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Conserved domains on  [gi|42572201|ref|NP_974191|]
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RNI-like superfamily protein [Arabidopsis thaliana]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
F-box_AtTIR1-like cd22159
F-box domain found in Arabidopsis thaliana transport inhibitor response 1 protein (TIR1), ...
14-53 1.81e-09

F-box domain found in Arabidopsis thaliana transport inhibitor response 1 protein (TIR1), coronatine-insensitive protein 1 (COI1) and similar proteins; TIR1, also called F-box/LRR-repeat protein 1 (FBL1), is part of an SCF (SKP1-cullin-F-box) protein ligase complex that promotes the ubiquitin-dependent proteolysis of a family of transcriptional regulators known as Aux/IAAs in an auxin-dependent manner. TIR1 is an auxin receptor that plays a potential role in plant hormone signaling. COI1, also called F-box/LRR-repeat protein 2 (FBL2), is the substrate-recruiting module of an SCF ubiquitin E3 ligase complex. It mediates jasmonate signalling by promoting hormone-dependent ubiquitylation and degradation of transcriptional repressor JASMONATE ZIM-domain (JAZ) family proteins. This subfamily also includes Arabidopsis thaliana EIN3-binding F-box protein 1 (EBF1). EBF1, also called F-box/LRR-repeat protein 6 (FBL6), is a component of the SCF(EBF1) E3 ubiquitin ligase complex, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins (probably including EIN3 and EIL1). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438930  Cd Length: 40  Bit Score: 52.85  E-value: 1.81e-09
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 42572201  14 MDELPDHLVWDILSKLHTTDDRNSLSLSCKRFFSLDNEQR 53
Cdd:cd22159   1 IDLLPDEILELIFSYLSDPWDRNSCSLVCKRWYRLERATR 40
AMN1 super family cl39120
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ...
25-200 2.08e-08

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.


The actual alignment was detected with superfamily member cd09293:

Pssm-ID: 187754 [Multi-domain]  Cd Length: 226  Bit Score: 54.64  E-value: 2.08e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572201  25 ILSKLHTTDDRNSLSLSCKRFfslDNEQRYSLRIgCGLVPASDALLSLCRrfpNLSKVEIIYSgwmsklgKQVDDQGLLV 104
Cdd:cd09293   7 ILHKLGQITQSNISQLLRILH---SGLEWLELYM-CPISDPPLDQLSNCN---KLKKLILPGS-------KLIDDEGLIA 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572201 105 LTTNCHSLTDLTLSFCTFITDVGIGHLS-SCPELSSLKLNFAPR---ITGCGVLSLAVGCKKLRRLHLIRClNV--ASVe 178
Cdd:cd09293  73 LAQSCPNLQVLDLRACENITDSGIVALAtNCPKLQTINLGRHRNghlITDVSLSALGKNCTFLQTVGFAGC-DVtdKGV- 150
                       170       180
                ....*....|....*....|..
gi 42572201 179 WLEYFGKLETLEELCIKNCRAI 200
Cdd:cd09293 151 WELASGCSKSLERLSLNNCRNL 172
AMN1 super family cl39120
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ...
241-435 6.00e-08

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.


The actual alignment was detected with superfamily member cd09293:

Pssm-ID: 187754 [Multi-domain]  Cd Length: 226  Bit Score: 53.49  E-value: 6.00e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572201 241 PKQLVPCDSLVELSLGNCIIAPGRGLACVLRNCKNLEKLHLDMCTGVSDSDIIALVQKASHLRSISLRVPSDFTLpllnn 320
Cdd:cd09293  45 LDQLSNCNKLKKLILPGSKLIDDEGLIALAQSCPNLQVLDLRACENITDSGIVALATNCPKLQTINLGRHRNGHL----- 119
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572201 321 itlrLTDESLSAIAQHCSKLESFKISFSDgefpslfsFTLQGIITLIQKCpvrelsldhvcvfndmgmealcsAQKLEIL 400
Cdd:cd09293 120 ----ITDVSLSALGKNCTFLQTVGFAGCD--------VTDKGVWELASGC-----------------------SKSLERL 164
                       170       180       190
                ....*....|....*....|....*....|....*...
gi 42572201 401 ELVHCQEVSDEGLILV---SQFPSLNVLKLSKCLGVTD 435
Cdd:cd09293 165 SLNNCRNLTDQSIPAIlasNYFPNLSVLEFRGCPLITD 202
 
Name Accession Description Interval E-value
F-box_AtTIR1-like cd22159
F-box domain found in Arabidopsis thaliana transport inhibitor response 1 protein (TIR1), ...
14-53 1.81e-09

