NCBI Conserved Domain Search

Conserved domains on [gi|30684565|ref|NP_851036|]

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zinc induced facilitator-like 1 [Arabidopsis thaliana]

Protein Classification

MFS transporter( domain architecture ID 13023689)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH: 1.20.1250.20

Gene Ontology: GO:0022857|GO:0055085|GO:0016020

PubMed: 26758938|26098515|26234418

SCOP: 3000310

TCDB: 2.A.1

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

MFS_SLC46_TetA_like

cd17330

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...

41-470

8.20e-72

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 231.31 E-value: 8.20e-72

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  41 VWIIVLCTALPISSLFPFLYFMIDDFNiakKEEDIGFYAGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVF 120
Cdd:cd17330   1 LFLVVFLDALGFGIVFPVLPFYVREFN---KLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVS 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 121 NTLFGLSLNFWMAIITRFCLGSFNGLLGPIKAYAMEIFRDEYQGLALSAVSTAWGIGLIIGPAIGGFLAQPakqypslfs 200
Cdd:cd17330  78 YVLLGLSRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTP--------- 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 201 qdsifgkFPFFLPCLAISVFAFLVTIVSSRIPetlhnhkfnddesydalkdlsddpesnkvaerngkssllnnWPLISSI 280
Cdd:cd17330 149 -------YGYALPFLVAAALALLNLVLVLFFL-----------------------------------------PPLRRLL 180

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 281 IVYCVFSLHDMAYTEIFSLWANSPrkyggLGYSTADVGSVLAFSGFGLLIFQLSLYSYAERLLGPIIVTRISGSLAMVVL 360
Cdd:cd17330 181 LVYFLIALAFAGLESVFSLFLKDR-----FGFSPSQIGLLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGL 255

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 361 SCYPLIAKLSGLALTVTVTSASVAksvlgtSAITGLFILQNKAVRQDQRGAANGIAMTAMSLFKAIGPAAAGIIFSwsek 440
Cdd:cd17330 256 LLLPFASSVPLLVLAAAILAFGTG------IVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYS---- 325

                       410       420       430
                ....*....|....*....|....*....|
gi 30684565 441 rqgaafLPGTQMVFFILNVVLALGVVLTFK 470
Cdd:cd17330 326 ------FLGPGVPFLLAAGLLLIALFLLSL 349

Name

Accession

Description

Interval

E-value

MFS_SLC46_TetA_like

cd17330

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...

41-470

8.20e-72

Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 231.31 E-value: 8.20e-72

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  41 VWIIVLCTALPISSLFPFLYFMIDDFNiakKEEDIGFYAGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVF 120
Cdd:cd17330   1 LFLVVFLDALGFGIVFPVLPFYVREFN---KLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVS 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 121 NTLFGLSLNFWMAIITRFCLGSFNGLLGPIKAYAMEIFRDEYQGLALSAVSTAWGIGLIIGPAIGGFLAQPakqypslfs 200
Cdd:cd17330  78 YVLLGLSRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTP--------- 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 201 qdsifgkFPFFLPCLAISVFAFLVTIVSSRIPetlhnhkfnddesydalkdlsddpesnkvaerngkssllnnWPLISSI 280
Cdd:cd17330 149 -------YGYALPFLVAAALALLNLVLVLFFL-----------------------------------------PPLRRLL 180

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 281 IVYCVFSLHDMAYTEIFSLWANSPrkyggLGYSTADVGSVLAFSGFGLLIFQLSLYSYAERLLGPIIVTRISGSLAMVVL 360
Cdd:cd17330 181 LVYFLIALAFAGLESVFSLFLKDR-----FGFSPSQIGLLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGL 255

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 361 SCYPLIAKLSGLALTVTVTSASVAksvlgtSAITGLFILQNKAVRQDQRGAANGIAMTAMSLFKAIGPAAAGIIFSwsek 440
Cdd:cd17330 256 LLLPFASSVPLLVLAAAILAFGTG------IVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYS---- 325

                       410       420       430
                ....*....|....*....|....*....|
gi 30684565 441 rqgaafLPGTQMVFFILNVVLALGVVLTFK 470
Cdd:cd17330 326 ------FLGPGVPFLLAAGLLLIALFLLSL 349

AraJ

COG2814

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];

38-422

2.34e-25

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];

Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 106.60 E-value: 2.34e-25

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  38 LFTVWIIVLCTALPISSLFPFLYFMIDDFNIAkkeediGFYAGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASV 117
Cdd:COG2814  12 LLALALGAFLSGLGIGIVLPALPLIAADLGAS------PAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLF 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 118 VVFNTLFGLSLNFWMAIITRFCLGSFNGLLGPIK-AYAMEIFRDEYQGLALSAVSTAWGIGLIIGPAIGGFLAQpakqyp 196
Cdd:COG2814  86 ALGSLLCALAPSLWLLLAARFLQGLGAGALFPAAlALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD------ 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 197 sLFSQDSIFgkfpfflpcLAISVFAFLVTIVSSR-IPETLHNHKFNDDESYdalkdlsddpesnkvaerngkSSLLNNWP 275
Cdd:COG2814 160 -LFGWRWVF---------LVNAVLALLALLLLLRlLPESRPAARARLRGSL---------------------RELLRRPR 208

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 276 LISSIIVYCVFSLHDMAYTEIFSLWANSPrkyggLGYSTADVGSVLAFSGFGLLIFQLSLYSYAERlLGPIIVTRISGSL 355
Cdd:COG2814 209 LLLLLLLAFLLGFGFFALFTYLPLYLQEV-----LGLSASAAGLLLALFGLGGVLGALLAGRLADR-FGRRRLLLIGLLL 282

