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Conserved domains on  [gi|45433543|ref|NP_957384|]
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protein phosphatase, Mg2+/Mn2+ dependent, 1Da [Danio rerio]

Protein Classification

PP2C family serine/threonine-protein phosphatase( domain architecture ID 10065450)

PP2C family protein-serine/threonine phosphatase catalyzes the dephosphorylation of phosphoserine and phosphothreonine residues of specific protein substrates

CATH:  3.60.40.10
EC:  3.1.3.16
Gene Ontology:  GO:0004722|GO:0006470|GO:0046872
PubMed:  9192069|8819174
SCOP:  3000909

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PP2Cc cd00143
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and ...
98-375 3.39e-62

Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence similarity.


:

Pssm-ID: 238083 [Multi-domain]  Cd Length: 254  Bit Score: 204.48  E-value: 3.39e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45433543  98 VALFAVFDGHGGPDAARFARDHLWDHIKKQRGFWSE-DDDEVCAALRKGFITCHHAMWKKLPEWPKtvtglPSTSGTTAS 176
Cdd:cd00143  30 GGLFGVFDGHGGHAAGEFASKLLVEELLEELEETLTlSEEDIEEALRKAFLRADEEILEEAQDEPD-----DARSGTTAV 104
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45433543 177 IVVLRRDRMYVAHVGDSAVVLGVQDHpseefirAVEITQDHKPDLPKERERIEGLGGSVIkksgVNRVvwkrprlthngp 256
Cdd:cd00143 105 VALIRGNKLYVANVGDSRAVLCRNGE-------AVQLTKDHKPVNEEERERIEKAGGRVS----NGRV------------ 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45433543 257 vrrstvidqIPFLAVARALGDLWSYdfysgeFVVSPEPDTAVIKLDlKQHRYIILGSDGLWNMVSPQEAVSICQDNDEAK 336
Cdd:cd00143 162 ---------PGVLAVTRALGDFDLK------PGVSAEPDVTVVKLT-EDDDFLILASDGLWDVLSNQEAVDIVRSELAKE 225
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 45433543 337 AKNQKgnvsnAVLLVNHALLRWRQrmlraDNTSAIVISL 375
Cdd:cd00143 226 DLQEA-----AQELVDLALRRGSH-----DNITVVVVRL 254
 
Name Accession Description Interval E-value
PP2Cc cd00143
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and ...
98-375 3.39e-62

Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence similarity.


Pssm-ID: 238083 [Multi-domain]  Cd Length: 254  Bit Score: 204.48  E-value: 3.39e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45433543  98 VALFAVFDGHGGPDAARFARDHLWDHIKKQRGFWSE-DDDEVCAALRKGFITCHHAMWKKLPEWPKtvtglPSTSGTTAS 176
Cdd:cd00143  30 GGLFGVFDGHGGHAAGEFASKLLVEELLEELEETLTlSEEDIEEALRKAFLRADEEILEEAQDEPD-----DARSGTTAV 104
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45433543 177 IVVLRRDRMYVAHVGDSAVVLGVQDHpseefirAVEITQDHKPDLPKERERIEGLGGSVIkksgVNRVvwkrprlthngp 256
Cdd:cd00143 105 VALIRGNKLYVANVGDSRAVLCRNGE-------AVQLTKDHKPVNEEERERIEKAGGRVS----NGRV------------ 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45433543 257 vrrstvidqIPFLAVARALGDLWSYdfysgeFVVSPEPDTAVIKLDlKQHRYIILGSDGLWNMVSPQEAVSICQDNDEAK 336
Cdd:cd00143 162 ---------PGVLAVTRALGDFDLK------PGVSAEPDVTVVKLT-EDDDFLILASDGLWDVLSNQEAVDIVRSELAKE 225
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 45433543 337 AKNQKgnvsnAVLLVNHALLRWRQrmlraDNTSAIVISL 375
Cdd:cd00143 226 DLQEA-----AQELVDLALRRGSH-----DNITVVVVRL 254
PP2Cc smart00332
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and ...
99-373 9.22e-59

Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence similarity.


