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The query sequence NP_928715.1 may be preliminary or obsolete. For more information, check Entrez.
Conserved domains on  [gi|37525371|ref|NP_928715.1|]
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sensor protein KdpD [Photorhabdus luminescens subsp. laumondii TTO1]

Protein Classification

sensor histidine kinase( domain architecture ID 11484744)

sensor histidine kinase, part of a two-component regulatory system, functions as a protein kinase that phosphorylates a target protein in response to various signals

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PRK10490 PRK10490
sensor protein KdpD; Provisional
2-897 0e+00

sensor protein KdpD; Provisional


:

Pssm-ID: 236701 [Multi-domain]  Cd Length: 895  Bit Score: 1874.72  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371    2 DQHEPQRPDPDELLTLVNEKQRGKLKIFFGACAGVGKTYAMLQEAQRLRAQGLDVVIGVVETHERQGTAALLDGLPQLPL 81
Cdd:PRK10490   1 MNNEPLRPDPDRLLEQTAEPHRGKLKIFFGACAGVGKTYAMLQEAQRLRAQGLDVLVGVVETHGRKETAALLEGLTVLPP 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371   82 KQIYYRRRKISVFDLDAAIARHPAIILMDELAFSNPHTNRHPKRWQDVEELLEAGIDVLTTINVQHLESLNDVVGDITGI 161
Cdd:PRK10490  81 KRIHHRGRHISEFDLDAALARRPALILMDELAHSNAPGSRHPKRWQDVEELLEAGIDVFTTVNVQHLESLNDVVGGVTGI 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  162 RVRETIPDHIFDQANEIVLVDLPPDDLRQRLNEGKVYIPSQAERAIEHFFRKGNLIALRELALRRTADRVDDQMRAFRDT 241
Cdd:PRK10490 161 QVRETVPDPFFDAADEVVLVDLPPDDLRQRLNEGKVYIAGQAERAIEHFFRKGNLIALRELALRRTADRVDDQMRAWRDH 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  242 QGHEPVWHTRDNLLLCIGNSSGNEKLIRTAARLAARLGCIWHAIYVETPKLYQLPEGKRRSILKALRLAHELGAETATLS 321
Cdd:PRK10490 241 QGEEKVWHTRDAILLCIGHNTGSEKLVRTAARLAARLGSVWHAVYVETPRLHRLPEKKRRAILSALRLAQELGAETATLS 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  322 DPNKEKAVLRYAREHNLGKILIGRRCTSKqklfgWQWRSGFADRLGKLGPDLDLVIVALEER--SHWDKEQDNRSVSEKW 399
Cdd:PRK10490 321 DPAEEKAVLRYAREHNLGKIIIGRRASRR-----WWRRESFADRLARLGPDLDLVIVALDEPpaRAIAKAPDSRPFKEKW 395
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  400 RVQIQGCLIAIALCTLITLFSRTFLLTLDKANLVTLYLLGVVVIALFYGRRPSIFAAFINVISFDIFFVQPHWSLAVTDM 479
Cdd:PRK10490 396 RVQIQGCLVAIALCALITLIAMQWLPAFDAANLVMLYLLGVVVVALFYGRWPSVVATVINVASFDLFFVAPRGTLAVSDV 475
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  480 QYLLTFSVMLIVGVVVGNLTAGMRYQARIARYREQRTRNLYEMTRELSRALNEEDIARTSYHFLTNGFQAKTGLFLPNDD 559
Cdd:PRK10490 476 QYLLTFAVMLTVGLVIGNLTAGVRYQARVARYREQRTRHLYEMSKALAVGLSPEDIAATSEHFLASTFQARSQLLLPDDN 555
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  560 GNLYQLTTNNgGHMLIDDAIAKWSFDKNLPAGAGTDTLPSVPYQLQPIATPSQTLAVLAIEPSYLRQLLIPEQQRLLQTF 639
Cdd:PRK10490 556 GKLQPLTHDQ-GMTPWDDAIARWSFDKGQPAGAGTDTLPGVPYQILPLKSAQKTYGLLAVEPGNLRQLMIPEQQRLLETF 634
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  640 TGLIANALERLQLSRRAESAKLDTEREQLRNSLLAALSHDLRTPLTVLFGQAEILMLDLSAEGSPHTKQVNQIRQQILST 719
Cdd:PRK10490 635 TLLIANALERLTLTASEEQARLASEREQLRNALLAALSHDLRTPLTVLFGQAEILTLDLASEGSPHARQASEIRQQVLNT 714
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  720 SRLVNNLLDMARIQSGGIQLNLEWQSLEEIVGSTLRSLEYALNRHPVAVSLPSDL-LLHCDASLLERVFINLLENAIKYT 798
Cdd:PRK10490 715 TRLVNNLLDMARIQSGGFNLRKEWLTLEEVVGSALQMLEPGLSGHPINLSLPEPLtLIHVDGPLFERVLINLLENAVKYA 794
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  799 DEQIPLGIKATTEKNQIHIEVWDAGKGIPPEQEQLIFDKFSRARKESAIPGVGLGLAICRAIIEIHQGKIWASNNEKGGA 878
Cdd:PRK10490 795 GAQAEIGIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDKFARGNKESAIPGVGLGLAICRAIVEVHGGTIWAENRPEGGA 874
                        890       900
                 ....*....|....*....|.
gi 37525371  879 SFHFVLPLEKPPEI--ITEEM 897
Cdd:PRK10490 875 CFRVTLPLETPPELeeFHEDM 895
 
Name Accession Description Interval E-value
PRK10490 PRK10490
sensor protein KdpD; Provisional
2-897 0e+00

sensor protein KdpD; Provisional


Pssm-ID: 236701 [Multi-domain]  Cd Length: 895  Bit Score: 1874.72  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371    2 DQHEPQRPDPDELLTLVNEKQRGKLKIFFGACAGVGKTYAMLQEAQRLRAQGLDVVIGVVETHERQGTAALLDGLPQLPL 81
Cdd:PRK10490   1 MNNEPLRPDPDRLLEQTAEPHRGKLKIFFGACAGVGKTYAMLQEAQRLRAQGLDVLVGVVETHGRKETAALLEGLTVLPP 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371   82 KQIYYRRRKISVFDLDAAIARHPAIILMDELAFSNPHTNRHPKRWQDVEELLEAGIDVLTTINVQHLESLNDVVGDITGI 161
Cdd:PRK10490  81 KRIHHRGRHISEFDLDAALARRPALILMDELAHSNAPGSRHPKRWQDVEELLEAGIDVFTTVNVQHLESLNDVVGGVTGI 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  162 RVRETIPDHIFDQANEIVLVDLPPDDLRQRLNEGKVYIPSQAERAIEHFFRKGNLIALRELALRRTADRVDDQMRAFRDT 241
Cdd:PRK10490 161 QVRETVPDPFFDAADEVVLVDLPPDDLRQRLNEGKVYIAGQAERAIEHFFRKGNLIALRELALRRTADRVDDQMRAWRDH 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  242 QGHEPVWHTRDNLLLCIGNSSGNEKLIRTAARLAARLGCIWHAIYVETPKLYQLPEGKRRSILKALRLAHELGAETATLS 321
Cdd:PRK10490 241 QGEEKVWHTRDAILLCIGHNTGSEKLVRTAARLAARLGSVWHAVYVETPRLHRLPEKKRRAILSALRLAQELGAETATLS 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  322 DPNKEKAVLRYAREHNLGKILIGRRCTSKqklfgWQWRSGFADRLGKLGPDLDLVIVALEER--SHWDKEQDNRSVSEKW 399
Cdd:PRK10490 321 DPAEEKAVLRYAREHNLGKIIIGRRASRR-----WWRRESFADRLARLGPDLDLVIVALDEPpaRAIAKAPDSRPFKEKW 395
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  400 RVQIQGCLIAIALCTLITLFSRTFLLTLDKANLVTLYLLGVVVIALFYGRRPSIFAAFINVISFDIFFVQPHWSLAVTDM 479
Cdd:PRK10490 396 RVQIQGCLVAIALCALITLIAMQWLPAFDAANLVMLYLLGVVVVALFYGRWPSVVATVINVASFDLFFVAPRGTLAVSDV 475
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  480 QYLLTFSVMLIVGVVVGNLTAGMRYQARIARYREQRTRNLYEMTRELSRALNEEDIARTSYHFLTNGFQAKTGLFLPNDD 559
Cdd:PRK10490 476 QYLLTFAVMLTVGLVIGNLTAGVRYQARVARYREQRTRHLYEMSKALAVGLSPEDIAATSEHFLASTFQARSQLLLPDDN 555
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  560 GNLYQLTTNNgGHMLIDDAIAKWSFDKNLPAGAGTDTLPSVPYQLQPIATPSQTLAVLAIEPSYLRQLLIPEQQRLLQTF 639
Cdd:PRK10490 556 GKLQPLTHDQ-GMTPWDDAIARWSFDKGQPAGAGTDTLPGVPYQILPLKSAQKTYGLLAVEPGNLRQLMIPEQQRLLETF 634
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  640 TGLIANALERLQLSRRAESAKLDTEREQLRNSLLAALSHDLRTPLTVLFGQAEILMLDLSAEGSPHTKQVNQIRQQILST 719
Cdd:PRK10490 635 TLLIANALERLTLTASEEQARLASEREQLRNALLAALSHDLRTPLTVLFGQAEILTLDLASEGSPHARQASEIRQQVLNT 714
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  720 SRLVNNLLDMARIQSGGIQLNLEWQSLEEIVGSTLRSLEYALNRHPVAVSLPSDL-LLHCDASLLERVFINLLENAIKYT 798
Cdd:PRK10490 715 TRLVNNLLDMARIQSGGFNLRKEWLTLEEVVGSALQMLEPGLSGHPINLSLPEPLtLIHVDGPLFERVLINLLENAVKYA 794
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  799 DEQIPLGIKATTEKNQIHIEVWDAGKGIPPEQEQLIFDKFSRARKESAIPGVGLGLAICRAIIEIHQGKIWASNNEKGGA 878
Cdd:PRK10490 795 GAQAEIGIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDKFARGNKESAIPGVGLGLAICRAIVEVHGGTIWAENRPEGGA 874
                        890       900
                 ....*....|....*....|.
gi 37525371  879 SFHFVLPLEKPPEI--ITEEM 897
Cdd:PRK10490 875 CFRVTLPLETPPELeeFHEDM 895
KdpD pfam02702
Osmosensitive K+ channel His kinase sensor domain; This is a family of KdpD sensor kinase ...
22-231 4.88e-135

Osmosensitive K+ channel His kinase sensor domain; This is a family of KdpD sensor kinase proteins that regulate the kdpFABC operon responsible for potassium transport. The aligned region corresponds to the N-terminal cytoplasmic part of the protein which functions as the sensor domain responsible for sensing turgor pressure. It recognizes C-di-AMP and K+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 460656 [Multi-domain]  Cd Length: 210  Bit Score: 401.41  E-value: 4.88e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371    22 QRGKLKIFFGACAGVGKTYAMLQEAQRLRAQGLDVVIGVVETHERQGTAALLDGLPQLPLKQIYYRRRKISVFDLDAAIA 101
Cdd:pfam02702   1 RRGRLKIFLGAAPGVGKTYAMLQEAHRLKKRGVDVVIGYVETHGRPETEALLEGLEVIPRREIEYRGRTLEEMDLDAILA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371   102 RHPAIILMDELAFSNPHTNRHPKRWQDVEELLEAGIDVLTTINVQHLESLNDVVGDITGIRVRETIPDHIFDQANEIVLV 181
Cdd:pfam02702  81 RRPEVVLVDELAHTNAPGSRHPKRWQDVEELLDAGIDVYTTVNIQHLESLNDVVEQITGVRVRETVPDSVLDRADEVELV 160
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 37525371   182 DLPPDDLRQRLNEGKVYIPSQAERAIEHFFRKGNLIALRELALRRTADRV 231
Cdd:pfam02702 161 DLTPEELLERLKEGKVYPPEKAERALKNFFRKGNLTALRELALRRVADRV 210
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
651-889 3.03e-77

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 251.36  E-value: 3.03e-77
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 651 QLSRRAESAKldtEREQLRNSLLAALSHDLRTPLTVLFGQAEILMLDLSAEGSPHTKQVNQIRQQILSTSRLVNNLLDMA 730
Cdd:COG2205   1 ELEEALEELE---ELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERRELLEIIRESAERLLRLIEDLLDLS 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 731 RIQSGGIQLNLEWQSLEEIVGSTLRSLEYALNRHPVAVSL---PSDLLLHCDASLLERVFINLLENAIKYTDEQIPLGIK 807
Cdd:COG2205  78 RLESGKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELdlpPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITIS 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 808 ATTEKNQIHIEVWDAGKGIPPEQEQLIFDKFSRARKESAIPGVGLGLAICRAIIEIHQGKIWASNNEKGGASFHFVLPLE 887
Cdd:COG2205 158 ARREGDGVRISVSDNGPGIPEEELERIFERFYRGDNSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPLA 237

                ..
gi 37525371 888 KP 889
Cdd:COG2205 238 ES 239
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
779-887 2.25e-35

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 130.08  E-value: 2.25e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371    779 DASLLERVFINLLENAIKYTDEQIPLGIKATTEKNQIHIEVWDAGKGIPPEQEQLIFDKFSRARK-ESAIPGVGLGLAIC 857
Cdd:smart00387   2 DPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKrSRKIGGTGLGLSIV 81
                           90       100       110
                   ....*....|....*....|....*....|
gi 37525371    858 RAIIEIHQGKIWASNNEKGGASFHFVLPLE 887
Cdd:smart00387  82 KKLVELHGGEISVESEPGGGTTFTITLPLE 111
USP_KdpD-like cd01987
USP domain of the osmosensitive K+ channel histidine kinase family; The KdpDE two component ...
254-379 1.01e-34

USP domain of the osmosensitive K+ channel histidine kinase family; The KdpDE two component system is widespread in bacteria and archaea; it controls potassium homeostasis and virulence by regulating the transcription of multiple genes, including a kdpFABC operon, which encodes a high-affinity P-type ATPase transporter. The KdpD histidine kinase (HK, EC:2.7.13.3) contain an N-terminal sensory cytoplasmic region (NTR) composed of KdpD' and universal stress protein (USP) domains, a canonical transmembrane domain, and a cytoplasmic C-terminal region with a transmitter GAF domain and an EnvZ-like catalytic HK domain. Proteins containing the USP domain are induced by many environmental stressors such as nutrient starvation, drought, extreme temperatures, high salinity, and the presence of uncouplers, antibiotics, and metals. It enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity.


