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Conserved domains on  [gi|80861398|ref|NP_942045|]
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cryptochrome-1 [Rattus norvegicus]

Protein Classification

cryptochrome/photolyase family protein( domain architecture ID 11417839)

cryptochrome/photolyase family protein may act as a DNA photolyase such as deoxyribodipyrimidine photo-lyase, which is involved in repair of UV radiation-induced DNA damage by catalyzing the light-dependent monomerization of cyclobutyl pyrimidine dimers. Photolyases and cryptochromes are related flavoproteins; while photolyases harness the energy of blue light to repair DNA damage by removing pyrimidine dimers, cryptochromes do not repair DNA and are presumed to act instead in some other (possibly unknown) process such as entraining circadian rhythms. They may show weak photolyase activity in vitro but have not been shown to affect DNA repair in vivo. Rather, DASH family cryptochromes have been shown to bind RNA or DNA, and seem likely to act in light-responsive regulatory processes.

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PhrB COG0415
Deoxyribodipyrimidine photolyase [Replication, recombination and repair];
5-487 2.94e-132

Deoxyribodipyrimidine photolyase [Replication, recombination and repair];


:

Pssm-ID: 440184 [Multi-domain]  Cd Length: 466  Bit Score: 394.49  E-value: 2.94e-132
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 80861398   5 AVHWFRKGLRLHDNPALKECIQGADTIRCVYILDPWFAGSSNVGINRWRFLLQCLEDLDANLRKLNSRLFVIRGQPADVF 84
Cdd:COG0415   4 ALVWFRRDLRLHDNPALAAAAESGDPVIPVFILDPEQLGPHPLGAARRWFLHESLAALDASLRELGSRLIVRRGDPEEVL 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 80861398  85 PRLFKEWNITKLSIEYDSEPFGKERDAAIKKLATEAGVEVIVRISHTLYDLDKIieLNG-GQPPLTY----KRFQTLVsK 159
Cdd:COG0415  84 PALARELGADAVYWNRDYEPYERARDAAVKAALREAGIEVHSFNDHLLFEPGEV--LTGsGTPYKVFtpfwKAWLKRL-K 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 80861398 160 MEPLEMPadtitsDVIGKCTTPLSDDhdekygvpSLEELGFDTDGLSSAVWPGGETEALTRLERHLERKawVANFERPR- 238
Cdd:COG0415 161 RAPLPAP------SALPALPIPPESD--------TLADLGLLPTDGLALLWPPGEAAALERLEDFLDDR--LADYDETRd 224
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 80861398 239 ---MNANSllasptGLSPYLRFGCLSCRLFYFKLTDLYKKVKKNSspPLSLYGQLLWREFFYTAATNNPRFDKMEGNPIC 315
Cdd:COG0415 225 fpaLDGTS------RLSPHLAFGEISPRQVWHAALAALEEEGGEG--AETFLSELAWREFYYHLLYHFPDLATENFRPEF 296
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 80861398 316 VQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRgDLWISWEEGMKVFEELLLDADWSINAG 395
Cdd:COG0415 297 DAIPWRNDEELFEAWQEGRTGYPIVDAGMRQLNQTGWMHNRVRMIVASFLTK-DLLIDWRWGERWFMDTLVDGDLASNNG 375
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 80861398 396 SWMWLScSS------FFQQFfhcyCPVGFGRRTDPNGDYIRRYLPVLRGFPAKYIYDPWNAPEGIQKVAkclIGVNYPKP 469
Cdd:COG0415 376 GWQWAA-GTgtdaapYFRIF----NPVTQGEKFDPDGDYIRRWVPELADLPAKYIHEPWKAPPLELKAR---LGKDYPAP 447
                       490
                ....*....|....*...
gi 80861398 470 MVNHAEASRLNIERMKQI 487
Cdd:COG0415 448 IVDHKEARERALAAYKAA 465
 
Name Accession Description Interval E-value
PhrB COG0415
Deoxyribodipyrimidine photolyase [Replication, recombination and repair];
5-487 2.94e-132

Deoxyribodipyrimidine photolyase [Replication, recombination and repair];


