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Conserved domains on  [gi|41053734|ref|NP_956555|]
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kelch domain-containing protein 10 [Danio rerio]

Protein Classification

Kelch repeat-containing protein( domain architecture ID 18656352)

Kelch repeat-containing protein, member of a superfamily of proteins with diverse functions; similar to Mus musculus Kelch domain-containing protein 4

CATH:  2.120.10.80
Gene Ontology:  GO:0005515
PubMed:  10603472|31442578|24959344
SCOP:  3000448

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
41-286 8.06e-27

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 107.93  E-value: 8.06e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053734  41 PARSGHRCVADNTNLYVFGGYNPDYDESGgsenedypLFRELWRFHFATGTWQQIRTegfMPTELASMSAVLHGNNLLVF 120
Cdd:COG3055  59 PPRHHAAAVAQDGKLYVFGGFTGANPSST--------PLNDVYVYDPATNTWTKLAP---MPTPRGGATALLLDGKIYVV 127

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053734 121 GGTGipfGENNGNDVHVCNVKYKRWSLLncrGKKPNRIYGQAMAII-SGFLYVFGGTTGYIYSTdlhrldlttrEWIHLK 199
Cdd:COG3055 128 GGWD---DGGNVAWVEVYDPATGTWTQL---APLPTPRDHLAAAVLpDGKILVIGGRNGSGFSN----------TWTTLA 191

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053734 200 PnnppddLPEERYRHEIAHDGQRIYILGGGTSWtsypLDKIHAYNLETNSWEEITTkpherigYPAPRRCHSCVQIKNDV 279
Cdd:COG3055 192 P------LPTARAGHAAAVLGGKILVFGGESGF----SDEVEAYDPATNTWTALGE-------LPTPRHGHAAVLTDGKV 254


                ....*..
gi 41053734 280 FICGGYN 286
Cdd:COG3055 255 YVIGGET 261
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 266-308 1.21e-08

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


:

Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 50.69  E-value: 1.21e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 41053734   266 PRRCHSCVQIKNDVFICGGYNGEVILDDLWKVNLQTFQWHKLP 308
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLP 43
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
41-286 8.06e-27

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 107.93  E-value: 8.06e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053734  41 PARSGHRCVADNTNLYVFGGYNPDYDESGgsenedypLFRELWRFHFATGTWQQIRTegfMPTELASMSAVLHGNNLLVF 120
Cdd:COG3055  59 PPRHHAAAVAQDGKLYVFGGFTGANPSST--------PLNDVYVYDPATNTWTKLAP---MPTPRGGATALLLDGKIYVV 127

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053734 121 GGTGipfGENNGNDVHVCNVKYKRWSLLncrGKKPNRIYGQAMAII-SGFLYVFGGTTGYIYSTdlhrldlttrEWIHLK 199
Cdd:COG3055 128 GGWD---DGGNVAWVEVYDPATGTWTQL---APLPTPRDHLAAAVLpDGKILVIGGRNGSGFSN----------TWTTLA 191

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053734 200 PnnppddLPEERYRHEIAHDGQRIYILGGGTSWtsypLDKIHAYNLETNSWEEITTkpherigYPAPRRCHSCVQIKNDV 279
Cdd:COG3055 192 P------LPTARAGHAAAVLGGKILVFGGESGF----SDEVEAYDPATNTWTALGE-------LPTPRHGHAAVLTDGKV 254


                ....*..
gi 41053734 280 FICGGYN 286
Cdd:COG3055 255 YVIGGET 261
PLN02193 PLN02193
nitrile-specifier protein
 36-255 7.29e-11