Pssm-ID: 214625 [Multi-domain]  Cd Length: 252  Bit Score: 195.29  E-value: 9.22e-59
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45433543     99 ALFAVFDGHGGPDAARFARDHLWDHIKKQRGFWSEDDDEVCAALRKGFITCHHAMWKKLPEwpktvtglpsTSGTTASIV 178
Cdd:smart00332  38 GFFGVFDGHGGSEAAKFLSKNLPEILAEELIKEKDELEDVEEALRKAFLSTDEEILEELEA----------LSGSTAVVA 107
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45433543    179 VLRRDRMYVAHVGDSAVVLGVQDhpseefiRAVEITQDHKPDLPKERERIEGLGGSVIKksgvNRVvwkrprlthngpvr 258
Cdd:smart00332 108 LISGNKLYVANVGDSRAVLCRNG-------KAVQLTEDHKPSNEDERARIEAAGGFVIN----GRV-------------- 162
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45433543    259 rstvidqIPFLAVARALGDLWSYdfysgeFVVSPEPDTAVIKLDlKQHRYIILGSDGLWNMVSPQEAVSICQDNDEAKAK 338
Cdd:smart00332 163 -------NGVLALSRAIGDFFLK------PYVSAEPDVTVVELT-EKDDFLILASDGLWDVLSNQEVVDIVRKHLSKDPK 228
                          250       260       270
                   ....*....|....*....|....*....|....*
gi 45433543    339 NQkgnvsnAVLLVNHALlrwrqRMLRADNTSAIVI 373
Cdd:smart00332 229 EA------AKRLIDLAL-----ARGSKDNITVVVV 252
PP2C pfam00481
Protein phosphatase 2C; Protein phosphatase 2C is a Mn++ or Mg++ dependent protein serine ...
83-368 7.07e-57

Protein phosphatase 2C; Protein phosphatase 2C is a Mn++ or Mg++ dependent protein serine/threonine phosphatase.


Pssm-ID: 395385  Cd Length: 252  Bit Score: 190.62  E-value: 7.07e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45433543    83 HASMPSSVHARRPRAVALFAVFDGHGGPDAARFARDHLWDHIKKQRGFWseDDDEVCAALRKGFItchhamwKKLPEWPK 162
Cdd:pfam00481  19 HIDLPNLNSSSGKDSWSFFAVFDGHGGSEAAKYCGKHLHTILALRRSFL--EGEKLEDALRKSFL-------EDTDEVLR 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45433543   163 TVTGLPSTSGTTASIVVLRRDRMYVAHVGDSAVVLGVQDHPseefirAVEITQDHKPDLPKERERIEGLGGSVIKksgVN 242
Cdd:pfam00481  90 SAEKEDLDSGCTAVVALISGNKLYVANVGDSRAVLCRNGNA------IKRLTKDHKPSDEDERRRIRAAGGFVSR---NG 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45433543   243 RVvwkrprlthNGpvrrstvidqipFLAVARALGDlwsYDFYSGEFVVSPEPDTAVIKLDlKQHRYIILGSDGLWNMVSP 322
Cdd:pfam00481 161 RV---------NG------------VLAVSRAFGD---FELKPGEQAVSAEPDITSHTIT-EDDEFLILACDGLWDVLSD 215
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 45433543   323 QEAVSICQDNDEAKAKNQKgnvsnavllVNHALLRWRQRMLRADNT 368
Cdd:pfam00481 216 QEVVDLVRSELSDGGSPME---------AAEELRDEAIAYGSEDNI 252
PLN03145 PLN03145
Protein phosphatase 2c; Provisional
99-377 1.00e-18

Protein phosphatase 2c; Provisional


Pssm-ID: 215603 [Multi-domain]  Cd Length: 365  Bit Score: 88.05  E-value: 1.00e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45433543   99 ALFAVFDGHGGPDAARFARDHLWDHIKKQRGFWSEDDDEVCAAlrkgFITCHHAMWKKLpewpkTVTGlPSTSGTTASIV 178
Cdd:PLN03145 104 AFYGVFDGHGGKHAADFACYHLPRFIVEDEDFPREIEKVVSSA----FLQTDTAFAEAC-----SLDA-SLASGTTALAA 173
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45433543  179 VLRRDRMYVAHVGDSAVVLGVQDhpseefiRAVEITQDHKPDLPKERERIEGLGGSVIKKsgvnrvvwkrprlTHNGpvr 258
Cdd:PLN03145 174 LVVGRSLVVANAGDCRAVLCRRG-------KAIEMSRDHKPMCSKERKRIEASGGYVYDG-------------YLNG--- 230
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45433543  259 rstvidqipFLAVARALGDlWSYDFYSGE--FVVSPEPDTAVIKLDlKQHRYIILGSDGLWNMVSPQEAVsicqdnDEAK 336
Cdd:PLN03145 231 ---------QLNVARALGD-WHMEGMKGSdgGPLSAEPELMTTQLT-EEDEFLIIGCDGIWDVFRSQNAV------DFAR 293
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 45433543  337 AKNQKGN--VSNAVLLVNHALLRwrqrmLRADNTSAIVISLES 377
Cdd:PLN03145 294 RRLQEHNdpVMCSKELVDEALKR-----KSGDNLAVVVVCFQS 331
PTC1 COG0631
Serine/threonine protein phosphatase PrpC [Signal transduction mechanisms];
89-382 2.03e-17