Pssm-ID: 467491 [Multi-domain]  Cd Length: 124  Bit Score: 128.52  E-value: 1.01e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 254 LLLCIGNSSGNEKLIRTAARLAARLGCIWHAIYVETPKLYQLPEGKRRSILKALRLAHELGAETATLSDPNKEKAVLRYA 333
Cdd:cd01987   2 ILVCISSSPTSEKLIRRAARLAERLNGELTAVYVETPEESRLDEESQRRLLTNLKLAEELGAEVVSVEGDDVAEAIVEFA 81
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 37525371 334 REHNLGKILIGRrctSKQKLFGWQWRSGFADRLGKLGPDLDLVIVA 379
Cdd:cd01987  82 RERNVTQIVLGQ---SRRRRWRRLFKGSLVDRLLREAPNIDVHIVP 124
cztS_silS_copS TIGR01386
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ...
674-884 1.14e-22

heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.


Pssm-ID: 273593 [Multi-domain]  Cd Length: 457  Bit Score: 102.08  E-value: 1.14e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371   674 AALSHDLRTPLTVLFGQAEILmldLSAEGS-PHTKQV---NQIRQQILstSRLVNNLLDMARIQSGGIQLNLEWQSLEEI 749
Cdd:TIGR01386 246 ADLAHELRTPLTNLLGQTQVA---LSQPRTgEEYREVlesNLEELERL--SRMVSDMLFLARADNGQLALERVRLDLAAE 320
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371   750 VGSTLRSLEYALNRHPVAVSLPSDLLLHCDASLLERVFINLLENAIKYTDEQIPLGIKATTEKNQIHIEVWDAGKGIPPE 829
Cdd:TIGR01386 321 LAKVAEYFEPLAEERGVRIRVEGEGLVRGDPQMFRRAISNLLSNALRHTPDGGTITVRIERRSDEVRVSVSNPGPGIPPE 400
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 37525371   830 QEQLIFDKFSR---ARKESAiPGVGLGLAICRAIIEIHQGKIWAsnnEKGGASFHFVL 884
Cdd:TIGR01386 401 HLSRLFDRFYRvdpARSNSG-EGTGLGLAIVRSIMEAHGGRASA---ESPDGKTRFIL 454
 
Name Accession Description Interval E-value
PRK10490 PRK10490
sensor protein KdpD; Provisional
2-897 0e+00

sensor protein KdpD; Provisional


Pssm-ID: 236701 [Multi-domain]  Cd Length: 895  Bit Score: 1874.72  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371    2 DQHEPQRPDPDELLTLVNEKQRGKLKIFFGACAGVGKTYAMLQEAQRLRAQGLDVVIGVVETHERQGTAALLDGLPQLPL 81
Cdd:PRK10490   1 MNNEPLRPDPDRLLEQTAEPHRGKLKIFFGACAGVGKTYAMLQEAQRLRAQGLDVLVGVVETHGRKETAALLEGLTVLPP 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371   82 KQIYYRRRKISVFDLDAAIARHPAIILMDELAFSNPHTNRHPKRWQDVEELLEAGIDVLTTINVQHLESLNDVVGDITGI 161
Cdd:PRK10490  81 KRIHHRGRHISEFDLDAALARRPALILMDELAHSNAPGSRHPKRWQDVEELLEAGIDVFTTVNVQHLESLNDVVGGVTGI 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  162 RVRETIPDHIFDQANEIVLVDLPPDDLRQRLNEGKVYIPSQAERAIEHFFRKGNLIALRELALRRTADRVDDQMRAFRDT 241
Cdd:PRK10490 161 QVRETVPDPFFDAADEVVLVDLPPDDLRQRLNEGKVYIAGQAERAIEHFFRKGNLIALRELALRRTADRVDDQMRAWRDH 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  242 QGHEPVWHTRDNLLLCIGNSSGNEKLIRTAARLAARLGCIWHAIYVETPKLYQLPEGKRRSILKALRLAHELGAETATLS 321
Cdd:PRK10490 241 QGEEKVWHTRDAILLCIGHNTGSEKLVRTAARLAARLGSVWHAVYVETPRLHRLPEKKRRAILSALRLAQELGAETATLS 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  322 DPNKEKAVLRYAREHNLGKILIGRRCTSKqklfgWQWRSGFADRLGKLGPDLDLVIVALEER--SHWDKEQDNRSVSEKW 399
Cdd:PRK10490 321 DPAEEKAVLRYAREHNLGKIIIGRRASRR-----WWRRESFADRLARLGPDLDLVIVALDEPpaRAIAKAPDSRPFKEKW 395
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  400 RVQIQGCLIAIALCTLITLFSRTFLLTLDKANLVTLYLLGVVVIALFYGRRPSIFAAFINVISFDIFFVQPHWSLAVTDM 479
Cdd:PRK10490 396 RVQIQGCLVAIALCALITLIAMQWLPAFDAANLVMLYLLGVVVVALFYGRWPSVVATVINVASFDLFFVAPRGTLAVSDV 475
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  480 QYLLTFSVMLIVGVVVGNLTAGMRYQARIARYREQRTRNLYEMTRELSRALNEEDIARTSYHFLTNGFQAKTGLFLPNDD 559
Cdd:PRK10490 476 QYLLTFAVMLTVGLVIGNLTAGVRYQARVARYREQRTRHLYEMSKALAVGLSPEDIAATSEHFLASTFQARSQLLLPDDN 555
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  560 GNLYQLTTNNgGHMLIDDAIAKWSFDKNLPAGAGTDTLPSVPYQLQPIATPSQTLAVLAIEPSYLRQLLIPEQQRLLQTF 639
Cdd:PRK10490 556 GKLQPLTHDQ-GMTPWDDAIARWSFDKGQPAGAGTDTLPGVPYQILPLKSAQKTYGLLAVEPGNLRQLMIPEQQRLLETF 634
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  640 TGLIANALERLQLSRRAESAKLDTEREQLRNSLLAALSHDLRTPLTVLFGQAEILMLDLSAEGSPHTKQVNQIRQQILST 719
Cdd:PRK10490 635 TLLIANALERLTLTASEEQARLASEREQLRNALLAALSHDLRTPLTVLFGQAEILTLDLASEGSPHARQASEIRQQVLNT 714
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  720 SRLVNNLLDMARIQSGGIQLNLEWQSLEEIVGSTLRSLEYALNRHPVAVSLPSDL-LLHCDASLLERVFINLLENAIKYT 798
Cdd:PRK10490 715 TRLVNNLLDMARIQSGGFNLRKEWLTLEEVVGSALQMLEPGLSGHPINLSLPEPLtLIHVDGPLFERVLINLLENAVKYA 794
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  799 DEQIPLGIKATTEKNQIHIEVWDAGKGIPPEQEQLIFDKFSRARKESAIPGVGLGLAICRAIIEIHQGKIWASNNEKGGA 878
Cdd:PRK10490 795 GAQAEIGIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDKFARGNKESAIPGVGLGLAICRAIVEVHGGTIWAENRPEGGA 874
                        890       900
                 ....*....|....*....|.
gi 37525371  879 SFHFVLPLEKPPEI--ITEEM 897
Cdd:PRK10490 875 CFRVTLPLETPPELeeFHEDM 895
KdpD pfam02702
Osmosensitive K+ channel His kinase sensor domain; This is a family of KdpD sensor kinase ...
22-231 4.88e-135

Osmosensitive K+ channel His kinase sensor domain; This is a family of KdpD sensor kinase proteins that regulate the kdpFABC operon responsible for potassium transport. The aligned region corresponds to the N-terminal cytoplasmic part of the protein which functions as the sensor domain responsible for sensing turgor pressure. It recognizes C-di-AMP and K+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 460656 [Multi-domain]  Cd Length: 210  Bit Score: 401.41  E-value: 4.88e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371    22 QRGKLKIFFGACAGVGKTYAMLQEAQRLRAQGLDVVIGVVETHERQGTAALLDGLPQLPLKQIYYRRRKISVFDLDAAIA 101
Cdd:pfam02702   1 RRGRLKIFLGAAPGVGKTYAMLQEAHRLKKRGVDVVIGYVETHGRPETEALLEGLEVIPRREIEYRGRTLEEMDLDAILA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371   102 RHPAIILMDELAFSNPHTNRHPKRWQDVEELLEAGIDVLTTINVQHLESLNDVVGDITGIRVRETIPDHIFDQANEIVLV 181
Cdd:pfam02702  81 RRPEVVLVDELAHTNAPGSRHPKRWQDVEELLDAGIDVYTTVNIQHLESLNDVVEQITGVRVRETVPDSVLDRADEVELV 160
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 37525371   182 DLPPDDLRQRLNEGKVYIPSQAERAIEHFFRKGNLIALRELALRRTADRV 231
Cdd:pfam02702 161 DLTPEELLERLKEGKVYPPEKAERALKNFFRKGNLTALRELALRRVADRV 210
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
651-889 3.03e-77

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 251.36  E-value: 3.03e-77
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 651 QLSRRAESAKldtEREQLRNSLLAALSHDLRTPLTVLFGQAEILMLDLSAEGSPHTKQVNQIRQQILSTSRLVNNLLDMA 730
Cdd:COG2205   1 ELEEALEELE---ELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERRELLEIIRESAERLLRLIEDLLDLS 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 731 RIQSGGIQLNLEWQSLEEIVGSTLRSLEYALNRHPVAVSL---PSDLLLHCDASLLERVFINLLENAIKYTDEQIPLGIK 807
Cdd:COG2205  78 RLESGKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELdlpPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITIS 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 808 ATTEKNQIHIEVWDAGKGIPPEQEQLIFDKFSRARKESAIPGVGLGLAICRAIIEIHQGKIWASNNEKGGASFHFVLPLE 887
Cdd:COG2205 158 ARREGDGVRISVSDNGPGIPEEELERIFERFYRGDNSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPLA 237

                ..
gi 37525371 888 KP 889
Cdd:COG2205 238 ES 239
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
498-889 2.62e-61

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 213.26  E-value: 2.62e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 498 LTAGMRYQARIARYREQRTRNLYEMTRELSRALNEEDIARTSYHFLTNGFQAKTGLFLPNDDGNLYQLTTNNGGHMLIDD 577
Cdd:COG5002   1 LLLLLLLLLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 578 AIAKWSFDKNLPAGAGTDTLPSVPYQLQPIATPSQTLAVLAIEPSYLRQLLIPEQQRLLQTFTGLIANALERLQLSRRAE 657
Cdd:COG5002  81 LALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELER 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 658 SakldterEQLRNSLLAALSHDLRTPLTVLFGQAEILMLDLSAEGSPHTKQVNQIRQQILSTSRLVNNLLDMARIQSGGI 737
Cdd:COG5002 161 L-------EQMRREFVANVSHELRTPLTSIRGYLELLLDGAADDPEERREYLEIILEEAERLSRLVNDLLDLSRLESGEL 233
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 738 QLNLEWQSLEEIVGSTLRSLEYALNRHPVAVSL---PSDLLLHCDASLLERVFINLLENAIKYTDEQIPLGIKATTEKNQ 814
Cdd:COG5002 234 KLEKEPVDLAELLEEVVEELRPLAEEKGIELELdlpEDPLLVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLREEDDQ 313
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 37525371 815 IHIEVWDAGKGIPPEQEQLIFDKFSRARKE--SAIPGVGLGLAICRAIIEIHQGKIWASNNEKGGASFHFVLPLEKP 889
Cdd:COG5002 314 VRISVRDTGIGIPEEDLPRIFERFYRVDKSrsRETGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITLPLARE 390
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
574-887 1.67e-59

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 206.30  E-value: 1.67e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 574 LIDDAIAKWSFDKNLPAGAGTDTLPSVPYQLQPIATPSQTLAVLAIEPSYLRQLLIPEQQRLLQTFTGLIANALERLQLS 653
Cdd:COG0642  18 LLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 654 RRAESAKldtEREQLRNSLLAALSHDLRTPLTVLFGQAEILMLDLSAEgspHTKQVNQIRQQILSTSRLVNNLLDMARIQ 733
Cdd:COG0642  98 ALLLLLE---EANEAKSRFLANVSHELRTPLTAIRGYLELLLEELDEE---QREYLETILRSADRLLRLINDLLDLSRLE 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 734 SGGIQLNLEWQSLEEIVGSTLRSLEYALNRHPVAVSL---PSDLLLHCDASLLERVFINLLENAIKYTDEQIPLGIKATT 810
Cdd:COG0642 172 AGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELdlpDDLPTVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVSVRR 251
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 37525371 811 EKNQIHIEVWDAGKGIPPEQEQLIFDKFSRARKESAIPGVGLGLAICRAIIEIHQGKIWASNNEKGGASFHFVLPLE 887
Cdd:COG0642 252 EGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRGGGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTLPLA 328
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
399-889 3.55e-45