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 63.44  E-value: 7.29e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053734   36 GHRAPP--ARSGHRCVADNTNLYVFGGYNPDYDESGGSENEDYPLFRELwrfhfatGTWQQIRTEGFMPTELASMSAVLH 113
Cdd:PLN02193 102 GKTSHPieKRPGVKFVLQGGKIVGFHGRSTDVLHSLGAYISLPSTPKLL-------GKWIKVEQKGEGPGLRCSHGIAQV 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053734  114 GNNLLVFGGTGIPfgeNNGNDVH--VCNVKYKRWSLLNCRGKKPN-RIYGQAMAIISGFLYVFGGTTGYIYSTDLHRLDL 190
Cdd:PLN02193 175 GNKIYSFGGEFTP---NQPIDKHlyVFDLETRTWSISPATGDVPHlSCLGVRMVSIGSTLYVFGGRDASRQYNGFYSFDT 251

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 41053734  191 TTREWIHLkpnNPPDDLPEERYRHEIAHDGQRIYILGGGTSwtSYPLDKIHAYNLETNSWEEITT 255
Cdd:PLN02193 252 TTNEWKLL---TPVEEGPTPRSFHSMAADEENVYVFGGVSA--TARLKTLDSYNIVDKKWFHCST 311
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 266-308 1.21e-08

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 50.69  E-value: 1.21e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 41053734   266 PRRCHSCVQIKNDVFICGGYNGEVILDDLWKVNLQTFQWHKLP 308
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLP 43
Kelch_3 pfam13415
Galactose oxidase, central domain;
220-275 1.10e-06

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 44.97  E-value: 1.10e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 41053734   220 GQRIYILGGGTSWTSYPLDKIHAYNLETNSWEEITTKpherigyPAPRRCHSCVQI 275
Cdd:pfam13415   1 GDKLYIFGGLGFDGQTRLNDLYVYDLDTNTWTQIGDL-------PPPRSGHSATYI 49
Kelch smart00612
Kelch domain;
279-323 1.88e-04

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 38.69  E-value: 1.88e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 41053734    279 VFICGGYNGEVILDDLWKVNLQTFQWHKLPAvMPEPAYFHCAAVT 323
Cdd:smart00612   2 IYVVGGFDGGQRLKSVEVYDPETNKWTPLPS-MPTPRSGHGVAVI 45
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
41-286 8.06e-27

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 107.93  E-value: 8.06e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053734  41 PARSGHRCVADNTNLYVFGGYNPDYDESGgsenedypLFRELWRFHFATGTWQQIRTegfMPTELASMSAVLHGNNLLVF 120
Cdd:COG3055  59 PPRHHAAAVAQDGKLYVFGGFTGANPSST--------PLNDVYVYDPATNTWTKLAP---MPTPRGGATALLLDGKIYVV 127

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053734 121 GGTGipfGENNGNDVHVCNVKYKRWSLLncrGKKPNRIYGQAMAII-SGFLYVFGGTTGYIYSTdlhrldlttrEWIHLK 199
Cdd:COG3055 128 GGWD---DGGNVAWVEVYDPATGTWTQL---APLPTPRDHLAAAVLpDGKILVIGGRNGSGFSN----------TWTTLA 191

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053734 200 PnnppddLPEERYRHEIAHDGQRIYILGGGTSWtsypLDKIHAYNLETNSWEEITTkpherigYPAPRRCHSCVQIKNDV 279
Cdd:COG3055 192 P------LPTARAGHAAAVLGGKILVFGGESGF----SDEVEAYDPATNTWTALGE-------LPTPRHGHAAVLTDGKV 254


                ....*..
gi 41053734 280 FICGGYN 286
Cdd:COG3055 255 YVIGGET 261
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
90-352 1.77e-26

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 107.16  E-value: 1.77e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053734  90 GTWQQIrteGFMPTELASMSAVLHGNNLLVFGGTGipfGENNGNDVHVCNVKYKRWSLLncrGKKPNRIYGQAMA-IISG 168
Cdd:COG3055   1 ATWSSL---PDLPTPRSEAAAALLDGKVYVAGGLS---GGSASNSFEVYDPATNTWSEL---APLPGPPRHHAAAvAQDG 71

