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Conserved domains on  [gi|38348206|ref|NP_940847|]
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ras and Rab interactor-like protein isoform 2 [Homo sapiens]

Protein Classification

VPS9 domain-containing protein( domain architecture ID 10490879)

VPS9 domain-containing protein similar to Homo sapiens VPS9 domain-containing protein 1 that regulates tubular endosome formation through specific activation of Rab22A

Gene Ontology:  GO:0031267|GO:0005085|GO:0005096|GO:0016192
PubMed:  17450153

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
VPS9 pfam02204
Vacuolar sorting protein 9 (VPS9) domain; This domain acts as a GDP-GTP exchange factor (GEF). ...
 295-397 2.05e-26

Vacuolar sorting protein 9 (VPS9) domain; This domain acts as a GDP-GTP exchange factor (GEF). It activates Rab GTPases by stimulating the release of GDP and allowing GTP to bind.


:

Pssm-ID: 460489  Cd Length: 104  Bit Score: 102.29  E-value: 2.05e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348206   295 RIHERLAHLHAACAPRRKVALLLEVCRDVYAGLARGENQDPLGADAFLPALTEELIWSPdIGDTQLDVEFLMELLDPDEL 374
Cdd:pfam02204   3 QAQQELKKLNEAKSPREKLKCLLRTCKLITEALSKSNRDESLGADDLLPILIYVLIRAN-PPNLYSNLQFISEFRDPDLL 81

                          90       100
                  ....*....|....*....|...
gi 38348206   375 RGEAGYYLTTWFGALHHIAHYQP 397
Cdd:pfam02204  82 SGEEGYYLTTLEAALEFIESLDP 104
 
Name Accession Description Interval E-value
VPS9 pfam02204
Vacuolar sorting protein 9 (VPS9) domain; This domain acts as a GDP-GTP exchange factor (GEF). ...
 295-397 2.05e-26

Vacuolar sorting protein 9 (VPS9) domain; This domain acts as a GDP-GTP exchange factor (GEF). It activates Rab GTPases by stimulating the release of GDP and allowing GTP to bind.


Pssm-ID: 460489  Cd Length: 104  Bit Score: 102.29  E-value: 2.05e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348206   295 RIHERLAHLHAACAPRRKVALLLEVCRDVYAGLARGENQDPLGADAFLPALTEELIWSPdIGDTQLDVEFLMELLDPDEL 374
Cdd:pfam02204   3 QAQQELKKLNEAKSPREKLKCLLRTCKLITEALSKSNRDESLGADDLLPILIYVLIRAN-PPNLYSNLQFISEFRDPDLL 81

                          90       100
                  ....*....|....*....|...
gi 38348206   375 RGEAGYYLTTWFGALHHIAHYQP 397
Cdd:pfam02204  82 SGEEGYYLTTLEAALEFIESLDP 104
VPS9 smart00167
Domain present in VPS9; Domain present in yeast vacuolar sorting protein 9 and other proteins.
 309-392 6.87e-12

Domain present in VPS9; Domain present in yeast vacuolar sorting protein 9 and other proteins.


Pssm-ID: 128469  Cd Length: 117  Bit Score: 62.09  E-value: 6.87e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348206    309 PRRKVALLLEVCRDVYAGLARGENQDpLGADAFLPALTEELIwSPDIGDTQLDVEFLMELLDPDELRGEAGYYLTTWFGA 388
Cdd:smart00167  18 PSDKIKCLLRACKLIYTLLETQSGEV-AGADDFLPVLIYVII-KCDPRDLLLNAEYMEEFLEPSLLTGEGGYYLTSLSAA 95


                   ....
gi 38348206    389 LHHI 392
Cdd:smart00167  96 LALI 99
 
Name Accession Description Interval E-value
VPS9 pfam02204
Vacuolar sorting protein 9 (VPS9) domain; This domain acts as a GDP-GTP exchange factor (GEF). ...
 295-397 2.05e-26

Vacuolar sorting protein 9 (VPS9) domain; This domain acts as a GDP-GTP exchange factor (GEF). It activates Rab GTPases by stimulating the release of GDP and allowing GTP to bind.


Pssm-ID: 460489  Cd Length: 104  Bit Score: 102.29  E-value: 2.05e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348206   295 RIHERLAHLHAACAPRRKVALLLEVCRDVYAGLARGENQDPLGADAFLPALTEELIWSPdIGDTQLDVEFLMELLDPDEL 374
Cdd:pfam02204   3 QAQQELKKLNEAKSPREKLKCLLRTCKLITEALSKSNRDESLGADDLLPILIYVLIRAN-PPNLYSNLQFISEFRDPDLL 81

                          90       100
                  ....*....|....*....|...
gi 38348206   375 RGEAGYYLTTWFGALHHIAHYQP 397
Cdd:pfam02204  82 SGEEGYYLTTLEAALEFIESLDP 104
VPS9 smart00167
Domain present in VPS9; Domain present in yeast vacuolar sorting protein 9 and other proteins.
 309-392 6.87e-12

Domain present in VPS9; Domain present in yeast vacuolar sorting protein 9 and other proteins.


Pssm-ID: 128469  Cd Length: 117  Bit Score: 62.09  E-value: 6.87e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348206    309 PRRKVALLLEVCRDVYAGLARGENQDpLGADAFLPALTEELIwSPDIGDTQLDVEFLMELLDPDELRGEAGYYLTTWFGA 388
Cdd:smart00167  18 PSDKIKCLLRACKLIYTLLETQSGEV-AGADDFLPVLIYVII-KCDPRDLLLNAEYMEEFLEPSLLTGEGGYYLTSLSAA 95


                   ....
gi 38348206    389 LHHI 392
Cdd:smart00167  96 LALI 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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