Pssm-ID: 440184 [Multi-domain]  Cd Length: 466  Bit Score: 394.49  E-value: 2.94e-132
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 80861398   5 AVHWFRKGLRLHDNPALKECIQGADTIRCVYILDPWFAGSSNVGINRWRFLLQCLEDLDANLRKLNSRLFVIRGQPADVF 84
Cdd:COG0415   4 ALVWFRRDLRLHDNPALAAAAESGDPVIPVFILDPEQLGPHPLGAARRWFLHESLAALDASLRELGSRLIVRRGDPEEVL 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 80861398  85 PRLFKEWNITKLSIEYDSEPFGKERDAAIKKLATEAGVEVIVRISHTLYDLDKIieLNG-GQPPLTY----KRFQTLVsK 159
Cdd:COG0415  84 PALARELGADAVYWNRDYEPYERARDAAVKAALREAGIEVHSFNDHLLFEPGEV--LTGsGTPYKVFtpfwKAWLKRL-K 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 80861398 160 MEPLEMPadtitsDVIGKCTTPLSDDhdekygvpSLEELGFDTDGLSSAVWPGGETEALTRLERHLERKawVANFERPR- 238
Cdd:COG0415 161 RAPLPAP------SALPALPIPPESD--------TLADLGLLPTDGLALLWPPGEAAALERLEDFLDDR--LADYDETRd 224
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 80861398 239 ---MNANSllasptGLSPYLRFGCLSCRLFYFKLTDLYKKVKKNSspPLSLYGQLLWREFFYTAATNNPRFDKMEGNPIC 315
Cdd:COG0415 225 fpaLDGTS------RLSPHLAFGEISPRQVWHAALAALEEEGGEG--AETFLSELAWREFYYHLLYHFPDLATENFRPEF 296
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 80861398 316 VQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRgDLWISWEEGMKVFEELLLDADWSINAG 395
Cdd:COG0415 297 DAIPWRNDEELFEAWQEGRTGYPIVDAGMRQLNQTGWMHNRVRMIVASFLTK-DLLIDWRWGERWFMDTLVDGDLASNNG 375
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 80861398 396 SWMWLScSS------FFQQFfhcyCPVGFGRRTDPNGDYIRRYLPVLRGFPAKYIYDPWNAPEGIQKVAkclIGVNYPKP 469
Cdd:COG0415 376 GWQWAA-GTgtdaapYFRIF----NPVTQGEKFDPDGDYIRRWVPELADLPAKYIHEPWKAPPLELKAR---LGKDYPAP 447
                       490
                ....*....|....*...
gi 80861398 470 MVNHAEASRLNIERMKQI 487
Cdd:COG0415 448 IVDHKEARERALAAYKAA 465
FAD_binding_7 pfam03441
FAD binding domain of DNA photolyase;
288-486 2.59e-109

FAD binding domain of DNA photolyase;


Pssm-ID: 460917 [Multi-domain]  Cd Length: 201  Bit Score: 325.57  E-value: 2.59e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 80861398   288 GQLLWREFFYTAATNNPRF-DKMEGNPICvQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLT 366
Cdd:pfam03441   3 SELAWREFYYQLLEHFPELeDRNLRPAFD-RIPWREDEELFEAWKEGRTGYPIVDAAMRQLRQTGWMHNRVRMIVASFLT 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 80861398   367 RgDLWISWEEGMKVFEELLLDADWSINAGSWMWLSCSSFFQQ-FFHCYCPVGFGRRTDPNGDYIRRYLPVLRGFPAKYIY 445
Cdd:pfam03441  82 K-DLLIDWREGARWFAETLVDADPASNNGGWQWVAGTGTDAApYFRIFNPVTQGEKFDPDGEYIRRWVPELADLPAKYIH 160
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 80861398   446 DPWNAPEGIQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQ 486
Cdd:pfam03441 161 EPWKAPAPVQRLAGCVLGKDYPAPIVDHKEARKRALARYKA 201
crypto_DASH TIGR02765
cryptochrome, DASH family; Photolyases and cryptochromes are related flavoproteins. ...
6-436 1.57e-59

cryptochrome, DASH family; Photolyases and cryptochromes are related flavoproteins. Photolyases harness the energy of blue light to repair DNA damage by removing pyrimidine dimers. Cryptochromes do not repair DNA and are presumed to act instead in some other (possibly unknown) process such as entraining circadian rhythms. This model describes the cryptochrome DASH subfamily, one of at least five major subfamilies, which is found in plants, animals, marine bacteria, etc. Members of this family bind both folate and FAD. They may show weak photolyase activity in vitro but have not been shown to affect DNA repair in vivo. Rather, DASH family cryptochromes have been shown to bind RNA (Vibrio cholerae VC1814), or DNA, and seem likely to act in light-responsive regulatory processes. [Cellular processes, Adaptations to atypical conditions]


