETVRQLVD 86
Cdd:cd18247   1 DLPSSGFPVMEEIR---RQGKLCDVTLKVGDQKFSAHRIVLAATIPYFHamfthDMVESKQDEITMQGIEP-SALEALIN 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 45387819  87 FMYSGSLVVLHSQALCILTAASILQIKTVIDECTQIISQR 126
Cdd:cd18247  77 FAYSGRIAIDTSNVQSLLVGASFLQLQSVKDACCEFLKER 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387819  11 IHLQNSSQSVLEALRSQRRKGLFCDVTVRIHDASLRAHACVLAAGSPFFQdKLLLGHSEISVPPL-----VPAETVRQLV 85
Cdd:cd18328   3 IPFPNHSSEVLCSLNEQRHDGLLCDVVLIVQDQEYRTHRSVLAACSKYFK-KLFTAGTLADQPYVyeidfVTPEALSAIL 81

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 45387819  86 DFMYSGSLVVLHSQALCILTAASILQIKTVIDECTQII 123
Cdd:cd18328  82 EFAYTSTLTITTSNVKHILNAAQMLEIQCIINVCLEIM 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387819  17 SQSVLEALRSQRRKGLFCDVTVRIHDASLRAHACVLAAGSPFFQ-------DK--LLLGHSEISVPPlvpaeTVRQLVDF 87
Cdd:cd18194   7 SRQLLQCLREQRSQGFLCDCTVLVGSAQFPAHRAVLASCSMYFHlfyrdrlDKrdLVRLNSDIVTAP-----AFGLLLDF 81

                        90       100       110
                ....*....|....*....|....*....|..
gi 45387819  88 MYSGSLVVLHSQALCILTAASILQIKTVIDEC 119
Cdd:cd18194  82 MYEGRLALRDLPVEDVLAAASYLHMYDIVKVC 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387819  13 LQNSSQSVLEALRSQRRKGLFCDVTVRIHDASLRAHACVLAAGSPFFQdKLLLGHSEISV-PPLVPAETVRQLVDFMYSG 91
Cdd:cd18334   1 LPNHAKQLLLQLNQQRAKGFLCDVIIVVENALFRAHKNILAASSMYFK-SLVLHDNLINLdTDMVNPTVFRQILDFIYTG 79

                        90       100       110
                ....*....|....*....|....*....|..
gi 45387819  92 SLVVLHSQA----LCILTAASILQIKTVIDEC 119
Cdd:cd18334  80 KLLTSDQPGeqnfNALLTAASYLQLHDLAALC 111

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387819  33 FCDVTVRIHDASLRAHACVLAAGSPFFQ----DKLLLGHSEISVPPlVPAETVRQLVDFMYSGSLVVLHSQALCILTAAS 108
Cdd:cd18315   1 LVDVTLACEGGSLKAHKLVLAAASPYFAallkETPPDEHPVIILPD-VPYSELKALLDFIYTGEVNVSQEQLESLLKLAE 79

                ....*
gi 45387819 109 ILQIK 113
Cdd:cd18315  80 LLQIK 84

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387819  17 SQSVLEALRSQRRKGLFCDVTVRIHDASLRAHACVLAAGSPFFQ-----------DKLLLGHSEISVPPLVPAETVRQLV 85
Cdd:cd18327   9 SSELLSCLNEQRRAGLLCDLTIKTRGLEYRTHRAVLAACSLYFRklftgggggsgDLGAGGGQDVCELDFVGPEALGALL 88

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 45387819  86 DFMYSGSLVVLHSQALCILTAASILQIKTVIDECTQII 123
Cdd:cd18327  89 EFAYTATLTISSSNMREVLRAARLLEIPCVADACADIL 126

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387819   7 AVHYIHLqnssqsvLEALRSQRRKGLFCDVTVRIHDASLRAHACVLAAGSPFFQDKLLLGHSEISVPPLV-----PAETV 81
Cdd:cd18329   2 SSHQSRL-------LQQLDEQRKQELFCDCSILVEGQVFKAHRNVLFASSGYFKMLLSQNAKETGQPTVAtfdvfSPDTF 74