Serine/threonine protein phosphatase PrpC [Signal transduction mechanisms];


Pssm-ID: 440396 [Multi-domain]  Cd Length: 247  Bit Score: 81.80  E-value: 2.03e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45433543  89 SVHARRPRAVALFAVFDGHGGPD----AARFARDHLWDHIKKQrgfWSEDDDEVCAALRKGFITCHHAMWKKLPEWPKTv 164
Cdd:COG0631  19 AFLVALDPGGGLFVVADGMGGHAagevASRLAVETLAELFQEA---LAPDPEDLEEALREAIRAANRAILELAQEDPEL- 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45433543 165 tglpSTSGTTASIVVLRRDRMYVAHVGDSAVVLgVQDHpseEFIRaveITQDHkpdlpkererieglggSVikksgVNRV 244
Cdd:COG0631  95 ----AGMGTTLVAALIAGGRLYIAHVGDSRAYL-LRDG---ELEQ---LTRDH----------------SL-----VQEL 142
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45433543 245 VwKRPRLT----HNGPvRRStvidqipflAVARALGdlwsydfysgefvVSPEPDTAVIKLDLKQHRYIILGSDGLWNMV 320
Cdd:COG0631 143 V-DAGRITpeeaRTHP-QRN---------VLTRALG-------------TDDDVEPDISPLELEPGDRLLLCSDGLTDMV 198
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 45433543 321 SPQEAVSICQDNDEAKAKNQKgnvsnavlLVNHALlrwrqRMLRADNTSAIVISLESFGTSS 382
Cdd:COG0631 199 SDEEIAEILASAGDPQEAAEA--------LIELAL-----EAGGPDNITVVLVRVEDADAES 247
Stp1_PP2C_phos NF033484
Stp1/IreP family PP2C-type Ser/Thr phosphatase; Many Gram-positive bacteria have a protein ...
100-373 2.75e-09

Stp1/IreP family PP2C-type Ser/Thr phosphatase; Many Gram-positive bacteria have a protein kinase/protein phosphatase gene pair that responds to peptidoglycan metabolites and can be instrumental in resistance to beta-lactam antibiotics. Characterized examples of the phosphatase component are Stp1 of Staphylococcus aureus and IreP of Enterococcus faecalis.


Pssm-ID: 468046 [Multi-domain]  Cd Length: 232  Bit Score: 57.44  E-value: 2.75e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45433543  100 LFAVFDGHGGPD----AARFARDHLWDHIKKqrgfwsEDDDEVCAALRKGFITCHHAMWKKlpewpktvtglpSTS---- 171
Cdd:NF033484  26 LFIVADGMGGHNagevASRMAVETLGEYFEE------NEEEEIEEWLKEAIEEANEEIYEK------------AKEneel 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45433543  172 ---GTTASIVVLRRDRMYVAHVGDSAVVLgVQDhpsEEFIRaveITQDHkpdlpkererieglggsvikkSGVNRVVwKR 248
Cdd:NF033484  88 kgmGTTLVAALITDNKLYIAHVGDSRAYL-IRD---GELKQ---ITEDH---------------------SLVNELV-KS 138
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45433543  249 PRLTH----NGPvRRStVIdqipflavARALGdlwsydfysgefvVSP--EPDTavIKLDLKQHRYIILGSDGLWNMVSP 322
Cdd:NF033484 139 GEITEeearNHP-QKN-II--------TRALG-------------TEEdvEVDF--FEVELEEGDYLLLCSDGLTNMVSD 193
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 45433543  323 QEAVSICQDNDEAKAKNQKgnvsnavlLVNHAllrwrqrmLRA---DNTSAIVI 373
Cdd:NF033484 194 EEIEEILKSDNDLEEKAEK--------LIELA--------NENggkDNITVILI 231
 
Name Accession Description Interval E-value
PP2Cc cd00143
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and ...
98-375 3.39e-62

Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence similarity.


