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Conserved domains on  [gi|153792259|ref|NP_872337|]
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zinc finger protein 778 isoform 2 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

CATH:  3.30.160.60|1.10.287.1360
Gene Ontology:  GO:0003700|GO:0005515|GO:0008270|GO:0003677|GO:0006355|GO:0001217
PubMed:  22803940|8183940|2023909|8183939|10748030|27867147|28765213|11361095|30718982|10940247
SCOP:  4003583|4002243

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 42-81 3.94e-25

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 97.93  E-value: 3.94e-25
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 153792259   42 VTFDDVAVDFTQEEWTLLDPSQRDLYRDVMLENYENLASV 81
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
352-719 1.35e-12

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 70.49  E-value: 1.35e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792259 352 LNEHGKTHTREKPFACVV--CGKYFRNSSCLNNHVRIHTGIKPYTCSY-CGKAFTVRCGLTRHVRTHTGEKPYTCKDCGK 428
Cdd:COG5048   49 LTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKsLPLSNSKASSSSLSSSSSNSNDNNLLSSHSL 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792259 429 AFCTSSGLTEHVRTHTGEKPYECKDCGKSFTVSS----------------------SLTEHARIHTGEKPYECKQCGKAF 486
Cdd:COG5048  129 PPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqsnslhpplpanslskdpssnlSLLISSNVSTSIPSSSENSPLSSS 208

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792259 487 TGRSGLTKHMRTHTGEKPYECKDCGKAYNRVYLLNEHVKTHteeKPFICTVCRKSFRNSSCLNKHIQIH----------T 556
Cdd:COG5048  209 YSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLS---SSDSSSSASESPRSSLPTASSQSSSpnesdsssekG 285

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792259 557 GIKPYECKDCGKTFTVSSSLTEHIRT--HTGE--KPYECKV--CGKAFTTSSHLIVHIRTHTGEKPYICK--ECGKAFAS 628
Cdd:COG5048  286 FSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSP 365

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792259 629 SSH-----LIEHRRTHTGEKPYIC--NECGKAFRASSHLHKHGRIHTGQKP--YKCKECGKAYNRFYLLKEHLKTYTEEQ 699
Cdd:COG5048  366 LLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHA 445

                        410       420
                 ....*....|....*....|
gi 153792259 700 VFVCKDCGKSFKNSSCLNHH 719
Cdd:COG5048  446 PLLCSILKSFRRDLDLSNHG 465
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 42-81 3.94e-25

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 97.93  E-value: 3.94e-25
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 153792259   42 VTFDDVAVDFTQEEWTLLDPSQRDLYRDVMLENYENLASV 81
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB smart00349
krueppel associated box;
42-82 1.83e-24

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 96.89  E-value: 1.83e-24
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 153792259    42 VTFDDVAVDFTQEEWTLLDPSQRDLYRDVMLENYENLASVE 82
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLG 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 42-80 4.45e-22

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 89.15  E-value: 4.45e-22
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 153792259  42 VTFDDVAVDFTQEEWTLLDPSQRDLYRDVMLENYENLAS 80
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
352-719 1.35e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 70.49  E-value: 1.35e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792259 352 LNEHGKTHTREKPFACVV--CGKYFRNSSCLNNHVRIHTGIKPYTCSY-CGKAFTVRCGLTRHVRTHTGEKPYTCKDCGK 428
Cdd:COG5048   49 LTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKsLPLSNSKASSSSLSSSSSNSNDNNLLSSHSL 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792259 429 AFCTSSGLTEHVRTHTGEKPYECKDCGKSFTVSS----------------------SLTEHARIHTGEKPYECKQCGKAF 486
Cdd:COG5048  129 PPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqsnslhpplpanslskdpssnlSLLISSNVSTSIPSSSENSPLSSS 208

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792259 487 TGRSGLTKHMRTHTGEKPYECKDCGKAYNRVYLLNEHVKTHteeKPFICTVCRKSFRNSSCLNKHIQIH----------T 556
Cdd:COG5048  209 YSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLS---SSDSSSSASESPRSSLPTASSQSSSpnesdsssekG 285

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792259 557 GIKPYECKDCGKTFTVSSSLTEHIRT--HTGE--KPYECKV--CGKAFTTSSHLIVHIRTHTGEKPYICK--ECGKAFAS 628
Cdd:COG5048  286 FSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSP 365

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792259 629 SSH-----LIEHRRTHTGEKPYIC--NECGKAFRASSHLHKHGRIHTGQKP--YKCKECGKAYNRFYLLKEHLKTYTEEQ 699
Cdd:COG5048  366 LLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHA 445

                        410       420
                 ....*....|....*....|
gi 153792259 700 VFVCKDCGKSFKNSSCLNHH 719
Cdd:COG5048  446 PLLCSILKSFRRDLDLSNHG 465
zf-H2C2_2 pfam13465
Zinc-finger double domain;
575-600 1.33e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.33e-04
                          10        20
                  ....*....|....*....|....*.
gi 153792259  575 SLTEHIRTHTGEKPYECKVCGKAFTT 600
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
PHA00733 PHA00733
hypothetical protein
 544-608 4.17e-04