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053734 169 FLYVFGGTTG----YIYSTDLHRLDLTTREWIHLKPnnppddLPEERYRHEIAHDGQRIYILGGGTSwtSYPLDKIHAYN 244
Cdd:COG3055  72 KLYVFGGFTGanpsSTPLNDVYVYDPATNTWTKLAP------MPTPRGGATALLLDGKIYVVGGWDD--GGNVAWVEVYD 143

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053734 245 LETNSWEEITTKPHERIG-------------------------------YPAPRRCHSCVQIKNDVFICGGYNGevILDD 293
Cdd:COG3055 144 PATGTWTQLAPLPTPRDHlaaavlpdgkilviggrngsgfsntwttlapLPTARAGHAAAVLGGKILVFGGESG--FSDE 221

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 41053734 294 LWKVNLQTFQWHKLPAvMPEPAYFHcAAVTPAGCMYIHGGvvnihENKRTGSLFKIWLV 352
Cdd:COG3055 222 VEAYDPATNTWTALGE-LPTPRHGH-AAVLTDGKVYVIGG-----ETKPGVRTPLVTSA 273
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
40-231 4.45e-18

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 83.67  E-value: 4.45e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053734  40 PPARSGHRCVADNTNLYVFGGYNPDYDesggsenedyplFRELWRFHFATGTWQQIRTegfMPTELASMSAVLHGNN-LL 118
Cdd:COG3055 109 PTPRGGATALLLDGKIYVVGGWDDGGN------------VAWVEVYDPATGTWTQLAP---LPTPRDHLAAAVLPDGkIL 173

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053734 119 VFGGTGIPFGENNgndvhvcnvkykrWSLLncrGKKPNRIYGQAMAIISGFLYVFGGTTGyiYSTDLHRLDLTTREWIHL 198
Cdd:COG3055 174 VIGGRNGSGFSNT-------------WTTL---APLPTARAGHAAAVLGGKILVFGGESG--FSDEVEAYDPATNTWTAL 235

                       170       180       190
                ....*....|....*....|....*....|...
gi 41053734 199 kpnnppDDLPEERYRHEIAHDGQRIYILGGGTS 231
Cdd:COG3055 236 ------GELPTPRHGHAAVLTDGKVYVIGGETK 262
PLN02193 PLN02193
nitrile-specifier protein
 36-255 7.29e-11

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 63.44  E-value: 7.29e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053734   36 GHRAPP--ARSGHRCVADNTNLYVFGGYNPDYDESGGSENEDYPLFRELwrfhfatGTWQQIRTEGFMPTELASMSAVLH 113
Cdd:PLN02193 102 GKTSHPieKRPGVKFVLQGGKIVGFHGRSTDVLHSLGAYISLPSTPKLL-------GKWIKVEQKGEGPGLRCSHGIAQV 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053734  114 GNNLLVFGGTGIPfgeNNGNDVH--VCNVKYKRWSLLNCRGKKPN-RIYGQAMAIISGFLYVFGGTTGYIYSTDLHRLDL 190
Cdd:PLN02193 175 GNKIYSFGGEFTP---NQPIDKHlyVFDLETRTWSISPATGDVPHlSCLGVRMVSIGSTLYVFGGRDASRQYNGFYSFDT 251

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 41053734  191 TTREWIHLkpnNPPDDLPEERYRHEIAHDGQRIYILGGGTSwtSYPLDKIHAYNLETNSWEEITT 255
Cdd:PLN02193 252 TTNEWKLL---TPVEEGPTPRSFHSMAADEENVYVFGGVSA--TARLKTLDSYNIVDKKWFHCST 311
PLN02153 PLN02153
epithiospecifier protein
 90-253 3.98e-10