Pssm-ID: 274288 [Multi-domain]  Cd Length: 429  Bit Score: 204.14  E-value: 1.57e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 80861398     6 VHWFRKGLRLHDNPALKECIQGADTIRCVYILDP------WFAGSSNVGINRWRFLLQCLEDLDANLRKLNSRLFVIRGQ 79
Cdd:TIGR02765   4 LYWFRNDLRVHDNPALYKASSSSDTLIPLYCFDPrqfkltHFFGFPKTGPARGKFLLESLKDLRTSLRKLGSDLLVRSGK 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 80861398    80 PADVFPRLFKEWNITklSIEYDSEPFGKER--DAAIKKLATEAGVEVIVRISHTLYDLDKI-IELNGgqPPLTYKRFQtl 156
Cdd:TIGR02765  84 PEDVLPELIKELGVR--TVFLHQEVGSEEKsvERLLQQALARLGIHVEQHWGSTLYHEDDLpFDLED--LPDVFTQFR-- 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 80861398   157 vSKMEPLEMPADTI-TSDVIGkcTTPLSDDHDEkygVPSLEELGFD-TDGLSSAVWPGGETEALTRLERHLerkaWVANF 234
Cdd:TIGR02765 158 -KQVEAKCSIRPPLpAPEKLP--PLPSVDDPGW---IPTLEDLGEEsSEVDRGLPFVGGETAGLARLKEYF----WSKDL 227
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 80861398   235 ERPRMNANSLL--ASPTGLSPYLRFGCLSCRLFYFKLTDLYKKVKKNSSpPLSLYGQLLWREFFY-TAATNNPRFDKMEG 311
Cdd:TIGR02765 228 KSYKETRNGMLgpDYSTKFSPWLALGCVSPRQIYEELQRYETERGANDS-TYWVIFELLWRDYFRfYALKYGNRLFRFGG 306
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 80861398   312 nPICVQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRgDLWISWEEGMKVFEELLLDADWS 391
Cdd:TIGR02765 307 -LRGKHPKWSFDAKRFEQWKTGTTGYPLVDANMRELNATGFMSNRGRQNVASFLVK-DLGLDWRYGAEWFETQLVDYDVC 384
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 80861398   392 INAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIRRYLPVL 436
Cdd:TIGR02765 385 SNWGNWQYLAGVGNDPRGSRQFNIEKQAQDYDPDGEYVATWVPEL 429
PRK10674 PRK10674
deoxyribodipyrimidine photolyase; Provisional
8-476 6.71e-42

