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Conserved domains on  [gi|186511048|ref|NP_974431|]
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Major facilitator superfamily protein [Arabidopsis thaliana]

Protein Classification

NRT1/PTR family MFS transporter( domain architecture ID 13024499)

NRT1/PTR (nitrate transporter/peptide transporter) family major facilitator superfamily (MFS) transporter is a proton-coupled transporter that facilitates the transport of one or more from a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA)

CATH:  1.20.1250.20
Gene Ontology:  GO:0016020|GO:0055085|GO:0022857
SCOP:  3000310
TCDB:  2.A.17

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MFS_NPF5 cd17417
NRT1/PTR family (NPF), subfamily 5 of the Major Facilitator Superfamily of transporters; The ...
16-541 0e+00

NRT1/PTR family (NPF), subfamily 5 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF5 includes Arabidopsis thaliana PTR3 (AtPTR3, now named AtNPF5.2), which is a wound-induced peptide transporter that is necessary for defense against virulent bacterial pathogens. NPF5 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340975 [Multi-domain]  Cd Length: 452  Bit Score: 649.71  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048  16 WNAALFIIVVEIAERFAFYGLASNLITFLTNELGQSTATAAKNINTWIGVSCMFPILGAFLADSILGRFKTVLLTSFIYL 95
Cdd:cd17417    1 WKACSFIIGIEVAERFAYYGIASNLVTYLTTPLHQSTARAAKNVNNWSGTATLLPLLGAFVADAYLGRYRTILISSLIYL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048  96 LGIVMLPLSVTVVARR-------------MREKVFFMALYVMAVGEGGHKPCVMTFAADQFGEANAEEKAAKTSFFNYWY 162
Cdd:cd17417   81 LGLVLLTLSASLPSLKppecngtcskastLQVAFFFFSLYLVAIGQGGHKPCVQAFGADQFDEDDPKEKKQKSSFFNWWY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 163 MAIVLASSIAVLALIFIQERVSWSLGFSIIAGSVVIAIVIFLIGIPKYRKQVpvgspftrvaqvmvaalkkwrlsstrhh 242
Cdd:cd17417  161 FSICAGSLTAVTVLVYIQDNVGWALGFGIPTIVMALALFVFLLGTPLYRYKV---------------------------- 212
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 243 yglcyeeedehklestnsnqvyllartnqfrfldkatiideidhnknrnpwrlctvnqvEEVKLILRLIPIWISLIMFCA 322
Cdd:cd17417  213 -----------------------------------------------------------EEVKLVLRLIPIWFTTLVFTV 233
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 323 TLTQLNTFFLKQGSMMDRTIGNHFTIPPAAFQSIVGVTILILIPLYDRVFVPMVRKITNHHSGITSLQRIGVGLFVATFN 402
Cdd:cd17417  234 VFAQSPTFFTKQGVTMDRTIGPNFKIPPASLQSFITLSILISIPIYDRVFVPIARKITGNPRGITLLQRIGIGMFLSILA 313
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 403 MVICGLVEAKRLKVARDHGLIdSPKEVVPMSSLWLLPQYILVGIGDVFTIVGMQELFYDQMPETMRSIGAAIFISVVGVG 482
Cdd:cd17417  314 MVIAALVEMKRLKVAKEHGLI-SPKATVPMSIFWLLPQYILLGIADVFTMVGMQEFFYDQVPDEMRSLGTALYLSVFGVG 392
                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 483 SFVSTGIISTVQTISKSHGE-EWLVNNLNRAHLDYYYWIIASLNAVSLCFYLFIANHFLY 541
Cdd:cd17417  393 SFLSSFLISIVDKITSSSGGqSWFNNNLNRAHLDYFYWLLAVLSAVNFVLFLFVAKSYVY 452
 
Name Accession Description Interval E-value
MFS_NPF5 cd17417
NRT1/PTR family (NPF), subfamily 5 of the Major Facilitator Superfamily of transporters; The ...
16-541 0e+00

NRT1/PTR family (NPF), subfamily 5 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF5 includes Arabidopsis thaliana PTR3 (AtPTR3, now named AtNPF5.2), which is a wound-induced peptide transporter that is necessary for defense against virulent bacterial pathogens. NPF5 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340975 [Multi-domain]  Cd Length: 452  Bit Score: 649.71  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048  16 WNAALFIIVVEIAERFAFYGLASNLITFLTNELGQSTATAAKNINTWIGVSCMFPILGAFLADSILGRFKTVLLTSFIYL 95
Cdd:cd17417    1 WKACSFIIGIEVAERFAYYGIASNLVTYLTTPLHQSTARAAKNVNNWSGTATLLPLLGAFVADAYLGRYRTILISSLIYL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048  96 LGIVMLPLSVTVVARR-------------MREKVFFMALYVMAVGEGGHKPCVMTFAADQFGEANAEEKAAKTSFFNYWY 162
Cdd:cd17417   81 LGLVLLTLSASLPSLKppecngtcskastLQVAFFFFSLYLVAIGQGGHKPCVQAFGADQFDEDDPKEKKQKSSFFNWWY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 163 MAIVLASSIAVLALIFIQERVSWSLGFSIIAGSVVIAIVIFLIGIPKYRKQVpvgspftrvaqvmvaalkkwrlsstrhh 242
Cdd:cd17417  161 FSICAGSLTAVTVLVYIQDNVGWALGFGIPTIVMALALFVFLLGTPLYRYKV---------------------------- 212
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 243 yglcyeeedehklestnsnqvyllartnqfrfldkatiideidhnknrnpwrlctvnqvEEVKLILRLIPIWISLIMFCA 322
Cdd:cd17417  213 -----------------------------------------------------------EEVKLVLRLIPIWFTTLVFTV 233
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 323 TLTQLNTFFLKQGSMMDRTIGNHFTIPPAAFQSIVGVTILILIPLYDRVFVPMVRKITNHHSGITSLQRIGVGLFVATFN 402
Cdd:cd17417  234 VFAQSPTFFTKQGVTMDRTIGPNFKIPPASLQSFITLSILISIPIYDRVFVPIARKITGNPRGITLLQRIGIGMFLSILA 313
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 403 MVICGLVEAKRLKVARDHGLIdSPKEVVPMSSLWLLPQYILVGIGDVFTIVGMQELFYDQMPETMRSIGAAIFISVVGVG 482
Cdd:cd17417  314 MVIAALVEMKRLKVAKEHGLI-SPKATVPMSIFWLLPQYILLGIADVFTMVGMQEFFYDQVPDEMRSLGTALYLSVFGVG 392
                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 483 SFVSTGIISTVQTISKSHGE-EWLVNNLNRAHLDYYYWIIASLNAVSLCFYLFIANHFLY 541
Cdd:cd17417  393 SFLSSFLISIVDKITSSSGGqSWFNNNLNRAHLDYFYWLLAVLSAVNFVLFLFVAKSYVY 452
PTR2 pfam00854
POT family; The POT (proton-dependent oligopeptide transport) family all appear to be proton ...
84-502 3.38e-88

POT family; The POT (proton-dependent oligopeptide transport) family all appear to be proton dependent transporters.


Pssm-ID: 425909 [Multi-domain]  Cd Length: 392  Bit Score: 277.28  E-value: 3.38e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048   84 FKTVLLTSFIYLLGIVMLPLSVT-VVARRMREKVFFMALYVMAVGEGGHKPCVMTFAADQFGEANAEEKaakTSFFNYWY 162
Cdd:pfam00854   1 FRTIFLGSIIYAIGHILLALSAIpSLRPPVHVALFFIGLALIALGTGGIKPNVSSFGGDQFEETDPRRR---SRFFSIFY 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048  163 MAIVLASSIAVLALIFIQERVSWSLGFSIIAGSVVIAIVIFLIGIPKYRKQVPVGSPFTRVAQVMVAALKKwRLSSTRHH 242
Cdd:pfam00854  78 FSINAGSLISTIITPYLQQNYGYPLGFGLPAVGMIIALLVFLLGSRMYKKKPPKGNVLTKVFKVLPVAAWN-KVKLNGSS 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048  243 YGLCYEEEDEHklestnsnqvyllartnqFRFLDKATIIDEIDHNKNRNPWrlCTVNQVEEVKLILRLIPIWISLIMFCA 322
Cdd:pfam00854 157 AGIKKLHWLDW------------------ARELDALIILGIVVPGIFFNIW--CTKTKVEEVKRLLRVLPLFLPLIMFWA 216
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048  323 TLTQLNTFFLKQGSMMDRTIGnHFTIPPAAFQSIVGVTILILIPLYDRVFVPMVRKITNhhsGITSLQRIGVGLFVATFN 402
Cdd:pfam00854 217 LYDQMGTSWVLQARTMNRKIG-SFEIPPAQFQAFNAILVLIFIPIFDRLVYPLGRKCTG---GLTPLQKMAVGLFLASLA 292
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048  403 MVICGLVEAKRLKVARDHGlidsPKEVVPMSSLWLLPQYILVGIGDVFTIVGMQELFYDQMPETMRSIGAAIFISVVGVG 482
Cdd:pfam00854 293 FAIAAIVQLKRNDTGPEFP----IAQEVPISVLWLIPQYLLIGFGELFISIGGLEFFYKLAPKSMTSLITGLFLLTNALG 368
                         410       420
                  ....*....|....*....|
gi 186511048  483 SFVSTGIISTVQTISKSHGE 502
Cdd:pfam00854 369 NFLSGVIATLTAKPTNVLGA 388
2A1704 TIGR00926
Peptide:H+ symporter (also transports b-lactam antibiotics, the antitumor agent, bestatin, and ...
31-415 2.63e-35

Peptide:H+ symporter (also transports b-lactam antibiotics, the antitumor agent, bestatin, and various protease inhibitors); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273343 [Multi-domain]  Cd Length: 654  Bit Score: 140.67  E-value: 2.63e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048   31 FAFYGLASNLITFLTNELGQSTATAAKNINTWIGVSCMFPILGAFLADSILGRFKTVLLTSFIYLLGIVMLPL-SVTVVA 109
Cdd:TIGR00926   1 FSYYGMRTILVLYFLNFLGFSESTSTVLFHTFTYLCYLTPLIGAIIADGWLGKFKTILYLSIVYVVGHALLSFgAIPSSG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048  110 RRMREKVFFMALYVMAVGEGGHKPCVMTFAADQFGEANAEekaAKTSFFNYWYMAIVLASSIAVLALIFIQERVS----- 184
Cdd:TIGR00926  81 HPLHDLLDLLGLALIALGTGGIKPCVSAFGGDQFEERQLS---LRSRFFSFFYFAINAGSLISTIITPILRGDVGcfgcq 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048  185 --WSLGFSIIAGSVVIAIVIFLIGIPKYRKQVPVGSPFTRVAQVMVAALKKWrlSSTRHhyglcyEEEDEHKLESTnsnq 262
Cdd:TIGR00926 158 dcYPLAFGVPAILMILALIVFMAGSKMYKKKPPKGNIVSKVIKCIVTALRKR--FSTRS------EHWPLHWLDYA---- 225
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048  263 vyllartnqfrfLDKATIIDeidhnknrnpwrlctvnqVEEVKLILRLIPIWISLIMFCATLTQLNTFFLKQGSMMDRTI 342
Cdd:TIGR00926 226 ------------KDKHDIRM------------------IRSTKRLLRVLVLFIPLPMFWALFDQQGSRWTLQATRMDGDV 275
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 186511048  343 GnHFTIPPAAFQSIVGVTILILIPLYDRVFVPMVRKITNHhsgITSLQRIGVGLFVATFNMVICGLVEAKRLK 415
Cdd:TIGR00926 276 G-GFEIQPDQMQVVNPLLILIFVPIFDYIVYPAIAKCGTR---FTSLRKMAVGGLLAALSFFVAALVQLKVNP 344
PTR2 COG3104
Dipeptide/tripeptide permease [Amino acid transport and metabolism];
21-492 6.61e-33