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 30684565 356 AMVVLSCYPLIAKLSGLALTVTVTSASVAksvlgtSAITGLFILQNKAVRQDQRGAANGIAMTAMSL 422
Cdd:COG2814 283 LALGLLLLALAGSLWLLLLALFLLGFGFG------LLFPLLQALVAELAPPEARGRASGLYNSAFFL 343

MFS_1

pfam07690

Major Facilitator Superfamily;

41-428

1.32e-19

Major Facilitator Superfamily;

Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 89.78 E-value: 1.32e-19

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565    41 VWIIVLCTALPISSLFPFL-YFMIDDFNIAKkeedigFYAGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVV 119
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALpLLLAEDLGISP------TEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFAL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565   120 FNTLFGLSLNFWMAIITRFCLGSFNGLLGP-IKAYAMEIFRDEYQGLALSAVSTAWGIGLIIGPAIGGFLAqpakqypSL 198
Cdd:pfam07690  75 GLLLLLFASSLWLLLVLRVLQGLGAGALFPaALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLA-------SL 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565   199 FSQDSIFgkfpfflpclAISVFAFLVTIVSSRIPETLHNHKFNDDEsydalkdlsddpESNKVAERNGKSSLLNNWPLIS 278
Cdd:pfam07690 148 FGWRAAF----------LILAILSLLAAVLLLLPRPPPESKRPKPA------------EEARLSLIVAWKALLRDPVLWL 205

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565   279 SIIVYCVFSLhdmayteIFSLWANSPRKYGGLGYSTADVGSVLAFSGFGLLIFQLSLYSYAERlLGPIIVTRISGSLAMV 358
Cdd:pfam07690 206 LLALLLFGFA-------FFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDR-LGRRRRLLLALLLLIL 277

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565   359 VLSCYPLIaklSGLALTVTVTSASVAKSVLGTSAITGLFILQNKAVRQDQRGAANGIAMTAMSLFKAIGP 428
Cdd:pfam07690 278 AALGLLLL---SLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344

2_A_01_02

TIGR00880

Multidrug resistance protein;

85-234

3.17e-11

Multidrug resistance protein;

Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 61.13 E-value: 3.17e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565    85 SFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGSFNGLLGPI-KAYAMEIFRDEYQ 163
Cdd:TIGR00880   6 GYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAgAALIADIYPPEER 85

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 30684565   164 GLALSAVSTAWGIGLIIGPAIGGFLAQpAKQYPSLFsqdsifgkfpFFLPCLAISVFAFLVTIvssrIPET 234
Cdd:TIGR00880  86 GVALGLMSAGIALGPLLGPPLGGVLAQ-FLGWRAPF----------LFLAILALAAFILLAFL----LPET 141

PRK09874

multidrug efflux MFS transporter MdtG;

38-230

1.36e-09

multidrug efflux MFS transporter MdtG;

Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 59.93 E-value: 1.36e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565   38 LFTVWIIVLCTALPISSLFPFLYFMIDDFNIAKKEEdIGFYAGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASV 117
Cdd:PRK09874  16 LTVAWLGCFLTGAAFSLVMPFLPLYVEQLGVTGHSA-LNMWSGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSALGM 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  118 VVFNTLFGLSLNFWMAIITRFCLGSFNGLLGPIKAY-AMEIFRDEyQGLALSAVSTAWGIGLIIGPAIGGFLAQPakqyp 196
Cdd:PRK09874  95 GIVMVLMGLAQNIWQFLILRALLGLLGGFVPNANALiATQVPRNK-SGWALGTLSTGGVSGALLGPLAGGLLADS----- 168

                        170       180       190
                 ....*....|....*....|....*....|....
gi 30684565  197 slfsqdsiFGKFPFFLPCLAISVFAFLVTIVSSR 230
Cdd:PRK09874 169 --------YGLRPVFFITASVLFLCFLVTLFCIR 194

Name

Accession

Description

Interval

E-value

MFS_SLC46_TetA_like

cd17330

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...

41-470

8.20e-72

Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 231.31 E-value: 8.20e-72

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  41 VWIIVLCTALPISSLFPFLYFMIDDFNiakKEEDIGFYAGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVF 120
Cdd:cd17330   1 LFLVVFLDALGFGIVFPVLPFYVREFN---KLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVS 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 121 NTLFGLSLNFWMAIITRFCLGSFNGLLGPIKAYAMEIFRDEYQGLALSAVSTAWGIGLIIGPAIGGFLAQPakqypslfs 200
Cdd:cd17330  78 YVLLGLSRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTP--------- 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 201 qdsifgkFPFFLPCLAISVFAFLVTIVSSRIPetlhnhkfnddesydalkdlsddpesnkvaerngkssllnnWPLISSI 280
Cdd:cd17330 149 -------YGYALPFLVAAALALLNLVLVLFFL-----------------------------------------PPLRRLL 180

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 281 IVYCVFSLHDMAYTEIFSLWANSPrkyggLGYSTADVGSVLAFSGFGLLIFQLSLYSYAERLLGPIIVTRISGSLAMVVL 360
Cdd:cd17330 181 LVYFLIALAFAGLESVFSLFLKDR-----FGFSPSQIGLLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGL 255

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 361 SCYPLIAKLSGLALTVTVTSASVAksvlgtSAITGLFILQNKAVRQDQRGAANGIAMTAMSLFKAIGPAAAGIIFSwsek 440
Cdd:cd17330 256 LLLPFASSVPLLVLAAAILAFGTG------IVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYS---- 325

                       410       420       430
                ....*....|....*....|....*....|
gi 30684565 441 rqgaafLPGTQMVFFILNVVLALGVVLTFK 470
Cdd:cd17330 326 ------FLGPGVPFLLAAGLLLIALFLLSL 349

MFS_MdtG_SLC18_like

cd17325

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...

