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Conserved domains on  [gi|41053569|ref|NP_956586|]
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periodic tryptophan protein 1 homolog [Danio rerio]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 250-412 5.16e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 115.90  E-value: 5.16e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053569 250 IEGHTDAVLDLSWNRlVRNVLASASADETVILWDLEKGKPAATLAKHTDKVQTLKFHPfEAQTLISGSFDKSVILYDCRS 329
Cdd:cd00200 131 LRGHTDWVNSVAFSP-DGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLST 208

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053569 330 PDDSHriwRFSGQVERVTWDHFSPCN--FLASTEDGFIYCLDARSDKPVFTLRAHDGEVSGMDLSSQIrGCLVTCSADKH 407
Cdd:cd00200 209 GKCLG---TLRGHENGVNSVAFSPDGylLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDG-KRLASGSADGT 284


                ....*
gi 41053569 408 VKIWD 412
Cdd:cd00200 285 IRIWD 289
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 375-469 7.92e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 44.63  E-value: 7.92e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053569 375 PVFTLRAHDGEVSGMDLSSQIRGcLVTCSADKHVKIWDILGNKP---NLIHSRdmkmGVLFCgSCCPDLPFVYAfGGQRE 451
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKL-LATGSGDGTIKVWDLETGELlrtLKGHTG----PVRDV-AASADGTYLAS-GSSDK 73

                        90
                ....*....|....*...
gi 41053569 452 GLRVWDISDVAAVAEVFG 469
Cdd:cd00200  74 TIRLWDLETGECVRTLTG 91
WD40 super family cl43672
WD40 repeat [General function prediction only];
202-285 1.69e-03

WD40 repeat [General function prediction only];


The actual alignment was detected with superfamily member COG2319:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 40.66  E-value: 1.69e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053569 202 GNYAAVGNMTPVIDVWDLDVVDCLepafslgskkekkkkkkakkaaEPIEGHTDAVLDLSWNRlVRNVLASASADETVIL 281
Cdd:COG2319 342 GKTLASGSDDGTVRLWDLATGELL----------------------RTLTGHTGAVTSVAFSP-DGRTLASGSADGTVRL 398


                ....
gi 41053569 282 WDLE 285
Cdd:COG2319 399 WDLA 402
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 250-412 5.16e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 115.90  E-value: 5.16e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053569 250 IEGHTDAVLDLSWNRlVRNVLASASADETVILWDLEKGKPAATLAKHTDKVQTLKFHPfEAQTLISGSFDKSVILYDCRS 329
Cdd:cd00200 131 LRGHTDWVNSVAFSP-DGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLST 208

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053569 330 PDDSHriwRFSGQVERVTWDHFSPCN--FLASTEDGFIYCLDARSDKPVFTLRAHDGEVSGMDLSSQIrGCLVTCSADKH 407
Cdd:cd00200 209 GKCLG---TLRGHENGVNSVAFSPDGylLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDG-KRLASGSADGT 284


                ....*
gi 41053569 408 VKIWD 412
Cdd:cd00200 285 IRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
249-486 2.48e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 116.16  E-value: 2.48e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053569 249 PIEGHTDAVLDLSWN---RLvrnvLASASADETVILWDLEKGKPAATLAKHTDKVQTLKFHPfEAQTLISGSFDKSVILY 325
Cdd:COG2319 157 TLTGHSGAVTSVAFSpdgKL----LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLW 231

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053569 326 DCRSPDDSHRIWRFSGQVERVTwdhFSP-CNFLAST-EDGFIYCLDARSDKPVFTLRAHDGEVSGMDLS--SQIrgcLVT 401
Cdd:COG2319 232 DLATGKLLRTLTGHSGSVRSVA---FSPdGRLLASGsADGTVRLWDLATGELLRTLTGHSGGVNSVAFSpdGKL---LAS 305

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053569 402 CSADKHVKIWDIlgNKPNLIHSRDMKMGVLFCGSCCPDLPFVyAFGGQREGLRVWDISDVAAVAEVFGSRERLVANTVSG 481
Cdd:COG2319 306 GSDDGTVRLWDL--ATGKLLRTLTGHTGAVRSVAFSPDGKTL-ASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP 382