Dipeptide/tripeptide permease [Amino acid transport and metabolism];


Pssm-ID: 442338 [Multi-domain]  Cd Length: 479  Bit Score: 131.48  E-value: 6.61e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048  21 FIIVVEIAERFAFYGLASNLITFLTNEL-----GQSTATAAKNINTWIGVSCMFPILGAFLADSILGRFKTVLLTSFIYL 95
Cdd:COG3104   18 TLFFTEMWERFSFYGMRAILVLYLTASLadgglGLSEADAAAIYGAYTALVYLTPLLGGWLADRLLGQRRAILLGGILMA 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048  96 LGIVMLPLSVTVVArrmrekvFFMALYVMAVGEGGHKPCVMTFAADQFGEANAEEKAAktsfFNYWYMAIVLASSIAVLA 175
Cdd:COG3104   98 LGHFLLALPGGVTL-------FYLGLALIAVGNGLFKPNISSLVGQLYDPGDPRRDAG----FTIFYMGINIGAFLAPLL 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 176 LIFIQERVSWSLGFSIIAGSVVIAIVIFLIGIPKYR----KQVPVGSPFTRVAQVMVAALKKWRLSSTRHHYglcyeeed 251
Cdd:COG3104  167 CGYLGEKYGWHYGFGAAAIGMLIGLIIFLLGRKYLGdiglEPDNPLSKKERLIAVALGALLLVLVLAGLLSN-------- 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 252 ehklESTNSNQVYLLARTNQFRFLDKATIIDeidhnknrnpwrlctvnqVEEVKLILRLIPIWISLIMFCATLTQ----L 327
Cdd:COG3104  239 ----ANIANYLLYVIAIIAYFIFILRSKKLT------------------KEERKRLLAILILFLFSIVFWALYEQagtsL 296
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 328 NTFFLKqgsMMDRTIGNhFTIPPAAFQSIVGVTILILIPLYDRVFVPMVRKITNhhsgITSLQRIGVGLFVATFNMVICG 407
Cdd:COG3104  297 NLFADR---NVDRSLFG-FEIPPSWFQSLNPLFIIILAPVFAALWTKLGKRGKE----PSTPTKFALGLLLLGLGFLVMA 368
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 408 LVEakrlKVARDHGLIdspkevvpmSSLWLLPQYILVGIGDVFT-IVGMqELFYDQMPETMRSIGAAIFISVVGVGSFVS 486
Cdd:COG3104  369 LAA----LLAGAGGKV---------SPLWLVLAYLLLTIGELCLsPVGL-SMITKLAPARFAGQMMGLWFLATALGNLLA 434

                 ....*.
gi 186511048 487 tGIIST 492
Cdd:COG3104  435 -GLLAG 439
PRK15462 PRK15462
dipeptide permease;
18-206 3.33e-17

dipeptide permease;


Pssm-ID: 237971 [Multi-domain]  Cd Length: 493  Bit Score: 84.61  E-value: 3.33e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048  18 AALFIIVVEIAERFAFYGLASNLITFLTNELGQSTATAAKNINTWIGVSCMFPILGAFLADSILGRFKTVLLTSFIYLLG 97
Cdd:PRK15462  10 AIYYVVALQIWEYFSFYGMRALLILYLTNQLKYDDNHAYELFSAYCSLVYVTPILGGFLADKVLGNRMAVMLGALLMAIG 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048  98 IVMLPlsvtvvARRMREKVFFMALYVMAVGEGGHKPCVMTFaadqFGEANAEEKAAKTSFFNYWYMAIVLASSIAVLALI 177
Cdd:PRK15462  90 HVVLG------ASEIHPSFLYLSLAIIVCGYGLFKSNVSCL----LGELYEPTDPRRDGGFSLMYAAGNVGSIIAPIACG 159
                        170       180
                 ....*....|....*....|....*....
gi 186511048 178 FIQERVSWSLGFSIIAGSVVIAIVIFLIG 206
Cdd:PRK15462 160 YAQEEYSWAMGFGLAAVGMIAGLVIFLCG 188
 
Name Accession Description Interval E-value
MFS_NPF5 cd17417
NRT1/PTR family (NPF), subfamily 5 of the Major Facilitator Superfamily of transporters; The ...
16-541 0e+00

NRT1/PTR family (NPF), subfamily 5 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF5 includes Arabidopsis thaliana PTR3 (AtPTR3, now named AtNPF5.2), which is a wound-induced peptide transporter that is necessary for defense against virulent bacterial pathogens. NPF5 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340975 [Multi-domain]  Cd Length: 452  Bit Score: 649.71  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048  16 WNAALFIIVVEIAERFAFYGLASNLITFLTNELGQSTATAAKNINTWIGVSCMFPILGAFLADSILGRFKTVLLTSFIYL 95
Cdd:cd17417    1 WKACSFIIGIEVAERFAYYGIASNLVTYLTTPLHQSTARAAKNVNNWSGTATLLPLLGAFVADAYLGRYRTILISSLIYL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048  96 LGIVMLPLSVTVVARR-------------MREKVFFMALYVMAVGEGGHKPCVMTFAADQFGEANAEEKAAKTSFFNYWY 162
Cdd:cd17417   81 LGLVLLTLSASLPSLKppecngtcskastLQVAFFFFSLYLVAIGQGGHKPCVQAFGADQFDEDDPKEKKQKSSFFNWWY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 163 MAIVLASSIAVLALIFIQERVSWSLGFSIIAGSVVIAIVIFLIGIPKYRKQVpvgspftrvaqvmvaalkkwrlsstrhh 242
Cdd:cd17417  161 FSICAGSLTAVTVLVYIQDNVGWALGFGIPTIVMALALFVFLLGTPLYRYKV---------------------------- 212
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 243 yglcyeeedehklestnsnqvyllartnqfrfldkatiideidhnknrnpwrlctvnqvEEVKLILRLIPIWISLIMFCA 322
Cdd:cd17417  213 -----------------------------------------------------------EEVKLVLRLIPIWFTTLVFTV 233
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 323 TLTQLNTFFLKQGSMMDRTIGNHFTIPPAAFQSIVGVTILILIPLYDRVFVPMVRKITNHHSGITSLQRIGVGLFVATFN 402
Cdd:cd17417  234 VFAQSPTFFTKQGVTMDRTIGPNFKIPPASLQSFITLSILISIPIYDRVFVPIARKITGNPRGITLLQRIGIGMFLSILA 313
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 403 MVICGLVEAKRLKVARDHGLIdSPKEVVPMSSLWLLPQYILVGIGDVFTIVGMQELFYDQMPETMRSIGAAIFISVVGVG 482
Cdd:cd17417  314 MVIAALVEMKRLKVAKEHGLI-SPKATVPMSIFWLLPQYILLGIADVFTMVGMQEFFYDQVPDEMRSLGTALYLSVFGVG 392
                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 483 SFVSTGIISTVQTISKSHGE-EWLVNNLNRAHLDYYYWIIASLNAVSLCFYLFIANHFLY 541
Cdd:cd17417  393 SFLSSFLISIVDKITSSSGGqSWFNNNLNRAHLDYFYWLLAVLSAVNFVLFLFVAKSYVY 452
MFS_NPF cd17351
Plant NRT1/PTR family (NPF) of the Major Facilitator Superfamily of transporters; The plant ...
19-536 7.64e-165

Plant NRT1/PTR family (NPF) of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340909 [Multi-domain]  Cd Length: 445  Bit Score: 475.96  E-value: 7.64e-165
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048  19 ALFIIVVEIAERFAFYGLASNLITFLTNELGQSTATAAKNINTWIGVSCMFPILGAFLADSILGRFKTVLLTSFIYLLGI 98
Cdd:cd17351    1 APFILGNEFAERLAFYGIAVNLVTYLTKVMHLSNAKAANTVTNFSGTSYLTPLLGAFLADAYLGRYWTIAIFSVIYLVGL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048  99 VMLPLSVTV---------------VARRMREKVFFMALYVMAVGEGGHKPCVMTFAADQFGEANAEEKAAKTSFFNYWYM 163
Cdd:cd17351   81 ILLTLSASVpslrpppcnpdspcePASSTQLTVLYVGLYLIALGTGGIKPCVSAFGADQFDETDPKEKKQKPSFFNWFYF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 164 AIVLASSIAVLALIFIQERVSWSLGFSIIAGSVVIAIVIFLIGIPKYRkqvpvgspftrvaqvmvaalkkwrlsstrhhy 243
Cdd:cd17351  161 SINLGSLLAVTLVVYIQDNVSWGWGFGIPAAAMALAVIVFVAGTPFYR-------------------------------- 208
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 244 glcyeeedehklestnsnqvyllartnqfrfldkatiideidhnknrnpwrlctvnqveEVKLILRLIPIWISLIMFCAT 323
Cdd:cd17351  209 -----------------------------------------------------------EVKCLLRLLPIWATTILLSTV 229
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 324 LTQLNTFFLKQGSMMDRTIGNHFTIPPAAFQSIVGVTILILIPLYDRVFVPMVRKITNHHSGITSLQRIGVGLFVATFNM 403
Cdd:cd17351  230 YAQMQTFFVQQGLTMDRRLGGSFEIPAASLSVFSTLFVLLFIPLYDRVFVPFARRYTGNPRGITPLQRIGIGLVLSILAM 309
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 404 VICGLVEAKRLKVARDHGLIDSPKEVVPMSSLWLLPQYILVGIGDVFTIVGMQELFYDQMPETMRSIGAAIFISVVGVGS 483
Cdd:cd17351  310 AVAALVEVKRLRVARAHGLLDSPTGVVPMSVFWLLPQYFLLGLAEVFTYIGQLEFFYDEAPDGMRSLGTALFLLTIALGN 389
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....
gi 186511048 484 FVSTGIISTVQTIS-KSHGEEWLVNNLNRAHLDYYYWIIASLNAVSLCFYLFIA 536
Cdd:cd17351  390 FLSSALVTIVNKITgKGGGPGWLPNNLNKGRLDYFYWLLAVLSAVNFLVFLVCA 443
MFS_NPF7 cd17419
NRT1/PTR family (NPF), subfamily 7 of the Major Facilitator Superfamily of transporters; The ...
16-536 1.09e-138