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 170.74  E-value: 3.55e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 399 WRVQIQGCLIAIALCTLITLFSRTFLLTLDKANLVTLYLLGVVVIALFYGRRPSIFAAFINVISFDIFFVQPHWSLAVTD 478
Cdd:COG4251   8 LLLLLLLLLLLLLLLLLLLVLLLALALLLLLALLVLLLLLIRLLLLLLLSLLALLLLLLLLLLLLLVLAALALLLLLLLL 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 479 MQYLLTFSVMLIVGVVVGNLTAGMRYQARIARYREQRTRNLYEMTRELSRALNEEDIARTSYHFLTNGFQAKTGLFLPND 558
Cdd:COG4251  88 ELALVLLALLLVLLLLLALLLLLALLLLLELLLLLLALLLLLLLLALLLLEELALLRLALALLLLLLLLLLLLLLLLALI 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 559 DGNLYQLTTNNGGHMLIDDAIAKWSFDKNLPAGAGTDTLPSVPYQLQPIATPSQTLAVLAIEPSYLRQLLIPEQQRLLQT 638
Cdd:COG4251 168 LALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLLLILLLLL 247
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 639 FTGLIANALERLQLSRRAESAKLDTEREQLRNSLLAAL----SHDLRTPLTVLFGQAEILMLDLSAEGSPHTKQ-VNQIR 713
Cdd:COG4251 248 LILVLELLELRLELEELEEELEERTAELERSNEELEQFayvaSHDLREPLRKISGFSQLLEEDYGDKLDEEGREyLERIR 327
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 714 QQILSTSRLVNNLLDMARIQSGgiQLNLEWQSLEEIVGSTLRSLEYALNRHPVAVSLPSDLLLHCDASLLERVFINLLEN 793
Cdd:COG4251 328 DAAERMQALIDDLLAYSRVGRQ--ELEFEPVDLNELLEEVLEDLEPRIEERGAEIEVGPLPTVRGDPTLLRQVFQNLISN 405
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 794 AIKYTDEQIP--LGIKATTEKNQIHIEVWDAGKGIPPEQEQLIFDKFSRARKESAIPGVGLGLAICRAIIEIHQGKIWAS 871
Cdd:COG4251 406 AIKYSRPGEPprIEIGAEREGGEWVFSVRDNGIGIDPEYAEKIFEIFQRLHSRDEYEGTGIGLAIVKKIVERHGGRIWVE 485
                       490
                ....*....|....*...
gi 37525371 872 NNEKGGASFHFVLPLEKP 889
Cdd:COG4251 486 SEPGEGATFYFTLPKAPA 503
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
614-886 6.10e-40

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 151.49  E-value: 6.10e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 614 LAVLAIEPSYLRQLLIPEQQRLLQTFTGLIANALERLQLSRRAESAKLDTEREQLRNS--------LLAALSHDLRTPLT 685
Cdd:COG4191  79 LLLLGLLLLLLLEALLLLLLAALDAEENAELEELERDITELERAEEELRELQEQLVQSeklaalgeLAAGIAHEINNPLA 158
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 686 VLFGQAEILMLDLSAEGSPH--TKQVNQIRQQILSTSRLVNNLLDMARIQSggiqLNLEWQSLEEIVGSTLRSLEYALNR 763
Cdd:COG4191 159 AILGNAELLRRRLEDEPDPEelREALERILEGAERAAEIVRSLRAFSRRDE----EEREPVDLNELIDEALELLRPRLKA 234
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 764 HPVAVSL---PSDLLLHCDASLLERVFINLLENAIKYTDEQIP--LGIKATTEKNQIHIEVWDAGKGIPPEQEQLIFDKF 838
Cdd:COG4191 235 RGIEVELdlpPDLPPVLGDPGQLEQVLLNLLINAIDAMEEGEGgrITISTRREGDYVVISVRDNGPGIPPEVLERIFEPF 314
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 37525371 839 --SRARKEsaipGVGLGLAICRAIIEIHQGKIWASNNEKGGASFHFVLPL 886
Cdd:COG4191 315 ftTKPVGK----GTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLPL 360
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
672-891 2.32e-39

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 151.65  E-value: 2.32e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 672 LLAALSHDLRTPLTVLFGQAEILMLDLSAEGSPHTKQVNQ----IRQQILSTSRLVNNLLDMARIQsggiQLNLEWQSLE 747
Cdd:COG5000 204 LARRIAHEIKNPLTPIQLSAERLRRKLADKLEEDREDLERaldtIIRQVDRLKRIVDEFLDFARLP----EPQLEPVDLN 279
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 748 EIVGSTLRSLEYALNRHPVAVSL---PSDLLLHCDASLLERVFINLLENAIKYTDEQIPLGIKATTEKNQIHIEVWDAGK 824
Cdd:COG5000 280 ELLREVLALYEPALKEKDIRLELdldPDLPEVLADRDQLEQVLINLLKNAIEAIEEGGEIEVSTRREDGRVRIEVSDNGP 359
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 37525371 825 GIPPEQEQLIFDKF--SRARkesaipGVGLGLAICRAIIEIHQGKIWASNNEKGGASFHFVLPLEKPPE 891
Cdd:COG5000 360 GIPEEVLERIFEPFftTKPK------GTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRLPLAEEAE 422
DUF4118 pfam13493
Domain of unknown function (DUF4118); This domain is found in a wide variety of bacterial ...
407-512 4.03e-37

Domain of unknown function (DUF4118); This domain is found in a wide variety of bacterial signalling proteins. It is likely to be a transmembrane domain involved in ligand sensing.


Pssm-ID: 463897  Cd Length: 107  Bit Score: 134.89  E-value: 4.03e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371   407 LIAIALCTLITLFSRTFLLTLDKANLVTLYLLGVVVIALFYGRRPSIFAAFINVISFDIFFVQPHWSLAVTDMQYLLTFS 486
Cdd:pfam13493   2 LLAVLILALATLLALLLRPLLPLANIALLFLLAVLLVALRGGRGPGLLAAVLSVLLFNYFFTPPYFTFTVSDPGYLLTLV 81
                          90       100
                  ....*....|....*....|....*.
gi 37525371   487 VMLIVGVVVGNLTAGMRYQARIARYR 512
Cdd:pfam13493  82 VFLLVALLTSTLTARLRRQARQARRR 107
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
779-887 2.25e-35

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 130.08  E-value: 2.25e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371    779 DASLLERVFINLLENAIKYTDEQIPLGIKATTEKNQIHIEVWDAGKGIPPEQEQLIFDKFSRARK-ESAIPGVGLGLAIC 857
Cdd:smart00387   2 DPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKrSRKIGGTGLGLSIV 81
                           90       100       110
                   ....*....|....*....|....*....|
gi 37525371    858 RAIIEIHQGKIWASNNEKGGASFHFVLPLE 887
Cdd:smart00387  82 KKLVELHGGEISVESEPGGGTTFTITLPLE 111
USP_KdpD-like cd01987
USP domain of the osmosensitive K+ channel histidine kinase family; The KdpDE two component ...
254-379 1.01e-34

USP domain of the osmosensitive K+ channel histidine kinase family; The KdpDE two component system is widespread in bacteria and archaea; it controls potassium homeostasis and virulence by regulating the transcription of multiple genes, including a kdpFABC operon, which encodes a high-affinity P-type ATPase transporter. The KdpD histidine kinase (HK, EC:2.7.13.3) contain an N-terminal sensory cytoplasmic region (NTR) composed of KdpD' and universal stress protein (USP) domains, a canonical transmembrane domain, and a cytoplasmic C-terminal region with a transmitter GAF domain and an EnvZ-like catalytic HK domain. Proteins containing the USP domain are induced by many environmental stressors such as nutrient starvation, drought, extreme temperatures, high salinity, and the presence of uncouplers, antibiotics, and metals. It enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity.


Pssm-ID: 467491 [Multi-domain]  Cd Length: 124  Bit Score: 128.52  E-value: 1.01e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 254 LLLCIGNSSGNEKLIRTAARLAARLGCIWHAIYVETPKLYQLPEGKRRSILKALRLAHELGAETATLSDPNKEKAVLRYA 333
Cdd:cd01987   2 ILVCISSSPTSEKLIRRAARLAERLNGELTAVYVETPEESRLDEESQRRLLTNLKLAEELGAEVVSVEGDDVAEAIVEFA 81
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 37525371 334 REHNLGKILIGRrctSKQKLFGWQWRSGFADRLGKLGPDLDLVIVA 379
Cdd:cd01987  82 RERNVTQIVLGQ---SRRRRWRRLFKGSLVDRLLREAPNIDVHIVP 124
PRK09303 PRK09303
histidine kinase;
610-885 2.04e-32

histidine kinase;


Pssm-ID: 236462 [Multi-domain]  Cd Length: 380  Bit Score: 130.07  E-value: 2.04e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  610 PSQTLAVLAIepsyLRQL--LIPEQQRLLQTFTGLIAN-----------ALERLQLSR-----RAESAKLdTEREQLRNS 671
Cdd:PRK09303  79 PRQVLAGSNI----FQQLknWWPRWQQEGATYSGLGENlqpseidsgrySQELLQLSDelfvlRQENETL-LEQLKFKDR 153
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  672 LLAALSHDLRTPLTvlfgqAEILMLDlsaegsphTKQVNQIRQQILSTSRLVNNLLDMARIQsggiqlnlewqsLEEI-- 749
Cdd:PRK09303 154 VLAMLAHDLRTPLT-----AASLALE--------TLELGQIDEDTELKPALIEQLQDQARRQ------------LEEIer 208
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  750 -------VGSTlRSLEYALNRHPVAVS------------------------LPSDL-LLHCDASLLERVFINLLENAIKY 797
Cdd:PRK09303 209 litdlleVGRT-RWEALRFNPQKLDLGslcqevilelekrwlaksleiqtdIPSDLpSVYADQERIRQVLLNLLDNAIKY 287
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  798 TDE--QIPLGI-KATTEKNQIHIEvwDAGKGIPPEQEQLIFDKFSRARKESAIPGVGLGLAICRAIIEIHQGKIWASNNE 874
Cdd:PRK09303 288 TPEggTITLSMlHRTTQKVQVSIC--DTGPGIPEEEQERIFEDRVRLPRDEGTEGYGIGLSVCRRIVRVHYGQIWVDSEP 365
                        330
                 ....*....|.
gi 37525371  875 KGGASFHFVLP 885
Cdd:PRK09303 366 GQGSCFHFTLP 376
HATPase cd00075
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ...
783-884 5.91e-32

Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.


Pssm-ID: 340391 [Multi-domain]  Cd Length: 102  Bit Score: 119.63  E-value: 5.91e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 783 LERVFINLLENAIKYTDEQIPLGIKATTEKNQIHIEVWDAGKGIPPEQEQLIFDKFSRARKESAIPGVGLGLAICRAIIE 862
Cdd:cd00075   1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSREGGGTGLGLAIVRRIVE 80
                        90       100
                ....*....|....*....|..
gi 37525371 863 IHQGKIWASNNEKGGASFHFVL 884
Cdd:cd00075  81 AHGGRITVESEPGGGTTFTVTL 102
PRK10549 PRK10549
two-component system sensor histidine kinase BaeS;
631-891 7.89e-30

two-component system sensor histidine kinase BaeS;


Pssm-ID: 182539 [Multi-domain]  Cd Length: 466  Bit Score: 123.97  E-value: 7.89e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  631 EQQRLLQTFTGLiANALERlqlsrraesakldteREQLRNSLLAALSHDLRTPLTVLFGQAEIL-----------MLDLS 699
Cdd:PRK10549 218 ELGRLAQDFNQL-ASTLEK---------------NEQMRRDFMADISHELRTPLAVLRGELEAIqdgvrkftpesVASLQ 281
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  700 AEGSPHTKQVNQIRQQILS---------TSRLVNNLLDMA------RIQSGGIQLNLewqsleeivgstlrsleyalnrh 764
Cdd:PRK10549 282 AEVGTLTKLVDDLHQLSLSdegalayrkTPVDLVPLLEVAggafreRFASRGLTLQL----------------------- 338
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  765 pvavSLPSDLLLHCDASLLERVFINLLENAIKYTDEQIPLGIKATTEKNQIHIEVWDAGKGIPPEQEQLIFDKFSRArkE 844
Cdd:PRK10549 339 ----SLPDSATVFGDPDRLMQLFNNLLENSLRYTDSGGSLHISAEQRDKTLRLTFADSAPGVSDEQLQKLFERFYRT--E 412
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 37525371  845 S----AIPGVGLGLAICRAIIEIHQGKIWASNNEKGGASFHFVLPLEKPPE 891
Cdd:PRK10549 413 GsrnrASGGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPLERDLQ 463
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
779-888 1.09e-29