Pssm-ID: 238083 [Multi-domain]  Cd Length: 254  Bit Score: 204.48  E-value: 3.39e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45433543  98 VALFAVFDGHGGPDAARFARDHLWDHIKKQRGFWSE-DDDEVCAALRKGFITCHHAMWKKLPEWPKtvtglPSTSGTTAS 176
Cdd:cd00143  30 GGLFGVFDGHGGHAAGEFASKLLVEELLEELEETLTlSEEDIEEALRKAFLRADEEILEEAQDEPD-----DARSGTTAV 104
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45433543 177 IVVLRRDRMYVAHVGDSAVVLGVQDHpseefirAVEITQDHKPDLPKERERIEGLGGSVIkksgVNRVvwkrprlthngp 256
Cdd:cd00143 105 VALIRGNKLYVANVGDSRAVLCRNGE-------AVQLTKDHKPVNEEERERIEKAGGRVS----NGRV------------ 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45433543 257 vrrstvidqIPFLAVARALGDLWSYdfysgeFVVSPEPDTAVIKLDlKQHRYIILGSDGLWNMVSPQEAVSICQDNDEAK 336
Cdd:cd00143 162 ---------PGVLAVTRALGDFDLK------PGVSAEPDVTVVKLT-EDDDFLILASDGLWDVLSNQEAVDIVRSELAKE 225
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 45433543 337 AKNQKgnvsnAVLLVNHALLRWRQrmlraDNTSAIVISL 375
Cdd:cd00143 226 DLQEA-----AQELVDLALRRGSH-----DNITVVVVRL 254
PP2Cc smart00332
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and ...
99-373 9.22e-59

Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence similarity.


Pssm-ID: 214625 [Multi-domain]  Cd Length: 252  Bit Score: 195.29  E-value: 9.22e-59
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45433543     99 ALFAVFDGHGGPDAARFARDHLWDHIKKQRGFWSEDDDEVCAALRKGFITCHHAMWKKLPEwpktvtglpsTSGTTASIV 178
Cdd:smart00332  38 GFFGVFDGHGGSEAAKFLSKNLPEILAEELIKEKDELEDVEEALRKAFLSTDEEILEELEA----------LSGSTAVVA 107
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45433543    179 VLRRDRMYVAHVGDSAVVLGVQDhpseefiRAVEITQDHKPDLPKERERIEGLGGSVIKksgvNRVvwkrprlthngpvr 258
Cdd:smart00332 108 LISGNKLYVANVGDSRAVLCRNG-------KAVQLTEDHKPSNEDERARIEAAGGFVIN----GRV-------------- 162
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45433543    259 rstvidqIPFLAVARALGDLWSYdfysgeFVVSPEPDTAVIKLDlKQHRYIILGSDGLWNMVSPQEAVSICQDNDEAKAK 338
Cdd:smart00332 163 -------NGVLALSRAIGDFFLK------PYVSAEPDVTVVELT-EKDDFLILASDGLWDVLSNQEVVDIVRKHLSKDPK 228
                          250       260       270
                   ....*....|....*....|....*....|....*
gi 45433543    339 NQkgnvsnAVLLVNHALlrwrqRMLRADNTSAIVI 373
Cdd:smart00332 229 EA------AKRLIDLAL-----ARGSKDNITVVVV 252
PP2C pfam00481
Protein phosphatase 2C; Protein phosphatase 2C is a Mn++ or Mg++ dependent protein serine ...
83-368 7.07e-57

Protein phosphatase 2C; Protein phosphatase 2C is a Mn++ or Mg++ dependent protein serine/threonine phosphatase.