41-469

7.61e-29

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 116.91 E-value: 7.61e-29

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  41 VWIIVLCTALPISSLFPFLYFMIDDFNIAkkeediGFYAGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVF 120
Cdd:cd17325   1 LSLALFLDMLGYGIIIPILPLYAESLGAS------VAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVS 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 121 NTLFGLSLNFWMAIITRFCLGSFNGLLGPIK-AYAMEIFRDEYQGLALSAVSTAWGIGLIIGPAIGGFLAqpakqypslf 199
Cdd:cd17325  75 TLLFAFATSYWQLLLARFLQGLASAAVWPAAmALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLA---------- 144

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 200 sqDSIFGKFPFFLpCLAISVFAFLVTIVSSRIPETLHNHKFNDDESydalkdlsddpesnkvaERNGKSSLLNNWPLISS 279
Cdd:cd17325 145 --DALGYRAPFLV-CAALALLALVLALLLLPEPRPPPNKRAVSAAR-----------------LRSGLRLLLRDRRLLAL 204

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 280 IIVYCVFSLHDMAYTEIFSLWANSPrkyggLGYSTADVGSVLAFSGFGLLIFQLSLYSYAERlLGPIIVTRISGSLAMVV 359
Cdd:cd17325 205 FLAIFVLAFAFGALEPFLPLYAAEL-----GGLSPAQIGLLFGAQGLASALSQPPAGKLSDR-IGRKPLILIGLLLSAVA 278

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 360 LSCYPLIAKLSGLALTVTVTSASVAksvLGTSAITGLFIlqnKAVRQDQRGAANGIAMTAMSLFKAIGPAAAGIIFSWSe 439
Cdd:cd17325 279 LLLLPLATSFWLLLLLLALLGLGLG---LVFPATLALLA---DIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAF- 351

                       410       420       430
                ....*....|....*....|....*....|
gi 30684565 440 krqgaaflpGTQMVFFILNVVLALGVVLTF 469
Cdd:cd17325 352 ---------GFATPFLAAAALLLLAAVLFL 372

AraJ

COG2814

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];

38-422

2.34e-25

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];

Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 106.60 E-value: 2.34e-25

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  38 LFTVWIIVLCTALPISSLFPFLYFMIDDFNIAkkeediGFYAGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASV 117
Cdd:COG2814  12 LLALALGAFLSGLGIGIVLPALPLIAADLGAS------PAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLF 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 118 VVFNTLFGLSLNFWMAIITRFCLGSFNGLLGPIK-AYAMEIFRDEYQGLALSAVSTAWGIGLIIGPAIGGFLAQpakqyp 196
Cdd:COG2814  86 ALGSLLCALAPSLWLLLAARFLQGLGAGALFPAAlALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD------ 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 197 sLFSQDSIFgkfpfflpcLAISVFAFLVTIVSSR-IPETLHNHKFNDDESYdalkdlsddpesnkvaerngkSSLLNNWP 275
Cdd:COG2814 160 -LFGWRWVF---------LVNAVLALLALLLLLRlLPESRPAARARLRGSL---------------------RELLRRPR 208

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 276 LISSIIVYCVFSLHDMAYTEIFSLWANSPrkyggLGYSTADVGSVLAFSGFGLLIFQLSLYSYAERlLGPIIVTRISGSL 355
Cdd:COG2814 209 LLLLLLLAFLLGFGFFALFTYLPLYLQEV-----LGLSASAAGLLLALFGLGGVLGALLAGRLADR-FGRRRLLLIGLLL 282

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 30684565 356 AMVVLSCYPLIAKLSGLALTVTVTSASVAksvlgtSAITGLFILQNKAVRQDQRGAANGIAMTAMSL 422
Cdd:COG2814 283 LALGLLLLALAGSLWLLLLALFLLGFGFG------LLFPLLQALVAELAPPEARGRASGLYNSAFFL 343

MFS_1

pfam07690

Major Facilitator Superfamily;

41-428

1.32e-19

Major Facilitator Superfamily;

Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 89.78 E-value: 1.32e-19

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565    41 VWIIVLCTALPISSLFPFL-YFMIDDFNIAKkeedigFYAGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVV 119
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALpLLLAEDLGISP------TEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFAL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565   120 FNTLFGLSLNFWMAIITRFCLGSFNGLLGP-IKAYAMEIFRDEYQGLALSAVSTAWGIGLIIGPAIGGFLAqpakqypSL 198
Cdd:pfam07690  75 GLLLLLFASSLWLLLVLRVLQGLGAGALFPaALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLA-------SL 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565   199 FSQDSIFgkfpfflpclAISVFAFLVTIVSSRIPETLHNHKFNDDEsydalkdlsddpESNKVAERNGKSSLLNNWPLIS 278
Cdd:pfam07690 148 FGWRAAF----------LILAILSLLAAVLLLLPRPPPESKRPKPA------------EEARLSLIVAWKALLRDPVLWL 205

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565   279 SIIVYCVFSLhdmayteIFSLWANSPRKYGGLGYSTADVGSVLAFSGFGLLIFQLSLYSYAERlLGPIIVTRISGSLAMV 358
Cdd:pfam07690 206 LLALLLFGFA-------FFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDR-LGRRRRLLLALLLLIL 277

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565   359 VLSCYPLIaklSGLALTVTVTSASVAKSVLGTSAITGLFILQNKAVRQDQRGAANGIAMTAMSLFKAIGP 428
Cdd:pfam07690 278 AALGLLLL---SLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344

MFS

cd06174

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...

41-469

1.60e-19

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.

Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 90.18 E-value: 1.60e-19

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  41 VWIIVLCTALPISSLFPFLYFMIDDFNIAKkeedigFYAGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVF 120
Cdd:cd06174   1 LLLGFFLTGLARGLISPLLPALLQSFGLSA------SQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALG 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 121 NTLFGLSLNFWMAIITRFCLGSFNGLLGPI-KAYAMEIFRDEYQGLALSAVSTAWGIGLIIGPAIGGFLAQpakqypslf 199
Cdd:cd06174  75 ALLFAFAPSFWLLLLGRFLLGLGSGLIDPAvLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILAS--------- 145

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 200 sqdsiFGKFPFFLPCLAISVFAFLVTIVSSRIPETLHNHKFNDDESYDALKDLSDdpesnkvaerngKSSLLNNWPLISS 279
Cdd:cd06174 146 -----SLGFGWRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKL------------LKRVLKNPGLWLL 208

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 280 IIVYcvfSLHDMAYTEIFSLWANSPRKYGGLGYSTAdvGSVLAFSGFGLLIFQLSLYSYAERLLGPIIVTRISGSLAMVV 359
Cdd:cd06174 209 LLAI---FLVNLAYYSFSTLLPLFLLDLGGLSVAVA--GLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALG 283

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 360 LSCYPLIAKLSGLALTVTVTSASVAksvlgtSAITGLFILQNKAVRQDQRGAANGIAMTAMSLFKAIGPAAAGIIFSWSe 439
Cdd:cd06174 284 LALLLLAPSLLLLLLLLLLLGFGLG------GLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAAT- 356

                       410       420       430
                ....*....|....*....|....*....|
gi 30684565 440 krqgaaflPGTQMVFFILNVVLALGVVLTF 469
Cdd:cd06174 357 --------FGLTGAFLVLAVLLLLAAILLL 378

UhpC

COG2271

Sugar phosphate permease [Carbohydrate transport and metabolism];

27-190

4.47e-16

Sugar phosphate permease [Carbohydrate transport and metabolism];

Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 79.53 E-value: 4.47e-16

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  27 KRLRRGFPFWELFTVWIIVLCTALPISSLFPFLYFMIDDFNIAKKEedigfyAGFVGCSFMLGRAFTSVAWGLVADRYGR 106
Cdd:COG2271   1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQ------LGLLASAFFLGYALGQIPAGLLADRFGR 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 107 KPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGSFNGLLGPIKAYAM-EIFRDEYQGLALSAVSTAWGIGLIIGPAIG 185
Cdd:COG2271  75 RRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIaEWFPPKERGRALGIFNAGGPLGGALAPPLL 154


                ....*
gi 30684565 186 GFLAQ 190
Cdd:COG2271 155 GWLLA 159

ProP

COG0477

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...

26-190

1.13e-14

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];

Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 74.46 E-value: 1.13e-14

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  26 MKRLRRGFPFWELFTVWIIVLCTALP---ISSLFPFLYFMIDDFNIAkkeediGFYAGFVGCSFMLGRAFTSVAWGLVAD 102
Cdd:COG0477   1 MSSTDAAPTRRRRRALLALALGTFLEgldFTIVNVALPSIAADLGAS------SAQLGWIVSAYLLGRAIGLLLFGRLGD 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 103 RYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGSFNGLLGPI-KAYAMEIFRDEYQGLALSAVSTAWGIGLIIG 181
Cdd:COG0477  75 RYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGaLALIAELFPARERGRALGLWGAAIGLGLALG 154


                ....*....
gi 30684565 182 PAIGGFLAQ 190
Cdd:COG0477 155 PLLGGLLVA 163

MFS_NepI_like

cd17324

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...

79-469

2.71e-14

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 74.12 E-value: 2.71e-14

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  79 AGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGSFNGLLGPIK-AYAMEI 157
Cdd:cd17324  36 AGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAaAYAADL 115

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 158 FRDEYQGLALSAVSTAWGIGLIIGPAIGGFLAQpakqypsLFSQDSIFgkfpfflpcLAISVFAFLVTIVSSRIpetlhn 237
Cdd:cd17324 116 VPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQ-------LLGWRAAF---------LAIAVLALLAALLLWRL------ 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 238 hkfnddesydalkdLSDDPESNKVAERNGKS--SLLNNWPLISS-IIVYCVFSLHDMAYTEIfslwanSPRKYGGLGYST 314
Cdd:cd17324 174 --------------LPSLPPKKPGSLGLLSSllLLLRNPRLRLAyLITFLLFGGFFALYTYL------APFLTDVPGFSS 233

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 315 ADVGSVLAFSGFGLLIFQLSLYSYAERllGPIIVTRISGSLAMVVLSCYPLIAKLSGLALTVTVtsasvaksVLGTSAIT 394
Cdd:cd17324 234 SAIIGLLLLFGVAGVVGSPLAGRLADR--GGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLV--------LWGLGFFA 303

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 30684565 395 GLFILQNKAVR--QDQRGAANGIAMTAMSLFKAIGPAAAGIIFSWSekrqgaaflpGTQMVFFILNVVLALGVVLTF 469
Cdd:cd17324 304 AHSALQTRVLRlaPEARGLASSLYLAAYNLGGALGAALGGLVLDHG----------GWAGVGWVGAALLLLALLLAL 370

FucP

COG0738

Fucose permease [Carbohydrate transport and metabolism];

26-470

6.59e-13

Fucose permease [Carbohydrate transport and metabolism];

Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 69.88 E-value: 6.59e-13

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  26 MKRLRRGFPFWELFTVWIIvlcTALPISSLFPFLYFMIDDFNIAKkeedigFYAGFVGCSFMLGRAFTSVAWGLVADRYG 105
Cdd:COG0738   1 MSKKNYRRALIAIYLLFFL---WGFATALWGPLIPALKDAFGLSD------AQAGLLLFAFFLGYLLASLPAGRLIDRFG 71