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 60.77  E-value: 3.98e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053734   90 GTWQQIRTEGFM-PTELASMSAVLHGNNLLVFGGTGIPfGENNGNDVHVCNVKYKRWSLLNCRGKKPN-RIYGQAMAIIS 167
Cdd:PLN02153   7 GGWIKVEQKGGKgPGPRCSHGIAVVGDKLYSFGGELKP-NEHIDKDLYVFDFNTHTWSIAPANGDVPRiSCLGVRMVAVG 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053734  168 GFLYVFGGTTGYIYSTDLHRLDLTTREWIHLKPNNPPDDlPEERYRHEIAHDGQRIYILG----GGTSWTSYPLDKIHAY 243
Cdd:PLN02153  86 TKLYIFGGRDEKREFSDFYSYDTVKNEWTFLTKLDEEGG-PEARTFHSMASDENHVYVFGgvskGGLMKTPERFRTIEAY 164

                        170
                 ....*....|
gi 41053734  244 NLETNSWEEI 253
Cdd:PLN02153 165 NIADGKWVQL 174
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 266-308 1.21e-08

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 50.69  E-value: 1.21e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 41053734   266 PRRCHSCVQIKNDVFICGGYNGEVILDDLWKVNLQTFQWHKLP 308
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLP 43
Kelch_4 pfam13418
Galactose oxidase, central domain;
266-312 1.17e-07

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 47.99  E-value: 1.17e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 41053734   266 PRRCHSCVQIKND-VFICGGYNGE-VILDDLWKVNLQTFQWHKLPAVMP 312
Cdd:pfam13418   1 PRAYHTSTSIPDDtIYLFGGEGEDgTLLSDLWVFDLSTNEWTRLGSLPS 49
PLN02153 PLN02153
epithiospecifier protein
 36-347 5.60e-07

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 51.14  E-value: 5.60e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053734   36 GHRAPPARSGHRCVADNTNLYVFGGynpdydESGGSENEDyplfRELWRFHFATGTWQQIRTEGFMPT-ELASMSAVLHG 114
Cdd:PLN02153  16 GGKGPGPRCSHGIAVVGDKLYSFGG------ELKPNEHID----KDLYVFDFNTHTWSIAPANGDVPRiSCLGVRMVAVG 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053734  115 NNLLVFGGTGipfGENNGNDVHVCNVKYKRWSL---LNCRGKKPNRIYgQAMAIISGFLYVFGGTT-GYIYST-----DL 185
Cdd:PLN02153  86 TKLYIFGGRD---EKREFSDFYSYDTVKNEWTFltkLDEEGGPEARTF-HSMASDENHVYVFGGVSkGGLMKTperfrTI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053734  186 HRLDLTTREWIHLkPNnpPDDLPEERYRHEIAHDGQRIY--------ILGGGTSwtSYPLDKIHAYNLETNSWEEITTKP 257
Cdd:PLN02153 162 EAYNIADGKWVQL-PD--PGENFEKRGGAGFAVVQGKIWvvygfatsILPGGKS--DYESNAVQFFDPASGKWTEVETTG 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053734  258 HErigyPAPRRCHSCVQIKNDVFICGG---------YNGEVILDDLWKVNLQTFQWHKL-----PAVMPEPAYFHCAAVT 323
Cdd:PLN02153 237 AK----PSARSVFAHAVVGKYIIIFGGevwpdlkghLGPGTLSNEGYALDTETLVWEKLgecgePAMPRGWTAYTTATVY 312

                        330       340
                 ....*....|....*....|....
gi 41053734  324 PAGCMYIHGGvvNIHENKRTGSLF 347
Cdd:PLN02153 313 GKNGLLMHGG--KLPTNERTDDLY 334
Kelch_3 pfam13415
Galactose oxidase, central domain;
220-275 1.10e-06

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 44.97  E-value: 1.10e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 41053734   220 GQRIYILGGGTSWTSYPLDKIHAYNLETNSWEEITTKpherigyPAPRRCHSCVQI 275
Cdd:pfam13415   1 GDKLYIFGGLGFDGQTRLNDLYVYDLDTNTWTQIGDL-------PPPRSGHSATYI 49
PLN02193 PLN02193
nitrile-specifier protein
 144-333 1.26e-06

