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Conserved domains on  [gi|42571533|ref|NP_973857|]
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Transmembrane Fragile-X-F-associated protein [Arabidopsis thaliana]

Protein Classification

TMEM185 family RING finger protein( domain architecture ID 10563171)

TMEM185 family protein with a RING finger domain similar to Arabidopsis thaliana transmembrane Fragile-X-F-associated protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tmemb_185A pfam10269
Transmembrane Fragile-X-F protein; This is a family of conserved transmembrane proteins that ...
 28-292 1.31e-105

Transmembrane Fragile-X-F protein; This is a family of conserved transmembrane proteins that appear in humans to be expressed from a region upstream of the FragileXF site and to be intimately linked with the Fragile-X syndrome. Absence of TMEM185A does not necessarily lead to developmental delay, but might in combination with other, yet unknown, factors. Otherwise, the lack of the TMEM185A protein is either disposable (redundant) or its function can be complemented by the highly similar chromosome 2 retro-pseudogene product, TMEM185B.


:

Pssm-ID: 402059  Cd Length: 245  Bit Score: 312.47  E-value: 1.31e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571533    28 LKLDHTVSSSWWMVFFPLWAFHAVVARGRF-------SLPAPvAPRNRHWAPCHAVVATPLLVAFELLLCIYLESSYARW 100
Cdd:pfam10269   1 LKLDHTVSWSWWKVFAPLWIFHALVARGRFvaaivwrSLPAS-RPEDRHWAPFHAVVATPLLLAFELLLCIYLESTYVGL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571533   101 PPAVSLKIAFLPLLAFELTILVDNLRMCRALMPGDDDSITDDAIWEALPHFWVAISMVFTLAATFFTLLKLSGDVVALGW 180
Cdd:pfam10269  80 SGALDWTIVFLPLLALEVVILVDNIRMCRALRPGDEESFSDEAIWETLPHFWVAISMVFFVAATTFTLLKLDGDVEALGW 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571533   181 WDLFINFGIAECFAFLVCTKWSNPVIHRSSRAREtgSSSTSIRYLDWNSglvvapeedrhqdrwcglqdigghMLKIPVI 260
Cdd:pfam10269 160 WDWFINFGVLYCFAFLVCTKWSNPVIASQSNISS--SSSTHIFYADWYS------------------------ILKIPLI 213

                         250       260       270
                  ....*....|....*....|....*....|..
gi 42571533   261 LFQVVLCMYLEGTPERAKDISIPVLFSPLFLL 292
Cdd:pfam10269 214 VFQVLLAAKLEGTPAAVADIPIAVVFAPLFLL 245
 
Name Accession Description Interval E-value
Tmemb_185A pfam10269
Transmembrane Fragile-X-F protein; This is a family of conserved transmembrane proteins that ...
 28-292 1.31e-105

Transmembrane Fragile-X-F protein; This is a family of conserved transmembrane proteins that appear in humans to be expressed from a region upstream of the FragileXF site and to be intimately linked with the Fragile-X syndrome. Absence of TMEM185A does not necessarily lead to developmental delay, but might in combination with other, yet unknown, factors. Otherwise, the lack of the TMEM185A protein is either disposable (redundant) or its function can be complemented by the highly similar chromosome 2 retro-pseudogene product, TMEM185B.


Pssm-ID: 402059  Cd Length: 245  Bit Score: 312.47  E-value: 1.31e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571533    28 LKLDHTVSSSWWMVFFPLWAFHAVVARGRF-------SLPAPvAPRNRHWAPCHAVVATPLLVAFELLLCIYLESSYARW 100
Cdd:pfam10269   1 LKLDHTVSWSWWKVFAPLWIFHALVARGRFvaaivwrSLPAS-RPEDRHWAPFHAVVATPLLLAFELLLCIYLESTYVGL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571533   101 PPAVSLKIAFLPLLAFELTILVDNLRMCRALMPGDDDSITDDAIWEALPHFWVAISMVFTLAATFFTLLKLSGDVVALGW 180
Cdd:pfam10269  80 SGALDWTIVFLPLLALEVVILVDNIRMCRALRPGDEESFSDEAIWETLPHFWVAISMVFFVAATTFTLLKLDGDVEALGW 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571533   181 WDLFINFGIAECFAFLVCTKWSNPVIHRSSRAREtgSSSTSIRYLDWNSglvvapeedrhqdrwcglqdigghMLKIPVI 260
Cdd:pfam10269 160 WDWFINFGVLYCFAFLVCTKWSNPVIASQSNISS--SSSTHIFYADWYS------------------------ILKIPLI 213

                         250       260       270
                  ....*....|....*....|....*....|..
gi 42571533   261 LFQVVLCMYLEGTPERAKDISIPVLFSPLFLL 292
Cdd:pfam10269 214 VFQVLLAAKLEGTPAAVADIPIAVVFAPLFLL 245
TMEM203 cd22816
Transmembrane protein 203; Transmembrane protein 203 (TMEM203) is a conserved putative ...
 19-48 6.29e-03