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 41.01  E-value: 4.17e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 153792259 544 NSSCLNKHIQIHTgIKPYECKDCGKTFTVSSSLTEHIRTHTGEKpyECKVCGKAFTTSSHLIVHI 608
Cdd:PHA00733  58 ESSYLYKLLTSKA-VSPYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDHV 119
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 42-81 3.94e-25

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 97.93  E-value: 3.94e-25
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 153792259   42 VTFDDVAVDFTQEEWTLLDPSQRDLYRDVMLENYENLASV 81
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB smart00349
krueppel associated box;
42-82 1.83e-24

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 96.89  E-value: 1.83e-24
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 153792259    42 VTFDDVAVDFTQEEWTLLDPSQRDLYRDVMLENYENLASVE 82
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLG 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 42-80 4.45e-22

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 89.15  E-value: 4.45e-22
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 153792259  42 VTFDDVAVDFTQEEWTLLDPSQRDLYRDVMLENYENLAS 80
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
352-719 1.35e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 70.49  E-value: 1.35e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792259 352 LNEHGKTHTREKPFACVV--CGKYFRNSSCLNNHVRIHTGIKPYTCSY-CGKAFTVRCGLTRHVRTHTGEKPYTCKDCGK 428
Cdd:COG5048   49 LTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKsLPLSNSKASSSSLSSSSSNSNDNNLLSSHSL 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792259 429 AFCTSSGLTEHVRTHTGEKPYECKDCGKSFTVSS----------------------SLTEHARIHTGEKPYECKQCGKAF 486
Cdd:COG5048  129 PPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqsnslhpplpanslskdpssnlSLLISSNVSTSIPSSSENSPLSSS 208

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792259 487 TGRSGLTKHMRTHTGEKPYECKDCGKAYNRVYLLNEHVKTHteeKPFICTVCRKSFRNSSCLNKHIQIH----------T 556
Cdd:COG5048  209 YSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLS---SSDSSSSASESPRSSLPTASSQSSSpnesdsssekG 285

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792259 557 GIKPYECKDCGKTFTVSSSLTEHIRT--HTGE--KPYECKV--CGKAFTTSSHLIVHIRTHTGEKPYICK--ECGKAFAS 628
Cdd:COG5048  286 FSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSP 365

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792259 629 SSH-----LIEHRRTHTGEKPYIC--NECGKAFRASSHLHKHGRIHTGQKP--YKCKECGKAYNRFYLLKEHLKTYTEEQ 699
Cdd:COG5048  366 LLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHA 445

                        410       420
                 ....*....|....*....|
gi 153792259 700 VFVCKDCGKSFKNSSCLNHH 719
Cdd:COG5048  446 PLLCSILKSFRRDLDLSNHG 465
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
391-676 2.84e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 69.72  E-value: 2.84e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792259 391 KPYTCSYCGKAFTVRCGLTRHVRTHTGEKPYTCKD--CGKAFCTSSGLTEHVRTHTGEKPYECKDCGKSFTVSSSLTEHA 468
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792259 469 RIHTGE-KPYECKQCGKAFTGRSGLTKHMRTHTGEKPYECKDCGKAY-------NRVYLLNEHVKTHTEEKPFICTVC-- 538
Cdd:COG5048  112 SSSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSvntpqsnSLHPPLPANSLSKDPSSNLSLLISsn 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792259 539 ------------------RKSFRNSSCLNKHIQIH------TGIKPYECKDCGKTFTVSSSLTEHIRTHtgekpYECKVC 594
Cdd:COG5048  192 vstsipsssensplsssySIPSSSSDQNLENSSSSlplttnSQLSPKSLLSQSPSSLSSSDSSSSASES-----PRSSLP 266

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792259 595 GKAFTTSSHLIVHIRTHTG-EKPYICKECGKAFASSSHLIEHRRT--HTGE--KPYICNE--CGKAFRASSHLHKHGRIH 667
Cdd:COG5048  267 TASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLH 346


                 ....*....
gi 153792259 668 TGQKPYKCK 676
Cdd:COG5048  347 TSISPAKEK 355
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
391-553 1.69e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.86  E-value: 1.69e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792259 391 KPYTCSYCGKAFTVRCGLTRHVRT--HTGE--KPYTC--KDCGKAFCTSSGLTEHVRTHTGEKPYECK--DCGKSFTVSS 462
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792259 463 -----SLTEHARIHTGEKPYEC--KQCGKAFTGRSGLTKHMRTHTGEKPYECKD--CGKAYNRVYLLNEHVKTHTEEKPF 533
Cdd:COG5048  368 nneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKNppCSKSFNRHYNLIPHKKIHTNHAPL 447

