|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
2-897 |
0e+00 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 1874.72 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 2 DQHEPQRPDPDELLTLVNEKQRGKLKIFFGACAGVGKTYAMLQEAQRLRAQGLDVVIGVVETHERQGTAALLDGLPQLPL 81
Cdd:PRK10490 1 MNNEPLRPDPDRLLEQTAEPHRGKLKIFFGACAGVGKTYAMLQEAQRLRAQGLDVLVGVVETHGRKETAALLEGLTVLPP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 82 KQIYYRRRKISVFDLDAAIARHPAIILMDELAFSNPHTNRHPKRWQDVEELLEAGIDVLTTINVQHLESLNDVVGDITGI 161
Cdd:PRK10490 81 KRIHHRGRHISEFDLDAALARRPALILMDELAHSNAPGSRHPKRWQDVEELLEAGIDVFTTVNVQHLESLNDVVGGVTGI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 162 RVRETIPDHIFDQANEIVLVDLPPDDLRQRLNEGKVYIPSQAERAIEHFFRKGNLIALRELALRRTADRVDDQMRAFRDT 241
Cdd:PRK10490 161 QVRETVPDPFFDAADEVVLVDLPPDDLRQRLNEGKVYIAGQAERAIEHFFRKGNLIALRELALRRTADRVDDQMRAWRDH 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 242 QGHEPVWHTRDNLLLCIGNSSGNEKLIRTAARLAARLGCIWHAIYVETPKLYQLPEGKRRSILKALRLAHELGAETATLS 321
Cdd:PRK10490 241 QGEEKVWHTRDAILLCIGHNTGSEKLVRTAARLAARLGSVWHAVYVETPRLHRLPEKKRRAILSALRLAQELGAETATLS 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 322 DPNKEKAVLRYAREHNLGKILIGRRCTSKqklfgWQWRSGFADRLGKLGPDLDLVIVALEER--SHWDKEQDNRSVSEKW 399
Cdd:PRK10490 321 DPAEEKAVLRYAREHNLGKIIIGRRASRR-----WWRRESFADRLARLGPDLDLVIVALDEPpaRAIAKAPDSRPFKEKW 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 400 RVQIQGCLIAIALCTLITLFSRTFLLTLDKANLVTLYLLGVVVIALFYGRRPSIFAAFINVISFDIFFVQPHWSLAVTDM 479
Cdd:PRK10490 396 RVQIQGCLVAIALCALITLIAMQWLPAFDAANLVMLYLLGVVVVALFYGRWPSVVATVINVASFDLFFVAPRGTLAVSDV 475
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 480 QYLLTFSVMLIVGVVVGNLTAGMRYQARIARYREQRTRNLYEMTRELSRALNEEDIARTSYHFLTNGFQAKTGLFLPNDD 559
Cdd:PRK10490 476 QYLLTFAVMLTVGLVIGNLTAGVRYQARVARYREQRTRHLYEMSKALAVGLSPEDIAATSEHFLASTFQARSQLLLPDDN 555
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 560 GNLYQLTTNNgGHMLIDDAIAKWSFDKNLPAGAGTDTLPSVPYQLQPIATPSQTLAVLAIEPSYLRQLLIPEQQRLLQTF 639
Cdd:PRK10490 556 GKLQPLTHDQ-GMTPWDDAIARWSFDKGQPAGAGTDTLPGVPYQILPLKSAQKTYGLLAVEPGNLRQLMIPEQQRLLETF 634
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 640 TGLIANALERLQLSRRAESAKLDTEREQLRNSLLAALSHDLRTPLTVLFGQAEILMLDLSAEGSPHTKQVNQIRQQILST 719
Cdd:PRK10490 635 TLLIANALERLTLTASEEQARLASEREQLRNALLAALSHDLRTPLTVLFGQAEILTLDLASEGSPHARQASEIRQQVLNT 714
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 720 SRLVNNLLDMARIQSGGIQLNLEWQSLEEIVGSTLRSLEYALNRHPVAVSLPSDL-LLHCDASLLERVFINLLENAIKYT 798
Cdd:PRK10490 715 TRLVNNLLDMARIQSGGFNLRKEWLTLEEVVGSALQMLEPGLSGHPINLSLPEPLtLIHVDGPLFERVLINLLENAVKYA 794
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 799 DEQIPLGIKATTEKNQIHIEVWDAGKGIPPEQEQLIFDKFSRARKESAIPGVGLGLAICRAIIEIHQGKIWASNNEKGGA 878
Cdd:PRK10490 795 GAQAEIGIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDKFARGNKESAIPGVGLGLAICRAIVEVHGGTIWAENRPEGGA 874
|
890 900
....*....|....*....|.
gi 37525371 879 SFHFVLPLEKPPEI--ITEEM 897
Cdd:PRK10490 875 CFRVTLPLETPPELeeFHEDM 895
|
|
| KdpD |
pfam02702 |
Osmosensitive K+ channel His kinase sensor domain; This is a family of KdpD sensor kinase ... |
22-231 |
4.88e-135 |
|
Osmosensitive K+ channel His kinase sensor domain; This is a family of KdpD sensor kinase proteins that regulate the kdpFABC operon responsible for potassium transport. The aligned region corresponds to the N-terminal cytoplasmic part of the protein which functions as the sensor domain responsible for sensing turgor pressure. It recognizes C-di-AMP and K+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 460656 [Multi-domain] Cd Length: 210 Bit Score: 401.41 E-value: 4.88e-135
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 22 QRGKLKIFFGACAGVGKTYAMLQEAQRLRAQGLDVVIGVVETHERQGTAALLDGLPQLPLKQIYYRRRKISVFDLDAAIA 101
Cdd:pfam02702 1 RRGRLKIFLGAAPGVGKTYAMLQEAHRLKKRGVDVVIGYVETHGRPETEALLEGLEVIPRREIEYRGRTLEEMDLDAILA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 102 RHPAIILMDELAFSNPHTNRHPKRWQDVEELLEAGIDVLTTINVQHLESLNDVVGDITGIRVRETIPDHIFDQANEIVLV 181
Cdd:pfam02702 81 RRPEVVLVDELAHTNAPGSRHPKRWQDVEELLDAGIDVYTTVNIQHLESLNDVVEQITGVRVRETVPDSVLDRADEVELV 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 37525371 182 DLPPDDLRQRLNEGKVYIPSQAERAIEHFFRKGNLIALRELALRRTADRV 231
Cdd:pfam02702 161 DLTPEELLERLKEGKVYPPEKAERALKNFFRKGNLTALRELALRRVADRV 210
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
651-889 |
3.03e-77 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 251.36 E-value: 3.03e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 651 QLSRRAESAKldtEREQLRNSLLAALSHDLRTPLTVLFGQAEILMLDLSAEGSPHTKQVNQIRQQILSTSRLVNNLLDMA 730
Cdd:COG2205 1 ELEEALEELE---ELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERRELLEIIRESAERLLRLIEDLLDLS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 731 RIQSGGIQLNLEWQSLEEIVGSTLRSLEYALNRHPVAVSL---PSDLLLHCDASLLERVFINLLENAIKYTDEQIPLGIK 807
Cdd:COG2205 78 RLESGKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELdlpPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITIS 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 808 ATTEKNQIHIEVWDAGKGIPPEQEQLIFDKFSRARKESAIPGVGLGLAICRAIIEIHQGKIWASNNEKGGASFHFVLPLE 887
Cdd:COG2205 158 ARREGDGVRISVSDNGPGIPEEELERIFERFYRGDNSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPLA 237
|
..
gi 37525371 888 KP 889
Cdd:COG2205 238 ES 239
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
498-889 |
2.62e-61 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 213.26 E-value: 2.62e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 498 LTAGMRYQARIARYREQRTRNLYEMTRELSRALNEEDIARTSYHFLTNGFQAKTGLFLPNDDGNLYQLTTNNGGHMLIDD 577
Cdd:COG5002 1 LLLLLLLLLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 578 AIAKWSFDKNLPAGAGTDTLPSVPYQLQPIATPSQTLAVLAIEPSYLRQLLIPEQQRLLQTFTGLIANALERLQLSRRAE 657
Cdd:COG5002 81 LALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELER 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 658 SakldterEQLRNSLLAALSHDLRTPLTVLFGQAEILMLDLSAEGSPHTKQVNQIRQQILSTSRLVNNLLDMARIQSGGI 737
Cdd:COG5002 161 L-------EQMRREFVANVSHELRTPLTSIRGYLELLLDGAADDPEERREYLEIILEEAERLSRLVNDLLDLSRLESGEL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 738 QLNLEWQSLEEIVGSTLRSLEYALNRHPVAVSL---PSDLLLHCDASLLERVFINLLENAIKYTDEQIPLGIKATTEKNQ 814
Cdd:COG5002 234 KLEKEPVDLAELLEEVVEELRPLAEEKGIELELdlpEDPLLVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLREEDDQ 313
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 37525371 815 IHIEVWDAGKGIPPEQEQLIFDKFSRARKE--SAIPGVGLGLAICRAIIEIHQGKIWASNNEKGGASFHFVLPLEKP 889
Cdd:COG5002 314 VRISVRDTGIGIPEEDLPRIFERFYRVDKSrsRETGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITLPLARE 390
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
574-887 |
1.67e-59 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 206.30 E-value: 1.67e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 574 LIDDAIAKWSFDKNLPAGAGTDTLPSVPYQLQPIATPSQTLAVLAIEPSYLRQLLIPEQQRLLQTFTGLIANALERLQLS 653
Cdd:COG0642 18 LLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 654 RRAESAKldtEREQLRNSLLAALSHDLRTPLTVLFGQAEILMLDLSAEgspHTKQVNQIRQQILSTSRLVNNLLDMARIQ 733
Cdd:COG0642 98 ALLLLLE---EANEAKSRFLANVSHELRTPLTAIRGYLELLLEELDEE---QREYLETILRSADRLLRLINDLLDLSRLE 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 734 SGGIQLNLEWQSLEEIVGSTLRSLEYALNRHPVAVSL---PSDLLLHCDASLLERVFINLLENAIKYTDEQIPLGIKATT 810
Cdd:COG0642 172 AGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELdlpDDLPTVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVSVRR 251
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 37525371 811 EKNQIHIEVWDAGKGIPPEQEQLIFDKFSRARKESAIPGVGLGLAICRAIIEIHQGKIWASNNEKGGASFHFVLPLE 887
Cdd:COG0642 252 EGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRGGGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTLPLA 328
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
399-889 |
3.55e-45 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 170.74 E-value: 3.55e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 399 WRVQIQGCLIAIALCTLITLFSRTFLLTLDKANLVTLYLLGVVVIALFYGRRPSIFAAFINVISFDIFFVQPHWSLAVTD 478
Cdd:COG4251 8 LLLLLLLLLLLLLLLLLLLVLLLALALLLLLALLVLLLLLIRLLLLLLLSLLALLLLLLLLLLLLLVLAALALLLLLLLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 479 MQYLLTFSVMLIVGVVVGNLTAGMRYQARIARYREQRTRNLYEMTRELSRALNEEDIARTSYHFLTNGFQAKTGLFLPND 558
Cdd:COG4251 88 ELALVLLALLLVLLLLLALLLLLALLLLLELLLLLLALLLLLLLLALLLLEELALLRLALALLLLLLLLLLLLLLLLALI 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 559 DGNLYQLTTNNGGHMLIDDAIAKWSFDKNLPAGAGTDTLPSVPYQLQPIATPSQTLAVLAIEPSYLRQLLIPEQQRLLQT 638
Cdd:COG4251 168 LALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLLLILLLLL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 639 FTGLIANALERLQLSRRAESAKLDTEREQLRNSLLAAL----SHDLRTPLTVLFGQAEILMLDLSAEGSPHTKQ-VNQIR 713
Cdd:COG4251 248 LILVLELLELRLELEELEEELEERTAELERSNEELEQFayvaSHDLREPLRKISGFSQLLEEDYGDKLDEEGREyLERIR 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 714 QQILSTSRLVNNLLDMARIQSGgiQLNLEWQSLEEIVGSTLRSLEYALNRHPVAVSLPSDLLLHCDASLLERVFINLLEN 793
Cdd:COG4251 328 DAAERMQALIDDLLAYSRVGRQ--ELEFEPVDLNELLEEVLEDLEPRIEERGAEIEVGPLPTVRGDPTLLRQVFQNLISN 405
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 794 AIKYTDEQIP--LGIKATTEKNQIHIEVWDAGKGIPPEQEQLIFDKFSRARKESAIPGVGLGLAICRAIIEIHQGKIWAS 871
Cdd:COG4251 406 AIKYSRPGEPprIEIGAEREGGEWVFSVRDNGIGIDPEYAEKIFEIFQRLHSRDEYEGTGIGLAIVKKIVERHGGRIWVE 485
|
490
....*....|....*...