deoxyribodipyrimidine photolyase; Provisional


Pssm-ID: 236734 [Multi-domain]  Cd Length: 472  Bit Score: 157.49  E-value: 6.71e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 80861398    8 WFRKGLRLHDNPALKECIQGAD-TIRCVYILDPwfagssnvgiNRWR----------FLLQCLEDLDANLRKLNSRLFVI 76
Cdd:PRK10674   7 WFRNDLRLHDNLALAAACRDPSaRVLALFIATP----------AQWAahdmaprqaaFINAQLNALQIALAEKGIPLLFH 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 80861398   77 rgQPADvfprlFK---EW--------NITKLSIEYDSEPFGKERDAAIKKLATEagveVIVRISHtlydlDKIIelnggQ 145
Cdd:PRK10674  77 --EVDD-----FAasvEWlkqfcqqhQVTHLFYNYQYEVNERQRDAAVERALRN----VVCQGFD-----DSVL-----L 135
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 80861398  146 PP---LT-----YKRF--------QTLVSKMePLEMPADTITSDviGKCTTPlsddhdekygvpSLEELGFDTDGLSSAV 209
Cdd:PRK10674 136 PPgsvMTgnhemYKVFtpfknaflKRLREGD-PECVPAPKVRSS--GAIEPL------------PPIPFNYPQQSFDTAL 200
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 80861398  210 WPGGETEALTRLeRHLERKAwVANFERPRmnanSLLASP--TGLSPYLRFGCLSCRLFYFKLTDLYKKVKKNSSPPLSLy 287
Cdd:PRK10674 201 FPVGEKAAIAQL-RQFCQQG-AGEYEQQR----DFPAVDgtSRLSAYLATGVLSPRQCLHRLLAEQPQALDGGAGSVWL- 273
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 80861398  288 GQLLWREFFYTAATNNPRfdkmegnpICVQIP---------WDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLAR 358
Cdd:PRK10674 274 NELIWREFYRHLMVAYPS--------LCKHRPfiawtdrvqWQSNPAHLQAWQQGKTGYPIVDAAMRQLNSTGWMHNRLR 345
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 80861398  359 HAVACFLTRgDLWISWEEGMKVFEELLLDADWSINAGSWMW-LSCSSFFQQFFHCYCPVGFGRRTDPNGDYIRRYLPVLR 437
Cdd:PRK10674 346 MITASFLVK-DLLIDWREGERYFMSQLIDGDLAANNGGWQWaASTGTDAAPYFRIFNPTTQGERFDRDGEFIRRWLPELR 424
                        490       500       510
                 ....*....|....*....|....*....|....*....
gi 80861398  438 GFPAKYIYDPWNAPEGIQKVakcligVNYPKPMVNHAEA 476
Cdd:PRK10674 425 DVPGKAIHQPWRWAEKAGVT------LDYPQPIVDHKQA 457
 
Name Accession Description Interval E-value
PhrB COG0415
Deoxyribodipyrimidine photolyase [Replication, recombination and repair];
5-487 2.94e-132

Deoxyribodipyrimidine photolyase [Replication, recombination and repair];


Pssm-ID: 440184 [Multi-domain]  Cd Length: 466  Bit Score: 394.49  E-value: 2.94e-132
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 80861398   5 AVHWFRKGLRLHDNPALKECIQGADTIRCVYILDPWFAGSSNVGINRWRFLLQCLEDLDANLRKLNSRLFVIRGQPADVF 84
Cdd:COG0415   4 ALVWFRRDLRLHDNPALAAAAESGDPVIPVFILDPEQLGPHPLGAARRWFLHESLAALDASLRELGSRLIVRRGDPEEVL 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 80861398  85 PRLFKEWNITKLSIEYDSEPFGKERDAAIKKLATEAGVEVIVRISHTLYDLDKIieLNG-GQPPLTY----KRFQTLVsK 159
Cdd:COG0415  84 PALARELGADAVYWNRDYEPYERARDAAVKAALREAGIEVHSFNDHLLFEPGEV--LTGsGTPYKVFtpfwKAWLKRL-K 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 80861398 160 MEPLEMPadtitsDVIGKCTTPLSDDhdekygvpSLEELGFDTDGLSSAVWPGGETEALTRLERHLERKawVANFERPR- 238
Cdd:COG0415 161 RAPLPAP------SALPALPIPPESD--------TLADLGLLPTDGLALLWPPGEAAALERLEDFLDDR--LADYDETRd 224
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 80861398 239 ---MNANSllasptGLSPYLRFGCLSCRLFYFKLTDLYKKVKKNSspPLSLYGQLLWREFFYTAATNNPRFDKMEGNPIC 315
Cdd:COG0415 225 fpaLDGTS------RLSPHLAFGEISPRQVWHAALAALEEEGGEG--AETFLSELAWREFYYHLLYHFPDLATENFRPEF 296
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 80861398 316 VQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRgDLWISWEEGMKVFEELLLDADWSINAG 395
Cdd:COG0415 297 DAIPWRNDEELFEAWQEGRTGYPIVDAGMRQLNQTGWMHNRVRMIVASFLTK-DLLIDWRWGERWFMDTLVDGDLASNNG 375
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 80861398 396 SWMWLScSS------FFQQFfhcyCPVGFGRRTDPNGDYIRRYLPVLRGFPAKYIYDPWNAPEGIQKVAkclIGVNYPKP 469
Cdd:COG0415 376 GWQWAA-GTgtdaapYFRIF----NPVTQGEKFDPDGDYIRRWVPELADLPAKYIHEPWKAPPLELKAR---LGKDYPAP 447
                       490
                ....*....|....*...
gi 80861398 470 MVNHAEASRLNIERMKQI 487
Cdd:COG0415 448 IVDHKEARERALAAYKAA 465
FAD_binding_7 pfam03441
FAD binding domain of DNA photolyase;
288-486 2.59e-109