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 106 RKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGSFNGLLGP-IKAYAMEIFRdEYQGLALSAVSTAWGIGLIIGPAI 184
Cdd:COG0738  72 YKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVaANPYVAALGP-ETAASRLNLLHAFFSLGALLGPLL 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 185 GGFLaqpakqypsLFSQDSIFGKFPFFLpcLAISVFAFLVTIVSSRIPETlhnhkfnddesydalkdlsDDPESNKVAER 264
Cdd:COG0738 151 GGLL---------ILLGLSLSWHLPYLI--LAVLLLLLALLFLRSKLPEI-------------------EEEEEEAAGSA 200

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 265 NGKSSLLNNWPLISSIIVYCVFSLHDMAYTEIFSLWANSprkygGLGYSTADVGSVLAFSGFGLLIFqlslysyaeRLLG 344
Cdd:COG0738 201 ASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKD-----VLGLSEATAALGLSLFWGGMTIG---------RFLG 266

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 345 PIIVTRISGSLAMVVLSCypliakLSGLALTVTVTSASVAKSVLGTsAITGLFI------LQNKAVRQ--DQRGAANGIA 416
Cdd:COG0738 267 GFLLKRFGPVRLLRLSAL------LAAVGLLLALLAPGPWLALIGL-ALVGLGLslmfptIFSLALDGlgKRTAAAVSAV 339

                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....
gi 30684565 417 MTAMSLFKAIGPAAAGIIFSWSekrqgaaflpGTQMVFFILNVVLALGVVLTFK 470
Cdd:COG0738 340 LIMGIVGGAIGPPLIGFLADAF----------GLRAAFLVPLVCYLLILLLALA 383

MFS_TetA

cd17388

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...

43-472

1.86e-12

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 68.82 E-value: 1.86e-12

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  43 IIVLCTALPISSLFPFLYFMIDDFniAKKEEDIGFYAGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNT 122
Cdd:cd17388   6 VTVLLDAMGIGLIMPVLPTLLREF--VGDSADAATHYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDYL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 123 LFGLSLNFWMAIITRFCLGSFNGLLGPIKAYAMEIFRDEYQGLALSAVSTAWGIGLIIGPAIGGFLAQPAKQYPslfsqd 202
Cdd:cd17388  84 LMAFAPTLWWLYLGRIIAGITGATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGEISPRAP------ 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 203 sifgkfpfFLPCLAISVFAFLVtiVSSRIPETLHNHKFNDdesydalkdlSDDPESNKVaernGKSSLLNNWPLISSIIV 282
Cdd:cd17388 158 --------FLVAAGLNGLNFLL--GLFVLPESLPPERRRA----------FRWRRANPF----GSLRWLTGFPGLLGLLA 213

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 283 ycVFSLHDMAYTEIFSLWAnsprKYGG--LGYSTADVGSVLAFSGFGLLIFQLSLYSYAERLLG---PIIVTRISGSLAM 357
Cdd:cd17388 214 --VFFLIQLIGQVPATTWV----LFTEdrFDWSPTMVGLSLAVFGLLHALFQAFVTGPIAKRLGekrAILLGLAADALGF 287

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 358 VVLScyplIAKLSGLALTVTVTSAsvaksvLGTSAITGLFILQNKAVRQDQRGAANGIAMTAMSLFKAIGPAAAGIIFSW 437
Cdd:cd17388 288 LLLA----FATQGWMVFPILILLA------LGGIAGPALQGLLSRQVPENEQGELQGVLTSLTSLTSIIGPLLFTGIFAA 357

                       410       420       430
                ....*....|....*....|....*....|....*
gi 30684565 438 SekrqgAAFLPGTqmVFFILNVVLALGVVLTFKPF 472
Cdd:cd17388 358 S-----PATWPGL--AWIIGAALYLICLVLAYRFF 385

MFS_MdtH_MDR_like

cd17329

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...

38-467

2.03e-12

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 68.41 E-value: 2.03e-12

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  38 LFTVWIIVLCTALPISSLFPFLY-FMIDDFNIAkkeediGFYAGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTAS 116
Cdd:cd17329   1 LWVLLIGSFLNRLGFFMVWPFMAiYLHQQLGLS------ASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLL 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 117 VVVFNTLFGLSLNFWMAIITRFCLGSFNGLLGP-IKAYAMEIFRDEYQGLALSAVSTAWGIGLIIGPAIGGFLAQpakqy 195
Cdd:cd17329  75 RALGFALLGFAHSPWLFAIALVLTGFGGGLFEPaSEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLL----- 149

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 196 pslfsqdsifgkFPFFLPCLAISVFAFLVTIVSSRIPetlhnhkfnddesydalkdlsddPESNKVAERNGKSSLLNNWP 275
Cdd:cd17329 150 ------------YSFRLLFLAAAVLFLLAALVLLFLL-----------------------PETRPKRRAAEKTEILRGYK 194

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 276 LISSIIVYCVFSLHDMAYTEIFSLWANSPRKYGG--LGYSTADVGSVLAFSGFGLLIFQLSLYSYAERlLGPIIVTRISG 353
Cdd:cd17329 195 IVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVeiLGLGESLLGLLLALNALLIVLLQFPVARLVER-FRLRKILMIGI 273

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 354 SLAMVVLSCYPLIAKLSGLALTVTVtsASVAKSVLGTSAITglfiLQNKAVRQDQRGAANGIAMTAMSLFKAIGPAAAGI 433
Cdd:cd17329 274 LLFAIGFAVLAFANTLAVLILAMIV--LTLGEMLVFPAVQT----LVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGL 347

                       410       420       430
                ....*....|....*....|....*....|....
gi 30684565 434 IFSwsekrqgaafLPGTQMVFFILNVVLALGVVL 467
Cdd:cd17329 348 LLD----------LLGPGLPWLILAALGLIAAAL 371

MFS_MdtG_MDR_like

cd17391

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...