gi 37525371 872 NNEKGGASFHFVLPLEKP 889
Cdd:COG4251 486 SEPGEGATFYFTLPKAPA 503
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
614-886 |
6.10e-40 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 151.49 E-value: 6.10e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 614 LAVLAIEPSYLRQLLIPEQQRLLQTFTGLIANALERLQLSRRAESAKLDTEREQLRNS--------LLAALSHDLRTPLT 685
Cdd:COG4191 79 LLLLGLLLLLLLEALLLLLLAALDAEENAELEELERDITELERAEEELRELQEQLVQSeklaalgeLAAGIAHEINNPLA 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 686 VLFGQAEILMLDLSAEGSPH--TKQVNQIRQQILSTSRLVNNLLDMARIQSggiqLNLEWQSLEEIVGSTLRSLEYALNR 763
Cdd:COG4191 159 AILGNAELLRRRLEDEPDPEelREALERILEGAERAAEIVRSLRAFSRRDE----EEREPVDLNELIDEALELLRPRLKA 234
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 764 HPVAVSL---PSDLLLHCDASLLERVFINLLENAIKYTDEQIP--LGIKATTEKNQIHIEVWDAGKGIPPEQEQLIFDKF 838
Cdd:COG4191 235 RGIEVELdlpPDLPPVLGDPGQLEQVLLNLLINAIDAMEEGEGgrITISTRREGDYVVISVRDNGPGIPPEVLERIFEPF 314
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 37525371 839 --SRARKEsaipGVGLGLAICRAIIEIHQGKIWASNNEKGGASFHFVLPL 886
Cdd:COG4191 315 ftTKPVGK----GTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLPL 360
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
672-891 |
2.32e-39 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 151.65 E-value: 2.32e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 672 LLAALSHDLRTPLTVLFGQAEILMLDLSAEGSPHTKQVNQ----IRQQILSTSRLVNNLLDMARIQsggiQLNLEWQSLE 747
Cdd:COG5000 204 LARRIAHEIKNPLTPIQLSAERLRRKLADKLEEDREDLERaldtIIRQVDRLKRIVDEFLDFARLP----EPQLEPVDLN 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 748 EIVGSTLRSLEYALNRHPVAVSL---PSDLLLHCDASLLERVFINLLENAIKYTDEQIPLGIKATTEKNQIHIEVWDAGK 824
Cdd:COG5000 280 ELLREVLALYEPALKEKDIRLELdldPDLPEVLADRDQLEQVLINLLKNAIEAIEEGGEIEVSTRREDGRVRIEVSDNGP 359
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 37525371 825 GIPPEQEQLIFDKF--SRARkesaipGVGLGLAICRAIIEIHQGKIWASNNEKGGASFHFVLPLEKPPE 891
Cdd:COG5000 360 GIPEEVLERIFEPFftTKPK------GTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRLPLAEEAE 422
|
|
| DUF4118 |
pfam13493 |
Domain of unknown function (DUF4118); This domain is found in a wide variety of bacterial ... |
407-512 |
4.03e-37 |
|
Domain of unknown function (DUF4118); This domain is found in a wide variety of bacterial signalling proteins. It is likely to be a transmembrane domain involved in ligand sensing.
Pssm-ID: 463897 Cd Length: 107 Bit Score: 134.89 E-value: 4.03e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 407 LIAIALCTLITLFSRTFLLTLDKANLVTLYLLGVVVIALFYGRRPSIFAAFINVISFDIFFVQPHWSLAVTDMQYLLTFS 486
Cdd:pfam13493 2 LLAVLILALATLLALLLRPLLPLANIALLFLLAVLLVALRGGRGPGLLAAVLSVLLFNYFFTPPYFTFTVSDPGYLLTLV 81
|
90 100
....*....|....*....|....*.
gi 37525371 487 VMLIVGVVVGNLTAGMRYQARIARYR 512
Cdd:pfam13493 82 VFLLVALLTSTLTARLRRQARQARRR 107
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
779-887 |
2.25e-35 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 130.08 E-value: 2.25e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 779 DASLLERVFINLLENAIKYTDEQIPLGIKATTEKNQIHIEVWDAGKGIPPEQEQLIFDKFSRARK-ESAIPGVGLGLAIC 857
Cdd:smart00387 2 DPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKrSRKIGGTGLGLSIV 81
|
90 100 110
....*....|....*....|....*....|
gi 37525371 858 RAIIEIHQGKIWASNNEKGGASFHFVLPLE 887
Cdd:smart00387 82 KKLVELHGGEISVESEPGGGTTFTITLPLE 111
|
|
| USP_KdpD-like |
cd01987 |
USP domain of the osmosensitive K+ channel histidine kinase family; The KdpDE two component ... |
254-379 |
1.01e-34 |
|
USP domain of the osmosensitive K+ channel histidine kinase family; The KdpDE two component system is widespread in bacteria and archaea; it controls potassium homeostasis and virulence by regulating the transcription of multiple genes, including a kdpFABC operon, which encodes a high-affinity P-type ATPase transporter. The KdpD histidine kinase (HK, EC:2.7.13.3) contain an N-terminal sensory cytoplasmic region (NTR) composed of KdpD' and universal stress protein (USP) domains, a canonical transmembrane domain, and a cytoplasmic C-terminal region with a transmitter GAF domain and an EnvZ-like catalytic HK domain. Proteins containing the USP domain are induced by many environmental stressors such as nutrient starvation, drought, extreme temperatures, high salinity, and the presence of uncouplers, antibiotics, and metals. It enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity.
Pssm-ID: 467491 [Multi-domain] Cd Length: 124 Bit Score: 128.52 E-value: 1.01e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 254 LLLCIGNSSGNEKLIRTAARLAARLGCIWHAIYVETPKLYQLPEGKRRSILKALRLAHELGAETATLSDPNKEKAVLRYA 333
Cdd:cd01987 2 ILVCISSSPTSEKLIRRAARLAERLNGELTAVYVETPEESRLDEESQRRLLTNLKLAEELGAEVVSVEGDDVAEAIVEFA 81
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 37525371 334 REHNLGKILIGRrctSKQKLFGWQWRSGFADRLGKLGPDLDLVIVA 379
Cdd:cd01987 82 RERNVTQIVLGQ---SRRRRWRRLFKGSLVDRLLREAPNIDVHIVP 124
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
610-885 |
2.04e-32 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 130.07 E-value: 2.04e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 610 PSQTLAVLAIepsyLRQL--LIPEQQRLLQTFTGLIAN-----------ALERLQLSR-----RAESAKLdTEREQLRNS 671
Cdd:PRK09303 79 PRQVLAGSNI----FQQLknWWPRWQQEGATYSGLGENlqpseidsgrySQELLQLSDelfvlRQENETL-LEQLKFKDR 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 672 LLAALSHDLRTPLTvlfgqAEILMLDlsaegsphTKQVNQIRQQILSTSRLVNNLLDMARIQsggiqlnlewqsLEEI-- 749
Cdd:PRK09303 154 VLAMLAHDLRTPLT-----AASLALE--------TLELGQIDEDTELKPALIEQLQDQARRQ------------LEEIer 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 750 -------VGSTlRSLEYALNRHPVAVS------------------------LPSDL-LLHCDASLLERVFINLLENAIKY 797
Cdd:PRK09303 209 litdlleVGRT-RWEALRFNPQKLDLGslcqevilelekrwlaksleiqtdIPSDLpSVYADQERIRQVLLNLLDNAIKY 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 798 TDE--QIPLGI-KATTEKNQIHIEvwDAGKGIPPEQEQLIFDKFSRARKESAIPGVGLGLAICRAIIEIHQGKIWASNNE 874
Cdd:PRK09303 288 TPEggTITLSMlHRTTQKVQVSIC--DTGPGIPEEEQERIFEDRVRLPRDEGTEGYGIGLSVCRRIVRVHYGQIWVDSEP 365
|
330
....*....|.