Pssm-ID: 395385  Cd Length: 252  Bit Score: 190.62  E-value: 7.07e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45433543    83 HASMPSSVHARRPRAVALFAVFDGHGGPDAARFARDHLWDHIKKQRGFWseDDDEVCAALRKGFItchhamwKKLPEWPK 162
Cdd:pfam00481  19 HIDLPNLNSSSGKDSWSFFAVFDGHGGSEAAKYCGKHLHTILALRRSFL--EGEKLEDALRKSFL-------EDTDEVLR 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45433543   163 TVTGLPSTSGTTASIVVLRRDRMYVAHVGDSAVVLGVQDHPseefirAVEITQDHKPDLPKERERIEGLGGSVIKksgVN 242
Cdd:pfam00481  90 SAEKEDLDSGCTAVVALISGNKLYVANVGDSRAVLCRNGNA------IKRLTKDHKPSDEDERRRIRAAGGFVSR---NG 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45433543   243 RVvwkrprlthNGpvrrstvidqipFLAVARALGDlwsYDFYSGEFVVSPEPDTAVIKLDlKQHRYIILGSDGLWNMVSP 322
Cdd:pfam00481 161 RV---------NG------------VLAVSRAFGD---FELKPGEQAVSAEPDITSHTIT-EDDEFLILACDGLWDVLSD 215
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 45433543   323 QEAVSICQDNDEAKAKNQKgnvsnavllVNHALLRWRQRMLRADNT 368
Cdd:pfam00481 216 QEVVDLVRSELSDGGSPME---------AAEELRDEAIAYGSEDNI 252
PLN03145 PLN03145
Protein phosphatase 2c; Provisional
99-377 1.00e-18

Protein phosphatase 2c; Provisional


Pssm-ID: 215603 [Multi-domain]  Cd Length: 365  Bit Score: 88.05  E-value: 1.00e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45433543   99 ALFAVFDGHGGPDAARFARDHLWDHIKKQRGFWSEDDDEVCAAlrkgFITCHHAMWKKLpewpkTVTGlPSTSGTTASIV 178
Cdd:PLN03145 104 AFYGVFDGHGGKHAADFACYHLPRFIVEDEDFPREIEKVVSSA----FLQTDTAFAEAC-----SLDA-SLASGTTALAA 173
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45433543  179 VLRRDRMYVAHVGDSAVVLGVQDhpseefiRAVEITQDHKPDLPKERERIEGLGGSVIKKsgvnrvvwkrprlTHNGpvr 258
Cdd:PLN03145 174 LVVGRSLVVANAGDCRAVLCRRG-------KAIEMSRDHKPMCSKERKRIEASGGYVYDG-------------YLNG--- 230
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45433543  259 rstvidqipFLAVARALGDlWSYDFYSGE--FVVSPEPDTAVIKLDlKQHRYIILGSDGLWNMVSPQEAVsicqdnDEAK 336
Cdd:PLN03145 231 ---------QLNVARALGD-WHMEGMKGSdgGPLSAEPELMTTQLT-EEDEFLIIGCDGIWDVFRSQNAV------DFAR 293
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 45433543  337 AKNQKGN--VSNAVLLVNHALLRwrqrmLRADNTSAIVISLES 377
Cdd:PLN03145 294 RRLQEHNdpVMCSKELVDEALKR-----KSGDNLAVVVVCFQS 331
PTC1 COG0631
Serine/threonine protein phosphatase PrpC [Signal transduction mechanisms];
89-382 2.03e-17

Serine/threonine protein phosphatase PrpC [Signal transduction mechanisms];


Pssm-ID: 440396 [Multi-domain]  Cd Length: 247  Bit Score: 81.80  E-value: 2.03e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45433543  89 SVHARRPRAVALFAVFDGHGGPD----AARFARDHLWDHIKKQrgfWSEDDDEVCAALRKGFITCHHAMWKKLPEWPKTv 164
Cdd:COG0631  19 AFLVALDPGGGLFVVADGMGGHAagevASRLAVETLAELFQEA---LAPDPEDLEEALREAIRAANRAILELAQEDPEL- 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45433543 165 tglpSTSGTTASIVVLRRDRMYVAHVGDSAVVLgVQDHpseEFIRaveITQDHkpdlpkererieglggSVikksgVNRV 244
Cdd:COG0631  95 ----AGMGTTLVAALIAGGRLYIAHVGDSRAYL-LRDG---ELEQ---LTRDH----------------SL-----VQEL 142
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45433543 245 VwKRPRLT----HNGPvRRStvidqipflAVARALGdlwsydfysgefvVSPEPDTAVIKLDLKQHRYIILGSDGLWNMV 320
Cdd:COG0631 143 V-DAGRITpeeaRTHP-QRN---------VLTRALG-------------TDDDVEPDISPLELEPGDRLLLCSDGLTDMV 198
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 45433543 321 SPQEAVSICQDNDEAKAKNQKgnvsnavlLVNHALlrwrqRMLRADNTSAIVISLESFGTSS 382
Cdd:COG0631 199 SDEEIAEILASAGDPQEAAEA--------LIELAL-----EAGGPDNITVVLVRVEDADAES 247
PTZ00224 PTZ00224
protein phosphatase 2C; Provisional
98-345 5.21e-16