41-226

1.67e-11

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 65.75 E-value: 1.67e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  41 VWIIVLCTALPISSLFPFLYFMIDDFNIAKKEEdIGFYAGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILigTASVVVF 120
Cdd:cd17391   1 CWLGNFFTGIGFSLIAPFLPLYIEQLGVTSGGL-VELWSGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLL--RASLGMA 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 121 NTLFGLSL--NFWMAIITRFCLGSFNGLLGPIKAYAMEIFRDEYQGLALSAVSTAWGIGLIIGPAIGGFLAQpakqypsl 198
Cdd:cd17391  78 IVIGLMAFvtNVWQLLILRLLQGVFSGYVPNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLAD-------- 149

                       170       180
                ....*....|....*....|....*...
gi 30684565 199 fsqdsIFGKFPFFLPCLAISVFAFLVTI 226
Cdd:cd17391 150 -----LFGIRNVFFITGGLLFLAFLLTL 172

MFS_MFSD9

cd17390

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...

77-439

1.88e-11

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 65.33 E-value: 1.88e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  77 FYAGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGSFNGLLGPIKAYAME 156
Cdd:cd17390  31 TVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPLGIFKHTQSLCKAYLSD 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 157 IFRDEYQGLALSAVSTAWGIGLIIGPAIGGFLAQPAKQypslfsqdsifgkfpFFLPCLAIS-VFAFLVTIVssripetl 235
Cdd:cd17390 111 LVSEQERSRVLGRFNAASSLGFILGPVVGGHLAETDGG---------------FYYVALLCSaIFILNAGLV-------- 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 236 hnhkfnddesYDALKDLSDdpesnkvaerngkssLLnnwplissiIVYCVFSLHDMAYTEIFSLWA----NSPRKYGglG 311
Cdd:cd17390 168 ----------WFLLSKLWD---------------LL---------LVRFLMGFSVLLFRSNFSLYLeerfDLSPKTI--G 211

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 312 YSTADVGSVLAFSGFGL-LIFQLSLYSYAERLLGPIIVTRISGSLAMVVLSCYPLIaklsgLALTVTVTSASVAKsVLGT 390
Cdd:cd17390 212 YLISYSGVLGALSGFLVgRILKLYKNNEYLLLLHSFILLALSLLGLALAPSIWLLV-----LCLTPLSISSAVLR-TCST 285

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*....
gi 30684565 391 SaitglfiLQNKAVRQDQRGAANGIAMTAMSLFKAIGPAAAGIIFSWSE 439
Cdd:cd17390 286 S-------LLLSRGKSKERGTLLGVGQSVTSLARILAPLLSGLLQEFSV 327

2_A_01_02

TIGR00880

Multidrug resistance protein;

85-234

3.17e-11

Multidrug resistance protein;

Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 61.13 E-value: 3.17e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565    85 SFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGSFNGLLGPI-KAYAMEIFRDEYQ 163
Cdd:TIGR00880   6 GYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAgAALIADIYPPEER 85

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 30684565   164 GLALSAVSTAWGIGLIIGPAIGGFLAQpAKQYPSLFsqdsifgkfpFFLPCLAISVFAFLVTIvssrIPET 234
Cdd:TIGR00880  86 GVALGLMSAGIALGPLLGPPLGGVLAQ-FLGWRAPF----------LFLAILALAAFILLAFL----LPET 141

MFS_YfmO_like

cd17474

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...

85-470

4.60e-11

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 64.13 E-value: 4.60e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  85 SFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGSFNGLLGPIkAYAM--EIFRDEY 162
Cdd:cd17474  42 AFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLGPL-ALTLigDLFEGGE 120

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 163 QGLALSAVSTAWGIGLIIGPAIGGFLAQPAKQYpslfsqdsifgkfPFFLPCLAIsVFAFLVTIVssrIPEtlhnhkfnd 242
Cdd:cd17474 121 RAKAMGLYEAALGLGIAVGPLLGGLLAAISWRY-------------PFFLLAALI-PVAFLAILF---LLP--------- 174

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 243 desydalKDLSDDPESNKVAERNGKSSLLNNWPLISSIIVYCVFSLHdmaYTEIFSLWANSPRKYGGlgySTADVGSVLA 322
Cdd:cd17474 175 -------EPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLY---FAFLTYLPFLLELLYGI---SPIIIGLLFA 241

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 323 FSGFGLLIFQLslysyaerLLGPIIVTRISGSLAMVV-LSCYPLIAKLSGLALTVTV-TSASVAKSVLGTSAITGLFILQ 400
Cdd:cd17474 242 GWSVLLALGSL--------FVGRLLKKRFGARRILVIgLLLYALSLLLLGFVPSLALlLIAIVLFGLGLGLNLPLLTTLV 313

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 401 NKAVRQDQRGAANGIAMTAMSLFKAIGPAAAGIIFSWSekrqgaaflpGTQMVFFILNVVLALGVVLTFK 470
Cdd:cd17474 314 TELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIF----------GLSAPFLVGAAIALAAAVLLAL 373

MFS_MMR_MDR_like

cd17321

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...