gi 37525371 875 KGGASFHFVLP 885
Cdd:PRK09303 366 GQGSCFHFTLP 376
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
783-884 |
5.91e-32 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 119.63 E-value: 5.91e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 783 LERVFINLLENAIKYTDEQIPLGIKATTEKNQIHIEVWDAGKGIPPEQEQLIFDKFSRARKESAIPGVGLGLAICRAIIE 862
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSREGGGTGLGLAIVRRIVE 80
|
90 100
....*....|....*....|..
gi 37525371 863 IHQGKIWASNNEKGGASFHFVL 884
Cdd:cd00075 81 AHGGRITVESEPGGGTTFTVTL 102
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
631-891 |
7.89e-30 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 123.97 E-value: 7.89e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 631 EQQRLLQTFTGLiANALERlqlsrraesakldteREQLRNSLLAALSHDLRTPLTVLFGQAEIL-----------MLDLS 699
Cdd:PRK10549 218 ELGRLAQDFNQL-ASTLEK---------------NEQMRRDFMADISHELRTPLAVLRGELEAIqdgvrkftpesVASLQ 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 700 AEGSPHTKQVNQIRQQILS---------TSRLVNNLLDMA------RIQSGGIQLNLewqsleeivgstlrsleyalnrh 764
Cdd:PRK10549 282 AEVGTLTKLVDDLHQLSLSdegalayrkTPVDLVPLLEVAggafreRFASRGLTLQL----------------------- 338
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 765 pvavSLPSDLLLHCDASLLERVFINLLENAIKYTDEQIPLGIKATTEKNQIHIEVWDAGKGIPPEQEQLIFDKFSRArkE 844
Cdd:PRK10549 339 ----SLPDSATVFGDPDRLMQLFNNLLENSLRYTDSGGSLHISAEQRDKTLRLTFADSAPGVSDEQLQKLFERFYRT--E 412
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 37525371 845 S----AIPGVGLGLAICRAIIEIHQGKIWASNNEKGGASFHFVLPLEKPPE 891
Cdd:PRK10549 413 GsrnrASGGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPLERDLQ 463
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
779-888 |
1.09e-29 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 113.62 E-value: 1.09e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 779 DASLLERVFINLLENAIKYTDEQIPLGIKATtEKNQIHIEVWDAGKGIPPEQEQLIFDKFSRARKESAiPGVGLGLAICR 858
Cdd:pfam02518 2 DELRLRQVLSNLLDNALKHAAKAGEITVTLS-EGGELTLTVEDNGIGIPPEDLPRIFEPFSTADKRGG-GGTGLGLSIVR 79
|
90 100 110
....*....|....*....|....*....|
gi 37525371 859 AIIEIHQGKIWASNNEKGGASFHFVLPLEK 888
Cdd:pfam02518 80 KLVELLGGTITVESEPGGGTTVTLTLPLAQ 109
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
663-895 |
1.66e-28 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 120.46 E-value: 1.66e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 663 TER----EQLRNS--------LLAALSHDLRTPLTVLFGQAEILMLDLSAEGSPH----TKQVNQIRQqilstsrLVNNL 726
Cdd:COG5809 252 TERkkleELLRKSeklsvvgeLAAGIAHEIRNPLTSLKGFIQLLKDTIDEEQKTYldimLSELDRIES-------IISEF 324
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 727 LDMARIQSGGIQLNlewqSLEEIVGSTLRSLEYALNRHPVAVSLPSDL---LLHCDASLLERVFINLLENAIKYTDEQIP 803
Cdd:COG5809 325 LVLAKPQAIKYEPK----DLNTLIEEVIPLLQPQALLKNVQIELELEDdipDILGDENQLKQVFINLLKNAIEAMPEGGN 400
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 804 LGIKAT-TEKNQIHIEVWDAGKGIPPEQEQLIFDKFSrARKESaipGVGLGLAICRAIIEIHQGKIWASNNEKGGASFHF 882
Cdd:COG5809 401 ITIETKaEDDDKVVISVTDEGCGIPEERLKKLGEPFY-TTKEK---GTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSI 476
|
250
....*....|...
gi 37525371 883 VLPLEKPPEIITE 895
Cdd:COG5809 477 TLPIKLSEQVSMN 489
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
648-891 |
1.57e-27 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 115.33 E-value: 1.57e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 648 ERLQLSRR-AESAKLDTEREqlrnsLLAALSHDLRTPLTVLFGQAEILMLDLSAEgsPHTKQVNQIRQQILSTSRLVNNL 726
Cdd:COG3852 118 ERKRLERElRRAEKLAAVGE-----LAAGLAHEIRNPLTGIRGAAQLLERELPDD--ELREYTQLIIEEADRLNNLVDRL 190
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 727 LDMARIQsggiQLNLEWQSLEEIVGSTLRSLEYALNRHpVAVSL---PSDLLLHCDASLLERVFINLLENAIKYTDE--- 800
Cdd:COG3852 191 LSFSRPR----PPEREPVNLHEVLERVLELLRAEAPKN-IRIVRdydPSLPEVLGDPDQLIQVLLNLVRNAAEAMPEggt 265
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 801 -------QIPLGIKATTEKNQIHIEVWDAGKGIPPEQEQLIFDKFSRARKEsaipGVGLGLAICRAIIEIHQGKIWASNN 873
Cdd:COG3852 266 itirtrvERQVTLGGLRPRLYVRIEVIDNGPGIPEEILDRIFEPFFTTKEK----GTGLGLAIVQKIVEQHGGTIEVESE 341
|
250
....*....|....*...
gi 37525371 874 EKGGASFHFVLPLEKPPE 891
Cdd:COG3852 342 PGKGTTFRIYLPLEQAEE 359
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
783-886 |
5.57e-27 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 105.87 E-value: 5.57e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 783 LERVFINLLENAIKYTDEQIPLGIkaTTEKNQIHIEVWDAGKGIPPEQEQLIFDKFSRA--RKESAIPGVGLGLAICRAI 860
Cdd:cd16949 1 LARALENVLRNALRYSPSKILLDI--SQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVdsARDRESGGTGLGLAIAERA 78
|
90 100
....*....|....*....|....*.
gi 37525371 861 IEIHQGKIWASNNEKGGASFHFVLPL 886
Cdd:cd16949 79 IEQHGGKIKASNRKPGGLRVRIWLPA 104
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
783-886 |
9.20e-24 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 96.79 E-value: 9.20e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 783 LERVFINLLENAIKYTDE-QIPLGIKA---TTEKNQIHIEVWDAGKGIPPEQEQLIFDKFSRA-----RKESaipGVGLG 853
Cdd:cd16922 1 LRQILLNLLGNAIKFTEEgEVTLRVSLeeeEEDGVQLRFSVEDTGIGIPEEQQARLFEPFSQAdssttRKYG---GTGLG 77
|
90 100 110
....*....|....*....|....*....|...
gi 37525371 854 LAICRAIIEIHQGKIWASNNEKGGASFHFVLPL 886
Cdd:cd16922 78 LAISKKLVELMGGDISVESEPGQGSTFTFTLPL 110
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
663-889 |
1.64e-23 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 106.21 E-value: 1.64e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 663 TEREQLRNSL-----LAAL-------SHDLRTPLTVLFGQAEILMLdlSAEGSPHTKQVNQIRQQILSTSRLVNNLLDMA 730
Cdd:PRK11360 372 TERKRLQRRVarqerLAALgelvagvAHEIRNPLTAIRGYVQIWRQ--QTSDPPSQEYLSVVLREVDRLNKVIDQLLEFS 449
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 731 RIQsggiQLNLEWQSLEEIVGSTLRSLEYAL--NRHPVAVSLPSDL-LLHCDASLLERVFINLLENAIkytdEQIPLGIK 807
Cdd:PRK11360 450 RPR----ESQWQPVSLNALVEEVLQLFQTAGvqARVDFETELDNELpPIWADPELLKQVLLNILINAV----QAISARGK 521
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 808 ATTE-----KNQIHIEVWDAGKGIPPEQEQLIFDKF--SRARkesaipGVGLGLAICRAIIEIHQGKIWASNNEKGGASF 880
Cdd:PRK11360 522 IRIRtwqysDGQVAVSIEDNGCGIDPELLKKIFDPFftTKAK------GTGLGLALSQRIINAHGGDIEVESEPGVGTTF 595
|
....*....
gi 37525371 881 HFVLPLEKP 889
Cdd:PRK11360 596 TLYLPINPQ 604
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
657-897 |
3.02e-23 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 106.26 E-value: 3.02e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 657 ESAKLDTEREQLRNSL-LAALSHDLRTPLTVLFGQAEILmldlsaegspHTKQVNQIRQQILSTSR--------LVNNLL 727
Cdd:PRK15347 385 AEAKQRAEQANKRKSEhLTTISHEIRTPLNGVLGALELL----------QNTPLTAEQMDLADTARqctlsllaIINNLL 454
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 728 DMARIQSGGIQLNLEWQSLEEIVGST-----LRSLEYALNRHP-VAVSLPsdLLLHCDASLLERVFINLLENAIKYTDE- 800
Cdd:PRK15347 455 DFSRIESGQMTLSLEETALLPLLDQAmltiqGPAQSKSLTLRTfVGAHVP--LYLHLDSLRLRQILVNLLGNAVKFTETg 532
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 801 QIPLGIKatTEKNQIHIEVWDAGKGIPPEQEQLIFDKFSRARKESAipGVGLGLAICRAIIEIHQGKIWASNNEKGGASF 880
Cdd:PRK15347 533 GIRLRVK--RHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADTHSQ--GTGLGLTIASSLAKMMGGELTLFSTPGVGSCF 608
|
250
....*....|....*....
