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Conserved domains on  [gi|42571415|ref|NP_973798|]
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JmjC domain protein JMJ24 [Arabidopsis thaliana]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-4CXXC_R1 super family cl20401
Zinc-finger domain of monoamine-oxidase A repressor R1; R1 is a transcription factor repressor ...
 202-263 1.40e-11

Zinc-finger domain of monoamine-oxidase A repressor R1; R1 is a transcription factor repressor that inhibits monoamine oxidase A gene expression. This domain is a four-CXXC zinc finger putative DNA-binding domain found at the C-terminal end of R1. The domain carries 12 cysteines of which four pairs are of the CXXC type.


The actual alignment was detected with superfamily member pfam10497:

Pssm-ID: 463117  Cd Length: 99  Bit Score: 61.51  E-value: 1.40e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571415   202 LGEICHQCQRKDRERIISCL--KCN--QRAFCHNCLSARYSEIsLEEVEK----VCPACRGLCDCKSCLR 263
Cdd:pfam10497   5 NGKTCHQCRQKTLDTKTSCRnsQCKgvRGQFCGDCLRNRYGEN-VEEALAnpdwICPKCRGICNCSFCRK 73
WRC super family cl07468
WRC; The WRC domain, named after the conserved Trp-Arg-Cys motif, contains two distinctive ...
 25-65 5.39e-11

WRC; The WRC domain, named after the conserved Trp-Arg-Cys motif, contains two distinctive features: a putative nuclear localization signal and a zinc-finger motif (C3H). It is suggested that the WRC domain functions in DNA binding.


The actual alignment was detected with superfamily member pfam08879:

Pssm-ID: 462621  Cd Length: 42  Bit Score: 58.04  E-value: 5.39e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 42571415    25 PDDLRCKRSDGKQWRCTAMSMADKTVCEKHYIQAKKRAANS 65
Cdd:pfam08879   1 PEPGRCRRTDGKKWRCSRRVLPGQKLCERHMHRGRKRSNKS 41
cupin_RmlC-like super family cl40423
RmlC-like cupin superfamily; This superfamily contains proteins similar to the RmlC (dTDP ...
 738-842 9.76e-08

RmlC-like cupin superfamily; This superfamily contains proteins similar to the RmlC (dTDP (deoxythymidine diphosphates)-4-dehydrorhamnose 3,5-epimerase)-like cupins. RmlC is a dTDP-sugar isomerase involved in the synthesis of L-rhamnose, a saccharide required for the virulence of some pathogenic bacteria. Cupins are a functionally diverse superfamily originally discovered based on the highly conserved motif found in germin and germin-like proteins. This conserved motif forms a beta-barrel fold found in all of the cupins, giving rise to the name cupin ('cupa' is the Latin term for small barrel). The active site of members of this superfamily is generally located at the center of a conserved barrel and usually includes a metal ion. The different functional classes in this superfamily include single domain bacterial isomerases and epimerases involved in the modification of cell wall carbohydrates, two domain bicupins such as the desiccation-tolerant seed storage globulins, and multidomain nuclear transcription factors involved in legume root nodulation.


The actual alignment was detected with superfamily member pfam02373:

Pssm-ID: 477354  Cd Length: 114  Bit Score: 51.14  E-value: 9.76e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571415   738 MESSCTSScaggAQWDVFRRQDVPKLSGYLQRTFQKPDNIQTDFVSRPLYEGLFLNEHHKRQLRDEfGVEPWTFEQHRGE 817
Cdd:pfam02373  15 IEDQGLYS----INYLHFGAPKVWYIIPPEYAEKFEKVLSDHFGGEQPDDLLHLNTIISPKQLREN-GIPVYRFVQKPGE 89

                          90       100
                  ....*....|....*....|....*
gi 42571415   818 AIFIPAGCPFQITNLQSNIQVALDF 842
Cdd:pfam02373  90 FVFTFPGWYHQVFNLGFNIAEAVNF 114
JmjC smart00558
A domain family that is part of the cupin metalloenzyme superfamily; Probable enzymes, but of ...
 592-665 3.62e-03

A domain family that is part of the cupin metalloenzyme superfamily; Probable enzymes, but of unknown functions, that regulate chromatin reorganisation processes (Clissold and Ponting, in press).


:

Pssm-ID: 214721  Cd Length: 58  Bit Score: 36.46  E-value: 3.62e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 42571415    592 RPEFIRSFPFLeyihprlglLNVAAKLPHYSLQNDSGPkiYVSCGTYqeisagDSLTGIHYNMRDMVYLLVHTS 665
Cdd:smart00558   1 QLWNLAKLPFK---------LNLLSDLPEDIPGPDVGP--YLYMGMA------GSTTPWHIDDYDLVNYLHQGA 57
 
Name Accession Description Interval E-value
zf-4CXXC_R1 pfam10497
Zinc-finger domain of monoamine-oxidase A repressor R1; R1 is a transcription factor repressor ...
 202-263 1.40e-11

Zinc-finger domain of monoamine-oxidase A repressor R1; R1 is a transcription factor repressor that inhibits monoamine oxidase A gene expression. This domain is a four-CXXC zinc finger putative DNA-binding domain found at the C-terminal end of R1. The domain carries 12 cysteines of which four pairs are of the CXXC type.