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 45387819  82 RQLVDFMYSGSLVVLHSQALCILTAASILQIKTVIDECTQII 123
Cdd:cd18329  75 TIILDFVYSGKLSLTSQNVIEVMSAASYLQMTDVISVCKTFI 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387819  21 LEALRSQRRKGLFCDVTVRIHDASLRAHACVLAAGSPFFQDKLLLGHSEiSVPPLVP-----AETVRQLVDFMYSGSLVV 95
Cdd:cd18238   3 FKVLHQFYENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTSEMAE-SKQDSITikdidEEAVELLVDFAYTGKLTL 81

                        90       100
                ....*....|....*....|....*....
gi 45387819  96 LHSQALCILTAASILQIKTVIDECTQIIS 124
Cdd:cd18238  82 TVDNVQSLLYAASLLQVEEVAKACCEFMK 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387819  20 VLEALRSQrrkGLFCDVTVRIHDASLRAHACVLAAGSPFFQDKLLLGHSEISVPPL----VPAETVRQLVDFMYSGSLVV 95
Cdd:cd18338  11 VMNELRSQ---NLLCDVTIVAEDVEIAAHRVVLAACSPYFHAMFTGEMSESRAKRVrikeVDGWTLKMLIDYVYTAEIQV 87

                        90       100       110
                ....*....|....*....|....*....|.
gi 45387819  96 LHSQALCILTAASILQIKTVIDECTQ-IISQ 125
Cdd:cd18338  88 TEENVQVLLPAAGLLQLQDVKKTCCEfLESQ 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387819  17 SQSVLEALRSQRRKGLFCDVTVRIHDASLRAHACVLAAGSPFFQDKLL----LGHSEISVPPLVPAETVRQLVDFMYSGS 92
Cdd:cd18332   3 SSDVLLNLNELRKRDILTDVTLLVGGTPLRAHKAVLIACSGFFYSIFSgrvgEGVSVLTLPSGLEARGFQLLLDFMYTSR 82

                        90       100       110
                ....*....|....*....|....*....|.
gi 45387819  93 LVVLHSQALCILTAASILQIKTVIDECTQII 123
Cdd:cd18332  83 LPLTPRTVPAVLAAATYLQMEHVVETCRRFI 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387819  17 SQSVLEALRSQRRKGLFCDVTVRIHDASLRAHACVLAAGSPFF------QDKLLLGHSeISVPPLvPAETVRQLVDFMYS 90
Cdd:cd18223   2 SDTVLSCLNEQRIQGILCDVTIVVEDTKFKAHKNVLAASSLYFknafssQEIWISSHV-LELPDL-KAEVFAEILNFIYS 79

                        90
                ....*....|....*..
gi 45387819  91 GSLVVLHSQALCILTAA 107
Cdd:cd18223  80 SKVVVKRQETVTDLVAA 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387819  20 VLEALRSQRrkgLFCDVTVRIHDASLRAHACVLAAGSPFFQDKLLLGHSEISVPPL----VPAETVRQLVDFMYSGSLVV 95
Cdd:cd18339  11 VMNELRSKQ---LLCDVTIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIeikdVDGQTLSKLIDYIYTAEIEV 87

                        90       100
                ....*....|....*....|....
gi 45387819  96 LHSQALCILTAASILQIKTVIDEC 119
Cdd:cd18339  88 TEENVQVLLPAASLLQLMDVRQNC 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387819  17 SQSVLEALRSQRRKGLFCDVTVRIHDASLRAHACVLAAGSPFFQdKLLLGH---SEISVPPL--VPAETVRQLVDFMYSG 91
Cdd:cd18265   7 AERILQVLNAYRRSGTFTDVVLLVDGKDFPCHRATLSANSAYFR-AMFGGHlkeSRQAVVEIqkVSAAAMEVLLDYMYGG 85

                        90       100       110
                ....*....|....*....|....*....|....*
gi 45387819  92 SLVVLHSQALCILTAASILQIKTVIDECTQIISQR 126
Cdd:cd18265  86 GLRIQEDNVESVLEASDLLQVSKLREACVRFLEGQ 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387819  19 SVLEALRSQRRKGLFCDVTVRIHDASLRAHACVLAAGSPFFQDKLL----LGHSEISVP-------------PLVPAETV 81
Cdd:cd18195   4 ALLLQLNEQRLRGLFCDVTLIAGDTKFRAHRSVLAASSPYFRELLSsplpLGAAAVAAApgatqspervlelPGVKAGVF 83