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 113.62  E-value: 1.09e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371   779 DASLLERVFINLLENAIKYTDEQIPLGIKATtEKNQIHIEVWDAGKGIPPEQEQLIFDKFSRARKESAiPGVGLGLAICR 858
Cdd:pfam02518   2 DELRLRQVLSNLLDNALKHAAKAGEITVTLS-EGGELTLTVEDNGIGIPPEDLPRIFEPFSTADKRGG-GGTGLGLSIVR 79
                          90       100       110
                  ....*....|....*....|....*....|
gi 37525371   859 AIIEIHQGKIWASNNEKGGASFHFVLPLEK 888
Cdd:pfam02518  80 KLVELLGGTITVESEPGGGTTVTLTLPLAQ 109
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
663-895 1.66e-28

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 120.46  E-value: 1.66e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 663 TER----EQLRNS--------LLAALSHDLRTPLTVLFGQAEILMLDLSAEGSPH----TKQVNQIRQqilstsrLVNNL 726
Cdd:COG5809 252 TERkkleELLRKSeklsvvgeLAAGIAHEIRNPLTSLKGFIQLLKDTIDEEQKTYldimLSELDRIES-------IISEF 324
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 727 LDMARIQSGGIQLNlewqSLEEIVGSTLRSLEYALNRHPVAVSLPSDL---LLHCDASLLERVFINLLENAIKYTDEQIP 803
Cdd:COG5809 325 LVLAKPQAIKYEPK----DLNTLIEEVIPLLQPQALLKNVQIELELEDdipDILGDENQLKQVFINLLKNAIEAMPEGGN 400
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 804 LGIKAT-TEKNQIHIEVWDAGKGIPPEQEQLIFDKFSrARKESaipGVGLGLAICRAIIEIHQGKIWASNNEKGGASFHF 882
Cdd:COG5809 401 ITIETKaEDDDKVVISVTDEGCGIPEERLKKLGEPFY-TTKEK---GTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSI 476
                       250
                ....*....|...
gi 37525371 883 VLPLEKPPEIITE 895
Cdd:COG5809 477 TLPIKLSEQVSMN 489
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
648-891 1.57e-27

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 115.33  E-value: 1.57e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 648 ERLQLSRR-AESAKLDTEREqlrnsLLAALSHDLRTPLTVLFGQAEILMLDLSAEgsPHTKQVNQIRQQILSTSRLVNNL 726
Cdd:COG3852 118 ERKRLERElRRAEKLAAVGE-----LAAGLAHEIRNPLTGIRGAAQLLERELPDD--ELREYTQLIIEEADRLNNLVDRL 190
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 727 LDMARIQsggiQLNLEWQSLEEIVGSTLRSLEYALNRHpVAVSL---PSDLLLHCDASLLERVFINLLENAIKYTDE--- 800
Cdd:COG3852 191 LSFSRPR----PPEREPVNLHEVLERVLELLRAEAPKN-IRIVRdydPSLPEVLGDPDQLIQVLLNLVRNAAEAMPEggt 265
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 801 -------QIPLGIKATTEKNQIHIEVWDAGKGIPPEQEQLIFDKFSRARKEsaipGVGLGLAICRAIIEIHQGKIWASNN 873
Cdd:COG3852 266 itirtrvERQVTLGGLRPRLYVRIEVIDNGPGIPEEILDRIFEPFFTTKEK----GTGLGLAIVQKIVEQHGGTIEVESE 341
                       250
                ....*....|....*...
gi 37525371 874 EKGGASFHFVLPLEKPPE 891
Cdd:COG3852 342 PGKGTTFRIYLPLEQAEE 359
HATPase_CpxA-like cd16949
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
783-886 5.57e-27

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.


Pssm-ID: 340425 [Multi-domain]  Cd Length: 104  Bit Score: 105.87  E-value: 5.57e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 783 LERVFINLLENAIKYTDEQIPLGIkaTTEKNQIHIEVWDAGKGIPPEQEQLIFDKFSRA--RKESAIPGVGLGLAICRAI 860
Cdd:cd16949   1 LARALENVLRNALRYSPSKILLDI--SQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVdsARDRESGGTGLGLAIAERA 78
                        90       100
                ....*....|....*....|....*.
gi 37525371 861 IEIHQGKIWASNNEKGGASFHFVLPL 886
Cdd:cd16949  79 IEQHGGKIKASNRKPGGLRVRIWLPA 104
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
783-886 9.20e-24

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 96.79  E-value: 9.20e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 783 LERVFINLLENAIKYTDE-QIPLGIKA---TTEKNQIHIEVWDAGKGIPPEQEQLIFDKFSRA-----RKESaipGVGLG 853
Cdd:cd16922   1 LRQILLNLLGNAIKFTEEgEVTLRVSLeeeEEDGVQLRFSVEDTGIGIPEEQQARLFEPFSQAdssttRKYG---GTGLG 77
                        90       100       110
                ....*....|....*....|....*....|...
gi 37525371 854 LAICRAIIEIHQGKIWASNNEKGGASFHFVLPL 886
Cdd:cd16922  78 LAISKKLVELMGGDISVESEPGQGSTFTFTLPL 110
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
663-889 1.64e-23

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 106.21  E-value: 1.64e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  663 TEREQLRNSL-----LAAL-------SHDLRTPLTVLFGQAEILMLdlSAEGSPHTKQVNQIRQQILSTSRLVNNLLDMA 730
Cdd:PRK11360 372 TERKRLQRRVarqerLAALgelvagvAHEIRNPLTAIRGYVQIWRQ--QTSDPPSQEYLSVVLREVDRLNKVIDQLLEFS 449
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  731 RIQsggiQLNLEWQSLEEIVGSTLRSLEYAL--NRHPVAVSLPSDL-LLHCDASLLERVFINLLENAIkytdEQIPLGIK 807
Cdd:PRK11360 450 RPR----ESQWQPVSLNALVEEVLQLFQTAGvqARVDFETELDNELpPIWADPELLKQVLLNILINAV----QAISARGK 521
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  808 ATTE-----KNQIHIEVWDAGKGIPPEQEQLIFDKF--SRARkesaipGVGLGLAICRAIIEIHQGKIWASNNEKGGASF 880
Cdd:PRK11360 522 IRIRtwqysDGQVAVSIEDNGCGIDPELLKKIFDPFftTKAK------GTGLGLALSQRIINAHGGDIEVESEPGVGTTF 595

                 ....*....
gi 37525371  881 HFVLPLEKP 889
Cdd:PRK11360 596 TLYLPINPQ 604
PRK15347 PRK15347
two component system sensor kinase;
657-897 3.02e-23

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 106.26  E-value: 3.02e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  657 ESAKLDTEREQLRNSL-LAALSHDLRTPLTVLFGQAEILmldlsaegspHTKQVNQIRQQILSTSR--------LVNNLL 727
Cdd:PRK15347 385 AEAKQRAEQANKRKSEhLTTISHEIRTPLNGVLGALELL----------QNTPLTAEQMDLADTARqctlsllaIINNLL 454
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  728 DMARIQSGGIQLNLEWQSLEEIVGST-----LRSLEYALNRHP-VAVSLPsdLLLHCDASLLERVFINLLENAIKYTDE- 800
Cdd:PRK15347 455 DFSRIESGQMTLSLEETALLPLLDQAmltiqGPAQSKSLTLRTfVGAHVP--LYLHLDSLRLRQILVNLLGNAVKFTETg 532
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  801 QIPLGIKatTEKNQIHIEVWDAGKGIPPEQEQLIFDKFSRARKESAipGVGLGLAICRAIIEIHQGKIWASNNEKGGASF 880
Cdd:PRK15347 533 GIRLRVK--RHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADTHSQ--GTGLGLTIASSLAKMMGGELTLFSTPGVGSCF 608
                        250
                 ....*....|....*....
gi 37525371  881 HFVLPLE--KPPEIITEEM 897
Cdd:PRK15347 609 SLVLPLNeyAPPEPLKGEL 627
cztS_silS_copS TIGR01386
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ...
674-884 1.14e-22

heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.


Pssm-ID: 273593 [Multi-domain]  Cd Length: 457  Bit Score: 102.08  E-value: 1.14e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371   674 AALSHDLRTPLTVLFGQAEILmldLSAEGS-PHTKQV---NQIRQQILstSRLVNNLLDMARIQSGGIQLNLEWQSLEEI 749
Cdd:TIGR01386 246 ADLAHELRTPLTNLLGQTQVA---LSQPRTgEEYREVlesNLEELERL--SRMVSDMLFLARADNGQLALERVRLDLAAE 320
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371   750 VGSTLRSLEYALNRHPVAVSLPSDLLLHCDASLLERVFINLLENAIKYTDEQIPLGIKATTEKNQIHIEVWDAGKGIPPE 829
Cdd:TIGR01386 321 LAKVAEYFEPLAEERGVRIRVEGEGLVRGDPQMFRRAISNLLSNALRHTPDGGTITVRIERRSDEVRVSVSNPGPGIPPE 400
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 37525371   830 QEQLIFDKFSR---ARKESAiPGVGLGLAICRAIIEIHQGKIWAsnnEKGGASFHFVL 884
Cdd:TIGR01386 401 HLSRLFDRFYRvdpARSNSG-EGTGLGLAIVRSIMEAHGGRASA---ESPDGKTRFIL 454
HATPase_FilI-like cd16921
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
783-885 1.93e-22

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340398 [Multi-domain]  Cd Length: 105  Bit Score: 92.78  E-value: 1.93e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 783 LERVFINLLENAIKYTDEQIP--LGIKATTEKNQIHIEVWDAGKGIPPEQEQLIFDKFSRARKESAIPGVGLGLAICRAI 860
Cdd:cd16921   1 LGQVLTNLLGNAIKFRRPRRPprIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLHSREEYEGTGVGLAIVRKI 80
                        90       100
                ....*....|....*....|....*
gi 37525371 861 IEIHQGKIWASNNEKGGASFHFVLP 885
Cdd:cd16921  81 IERHGGRIWLESEPGEGTTFYFTLP 105
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
783-885 2.24e-22

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 92.46  E-value: 2.24e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 783 LERVFINLLENAIKYTDEQIP----LGIKATT-EKNQIHIEVWDAGKGIPPEQEQLIFDKFSRARKEsaipGVGLGLAIC 857
Cdd:cd16920   1 IQQVLINLVRNGIEAMSEGGCerreLTIRTSPaDDRAVTISVKDTGPGIAEEVAGQLFDPFYTTKSE----GLGMGLSIC 76
                        90       100
                ....*....|....*....|....*...
gi 37525371 858 RAIIEIHQGKIWASNNEKGGASFHFVLP 885
Cdd:cd16920  77 RSIIEAHGGRLSVESPAGGGATFQFTLP 104
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
649-886 4.50e-22

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 100.69  E-value: 4.50e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  649 RLQLSRRAESAKLDTEREQLRNSL---------LAALSHDLRTPLTVLFGQAEILMLDLSAEgsphTKQ--VNQIRQQIL 717
Cdd:PRK11100 227 PLPKLGSSELRELAQALESMRVKLegkayveqyVQTLTHELKSPLAAIRGAAELLQEDPPPE----DRArfTGNILTQSA 302
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  718 STSRLVNNLLDMARIQSGGIQLNLEWQSLEEIVGSTLRSLEYALNRHPVAVSL-PSDLLLHCDASLLERVFINLLENAIK 796
Cdd:PRK11100 303 RLQQLIDRLLELARLEQRQELEVLEPVALAALLEELVEAREAQAAAKGITLRLrPDDARVLGDPFLLRQALGNLLDNAID 382
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  797 YTDEQIPLGIKATTEKNQIHIEVWDAGKGIP-PEQEQlIFDKF-SRARKESAIPGVGLGLAICRAIIEIHQGKIWASNNE 874
Cdd:PRK11100 383 FSPEGGTITLSAEVDGEQVALSVEDQGPGIPdYALPR-IFERFySLPRPANGRKSTGLGLAFVREVARLHGGEVTLRNRP 461
                        250
                 ....*....|..
gi 37525371  875 KGGASFHFVLPL 886
Cdd:PRK11100 462 EGGVLATLTLPR 473
PRK10815 PRK10815
two-component system sensor histidine kinase PhoQ;
625-878 1.59e-21

two-component system sensor histidine kinase PhoQ;


Pssm-ID: 182754 [Multi-domain]  Cd Length: 485  Bit Score: 98.94  E-value: 1.59e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  625 RQLLIPEQQRLLqtfTGLIANaLERLqlsrraesakLDTERE---QLRNSLlAALSHDLRTPLTVL-------------- 687
Cdd:PRK10815 234 REQLDPNPPREL---TSLVRN-LNRL----------LKNERErytKYRTTL-TDLTHSLKTPLAVLqstlrslrsgkqms 298
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  688 FGQAEILMLDlsaegsphtkQVNQIRQQIlstsrlvNNLLDMARIQSGGIQLNLEWQSleeiVGSTLRSLEYALN----R 763
Cdd:PRK10815 299 VEQAEPIMLE----------QISRISQQI-------GYYLHRASMRSEHNLLSRELHS----VAPLLDNLTSALNkvyqR 357
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  764 HPVAVSL---PSDLLLHCDASLLErVFINLLENAIKYTDEQIPlgIKATTEKNQIHIEVWDAGKGIPPEQEQLIFDKFSR 840
Cdd:PRK10815 358 KGVNITLdisPEITFVGEKNDFME-VMGNVLDNACKYCLEFVE--ISARQTDEHLHIVVEDDGPGIPESKRELIFDRGQR 434
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 37525371  841 ArkESAIPGVGLGLAICRAIIEIHQGKIWASNNEKGGA 878
Cdd:PRK10815 435 A--DTLRPGQGLGLSVAREITEQYEGKISAGDSPLGGA 470
HATPase_BaeS-like cd16946
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
779-885 2.31e-21

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.