NRT1/PTR family (NPF), subfamily 7 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF7 includes the nitrate transporters AtNPF7.2 and AtNPF7.3, as well as the dipeptide transporter OsNPF7.3. AtNPF7.3 is a bidirectional transporter involved in nitrate influx and efflux. NPF7 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340977 [Multi-domain]  Cd Length: 447  Bit Score: 409.07  E-value: 1.09e-138
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048  16 WNAALFIIVVEIAERFAFYGLASNLITFLTNELGQSTATAAKNINTWIGVSCMFPILGAFLADSILGRFKTVLLTSFIYL 95
Cdd:cd17419    1 WKSAIFILVNQGLATLAYFGVGVNLVLYLTRVMHQSNASAANNVSNWTGTVYITPLIGAFLSDSYWGRYWTSTLFQAIFV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048  96 LGIVMLPLSVTVV----------------ARRMREKVFFMALYVMAVGEGGHKPCVMTFAADQFGEANAEEKAAKTSFFN 159
Cdd:cd17419   81 IGLLLLTLSSALPslrppqcgdgdlkcppASAAQTTFLYFSLYLIALGYGGYQPCIATLGADQFDDEDPIEKASKSAFFS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 160 YWYMAIVLASSIAVLALIFIQERVSWSLGFSIIAGSVVIAIVIFLIGIPKYRkqvpvgspftrvaqvmvaalkkwrlsst 239
Cdd:cd17419  161 YFYQALNLGSLFSNTILVYFEDNGSWGLGFGISAGAAFIGLVLFLAGTPFYR---------------------------- 212
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 240 rhhyglcyeeedehklestnsnqvyllartnqfrfldkatiideidhnknrnpwrlctvnqveEVKLILRLIPIWISLIM 319
Cdd:cd17419  213 ---------------------------------------------------------------EVKCILRLLPIWLSTII 229
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 320 FCATLTQLNTFFLKQGSMMDRTIGNhFTIPPAAFQSIVGVTILILIPLYDRVFVPMVRKITNHHSGITSLQRIGVGLFVA 399
Cdd:cd17419  230 YSVVYTQMATLFVEQGAAMDTSFGN-FKIPPASMSVFEILSVAVGTVLYRKFLVPLLRKVTGHPKGITELQRMGIGLVIG 308
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 400 TFNMVICGLVEAKRLKVARDHGLiDSPKEVVPMSSLWLLPQYILVGIGDVFTIVGMQELFYDQMPETMRSIGAAIFISVV 479
Cdd:cd17419  309 ILAMVVAALVEIQRLKVARPSNL-DDPTSPSPLSIFWQIPQYVLVGASEVFTYVGQLEFFYDQAPDGLRSLGSALCMASV 387
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 186511048 480 GVGSFVSTGIISTVQTISKSHGEE-WLVNNLNRAHLDYYYWIIASLNAVSLCFYLFIA 536
Cdd:cd17419  388 ALGNYLSSLLVTIVNKVTTKDGSPgWIPDNLNKGHLDRFYWLLAALSGIDFVVFLICA 445
MFS_NPF8 cd17418
NRT1/PTR family (NPF), subfamily 8 of the Major Facilitator Superfamily of transporters; The ...
16-536 4.55e-131

NRT1/PTR family (NPF), subfamily 8 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF8 contains the Arabidopsis dipeptide transporters AtNPF8.1 (PTR1), AtNPF8.2 (PTR5), and AtNPF8.3 (PTR2), as well as tonoplast-localized transporters AtNPF8.4 (PTR4) and AtNPF8.5 (PTR6). Oryza sativa NRT1 (now called OsNPF8.9) is a low-affinity nitrate transporter. NPF8 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340976 [Multi-domain]  Cd Length: 447  Bit Score: 389.52  E-value: 4.55e-131
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048  16 WNAALFIIVVEIAERFAFYGLASNLITFLTNELGQSTATAAKNINTWIGVSCMFPILGAFLADSILGRFKTVLLTSFIYL 95
Cdd:cd17418    1 WKACPFILGNECCERLAYYGIATNLITYLTKELHQGNVSAANNVTNWSGTCYITPLIGAFIADAYWGRYWTIASFSAIYF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048  96 LGIVMLPLSVTV--------------VARRMREKVFFMALYVMAVGEGGHKPCVMTFAADQFGEANAEEKAAKTSFFNYW 161
Cdd:cd17418   81 IGMVLLTLSASVpglkpascigslcpPATSVQYAVFFLGLYLIALGTGGIKPCVSSFGADQFDDTDPKEKVRKSSFFNWF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 162 YMAIVLASSIAVLALIFIQERVSWSLGFSIIAGSVVIAIVIFLIGIPKYRkqvpvgspftrvaqvmvaalkkwrlsstrh 241
Cdd:cd17418  161 YFSINIGALISSSVLVWIQENVGWGWGFGIPTVFMGIAIVSFFFGTPLYR------------------------------ 210
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 242 hyglcyeeedehklestnsnqvyllartnqfrfldkatiideidhnknrnpwrlctvnqveEVKLILRLIPIWISLIMFC 321
Cdd:cd17418  211 -------------------------------------------------------------EVKILIRLLPIWASGIVFA 229
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 322 ATLTQLNTFFLKQGSMMDRTIGNhFTIPPAAFQSIVGVTILILIPLYDRVFVPMVRKITNHHSGITSLQRIGVGLFVATF 401
Cdd:cd17418  230 TVYSQMSTMFVQQGRTMDRMGGN-FEIPPASLSLFDTLSVLIWVPIYDRFIVPLVRKFTGHERGFTQLQRMGIGLFISVL 308
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 402 NMVICGLVEAKRLKVARDHGLIDSpKEVVPMSSLWLLPQYILVGIGDVFTIVGMQELFYDQMPETMRSIGAAIFISVVGV 481
Cdd:cd17418  309 SMVAAAIVEIVRLQLARTHNLVES-GPPVPMSIFWQIPQYFLIGAAEVFTFIGQLEFFYDQSPDAMRSLCSALSLLTTAL 387
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 186511048 482 GSFVSTGIISTVQTISKSHGEE-WLVNNLNRAHLDYYYWIIASLNAVSLCFYLFIA 536
Cdd:cd17418  388 GNYLSSLIVTLVTYVTTKGGKPgWIPDNLNNGHLDYFFWLLASLSFLNILVYLWIA 443
MFS_NPF1_2 cd17416
NRT1/PTR family (NPF), subfamily 1 and 2 of the Major Facilitator Superfamily of transporters; ...
21-536 1.94e-127

NRT1/PTR family (NPF), subfamily 1 and 2 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF1 includes Medicago truncatula LATD/NIP, now named MtNPF1.7, which is a high-affinity nitrate transporter and is involved in nodulation and root architecture. NPF2 members are well-established nitrate and glucosinolate transporters, including Arabidopsis nitrate influx and efflux transporters with varied tissue and developmental specificity. Examples are AtNPF2.7, which is expressed in the cortex of mature roots, and AtNPF2.9, which is expressed in root companion cells where it is involved in phloem loading. NPF1/2 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340974 [Multi-domain]  Cd Length: 444  Bit Score: 380.07  E-value: 1.94e-127
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048  21 FIIVVEIAERFAFYGLASNLITFLTNELGQSTATAAKNINTWIGVSCMFPILGAFLADSILGRFKTVLLTSFIYLLGIVM 100
Cdd:cd17416    3 FIIGNETGEKLASYGLLANLIVYLIEEYNMKSIAAANIINIWSGTTNFLPVVGAFLSDSYFGRFPTISVGSFASLLGMVL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 101 LPLSVTVVARRMRE----------------KVFFMALYVMAVGEGGHKPCVMTFAADQFGEANAEEKAAKTSFFNYWYMA 164
Cdd:cd17416   83 LTLTAAIPSLRPPPcetasslcqspsklqlAVLYSALALLSIGAGGIRPCSLAFGADQFDKKTESGKRGLESFFNWYYFT 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 165 IVLASSIAVLALIFIQERVSWSLGFSIIAGSVVIAIVIFLIGIPKYRkqvpvgspftrvaqvmvaalkkwrlsstrhhyg 244
Cdd:cd17416  163 FTVAQIISLTAIVYIQDNVSWKIGFGIPAALMLLSFILFLAGSRLYV--------------------------------- 209
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 245 lcyeeedehklestnsnqvyllartnqfrfldkatiideidhnknrnpwrlctvnqVEEVKLILRLIPIWISLIMFCATL 324
Cdd:cd17416  210 --------------------------------------------------------VEDLKSLIRVIPIWSTGIILSLAM 233
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 325 TQLNTFFLKQGSMMDRTIGNHFTIPPAAFQSIVGVTILILIPLYDRVFVPMVRKITNHHSGITSLQRIGVGLFVATFNMV 404
Cdd:cd17416  234 AQQMSLTVLQALVMDRHLGPSFQIPAGSITVFLLITLTIFIPLYDRVLVPLLRKITGRGRGLTLLQRVGIGIVFSILSMA 313
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 405 ICGLVEAKRLKVARDHGlidspKEVVPMSSLWLLPQYILVGIGDVFTIVGMQELFYDQMPETMRSIGAAIFISVVGVGSF 484
Cdd:cd17416  314 VAAIVERKRRKTALTQG-----NGTSPMSVLWLVPQLVLMGIAEAFHFIGQIEFFYQEFPESMRSTATSLFSLGMGVASY 388
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|...
gi 186511048 485 VSTGIISTVQTISKSHGEE-WLVNNLNRAHLDYYYWIIASLNAVSLCFYLFIA 536
Cdd:cd17416  389 LSSALISAVHRTTGRGGGGsWLPDDINKGRLDYVYWLLAGLGALNLGYFLVCS 441
MFS_NPF3 cd17415
NRT1/PTR family (NPF), subfamily 3 of the Major Facilitator Superfamily of transporters; The ...
16-536 2.87e-127

NRT1/PTR family (NPF), subfamily 3 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF3 is the smallest NPF subfamily and it includes Cucumis sativus nitrite transporter (CsNitr1), now named CsNPF3.2. It functions as a chloroplast nitrite uptake transporter to remove toxic nitrite from the cytosol. NPF3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340973 [Multi-domain]  Cd Length: 448  Bit Score: 379.87  E-value: 2.87e-127
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048  16 WNAALFIIVVEIAERFAFYGLASNLITFLTNELGQSTATAAKNINTWIGVSCMFPILGAFLADSILGRFKTVLLTSFIYL 95
Cdd:cd17415    1 WKTMPFIFGNEICERLASVGFHTNLITYLTLQLHMPLVKAANILTNFNGTASLTPLLGAFIADSFAGRFWTITIGSIIYQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048  96 LGIVMLPLS----------------VTVVARRMREKVFFMALYVMAVGEGGHKPCVMTFAADQFGEANAEEKAAKTSFFN 159
Cdd:cd17415   81 LGMVLLTISailpslrpppcnghevCACQASSAQLSILYLSLLLTALGSGGIRPCVVAFGADQFDESDPKQAKQTWNFFN 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 160 YWYMAIVLASSIAVLALIFIQERVSWSLGFSIIAGSVVIAIVIFLIGIPKYRkqvpvgspftrvaqvmvaalkkwrlsst 239
Cdd:cd17415  161 WYYFCMGIAILLAVTVIVYIQDNVGWGWGFGIPTIAMAISVIAFVVGSPLYR---------------------------- 212
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 240 rhhyglcyeeedehklestnsnqvyllartnqfrfldkatiideidhnknrnpwrlctvnqveEVKLILRLIPIWISLIM 319
Cdd:cd17415  213 ---------------------------------------------------------------ELKSIIRMLPIWAAGIL 229
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 320 FCATLTQLNTFFLKQGSMMDRTIGNHFTIPPAAFQSIVGVTILILIPLYDRVFVPMVRKITNHHSGITSLQRIGVGLFVA 399
Cdd:cd17415  230 LVTASSQQHTFSIQQARTMNRHLTPSFQIPPASMSVFGILSLLTTVPLYDRVLMPVARKFTGNERGITFLQRMGIGLFIS 309
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 400 TFNMVICGLVEAKRLKVARDHGLIDSPKEVVPMSSLWLLPQYILVGIGDVFTIVGMQELFYDQMPETMRSIGAAIFISVV 479
Cdd:cd17415  310 ILATVVAAFVEVKRKSVAANHGLLDRPHATVPISVFWLVPQYILHGIAEAFMSIGHLEFFYDQSPESMRSTATALFWSTI 389
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 186511048 480 GVGSFVSTGIISTVQTISKSHGEEWLVNNLNRAHLDYYYWIIASLNAVSLCFYLFIA 536
Cdd:cd17415  390 SLGSYLSTLLVTLVHKETSRGGRWWLPNNLNRGRLDYFYWLVAVLQAVNLVYFLICA 446
MFS_NPF6 cd17413
NRT1/PTR family (NPF), subfamily 6 of the Major Facilitator Superfamily of transporters; The ...
16-536 6.45e-122