Pssm-ID: 463117  Cd Length: 99  Bit Score: 61.51  E-value: 1.40e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571415   202 LGEICHQCQRKDRERIISCL--KCN--QRAFCHNCLSARYSEIsLEEVEK----VCPACRGLCDCKSCLR 263
Cdd:pfam10497   5 NGKTCHQCRQKTLDTKTSCRnsQCKgvRGQFCGDCLRNRYGEN-VEEALAnpdwICPKCRGICNCSFCRK 73
WRC pfam08879
WRC; The WRC domain, named after the conserved Trp-Arg-Cys motif, contains two distinctive ...
 25-65 5.39e-11

WRC; The WRC domain, named after the conserved Trp-Arg-Cys motif, contains two distinctive features: a putative nuclear localization signal and a zinc-finger motif (C3H). It is suggested that the WRC domain functions in DNA binding.


Pssm-ID: 462621  Cd Length: 42  Bit Score: 58.04  E-value: 5.39e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 42571415    25 PDDLRCKRSDGKQWRCTAMSMADKTVCEKHYIQAKKRAANS 65
Cdd:pfam08879   1 PEPGRCRRTDGKKWRCSRRVLPGQKLCERHMHRGRKRSNKS 41
JmjC pfam02373
JmjC domain, hydroxylase; The JmjC domain belongs to the Cupin superfamily. JmjC-domain ...
 738-842 9.76e-08

JmjC domain, hydroxylase; The JmjC domain belongs to the Cupin superfamily. JmjC-domain proteins may be protein hydroxylases that catalyze a novel histone modification. This is confirmed to be a hydroxylase: the human JmjC protein named Tyw5p unexpectedly acts in the biosynthesis of a hypermodified nucleoside, hydroxy-wybutosine, in tRNA-Phe by catalysing hydroxylation.


Pssm-ID: 396791  Cd Length: 114  Bit Score: 51.14  E-value: 9.76e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571415   738 MESSCTSScaggAQWDVFRRQDVPKLSGYLQRTFQKPDNIQTDFVSRPLYEGLFLNEHHKRQLRDEfGVEPWTFEQHRGE 817
Cdd:pfam02373  15 IEDQGLYS----INYLHFGAPKVWYIIPPEYAEKFEKVLSDHFGGEQPDDLLHLNTIISPKQLREN-GIPVYRFVQKPGE 89

                          90       100
                  ....*....|....*....|....*
gi 42571415   818 AIFIPAGCPFQITNLQSNIQVALDF 842
Cdd:pfam02373  90 FVFTFPGWYHQVFNLGFNIAEAVNF 114
JmjC smart00558
A domain family that is part of the cupin metalloenzyme superfamily; Probable enzymes, but of ...
 592-665 3.62e-03

A domain family that is part of the cupin metalloenzyme superfamily; Probable enzymes, but of unknown functions, that regulate chromatin reorganisation processes (Clissold and Ponting, in press).


Pssm-ID: 214721  Cd Length: 58  Bit Score: 36.46  E-value: 3.62e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 42571415    592 RPEFIRSFPFLeyihprlglLNVAAKLPHYSLQNDSGPkiYVSCGTYqeisagDSLTGIHYNMRDMVYLLVHTS 665
Cdd:smart00558   1 QLWNLAKLPFK---------LNLLSDLPEDIPGPDVGP--YLYMGMA------GSTTPWHIDDYDLVNYLHQGA 57
RING-HC_RNFT1 cd16741
RING finger, HC subclass, found in RING finger and transmembrane domain-containing protein 1 ...
 190-253 8.55e-03

RING finger, HC subclass, found in RING finger and transmembrane domain-containing protein 1 (RNFT1); RNFT1, also known as protein PTD016, is a multi-pass membrane protein containing a C3HC4-type RING-HC finger. Its biological role remains unclear.