Pssm-ID: 340422 [Multi-domain]  Cd Length: 109  Bit Score: 89.83  E-value: 2.31e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 779 DASLLERVFINLLENAIKYTDEQIPLGIKATTEKNQIHIEVWDAGKGIPPEQEQLIFDKFSRAR--KESAIPGVGLGLAI 856
Cdd:cd16946   1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVEssRNRASGGSGLGLAI 80
                        90       100
                ....*....|....*....|....*....
gi 37525371 857 CRAIIEIHQGKIWASNNEKGGASFHFVLP 885
Cdd:cd16946  81 CHNIALAHGGTISAEHSPLGGLRLVLTLP 109
envZ PRK09467
osmolarity sensor protein; Provisional
666-887 3.57e-21

osmolarity sensor protein; Provisional


Pssm-ID: 236531 [Multi-domain]  Cd Length: 435  Bit Score: 97.29  E-value: 3.57e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  666 EQLRNSLLAALSHDLRTPLTVLFGQAEilML----DLSAEGSPH-TKQVNQIRQQILSTSRLVNnllDMARIQsggIQLN 740
Cdd:PRK09467 226 EDDRTLLMAGVSHDLRTPLTRIRLATE--MMseedGYLAESINKdIEECNAIIEQFIDYLRTGQ---EMPMEM---ADLN 297
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  741 lewQSLEEIVGSTL---RSLEYALNRHPVAVslpsdlllHCDASLLERVFINLLENAIKYTDEQIPlgIKATTEKNQIHI 817
Cdd:PRK09467 298 ---ALLGEVIAAESgyeREIETALQPGPIEV--------PMNPIAIKRALANLVVNAARYGNGWIK--VSSGTEGKRAWF 364
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 37525371  818 EVWDAGKGIPPEQEQLIFDKFSR---ARKESaipGVGLGLAICRAIIEIHQGKIWASNNEKGGASFHFVLPLE 887
Cdd:PRK09467 365 QVEDDGPGIPPEQLKHLFQPFTRgdsARGSS---GTGLGLAIVKRIVDQHNGKVELGNSEEGGLSARAWLPLT 434
PRK09959 PRK09959
acid-sensing system histidine kinase EvgS;
661-887 5.05e-21

acid-sensing system histidine kinase EvgS;


Pssm-ID: 182169 [Multi-domain]  Cd Length: 1197  Bit Score: 99.42  E-value: 5.05e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371   661 LDTEREQLRNS------LLAALSHDLRTPLTVLFGQAEILmldlSAEGSPHTKQVNQIR------QQILStsrLVNNLLD 728
Cdd:PRK09959  698 LEVERNKAINAtvaksqFLATMSHEIRTPISSIMGFLELL----SGSGLSKEQRVEAISlayatgQSLLG---LIGEILD 770
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371   729 MARIQSGGIQLNLEWQSLEEIVGSTLRSLEYALNRHPVAVS----LPSDLLLHCDASLLERVFINLLENAIKYTDEQipl 804
Cdd:PRK09959  771 VDKIESGNYQLQPQWVDIPTLVQNTCHSFGAIAASKSIALScsstFPDHYLVKIDPQAFKQVLSNLLSNALKFTTEG--- 847
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371   805 GIKATT-----EKNQ--IHIEVWDAGKGIPPEQEQLIFDKFSRARKESAIPGVGLGLAICRAIIEIHQGKIWASNNEKGG 877
Cdd:PRK09959  848 AVKITTslghiDDNHavIKMTIMDSGSGLSQEEQQQLFKRYSQTSAGRQQTGSGLGLMICKELIKNMQGDLSLESHPGIG 927
                         250
                  ....*....|
gi 37525371   878 ASFHFVLPLE 887
Cdd:PRK09959  928 TTFTITIPVE 937
PRK11466 PRK11466
hybrid sensory histidine kinase TorS; Provisional
655-889 5.23e-21

hybrid sensory histidine kinase TorS; Provisional


Pssm-ID: 236914 [Multi-domain]  Cd Length: 914  Bit Score: 99.21  E-value: 5.23e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  655 RAESAKLDtereQLRNSLLAALSHDLRTPLTVLFGQAEILMLD-LSAEGSPHTKQVNQIRQQILStsrLVNNLLDMARIQ 733
Cdd:PRK11466 434 RAEAEKAS----QAKSAFLAAMSHEIRTPLYGILGTAQLLADNpALNAQRDDLRAITDSGESLLT---ILNDILDYSAIE 506
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  734 SGG--IQLNLEWQSLEEIVGSTLRSLEYALNRHPVAVS------LPSdlLLHCDASLLERVFINLLENAIKYTDEQIpLG 805
Cdd:PRK11466 507 AGGknVSVSDEPFEPRPLLESTLQLMSGRVKGRPIRLAtdiaddLPT--ALMGDPRRIRQVITNLLSNALRFTDEGS-IV 583
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  806 IKATTEKNQIHIEVWDAGKGIPPEQEQLIFDKFSRARKESAipGVGLGLAICRAIIEIHQGKIWASNNEKGGASFHFVLP 885
Cdd:PRK11466 584 LRSRTDGEQWLVEVEDSGCGIDPAKLAEIFQPFVQVSGKRG--GTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLP 661

                 ....
gi 37525371  886 LEKP 889
Cdd:PRK11466 662 LRVA 665
cpxA PRK09470
envelope stress sensor histidine kinase CpxA;
671-889 4.64e-20

envelope stress sensor histidine kinase CpxA;


Pssm-ID: 236532 [Multi-domain]  Cd Length: 461  Bit Score: 94.23  E-value: 4.64e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  671 SLLAALSHDLRTPLTVLfgQ-AEILMLDLSAEGsphtKQVNQIRQQILSTSRLVNNLLDMARIQSGGiQLNLEWQSLEEI 749
Cdd:PRK09470 245 RLLSDISHELRTPLTRL--QlATALLRRRQGES----KELERIETEAQRLDSMINDLLVLSRNQQKN-HLERETFKANSL 317
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  750 VGSTLRSLEYA---LNRHPVAVSLPSDLLLHCDASLLERVFINLLENAIKYTDEQIPLGIKAttEKNQIHIEVWDAGKGI 826
Cdd:PRK09470 318 WSEVLEDAKFEaeqMGKSLTVSAPPGPWPINGNPNALASALENIVRNALRYSHTKIEVAFSV--DKDGLTITVDDDGPGV 395
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 37525371  827 PPEQEQLIFDKFSR---AR-KESAipGVGLGLAICRAIIEIHQGKIWASNNEKGGASFHFVLPLEKP 889
Cdd:PRK09470 396 PEEEREQIFRPFYRvdeARdRESG--GTGLGLAIVENAIQQHRGWVKAEDSPLGGLRLTIWLPLYKR 460
PRK10604 PRK10604
sensor protein RstB; Provisional
669-886 1.70e-19

sensor protein RstB; Provisional


Pssm-ID: 236724 [Multi-domain]  Cd Length: 433  Bit Score: 92.36  E-value: 1.70e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  669 RNSLLAALSHDLRTPLTVLFGQAEilMLDLSAEGSPHTkqvnqIRQQILSTSRLVNNLLDMARIQSGGIQLNLEWQSLEE 748
Cdd:PRK10604 212 KKQLIDGIAHELRTPLVRLRYRLE--MSDNLSAAESQA-----LNRDIGQLEALIEELLTYARLDRPQNELHLSEPDLPA 284
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  749 IVGSTLRslEYALNRHPVAVSL---PSDLLLHCDASLLERVFINLLENAIKYTDEQIPLGIkaTTEKNQIHIEVWDAGKG 825
Cdd:PRK10604 285 WLSTHLA--DIQAVTPEKTVRLdtpHQGDYGALDMRLMERVLDNLLNNALRYAHSRVRVSL--LLDGNQACLIVEDDGPG 360
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 37525371  826 IPPEQEQLIFDKFSR--ARKESAIPGVGLGLAICRAIIEIHQGKIWASNNEKGGASFHFVLPL 886
Cdd:PRK10604 361 IPPEERERVFEPFVRldPSRDRATGGCGLGLAIVHSIALAMGGSVNCDESELGGARFSFSWPV 423
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
672-886 9.09e-19

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 90.56  E-value: 9.09e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 672 LLAALSHDLRTPLTVLFGQaeILMLDLSAEGSPHTKQVnqIRQQILSTSRLVNNLLDMARIQSggiqLNLEWQSLEEIVG 751
Cdd:COG5805 290 LAAGIAHEIRNPLTSIKGF--LQLLQPGIEDKEEYFDI--MLSELDRIESIISEFLALAKPQA----VNKEKENINELIQ 361
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 752 STLRSLEYALNRHPVAVSLPS---DLLLHCDASLLERVFINLLENAIkytdEQIPLG----IKATTEKNQIHIEVWDAGK 824
Cdd:COG5805 362 DVVTLLETEAILHNIQIRLELldeDPFIYCDENQIKQVFINLIKNAI----EAMPNGgtitIHTEEEDNSVIIRVIDEGI 437
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 37525371 825 GIPPEQEQLIFDKFSrARKESaipGVGLGLAICRAIIEIHQGKIWASNNEKGGASFHFVLPL 886
Cdd:COG5805 438 GIPEERLKKLGEPFF-TTKEK---GTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLPL 495
HATPase_PhoQ-like cd16954
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
754-884 3.17e-18

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.


Pssm-ID: 340430 [Multi-domain]  Cd Length: 135  Bit Score: 81.91  E-value: 3.17e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 754 LRSLEYALNR-HP-----VAVSLPSDLLLHCDASLLERVFINLLENAIKYTDEQIPLGIKATteKNQIHIEVWDAGKGIP 827
Cdd:cd16954   3 LDSLCSALNKvYQrkgvsISLDISPELRFPGERNDLMELLGNLLDNACKWCLEFVEVTARQT--DGGLHLIVDDDGPGVP 80
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 37525371 828 PEQEQLIFDKFSRArkESAIPGVGLGLAICRAIIEIHQGKIWASNNEKGGASFHFVL 884
Cdd:cd16954  81 ESQRSKIFQRGQRL--DEQRPGQGLGLAIAKEIVEQYGGELSLSDSPLGGARFEVVF 135
HATPase_RstB-like cd16939
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
783-886 5.47e-18

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.


Pssm-ID: 340416 [Multi-domain]  Cd Length: 104  Bit Score: 80.17  E-value: 5.47e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 783 LERVFINLLENAIKYTDEQIPlgIKATTEKNQIHIEVWDAGKGIPPEQEQLIFDKFSR--ARKESAIPGVGLGLAICRAI 860
Cdd:cd16939   1 MARALDNLLRNALRYAHRTVR--IALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRldPSRDRATGGFGLGLAIVHRV 78
                        90       100
                ....*....|....*....|....*.
gi 37525371 861 IEIHQGKIWASNNEKGGASFHFVLPL 886
Cdd:cd16939  79 ALWHGGHVECDDSELGGACFRLTWPR 104
marine_sort_HK TIGR03785
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is ...
629-885 1.01e-17

proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is paired with an adjacent response regulator (TIGR03787) gene. It co-occurs with a variant sortase enzyme (TIGR03784), usually in the same gene neighborhood, in proteobacterial species most of which are marine, and with an LPXTG motif-containing sortase target conserved protein (TIGR03788). Sortases and LPXTG proteins are far more common in Gram-positive bacteria, where sortase systems mediate attachment to the cell wall or cross-linking of pilin structures. We give this predicted sensor histidine kinase the gene symbol psdS, for Proteobacterial Dedicated Sortase system Sensor histidine kinase.


Pssm-ID: 163497 [Multi-domain]  Cd Length: 703  Bit Score: 88.26  E-value: 1.01e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371   629 IPEQQRLLQTFTGLIANAlERLQLSRRAES--AKLDTEREQLRNsLLAALSHDLRTPLTVLFGQAEIL-MLDLSAEgspH 705
Cdd:TIGR03785 445 IDSQGRISGAIPASRSRD-EIGDLSRSFAQmvARLRQYTHYLEN-MSSRLSHELRTPVAVVRSSLENLeLQALEQE---K 519
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371   706 TKQVNQIRQQILSTSRLVNNLLDMARIQSGGIQLNLEWQSLEEIVGSTLRSLEYALNRHPVAVSLP-SDLLLHCDASLLE 784
Cdd:TIGR03785 520 QKYLERAREGTERLSMILNNMSEATRLEQAIQSAEVEDFDLSEVLSGCMQGYQMTYPPQRFELNIPeTPLVMRGSPELIA 599
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371   785 RVFINLLENAIKYTDEQIPLGIKATTEKNQIHIEVWDAGKGIPPEQEQLIFDKFSRARKESA--IPGVGLGLAICRAIIE 862
Cdd:TIGR03785 600 QMLDKLVDNAREFSPEDGLIEVGLSQNKSHALLTVSNEGPPLPEDMGEQLFDSMVSVRDQGAqdQPHLGLGLYIVRLIAD 679
                         250       260
                  ....*....|....*....|....
gi 37525371   863 IHQGKIWASNNEKG-GASFHFVLP 885
Cdd:TIGR03785 680 FHQGRIQAENRQQNdGVVFRISLP 703
HATPase_TutC-TodS-like cd16925
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ...
779-885 1.10e-17

Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.