gi 37525371 881 HFVLPLE--KPPEIITEEM 897
Cdd:PRK15347 609 SLVLPLNeyAPPEPLKGEL 627
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
674-884 |
1.14e-22 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 102.08 E-value: 1.14e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 674 AALSHDLRTPLTVLFGQAEILmldLSAEGS-PHTKQV---NQIRQQILstSRLVNNLLDMARIQSGGIQLNLEWQSLEEI 749
Cdd:TIGR01386 246 ADLAHELRTPLTNLLGQTQVA---LSQPRTgEEYREVlesNLEELERL--SRMVSDMLFLARADNGQLALERVRLDLAAE 320
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 750 VGSTLRSLEYALNRHPVAVSLPSDLLLHCDASLLERVFINLLENAIKYTDEQIPLGIKATTEKNQIHIEVWDAGKGIPPE 829
Cdd:TIGR01386 321 LAKVAEYFEPLAEERGVRIRVEGEGLVRGDPQMFRRAISNLLSNALRHTPDGGTITVRIERRSDEVRVSVSNPGPGIPPE 400
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 37525371 830 QEQLIFDKFSR---ARKESAiPGVGLGLAICRAIIEIHQGKIWAsnnEKGGASFHFVL 884
Cdd:TIGR01386 401 HLSRLFDRFYRvdpARSNSG-EGTGLGLAIVRSIMEAHGGRASA---ESPDGKTRFIL 454
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
783-885 |
1.93e-22 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 92.78 E-value: 1.93e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 783 LERVFINLLENAIKYTDEQIP--LGIKATTEKNQIHIEVWDAGKGIPPEQEQLIFDKFSRARKESAIPGVGLGLAICRAI 860
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRRPprIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLHSREEYEGTGVGLAIVRKI 80
|
90 100
....*....|....*....|....*
gi 37525371 861 IEIHQGKIWASNNEKGGASFHFVLP 885
Cdd:cd16921 81 IERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
783-885 |
2.24e-22 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 92.46 E-value: 2.24e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 783 LERVFINLLENAIKYTDEQIP----LGIKATT-EKNQIHIEVWDAGKGIPPEQEQLIFDKFSRARKEsaipGVGLGLAIC 857
Cdd:cd16920 1 IQQVLINLVRNGIEAMSEGGCerreLTIRTSPaDDRAVTISVKDTGPGIAEEVAGQLFDPFYTTKSE----GLGMGLSIC 76
|
90 100
....*....|....*....|....*...
gi 37525371 858 RAIIEIHQGKIWASNNEKGGASFHFVLP 885
Cdd:cd16920 77 RSIIEAHGGRLSVESPAGGGATFQFTLP 104
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
649-886 |
4.50e-22 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 100.69 E-value: 4.50e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 649 RLQLSRRAESAKLDTEREQLRNSL---------LAALSHDLRTPLTVLFGQAEILMLDLSAEgsphTKQ--VNQIRQQIL 717
Cdd:PRK11100 227 PLPKLGSSELRELAQALESMRVKLegkayveqyVQTLTHELKSPLAAIRGAAELLQEDPPPE----DRArfTGNILTQSA 302
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 718 STSRLVNNLLDMARIQSGGIQLNLEWQSLEEIVGSTLRSLEYALNRHPVAVSL-PSDLLLHCDASLLERVFINLLENAIK 796
Cdd:PRK11100 303 RLQQLIDRLLELARLEQRQELEVLEPVALAALLEELVEAREAQAAAKGITLRLrPDDARVLGDPFLLRQALGNLLDNAID 382
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 797 YTDEQIPLGIKATTEKNQIHIEVWDAGKGIP-PEQEQlIFDKF-SRARKESAIPGVGLGLAICRAIIEIHQGKIWASNNE 874
Cdd:PRK11100 383 FSPEGGTITLSAEVDGEQVALSVEDQGPGIPdYALPR-IFERFySLPRPANGRKSTGLGLAFVREVARLHGGEVTLRNRP 461
|
250
....*....|..
gi 37525371 875 KGGASFHFVLPL 886
Cdd:PRK11100 462 EGGVLATLTLPR 473
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
625-878 |
1.59e-21 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 98.94 E-value: 1.59e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 625 RQLLIPEQQRLLqtfTGLIANaLERLqlsrraesakLDTERE---QLRNSLlAALSHDLRTPLTVL-------------- 687
Cdd:PRK10815 234 REQLDPNPPREL---TSLVRN-LNRL----------LKNERErytKYRTTL-TDLTHSLKTPLAVLqstlrslrsgkqms 298
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 688 FGQAEILMLDlsaegsphtkQVNQIRQQIlstsrlvNNLLDMARIQSGGIQLNLEWQSleeiVGSTLRSLEYALN----R 763
Cdd:PRK10815 299 VEQAEPIMLE----------QISRISQQI-------GYYLHRASMRSEHNLLSRELHS----VAPLLDNLTSALNkvyqR 357
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 764 HPVAVSL---PSDLLLHCDASLLErVFINLLENAIKYTDEQIPlgIKATTEKNQIHIEVWDAGKGIPPEQEQLIFDKFSR 840
Cdd:PRK10815 358 KGVNITLdisPEITFVGEKNDFME-VMGNVLDNACKYCLEFVE--ISARQTDEHLHIVVEDDGPGIPESKRELIFDRGQR 434
|
250 260 270
....*....|....*....|....*....|....*...
gi 37525371 841 ArkESAIPGVGLGLAICRAIIEIHQGKIWASNNEKGGA 878
Cdd:PRK10815 435 A--DTLRPGQGLGLSVAREITEQYEGKISAGDSPLGGA 470
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
779-885 |
2.31e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 89.83 E-value: 2.31e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 779 DASLLERVFINLLENAIKYTDEQIPLGIKATTEKNQIHIEVWDAGKGIPPEQEQLIFDKFSRAR--KESAIPGVGLGLAI 856
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVEssRNRASGGSGLGLAI 80
|
90 100
....*....|....*....|....*....
gi 37525371 857 CRAIIEIHQGKIWASNNEKGGASFHFVLP 885
Cdd:cd16946 81 CHNIALAHGGTISAEHSPLGGLRLVLTLP 109
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
666-887 |
3.57e-21 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 97.29 E-value: 3.57e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 666 EQLRNSLLAALSHDLRTPLTVLFGQAEilML----DLSAEGSPH-TKQVNQIRQQILSTSRLVNnllDMARIQsggIQLN 740
Cdd:PRK09467 226 EDDRTLLMAGVSHDLRTPLTRIRLATE--MMseedGYLAESINKdIEECNAIIEQFIDYLRTGQ---EMPMEM---ADLN 297
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 741 lewQSLEEIVGSTL---RSLEYALNRHPVAVslpsdlllHCDASLLERVFINLLENAIKYTDEQIPlgIKATTEKNQIHI 817
Cdd:PRK09467 298 ---ALLGEVIAAESgyeREIETALQPGPIEV--------PMNPIAIKRALANLVVNAARYGNGWIK--VSSGTEGKRAWF 364
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 37525371 818 EVWDAGKGIPPEQEQLIFDKFSR---ARKESaipGVGLGLAICRAIIEIHQGKIWASNNEKGGASFHFVLPLE 887
Cdd:PRK09467 365 QVEDDGPGIPPEQLKHLFQPFTRgdsARGSS---GTGLGLAIVKRIVDQHNGKVELGNSEEGGLSARAWLPLT 434
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
661-887 |
5.05e-21 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 99.42 E-value: 5.05e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 661 LDTEREQLRNS------LLAALSHDLRTPLTVLFGQAEILmldlSAEGSPHTKQVNQIR------QQILStsrLVNNLLD 728
Cdd:PRK09959 698 LEVERNKAINAtvaksqFLATMSHEIRTPISSIMGFLELL----SGSGLSKEQRVEAISlayatgQSLLG---LIGEILD 770
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 729 MARIQSGGIQLNLEWQSLEEIVGSTLRSLEYALNRHPVAVS----LPSDLLLHCDASLLERVFINLLENAIKYTDEQipl 804
Cdd:PRK09959 771 VDKIESGNYQLQPQWVDIPTLVQNTCHSFGAIAASKSIALScsstFPDHYLVKIDPQAFKQVLSNLLSNALKFTTEG--- 847
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 805 GIKATT-----EKNQ--IHIEVWDAGKGIPPEQEQLIFDKFSRARKESAIPGVGLGLAICRAIIEIHQGKIWASNNEKGG 877
Cdd:PRK09959 848 AVKITTslghiDDNHavIKMTIMDSGSGLSQEEQQQLFKRYSQTSAGRQQTGSGLGLMICKELIKNMQGDLSLESHPGIG 927
|
250
....*....|
gi 37525371 878 ASFHFVLPLE 887
Cdd:PRK09959 928 TTFTITIPVE 937
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
655-889 |
5.23e-21 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 99.21 E-value: 5.23e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 655 RAESAKLDtereQLRNSLLAALSHDLRTPLTVLFGQAEILMLD-LSAEGSPHTKQVNQIRQQILStsrLVNNLLDMARIQ 733
Cdd:PRK11466 434 RAEAEKAS----QAKSAFLAAMSHEIRTPLYGILGTAQLLADNpALNAQRDDLRAITDSGESLLT---ILNDILDYSAIE 506
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 734 SGG--IQLNLEWQSLEEIVGSTLRSLEYALNRHPVAVS------LPSdlLLHCDASLLERVFINLLENAIKYTDEQIpLG 805
Cdd:PRK11466 507 AGGknVSVSDEPFEPRPLLESTLQLMSGRVKGRPIRLAtdiaddLPT--ALMGDPRRIRQVITNLLSNALRFTDEGS-IV 583
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 806 IKATTEKNQIHIEVWDAGKGIPPEQEQLIFDKFSRARKESAipGVGLGLAICRAIIEIHQGKIWASNNEKGGASFHFVLP 885
Cdd:PRK11466 584 LRSRTDGEQWLVEVEDSGCGIDPAKLAEIFQPFVQVSGKRG--GTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLP 661
|
....