NRT1/PTR family (NPF), subfamily 6 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter 1/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF6 includes the first identified member of the NRT1/PTR family: Arabidopsis thaliana NRT1.1, now called AtNPF6.3. It is a dual affinity nitrate influx transporter and a nitrate sensor. It also transports auxin and has nitrate efflux activity. NPF6 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340971 [Multi-domain]  Cd Length: 457  Bit Score: 366.78  E-value: 6.45e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048  16 WNAALFIIVVEIAERFAFYGLASNLITFLTNELGQSTATAAKNINTWIGVSCMFPILGAFLADSILGRFKTVLLTSFIYL 95
Cdd:cd17413    1 WKSAALILGIEMCERLTTLGIGVNLVTYLTGTMHLPSATSANIVTNFLGTSFLLCLLGGFIADTFLGRYLTIAIFASIQA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048  96 LGIVMLPLSVTVVARR-----------------MREKVFFMALYVMAVGEGGHKPCVMTFAADQFGEANAEEKAAKTSFF 158
Cdd:cd17413   81 LGVLVLTLSTTLPSLRpppcnhttshhcepasgIQLTVLYLALYLIALGTGGIKSSVSGFGSDQFDENDPKERKLMSYFF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 159 NYWYMAIVLASSIAVLALIFIQERVSWSLGFSIIAGSVVIAIVIFLIGIPKYRKQVPVGSpftrvaqvmvaalkkwrlss 238
Cdd:cd17413  161 NRFFFCISVGSLLAVTVLVYIQDNVGRGWGYGICAAAMVLAIVVFLAGTKRYRFKKSIGS-------------------- 220
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 239 trhhyglcyeeedehklestnsnqvyllartnqfrfldkatiideidhnknrnpwrlctvNQVEEVKLILRLIPIWISLI 318
Cdd:cd17413  221 ------------------------------------------------------------TQVEEVKMVVRMLPIWATTI 240
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 319 MFCATLTQLNTFFLKQGSMMDRTIGNhFTIPPAAFQSIVGVTILILIPLYDRVFVPMVRKITNHHSGITSLQRIGVGLFV 398
Cdd:cd17413  241 LFWTVYAQMTTFSVEQAETMDRNIGS-FEIPPASMAVFLVATILLTTAVYDRVIVPLCRKLTGHPQGLTTLQRIGVGLVF 319
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 399 ATFNMVICGLVEAKRLKVARDHGlidSPKEVVPMSSLWLLPQYILVGIGDVFTIVGMQELFYDQMPETMRSIGAAIFISV 478
Cdd:cd17413  320 SCLAMAVAALVELKRLRIAHAHG---KPVKTVPMSVFWLVPQYFLVGAGEAFIYTGQLDFFIRESPKGMKSMSTGLFLST 396
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 186511048 479 VGVGSFVSTGIISTVQTI-SKSHGEEWLVNNLNRAHLDYYYWIIASLNAVSLCFYLFIA 536
Cdd:cd17413  397 LSLGFFVSSFLVSIVNRVtGKSHPHGWLADNLNKGRLDYFYWLLAVLSALNFVIFLVFA 455
MFS_NPF4 cd17414
NRT1/PTR family (NPF), subfamily 4 of the Major Facilitator Superfamily of transporters; The ...
18-536 5.07e-121

NRT1/PTR family (NPF), subfamily 4 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. Members of the NPF4 subfamily have been shown to transport ABA. NPF4 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340972 [Multi-domain]  Cd Length: 456  Bit Score: 364.42  E-value: 5.07e-121
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048  18 AALFIIVVEIAERFAFYGLASNLITFLTNELGQSTATAAKNINTWIGVSCMFPILGAFLADSILGRFKTVLLTSFIYLLG 97
Cdd:cd17414    3 AAFFVLVVEALENMAYLANANNLVTYLINNMHYSLAKSANIVTNFVGTAFLLALLGGFLSDSFLSSFKTIIIFGSIELLG 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048  98 IVMLPLSV-----------------TVVARRMREKVFFMALYVMAVGEGGHKPCVMTFAADQFGEANAEEKAAKTSFFNY 160
Cdd:cd17414   83 LILLTVQAhipslqppscnslgdltCKEPSGSQAAILFVGLYLVALGVGCIKPNLPSHGADQFDENDPKGRRQLSSFFNW 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 161 WYMAIVLASSIAVLALIFIQERVSWSLGFSIIAGSVVIAIVIFLIGIPKYRKQvpvgspftrvaqvmvaalkkwrlsstr 240
Cdd:cd17414  163 YYFSFSLGALIAVTLVVWVEENKGWDWGFGVSAAVIAVGILVFVAGTPFYRNK--------------------------- 215
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 241 hhyglcyeeedehklestnsnqvyllartnqfrfldkatiideidhnknrnpwrlctvNQVEEVKLILRLIPIWISLIMF 320
Cdd:cd17414  216 ----------------------------------------------------------TQVEEVKIVLKMLPIFACTIIL 237
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 321 CATLTQLNTFFLKQGSMMDRTIGNHFTIPPAAFQSIVGVTILILIPLYDRVFVPMVRKITNHHSGITSLQRIGVGLFVAT 400
Cdd:cd17414  238 NCILAQLQTFSVQQGSTMNRTKIGSFNIPPASLQAIPVIFMLILVPLYDHLLVPFARKITGHESGITHLQRIGIGLVLST 317
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 401 FNMVICGLVEAKRLKVARDHGLIDSpKEVVPMSSLWLLPQYILVGIGDVFTIVGMQELFYDQMPETMRSIGAAIFISVVG 480
Cdd:cd17414  318 LSMVVAALVETKRKKVAVENGLLNS-KENLPISIFWIALQFLILGISDMFTAVGLLEFFYTESPSSMRSLGTALTWCSYS 396
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 186511048 481 VGSFVSTGIISTVQTISKS--HGEEWLVNNLNRAHLDYYYWIIASLNAVSLCFYLFIA 536
Cdd:cd17414  397 FGFYLSSVLVSVVNKVTGSggHGGWLLGENLNRDRLDLFYWLLCVLSTINFLNYLFWA 454
PTR2 pfam00854
POT family; The POT (proton-dependent oligopeptide transport) family all appear to be proton ...
84-502 3.38e-88

POT family; The POT (proton-dependent oligopeptide transport) family all appear to be proton dependent transporters.


Pssm-ID: 425909 [Multi-domain]  Cd Length: 392  Bit Score: 277.28  E-value: 3.38e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048   84 FKTVLLTSFIYLLGIVMLPLSVT-VVARRMREKVFFMALYVMAVGEGGHKPCVMTFAADQFGEANAEEKaakTSFFNYWY 162
Cdd:pfam00854   1 FRTIFLGSIIYAIGHILLALSAIpSLRPPVHVALFFIGLALIALGTGGIKPNVSSFGGDQFEETDPRRR---SRFFSIFY 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048  163 MAIVLASSIAVLALIFIQERVSWSLGFSIIAGSVVIAIVIFLIGIPKYRKQVPVGSPFTRVAQVMVAALKKwRLSSTRHH 242
Cdd:pfam00854  78 FSINAGSLISTIITPYLQQNYGYPLGFGLPAVGMIIALLVFLLGSRMYKKKPPKGNVLTKVFKVLPVAAWN-KVKLNGSS 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048  243 YGLCYEEEDEHklestnsnqvyllartnqFRFLDKATIIDEIDHNKNRNPWrlCTVNQVEEVKLILRLIPIWISLIMFCA 322
Cdd:pfam00854 157 AGIKKLHWLDW------------------ARELDALIILGIVVPGIFFNIW--CTKTKVEEVKRLLRVLPLFLPLIMFWA 216
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048  323 TLTQLNTFFLKQGSMMDRTIGnHFTIPPAAFQSIVGVTILILIPLYDRVFVPMVRKITNhhsGITSLQRIGVGLFVATFN 402
Cdd:pfam00854 217 LYDQMGTSWVLQARTMNRKIG-SFEIPPAQFQAFNAILVLIFIPIFDRLVYPLGRKCTG---GLTPLQKMAVGLFLASLA 292
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048  403 MVICGLVEAKRLKVARDHGlidsPKEVVPMSSLWLLPQYILVGIGDVFTIVGMQELFYDQMPETMRSIGAAIFISVVGVG 482
Cdd:pfam00854 293 FAIAAIVQLKRNDTGPEFP----IAQEVPISVLWLIPQYLLIGFGELFISIGGLEFFYKLAPKSMTSLITGLFLLTNALG 368
                         410       420
                  ....*....|....*....|
gi 186511048  483 SFVSTGIISTVQTISKSHGE 502
Cdd:pfam00854 369 NFLSGVIATLTAKPTNVLGA 388
MFS_POT cd06175
Proton-coupled oligopeptide transporter (POT) family of the Major Facilitator Superfamily of ...
22-536 8.06e-68

Proton-coupled oligopeptide transporter (POT) family of the Major Facilitator Superfamily of transporters; The Proton-coupled oligopeptide transporter (POT) family is present across all major kingdoms of life and is known by a variety of names. It is referred to as the Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) in plants, and in addition to POT, it is also known as the Peptide transporter (PepT/PTR) or Solute Carrier 15 (SLC15) family in animals. Members of this family are proton-driven symporters involved in nitrogen acquisition in the form of di- and tripeptides. Plant members transport other nitrogenous ligands including nitrate, the plant hormone auxin, and glucosinolate compounds that are important for seed defense. POT proteins exhibit substrate multispecificity, with one transporter able to recognize as many as 8,400 types of di/tripeptides and certain peptide-like drugs. The POT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340865 [Multi-domain]  Cd Length: 422  Bit Score: 225.39  E-value: 8.06e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048  22 IIVVEIAERFAFYGLASNLITFLTNELGQSTATAAKNINTWIGVSCMFPILGAFLADSILGRFKTVLLTSFIYLLGIVML 101
Cdd:cd06175    4 ILLIELCERFTFYGIGANLVPFLTGALGLGNAQAANVVLNFLGTSYVTPLFGGWIADTFLGRYRTILIGAAIYAVGVAIL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 102 PL--------------SVTVVARRMREKVFFMALYVMAVGEGGHKPCVMTFAADQFGEanaEEKAAKTSFFNYWYMAIVL 167
Cdd:cd06175   84 TVstippglrplrcnpSHCEQASGIQLTGFYAALYLIALGTGGVKANVSPLGADQFDE---RGPSKTQSFFNWFYFCINV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 168 ASSIAVLALIFIQERVSWSLGFSIIAGSVVIAIVIFligipkyrkqvpvgspftrvaqvmvaalkkwrlsstrhhyglcy 247
Cdd:cd06175  161 GSLLAMLGTPYIQDNVGWAAAYGIPFVAILLALVVF-------------------------------------------- 196
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 248 eeedehklestnsnqvyllartnqfrfldkatiideidhnknrnpwrlctvnqveEVKLILRLIPIWISLIMFCATLTQL 327
Cdd:cd06175  197 -------------------------------------------------------EVKQLLRALPLFAFCILFWTVYAQM 221
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 328 NTFFLKQGSMMDRTIGNHfTIPPAAFQSIVGVTILILIPLYDRVFVPMVRkitNHHSGITSLQRIGVGLFVATFNMVICG 407
Cdd:cd06175  222 TTSYVLQALTLVRSTGLF-TIPPASMQAFNPILLLLLIPVLDKVVYPLIR---RYGVGLSPLTKIGLGFFFGSLSMFVAG 297
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 408 LVEAKRLKVARDHGLIDSPKevvPMSSLWLLPQYILVGIGDVFTIVGMQELFYDQMPETMRSIGAAIFISVVGVGSFVST 487
Cdd:cd06175  298 FLELKRLNTAHAHGPVVTTS---PLSFWWQIPQYLLLGIGEILVSITGLEFAYREAPKSMKGFIMGLLLLTSGFGSFFGS 374
                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*....
gi 186511048 488 GIISTVQTISkshGEEWLVNNLNRAHLDYYYWIIASLNAVSLCFYLFIA 536
Cdd:cd06175  375 VLVTLVSKPT---DGAHIADDLNKGVLTNFFFLLAVLAALNFLIFLLVS 420
MFS_SLC15A1_2_like cd17347
Solute carrier family 15 members 1 and 2, and similar Major Facilitator Superfamily ...
21-536 3.20e-55