Pssm-ID: 340402 [Multi-domain]  Cd Length: 110  Bit Score: 79.46  E-value: 1.10e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 779 DASLLERVFINLLENAIKYTdeqiPLG--IKATTEK---NQIHIEVWDAGKGIPPEQEQLIFDKFSRARKES--AIPGVG 851
Cdd:cd16925   1 DAEKYERVVLNLLSNAFKFT----PDGgrIRCILEKfrlNRFLLTVSDSGPGIPPNLREEIFERFRQGDGSStrAHGGTG 76
                        90       100       110
                ....*....|....*....|....*....|....
gi 37525371 852 LGLAICRAIIEIHQGKIWASNNEKGGASFHFVLP 885
Cdd:cd16925  77 LGLSIVKEFVELHGGTVTVSDAPGGGALFQVELP 110
PRK10364 PRK10364
two-component system sensor histidine kinase ZraS;
654-886 3.38e-17

two-component system sensor histidine kinase ZraS;


Pssm-ID: 236674 [Multi-domain]  Cd Length: 457  Bit Score: 85.22  E-value: 3.38e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  654 RRAESAKLDTEREQLRNSLLAAL-------SHDLRTPLTVLFGQAEILmldlsAEGSPHTKQVNQIRQQILST----SRL 722
Cdd:PRK10364 215 RRYLRSRQLLQDEMKRKEKLVALghlaagvAHEIRNPLSSIKGLAKYF-----AERAPAGGEAHQLAQVMAKEadrlNRV 289
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  723 VNNLLDMARIQsggiQLNLEWQSLEEIVGSTLRSLEYALNRHPVAVSL-PSDLL--LHCDASLLERVFINLLENAIKYTD 799
Cdd:PRK10364 290 VSELLELVKPT----HLALQAVDLNDLINHSLQLVSQDANSREIQLRFtANDTLpeIQADPDRLTQVLLNLYLNAIQAIG 365
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  800 EQIPLGIKATTEKNQIHIEVWDAGKGIPPEQEQLIFDKFSRARKEsaipGVGLGLAICRAIIEIHQGKIWASNNEKGGAS 879
Cdd:PRK10364 366 QHGVISVTASESGAGVKISVTDSGKGIAADQLEAIFTPYFTTKAE----GTGLGLAVVHNIVEQHGGTIQVASQEGKGAT 441

                 ....*..
gi 37525371  880 FHFVLPL 886
Cdd:PRK10364 442 FTLWLPV 448
HATPase_AtoS-like cd16943
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
781-886 1.48e-16

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.


Pssm-ID: 340419 [Multi-domain]  Cd Length: 105  Bit Score: 75.92  E-value: 1.48e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 781 SLLERVFINLLENAIKYTDEQIPLGIKATTEKNQIHIEVWDAGKGIPPEQEQLIFDKFSRARKESAipGVGLGLAICRAI 860
Cdd:cd16943   2 SQLNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPVGE--GTGLGLSLSYRI 79
                        90       100
                ....*....|....*....|....*.
gi 37525371 861 IEIHQGKIWASNNEKGGASFHFVLPL 886
Cdd:cd16943  80 IQKHGGTIRVASVPGGGTRFTIILPI 105
phoR PRK11006
phosphate regulon sensor histidine kinase PhoR;
663-885 2.58e-16

phosphate regulon sensor histidine kinase PhoR;


Pssm-ID: 182895 [Multi-domain]  Cd Length: 430  Bit Score: 82.37  E-value: 2.58e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  663 TEREQL---RNSLLAALSHDLRTPLTVLFGQAEiLMLDLSAEGSPHTKQVNQIRQQILSTSRLVNNLLDMARIQSGGIQL 739
Cdd:PRK11006 195 TQMHQLegaRRNFFANVSHELRTPLTVLQGYLE-MMQDQPLEGALREKALHTMREQTQRMEGLVKQLLTLSKIEAAPTID 273
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  740 nlewqsLEEIVG--STLRSLEY---AL--NRHPVAVSLPSDLLLHCDASLLERVFINLLENAIKYTDE--QIPLGIKATT 810
Cdd:PRK11006 274 ------LNEKVDvpMMLRVLEReaqTLsqGKHTITFEVDNSLKVFGNEDQLRSAISNLVYNAVNHTPEgtHITVRWQRVP 347
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 37525371  811 EKNQihIEVWDAGKGIPPEQEQLIFDKFSRARK--ESAIPGVGLGLAICRAIIEIHQGKIWASNNEKGGASFHFVLP 885
Cdd:PRK11006 348 QGAE--FSVEDNGPGIAPEHIPRLTERFYRVDKarSRQTGGSGLGLAIVKHALSHHDSRLEIESEVGKGTRFSFVLP 422
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
640-888 4.63e-16

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 81.05  E-value: 4.63e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 640 TGLIANALERLQLSRRAEsaKLDTEREQLRNslLAALSHDLRTPLTVLFGqaeilMLDLsaegsphtKQVNQIRQQILST 719
Cdd:COG3290 164 VGAVATFRDRTELERLEE--ELEGVKELAEA--LRAQRHDFRNHLHTISG-----LLQL--------GEYDEALEYIDEI 226
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 720 SRLVNNLLDMARIQSGgiqlnlewqslEEIVGSTLRS-LEYALNRHP-VAVSLPSDL-LLHCDASLLERVFINLLENAI- 795
Cdd:COG3290 227 SEELQELIDSLLSRIG-----------NPVLAALLLGkAARARERGIdLTIDIDSDLpDLPLSDTDLVTILGNLLDNAIe 295
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 796 ---KYTDEQIPLGIKATTEKNQIHIEVWDAGKGIPPEQEQLIFDK--FSRARKESaipgvGLGLAICRAIIEIHQGKIWA 870
Cdd:COG3290 296 aveKLPEEERRVELSIRDDGDELVIEVEDSGPGIPEELLEKIFERgfSTKLGEGR-----GLGLALVKQIVEKYGGTIEV 370
                       250
                ....*....|....*...
gi 37525371 871 SNNEKGGASFHFVLPLEK 888
Cdd:COG3290 371 ESEEGEGTVFTVRLPKEG 388
HATPase_EnvZ-like cd16950
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
783-885 5.49e-16

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.


Pssm-ID: 340426 [Multi-domain]  Cd Length: 101  Bit Score: 74.41  E-value: 5.49e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 783 LERVFINLLENAIKYTDEQIPlgIKATTEKNQIHIEVWDAGKGIPPEQEQLIFDKFSRARKESAIPGVGLGLAICRAIIE 862
Cdd:cd16950   1 LKRVLSNLVDNALRYGGGWVE--VSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARGTSGTGLGLAIVQRISD 78
                        90       100
                ....*....|....*....|...
gi 37525371 863 IHQGKIWASNNEKGGASFHFVLP 885
Cdd:cd16950  79 AHGGSLTLANRAGGGLCARIELP 101
HATPase_VanS-like cd16923
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
783-876 6.96e-16

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.


Pssm-ID: 340400 [Multi-domain]  Cd Length: 102  Bit Score: 73.96  E-value: 6.96e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 783 LERVFINLLENAIKYTDEQIPLGIKATTEKNQIHIEVWDAGKGIPPEQEQLIFDKFSRARKESAIPGVGLGLAICRAIIE 862
Cdd:cd16923   1 LQRVFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSRNTEGAGLGLSIAKAIIE 80
                        90
                ....*....|....
gi 37525371 863 IHQGKIWASNNEKG 876
Cdd:cd16923  81 LHGGSASAEYDDNH 94
PRK09835 PRK09835
Cu(+)/Ag(+) sensor histidine kinase;
674-885 1.52e-15

Cu(+)/Ag(+) sensor histidine kinase;


Pssm-ID: 182101 [Multi-domain]  Cd Length: 482  Bit Score: 80.20  E-value: 1.52e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  674 AALSHDLRTPLTVLFGQAEILmldLSAEGSPhtkqvNQIRQQILST-------SRLVNNLLDMAriQSGGIQLNLEWQSL 746
Cdd:PRK09835 267 ADIAHEIRTPITNLITQTEIA---LSQSRSQ-----KELEDVLYSNleeltrmAKMVSDMLFLA--QADNNQLIPEKKML 336
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  747 EeIVGSTLRSLEY----ALNRHpVAVSLPSDlllHC----DASLLERVFINLLENAIKYTDEQIPLGIKATTEKNQIHIE 818
Cdd:PRK09835 337 D-LADEVGKVFDFfeawAEERG-VELRFVGD---PCqvagDPLMLRRAISNLLSNALRYTPAGEAITVRCQEVDHQVQLV 411
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 37525371  819 VWDAGKGIPPEQEQLIFDKF-----SRARKESaipGVGLGLAICRAIIEIHQGKIWASNNEKgGASFHFVLP 885
Cdd:PRK09835 412 VENPGTPIAPEHLPRLFDRFyrvdpSRQRKGE---GSGIGLAIVKSIVVAHKGTVAVTSDAR-GTRFVISLP 479
PRK10337 PRK10337
sensor protein QseC; Provisional
678-877 2.04e-15

sensor protein QseC; Provisional


Pssm-ID: 182388 [Multi-domain]  Cd Length: 449  Bit Score: 79.69  E-value: 2.04e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  678 HDLRTPLTVLFGQAEILMLDLSAEGSPHtKQVNQIRQQILSTSRLVNNLLDMARIQSGGIQLNLEWQSLEEIVGSTLRS- 756
Cdd:PRK10337 246 HELRSPLAALKVQTEVAQLSDDDPQARK-KALLQLHAGIDRATRLVDQLLTLSRLDSLDNLQDVAEIPLEDLLQSAVMDi 324
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  757 ----------LEYALNRHPVAVSLPSDLLlhcdaSLLERvfiNLLENAIKYTdeqiPLGIKATTEKNQIHIEVWDAGKGI 826
Cdd:PRK10337 325 yhtaqqagidVRLTLNAHPVIRTGQPLLL-----SLLVR---NLLDNAIRYS----PQGSVVDVTLNARNFTVRDNGPGV 392
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 37525371  827 PPEQEQLIFDKFSRARKESAiPGVGLGLAICRAIIEIHQGKIWASNNEKGG 877
Cdd:PRK10337 393 TPEALARIGERFYRPPGQEA-TGSGLGLSIVRRIAKLHGMNVSFGNAPEGG 442
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
777-877 3.96e-15

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 72.05  E-value: 3.96e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 777 HCDASLLERVFINLLENAIKYT--DEQIPLGIKATTEKNqihIEVWDAGKGIPPEQEQLIFDKFSRARKESAiPGVGLGL 854
Cdd:cd16940   8 QGDALLLFLLLRNLVDNAVRYSpqGSRVEIKLSADDGAV---IRVEDNGPGIDEEELEALFERFYRSDGQNY-GGSGLGL 83
                        90       100
                ....*....|....*....|...
gi 37525371 855 AICRAIIEIHQGKIWASNNEKGG 877
Cdd:cd16940  84 SIVKRIVELHGGQIFLGNAQGGG 106
PRK10755 PRK10755
two-component system sensor histidine kinase PmrB;
603-885 5.32e-14

two-component system sensor histidine kinase PmrB;


Pssm-ID: 236751 [Multi-domain]  Cd Length: 356  Bit Score: 74.62  E-value: 5.32e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  603 QLQPIATPSQTLAVLAIEPSyLRQLLIpeqqrllqtftglianaleRLQLSrraesakLDTEReqlrnsLLAA-LSHDLR 681
Cdd:PRK10755 103 NLTPIAIHSSTLEIEAVTSA-LNQLVS-------------------RLTST-------LDQER------LFTAdVAHELR 149
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  682 TPLtvlfgqAEI-LMLDLSAEGspHTKQVNQIRQQILSTSRLVNNLLDMARIQ---SGGIQLNLEWqsLEEIV---GSTL 754
Cdd:PRK10755 150 TPL------AGIrLHLELLEKQ--HHIDVAPLIARLDQMMHTVEQLLQLARAGqsfSSGHYQTVKL--LEDVIlpsQDEL 219
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  755 RSLEYALNRHPVAVSLPSDLLLHCDASLLERVFINLLENAIKYTDEQIPLGIKATTEKNQIHIEVWDAGKGIPPEQEQLI 834
Cdd:PRK10755 220 SEMLEQRQQTLLLPESAADITVQGDATLLRLLLRNLVENAHRYSPEGSTITIKLSQEDGGAVLAVEDEGPGIDESKCGEL 299
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 37525371  835 FDKFSRArkESAIPGVGLGLAICRAIIEIHQGKIWASN-NEKGGASFHFVLP 885
Cdd:PRK10755 300 SKAFVRM--DSRYGGIGLGLSIVSRITQLHHGQFFLQNrQERSGTRAWVWLP 349
HATPase_BvrS-ChvG-like cd16953
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
783-885 7.22e-14

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.


Pssm-ID: 340429 [Multi-domain]  Cd Length: 110  Bit Score: 68.37  E-value: 7.22e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 783 LERVFINLLENAIKYT-DEQIPLGIKATTEKNQIHIEVWDAGKGIPPEQEQLIFDKFSRARKESAIPGV--GLGLAICRA 859
Cdd:cd16953   1 LGQVLRNLIGNAISFSpPDTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERPANEAFGQhsGLGLSISRQ 80
                        90       100       110
                ....*....|....*....|....*....|
gi 37525371 860 IIEIHQGKIWASNNEKG----GASFHFVLP 885
Cdd:cd16953  81 IIEAHGGISVAENHNQPgqviGARFTVQLP 110
HATPase_CreC-like cd16945
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
779-880 7.95e-14

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.