FAD binding domain of DNA photolyase;


Pssm-ID: 460917 [Multi-domain]  Cd Length: 201  Bit Score: 325.57  E-value: 2.59e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 80861398   288 GQLLWREFFYTAATNNPRF-DKMEGNPICvQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLT 366
Cdd:pfam03441   3 SELAWREFYYQLLEHFPELeDRNLRPAFD-RIPWREDEELFEAWKEGRTGYPIVDAAMRQLRQTGWMHNRVRMIVASFLT 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 80861398   367 RgDLWISWEEGMKVFEELLLDADWSINAGSWMWLSCSSFFQQ-FFHCYCPVGFGRRTDPNGDYIRRYLPVLRGFPAKYIY 445
Cdd:pfam03441  82 K-DLLIDWREGARWFAETLVDADPASNNGGWQWVAGTGTDAApYFRIFNPVTQGEKFDPDGEYIRRWVPELADLPAKYIH 160
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 80861398   446 DPWNAPEGIQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQ 486
Cdd:pfam03441 161 EPWKAPAPVQRLAGCVLGKDYPAPIVDHKEARKRALARYKA 201
crypto_DASH TIGR02765
cryptochrome, DASH family; Photolyases and cryptochromes are related flavoproteins. ...
6-436 1.57e-59

cryptochrome, DASH family; Photolyases and cryptochromes are related flavoproteins. Photolyases harness the energy of blue light to repair DNA damage by removing pyrimidine dimers. Cryptochromes do not repair DNA and are presumed to act instead in some other (possibly unknown) process such as entraining circadian rhythms. This model describes the cryptochrome DASH subfamily, one of at least five major subfamilies, which is found in plants, animals, marine bacteria, etc. Members of this family bind both folate and FAD. They may show weak photolyase activity in vitro but have not been shown to affect DNA repair in vivo. Rather, DASH family cryptochromes have been shown to bind RNA (Vibrio cholerae VC1814), or DNA, and seem likely to act in light-responsive regulatory processes. [Cellular processes, Adaptations to atypical conditions]


Pssm-ID: 274288 [Multi-domain]  Cd Length: 429  Bit Score: 204.14  E-value: 1.57e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 80861398     6 VHWFRKGLRLHDNPALKECIQGADTIRCVYILDP------WFAGSSNVGINRWRFLLQCLEDLDANLRKLNSRLFVIRGQ 79
Cdd:TIGR02765   4 LYWFRNDLRVHDNPALYKASSSSDTLIPLYCFDPrqfkltHFFGFPKTGPARGKFLLESLKDLRTSLRKLGSDLLVRSGK 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 80861398    80 PADVFPRLFKEWNITklSIEYDSEPFGKER--DAAIKKLATEAGVEVIVRISHTLYDLDKI-IELNGgqPPLTYKRFQtl 156
Cdd:TIGR02765  84 PEDVLPELIKELGVR--TVFLHQEVGSEEKsvERLLQQALARLGIHVEQHWGSTLYHEDDLpFDLED--LPDVFTQFR-- 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 80861398   157 vSKMEPLEMPADTI-TSDVIGkcTTPLSDDHDEkygVPSLEELGFD-TDGLSSAVWPGGETEALTRLERHLerkaWVANF 234
Cdd:TIGR02765 158 -KQVEAKCSIRPPLpAPEKLP--PLPSVDDPGW---IPTLEDLGEEsSEVDRGLPFVGGETAGLARLKEYF----WSKDL 227
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 80861398   235 ERPRMNANSLL--ASPTGLSPYLRFGCLSCRLFYFKLTDLYKKVKKNSSpPLSLYGQLLWREFFY-TAATNNPRFDKMEG 311
Cdd:TIGR02765 228 KSYKETRNGMLgpDYSTKFSPWLALGCVSPRQIYEELQRYETERGANDS-TYWVIFELLWRDYFRfYALKYGNRLFRFGG 306
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 80861398   312 nPICVQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRgDLWISWEEGMKVFEELLLDADWS 391
Cdd:TIGR02765 307 -LRGKHPKWSFDAKRFEQWKTGTTGYPLVDANMRELNATGFMSNRGRQNVASFLVK-DLGLDWRYGAEWFETQLVDYDVC 384
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 80861398   392 INAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIRRYLPVL 436
Cdd:TIGR02765 385 SNWGNWQYLAGVGNDPRGSRQFNIEKQAQDYDPDGEYVATWVPEL 429
DNA_photolyase pfam00875
DNA photolyase; This domain binds a light harvesting cofactor.
5-167 3.39e-54