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 50.34  E-value: 1.26e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053734  144 RWSLLNCRGKKPNRIYGQAMAIISGFLYVFGG--TTGYIYSTDLHRLDLTTREWiHLKPNNppDDLPE-ERYRHEIAHDG 220
Cdd:PLN02193 152 KWIKVEQKGEGPGLRCSHGIAQVGNKIYSFGGefTPNQPIDKHLYVFDLETRTW-SISPAT--GDVPHlSCLGVRMVSIG 228

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053734  221 QRIYILGGGTSWTSYplDKIHAYNLETNSWEEITtkPHERigYPAPRRCHSCVQIKNDVFICGGYNGEVILDDLWKVNLQ 300
Cdd:PLN02193 229 STLYVFGGRDASRQY--NGFYSFDTTTNEWKLLT--PVEE--GPTPRSFHSMAADEENVYVFGGVSATARLKTLDSYNIV 302

                        170       180       190
                 ....*....|....*....|....*....|...
gi 41053734  301 TFQWhklpavmpepayFHCAavTPAGCMYIHGG 333
Cdd:PLN02193 303 DKKW------------FHCS--TPGDSFSIRGG 321
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 211-257 3.65e-06

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 43.37  E-value: 3.65e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 41053734   211 RYRHEIAHDGQRIYILGGGTSWTsyPLDKIHAYNLETNSWEEITTKP 257
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGNQ--SLNSVEVYDPETNTWSKLPSMP 46
PHA03098 PHA03098
kelch-like protein; Provisional
 159-304 3.74e-06

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 49.00  E-value: 3.74e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053734  159 YGQAMAIISGFLYVFGGTTGYIYSTD-LHRLDLTTREWIHLKPnnppddLPEERYRHEIAHDGQRIYILgGGTSWTSYP- 236
Cdd:PHA03098 381 YNPCVVNVNNLIYVIGGISKNDELLKtVECFSLNTNKWSKGSP------LPISHYGGCAIYHDGKIYVI-GGISYIDNIk 453

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 41053734  237 -LDKIHAYNLETNSWEEITTKPHERIGypaprrcHSCVQIKNDVFICGGYNGEVILDDLWKVNLQTFQW 304
Cdd:PHA03098 454 vYNIVESYNPVTNKWTELSSLNFPRIN-------ASLCIFNNKIYVVGGDKYEYYINEIEVYDDKTNTW 515
Kelch_6 pfam13964
Kelch motif;
211-260 5.18e-06

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 43.09  E-value: 5.18e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 41053734   211 RYRHEIAHDGQRIYILGGGTSWTSYpLDKIHAYNLETNSWEEITTKPHER 260
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGYTNASPA-LNKLEVYNPLTKSWEELPPLPTPR 50
PHA03098 PHA03098
kelch-like protein; Provisional
 42-251 7.81e-06

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 47.84  E-value: 7.81e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053734   42 ARSGHRCVADNTNLYVFGGYnpdydesggsENEDYPLFRELWRFhfatgTWQQIRTEGFMPTELASMSAVLHGNNLLVFG 121
Cdd:PHA03098 332 PRKNPGVTVFNNRIYVIGGI----------YNSISLNTVESWKP-----GESKWREEPPLIFPRYNPCVVNVNNLIYVIG 396

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053734  122 GtgIPFGENNGNDVHVCNVKYKRWSLLNCrgkKPNRIYGQAMAIISGFLYVFGGTTgyiYSTDLHRL------DLTTREW 195
Cdd:PHA03098 397 G--ISKNDELLKTVECFSLNTNKWSKGSP---LPISHYGGCAIYHDGKIYVIGGIS---YIDNIKVYnivesyNPVTNKW 468

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 41053734  196 IHLKPNNPPddlpeeRYRHEIAHDGQRIYILGGGTSwtSYPLDKIHAYNLETNSWE 251
Cdd:PHA03098 469 TELSSLNFP------RINASLCIFNNKIYVVGGDKY--EYYINEIEVYDDKTNTWT 516
PHA03098 PHA03098
kelch-like protein; Provisional
 73-308 2.08e-05