Solute carrier family 15 members 1 and 2, and similar Major Facilitator Superfamily transporters; Solute carrier family 15 member 1 (SLC15A1) and SLC15A2 are members of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. They mediate the proton-coupled active transport of a broad range of dipeptides and tripeptides, including zwitterionic, anionic and cationic peptides, as well as a variety of peptide-like drugs such as cefadroxil, enalapril, and valacyclovir. SLC15A1, or peptide transporter 1 (PepT1), is primarily expressed in the brush border membranes of enterocytes of the small intestine and is also known as the intestinal isoform. SLC15A2, or peptide transporter 2 (PepT2), is abundantly expressed in the apical membrane of kidney proximal tubules and is also referred to as the renal isoform. Both proteins transport di/tripeptides, but not tetrapeptides or free amino acids, using the energy generated by an inwardly directed transmembrane proton gradient. The SLC15A1/SLC15A2-like group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340905 [Multi-domain]  Cd Length: 427  Bit Score: 192.06  E-value: 3.20e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048  21 FIIVVEIAERFAFYGLASNLITFLTNELGQSTATAAKNINTWIGVSCMFPILGAFLADSILGRFKTVLLTSFIYLLGIVM 100
Cdd:cd17347    6 FIVGNEFCERFSYYGMRAILVLYLTDFLGFSEAEATAIYHSFVMLCYFFPLLGAIIADSYLGKYRTILYLSLVYCLGHIV 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 101 LPLSVTVVARRMREKVFFMALYVMAVGEGGHKPCVMTFAADQFGEANAEEKAaktSFFNYWYMAIVLASSIA------VL 174
Cdd:cd17347   86 LAVTAIPPLGPPHVWGLLIGLLLIAIGTGGIKPCVSAFGGDQFGADQQHLLA---RFFSWFYFAINAGSLLStfltpiLR 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 175 ALIFIQERVSWSLGFSIIAGSVVIAIVIFLIGipkyrkqvpvgspftrvaqvmvaalkkwrlsstRHHYglcyeeedehk 254
Cdd:cd17347  163 ADVQFGGHDCYPLAFGVPGVLMAVATLVFWLG---------------------------------RKHY----------- 198
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 255 lestnsnqvyllartnqfrfldkatiideidhnknrnpwrlctvnqvEEVKLILRLIPIWISLIMFCATLTQLNTFFLKQ 334
Cdd:cd17347  199 -----------------------------------------------KDVKALLRVLVLFIPLPVFWALFDQQGSRWTLQ 231
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 335 GSMMDRTIGnHFTIPPAAFQSIVGVTILILIPLYDRVFVPMVRKItnhhsGI--TSLQRIGVGLFVATFNMVICGLVEAK 412
Cdd:cd17347  232 AEQMDGLVG-GFTILPDQMQALNPILILILIPLFDYVIYPLLERC-----GIplTPLRKMGVGMILAALAFVIAGFLQLR 305
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 413 ---RLKVARDHGLIDSPKEVVP--MSSLWLLPQYILVGIGDV-FTIVGMqELFYDQMPETMRSIGAAIFISVVGVGSFVS 486
Cdd:cd17347  306 idgGLPGQPDPGEVTTFEDIEPnsVSILWQLPQYVVLTAGEVlFSITGL-EFAYTQAPKSMKSVVQAAWLLTVALGNLIV 384
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|
gi 186511048 487 TGIISTVQTISKSHgeewlvnnlnrahldyYYWIIASLNAVSLCFYLFIA 536
Cdd:cd17347  385 VIVAELIQFSSQAA----------------EYFFFAGLMLVVAVVFALLA 418
MFS_SLC15A3_4 cd17348
Solute Carrier family 15 members 3 and 4 of the Major Facilitator Superfamily of transporters; ...
22-536 5.37e-49

Solute Carrier family 15 members 3 and 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 15 members 3 (SLC15A3) and 4 (SLC15A4) are members of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. They are peptide/histidine transporters (PHTs) that transport free histidine in addition to di/tripeptides. SLC15A4, also called peptide transporter 4 or peptide/histidine transporter 1 (PHT1), is expressed in the human brain, retina, placenta, and immune cells. It is required for Toll-like receptor 7 (TLR7)- and TLR9-mediated type I interferon production in plasmacytoid dendritic cells (pDCs) and is involved in the pathogenesis of lupus-like autoimmunity. SLC15A3, also called osteoclast transporter, peptide transporter 3, or peptide/histidine transporter 2 (PHT2), is expressed in immune tissues including the spleen and thymus. The SLC15A3/SLC15A4 group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340906 [Multi-domain]  Cd Length: 435  Bit Score: 175.36  E-value: 5.37e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048  22 IIVVEIAERFAFYGLASNLITFLTNE-LGQSTATAAKNINTWIGVSCMFPILGAFLADSILGRFKTVLLTSFIYLLGIVM 100
Cdd:cd17348    7 VLLVELLERAAFYGITSNLVLFLNGSpFNWEGTQASQALLLFMGATYLLSPFGGWLADAYLGRFWTILLSLLLYLLGMLL 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 101 LPLSVTvvarrmreKVFFMALYVMAVGEGGHKPCVMTFAADQFGEANAEekaAKTSFFNYWYMAIVLASSIAVLALIFIQ 180
Cdd:cd17348   87 FPATAA--------PALYAGLLLVGLGVGSVKANITPFGADQVKDRGPE---ATRRFFNWFYWSINLGAILSLGGVAYIQ 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 181 ERVSWSLGFSIIAGSVVIAIVIFLIGIPkyrkqvpvgspftrvaqvmvaalkkwrlsstrhhyglcyeeedehklestns 260
Cdd:cd17348  156 QNVSFLIGYSIPAVCVGLAFLVFLCGQP---------------------------------------------------- 183
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 261 nqvyllartnqfrfldkaTIIDeidhnknrnpwrlctvnqveeVKLILRLIPIWISLIMFCATLTQLNTFFLKQG----- 335
Cdd:cd17348  184 ------------------VFID---------------------VKALVKILPVFLALIPYWTVYFQMQTTYVLQSlhlki 224
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 336 -----SMMDRTIGNHFTIPPAAFQSIVGVTILILIPLYDRVFVPMVRKitnHHSGITSLQRIGVGLFVATFNMVICGLVE 410
Cdd:cd17348  225 pnifiSNIAGITNSSHTFPAAWLTMFDAVLILILIPLKDKLVDPFLKR---RGLLPSSLKRIAVGMFFVMCSAIAAGILE 301
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 411 AKRLKVARDHGLIDSP-KEVV----PMSSLWLLPQYILVGIGDVFTIVGMQELFYDQMPETMRSIGAAIFISVVGVGSFV 485
Cdd:cd17348  302 SKRLEIVKHNTTIQQQiGNVTyyaaDLPIWWQIPQYLLIGISEIFASIAGLEFAYSAAPKSMQSAIMGLFFFFSGVGSFV 381
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 186511048 486 STGIISTVQTisKSHGeeWLVN-----NLNRAHLDYYYWIIASLNAVSLCFYLFIA 536
Cdd:cd17348  382 GSGLLALVSI--KEIG--WMSShkdfgNINGCRLNYYFFLLAGIQGVTLLLFLIIS 433
2A1704 TIGR00926
Peptide:H+ symporter (also transports b-lactam antibiotics, the antitumor agent, bestatin, and ...
31-415 2.63e-35

Peptide:H+ symporter (also transports b-lactam antibiotics, the antitumor agent, bestatin, and various protease inhibitors); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273343 [Multi-domain]  Cd Length: 654  Bit Score: 140.67  E-value: 2.63e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048   31 FAFYGLASNLITFLTNELGQSTATAAKNINTWIGVSCMFPILGAFLADSILGRFKTVLLTSFIYLLGIVMLPL-SVTVVA 109
Cdd:TIGR00926   1 FSYYGMRTILVLYFLNFLGFSESTSTVLFHTFTYLCYLTPLIGAIIADGWLGKFKTILYLSIVYVVGHALLSFgAIPSSG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048  110 RRMREKVFFMALYVMAVGEGGHKPCVMTFAADQFGEANAEekaAKTSFFNYWYMAIVLASSIAVLALIFIQERVS----- 184
Cdd:TIGR00926  81 HPLHDLLDLLGLALIALGTGGIKPCVSAFGGDQFEERQLS---LRSRFFSFFYFAINAGSLISTIITPILRGDVGcfgcq 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048  185 --WSLGFSIIAGSVVIAIVIFLIGIPKYRKQVPVGSPFTRVAQVMVAALKKWrlSSTRHhyglcyEEEDEHKLESTnsnq 262
Cdd:TIGR00926 158 dcYPLAFGVPAILMILALIVFMAGSKMYKKKPPKGNIVSKVIKCIVTALRKR--FSTRS------EHWPLHWLDYA---- 225
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048  263 vyllartnqfrfLDKATIIDeidhnknrnpwrlctvnqVEEVKLILRLIPIWISLIMFCATLTQLNTFFLKQGSMMDRTI 342
Cdd:TIGR00926 226 ------------KDKHDIRM------------------IRSTKRLLRVLVLFIPLPMFWALFDQQGSRWTLQATRMDGDV 275
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 186511048  343 GnHFTIPPAAFQSIVGVTILILIPLYDRVFVPMVRKITNHhsgITSLQRIGVGLFVATFNMVICGLVEAKRLK 415
Cdd:TIGR00926 276 G-GFEIQPDQMQVVNPLLILIFVPIFDYIVYPAIAKCGTR---FTSLRKMAVGGLLAALSFFVAALVQLKVNP 344
PTR2 COG3104
Dipeptide/tripeptide permease [Amino acid transport and metabolism];
21-492 6.61e-33

Dipeptide/tripeptide permease [Amino acid transport and metabolism];