                       250
                ....*....|
gi 41053569 482 -----ASSSD 486
Cdd:COG2319 383 dgrtlASGSA 392
PTZ00420 PTZ00420
coronin; Provisional
 250-384 6.95e-08

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 54.96  E-value: 6.95e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053569  250 IEGHTDAVLDLSWNRLVRNVLASASADETVILWDL--------EKGKPAATLAKHTDKVQTLKFHPFEAQTLISGSFDKS 321
Cdd:PTZ00420  70 LKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIphndesvkEIKDPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSF 149

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 41053569  322 VILYDCRSPDDSHRIwRFSGQVERVTWDhfSPCNFLASTEDG-FIYCLDARSDKPVFTLRAHDG 384
Cdd:PTZ00420 150 VNIWDIENEKRAFQI-NMPKKLSSLKWN--IKGNLLSGTCVGkHMHIIDPRKQEIASSFHIHDG 210
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 372-412 4.94e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 4.94e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 41053569    372 SDKPVFTLRAHDGEVSGMDLSSQIRgCLVTCSADKHVKIWD 412
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGK-YLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
374-412 5.96e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 5.96e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 41053569   374 KPVFTLRAHDGEVSGMDLSSQiRGCLVTCSADKHVKIWD 412
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPD-GKLLASGSDDGTVKVWD 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 375-469 7.92e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 44.63  E-value: 7.92e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053569 375 PVFTLRAHDGEVSGMDLSSQIRGcLVTCSADKHVKIWDILGNKP---NLIHSRdmkmGVLFCgSCCPDLPFVYAfGGQRE 451
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKL-LATGSGDGTIKVWDLETGELlrtLKGHTG----PVRDV-AASADGTYLAS-GSSDK 73

                        90
                ....*....|....*...
gi 41053569 452 GLRVWDISDVAAVAEVFG 469
Cdd:cd00200  74 TIRLWDLETGECVRTLTG 91
WD40 COG2319
WD40 repeat [General function prediction only];
202-285 1.69e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 40.66  E-value: 1.69e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053569 202 GNYAAVGNMTPVIDVWDLDVVDCLepafslgskkekkkkkkakkaaEPIEGHTDAVLDLSWNRlVRNVLASASADETVIL 281
Cdd:COG2319 342 GKTLASGSDDGTVRLWDLATGELL----------------------RTLTGHTGAVTSVAFSP-DGRTLASGSADGTVRL 398


                ....
gi 41053569 282 WDLE 285
Cdd:COG2319 399 WDLA 402
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 250-412 5.16e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 115.90  E-value: 5.16e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053569 250 IEGHTDAVLDLSWNRlVRNVLASASADETVILWDLEKGKPAATLAKHTDKVQTLKFHPfEAQTLISGSFDKSVILYDCRS 329
Cdd:cd00200 131 LRGHTDWVNSVAFSP-DGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLST 208

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053569 330 PDDSHriwRFSGQVERVTWDHFSPCN--FLASTEDGFIYCLDARSDKPVFTLRAHDGEVSGMDLSSQIrGCLVTCSADKH 407
Cdd:cd00200 209 GKCLG---TLRGHENGVNSVAFSPDGylLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDG-KRLASGSADGT 284


                ....*
gi 41053569 408 VKIWD 412
Cdd:cd00200 285 IRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
249-486 2.48e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 116.16  E-value: 2.48e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053569 249 PIEGHTDAVLDLSWN---RLvrnvLASASADETVILWDLEKGKPAATLAKHTDKVQTLKFHPfEAQTLISGSFDKSVILY 325
Cdd:COG2319 157 TLTGHSGAVTSVAFSpdgKL----LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLW 231

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053569 326 DCRSPDDSHRIWRFSGQVERVTwdhFSP-CNFLAST-EDGFIYCLDARSDKPVFTLRAHDGEVSGMDLS--SQIrgcLVT 401
Cdd:COG2319 232 DLATGKLLRTLTGHSGSVRSVA---FSPdGRLLASGsADGTVRLWDLATGELLRTLTGHSGGVNSVAFSpdGKL---LAS 305

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053569 402 CSADKHVKIWDIlgNKPNLIHSRDMKMGVLFCGSCCPDLPFVyAFGGQREGLRVWDISDVAAVAEVFGSRERLVANTVSG 481
Cdd:COG2319 306 GSDDGTVRLWDL--ATGKLLRTLTGHTGAVRSVAFSPDGKTL-ASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP 382