gi 37525371 886 LEKP 889
Cdd:PRK11466 662 LRVA 665
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
671-889 |
4.64e-20 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 94.23 E-value: 4.64e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 671 SLLAALSHDLRTPLTVLfgQ-AEILMLDLSAEGsphtKQVNQIRQQILSTSRLVNNLLDMARIQSGGiQLNLEWQSLEEI 749
Cdd:PRK09470 245 RLLSDISHELRTPLTRL--QlATALLRRRQGES----KELERIETEAQRLDSMINDLLVLSRNQQKN-HLERETFKANSL 317
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 750 VGSTLRSLEYA---LNRHPVAVSLPSDLLLHCDASLLERVFINLLENAIKYTDEQIPLGIKAttEKNQIHIEVWDAGKGI 826
Cdd:PRK09470 318 WSEVLEDAKFEaeqMGKSLTVSAPPGPWPINGNPNALASALENIVRNALRYSHTKIEVAFSV--DKDGLTITVDDDGPGV 395
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 37525371 827 PPEQEQLIFDKFSR---AR-KESAipGVGLGLAICRAIIEIHQGKIWASNNEKGGASFHFVLPLEKP 889
Cdd:PRK09470 396 PEEEREQIFRPFYRvdeARdRESG--GTGLGLAIVENAIQQHRGWVKAEDSPLGGLRLTIWLPLYKR 460
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
669-886 |
1.70e-19 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 92.36 E-value: 1.70e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 669 RNSLLAALSHDLRTPLTVLFGQAEilMLDLSAEGSPHTkqvnqIRQQILSTSRLVNNLLDMARIQSGGIQLNLEWQSLEE 748
Cdd:PRK10604 212 KKQLIDGIAHELRTPLVRLRYRLE--MSDNLSAAESQA-----LNRDIGQLEALIEELLTYARLDRPQNELHLSEPDLPA 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 749 IVGSTLRslEYALNRHPVAVSL---PSDLLLHCDASLLERVFINLLENAIKYTDEQIPLGIkaTTEKNQIHIEVWDAGKG 825
Cdd:PRK10604 285 WLSTHLA--DIQAVTPEKTVRLdtpHQGDYGALDMRLMERVLDNLLNNALRYAHSRVRVSL--LLDGNQACLIVEDDGPG 360
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 37525371 826 IPPEQEQLIFDKFSR--ARKESAIPGVGLGLAICRAIIEIHQGKIWASNNEKGGASFHFVLPL 886
Cdd:PRK10604 361 IPPEERERVFEPFVRldPSRDRATGGCGLGLAIVHSIALAMGGSVNCDESELGGARFSFSWPV 423
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
672-886 |
9.09e-19 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 90.56 E-value: 9.09e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 672 LLAALSHDLRTPLTVLFGQaeILMLDLSAEGSPHTKQVnqIRQQILSTSRLVNNLLDMARIQSggiqLNLEWQSLEEIVG 751
Cdd:COG5805 290 LAAGIAHEIRNPLTSIKGF--LQLLQPGIEDKEEYFDI--MLSELDRIESIISEFLALAKPQA----VNKEKENINELIQ 361
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 752 STLRSLEYALNRHPVAVSLPS---DLLLHCDASLLERVFINLLENAIkytdEQIPLG----IKATTEKNQIHIEVWDAGK 824
Cdd:COG5805 362 DVVTLLETEAILHNIQIRLELldeDPFIYCDENQIKQVFINLIKNAI----EAMPNGgtitIHTEEEDNSVIIRVIDEGI 437
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 37525371 825 GIPPEQEQLIFDKFSrARKESaipGVGLGLAICRAIIEIHQGKIWASNNEKGGASFHFVLPL 886
Cdd:COG5805 438 GIPEERLKKLGEPFF-TTKEK---GTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLPL 495
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
754-884 |
3.17e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 81.91 E-value: 3.17e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 754 LRSLEYALNR-HP-----VAVSLPSDLLLHCDASLLERVFINLLENAIKYTDEQIPLGIKATteKNQIHIEVWDAGKGIP 827
Cdd:cd16954 3 LDSLCSALNKvYQrkgvsISLDISPELRFPGERNDLMELLGNLLDNACKWCLEFVEVTARQT--DGGLHLIVDDDGPGVP 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 37525371 828 PEQEQLIFDKFSRArkESAIPGVGLGLAICRAIIEIHQGKIWASNNEKGGASFHFVL 884
Cdd:cd16954 81 ESQRSKIFQRGQRL--DEQRPGQGLGLAIAKEIVEQYGGELSLSDSPLGGARFEVVF 135
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
783-886 |
5.47e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 80.17 E-value: 5.47e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 783 LERVFINLLENAIKYTDEQIPlgIKATTEKNQIHIEVWDAGKGIPPEQEQLIFDKFSR--ARKESAIPGVGLGLAICRAI 860
Cdd:cd16939 1 MARALDNLLRNALRYAHRTVR--IALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRldPSRDRATGGFGLGLAIVHRV 78
|
90 100
....*....|....*....|....*.
gi 37525371 861 IEIHQGKIWASNNEKGGASFHFVLPL 886
Cdd:cd16939 79 ALWHGGHVECDDSELGGACFRLTWPR 104
|
|
| marine_sort_HK |
TIGR03785 |
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is ... |
629-885 |
1.01e-17 |
|
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is paired with an adjacent response regulator (TIGR03787) gene. It co-occurs with a variant sortase enzyme (TIGR03784), usually in the same gene neighborhood, in proteobacterial species most of which are marine, and with an LPXTG motif-containing sortase target conserved protein (TIGR03788). Sortases and LPXTG proteins are far more common in Gram-positive bacteria, where sortase systems mediate attachment to the cell wall or cross-linking of pilin structures. We give this predicted sensor histidine kinase the gene symbol psdS, for Proteobacterial Dedicated Sortase system Sensor histidine kinase.
Pssm-ID: 163497 [Multi-domain] Cd Length: 703 Bit Score: 88.26 E-value: 1.01e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 629 IPEQQRLLQTFTGLIANAlERLQLSRRAES--AKLDTEREQLRNsLLAALSHDLRTPLTVLFGQAEIL-MLDLSAEgspH 705
Cdd:TIGR03785 445 IDSQGRISGAIPASRSRD-EIGDLSRSFAQmvARLRQYTHYLEN-MSSRLSHELRTPVAVVRSSLENLeLQALEQE---K 519
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 706 TKQVNQIRQQILSTSRLVNNLLDMARIQSGGIQLNLEWQSLEEIVGSTLRSLEYALNRHPVAVSLP-SDLLLHCDASLLE 784
Cdd:TIGR03785 520 QKYLERAREGTERLSMILNNMSEATRLEQAIQSAEVEDFDLSEVLSGCMQGYQMTYPPQRFELNIPeTPLVMRGSPELIA 599
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 785 RVFINLLENAIKYTDEQIPLGIKATTEKNQIHIEVWDAGKGIPPEQEQLIFDKFSRARKESA--IPGVGLGLAICRAIIE 862
Cdd:TIGR03785 600 QMLDKLVDNAREFSPEDGLIEVGLSQNKSHALLTVSNEGPPLPEDMGEQLFDSMVSVRDQGAqdQPHLGLGLYIVRLIAD 679
|
250 260
....*....|....*....|....
gi 37525371 863 IHQGKIWASNNEKG-GASFHFVLP 885
Cdd:TIGR03785 680 FHQGRIQAENRQQNdGVVFRISLP 703
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
779-885 |
1.10e-17 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 79.46 E-value: 1.10e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 779 DASLLERVFINLLENAIKYTdeqiPLG--IKATTEK---NQIHIEVWDAGKGIPPEQEQLIFDKFSRARKES--AIPGVG 851
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFT----PDGgrIRCILEKfrlNRFLLTVSDSGPGIPPNLREEIFERFRQGDGSStrAHGGTG 76
|
90 100 110
....*....|....*....|....*....|....
gi 37525371 852 LGLAICRAIIEIHQGKIWASNNEKGGASFHFVLP 885
Cdd:cd16925 77 LGLSIVKEFVELHGGTVTVSDAPGGGALFQVELP 110
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
654-886 |
3.38e-17 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 85.22 E-value: 3.38e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 654 RRAESAKLDTEREQLRNSLLAAL-------SHDLRTPLTVLFGQAEILmldlsAEGSPHTKQVNQIRQQILST----SRL 722
Cdd:PRK10364 215 RRYLRSRQLLQDEMKRKEKLVALghlaagvAHEIRNPLSSIKGLAKYF-----AERAPAGGEAHQLAQVMAKEadrlNRV 289
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 723 VNNLLDMARIQsggiQLNLEWQSLEEIVGSTLRSLEYALNRHPVAVSL-PSDLL--LHCDASLLERVFINLLENAIKYTD 799
Cdd:PRK10364 290 VSELLELVKPT----HLALQAVDLNDLINHSLQLVSQDANSREIQLRFtANDTLpeIQADPDRLTQVLLNLYLNAIQAIG 365
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 800 EQIPLGIKATTEKNQIHIEVWDAGKGIPPEQEQLIFDKFSRARKEsaipGVGLGLAICRAIIEIHQGKIWASNNEKGGAS 879
Cdd:PRK10364 366 QHGVISVTASESGAGVKISVTDSGKGIAADQLEAIFTPYFTTKAE----GTGLGLAVVHNIVEQHGGTIQVASQEGKGAT 441
|
....*..
gi 37525371 880 FHFVLPL 886
Cdd:PRK10364 442 FTLWLPV 448
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
781-886 |
1.48e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 75.92 E-value: 1.48e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 781 SLLERVFINLLENAIKYTDEQIPLGIKATTEKNQIHIEVWDAGKGIPPEQEQLIFDKFSRARKESAipGVGLGLAICRAI 860
Cdd:cd16943 2 SQLNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPVGE--GTGLGLSLSYRI 79
|
90 100
....*....|....*....|....*.
gi 37525371 861 IEIHQGKIWASNNEKGGASFHFVLPL 886
Cdd:cd16943 80 IQKHGGTIRVASVPGGGTRFTIILPI 105
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
663-885 |
2.58e-16 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 82.37 E-value: 2.58e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 663 TEREQL---RNSLLAALSHDLRTPLTVLFGQAEiLMLDLSAEGSPHTKQVNQIRQQILSTSRLVNNLLDMARIQSGGIQL 739
Cdd:PRK11006 195 TQMHQLegaRRNFFANVSHELRTPLTVLQGYLE-MMQDQPLEGALREKALHTMREQTQRMEGLVKQLLTLSKIEAAPTID 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 740 nlewqsLEEIVG--STLRSLEY---AL--NRHPVAVSLPSDLLLHCDASLLERVFINLLENAIKYTDE--QIPLGIKATT 810
Cdd:PRK11006 274 ------LNEKVDvpMMLRVLEReaqTLsqGKHTITFEVDNSLKVFGNEDQLRSAISNLVYNAVNHTPEgtHITVRWQRVP 347
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 37525371 811 EKNQihIEVWDAGKGIPPEQEQLIFDKFSRARK--ESAIPGVGLGLAICRAIIEIHQGKIWASNNEKGGASFHFVLP 885
Cdd:PRK11006 348 QGAE--FSVEDNGPGIAPEHIPRLTERFYRVDKarSRQTGGSGLGLAIVKHALSHHDSRLEIESEVGKGTRFSFVLP 422
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
640-888 |
4.63e-16 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 81.05 E-value: 4.63e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 640 TGLIANALERLQLSRRAEsaKLDTEREQLRNslLAALSHDLRTPLTVLFGqaeilMLDLsaegsphtKQVNQIRQQILST 719
Cdd:COG3290 164 VGAVATFRDRTELERLEE--ELEGVKELAEA--LRAQRHDFRNHLHTISG-----LLQL--------GEYDEALEYIDEI 226
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 720 SRLVNNLLDMARIQSGgiqlnlewqslEEIVGSTLRS-LEYALNRHP-VAVSLPSDL-LLHCDASLLERVFINLLENAI- 795
Cdd:COG3290 227 SEELQELIDSLLSRIG-----------NPVLAALLLGkAARARERGIdLTIDIDSDLpDLPLSDTDLVTILGNLLDNAIe 295
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 796 ---KYTDEQIPLGIKATTEKNQIHIEVWDAGKGIPPEQEQLIFDK--FSRARKESaipgvGLGLAICRAIIEIHQGKIWA 870
Cdd:COG3290 296 aveKLPEEERRVELSIRDDGDELVIEVEDSGPGIPEELLEKIFERgfSTKLGEGR-----GLGLALVKQIVEKYGGTIEV 370
|
250
....*....|....*...