F-box domain found in Arabidopsis thaliana transport inhibitor response 1 protein (TIR1), coronatine-insensitive protein 1 (COI1) and similar proteins; TIR1, also called F-box/LRR-repeat protein 1 (FBL1), is part of an SCF (SKP1-cullin-F-box) protein ligase complex that promotes the ubiquitin-dependent proteolysis of a family of transcriptional regulators known as Aux/IAAs in an auxin-dependent manner. TIR1 is an auxin receptor that plays a potential role in plant hormone signaling. COI1, also called F-box/LRR-repeat protein 2 (FBL2), is the substrate-recruiting module of an SCF ubiquitin E3 ligase complex. It mediates jasmonate signalling by promoting hormone-dependent ubiquitylation and degradation of transcriptional repressor JASMONATE ZIM-domain (JAZ) family proteins. This subfamily also includes Arabidopsis thaliana EIN3-binding F-box protein 1 (EBF1). EBF1, also called F-box/LRR-repeat protein 6 (FBL6), is a component of the SCF(EBF1) E3 ubiquitin ligase complex, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins (probably including EIN3 and EIL1). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438930  Cd Length: 40  Bit Score: 52.85  E-value: 1.81e-09
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 42572201  14 MDELPDHLVWDILSKLHTTDDRNSLSLSCKRFFSLDNEQR 53
Cdd:cd22159   1 IDLLPDEILELIFSYLSDPWDRNSCSLVCKRWYRLERATR 40
AMN1 cd09293
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ...
25-200 2.08e-08

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.


Pssm-ID: 187754 [Multi-domain]  Cd Length: 226  Bit Score: 54.64  E-value: 2.08e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572201  25 ILSKLHTTDDRNSLSLSCKRFfslDNEQRYSLRIgCGLVPASDALLSLCRrfpNLSKVEIIYSgwmsklgKQVDDQGLLV 104
Cdd:cd09293   7 ILHKLGQITQSNISQLLRILH---SGLEWLELYM-CPISDPPLDQLSNCN---KLKKLILPGS-------KLIDDEGLIA 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572201 105 LTTNCHSLTDLTLSFCTFITDVGIGHLS-SCPELSSLKLNFAPR---ITGCGVLSLAVGCKKLRRLHLIRClNV--ASVe 178
Cdd:cd09293  73 LAQSCPNLQVLDLRACENITDSGIVALAtNCPKLQTINLGRHRNghlITDVSLSALGKNCTFLQTVGFAGC-DVtdKGV- 150
                       170       180
                ....*....|....*....|..
gi 42572201 179 WLEYFGKLETLEELCIKNCRAI 200
Cdd:cd09293 151 WELASGCSKSLERLSLNNCRNL 172
AMN1 cd09293
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ...
241-435 6.00e-08

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.


Pssm-ID: 187754 [Multi-domain]  Cd Length: 226  Bit Score: 53.49  E-value: 6.00e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572201 241 PKQLVPCDSLVELSLGNCIIAPGRGLACVLRNCKNLEKLHLDMCTGVSDSDIIALVQKASHLRSISLRVPSDFTLpllnn 320
Cdd:cd09293  45 LDQLSNCNKLKKLILPGSKLIDDEGLIALAQSCPNLQVLDLRACENITDSGIVALATNCPKLQTINLGRHRNGHL----- 119
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572201 321 itlrLTDESLSAIAQHCSKLESFKISFSDgefpslfsFTLQGIITLIQKCpvrelsldhvcvfndmgmealcsAQKLEIL 400
Cdd:cd09293 120 ----ITDVSLSALGKNCTFLQTVGFAGCD--------VTDKGVWELASGC-----------------------SKSLERL 164
                       170       180       190
                ....*....|....*....|....*....|....*...
gi 42572201 401 ELVHCQEVSDEGLILV---SQFPSLNVLKLSKCLGVTD 435
Cdd:cd09293 165 SLNNCRNLTDQSIPAIlasNYFPNLSVLEFRGCPLITD 202
 
Name Accession Description Interval E-value
F-box_AtTIR1-like cd22159
F-box domain found in Arabidopsis thaliana transport inhibitor response 1 protein (TIR1), ...
14-53 1.81e-09