                       250
                ....*....|
gi 41053569 482 -----ASSSD 486
Cdd:COG2319 383 dgrtlASGSA 392
WD40 COG2319
WD40 repeat [General function prediction only];
249-460 4.62e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 112.70  E-value: 4.62e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053569 249 PIEGHTDAVLDLSWNRlVRNVLASASADETVILWDLEKGKPAATLAKHTDKVQTLKFHPfEAQTLISGSFDKSVILYDCR 328
Cdd:COG2319 115 TLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSP-DGKLLASGSDDGTVRLWDLA 192

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053569 329 SPDdshRIWRFSGQVERVTWDHFSPC-NFLAS-TEDGFIYCLDARSDKPVFTLRAHDGEVSGMDLS--SQIrgcLVTCSA 404
Cdd:COG2319 193 TGK---LLRTLTGHTGAVRSVAFSPDgKLLASgSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSpdGRL---LASGSA 266

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 41053569 405 DKHVKIWDILGNKpnLIHSRDMKMGVLFCGSCCPDLPFVyAFGGQREGLRVWDISD 460
Cdd:COG2319 267 DGTVRLWDLATGE--LLRTLTGHSGGVNSVAFSPDGKLL-ASGSDDGTVRLWDLAT 319
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 250-488 1.19e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 108.96  E-value: 1.19e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053569 250 IEGHTDAVLDLSWNRlVRNVLASASADETVILWDLEKGKPAATLAKHTDKVQTLKFHPFeAQTLISGSFDKSVILYDcrs 329
Cdd:cd00200   5 LKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASAD-GTYLASGSSDKTIRLWD--- 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053569 330 PDDSHRIWRFSGQVERVTWDHFSPCNFLAST--EDGFIYCLDARSDKPVFTLRAHDGEVSGMDLSSQiRGCLVTCSADKH 407
Cdd:cd00200  80 LETGECVRTLTGHTSYVSSVAFSPDGRILSSssRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD-GTFVASSSQDGT 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053569 408 VKIWDILGNKPNLIHSrDMKMGVLFCgSCCPDLPFVYAFGGQREgLRVWDISDVAAVAEVFGSRERLVANTVSG----AS 483
Cdd:cd00200 159 IKLWDLRTGKCVATLT-GHTGEVNSV-AFSPDGEKLLSSSSDGT-IKLWDLSTGKCLGTLRGHENGVNSVAFSPdgylLA 235


                ....*
gi 41053569 484 SSDMD 488
Cdd:cd00200 236 SGSED 240
WD40 COG2319
WD40 repeat [General function prediction only];
181-413 1.55e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 111.16  E-value: 1.55e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053569 181 LPAYPLCVEWLNFDPNpeeqqGNYAAVGNMTPVIDVWDLDVVDCLepafslgskkekkkkkkakkaaEPIEGHTDAVLDL 260
Cdd:COG2319 200 LTGHTGAVRSVAFSPD-----GKLLASGSADGTVRLWDLATGKLL----------------------RTLTGHSGSVRSV 252

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053569 261 SWN---RLvrnvLASASADETVILWDLEKGKPAATLAKHTDKVQTLKFHPfEAQTLISGSFDKSVILYDcrsPDDSHRIW 337
Cdd:COG2319 253 AFSpdgRL----LASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSP-DGKLLASGSDDGTVRLWD---LATGKLLR 324

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 41053569 338 RFSGQVERVTWDHFSPC-NFLAS-TEDGFIYCLDARSDKPVFTLRAHDGEVSGMDLSSQirGC-LVTCSADKHVKIWDI 413
Cdd:COG2319 325 TLTGHTGAVRSVAFSPDgKTLASgSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPD--GRtLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 251-476 1.47e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 103.18  E-value: 1.47e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053569 251 EGHTDAVLDLSWnRLVRNVLASASADETVILWDLEKGKPAATLAKHTDKVQTLKFHPfEAQTLISGSFDKSVILYDCRSP 330
Cdd:cd00200  48 KGHTGPVRDVAA-SADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETG 125

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053569 331 DDSHRIWRFSGQVERVTWDHFSpcNFLA-STEDGFIYCLDARSDKPVFTLRAHDGEVSGMDLSSQiRGCLVTCSADKHVK 409
Cdd:cd00200 126 KCLTTLRGHTDWVNSVAFSPDG--TFVAsSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPD-GEKLLSSSSDGTIK 202