gi 37525371 871 SNNEKGGASFHFVLPLEK 888
Cdd:COG3290 371 ESEEGEGTVFTVRLPKEG 388
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
783-885 |
5.49e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 74.41 E-value: 5.49e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 783 LERVFINLLENAIKYTDEQIPlgIKATTEKNQIHIEVWDAGKGIPPEQEQLIFDKFSRARKESAIPGVGLGLAICRAIIE 862
Cdd:cd16950 1 LKRVLSNLVDNALRYGGGWVE--VSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARGTSGTGLGLAIVQRISD 78
|
90 100
....*....|....*....|...
gi 37525371 863 IHQGKIWASNNEKGGASFHFVLP 885
Cdd:cd16950 79 AHGGSLTLANRAGGGLCARIELP 101
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
783-876 |
6.96e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 73.96 E-value: 6.96e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 783 LERVFINLLENAIKYTDEQIPLGIKATTEKNQIHIEVWDAGKGIPPEQEQLIFDKFSRARKESAIPGVGLGLAICRAIIE 862
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSRNTEGAGLGLSIAKAIIE 80
|
90
....*....|....
gi 37525371 863 IHQGKIWASNNEKG 876
Cdd:cd16923 81 LHGGSASAEYDDNH 94
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
674-885 |
1.52e-15 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 80.20 E-value: 1.52e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 674 AALSHDLRTPLTVLFGQAEILmldLSAEGSPhtkqvNQIRQQILST-------SRLVNNLLDMAriQSGGIQLNLEWQSL 746
Cdd:PRK09835 267 ADIAHEIRTPITNLITQTEIA---LSQSRSQ-----KELEDVLYSNleeltrmAKMVSDMLFLA--QADNNQLIPEKKML 336
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 747 EeIVGSTLRSLEY----ALNRHpVAVSLPSDlllHC----DASLLERVFINLLENAIKYTDEQIPLGIKATTEKNQIHIE 818
Cdd:PRK09835 337 D-LADEVGKVFDFfeawAEERG-VELRFVGD---PCqvagDPLMLRRAISNLLSNALRYTPAGEAITVRCQEVDHQVQLV 411
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 37525371 819 VWDAGKGIPPEQEQLIFDKF-----SRARKESaipGVGLGLAICRAIIEIHQGKIWASNNEKgGASFHFVLP 885
Cdd:PRK09835 412 VENPGTPIAPEHLPRLFDRFyrvdpSRQRKGE---GSGIGLAIVKSIVVAHKGTVAVTSDAR-GTRFVISLP 479
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
678-877 |
2.04e-15 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 79.69 E-value: 2.04e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 678 HDLRTPLTVLFGQAEILMLDLSAEGSPHtKQVNQIRQQILSTSRLVNNLLDMARIQSGGIQLNLEWQSLEEIVGSTLRS- 756
Cdd:PRK10337 246 HELRSPLAALKVQTEVAQLSDDDPQARK-KALLQLHAGIDRATRLVDQLLTLSRLDSLDNLQDVAEIPLEDLLQSAVMDi 324
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 757 ----------LEYALNRHPVAVSLPSDLLlhcdaSLLERvfiNLLENAIKYTdeqiPLGIKATTEKNQIHIEVWDAGKGI 826
Cdd:PRK10337 325 yhtaqqagidVRLTLNAHPVIRTGQPLLL-----SLLVR---NLLDNAIRYS----PQGSVVDVTLNARNFTVRDNGPGV 392
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 37525371 827 PPEQEQLIFDKFSRARKESAiPGVGLGLAICRAIIEIHQGKIWASNNEKGG 877
Cdd:PRK10337 393 TPEALARIGERFYRPPGQEA-TGSGLGLSIVRRIAKLHGMNVSFGNAPEGG 442
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
777-877 |
3.96e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 72.05 E-value: 3.96e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 777 HCDASLLERVFINLLENAIKYT--DEQIPLGIKATTEKNqihIEVWDAGKGIPPEQEQLIFDKFSRARKESAiPGVGLGL 854
Cdd:cd16940 8 QGDALLLFLLLRNLVDNAVRYSpqGSRVEIKLSADDGAV---IRVEDNGPGIDEEELEALFERFYRSDGQNY-GGSGLGL 83
|
90 100
....*....|....*....|...
gi 37525371 855 AICRAIIEIHQGKIWASNNEKGG 877
Cdd:cd16940 84 SIVKRIVELHGGQIFLGNAQGGG 106
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
603-885 |
5.32e-14 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 74.62 E-value: 5.32e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 603 QLQPIATPSQTLAVLAIEPSyLRQLLIpeqqrllqtftglianaleRLQLSrraesakLDTEReqlrnsLLAA-LSHDLR 681
Cdd:PRK10755 103 NLTPIAIHSSTLEIEAVTSA-LNQLVS-------------------RLTST-------LDQER------LFTAdVAHELR 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 682 TPLtvlfgqAEI-LMLDLSAEGspHTKQVNQIRQQILSTSRLVNNLLDMARIQ---SGGIQLNLEWqsLEEIV---GSTL 754
Cdd:PRK10755 150 TPL------AGIrLHLELLEKQ--HHIDVAPLIARLDQMMHTVEQLLQLARAGqsfSSGHYQTVKL--LEDVIlpsQDEL 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 755 RSLEYALNRHPVAVSLPSDLLLHCDASLLERVFINLLENAIKYTDEQIPLGIKATTEKNQIHIEVWDAGKGIPPEQEQLI 834
Cdd:PRK10755 220 SEMLEQRQQTLLLPESAADITVQGDATLLRLLLRNLVENAHRYSPEGSTITIKLSQEDGGAVLAVEDEGPGIDESKCGEL 299
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 37525371 835 FDKFSRArkESAIPGVGLGLAICRAIIEIHQGKIWASN-NEKGGASFHFVLP 885
Cdd:PRK10755 300 SKAFVRM--DSRYGGIGLGLSIVSRITQLHHGQFFLQNrQERSGTRAWVWLP 349
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
783-885 |
7.22e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 68.37 E-value: 7.22e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 783 LERVFINLLENAIKYT-DEQIPLGIKATTEKNQIHIEVWDAGKGIPPEQEQLIFDKFSRARKESAIPGV--GLGLAICRA 859
Cdd:cd16953 1 LGQVLRNLIGNAISFSpPDTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERPANEAFGQhsGLGLSISRQ 80
|
90 100 110
....*....|....*....|....*....|
gi 37525371 860 IIEIHQGKIWASNNEKG----GASFHFVLP 885
Cdd:cd16953 81 IIEAHGGISVAENHNQPgqviGARFTVQLP 110
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
779-880 |
7.95e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 68.26 E-value: 7.95e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 779 DASLLERVFINLLENAIKYTDEQIPLGIKATTEKNQIHIEVWDAGKGIPPEQEQLIFDKF-SRARKESAIPGVGLGLAIC 857
Cdd:cd16945 1 DPFLLRQAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFySLPRPHSGQKSTGLGLAFV 80
|
90 100
....*....|....*....|...
gi 37525371 858 RAIIEIHQGKIWASNNEKGGASF 880
Cdd:cd16945 81 QEVAQLHGGRITLRNRPDGVLAF 103
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
663-897 |
8.76e-14 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 75.36 E-value: 8.76e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 663 TEREQLRNSL----------LAALSHDLRTPLTVLFGQAEILM-LDLSAEgspHTKQVNQIRQQILSTSRLVNNLLDMAR 731
Cdd:PRK11091 267 TERKRYQDALekasrdkttfISTISHELRTPLNGIVGLSRILLdTELTAE---QRKYLKTIHVSAITLGNIFNDIIDMDK 343
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 732 IQSGGIQLNLEWQSLEEIVG-----STL----RSLEYALNRHPvavSLPSDLLLhcDASLLERVFINLLENAIKYTDE-Q 801
Cdd:PRK11091 344 MERRKLQLDNQPIDFTDFLAdlenlSGLqaeqKGLRFDLEPLL---PLPHKVIT--DGTRLRQILWNLISNAVKFTQQgG 418
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 802 IPLGIKATtEKNQIHIEVWDAGKGIPPEQEQLIFDKF----SRARKESAIpGVGLGLAICRAIIEIHQGKIWASNNEKGG 877
Cdd:PRK11091 419 VTVRVRYE-EGDMLTFEVEDSGIGIPEDELDKIFAMYyqvkDSHGGKPAT-GTGIGLAVSKRLAQAMGGDITVTSEEGKG 496
|
250 260
....*....|....*....|
gi 37525371 878 ASFHFVLPLEKPPEIITEEM 897
Cdd:PRK11091 497 SCFTLTIHAPAVAEEVEDAF 516
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
779-878 |
5.99e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 65.95 E-value: 5.99e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 779 DASLLERVFINLLENAIKYTDEQIPLGIKATTEKNQIHIEVWDAGKGIPPEQEQLIFDKFSRARKESAIPG-VGLGLAIC 857
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRSGGhYGMGLYIA 80
|
90 100
....*....|....*....|.