F-box domain found in Arabidopsis thaliana transport inhibitor response 1 protein (TIR1), coronatine-insensitive protein 1 (COI1) and similar proteins; TIR1, also called F-box/LRR-repeat protein 1 (FBL1), is part of an SCF (SKP1-cullin-F-box) protein ligase complex that promotes the ubiquitin-dependent proteolysis of a family of transcriptional regulators known as Aux/IAAs in an auxin-dependent manner. TIR1 is an auxin receptor that plays a potential role in plant hormone signaling. COI1, also called F-box/LRR-repeat protein 2 (FBL2), is the substrate-recruiting module of an SCF ubiquitin E3 ligase complex. It mediates jasmonate signalling by promoting hormone-dependent ubiquitylation and degradation of transcriptional repressor JASMONATE ZIM-domain (JAZ) family proteins. This subfamily also includes Arabidopsis thaliana EIN3-binding F-box protein 1 (EBF1). EBF1, also called F-box/LRR-repeat protein 6 (FBL6), is a component of the SCF(EBF1) E3 ubiquitin ligase complex, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins (probably including EIN3 and EIL1). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438930  Cd Length: 40  Bit Score: 52.85  E-value: 1.81e-09
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 42572201  14 MDELPDHLVWDILSKLHTTDDRNSLSLSCKRFFSLDNEQR 53
Cdd:cd22159   1 IDLLPDEILELIFSYLSDPWDRNSCSLVCKRWYRLERATR 40
AMN1 cd09293
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ...
25-200 2.08e-08

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.


Pssm-ID: 187754 [Multi-domain]  Cd Length: 226  Bit Score: 54.64  E-value: 2.08e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572201  25 ILSKLHTTDDRNSLSLSCKRFfslDNEQRYSLRIgCGLVPASDALLSLCRrfpNLSKVEIIYSgwmsklgKQVDDQGLLV 104
Cdd:cd09293   7 ILHKLGQITQSNISQLLRILH---SGLEWLELYM-CPISDPPLDQLSNCN---KLKKLILPGS-------KLIDDEGLIA 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572201 105 LTTNCHSLTDLTLSFCTFITDVGIGHLS-SCPELSSLKLNFAPR---ITGCGVLSLAVGCKKLRRLHLIRClNV--ASVe 178
Cdd:cd09293  73 LAQSCPNLQVLDLRACENITDSGIVALAtNCPKLQTINLGRHRNghlITDVSLSALGKNCTFLQTVGFAGC-DVtdKGV- 150
                       170       180
                ....*....|....*....|..
gi 42572201 179 WLEYFGKLETLEELCIKNCRAI 200
Cdd:cd09293 151 WELASGCSKSLERLSLNNCRNL 172
AMN1 cd09293
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ...
241-435 6.00e-08

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.


Pssm-ID: 187754 [Multi-domain]  Cd Length: 226  Bit Score: 53.49  E-value: 6.00e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572201 241 PKQLVPCDSLVELSLGNCIIAPGRGLACVLRNCKNLEKLHLDMCTGVSDSDIIALVQKASHLRSISLRVPSDFTLpllnn 320
Cdd:cd09293  45 LDQLSNCNKLKKLILPGSKLIDDEGLIALAQSCPNLQVLDLRACENITDSGIVALATNCPKLQTINLGRHRNGHL----- 119
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572201 321 itlrLTDESLSAIAQHCSKLESFKISFSDgefpslfsFTLQGIITLIQKCpvrelsldhvcvfndmgmealcsAQKLEIL 400
Cdd:cd09293 120 ----ITDVSLSALGKNCTFLQTVGFAGCD--------VTDKGVWELASGC-----------------------SKSLERL 164
                       170       180       190
                ....*....|....*....|....*....|....*...
gi 42572201 401 ELVHCQEVSDEGLILV---SQFPSLNVLKLSKCLGVTD 435
Cdd:cd09293 165 SLNNCRNLTDQSIPAIlasNYFPNLSVLEFRGCPLITD 202
AMN1 cd09293
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ...
94-150 7.16e-05

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.


Pssm-ID: 187754 [Multi-domain]  Cd Length: 226  Bit Score: 44.24  E-value: 7.16e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 42572201  94 GKQVDDQGLLVLTTNC-HSLTDLTLSFCTFITDVGIGHL---SSCPELSSLKLNFAPRITG 150
Cdd:cd09293 142 GCDVTDKGVWELASGCsKSLERLSLNNCRNLTDQSIPAIlasNYFPNLSVLEFRGCPLITD 202
AMN1 cd09293
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ...
353-450 1.67e-03

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.


Pssm-ID: 187754 [Multi-domain]  Cd Length: 226  Bit Score: 40.00  E-value: 1.67e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572201 353 PSLFSFTLQGIIT------LIQKCPVRELSLD-HVCVFNDMGMEALCSAQKLEILELVHCQEVSDEGLILVSQF-PSLNV 424
Cdd:cd09293   3 PLLFILHKLGQITqsnisqLLRILHSGLEWLElYMCPISDPPLDQLSNCNKLKKLILPGSKLIDDEGLIALAQScPNLQV 82
                        90       100
                ....*....|....*....|....*..
gi 42572201 425 LKLSKCLGVTDDGMRPLVGS-HKLELL 450
Cdd:cd09293  83 LDLRACENITDSGIVALATNcPKLQTI 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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