DNA photolyase; This domain binds a light harvesting cofactor.


Pssm-ID: 459974 [Multi-domain]  Cd Length: 161  Bit Score: 181.25  E-value: 3.39e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 80861398     5 AVHWFRKGLRLHDNPALKECIQGADTIRCVYILDPWFAgssNVGINRWRFLLQCLEDLDANLRKLNSRLFVIRGQPADVF 84
Cdd:pfam00875   1 VLVWFRRDLRLHDNPALAAAAASGAPLIPVFILDPAFH---DLGAARRWFLLESLADLDEELRERGIRLVVRRGDPADVL 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 80861398    85 PRLFKEWNITKLSIEYDSEPFGKERDAAIKKLATEAGVEVIVRISHTLYDLDkIIELNGGQPPLTYKRFQTLVSK--MEP 162
Cdd:pfam00875  78 PELAKELGASAVFANRDYEPYERRRDAAVAEALREAGVEVHSFDGHTLVPPG-EVRTKKGKPYRVFTPFWKAWLAelLEP 156

                  ....*
gi 80861398   163 LEMPA 167
Cdd:pfam00875 157 LPAPA 161
crypt_chrom_pln TIGR02766
cryptochrome, plant family; At least five major families of cryptochomes and photolyases share ...
6-476 8.99e-43

cryptochrome, plant family; At least five major families of cryptochomes and photolyases share FAD cofactor binding, sequence homology, and the ability to react to short wavelengths of visible light. Photolysases are responsible for light-dependent DNA repair by removal of two types of uv-induced DNA dimerizations. Cryptochromes have other functions, often regulatory and often largely unknown, which may include circadian clock entrainment and control of development. Members of this subfamily are known so far only in plants; they may show some photolyase activity in vitro but appear mostly to be regulatory proteins that respond to blue light.


Pssm-ID: 131813 [Multi-domain]  Cd Length: 475  Bit Score: 160.03  E-value: 8.99e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 80861398     6 VHWFRKGLRLHDNPALKECIQGADTIRcVYILDPWFAGSSNVG-INRWrFLLQCLEDLDANLRKLNSRLFVIRGQPA-DV 83
Cdd:TIGR02766   1 IVWFRRDLRVEDNPALAAAARAGPVIP-VFVWAPEEEGQYYPGrVSRW-WLKQSLAHLDQSLRSLGTCLVTIRSTDTvAA 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 80861398    84 FPRLFKEWNITKLSIEYDSEPFGKERDAAIKKLATEAGVEVIVRISHTLYDLDKIIElNGGQPPLTYKRF--QTLVSKME 161
Cdd:TIGR02766  79 LLDCVRSTGATRLFFNHLYDPVSLVRDHRAKEVLTAQGISVQSFNADLLYEPWEVYD-ELGRPFTMFAAFweRCLSMPYD 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 80861398   162 PLEM--PADTITSDVIGKCttplsddhdekygvpSLEELGFDTD------GLSSAVWPGGETEALTRLERHLERKawVAN 233
Cdd:TIGR02766 158 PESPllPPKKIISGDVSKC---------------SADDLGFEDDsekgsnALLARAWSPGWSNADKALTEFINGP--LLE 220
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 80861398   234 FERPRMNANSllASPTGLSPYLRFGCLSCRLFY--FKLTDLYKKVKKNS----SPPLSLYGQLLwREFFYTAATNNPRFD 307
Cdd:TIGR02766 221 YSKNRKKADS--ATTSLLSPYLHFGEVSVRKVFhlVRMKQIAWANEGNSageeSVNLFLRSIGL-REYSRYISFNHPFSH 297
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 80861398   308 KMEGNPICVQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGdLWISWEEGMKVFEELLLD 387
Cdd:TIGR02766 298 EKPLLGHLKFFPWAVDENYFKAWRQGRTGYPLVDAGMRELWATGWLHDRIRVVVSSFFVKV-LQLPWRWGMKYFWDTLLD 376
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 80861398   388 ADWSINAGSWMWLSCS-SFFQQFFHCYCPVGFGRRTDPNGDYIRRYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGVNY 466
Cdd:TIGR02766 377 ADLESDALGWQYISGSlPDGRELDRIDNPQLEGYKFDPNGEYVRRWLPELARLPTEWIHHPWDAPESVLQAAGVELGSNY 456
                         490
                  ....*....|
gi 80861398   467 PKPMVNHAEA 476
Cdd:TIGR02766 457 PLPIVGLDEA 466
PRK10674 PRK10674
deoxyribodipyrimidine photolyase; Provisional
8-476 6.71e-42