Transmembrane protein 203; Transmembrane protein 203 (TMEM203) is a conserved putative transmembrane protein that functions as a regulator of signaling pathways activated in response to diverse bacterial and viral stimuli. It has been shown in humans to be an intracellular regulator of STimulator of IFN Genes (STING)-mediated signaling and to interact with the pleiotropic inositol phosphate signaling pathway protein IP3R. In T-cells of patients with systemic lupus erythematosus (SLE), a disease characterized by the over-expression of type I interferons (IFN1), elevated TMEM203 mRNA levels are associated with disease activity. Thus, identification of TMEM203 may elucidate the control of STING-mediated innate immune responses, and provide a potential novel mechanism for therapeutic interventions in STING-associated inflammatory diseases.


Pssm-ID: 439364  Cd Length: 131  Bit Score: 36.90  E-value: 6.29e-03
                        10        20        30
                ....*....|....*....|....*....|
gi 42571533  19 LFCFTLLLVLKLDHTVSSSWWMVFFPLWAF 48
Cdd:cd22816  24 LLVFSVLLALKLEGHLSASWWTVFSPLFAA 53
 
Name Accession Description Interval E-value
Tmemb_185A pfam10269
Transmembrane Fragile-X-F protein; This is a family of conserved transmembrane proteins that ...
 28-292 1.31e-105

Transmembrane Fragile-X-F protein; This is a family of conserved transmembrane proteins that appear in humans to be expressed from a region upstream of the FragileXF site and to be intimately linked with the Fragile-X syndrome. Absence of TMEM185A does not necessarily lead to developmental delay, but might in combination with other, yet unknown, factors. Otherwise, the lack of the TMEM185A protein is either disposable (redundant) or its function can be complemented by the highly similar chromosome 2 retro-pseudogene product, TMEM185B.


Pssm-ID: 402059  Cd Length: 245  Bit Score: 312.47  E-value: 1.31e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571533    28 LKLDHTVSSSWWMVFFPLWAFHAVVARGRF-------SLPAPvAPRNRHWAPCHAVVATPLLVAFELLLCIYLESSYARW 100
Cdd:pfam10269   1 LKLDHTVSWSWWKVFAPLWIFHALVARGRFvaaivwrSLPAS-RPEDRHWAPFHAVVATPLLLAFELLLCIYLESTYVGL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571533   101 PPAVSLKIAFLPLLAFELTILVDNLRMCRALMPGDDDSITDDAIWEALPHFWVAISMVFTLAATFFTLLKLSGDVVALGW 180
Cdd:pfam10269  80 SGALDWTIVFLPLLALEVVILVDNIRMCRALRPGDEESFSDEAIWETLPHFWVAISMVFFVAATTFTLLKLDGDVEALGW 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571533   181 WDLFINFGIAECFAFLVCTKWSNPVIHRSSRAREtgSSSTSIRYLDWNSglvvapeedrhqdrwcglqdigghMLKIPVI 260
Cdd:pfam10269 160 WDWFINFGVLYCFAFLVCTKWSNPVIASQSNISS--SSSTHIFYADWYS------------------------ILKIPLI 213

                         250       260       270
                  ....*....|....*....|....*....|..
gi 42571533   261 LFQVVLCMYLEGTPERAKDISIPVLFSPLFLL 292
Cdd:pfam10269 214 VFQVLLAAKLEGTPAAVADIPIAVVFAPLFLL 245
TMEM203 cd22816
Transmembrane protein 203; Transmembrane protein 203 (TMEM203) is a conserved putative ...
 19-48 6.29e-03

Transmembrane protein 203; Transmembrane protein 203 (TMEM203) is a conserved putative transmembrane protein that functions as a regulator of signaling pathways activated in response to diverse bacterial and viral stimuli. It has been shown in humans to be an intracellular regulator of STimulator of IFN Genes (STING)-mediated signaling and to interact with the pleiotropic inositol phosphate signaling pathway protein IP3R. In T-cells of patients with systemic lupus erythematosus (SLE), a disease characterized by the over-expression of type I interferons (IFN1), elevated TMEM203 mRNA levels are associated with disease activity. Thus, identification of TMEM203 may elucidate the control of STING-mediated innate immune responses, and provide a potential novel mechanism for therapeutic interventions in STING-associated inflammatory diseases.


Pssm-ID: 439364  Cd Length: 131  Bit Score: 36.90  E-value: 6.29e-03
                        10        20        30
                ....*....|....*....|....*....|
gi 42571533  19 LFCFTLLLVLKLDHTVSSSWWMVFFPLWAF 48
Cdd:cd22816  24 LLVFSVLLALKLEGHLSASWWTVFSPLFAA 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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