                        170       180
                 ....*....|....*....|
gi 153792259 534 ICTVCRKSFRNSSCLNKHIQ 553
Cdd:COG5048  448 LCSILKSFRRDLDLSNHGKD 467
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
475-729 2.51e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.38  E-value: 2.51e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792259 475 KPYECKQCGKAFTGRSGLTKHMRTHTGEKPYECKD--CGKAYNRVYLLNEHVKTHTEEKPFICTVCRKSFRNSSCLNK-H 551
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSlS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792259 552 IQIHTGIKPYECKDCGKTFTVSSSLTEHIRTHTGEKPYECKVCGKAFTTSS----------------------HLIVHIR 609
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqsnslhpplpanslskdpssnlSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792259 610 THTGEKPYICKECGKAFASSSHLIEHRRTHTGEKPYICNECG----------------------------------KAFR 655
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSqlspksllsqspsslsssdssssasesprsslptASSQ 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792259 656 ASSHLHKHGRIHTGQ-KPYKCKECGKAYNRFYLLKEHLKTY------TEEQVFVCKDCGKSFKNSSCLNHHTQIHTDEKP 728
Cdd:COG5048  272 SSSPNESDSSSEKGFsLPIKSKQCNISFSRSSPLTRHLRSVnhsgesLKPFSCPYSLCGKLFSRNDALKRHILLHTSISP 351


                 .
gi 153792259 729 F 729
Cdd:COG5048  352 A 352
zf-H2C2_2 pfam13465
Zinc-finger double domain;
575-600 1.33e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.33e-04
                          10        20
                  ....*....|....*....|....*.
gi 153792259  575 SLTEHIRTHTGEKPYECKVCGKAFTT 600
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
492-516 2.17e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 2.17e-04
                          10        20
                  ....*....|....*....|....*
gi 153792259  492 LTKHMRTHTGEKPYECKDCGKAYNR 516
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 473-552 3.09e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.94  E-value: 3.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792259 473 GEKPYECK--QCGKAFTGRSGLTKHMRT-HTGEKPYECKDCGKaynrvyllneHVKTHTEEKPFICTVCRKSFRNSSCLN 549
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHMLHgHQNQKLHENPSPEK----------MNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                 ...
gi 153792259 550 KHI 552
Cdd:COG5189  416 YHR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
408-430 3.18e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 3.18e-04
                          10        20
                  ....*....|....*....|...
gi 153792259  408 LTRHVRTHTGEKPYTCKDCGKAF 430
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
436-459 3.80e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.80e-04
                          10        20
                  ....*....|....*....|....
gi 153792259  436 LTEHVRTHTGEKPYECKDCGKSFT 459
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
PHA00733 PHA00733
hypothetical protein
 544-608 4.17e-04

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 41.01  E-value: 4.17e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 153792259 544 NSSCLNKHIQIHTgIKPYECKDCGKTFTVSSSLTEHIRTHTGEKpyECKVCGKAFTTSSHLIVHI 608
Cdd:PHA00733  58 ESSYLYKLLTSKA-VSPYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDHV 119
zf-H2C2_2 pfam13465
Zinc-finger double domain;
463-487 7.85e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 7.85e-04
                          10        20
                  ....*....|....*....|....*
gi 153792259  463 SLTEHARIHTGEKPYECKQCGKAFT 487
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 589-611 1.10e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.89  E-value: 1.10e-03
                          10        20
                  ....*....|....*....|...
gi 153792259  589 YECKVCGKAFTTSSHLIVHIRTH 611
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
380-403 1.99e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.99e-03
                          10        20
                  ....*....|....*....|....
gi 153792259  380 LNNHVRIHTGIKPYTCSYCGKAFT 403
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
603-628 2.98e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.98e-03
                          10        20
                  ....*....|....*....|....*.
gi 153792259  603 HLIVHIRTHTGEKPYICKECGKAFAS 628
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 561-583 3.09e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 3.09e-03
                          10        20
                  ....*....|....*....|...
gi 153792259  561 YECKDCGKTFTVSSSLTEHIRTH 583
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
548-571 5.07e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 5.07e-03
                          10        20
                  ....*....|....*....|....
gi 153792259  548 LNKHIQIHTGIKPYECKDCGKTFT 571
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 477-499 5.79e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 5.79e-03
                          10        20
                  ....*....|....*....|...
gi 153792259  477 YECKQCGKAFTGRSGLTKHMRTH 499
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
PHA00733 PHA00733
hypothetical protein
 588-635 7.72e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 37.16  E-value: 7.72e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 153792259 588 PYECKVCGKAFTTSSHLIVHIRTHTGEKpyICKECGKAFASSSHLIEH 635
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDH 118
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 617-639 7.92e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 7.92e-03
                          10        20
                  ....*....|....*....|...
gi 153792259  617 YICKECGKAFASSSHLIEHRRTH 639
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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