Pssm-ID: 442338 [Multi-domain]  Cd Length: 479  Bit Score: 131.48  E-value: 6.61e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048  21 FIIVVEIAERFAFYGLASNLITFLTNEL-----GQSTATAAKNINTWIGVSCMFPILGAFLADSILGRFKTVLLTSFIYL 95
Cdd:COG3104   18 TLFFTEMWERFSFYGMRAILVLYLTASLadgglGLSEADAAAIYGAYTALVYLTPLLGGWLADRLLGQRRAILLGGILMA 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048  96 LGIVMLPLSVTVVArrmrekvFFMALYVMAVGEGGHKPCVMTFAADQFGEANAEEKAAktsfFNYWYMAIVLASSIAVLA 175
Cdd:COG3104   98 LGHFLLALPGGVTL-------FYLGLALIAVGNGLFKPNISSLVGQLYDPGDPRRDAG----FTIFYMGINIGAFLAPLL 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 176 LIFIQERVSWSLGFSIIAGSVVIAIVIFLIGIPKYR----KQVPVGSPFTRVAQVMVAALKKWRLSSTRHHYglcyeeed 251
Cdd:COG3104  167 CGYLGEKYGWHYGFGAAAIGMLIGLIIFLLGRKYLGdiglEPDNPLSKKERLIAVALGALLLVLVLAGLLSN-------- 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 252 ehklESTNSNQVYLLARTNQFRFLDKATIIDeidhnknrnpwrlctvnqVEEVKLILRLIPIWISLIMFCATLTQ----L 327
Cdd:COG3104  239 ----ANIANYLLYVIAIIAYFIFILRSKKLT------------------KEERKRLLAILILFLFSIVFWALYEQagtsL 296
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 328 NTFFLKqgsMMDRTIGNhFTIPPAAFQSIVGVTILILIPLYDRVFVPMVRKITNhhsgITSLQRIGVGLFVATFNMVICG 407
Cdd:COG3104  297 NLFADR---NVDRSLFG-FEIPPSWFQSLNPLFIIILAPVFAALWTKLGKRGKE----PSTPTKFALGLLLLGLGFLVMA 368
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 408 LVEakrlKVARDHGLIdspkevvpmSSLWLLPQYILVGIGDVFT-IVGMqELFYDQMPETMRSIGAAIFISVVGVGSFVS 486
Cdd:COG3104  369 LAA----LLAGAGGKV---------SPLWLVLAYLLLTIGELCLsPVGL-SMITKLAPARFAGQMMGLWFLATALGNLLA 434

                 ....*.
gi 186511048 487 tGIIST 492
Cdd:COG3104  435 -GLLAG 439
MFS_SLC15A1 cd17412
Solute Carrier family 15 member 1 of the Major Facilitator Superfamily of transporters; Solute ...
21-502 3.80e-31

Solute Carrier family 15 member 1 of the Major Facilitator Superfamily of transporters; Solute carrier family 15 member 1 (SLC15A1), also called peptide transporter 1 (PepT1), is a member of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. SLC15A1, as well as SLC15A2, mediate the proton-coupled active transport of a broad range of dipeptides and tripeptides, including zwitterionic, anionic and cationic peptides, as well as a variety of peptide-like drugs such as cefadroxil, enalapril, and valacyclovir. SLC15A1 is primarily expressed in the brush border membranes of enterocytes of the small intestine and is also known as the intestinal isoform. It is a high-capacity/low-affinity transporter that drives the transport of di-and tripeptides for metabolic purposes. It's expression is upregulated in the colon during chronic inflammation associated with inflammatory bowel disease. SLC15A1/PepT1 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340970 [Multi-domain]  Cd Length: 415  Bit Score: 125.34  E-value: 3.80e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048  21 FIIVVEIAERFAFYGLASNLITFLTNELGQSTATAAKNINTWIGVSCMFPILGAFLADSILGRFKTVLLTSFIYLLGIVM 100
Cdd:cd17412    6 FIVVNEFCERFSYYGMRAVLVLYFKYFLRWDDDLSTAIYHTFVALCYLTPILGAIIADSWLGKFKTIVYLSIVYTIGQAV 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 101 LPLSV-----------TVVARRMREKVFFMALYVMAVGEGGHKPCVMTFAADQFGEANAEEkaaKTSFFNYWYMAIVLAS 169
Cdd:cd17412   86 MAVSAihdltdanrdgTPDNLTLHVALSMIGLLLIALGTGGIKPCVAAFGGDQFEEHQEKQ---RSRFFSIFYLSINAGS 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 170 SIAVL--ALIFIQE------RVSWSLGFSIIAGSVVIAIVIFLIGIPKYRkqvpvgspftrvaqvmvaalkkwrlsstrh 241
Cdd:cd17412  163 LLSTIitPILRSQEcgihskQKCYPLAFGVPAALMVVALIVFILGSKMYK------------------------------ 212
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 242 hyglcyeeedehklestnsnqvyllartnqfrfldkatiideidhnknrnpwrlctvnqveEVKLILRLIPIWISLIMFC 321
Cdd:cd17412  213 -------------------------------------------------------------QIKMVLKVLFLYIPLPMFW 231
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 322 ATLTQLNTFFLKQGSMMDRTIGNhFTIPPAAFQSIVGVTILILIPLYDRVFVPMVRKITNHhsgITSLQRIGVGLFVATF 401
Cdd:cd17412  232 ALFDQQGSRWTLQATTMDGNFGA-IQIQPDQMQTVNPILIIIMVPIFDAVIYPLIKKCKIN---FTPLRKMTVGMFLAAL 307
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 402 NMVICGLVEakrlkvardhglidspkevVPMSslWLLPQYILVGIGDV-FTIVGMqELFYDQMPETMRSIGAAIFISVVG 480
Cdd:cd17412  308 AFVAAALLQ-------------------IQMA--WQIPQYFLLTCGEVvFSVTGL-EFSYSQAPSNMKSVLQAGWLLTVA 365
                        490       500
                 ....*....|....*....|..
gi 186511048 481 VGSFVSTgIISTVQTISKSHGE 502
Cdd:cd17412  366 VGNIIVL-IVAEAGSISEQWAE 386
MFS_SLC15A2 cd17411
Solute carrier family 15 member 2 of the Major Facilitator Superfamily of transporters; Solute ...
21-485 5.57e-30

Solute carrier family 15 member 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 15 member 2 (SLC15A2), also called peptide transporter 2 (PepT2), is a member of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. SLC15A2, as well as SLC15A1, mediate the proton-coupled active transport of a broad range of dipeptides and tripeptides, including zwitterionic, anionic and cationic peptides, as well as a variety of peptide-like drugs such as cefadroxil, enalapril, and valacyclovir. SLC15A2 is a high-affinity transporter and is abundantly expressed in the apical membrane of kidney proximal tubules and choroid plexus epithelial cells. It is the major transporter involved in the reclamation of peptide-bound amino acids and peptide-like drugs in the kidney, and is also called the renal isoform. In choroid plexus and the brain, it acts as an efflux transporter and plays a role in regulating peptide/neuropeptide homeostasis. SLC15A2/PepT2 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340969 [Multi-domain]  Cd Length: 403  Bit Score: 121.86  E-value: 5.57e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048  21 FIIVVEIAERFAFYGLASNLITFLTNELGQSTATAAKNINTWIGVSCMFPILGAFLADSILGRFKTVLLTSFIYLLGIVM 100
Cdd:cd17411    6 FIVVNEFCERFSYYGMKAVLTLYFLSFLHWDENLSTAIYHAFSGLCYFTPVLGALIADSWLGKFKTIIYLSIVYVVGHVI 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 101 LPLSV--TVVARRMREKVFFMALYVMAVGEGGHKPCVMTFAADQFGEANAEEkaaKTSFFNYWYMAIVLASSIAVLALIF 178
Cdd:cd17411   86 KSVGAipTVGDQQVHVVLSMIGLFLIALGTGGIKPCVAAFGGDQFEEEHARE---RSKFFSIFYLSINAGSLISTFVTPI 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 179 IQERVS------WSLGFSIIAGSVVIAIVIFLIGIPKYRkqvpvgspftrvaqvmvaalkkwrlsstrhhyglcyeeede 252
Cdd:cd17411  163 LRGDVQcfggdcYALAFGVPAALMVVALVVFIAGSGMYK----------------------------------------- 201
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 253 hklestnsnqvyllartnqfrfldkatiideidhnknrnpwrlctvnqveEVKLILRLIPIWISLIMFCATLTQLNTFFL 332
Cdd:cd17411  202 --------------------------------------------------EVKMVTRVLFLYIPLPMFWALFDQQGSRWT 231
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 333 KQGSMMDRTIGNhFTIPPAAFQSIVGVTILILIPLYDRVFVPMVRKItnhHSGITSLQRIGVGLFVAtfnmvicglveak 412
Cdd:cd17411  232 LQATRMNDFGGG-FVLQPDQMQTLNPLLILVFIPIFDLGIYPLVSKC---KINFTSLRKMATGMILA------------- 294
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 186511048 413 rlkvardhGLIDSPKEVVPMSSLWLLPQYILVGIGDV-FTIVGMqELFYDQMPETMRSIGAAIFISVVGVGSFV 485
Cdd:cd17411  295 --------ALAFAVAAAVEIKIAWQLPQYVLLSAGEVmFSITGL-EFSYSQAPASMKSVLQAGWLLTVAFGNVI 359
MFS_SLC15A5 cd17349
Solute Carrier family 15 member 5 of the Major Facilitator Superfamily of transporters; Solute ...
22-532 1.88e-25

Solute Carrier family 15 member 5 of the Major Facilitator Superfamily of transporters; Solute carrier family 15 member 5 (SLC15A5) is a member of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. The specific function of SLC15A5 is unknown. SLC15A5 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340907 [Multi-domain]  Cd Length: 437  Bit Score: 109.07  E-value: 1.88e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048  22 IIVVEIAERFAFYGLASNLITFLTNELGQSTATAAKNINTWIGVSCMFPILGAFLADSILGRFKTVLLTSFIYLLGIVML 101
Cdd:cd17349    7 LLLVELCERFTFFGIVCNMILFCTIKLGYRNHQAAIVNLCFVGTSTLTPVFVGWLAEECMGRNKLVYICLFLHFLGTALL 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 102 PL--------------SVTVVARRMREKVFFMALYVMAVGEGGHKPCVMTFAADQFGEANAEEKaakTSFFNYWYMAIVL 167
Cdd:cd17349   87 PVvafpfedfyidthhIIHTLAKREQTLLFYVALLTASLGTGGIRAIVCPLSAYGLQDYGSRKL---MSFFNWFYWLVNL 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 168 ASSIAVLALIFIQERVSWSLGFSIIAGSVVIAIVifligipkyrkqvpvgspftrvaqvmvaalkkwrlsstrhhyglcy 247
Cdd:cd17349  164 NSAVVFVGISYIQQSVAKNLGFLIPFMSVLMALI---------------------------------------------- 197
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 248 eeedehklestnsnQVYLLArtnqfrfldkatiideidhnknrnpwrlctvNQVEEVKLILRLIPIWISLIMFCATLTQL 327
Cdd:cd17349  198 --------------TLHMVR-------------------------------NDLINTKNLVRLFPLFAFQILYRTCIMQI 232
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 328 NTFFLKQGSMMDRTIGNhFTIPPAAFQSIVGVTILILIPLYDRV---FVPMVRkitnhhSGITSLQRIGVGLFVATFNMV 404
Cdd:cd17349  233 PSGYYLQTMNSNLNLGG-FLLPIAAMNVISIIPLLILAPFLEYFsscLFSSKR------YGPFLSACIIAGHLCAALSVM 305
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 405 ICGLVEAKR-LKVARDHGLIDSPKEVVPMSSLWLLPQYILVGIGDVFTIVGMQELFYDQMPETMRSIGAAIFISVVGVGS 483
Cdd:cd17349  306 VAGFSEIHRkRFPLVEQTLSGKVLLVSSMPCFQLAPQYVLLGVAEALVTPACSLITFRLVPSSIRGISMHFLTLFNGAGC 385
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|
gi 186511048 484 FVSTGIISTVQTISkshGEEWLVNNLNRAHLDYYYWIIASLNAVS-LCFY 532
Cdd:cd17349  386 FMGALLIQLVYLIS---EGNWFPNTLNKGNLERFFFFLASLMLLNaLGFW 432
MFS_PTR2 cd17350
Peptide transporter PTR2 of the Major Facilitator Superfamily of transporters; Fungal peptide ...
19-492 6.41e-22