gi 37525371 858 RAIIEIHQGKIWASNNEKGGA 878
Cdd:cd16975 81 KNLVEKHGGSLIIENSQKGGA 101
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
766-875 |
1.66e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 65.23 E-value: 1.66e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 766 VAVSLP-SDLLLHCDASLLERVFINLLENAIKYTDEQIPLGIKATTEKNQIHIEVWDAGKGIPPEQEQLIFDKFSRA--R 842
Cdd:cd16947 3 VEINIPdRPIYANANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLedS 82
|
90 100 110
....*....|....*....|....*....|....*
gi 37525371 843 KESAIPGVGLGLAICRAIIEIHQGKIWASN--NEK 875
Cdd:cd16947 83 RNSAKQGNGLGLTITKRLAESMGGSIYVNSkpYEK 117
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
673-896 |
1.13e-11 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 68.72 E-value: 1.13e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 673 LAALSHDLRTPLTVLFGQAEILMldlsaEGSPHTKQVNQIRQQILSTSRL---VNNLLDMARIQSGGIQL-NLEWQ---S 745
Cdd:PRK11107 297 LANMSHELRTPLNGVIGFTRQTL-----KTPLTPTQRDYLQTIERSANNLlaiINDILDFSKLEAGKLVLeNIPFSlreT 371
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 746 LEEIVgsTLRS-------LEYALNRHPvavSLPSDLLlhCDASLLERVFINLLENAIKYTDE---QIPLGIKA-TTEKNQ 814
Cdd:PRK11107 372 LDEVV--TLLAhsahekgLELTLNIDP---DVPDNVI--GDPLRLQQIITNLVGNAIKFTESgniDILVELRAlSNTKVQ 444
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 815 IHIEVWDAGKGIPPEQEQLIFDKFSRArkESAIP----GVGLGLAICRAIIEIHQGKIWASNNEKGGASFHFVLPLEKPP 890
Cdd:PRK11107 445 LEVQIRDTGIGISERQQSQLFQAFRQA--DASISrrhgGTGLGLVITQKLVNEMGGDISFHSQPNRGSTFWFHLPLDLNP 522
|
....*.
gi 37525371 891 EIITEE 896
Cdd:PRK11107 523 NPIIDG 528
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
669-735 |
1.39e-11 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 60.66 E-value: 1.39e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 37525371 669 RNSLLAALSHDLRTPLTVLFGQAEILmldLSAEGSPHTKQ-VNQIRQQILSTSRLVNNLLDMARIQSG 735
Cdd:smart00388 2 KREFLANLSHELRTPLTAIRGYLELL---LDTELSEEQREyLETILREAERLLRLINDLLDLSRIEAG 66
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
669-735 |
1.74e-11 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 60.30 E-value: 1.74e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 37525371 669 RNSLLAALSHDLRTPLTVLFGQAEILMLDLSAEgsPHTKQVNQIRQQILSTSRLVNNLLDMARIQSG 735
Cdd:pfam00512 2 KSEFLANLSHELRTPLTAIRGYLELLRDEKLDE--EQREYLETILRSAERLLRLINDLLDLSRIEAG 66
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
666-731 |
2.02e-11 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 59.92 E-value: 2.02e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 37525371 666 EQLRNSLLAALSHDLRTPLTVLFGQAEiLMLDLSAEGSPHTKQVNQIRQQILSTSRLVNNLLDMAR 731
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALE-LLEEELLDDEEQREYLERIREEAERLLRLINDLLDLSR 65
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
634-877 |
2.20e-11 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 67.40 E-value: 2.20e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 634 RLLQTFTGLI----ANALERLQLSRRAESAKLDTEREQLRNSLLAA-------LSHDLRTPLTVLfgQAEILMLDLSAEG 702
Cdd:COG4192 387 RLLRVFRDQAiektQELETEIEERKRIEKNLRQTQDELIQAAKMAVvgqtmtsLAHELNQPLNAM--SMYLFSAKKALEQ 464
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 703 SPHTK---QVNQIRQQILSTSRLVNNLLDMARIQSGGIQLnlewQSLEEIVGSTLRSLEYALNRHPVAVSLPSDLLLHCD 779
Cdd:COG4192 465 ENYAQlptSLDKIEGLIERMDKIIKSLRQFSRKSDTPLQP----VDLRQVIEQAWELVESRAKPQQITLHIPDDLMVQGD 540
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 780 ASLLERVFINLLENAIKYTDEQIPLGIKATTEKNQIHIEVWDAGKGIPpeqeqlIFDKFSRARKESAIPGVGLGLAICRA 859
Cdd:COG4192 541 QVLLEQVLVNLLVNALDAVATQPQISVDLLSNAENLRVAISDNGNGWP------LVDKLFTPFTTTKEVGLGLGLSICRS 614
|
250
....*....|....*....
gi 37525371 860 IIEIHQGKIW-ASNNEKGG 877
Cdd:COG4192 615 IMQQFGGDLYlASTLERGA 633
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
673-886 |
2.81e-11 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 67.69 E-value: 2.81e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 673 LAALSHDLRTPLTVLFGQAEILmldlsaegspHTKQVNQIRQQILST----SRL----VNNLLDMARIQSGgiQLNLEWQ 744
Cdd:PRK10841 451 LATVSHELRTPLYGIIGNLDLL----------QTKELPKGVDRLVTAmnnsSSLllkiISDILDFSKIESE--QLKIEPR 518
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 745 --SLEEIVGstlrsleyalnrHPVAVSLP----SDLLLHC------------DASLLERVFINLLENAIKYTDeqipLG- 805
Cdd:PRK10841 519 efSPREVIN------------HITANYLPlvvkKRLGLYCfiepdvpvalngDPMRLQQVISNLLSNAIKFTD----TGc 582
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 806 --IKATTEKNQIHIEVWDAGKGIPP-EQEQLiFDKFSRA--RKESAIPGVGLGLAICRAIIEIHQGKIwASNNEKG-GAS 879
Cdd:PRK10841 583 ivLHVRVDGDYLSFRVRDTGVGIPAkEVVRL-FDPFFQVgtGVQRNFQGTGLGLAICEKLINMMDGDI-SVDSEPGmGSQ 660
|
....*..
gi 37525371 880 FHFVLPL 886
Cdd:PRK10841 661 FTIRIPL 667
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
783-885 |
4.07e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 60.68 E-value: 4.07e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 783 LERVFINLLENAIKYTDEQIPLGIKATTEKNQIHIEVWDAGKGIPPEQEQLIFDKFSRARKESA--IPGVGLGLAICRAI 860
Cdd:cd16952 1 LRSAFSNLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCrnTGGTGLGLAIVKHV 80
|
90 100
....*....|....*....|....*
gi 37525371 861 IEIHQGKIWASNNEKGGASFHFVLP 885
Cdd:cd16952 81 MSRHDARLLIASELGKGSRFTCLFP 105
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
779-885 |
5.11e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 60.24 E-value: 5.11e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 779 DASLLERVFINLLENAIKYTdEQIPLG-----IKATTEK-NQIHIEVWDAGKGIPPEQEQLIFDKFSRARKEsaipGVGL 852
Cdd:cd16944 1 DTTQISQVLTNILKNAAEAI-EGRPSDvgevrIRVEADQdGRIVLIVCDNGKGFPREMRHRATEPYVTTRPK----GTGL 75
|
90 100 110
....*....|....*....|....*....|...
gi 37525371 853 GLAICRAIIEIHQGKIWASNNEKGGASFHFVLP 885
Cdd:cd16944 76 GLAIVKKIMEEHGGRISLSNREAGGACIRIILP 108
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
783-884 |
2.44e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 58.24 E-value: 2.44e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 783 LERVFINLLENAI-KYTDEQIP-LGIKATTEKNQIHIEVWDAGKGIPPEQEQLIFDKFSRARKESAipGVGLGLAICRAI 860
Cdd:cd16976 1 IQQVLMNLLQNALdAMGKVENPrIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTKPVGK--GTGLGLSISYGI 78
|
90 100
....*....|....*....|....
gi 37525371 861 IEIHQGKIWASNNEKGGASFHFVL 884
Cdd:cd16976 79 VEEHGGRLSVANEEGAGARFTFDL 102
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
789-885 |
2.52e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 58.07 E-value: 2.52e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 789 NLLENAIKYT-DEQIPLG---IKATTEKNQIHIEVWDAGKGIPPEQEQLIFDK-FS-RARKESaipgvGLGLAICRAIIE 862
Cdd:cd16915 7 NLIDNALDALaATGAPNKqveVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERgVStKGQGER-----GIGLALVRQSVE 81
|
90 100
....*....|....*....|...
gi 37525371 863 IHQGKIWASNNEKGGASFHFVLP 885
Cdd:cd16915 82 RLGGSITVESEPGGGTTFSIRIP 104
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
779-885 |
7.32e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 54.21 E-value: 7.32e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 779 DASLLERVFINLLENAIKYTDEQIPLGIKATTEKNQIHIEVWDAGKGIPPEQEQLIFDKF---SRARKESAIPGVGLGLA 855
Cdd:cd16948 2 DAKWLSFIIGQIVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGftgENGRNFQESTGMGLYLV 81
|
90 100 110
....*....|....*....|....*....|
gi 37525371 856 icRAIIEIHQGKIWASNNEKGGASFHFVLP 885
Cdd:cd16948 82 --KKLCDKLGHKIDVESEVGEGTTFTITFP 109
|
|
| GAF_3 |
pfam13492 |
GAF domain; |
531-649 |
7.89e-09 |
|
GAF domain;
Pssm-ID: 433253 [Multi-domain] Cd Length: 129 Bit Score: 54.68 E-value: 7.89e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 531 NEEDIARTSYHFLTNGFQAKTG-LFLPNDDGNLYQLTTNNGGH------MLIDDAIAKWSFDKNLPA----GAGTDTLPS 599
Cdd:pfam13492 1 SLDEILEALLKLLVRLLGAERAaVYLLDEDGNKLQVAAGYDGEpdpsesLDADSPLARRALSSGEPIsglgSAGEDGLPD 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 37525371 600 VPYQLQPIATPSQTLAVLAIEPSYLRQLLiPEQQRLLQTFTGLIANALER 649
Cdd:pfam13492 81 GPALVVPLVAGRRVIGVLALASSKPRAFD-AEDLRLLESLAAQIATAIEN 129
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
611-891 |
1.06e-08 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 58.92 E-value: 1.06e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 611 SQTLAVLAIEpsYLRQLLIP--EQQRLLQTFTGLIANALE--RLQLSRRAESAKLD-TEREQLRNSLLAALSHDLRTPLT 685
Cdd:PRK13837 389 DRIVALLGLG--RQRYGLRPpaGELQLLELALDCLAHAIErrRLETERDALERRLEhARRLEAVGTLASGIAHNFNNILG 466
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 686 VLFGQAEIlMLDLSAEGSPHTKQVNQIRQQILSTSRLVNNLLDMARIQSGgiqlNLEWQSLEEIVGSTLRSLEYALNRHp 765
Cdd:PRK13837 467 AILGYAEM-ALNKLARHSRAARYIDEIISAGARARLIIDQILAFGRKGER----NTKPFDLSELVTEIAPLLRVSLPPG- 540
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 766 VAVSL---PSDLLLHCDASLLERVFINLLENAIKYTDE--QIPLGIKA---TTEKNQIH----------IEVWDAGKGIP 827
Cdd:PRK13837 541 VELDFdqdQEPAVVEGNPAELQQVLMNLCSNAAQAMDGagRVDISLSRaklRAPKVLSHgvlppgryvlLRVSDTGAGID 620
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 37525371 828 PEQEQLIFDKF--SRARkesaipGVGLGLAICRAIIEIHQGKIWASNNEKGGASFHFVLPLEKPPE 891
Cdd:PRK13837 621 EAVLPHIFEPFftTRAG------GTGLGLATVHGIVSAHAGYIDVQSTVGRGTRFDVYLPPSSKVP 680
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
783-868 |
2.46e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 52.79 E-value: 2.46e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 783 LERVFINLLENAIK-------------YTDEQIPLGikATTEKNQIHIEVWDAGKGIPPEQEQLIFDKFSRARKEsaipG 849
Cdd:cd16918 1 LIQVFLNLVRNAAQalagsggeiilrtRTQRQVTLG--HPRHRLALRVSVIDNGPGIPPDLQDTIFYPMVSGREN----G 74
|
90
....*....|....*....