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 46.30  E-value: 2.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053734   73 NEDYPLFRELWRFHFAT----GTWQQIRTEGFMPTELASMS---------AVLHGNNLLVFGGTgipfgENNG---NDVH 136
Cdd:PHA03098 240 NKILPRSSTFGSIIYIHitmsIFTYNYITNYSPLSEINTIIdihyvycfgSVVLNNVIYFIGGM-----NKNNlsvNSVV 314

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053734  137 VCNVKYKRWsllncrGKKPNRIY---GQAMAIISGFLYVFGGTTGYIYSTDLHRLDLTTREWIHLKPNNPPddlpeeRYR 213
Cdd:PHA03098 315 SYDTKTKSW------NKVPELIYprkNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPLIFP------RYN 382

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053734  214 HEIAHDGQRIYILgGGTSWTSYPLDKIHAYNLETNSWEEITTKPHERIGypaprrcHSCVQIKNDVFICGGY---NGEVI 290
Cdd:PHA03098 383 PCVVNVNNLIYVI-GGISKNDELLKTVECFSLNTNKWSKGSPLPISHYG-------GCAIYHDGKIYVIGGIsyiDNIKV 454

                        250
                 ....*....|....*...
gi 41053734  291 LDDLWKVNLQTFQWHKLP 308
Cdd:PHA03098 455 YNIVESYNPVTNKWTELS 472
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 208-248 3.53e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 40.63  E-value: 3.53e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 41053734   208 PEERYRHEIAHDGQRIYILGGGTSWTSYPLDKIHAYNLETN 248
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGYTGGEGQPSDDVYVLSLPTF 41
Kelch_4 pfam13418
Galactose oxidase, central domain;
42-95 4.97e-05

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 40.29  E-value: 4.97e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 41053734    42 ARSGHRCVA-DNTNLYVFGGYNpdydesggsenEDYPLFRELWRFHFATGTWQQI 95
Cdd:pfam13418   1 PRAYHTSTSiPDDTIYLFGGEG-----------EDGTLLSDLWVFDLSTNEWTRL 44
PRK14131 PRK14131
N-acetylneuraminate epimerase;
41-122 5.02e-05

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 45.01  E-value: 5.02e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053734   41 PARSGHRCVADNTNLYVFGGynpdydeSGGSENEDYP-LFRELWRFHFATGTWQQIRTEGfmPTELA-SMSAVLHGNNLL 118
Cdd:PRK14131  73 GPREQAVAAFIDGKLYVFGG-------IGKTNSEGSPqVFDDVYKYDPKTNSWQKLDTRS--PVGLAgHVAVSLHNGKAY 143


                 ....
gi 41053734  119 VFGG 122
Cdd:PRK14131 144 ITGG 147
PHA03098 PHA03098
kelch-like protein; Provisional
 223-343 6.73e-05

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 44.76  E-value: 6.73e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053734  223 IYILGGGTSwTSYPLDKIHAYNLETNSWEEITTKPHerigypaPRRCHSCVQIKNDVFICGGYNGEVILDDLWKVNLQTF 302
Cdd:PHA03098 297 IYFIGGMNK-NNLSVNSVVSYDTKTKSWNKVPELIY-------PRKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGES 368

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 41053734  303 QWHKLPAvMPEPAYFHCAAVTpAGCMYIHGGVVNIHENKRT 343
Cdd:PHA03098 369 KWREEPP-LIFPRYNPCVVNV-NNLIYVIGGISKNDELLKT 407
Kelch smart00612
Kelch domain;
279-323 1.88e-04

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 38.69  E-value: 1.88e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 41053734    279 VFICGGYNGEVILDDLWKVNLQTFQWHKLPAvMPEPAYFHCAAVT 323
Cdd:smart00612   2 IYVVGGFDGGQRLKSVEVYDPETNKWTPLPS-MPTPRSGHGVAVI 45
Kelch_4 pfam13418
Galactose oxidase, central domain;
216-258 2.01e-04