Peptide transporter PTR2 of the Major Facilitator Superfamily of transporters; Fungal peptide transporter or permease PTR2 is a member of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. It is a 12-transmembrane domain (TMD) integral membrane protein that translocates di-/tripeptides. As with other POT family proteins, it displays characteristic substrate multispecificity. PTR2 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340908 [Multi-domain]  Cd Length: 438  Bit Score: 98.31  E-value: 6.41e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048  19 ALFIIVVEIAERFAFYGLA---SNLITFLTNE-------LGQSTATAAKNINT-WIGVscmFPILGAFLADSILGRFKTV 87
Cdd:cd17350    4 AFLIAIVELCERFSYYGLTgpfQNYMQFGPDDstpgalgLGEQGATGLSNFFTfWCYV---TPVIGAYVADQFLGRYNTI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048  88 LLTSFIYLLGIVMLPLSV--TVVARRMREKVFFMALYVMAVGEGGHKPCVMTFAADQFGEANAEEKAAKTS--------- 156
Cdd:cd17350   81 VCGAVIYFVGILILTCTSipSVIDAGAGLGGFVVAIIIIGLGTGGIKSNVSPLIADQLPKIKPYVKTLKNGervivdpvv 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 157 ----FFNYWYMAIVLAsSIAVLALIFIQERVSWSLGFSIIAGSVVIAIVIFLIGIPKYRKqvpvgspftrvaqvmvaalk 232
Cdd:cd17350  161 tlsrIYMIFYWAINVG-SLSLLATTYLERTKGFWYAYLLPLCVFVIPLIILAFGKKFYKI-------------------- 219
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 233 kwrlsstrhhyglcyeeedehklestnsnqvyllaRTNQFrfldkatiideidhnknrnpwrlctvnqVEEVKLILRLIP 312
Cdd:cd17350  220 -----------------------------------RPDLF----------------------------IDELKRALRACK 236
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 313 IWISLIMFCATLTQLNTFFLKQGSMMDrtIGNhftIPPAAFQSIVGVTILILIPLYDRVFVPMVRKITNHHSGITslqRI 392
Cdd:cd17350  237 VFLFYPIYWVCYGQMTSNFISQAGQMQ--LHG---VPNDLFQAFDSIALIIFIPILENIIYPLLRKYNIPFKPIT---RI 308
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 393 GVGLFVATFNMVICGLVEAKRLKVARDHGLIDSPKEVVPMSSLWLLPQYILVGIGDVFTIVGMQELFYDQMPETMRSIGA 472
Cdd:cd17350  309 TLGFMFASFSMIYAAVLQAKIYQAGPCYANPTGTCSPNDIHVWIQIPAYVLIAFSEIFASITGLEYAYTKAPPSMKSFIT 388
                        490       500
                 ....*....|....*....|
gi 186511048 473 AIFISVVGVGSFVSTGIIST 492
Cdd:cd17350  389 ALFLLTNAFGAALSIAISPA 408
MFS_DtpA_like cd17346
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ...
19-210 4.10e-21

Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340904 [Multi-domain]  Cd Length: 399  Bit Score: 95.72  E-value: 4.10e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048  19 ALFIIV-VEIAERFAFYGLASNLITFLTNELGQ--STATAAKNINTWIGVSCMFPILGAFLADSILGRFKTVLLTSFIYL 95
Cdd:cd17346    3 GLYTLFfTEMWERFSYYGMRAILILYLTAQLGDgfSEADAASIYGAYTALVYLTPIIGGWLADKVLGARRTVFIGGILMA 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048  96 LGIVMLPLSVTVVArrmrekVFFMALYVMAVGEGGHKPCVMTFAADQFGEANAEEKAAktsfFNYWYMAIVLASSIAVLA 175
Cdd:cd17346   83 LGYLLLALSPFSVS------MLYLGLALIIVGNGLFKPNISSLVGKLYDENDPRRDSG----FSIFYMGINLGAFLAPLL 152
                        170       180       190
                 ....*....|....*....|....*....|....*
gi 186511048 176 LIFIQERVSWSLGFSIIAGSVVIAIVIFLIGIPKY 210
Cdd:cd17346  153 CGTLGDNYGYHYGFGLAAVGMLLGLLIFLLGRKKL 187
PRK15462 PRK15462
dipeptide permease;
18-206 3.33e-17

dipeptide permease;


Pssm-ID: 237971 [Multi-domain]  Cd Length: 493  Bit Score: 84.61  E-value: 3.33e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048  18 AALFIIVVEIAERFAFYGLASNLITFLTNELGQSTATAAKNINTWIGVSCMFPILGAFLADSILGRFKTVLLTSFIYLLG 97
Cdd:PRK15462  10 AIYYVVALQIWEYFSFYGMRALLILYLTNQLKYDDNHAYELFSAYCSLVYVTPILGGFLADKVLGNRMAVMLGALLMAIG 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048  98 IVMLPlsvtvvARRMREKVFFMALYVMAVGEGGHKPCVMTFaadqFGEANAEEKAAKTSFFNYWYMAIVLASSIAVLALI 177
Cdd:PRK15462  90 HVVLG------ASEIHPSFLYLSLAIIVCGYGLFKSNVSCL----LGELYEPTDPRRDGGFSLMYAAGNVGSIIAPIACG 159
                        170       180
                 ....*....|....*....|....*....
gi 186511048 178 FIQERVSWSLGFSIIAGSVVIAIVIFLIG 206
Cdd:PRK15462 160 YAQEEYSWAMGFGLAAVGMIAGLVIFLCG 188
yjdL_sub1_fam TIGR00924
amino acid/peptide transporter (Peptide:H+ symporter), bacterial; The model describes ...
22-378 2.56e-13

amino acid/peptide transporter (Peptide:H+ symporter), bacterial; The model describes proton-dependent oligopeptide transporters in bacteria. This model is restricted in its range in recognizing bacterial proton-dependent oligopeptide transporters, although they are found in yeast, plants and animals. They function by proton symport in a 1:1 stoichiometry, which is variable in different species. All of them are predicted to contain 12 transmembrane domains, for which limited experimental evidence exists. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273342 [Multi-domain]  Cd Length: 475  Bit Score: 72.18  E-value: 2.56e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048   22 IIVVEIAERFAFYGLASNLITFL--TNELGQSTATAAKNINTWIGVSCMFPILGAFLADSILGRFKTVLLTSFIYLLGIV 99
Cdd:TIGR00924  15 LFFVELWERFSYYGMQGILAVYLvqQAGLGFSQEQAFIIFGAYSALVYLLTSVGWWFGDRVWGTKKTMVLGGIVLMLGHF 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048  100 MLPLSVTVvarrmreKVFFMALYVMAVGEGGHKPCVMTFAADQFGEANAEEKAAKTSFFnywYMAIVLASSIAVLALIFI 179
Cdd:TIGR00924  95 MLAMSIYP-------DLIFYGLGTIAVGSGLFKANPSSMVGKLYERGDMPRRDGGFTLF---YMSINIGSFISPLLAGVI 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048  180 QERVSWSLGFSIIAGSVVIAIVIFLIG------IPKYRKQVPV-GSPFTRVAQVMVAALK-----KWRLSstrHHYGLcy 247
Cdd:TIGR00924 165 AENYGYHVGFNLAAVGMVIGLLTFFAGrhmlrdIGSVPDPLSGqGKTYGKLLLALLAALAlvffcAWLMH---HVVIA-- 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048  248 eeedeHKLESTnsnqvYLLARTNQFRFLDKATIIDEIDHNKnrnpwrlctvnqveevklILRLIPIWISLIMFCATLTQ- 326
Cdd:TIGR00924 240 -----NILLMT-----VTLAVIIFFFRLAFKPRLDAVARNK------------------MYAYIVLFLEAVVFWVLYAQm 291
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 186511048  327 ---LNTFFLkqgSMMDRTIGNhFTIPPAAFQSIVGVTILILIPLYDRVFVPMVRK 378
Cdd:TIGR00924 292 ptsLNFFAD---NNMHHEMLG-MSVPVIWFQSLNPFWVVVGSPVLAMIWTRLGRK 342
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
31-212 7.97e-09

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 57.57  E-value: 7.97e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048  31 FAFYGLASNLITFLTNELGQSTATAAkNINTWIGVSCMF-PILGAFLADSILGRFKTVLLTSF-IYLLGIVMLPLSVTVV 108
Cdd:COG2271  194 FALYGFLTWLPTYLVEVRGLSLAQAG-LLLSLPFLAGIVgSLLGGWLSDRLGRRRKLVLAIGLlLAALALLLLALLPSPA 272
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 109 arrmrekVFFMALYVMAVGEGGHKPCVMTFAADQFGEANAeekAAKTSFFNywyMAIVLASSIAVLALIFIQERVSWSLG 188
Cdd:COG2271  273 -------LAIALLFLAGFGLGGAFGLLWALAAELFPKKAR---GTASGLVN---TFGFLGGALGPLLVGYLLDATGYQAA 339
                        170       180
                 ....*....|....*....|....
gi 186511048 189 FSIIAGSVVIAIVIFLIGIPKYRK 212
Cdd:COG2271  340 FLLLAALALLAALLALLLLRETRK 363
tppB PRK09584
dipeptide/tripeptide permease DtpA;
17-204 9.43e-09

dipeptide/tripeptide permease DtpA;


Pssm-ID: 181969  Cd Length: 500  Bit Score: 57.85  E-value: 9.43e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048  17 NAALFIIVVEIAERFAFYGLASNLITFLTNELGQSTATAAKNINTWIGVSCMFPILGAFLADSILGRFKTVLLTSFIYLL 96
Cdd:PRK09584  21 KAFYLIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWLGDKVLGTKRVIMLGAIVLAI 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048  97 GIVMLPLSVTVVArrmrekVFFMALYVMAVGEGGHKPCVMTFAADQFGEANAEEKAAktsfFNYWYMAIVLASSIAVLAL 176
Cdd:PRK09584 101 GYALVAWSGHDAG------IVYMGMATIAVGNGLFKANPSSLLSTCYEKDDPRLDGA----FTMYYMSINIGSFFSMLAT 170
                        170       180
                 ....*....|....*....|....*...
gi 186511048 177 IFIQERVSWSLGFSIIAGSVVIAIVIFL 204
Cdd:PRK09584 171 PWLAAKYGWSVAFALSVVGMLITVVNFA 198
PRK10207 PRK10207
dipeptide/tripeptide permease DtpB;
22-204 4.97e-07

dipeptide/tripeptide permease DtpB;