gi 37525371 850 VGLGLAICRAIIEIHQGKI 868
Cdd:cd16918 75 TGLGLAIAQNIVSQHGGVI 93
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
790-888 |
1.62e-07 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 54.64 E-value: 1.62e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 790 LLENAIKY----TDEQIPLGIKATTEKNQIHIEVWDAGKGIPPEQEQLIFDKFSRARKESaipgvGLGLAICRAIIEIHQ 865
Cdd:COG2972 344 LVENAIEHgiepKEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEELSSKGEGR-----GIGLRNVRERLKLYY 418
|
90 100
....*....|....*....|....*.
gi 37525371 866 GK---IWASNNEKGGASFHFVLPLEK 888
Cdd:COG2972 419 GEeygLEIESEPGEGTTVTIRIPLEE 444
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
657-886 |
9.10e-07 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 52.01 E-value: 9.10e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 657 ESAKLDTER----EQLRNS-------LLAALSHDLRTPLTVLFGQAEILMLDLSaegSPHTKQVNQIrqqILSTSRLVNN 725
Cdd:PRK11073 107 EMAPMDNQRrlsqEQLQHAqqvaardLVRGLAHEIKNPLGGLRGAAQLLSKALP---DPALTEYTKV---IIEQADRLRN 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 726 LLDmaRI---QSGGIQlnlEWQSLEEIVG--STLRSLEYALNrhpVAV------SLPSdlLLHcDASLLERVFINLLENA 794
Cdd:PRK11073 181 LVD--RLlgpQRPGTH---VTESIHKVAErvVQLVSLELPDN---VRLirdydpSLPE--LAH-DPDQIEQVLLNIVRNA 249
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 795 IKYTDEQ---IPLGIKaTTEKNQIH---------IEVWDAGKGIPPEQEQLIFDKFSRARKEsaipGVGLGLAICRAIIE 862
Cdd:PRK11073 250 LQALGPEggtITLRTR-TAFQLTLHgeryrlaarIDIEDNGPGIPPHLQDTLFYPMVSGREG----GTGLGLSIARNLID 324
|
250 260
....*....|....*....|....*...
gi 37525371 863 IHQGKI----WASNNEkggasFHFVLPL 886
Cdd:PRK11073 325 QHSGKIeftsWPGHTE-----FSVYLPI 347
|
|
| PRK10618 |
PRK10618 |
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional |
649-841 |
8.87e-05 |
|
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 46.46 E-value: 8.87e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 649 RLQLSRRaESAKldteREQLRNSLLAALSHDLRTPLTVLFGQAEILMLDLSAEGspHTKQVNQIRQQILSTSRLVNNLLD 728
Cdd:PRK10618 435 KLQQAQR-EYEK----NQQARKAFLQNIGDELKQPLQSLAQLAAQLRQTSDEEQ--QQPELDQLAEQSDVLVRLVDNIQL 507
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 729 MARIQSGGIQLNLEWQSLEEIVGSTLRSLEYALNRHP----VAVSLPSDLLLHCDASLLERVFINLLENAIKYTD-EQIP 803
Cdd:PRK10618 508 LNMLETQDWKPEQELFSLQDLIDEVLPEVLPAIKRKGlqllIHNHLKAEQLRIGDRDALRKILLLLLNYAITTTAyGKIT 587
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 37525371 804 LGIKATTE-KNQIHIEVWDAGKGIPP-EQEQLIF--------DKFSRA 841
Cdd:PRK10618 588 LEVDQDESsPDRLTIRILDTGAGVSIkELDNLHFpflnqtqgDRYGKA 635
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
790-860 |
1.16e-04 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 42.59 E-value: 1.16e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 37525371 790 LLENAIKYTDEQIPLG---IKATTEKNQIHIEVWDAGKGIPPEQeqlifdkfsRARKESAIPGVGLGLAICRAI 860
Cdd:COG2172 42 AVTNAVRHAYGGDPDGpveVELELDPDGLEIEVRDEGPGFDPED---------LPDPYSTLAEGGRGLFLIRRL 106
|
|
| LytS |
COG3275 |
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms]; |
787-889 |
1.33e-04 |
|
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];
Pssm-ID: 442506 [Multi-domain] Cd Length: 352 Bit Score: 45.24 E-value: 1.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 787 FINLLENAIKY----TDEQIPLGIKATTEKNQIHIEVWDAGKGIPPEQEQlifdkfsrarkesaiPGVGLGLAICRAIIE 862
Cdd:COG3275 258 LQPLVENAIKHgissKEGGGTISISIEVEGDRLVIEVENNGVGIQPKKKK---------------KGSGIGLKNVRERLE 322
|
90 100 110
....*....|....*....|....*....|
gi 37525371 863 IHQGKIWA---SNNEKGGASFHFVLPLEKP 889
Cdd:COG3275 323 LLYGDKYSleiESTDGGGTKVTLKIPLKKE 352
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
635-889 |
2.37e-04 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 43.84 E-value: 2.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 635 LLQTFTGLIANALERLQLSRRAESAKLDTEREQLRNSLLAALsHDlrTPLTVLFG---QAEILMLDLSAEGSPHTKQVNQ 711
Cdd:COG4585 20 LLLALVLLRARRAERAAELERELAARAEEAREEERRRIAREL-HD--GVGQSLSAiklQLEAARRLLDADPEAAREELEE 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 712 IRQQILSTSRLVNNLLDMARiQSGGIQLNLEwQSLEEIVGSTLRS--LEYALNRHPVAVSLPSDLLLHcdaslLERVFIN 789
Cdd:COG4585 97 IRELAREALAELRRLVRGLR-PPALDDLGLA-AALEELAERLLRAagIRVELDVDGDPDRLPPEVELA-----LYRIVQE 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 790 LLENAIKYTDEQiPLGIKATTEKNQIHIEVWDAGKGIPPEqeqlifdkfsrarkesAIPGVGLGLAICRAIIEIHQGKIW 869
Cdd:COG4585 170 ALTNALKHAGAT-RVTVTLEVDDGELTLTVRDDGVGFDPE----------------AAPGGGLGLRGMRERAEALGGTLT 232
|
250 260
....*....|....*....|
gi 37525371 870 ASNNEKGGASFHFVLPLEKP 889
Cdd:COG4585 233 IGSAPGGGTRVRATLPLAAA 252
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
789-868 |
1.61e-03 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 42.21 E-value: 1.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 789 NLLENAIKYTDEQIPLGIKATT--EKNQIHIEVWDAGKGIPPEQEQLIFDK-FSrarkeSAIPGVGLGLAICRAIIEIHQ 865
Cdd:PRK11086 440 NLIENALEAVGGEEGGEISVSLhyRNGWLHCEVSDDGPGIAPDEIDAIFDKgYS-----TKGSNRGVGLYLVKQSVENLG 514
|
...
gi 37525371 866 GKI 868
Cdd:PRK11086 515 GSI 517
|
|
| HATPase_PDK-like |
cd16929 |
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ... |
781-868 |
1.96e-03 |
|
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.
Pssm-ID: 340406 [Multi-domain] Cd Length: 169 Bit Score: 40.02 E-value: 1.96e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 781 SLLERVFINLLENAIKYT-------DEQIPlGIKATTEKNQIH--IEVWDAGKGIPPEQEQLIFD-KFSRARKESAIP-- 848
Cdd:cd16929 42 SHLYYILFELLKNAMRATveshgddSDDLP-PIKVTVAKGDEDltIKISDRGGGIPREDLARLFSyMYSTAPQPSLDDfs 120
|
90 100 110
....*....|....*....|....*....|..
gi 37525371 849 ------------GVGLGLAICRAIIEIHQGKI 868
Cdd:cd16929 121 dlisgtqpsplaGFGYGLPMSRLYAEYFGGDL 152
|
|
| HATPase_RsbW-like |
cd16936 |
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ... |
790-860 |
2.41e-03 |
|
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.
Pssm-ID: 340413 [Multi-domain] Cd Length: 91 Bit Score: 38.02 E-value: 2.41e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 37525371 790 LLENAIKYT---DEQIPLGIKATTEKNQIHIEVWDAGKGIPPEQeqlifdkfsRARKESAIPGVGLGLAICRAI 860
Cdd:cd16936 8 AVTNAVRHAyrhDGPGPVRLELDLDPDRLRVEVTDSGPGFDPLR---------PADPDAGLREGGRGLALIRAL 72
|
|
| HATPase_LytS-like |
cd16957 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
790-885 |
2.83e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.
Pssm-ID: 340433 [Multi-domain] Cd Length: 106 Bit Score: 38.18 E-value: 2.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 790 LLENAIKY------TDEQIPLGIKATTEKnqIHIEVWDAGKGIPPEQEQLIfDKFSRARKEsaipGVGLGLA-ICRAIIE 862
Cdd:cd16957 9 LVENAIRHafpkrkENNEVRVVVKKDQHK--VHVSVSDNGQGIPEERLDLL-GKTTVTSEK----GTGTALEnLNRRLIG 81
|
90 100
....*....|....*....|....*
gi 37525371 863 IH--QGKIWASNNEKGGASFHFVLP 885
Cdd:cd16957 82 LFgsEACLHIESEVHGGTEVWFVIP 106
|
|
|