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 38.75  E-value: 2.01e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 41053734   216 IAHDGQRIYILGGgTSWTSYPLDKIHAYNLETNSWEEITTKPH 258
Cdd:pfam13418   8 TSIPDDTIYLFGG-EGEDGTLLSDLWVFDLSTNEWTRLGSLPS 49
Kelch_4 pfam13418
Galactose oxidase, central domain;
157-195 2.38e-04

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 38.36  E-value: 2.38e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 41053734   157 RIYGQAMAIISGFLYVFGGTT--GYIYStDLHRLDLTTREW 195
Cdd:pfam13418   2 RAYHTSTSIPDDTIYLFGGEGedGTLLS-DLWVFDLSTNEW 41
PRK14131 PRK14131
N-acetylneuraminate epimerase;
217-334 2.86e-04

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 42.69  E-value: 2.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053734  217 AHDGQRIYI-LG-GGTSWtsYPLDkihaYNLETNSWEEITTKPHerigypAPRRCHSCVQIKNDVFICGGY-----NGEV 289
Cdd:PRK14131  35 AIDNNTVYVgLGsAGTSW--YKLD----LNAPSKGWTKIAAFPG------GPREQAVAAFIDGKLYVFGGIgktnsEGSP 102

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 41053734  290 IL-DDLWKVNLQTFQWHKLPAVMPEPAYFHcAAVTPAGCM-YIHGGV 334
Cdd:PRK14131 103 QVfDDVYKYDPKTNSWQKLDTRSPVGLAGH-VAVSLHNGKaYITGGV 148
Kelch_6 pfam13964
Kelch motif;
266-314 3.55e-04

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 38.09  E-value: 3.55e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 41053734   266 PRRCHSCVQIKNDVFICGGY-NGEVILDDLWKVNLQTFQWHKLPAvMPEP 314
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYtNASPALNKLEVYNPLTKSWEELPP-LPTP 49
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 40-68 8.96e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 36.77  E-value: 8.96e-04
                          10        20
                  ....*....|....*....|....*....
gi 41053734    40 PPARSGHRCVADNTNLYVFGGYNPDYDES 68
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGYTGGEGQP 29
PRK14131 PRK14131
N-acetylneuraminate epimerase;
21-122 3.06e-03

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 39.23  E-value: 3.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053734   21 NQFERLSGRPPLRAAGHRApparsghrCVADNTNLYVFGGYN--------PDYDESGGSEN--------------EDYPL 78
Cdd:PRK14131 116 NSWQKLDTRSPVGLAGHVA--------VSLHNGKAYITGGVNknifdgyfEDLAAAGKDKTpkdkindayfdkkpEDYFF 187

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 41053734   79 FRELWRFHFATGTWQQIRTEGFMPTelASMSAVLHGNNLLVFGG 122
Cdd:PRK14131 188 NKEVLSYDPSTNQWKNAGESPFLGT--AGSAVVIKGNKLWLING 229
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 42-97 3.43e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 35.28  E-value: 3.43e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 41053734    42 ARSGHRCVADNTNLYVFGGYNPDydesggsenedyPLFRELWRFHFATGTWQQIRT 97
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGN------------QSLNSVEVYDPETNTWSKLPS 44
Kelch_6 pfam13964
Kelch motif;
160-198 4.60e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 35.00  E-value: 4.60e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 41053734   160 GQAMAIISGFLYVFGGTTGY-IYSTDLHRLDLTTREWIHL 198
Cdd:pfam13964   4 FHSVVSVGGYIYVFGGYTNAsPALNKLEVYNPLTKSWEEL 43
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 159-202 5.66e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 34.51  E-value: 5.66e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 41053734   159 YGQAMAIISGFLYVFGGTTGYIYSTDLHRLDLTTREWIHLKPNN 202
Cdd:pfam01344   3 SGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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