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 41053569 410 IWDIlgnkpnlihSRDMKMGVL-----FCGSCCPDLPFVYAFGGQREG-LRVWDISDVAAVAEVFGSRERLVA 476
Cdd:cd00200 203 LWDL---------STGKCLGTLrghenGVNSVAFSPDGYLLASGSEDGtIRVWDLRTGECVQTLSGHTNSVTS 266
WD40 COG2319
WD40 repeat [General function prediction only];
228-460 1.38e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 102.68  E-value: 1.38e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053569 228 AFSLGSKKEKKKKKKAKKAAEPIEGHTDAVLDLSWNRLVRnVLASASADETVILWDLEKGKPAATLAKHTDKVQTLKFHP 307
Cdd:COG2319  52 AAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGR-LLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSP 130

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053569 308 fEAQTLISGSFDKSVILYDcrsPDDSHRIWRFSGQVERVTWDHFSP-CNFLAST-EDGFIYCLDARSDKPVFTLRAHDGE 385
Cdd:COG2319 131 -DGKTLASGSADGTVRLWD---LATGKLLRTLTGHSGAVTSVAFSPdGKLLASGsDDGTVRLWDLATGKLLRTLTGHTGA 206

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 41053569 386 VSGMDLS--SQIrgcLVTCSADKHVKIWDILGNKP--NLIHSRDMKMGVLFcgSccPDLPFVyAFGGQREGLRVWDISD 460
Cdd:COG2319 207 VRSVAFSpdGKL---LASGSADGTVRLWDLATGKLlrTLTGHSGSVRSVAF--S--PDGRLL-ASGSADGTVRLWDLAT 277
WD40 COG2319
WD40 repeat [General function prediction only];
251-465 2.45e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 83.81  E-value: 2.45e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053569 251 EGHTDAVLDLSWNRLVRnVLASASADETVILWDLEKGKPAATLAKHTDKVQTLKFHPfEAQTLISGSFDKSVILYDCRSP 330
Cdd:COG2319  33 LGLAAAVASLAASPDGA-RLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSP-DGRLLASASADGTVRLWDLATG 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053569 331 DDSHRIWRFSGQVERVTwdhFSP-CNFLAST-EDGFIYCLDARSDKPVFTLRAHDGEVSGMDLS--SQIrgcLVTCSADK 406
Cdd:COG2319 111 LLLRTLTGHTGAVRSVA---FSPdGKTLASGsADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSpdGKL---LASGSDDG 184

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 41053569 407 HVKIWDILGNKpnLIHSRDMKMGVLFCGSCCPDLPFVyAFGGQREGLRVWDISDVAAVA 465
Cdd:COG2319 185 TVRLWDLATGK--LLRTLTGHTGAVRSVAFSPDGKLL-ASGSADGTVRLWDLATGKLLR 240
PTZ00420 PTZ00420
coronin; Provisional
 250-384 6.95e-08

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 54.96  E-value: 6.95e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053569  250 IEGHTDAVLDLSWNRLVRNVLASASADETVILWDL--------EKGKPAATLAKHTDKVQTLKFHPFEAQTLISGSFDKS 321
Cdd:PTZ00420  70 LKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIphndesvkEIKDPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSF 149

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 41053569  322 VILYDCRSPDDSHRIwRFSGQVERVTWDhfSPCNFLASTEDG-FIYCLDARSDKPVFTLRAHDG 384
Cdd:PTZ00420 150 VNIWDIENEKRAFQI-NMPKKLSSLKWN--IKGNLLSGTCVGkHMHIIDPRKQEIASSFHIHDG 210
PTZ00421 PTZ00421
coronin; Provisional
 250-348 1.64e-07

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 53.74  E-value: 1.64e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053569  250 IEGHTDAVLDLSWNRLVRNVLASASADETVILWDLEKGKPAATLAKHTDKVQTLKFHpFEAQTLISGSFDKSVILYDCRS 329
Cdd:PTZ00421 121 LQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWN-LDGSLLCTTSKDKKLNIIDPRD 199