Pssm-ID: 182306  Cd Length: 489  Bit Score: 52.51  E-value: 4.97e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048  22 IIVVEIAERFAFYGLASNLITFLTNELGQSTATAAKNINTWIGVSCMFPILGAFLADSILGRFKTVLLTSFIYLLGIVML 101
Cdd:PRK10207  19 IFFVELWERFGYYGVQGILAVFFVKQLGFSQEQAFITFGAFAALVYGLISIGGYVGDHLLGTKRTIVLGAIVLAIGYFMT 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 102 PLSVtvvarrMREKVFFMALYVMAVGEGGHKPCVMTFAADQFGEANAEEKAAKTSFfnywYMAIVLASSIAVLALIFIQE 181
Cdd:PRK10207  99 GMSL------LKPDLIFIALGTIAVGNGLFKANPASLLSKCYPPKDPRLDGAFTLF----YMSINIGSLISLSLAPVIAD 168
                        170       180
                 ....*....|....*....|...
gi 186511048 182 RVSWSLGFSIIAGSVVIAIVIFL 204
Cdd:PRK10207 169 KFGYSVTYNLCGAGLIIALLVYF 191
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
9-215 9.05e-07

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 51.13  E-value: 9.05e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048   9 NKRTKGGWNAALFIIVVEIAERFAFYGLASnLITFLTNELGQSTATAAKNINTWIGVSCMFPILGAFLADsILGRFKTVL 88
Cdd:COG2814    2 PATPRRRWLALLALALGAFLSGLGIGIVLP-ALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLAD-RFGRRRVLL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048  89 LTSFIYLLGIVMLPLSVTVVarrmrekVFFMALYVMAVGEGGHKPCVMTFAADQFGEANaeekaaKTSFFNYWYMAIVLA 168
Cdd:COG2814   80 LGLLLFALGSLLCALAPSLW-------LLLAARFLQGLGAGALFPAALALIADLVPPER------RGRALGLLGAGLGLG 146
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 186511048 169 SSIAVLALIFIQERVSWSLGFSIIAGSVVIAIVIFLIGIPKYRKQVP 215
Cdd:COG2814  147 PALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLLPESRPAAR 193
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
31-216 1.10e-06

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 51.03  E-value: 1.10e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048  31 FAFYGLASNLITFLTNELGQSTATAAkNINTWIGVSCMF-PILGAFLADSIlGRFKTVLLTSFIYLLGIVMLPLSVTVVA 109
Cdd:COG2223  219 GSFIGFSSWLPPYLVDQFGLSAATAG-LLAALFALLGALgRPLGGWLSDRI-GGRRVLLIVFALMALGLLLLALALGSLW 296
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 110 rrmrekVFFMALYVMAVGEGGHKPCVMTFAADQFGEANAeekAAKTSFFnywYMAIVLASSIAVLALIFIQERV-SWSLG 188
Cdd:COG2223  297 ------LFLVLFLLLGLALGGGNGAVFALVPDIFPTKNA---GAVYGLV---GAAGGLGGFLGPLLFGALLDATgSYTAA 364
                        170       180
                 ....*....|....*....|....*...
gi 186511048 189 FSIIAGSVVIAIVIFLIGIPKYRKQVPV 216
Cdd:COG2223  365 FLVFAVLALVALVLTLLLYRRPRRAAAA 392
MFS_1 pfam07690
Major Facilitator Superfamily;
31-219 3.32e-05

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 46.26  E-value: 3.32e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048   31 FAFYGLASNLITFLTNELGQSTATAAKNINTWIGVSCMFPILGAFLADsILGRFKTVLLTSFIYLLGIVMLPLSVTVVAr 110
Cdd:pfam07690  10 LGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSD-RFGRRRVLLIGLLLFALGLLLLLFASSLWL- 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048  111 rmrekvFFMALYVMAVGEGGHKPCVMTFAADQFGEANaeekaaKTSFFNYWYMAIVLASSIAVLALIFIQERVSWSLGFS 190
Cdd:pfam07690  88 ------LLVLRVLQGLGAGALFPAALALIADWFPPEE------RGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFL 155
                         170       180
                  ....*....|....*....|....*....
gi 186511048  191 IIAGSVVIAIVIFLIGIPKYRKQVPVGSP 219
Cdd:pfam07690 156 ILAILSLLAAVLLLLPRPPPESKRPKPAE 184
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
31-213 3.04e-04

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 43.30  E-value: 3.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048  31 FAFYGLASN----LITFLTNELGQSTATAAknintwIGVSCMF--PILGAFLADSILGRF---KTVLLTSFIYLLGIVML 101
Cdd:COG0738   17 FFLWGFATAlwgpLIPALKDAFGLSDAQAG------LLLFAFFlgYLLASLPAGRLIDRFgykRGLLLGLLLMALGLLLF 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 102 PLSVTVVarrmrekVFFMALYVMAVGEGghkpCVMTFAADQFGEANAEEKAAKTSFFNYWYMAIVLASSIAVLALIFIQE 181
Cdd:COG0738   91 ALAPSYP-------LLLLALFLLGLGLG----LLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGL 159
                        170       180       190
                 ....*....|....*....|....*....|...
gi 186511048 182 RVSWSLGFSIIAG-SVVIAIVIFLIGIPKYRKQ 213
Cdd:COG0738  160 SLSWHLPYLILAVlLLLLALLFLRSKLPEIEEE 192
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
20-207 3.73e-04

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 42.95  E-value: 3.73e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048  20 LFIIVVEIAERFAFYGLASNLITFLTNELGQSTATAAKnINTWIGVSCMF--PILGAfLADSIlGRFKTVLLTSFIYLLG 97
Cdd:cd17325  202 LALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGL-LFGAQGLASALsqPPAGK-LSDRI-GRKPLILIGLLLSAVA 278
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048  98 IVMLPLSVTVVArrmrekvFFMALYVMAVGEGGHKPCVMTFAADQFGEanaEEKAAKTSFFNywyMAIVLASSIAVLALI 177
Cdd:cd17325  279 LLLLPLATSFWL-------LLLLLALLGLGLGLVFPATLALLADIVPP---EGRGTAMGLFN---TAFSLGMVLGPLLGG 345
                        170       180       190
                 ....*....|....*....|....*....|
gi 186511048 178 FIQERVSWSLGFSIIAGSVVIAIVIFLIGI 207
Cdd:cd17325  346 FLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
31-204 3.86e-04

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 42.80  E-value: 3.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048  31 FAFYGLASNLITFLTNELGQSTATAAKNINTWIGVSCMFPILGAFLADSILGRFKTVLLTSFIYLLGIVMLPLSVTVvar 110
Cdd:cd06174  217 LAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSL--- 293
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 111 rmreKVFFMALYVMAVGEGGHKPCVMTFAADQFgeaNAEEKAAKTSFFNywyMAIVLASSIAVLALIFIQERV-SWSLGF 189
Cdd:cd06174  294 ----LLLLLLLLLLGFGLGGLLPLSFALIAELF---PPEIRGTAFGLLN---TFGFLGGAIGPLLAGFLLAATfGLTGAF 363
                        170
                 ....*....|....*
gi 186511048 190 SIIAGSVVIAIVIFL 204
Cdd:cd06174  364 LVLAVLLLLAAILLL 378
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
11-205 8.22e-04

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 41.78  E-value: 8.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048  11 RTKGGWNAALFIIVVEiaerFAFYGLASNLITFLTnELGQSTATAAkninTWIGVSCMFPILGAFLADSILGRFK----T 86
Cdd:COG2807  213 RSPLAWLLTLFFGLQS----LLYYAVVAWLPPILR-DAGLSAATAG----LLLSLFQLAGIPGSLLVPLLADRLGdrrpL 283
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048  87 VLLTSFIYLLGIVMLPLSVTVVArrmrekVFFMALyvMAVGEGGHKPCVMTFAADQFGeaNAEEKAAKTSFFnywYMAIV 166
Cdd:COG2807  284 LLLLGLLGLAGLLGLLLAPGSLP------WLWAVL--LGLGQGGLFPLALTLIGLRAR--TPAEAAALSGMA---QSVGY 350
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 186511048 167 LASSIAVLALIFIQERV-SWSLGFSIIAGSVVIAIVIFLI 205
Cdd:COG2807  351 LLAALGPLLVGALHDATgSWTAALLLLAALAVLMLVAGLL 390
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
31-236 1.04e-03

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 41.64  E-value: 1.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048  31 FAFYGLASNLITFLTNELGQSTATAAkNINTWIGVSCMF-PILGAFLADSIlGRFKTVLLTSFIYLLGIVMLPLSVTVVa 109
Cdd:cd06174    9 GLARGLISPLLPALLQSFGLSASQLG-LLFALFSLGYALlQPLAGLLADRF-GRRPVLLLGLLLFALGALLFAFAPSFW- 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048 110 rrmrekVFFMALYVMAVGEGGHKPCVMTFAADQFGEANaeekaaKTSFFNYWYMAIVLASSIAVLA--LIFIQERVSWSL 187
Cdd:cd06174   86 ------LLLLGRFLLGLGSGLIDPAVLALIADLFPERE------RGRALGLLQAFGSVGGILGPLLggILASSLGFGWRA 153
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 186511048 188 GFSIIAGSVVIAIVIFLIGI---PKYRKQVPVGSPFTRVAQVMVAALKKWRL 236
Cdd:cd06174  154 VFLIAAALALLAAILLLLVVpdpPESARAKNEEASSKSVLKLLKRVLKNPGL 205
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
2-235 1.72e-03

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 41.01  E-value: 1.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048   2 ADSTSLINKRTKGGWNAALFIIVVEIAERFAFYGLASnLITFLTNELGQSTATAAknINTWIGVSCMfpILGAFLADSIL 81
Cdd:COG2807    3 TTSSSARRSRRAGRWLLLLAIVLVALNLRPAITSVGP-LLPEIRADLGLSATQAG--LLTTLPLLAF--GLFAPLAPRLA 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048  82 GRF---KTVLLTSFIYLLGIVMLPLSVTVVArrmrekvfFMALYVMA-VGEGGHKPCVMTFAADQFgeanAEEKAAKTSF 157
Cdd:COG2807   78 RRFgleRTLLLALLLLAAGLLLRSLAPSVAL--------LLAGTALIgAGIAVGNVLLPGLIKRWF----PDRVGLMTGL 145
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 186511048 158 fnyWYMAIVLASSIAVLALIFIQERVSWSLGFSIIAGSVVIAIVIFLIGIpkyrKQVPVGSPFTRVAQVMVAALKKWR 235
Cdd:COG2807  146 ---YTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLL----RRRPAAAAAAPAAASLRSLWRSPL 216
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
20-148 2.07e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 40.34  E-value: 2.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048  20 LFIIVVEIAERFAFYGLASNLITFLTNELGQSTATAAKNINTWIGVSCMFPILGAFLADSIlGRFKTVLLTSFIYLLGIV 99
Cdd:COG2814  210 LLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRF-GRRRLLLIGLLLLALGLL 288
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 186511048 100 MLPLSVTVVArrmrekvFFMALYVMAVGEGGHKPCVMTFAADQFGEANA 148
Cdd:COG2814  289 LLALAGSLWL-------LLLALFLLGFGFGLLFPLLQALVAELAPPEAR 330
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
20-106 4.52e-03

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 39.51  E-value: 4.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186511048  20 LFIIVVEIAERFAFYGLASNLITFLTNELGQSTATAAkNINTWIGVSCMF-PILGAFLADSIlGRFKTVLLTSFIYLLGI 98
Cdd:cd17316  180 LLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSS-LYLLLISLGALVgALIAGLLSDRI-GRKKTLVIGLILSGILA 257

                 ....*...
gi 186511048  99 VMLPLSVT 106
Cdd:cd17316  258 LPLFYLLS 265
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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