85-469

8.07e-11

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 63.35 E-value: 8.07e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  85 SFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGSFNGLLGPIK-AYAMEIFRDEYQ 163
Cdd:cd17321  39 AYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAIMPASlALIAATFPGERR 118

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 164 GLALSAVSTAWGIGLIIGPAIGGFLAQpakqypsLFSQDSIfgkfpfFLPCLAISVFAFLVTIVSSripetlhnhkfndd 243
Cdd:cd17321 119 GRALGLWGAVVGIGAALGPLLGGLLLE-------LFGWRWI------FLINVPIGLVALLLARTFS-------------- 171

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 244 esydalkdlsddpesnkvaerngkssllnnWPLISSIIVYCVFslhdMAYTEIFSLWANsprkyGGLGYSTADVGsvLAF 323
Cdd:cd17321 172 ------------------------------GAVLAAFLLGAAL----GGLLFLLPLYLQ-----GVLGYSPLQAG--LAL 210

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 324 SGFGLLIFQLSlysyaerLLGPIIVTRIsGSLAMVVLSCypLIAKLSGLALTVTVTSASVAKSVLGT--------SAITG 395
Cdd:cd17321 211 LPLALAMLVAA-------PLAGRLADRF-GPRLVLVAGL--LLTAVGLLLLALLGADSSVWLLLPGLvllglglgLFATP 280

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 396 LFILQNKAVRQDQRGAANGIAMTAMSLFKAIGPAAAGIIFSWSEKR-------------QGAAFLPGTQMVFFILNVVLA 462
Cdd:cd17321 281 LTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLTAGLSAnlgdsgvaallsaAAAAFAAGFHLAFLVAAALAL 360


                ....*..
gi 30684565 463 LGVVLTF 469
Cdd:cd17321 361 LAALLAL 367

MFS_MefA_like

cd06173

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...

76-470

1.32e-10

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 63.02 E-value: 1.32e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  76 GFYAGFVGCSFMLGRAFTSVAWGLVADRYGRKPV-----ILIGTASVVVFNTLFGLSLNFWMAIITRFCLGSFNGLLGPI 150
Cdd:cd06173  33 ALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLliladLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPA 112

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 151 K-AYAMEIFRDEYQGLALSAVSTAWGIGLIIGPAIGGFLaqpakqypslfsqdsiFGKFPFFLPCLAISVFAFLVTIVSS 229
Cdd:cd06173 113 RqALLPELVPKEQLVRANALNSLATQLARIIGPALGGLL----------------VALLGPGGAFAINALSFLLSALLLL 176

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 230 RIPetlhnhkfnddesYDALKDLSDDPESNKVAERNGKSSLLNNWPLISSIIVYCVFSLHDMAYTEIFSLWANSPrkygg 309
Cdd:cd06173 177 FIR-------------RPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEV----- 238

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 310 LGYSTADVGSVLAFSGFGLLIfqlslysyaerllGPIIVTRISGSLAMVVLScyPLIAKLSGLALTVTVTSASVAKSVLG 389
Cdd:cd06173 239 LGGGAAGYGLLLAAFGVGALL-------------GALLLGRLSKRRRRGRLL--LIGALLLGLALLVLGLSPSLWLLLAA 303

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 390 ---TSAITGLFILQNKAVRQ-----DQRGAANGIAMTAMSLFKAIGPAAAGIIFSWSekrqgaaflpGTQMVFFILNVVL 461
Cdd:cd06173 304 lflLGLAGGLFNVPLNTLLQlrvpdELRGRVFSVYNALNSGAMPLGALLAGLLADAL----------GLSAVFLLAGALL 373


                ....*....
gi 30684565 462 ALGVVLTFK 470
Cdd:cd06173 374 LLAALLLLL 382

AraJ

COG2814

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];

27-177

1.25e-09

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];

Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 59.60 E-value: 1.25e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  27 KRLRRGFPFWELFTVWIIVLCTALPISSLFPFL-YFMIDDFNIAkkEEDIGFYAGFVGCSFMLGraftSVAWGLVADRYG 105
Cdd:COG2814 198 GSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLpLYLQEVLGLS--ASAAGLLLALFGLGGVLG----ALLAGRLADRFG 271

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 30684565 106 RKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGSFNGLLGP-IKAYAMEIFRDEYQGLALSAVSTAWGIG 177
Cdd:COG2814 272 RRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPlLQALVAELAPPEARGRASGLYNSAFFLG 344

PRK09874

multidrug efflux MFS transporter MdtG;

38-230

1.36e-09

multidrug efflux MFS transporter MdtG;

Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 59.93 E-value: 1.36e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565   38 LFTVWIIVLCTALPISSLFPFLYFMIDDFNIAKKEEdIGFYAGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASV 117
Cdd:PRK09874  16 LTVAWLGCFLTGAAFSLVMPFLPLYVEQLGVTGHSA-LNMWSGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSALGM 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  118 VVFNTLFGLSLNFWMAIITRFCLGSFNGLLGPIKAY-AMEIFRDEyQGLALSAVSTAWGIGLIIGPAIGGFLAQPakqyp 196
Cdd:PRK09874  95 GIVMVLMGLAQNIWQFLILRALLGLLGGFVPNANALiATQVPRNK-SGWALGTLSTGGVSGALLGPLAGGLLADS----- 168

                        170       180       190
                 ....*....|....*....|....*....|....
gi 30684565  197 slfsqdsiFGKFPFFLPCLAISVFAFLVTIVSSR 230
Cdd:PRK09874 169 --------YGLRPVFFITASVLFLCFLVTLFCIR 194

MFS_SLC22

cd17317

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...

77-185

1.65e-09

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 59.13 E-value: 1.65e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  77 FYAGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLG-SFNGLLGPIKAYAM 155
Cdd:cd17317  25 WLVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGvTSAGIFTVGFVLGM 104

                        90       100       110
                ....*....|....*....|....*....|
gi 30684565 156 EIFRDEYQGLALSAVSTAWGIGLIIGPAIG 185
Cdd:cd17317 105 EIVGPKYRSFVGILFGLFWALGYMLLALLA 134

MFS_Tpo1_MDR_like

cd17323

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...