deoxyribodipyrimidine photolyase; Provisional


Pssm-ID: 236734 [Multi-domain]  Cd Length: 472  Bit Score: 157.49  E-value: 6.71e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 80861398    8 WFRKGLRLHDNPALKECIQGAD-TIRCVYILDPwfagssnvgiNRWR----------FLLQCLEDLDANLRKLNSRLFVI 76
Cdd:PRK10674   7 WFRNDLRLHDNLALAAACRDPSaRVLALFIATP----------AQWAahdmaprqaaFINAQLNALQIALAEKGIPLLFH 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 80861398   77 rgQPADvfprlFK---EW--------NITKLSIEYDSEPFGKERDAAIKKLATEagveVIVRISHtlydlDKIIelnggQ 145
Cdd:PRK10674  77 --EVDD-----FAasvEWlkqfcqqhQVTHLFYNYQYEVNERQRDAAVERALRN----VVCQGFD-----DSVL-----L 135
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 80861398  146 PP---LT-----YKRF--------QTLVSKMePLEMPADTITSDviGKCTTPlsddhdekygvpSLEELGFDTDGLSSAV 209
Cdd:PRK10674 136 PPgsvMTgnhemYKVFtpfknaflKRLREGD-PECVPAPKVRSS--GAIEPL------------PPIPFNYPQQSFDTAL 200
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 80861398  210 WPGGETEALTRLeRHLERKAwVANFERPRmnanSLLASP--TGLSPYLRFGCLSCRLFYFKLTDLYKKVKKNSSPPLSLy 287
Cdd:PRK10674 201 FPVGEKAAIAQL-RQFCQQG-AGEYEQQR----DFPAVDgtSRLSAYLATGVLSPRQCLHRLLAEQPQALDGGAGSVWL- 273
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 80861398  288 GQLLWREFFYTAATNNPRfdkmegnpICVQIP---------WDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLAR 358
Cdd:PRK10674 274 NELIWREFYRHLMVAYPS--------LCKHRPfiawtdrvqWQSNPAHLQAWQQGKTGYPIVDAAMRQLNSTGWMHNRLR 345
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 80861398  359 HAVACFLTRgDLWISWEEGMKVFEELLLDADWSINAGSWMW-LSCSSFFQQFFHCYCPVGFGRRTDPNGDYIRRYLPVLR 437
Cdd:PRK10674 346 MITASFLVK-DLLIDWREGERYFMSQLIDGDLAANNGGWQWaASTGTDAAPYFRIFNPTTQGERFDRDGEFIRRWLPELR 424
                        490       500       510
                 ....*....|....*....|....*....|....*....
gi 80861398  438 GFPAKYIYDPWNAPEGIQKVakcligVNYPKPMVNHAEA 476
Cdd:PRK10674 425 DVPGKAIHQPWRWAEKAGVT------LDYPQPIVDHKQA 457
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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