Pssm-ID: 340421 [Multi-domain]  Cd Length: 106  Bit Score: 68.26  E-value: 7.95e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 779 DASLLERVFINLLENAIKYTDEQIPLGIKATTEKNQIHIEVWDAGKGIPPEQEQLIFDKF-SRARKESAIPGVGLGLAIC 857
Cdd:cd16945   1 DPFLLRQAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFySLPRPHSGQKSTGLGLAFV 80
                        90       100
                ....*....|....*....|...
gi 37525371 858 RAIIEIHQGKIWASNNEKGGASF 880
Cdd:cd16945  81 QEVAQLHGGRITLRNRPDGVLAF 103
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
663-897 8.76e-14

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 75.36  E-value: 8.76e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  663 TEREQLRNSL----------LAALSHDLRTPLTVLFGQAEILM-LDLSAEgspHTKQVNQIRQQILSTSRLVNNLLDMAR 731
Cdd:PRK11091 267 TERKRYQDALekasrdkttfISTISHELRTPLNGIVGLSRILLdTELTAE---QRKYLKTIHVSAITLGNIFNDIIDMDK 343
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  732 IQSGGIQLNLEWQSLEEIVG-----STL----RSLEYALNRHPvavSLPSDLLLhcDASLLERVFINLLENAIKYTDE-Q 801
Cdd:PRK11091 344 MERRKLQLDNQPIDFTDFLAdlenlSGLqaeqKGLRFDLEPLL---PLPHKVIT--DGTRLRQILWNLISNAVKFTQQgG 418
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  802 IPLGIKATtEKNQIHIEVWDAGKGIPPEQEQLIFDKF----SRARKESAIpGVGLGLAICRAIIEIHQGKIWASNNEKGG 877
Cdd:PRK11091 419 VTVRVRYE-EGDMLTFEVEDSGIGIPEDELDKIFAMYyqvkDSHGGKPAT-GTGIGLAVSKRLAQAMGGDITVTSEEGKG 496
                        250       260
                 ....*....|....*....|
gi 37525371  878 ASFHFVLPLEKPPEIITEEM 897
Cdd:PRK11091 497 SCFTLTIHAPAVAEEVEDAF 516
HATPase_SpaK_NisK-like cd16975
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
779-878 5.99e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.


Pssm-ID: 340434 [Multi-domain]  Cd Length: 107  Bit Score: 65.95  E-value: 5.99e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 779 DASLLERVFINLLENAIKYTDEQIPLGIKATTEKNQIHIEVWDAGKGIPPEQEQLIFDKFSRARKESAIPG-VGLGLAIC 857
Cdd:cd16975   1 DTLLLSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRSGGhYGMGLYIA 80
                        90       100
                ....*....|....*....|.
gi 37525371 858 RAIIEIHQGKIWASNNEKGGA 878
Cdd:cd16975  81 KNLVEKHGGSLIIENSQKGGA 101
HATPase_YcbM-like cd16947
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
766-875 1.66e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).


Pssm-ID: 340423 [Multi-domain]  Cd Length: 125  Bit Score: 65.23  E-value: 1.66e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 766 VAVSLP-SDLLLHCDASLLERVFINLLENAIKYTDEQIPLGIKATTEKNQIHIEVWDAGKGIPPEQEQLIFDKFSRA--R 842
Cdd:cd16947   3 VEINIPdRPIYANANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLedS 82
                        90       100       110
                ....*....|....*....|....*....|....*
gi 37525371 843 KESAIPGVGLGLAICRAIIEIHQGKIWASN--NEK 875
Cdd:cd16947  83 RNSAKQGNGLGLTITKRLAESMGGSIYVNSkpYEK 117
PRK11107 PRK11107
hybrid sensory histidine kinase BarA; Provisional
673-896 1.13e-11

hybrid sensory histidine kinase BarA; Provisional


Pssm-ID: 236848 [Multi-domain]  Cd Length: 919  Bit Score: 68.72  E-value: 1.13e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  673 LAALSHDLRTPLTVLFGQAEILMldlsaEGSPHTKQVNQIRQQILSTSRL---VNNLLDMARIQSGGIQL-NLEWQ---S 745
Cdd:PRK11107 297 LANMSHELRTPLNGVIGFTRQTL-----KTPLTPTQRDYLQTIERSANNLlaiINDILDFSKLEAGKLVLeNIPFSlreT 371
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  746 LEEIVgsTLRS-------LEYALNRHPvavSLPSDLLlhCDASLLERVFINLLENAIKYTDE---QIPLGIKA-TTEKNQ 814
Cdd:PRK11107 372 LDEVV--TLLAhsahekgLELTLNIDP---DVPDNVI--GDPLRLQQIITNLVGNAIKFTESgniDILVELRAlSNTKVQ 444
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  815 IHIEVWDAGKGIPPEQEQLIFDKFSRArkESAIP----GVGLGLAICRAIIEIHQGKIWASNNEKGGASFHFVLPLEKPP 890
Cdd:PRK11107 445 LEVQIRDTGIGISERQQSQLFQAFRQA--DASISrrhgGTGLGLVITQKLVNEMGGDISFHSQPNRGSTFWFHLPLDLNP 522

                 ....*.
gi 37525371  891 EIITEE 896
Cdd:PRK11107 523 NPIIDG 528
HisKA smart00388
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ...
669-735 1.39e-11

His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.


Pssm-ID: 214644 [Multi-domain]  Cd Length: 66  Bit Score: 60.66  E-value: 1.39e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 37525371    669 RNSLLAALSHDLRTPLTVLFGQAEILmldLSAEGSPHTKQ-VNQIRQQILSTSRLVNNLLDMARIQSG 735
Cdd:smart00388   2 KREFLANLSHELRTPLTAIRGYLELL---LDTELSEEQREyLETILREAERLLRLINDLLDLSRIEAG 66
HisKA pfam00512
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ...
669-735 1.74e-11

His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.


Pssm-ID: 459839 [Multi-domain]  Cd Length: 66  Bit Score: 60.30  E-value: 1.74e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 37525371   669 RNSLLAALSHDLRTPLTVLFGQAEILMLDLSAEgsPHTKQVNQIRQQILSTSRLVNNLLDMARIQSG 735
Cdd:pfam00512   2 KSEFLANLSHELRTPLTAIRGYLELLRDEKLDE--EQREYLETILRSAERLLRLINDLLDLSRIEAG 66
HisKA cd00082
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ...
666-731 2.02e-11

Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.


Pssm-ID: 119399 [Multi-domain]  Cd Length: 65  Bit Score: 59.92  E-value: 2.02e-11
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 37525371 666 EQLRNSLLAALSHDLRTPLTVLFGQAEiLMLDLSAEGSPHTKQVNQIRQQILSTSRLVNNLLDMAR 731
Cdd:cd00082   1 LQAKGEFLANVSHELRTPLTAIRGALE-LLEEELLDDEEQREYLERIREEAERLLRLINDLLDLSR 65
COG4192 COG4192
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...
634-877 2.20e-11

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];


Pssm-ID: 443346 [Multi-domain]  Cd Length: 640  Bit Score: 67.40  E-value: 2.20e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 634 RLLQTFTGLI----ANALERLQLSRRAESAKLDTEREQLRNSLLAA-------LSHDLRTPLTVLfgQAEILMLDLSAEG 702
Cdd:COG4192 387 RLLRVFRDQAiektQELETEIEERKRIEKNLRQTQDELIQAAKMAVvgqtmtsLAHELNQPLNAM--SMYLFSAKKALEQ 464
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 703 SPHTK---QVNQIRQQILSTSRLVNNLLDMARIQSGGIQLnlewQSLEEIVGSTLRSLEYALNRHPVAVSLPSDLLLHCD 779
Cdd:COG4192 465 ENYAQlptSLDKIEGLIERMDKIIKSLRQFSRKSDTPLQP----VDLRQVIEQAWELVESRAKPQQITLHIPDDLMVQGD 540
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 780 ASLLERVFINLLENAIKYTDEQIPLGIKATTEKNQIHIEVWDAGKGIPpeqeqlIFDKFSRARKESAIPGVGLGLAICRA 859
Cdd:COG4192 541 QVLLEQVLVNLLVNALDAVATQPQISVDLLSNAENLRVAISDNGNGWP------LVDKLFTPFTTTKEVGLGLGLSICRS 614
                       250
                ....*....|....*....
gi 37525371 860 IIEIHQGKIW-ASNNEKGG 877
Cdd:COG4192 615 IMQQFGGDLYlASTLERGA 633
PRK10841 PRK10841
two-component system sensor histidine kinase RcsC;
673-886 2.81e-11

two-component system sensor histidine kinase RcsC;


Pssm-ID: 182772 [Multi-domain]  Cd Length: 924  Bit Score: 67.69  E-value: 2.81e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  673 LAALSHDLRTPLTVLFGQAEILmldlsaegspHTKQVNQIRQQILST----SRL----VNNLLDMARIQSGgiQLNLEWQ 744
Cdd:PRK10841 451 LATVSHELRTPLYGIIGNLDLL----------QTKELPKGVDRLVTAmnnsSSLllkiISDILDFSKIESE--QLKIEPR 518
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  745 --SLEEIVGstlrsleyalnrHPVAVSLP----SDLLLHC------------DASLLERVFINLLENAIKYTDeqipLG- 805
Cdd:PRK10841 519 efSPREVIN------------HITANYLPlvvkKRLGLYCfiepdvpvalngDPMRLQQVISNLLSNAIKFTD----TGc 582
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  806 --IKATTEKNQIHIEVWDAGKGIPP-EQEQLiFDKFSRA--RKESAIPGVGLGLAICRAIIEIHQGKIwASNNEKG-GAS 879
Cdd:PRK10841 583 ivLHVRVDGDYLSFRVRDTGVGIPAkEVVRL-FDPFFQVgtGVQRNFQGTGLGLAICEKLINMMDGDI-SVDSEPGmGSQ 660

                 ....*..
gi 37525371  880 FHFVLPL 886
Cdd:PRK10841 661 FTIRIPL 667
HATPase_EcPhoR-like cd16952
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
783-885 4.07e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.


Pssm-ID: 340428 [Multi-domain]  Cd Length: 108  Bit Score: 60.68  E-value: 4.07e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 783 LERVFINLLENAIKYTDEQIPLGIKATTEKNQIHIEVWDAGKGIPPEQEQLIFDKFSRARKESA--IPGVGLGLAICRAI 860
Cdd:cd16952   1 LRSAFSNLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCrnTGGTGLGLAIVKHV 80
                        90       100
                ....*....|....*....|....*
gi 37525371 861 IEIHQGKIWASNNEKGGASFHFVLP 885
Cdd:cd16952  81 MSRHDARLLIASELGKGSRFTCLFP 105
HATPase_NtrY-like cd16944
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
779-885 5.11e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.


Pssm-ID: 340420 [Multi-domain]  Cd Length: 108  Bit Score: 60.24  E-value: 5.11e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 779 DASLLERVFINLLENAIKYTdEQIPLG-----IKATTEK-NQIHIEVWDAGKGIPPEQEQLIFDKFSRARKEsaipGVGL 852
Cdd:cd16944   1 DTTQISQVLTNILKNAAEAI-EGRPSDvgevrIRVEADQdGRIVLIVCDNGKGFPREMRHRATEPYVTTRPK----GTGL 75
                        90       100       110
                ....*....|....*....|....*....|...
gi 37525371 853 GLAICRAIIEIHQGKIWASNNEKGGASFHFVLP 885
Cdd:cd16944  76 GLAIVKKIMEEHGGRISLSNREAGGACIRIILP 108
HATPase_HupT_MifS-like cd16976
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
783-884 2.44e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.


Pssm-ID: 340435 [Multi-domain]  Cd Length: 102  Bit Score: 58.24  E-value: 2.44e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 783 LERVFINLLENAI-KYTDEQIP-LGIKATTEKNQIHIEVWDAGKGIPPEQEQLIFDKFSRARKESAipGVGLGLAICRAI 860
Cdd:cd16976   1 IQQVLMNLLQNALdAMGKVENPrIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTKPVGK--GTGLGLSISYGI 78
                        90       100
                ....*....|....*....|....
gi 37525371 861 IEIHQGKIWASNNEKGGASFHFVL 884
Cdd:cd16976  79 VEEHGGRLSVANEEGAGARFTFDL 102
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
789-885 2.52e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 58.07  E-value: 2.52e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 789 NLLENAIKYT-DEQIPLG---IKATTEKNQIHIEVWDAGKGIPPEQEQLIFDK-FS-RARKESaipgvGLGLAICRAIIE 862
Cdd:cd16915   7 NLIDNALDALaATGAPNKqveVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERgVStKGQGER-----GIGLALVRQSVE 81
                        90       100
                ....*....|....*....|...
gi 37525371 863 IHQGKIWASNNEKGGASFHFVLP 885
Cdd:cd16915  82 RLGGSITVESEPGGGTTFSIRIP 104
HATPase_BceS-YxdK-YvcQ-like cd16948
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
779-885 7.32e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.