Pssm-ID: 438399 [Multi-domain]  Cd Length: 58  Bit Score: 35.63  E-value: 8.55e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 42571415 190 YSAASTDVSAESLGEICHQCQRKDRERIIscLKCnQRAFCHNCLSARYSEisleevEKVCPACR 253
Cdd:cd16741   1 YGIAASKRQCSEADDICAICQAEFRKPIL--LIC-QHVFCEECISLWFNR------EKTCPLCR 55
 
Name Accession Description Interval E-value
zf-4CXXC_R1 pfam10497
Zinc-finger domain of monoamine-oxidase A repressor R1; R1 is a transcription factor repressor ...
 202-263 1.40e-11

Zinc-finger domain of monoamine-oxidase A repressor R1; R1 is a transcription factor repressor that inhibits monoamine oxidase A gene expression. This domain is a four-CXXC zinc finger putative DNA-binding domain found at the C-terminal end of R1. The domain carries 12 cysteines of which four pairs are of the CXXC type.


Pssm-ID: 463117  Cd Length: 99  Bit Score: 61.51  E-value: 1.40e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571415   202 LGEICHQCQRKDRERIISCL--KCN--QRAFCHNCLSARYSEIsLEEVEK----VCPACRGLCDCKSCLR 263
Cdd:pfam10497   5 NGKTCHQCRQKTLDTKTSCRnsQCKgvRGQFCGDCLRNRYGEN-VEEALAnpdwICPKCRGICNCSFCRK 73
WRC pfam08879
WRC; The WRC domain, named after the conserved Trp-Arg-Cys motif, contains two distinctive ...
 25-65 5.39e-11

WRC; The WRC domain, named after the conserved Trp-Arg-Cys motif, contains two distinctive features: a putative nuclear localization signal and a zinc-finger motif (C3H). It is suggested that the WRC domain functions in DNA binding.


Pssm-ID: 462621  Cd Length: 42  Bit Score: 58.04  E-value: 5.39e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 42571415    25 PDDLRCKRSDGKQWRCTAMSMADKTVCEKHYIQAKKRAANS 65
Cdd:pfam08879   1 PEPGRCRRTDGKKWRCSRRVLPGQKLCERHMHRGRKRSNKS 41
JmjC pfam02373
JmjC domain, hydroxylase; The JmjC domain belongs to the Cupin superfamily. JmjC-domain ...
 738-842 9.76e-08

JmjC domain, hydroxylase; The JmjC domain belongs to the Cupin superfamily. JmjC-domain proteins may be protein hydroxylases that catalyze a novel histone modification. This is confirmed to be a hydroxylase: the human JmjC protein named Tyw5p unexpectedly acts in the biosynthesis of a hypermodified nucleoside, hydroxy-wybutosine, in tRNA-Phe by catalysing hydroxylation.


Pssm-ID: 396791  Cd Length: 114  Bit Score: 51.14  E-value: 9.76e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571415   738 MESSCTSScaggAQWDVFRRQDVPKLSGYLQRTFQKPDNIQTDFVSRPLYEGLFLNEHHKRQLRDEfGVEPWTFEQHRGE 817
Cdd:pfam02373  15 IEDQGLYS----INYLHFGAPKVWYIIPPEYAEKFEKVLSDHFGGEQPDDLLHLNTIISPKQLREN-GIPVYRFVQKPGE 89

                          90       100
                  ....*....|....*....|....*
gi 42571415   818 AIFIPAGCPFQITNLQSNIQVALDF 842
Cdd:pfam02373  90 FVFTFPGWYHQVFNLGFNIAEAVNF 114
JmjC smart00558
A domain family that is part of the cupin metalloenzyme superfamily; Probable enzymes, but of ...
 592-665 3.62e-03

A domain family that is part of the cupin metalloenzyme superfamily; Probable enzymes, but of unknown functions, that regulate chromatin reorganisation processes (Clissold and Ponting, in press).


Pssm-ID: 214721  Cd Length: 58  Bit Score: 36.46  E-value: 3.62e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 42571415    592 RPEFIRSFPFLeyihprlglLNVAAKLPHYSLQNDSGPkiYVSCGTYqeisagDSLTGIHYNMRDMVYLLVHTS 665
Cdd:smart00558   1 QLWNLAKLPFK---------LNLLSDLPEDIPGPDVGP--YLYMGMA------GSTTPWHIDDYDLVNYLHQGA 57
RING-HC_RNFT1 cd16741
RING finger, HC subclass, found in RING finger and transmembrane domain-containing protein 1 ...
 190-253 8.55e-03

RING finger, HC subclass, found in RING finger and transmembrane domain-containing protein 1 (RNFT1); RNFT1, also known as protein PTD016, is a multi-pass membrane protein containing a C3HC4-type RING-HC finger. Its biological role remains unclear.


Pssm-ID: 438399 [Multi-domain]  Cd Length: 58  Bit Score: 35.63  E-value: 8.55e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 42571415 190 YSAASTDVSAESLGEICHQCQRKDRERIIscLKCnQRAFCHNCLSARYSEisleevEKVCPACR 253
Cdd:cd16741   1 YGIAASKRQCSEADDICAICQAEFRKPIL--LIC-QHVFCEECISLWFNR------EKTCPLCR 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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