                         90       100
                 ....*....|....*....|....
gi 41053569  330 PD-----DSHRiwrfSGQVERVTW 348
Cdd:PTZ00421 200 GTivssvEAHA----SAKSQRCLW 219
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 260-413 3.35e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 49.70  E-value: 3.35e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053569  260 LSWNRLVRNVLASASADETVILWDLEKGKPAATLAKHTDKVQTLKFHPFEAQTLISGSFDKSVILYDCRSPDDSHRIwRF 339
Cdd:PLN00181 538 ICWNSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTI-KT 616

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 41053569  340 SGQVERVTWDHFSPCNFLASTEDGFIYCLDARSDK-PVFTLRAHDGEVSGMDLSSQirGCLVTCSADKHVKIWDI 413
Cdd:PLN00181 617 KANICCVQFPSESGRSLAFGSADHKVYYYDLRNPKlPLCTMIGHSKTVSYVRFVDS--STLVSSSTDNTLKLWDL 689
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 372-412 4.94e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 4.94e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 41053569    372 SDKPVFTLRAHDGEVSGMDLSSQIRgCLVTCSADKHVKIWD 412
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGK-YLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
374-412 5.96e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 5.96e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 41053569   374 KPVFTLRAHDGEVSGMDLSSQiRGCLVTCSADKHVKIWD 412
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPD-GKLLASGSDDGTVKVWD 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 375-469 7.92e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 44.63  E-value: 7.92e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053569 375 PVFTLRAHDGEVSGMDLSSQIRGcLVTCSADKHVKIWDILGNKP---NLIHSRdmkmGVLFCgSCCPDLPFVYAfGGQRE 451
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKL-LATGSGDGTIKVWDLETGELlrtLKGHTG----PVRDV-AASADGTYLAS-GSSDK 73

                        90
                ....*....|....*...
gi 41053569 452 GLRVWDISDVAAVAEVFG 469
Cdd:cd00200  74 TIRLWDLETGECVRTLTG 91
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 250-283 1.45e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 1.45e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 41053569    250 IEGHTDAVLDLSWNRLvRNVLASASADETVILWD 283
Cdd:smart00320   8 LKGHTGPVTSVAFSPD-GKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 286-326 1.75e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 1.75e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 41053569    286 KGKPAATLAKHTDKVQTLKFHPFEaQTLISGSFDKSVILYD 326
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDG-KYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 252-413 2.84e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 43.34  E-value: 2.84e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053569  252 GHTDAVLDLSWNRLVRNVLASASADETVILWDL-EKG------KPAATLAKHTDKVQTLKFHPFEAQTLISGSFDKSVIL 324
Cdd:PTZ00421  73 GQEGPIIDVAFNPFDPQKLFTASEDGTIMGWGIpEEGltqnisDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNV 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053569  325 YDCRSPDDSHRIWRFSGQVERVTWDhFSPCNFLASTEDGFIYCLDARSDKPVFTLRAHDGEVSGMDLSSQIRGCLVTCSA 404
Cdd:PTZ00421 153 WDVERGKAVEVIKCHSDQITSLEWN-LDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKSQRCLWAKRKDLIITLGC 231

                        170
                 ....*....|...
gi 41053569  405 DK----HVKIWDI 413
Cdd:PTZ00421 232 SKsqqrQIMLWDT 244
WD40 pfam00400
WD domain, G-beta repeat;
287-326 9.08e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 9.08e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 41053569   287 GKPAATLAKHTDKVQTLKFHPfEAQTLISGSFDKSVILYD 326
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
WD40 COG2319
WD40 repeat [General function prediction only];
202-285 1.69e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 40.66  E-value: 1.69e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053569 202 GNYAAVGNMTPVIDVWDLDVVDCLepafslgskkekkkkkkakkaaEPIEGHTDAVLDLSWNRlVRNVLASASADETVIL 281
Cdd:COG2319 342 GKTLASGSDDGTVRLWDLATGELL----------------------RTLTGHTGAVTSVAFSP-DGRTLASGSADGTVRL 398


                ....
gi 41053569 282 WDLE 285
Cdd:COG2319 399 WDLA 402
WD40 pfam00400
WD domain, G-beta repeat;
250-283 2.00e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.78  E-value: 2.00e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 41053569   250 IEGHTDAVLDLSWNRlVRNVLASASADETVILWD 283
Cdd:pfam00400   7 LEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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