Pssm-ID: 340424 [Multi-domain]  Cd Length: 109  Bit Score: 54.21  E-value: 7.32e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 779 DASLLERVFINLLENAIKYTDEQIPLGIKATTEKNQIHIEVWDAGKGIPPEQEQLIFDKF---SRARKESAIPGVGLGLA 855
Cdd:cd16948   2 DAKWLSFIIGQIVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGftgENGRNFQESTGMGLYLV 81
                        90       100       110
                ....*....|....*....|....*....|
gi 37525371 856 icRAIIEIHQGKIWASNNEKGGASFHFVLP 885
Cdd:cd16948  82 --KKLCDKLGHKIDVESEVGEGTTFTITFP 109
GAF_3 pfam13492
GAF domain;
531-649 7.89e-09

GAF domain;


Pssm-ID: 433253 [Multi-domain]  Cd Length: 129  Bit Score: 54.68  E-value: 7.89e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371   531 NEEDIARTSYHFLTNGFQAKTG-LFLPNDDGNLYQLTTNNGGH------MLIDDAIAKWSFDKNLPA----GAGTDTLPS 599
Cdd:pfam13492   1 SLDEILEALLKLLVRLLGAERAaVYLLDEDGNKLQVAAGYDGEpdpsesLDADSPLARRALSSGEPIsglgSAGEDGLPD 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 37525371   600 VPYQLQPIATPSQTLAVLAIEPSYLRQLLiPEQQRLLQTFTGLIANALER 649
Cdd:pfam13492  81 GPALVVPLVAGRRVIGVLALASSKPRAFD-AEDLRLLESLAAQIATAIEN 129
PRK13837 PRK13837
two-component system VirA-like sensor kinase;
611-891 1.06e-08

two-component system VirA-like sensor kinase;


Pssm-ID: 237526 [Multi-domain]  Cd Length: 828  Bit Score: 58.92  E-value: 1.06e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  611 SQTLAVLAIEpsYLRQLLIP--EQQRLLQTFTGLIANALE--RLQLSRRAESAKLD-TEREQLRNSLLAALSHDLRTPLT 685
Cdd:PRK13837 389 DRIVALLGLG--RQRYGLRPpaGELQLLELALDCLAHAIErrRLETERDALERRLEhARRLEAVGTLASGIAHNFNNILG 466
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  686 VLFGQAEIlMLDLSAEGSPHTKQVNQIRQQILSTSRLVNNLLDMARIQSGgiqlNLEWQSLEEIVGSTLRSLEYALNRHp 765
Cdd:PRK13837 467 AILGYAEM-ALNKLARHSRAARYIDEIISAGARARLIIDQILAFGRKGER----NTKPFDLSELVTEIAPLLRVSLPPG- 540
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  766 VAVSL---PSDLLLHCDASLLERVFINLLENAIKYTDE--QIPLGIKA---TTEKNQIH----------IEVWDAGKGIP 827
Cdd:PRK13837 541 VELDFdqdQEPAVVEGNPAELQQVLMNLCSNAAQAMDGagRVDISLSRaklRAPKVLSHgvlppgryvlLRVSDTGAGID 620
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 37525371  828 PEQEQLIFDKF--SRARkesaipGVGLGLAICRAIIEIHQGKIWASNNEKGGASFHFVLPLEKPPE 891
Cdd:PRK13837 621 EAVLPHIFEPFftTRAG------GTGLGLATVHGIVSAHAGYIDVQSTVGRGTRFDVYLPPSSKVP 680
HATPase_Glnl-NtrB-like cd16918
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
783-868 2.46e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).


Pssm-ID: 340395 [Multi-domain]  Cd Length: 109  Bit Score: 52.79  E-value: 2.46e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 783 LERVFINLLENAIK-------------YTDEQIPLGikATTEKNQIHIEVWDAGKGIPPEQEQLIFDKFSRARKEsaipG 849
Cdd:cd16918   1 LIQVFLNLVRNAAQalagsggeiilrtRTQRQVTLG--HPRHRLALRVSVIDNGPGIPPDLQDTIFYPMVSGREN----G 74
                        90
                ....*....|....*....
gi 37525371 850 VGLGLAICRAIIEIHQGKI 868
Cdd:cd16918  75 TGLGLAIAQNIVSQHGGVI 93
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
790-888 1.62e-07

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 54.64  E-value: 1.62e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 790 LLENAIKY----TDEQIPLGIKATTEKNQIHIEVWDAGKGIPPEQEQLIFDKFSRARKESaipgvGLGLAICRAIIEIHQ 865
Cdd:COG2972 344 LVENAIEHgiepKEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEELSSKGEGR-----GIGLRNVRERLKLYY 418
                        90       100
                ....*....|....*....|....*.
gi 37525371 866 GK---IWASNNEKGGASFHFVLPLEK 888
Cdd:COG2972 419 GEeygLEIESEPGEGTTVTIRIPLEE 444
glnL PRK11073
nitrogen regulation protein NR(II);
657-886 9.10e-07

nitrogen regulation protein NR(II);


Pssm-ID: 182947 [Multi-domain]  Cd Length: 348  Bit Score: 52.01  E-value: 9.10e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  657 ESAKLDTER----EQLRNS-------LLAALSHDLRTPLTVLFGQAEILMLDLSaegSPHTKQVNQIrqqILSTSRLVNN 725
Cdd:PRK11073 107 EMAPMDNQRrlsqEQLQHAqqvaardLVRGLAHEIKNPLGGLRGAAQLLSKALP---DPALTEYTKV---IIEQADRLRN 180
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  726 LLDmaRI---QSGGIQlnlEWQSLEEIVG--STLRSLEYALNrhpVAV------SLPSdlLLHcDASLLERVFINLLENA 794
Cdd:PRK11073 181 LVD--RLlgpQRPGTH---VTESIHKVAErvVQLVSLELPDN---VRLirdydpSLPE--LAH-DPDQIEQVLLNIVRNA 249
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  795 IKYTDEQ---IPLGIKaTTEKNQIH---------IEVWDAGKGIPPEQEQLIFDKFSRARKEsaipGVGLGLAICRAIIE 862
Cdd:PRK11073 250 LQALGPEggtITLRTR-TAFQLTLHgeryrlaarIDIEDNGPGIPPHLQDTLFYPMVSGREG----GTGLGLSIARNLID 324
                        250       260
                 ....*....|....*....|....*...
gi 37525371  863 IHQGKI----WASNNEkggasFHFVLPL 886
Cdd:PRK11073 325 QHSGKIeftsWPGHTE-----FSVYLPI 347
PRK10618 PRK10618
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
649-841 8.87e-05

phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional


Pssm-ID: 236726 [Multi-domain]  Cd Length: 894  Bit Score: 46.46  E-value: 8.87e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  649 RLQLSRRaESAKldteREQLRNSLLAALSHDLRTPLTVLFGQAEILMLDLSAEGspHTKQVNQIRQQILSTSRLVNNLLD 728
Cdd:PRK10618 435 KLQQAQR-EYEK----NQQARKAFLQNIGDELKQPLQSLAQLAAQLRQTSDEEQ--QQPELDQLAEQSDVLVRLVDNIQL 507
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  729 MARIQSGGIQLNLEWQSLEEIVGSTLRSLEYALNRHP----VAVSLPSDLLLHCDASLLERVFINLLENAIKYTD-EQIP 803
Cdd:PRK10618 508 LNMLETQDWKPEQELFSLQDLIDEVLPEVLPAIKRKGlqllIHNHLKAEQLRIGDRDALRKILLLLLNYAITTTAyGKIT 587
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 37525371  804 LGIKATTE-KNQIHIEVWDAGKGIPP-EQEQLIF--------DKFSRA 841
Cdd:PRK10618 588 LEVDQDESsPDRLTIRILDTGAGVSIkELDNLHFpflnqtqgDRYGKA 635
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
790-860 1.16e-04

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 42.59  E-value: 1.16e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 37525371 790 LLENAIKYTDEQIPLG---IKATTEKNQIHIEVWDAGKGIPPEQeqlifdkfsRARKESAIPGVGLGLAICRAI 860
Cdd:COG2172  42 AVTNAVRHAYGGDPDGpveVELELDPDGLEIEVRDEGPGFDPED---------LPDPYSTLAEGGRGLFLIRRL 106
LytS COG3275
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];
787-889 1.33e-04

Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];


Pssm-ID: 442506 [Multi-domain]  Cd Length: 352  Bit Score: 45.24  E-value: 1.33e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 787 FINLLENAIKY----TDEQIPLGIKATTEKNQIHIEVWDAGKGIPPEQEQlifdkfsrarkesaiPGVGLGLAICRAIIE 862
Cdd:COG3275 258 LQPLVENAIKHgissKEGGGTISISIEVEGDRLVIEVENNGVGIQPKKKK---------------KGSGIGLKNVRERLE 322
                        90       100       110
                ....*....|....*....|....*....|
gi 37525371 863 IHQGKIWA---SNNEKGGASFHFVLPLEKP 889
Cdd:COG3275 323 LLYGDKYSleiESTDGGGTKVTLKIPLKKE 352
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
635-889 2.37e-04

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 43.84  E-value: 2.37e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 635 LLQTFTGLIANALERLQLSRRAESAKLDTEREQLRNSLLAALsHDlrTPLTVLFG---QAEILMLDLSAEGSPHTKQVNQ 711
Cdd:COG4585  20 LLLALVLLRARRAERAAELERELAARAEEAREEERRRIAREL-HD--GVGQSLSAiklQLEAARRLLDADPEAAREELEE 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 712 IRQQILSTSRLVNNLLDMARiQSGGIQLNLEwQSLEEIVGSTLRS--LEYALNRHPVAVSLPSDLLLHcdaslLERVFIN 789
Cdd:COG4585  97 IRELAREALAELRRLVRGLR-PPALDDLGLA-AALEELAERLLRAagIRVELDVDGDPDRLPPEVELA-----LYRIVQE 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 790 LLENAIKYTDEQiPLGIKATTEKNQIHIEVWDAGKGIPPEqeqlifdkfsrarkesAIPGVGLGLAICRAIIEIHQGKIW 869
Cdd:COG4585 170 ALTNALKHAGAT-RVTVTLEVDDGELTLTVRDDGVGFDPE----------------AAPGGGLGLRGMRERAEALGGTLT 232
                       250       260
                ....*....|....*....|
gi 37525371 870 ASNNEKGGASFHFVLPLEKP 889
Cdd:COG4585 233 IGSAPGGGTRVRATLPLAAA 252
PRK11086 PRK11086
sensory histidine kinase DcuS; Provisional
789-868 1.61e-03

sensory histidine kinase DcuS; Provisional


Pssm-ID: 236839 [Multi-domain]  Cd Length: 542  Bit Score: 42.21  E-value: 1.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371  789 NLLENAIKYTDEQIPLGIKATT--EKNQIHIEVWDAGKGIPPEQEQLIFDK-FSrarkeSAIPGVGLGLAICRAIIEIHQ 865
Cdd:PRK11086 440 NLIENALEAVGGEEGGEISVSLhyRNGWLHCEVSDDGPGIAPDEIDAIFDKgYS-----TKGSNRGVGLYLVKQSVENLG 514

                 ...
gi 37525371  866 GKI 868
Cdd:PRK11086 515 GSI 517
HATPase_PDK-like cd16929
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ...
781-868 1.96e-03

Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.


Pssm-ID: 340406 [Multi-domain]  Cd Length: 169  Bit Score: 40.02  E-value: 1.96e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 781 SLLERVFINLLENAIKYT-------DEQIPlGIKATTEKNQIH--IEVWDAGKGIPPEQEQLIFD-KFSRARKESAIP-- 848
Cdd:cd16929  42 SHLYYILFELLKNAMRATveshgddSDDLP-PIKVTVAKGDEDltIKISDRGGGIPREDLARLFSyMYSTAPQPSLDDfs 120
                        90       100       110
                ....*....|....*....|....*....|..
gi 37525371 849 ------------GVGLGLAICRAIIEIHQGKI 868
Cdd:cd16929 121 dlisgtqpsplaGFGYGLPMSRLYAEYFGGDL 152
HATPase_RsbW-like cd16936
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ...
790-860 2.41e-03

Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.


Pssm-ID: 340413 [Multi-domain]  Cd Length: 91  Bit Score: 38.02  E-value: 2.41e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 37525371 790 LLENAIKYT---DEQIPLGIKATTEKNQIHIEVWDAGKGIPPEQeqlifdkfsRARKESAIPGVGLGLAICRAI 860
Cdd:cd16936   8 AVTNAVRHAyrhDGPGPVRLELDLDPDRLRVEVTDSGPGFDPLR---------PADPDAGLREGGRGLALIRAL 72
HATPase_LytS-like cd16957
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
790-885 2.83e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.


Pssm-ID: 340433 [Multi-domain]  Cd Length: 106  Bit Score: 38.18  E-value: 2.83e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37525371 790 LLENAIKY------TDEQIPLGIKATTEKnqIHIEVWDAGKGIPPEQEQLIfDKFSRARKEsaipGVGLGLA-ICRAIIE 862
Cdd:cd16957   9 LVENAIRHafpkrkENNEVRVVVKKDQHK--VHVSVSDNGQGIPEERLDLL-GKTTVTSEK----GTGTALEnLNRRLIG 81
                        90       100
                ....*....|....*....|....*
gi 37525371 863 IH--QGKIWASNNEKGGASFHFVLP 885
Cdd:cd16957  82 LFgsEACLHIESEVHGGTEVWFVIP 106
 
Blast search parameters
Data Source: Live blast search RID = SRZ5GSKH016
User Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01   Maximum number of hits: 500

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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