protein phosphatase 2C; Provisional


Pssm-ID: 240318 [Multi-domain]  Cd Length: 381  Bit Score: 79.82  E-value: 5.21e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45433543   98 VALFAVFDGHGGPDAARFARDHLWDHIKKQRGFWSEDD-DEVCAALRKGFITCHHAmwkklpewpktvtglpstSGTTAS 176
Cdd:PTZ00224  48 WGFFGVFDGHVNDECSQYLARAWPQALEKEPEPMTDERmEELCLEIDEEWMDSGRE------------------GGSTGT 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45433543  177 IVVLRRD-RMYVAHVGDSAVVLGVQDhpseefiRAVEITQDHKPDLPKERERIEGLGGSVIKksgvNRVvwkrprlthNG 255
Cdd:PTZ00224 110 FCVIMKDvHLQVGNVGDSRVLVCRDG-------KLVFATEDHKPNNPGERQRIEACGGRVVS----NRV---------DG 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45433543  256 PvrrstvidqipfLAVARALGD----LWSYDFYSGEFVVsPEPDtaVIKLDLKQHRYIILGSDGLWNMVSPQE------- 324
Cdd:PTZ00224 170 D------------LAVSRAFGDrsfkVKGTGDYLEQKVI-AVPD--VTHLTCQSNDFIILACDGVFEGNFSNEevvafvk 234
                        250       260       270
                 ....*....|....*....|....*....|
gi 45433543  325 ---------AVSICQDNDEAKAKNQKGNVS 345
Cdd:PTZ00224 235 eqletcddlAVVAGRVCDEAIRRGSKDNIS 264
Stp1_PP2C_phos NF033484
Stp1/IreP family PP2C-type Ser/Thr phosphatase; Many Gram-positive bacteria have a protein ...
100-373 2.75e-09

Stp1/IreP family PP2C-type Ser/Thr phosphatase; Many Gram-positive bacteria have a protein kinase/protein phosphatase gene pair that responds to peptidoglycan metabolites and can be instrumental in resistance to beta-lactam antibiotics. Characterized examples of the phosphatase component are Stp1 of Staphylococcus aureus and IreP of Enterococcus faecalis.


Pssm-ID: 468046 [Multi-domain]  Cd Length: 232  Bit Score: 57.44  E-value: 2.75e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45433543  100 LFAVFDGHGGPD----AARFARDHLWDHIKKqrgfwsEDDDEVCAALRKGFITCHHAMWKKlpewpktvtglpSTS---- 171
Cdd:NF033484  26 LFIVADGMGGHNagevASRMAVETLGEYFEE------NEEEEIEEWLKEAIEEANEEIYEK------------AKEneel 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45433543  172 ---GTTASIVVLRRDRMYVAHVGDSAVVLgVQDhpsEEFIRaveITQDHkpdlpkererieglggsvikkSGVNRVVwKR 248
Cdd:NF033484  88 kgmGTTLVAALITDNKLYIAHVGDSRAYL-IRD---GELKQ---ITEDH---------------------SLVNELV-KS 138
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45433543  249 PRLTH----NGPvRRStVIdqipflavARALGdlwsydfysgefvVSP--EPDTavIKLDLKQHRYIILGSDGLWNMVSP 322
Cdd:NF033484 139 GEITEeearNHP-QKN-II--------TRALG-------------TEEdvEVDF--FEVELEEGDYLLLCSDGLTNMVSD 193
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 45433543  323 QEAVSICQDNDEAKAKNQKgnvsnavlLVNHAllrwrqrmLRA---DNTSAIVI 373
Cdd:NF033484 194 EEIEEILKSDNDLEEKAEK--------LIELA--------NENggkDNITVILI 231
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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