38-190

3.34e-09

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 58.36 E-value: 3.34e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  38 LFTVWIIVLCTALPISSLFPFLYFMIDDFNIAKKEEDIGFyagfvgCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASV 117
Cdd:cd17323   1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGV------SLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIF 74

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 30684565 118 VVFNTLFGLSLNFWMAIITRFCLGSFNGLLGPIKAYAM-EIFRDEYQGLALSAVSTAWGIGLIIGPAIGGFLAQ 190
Cdd:cd17323  75 VIFQIGCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIaDLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQ 148

2A0115

TIGR00895

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...

79-188

4.90e-09

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]

Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 58.14 E-value: 4.90e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565    79 AGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLG-SFNGLLGPIKAYAMEI 157
Cdd:TIGR00895  54 LGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGlGLGGLMPNLNALVSEY 133

                          90       100       110
                  ....*....|....*....|....*....|.
gi 30684565   158 FRDEYQGLALSAVSTAWGIGLIIGPAIGGFL 188
Cdd:TIGR00895 134 APKRFRGTAVGLMFCGYPIGAAVGGFLAGWL 164

MFS_SV2_like

cd17316

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...

79-188

5.82e-09

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 57.61 E-value: 5.82e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  79 AGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLG-SFNGLLGPIKAYAMEI 157
Cdd:cd17316  38 TGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGiGIGGEYPGASTYVAEF 117

                        90       100       110
                ....*....|....*....|....*....|.
gi 30684565 158 FRDEYQGLALSAVSTAWGIGLIIGPAIGGFL 188
Cdd:cd17316 118 APSKRRGFALGLLQSGWALGALLAALVASLL 148

PRK12307

MFS transporter;

38-330

8.93e-09

MFS transporter;

Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 57.25 E-value: 8.93e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565   38 LFTVWIIVLCTALPISSLFPFLYFMIDDFNIAKKEedigfyAGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASV 117
Cdd:PRK12307  20 LFSAWLGYVFDGFDFMLIFYIMYLIKADLGLTDME------GAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSIVAY 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  118 VVFNTLFGLSLNFWMAIITRFCLG-SFNGLLGPIKAYAMEIFRDEYQGLALSAVSTAWGIGLIIGpaiggflAQPAKQYP 196
Cdd:PRK12307  94 SVGTGLSGLASGVIMLTLSRFIVGmGMAGEYACASTYAVESWPKHLKSKASAFLVSGFGIGNIIA-------AYFMPSFA 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  197 SLFSQDSIFgkFPFFLPCLaisvfafLVTIVSSRIPETlhnhkfnDDESYDALKDLSDDPESNKVAERNGKSSLLNNWPL 276
Cdd:PRK12307 167 EAYGWRAAF--FVGLLPVL-------LVIYIRARAPES-------KEWEEAKLSGKGKHSQSAWSVFSLSMKGLFNRAQF 230

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 30684565  277 ISSIIVYCV-FSLHDmAYTEIFSLWansPRKYGGLGYSTADVGSVLAFSGFGLLI 330
Cdd:PRK12307 231 PLTLCVFIVlFSIFG-ANWPIFGLL---PTYLAGEGFDTGVVSNLMTAAAFGTVL 281

NarK

COG2223

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];

38-469

1.01e-08

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];

Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 57.20 E-value: 1.01e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  38 LFTVWIIVLCTALPISSLFPFLYFMIDDFNIAkkEEDIGFYAGFvgcsFMLGRAFTSVAWGLVADRYGRKPVILIGTASV 117
Cdd:COG2223   7 LLLATLAFFLAFGVWYLWSVLAPPLAEEFGLS--AAQLGLLFAI----PVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 118 VVFNTLFGLSLNFWMAIITRFCLGSFNGLL-GPIKAYAMEIFRDEYQGLALsAVSTAWGiglIIGPAIGGFLAQPakqyp 196
Cdd:COG2223  81 GIGLLLLALAVSYWLLLLLGLLLGIGGGGSfAVGIALVSKWFPPDRRGLAL-GLAAGGG---NLGAAVAAFLAPL----- 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 197 slfsqdsIFGKFPFFLPCLAISVFAFLVTIVSSRIpetlhnhkfnddesydaLKDLSDDPESNKVAERNGKSSLLNNWPL 276
Cdd:COG2223 152 -------LIAAFGWRNAFLILGILLLVVAVLAWLF-----------------LRDPPAGAAAAAKASLRDQLEALRDPRF 207

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 277 ISSIIVYCVFSLHDMAYTEIFSLWANSprkygGLGYSTADVGSVLA-FSGFGLLIfqlslysyaeRLLGPIIVTRISGSL 355
Cdd:COG2223 208 WLLSLLYFGTFGSFIGFSSWLPPYLVD-----QFGLSAATAGLLAAlFALLGALG----------RPLGGWLSDRIGGRR 272

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 356 AMVVLSCYPLIAKLSGLALTVTVTSASVAKSVLGTSAITG---LFILQNKAVRQDQRGAANGIAMTAMSLFKAIGPAAAG 432
Cdd:COG2223 273 VLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGngaVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFG 352

                       410       420       430
                ....*....|....*....|....*....|....*..
gi 30684565 433 IIFSWSEkrqgaaflpGTQMVFFILNVVLALGVVLTF 469
Cdd:COG2223 353 ALLDATG---------SYTAAFLVFAVLALVALVLTL 380

MFS_MdfA_MDR_like

cd17320

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...

86-240

1.28e-08

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 56.82 E-value: 1.28e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  86 FMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGsFNGLLGPIKAYAM--EIFRDEYQ 163
Cdd:cd17320  43 YLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQG-LGAAAGSVVARAIvrDLYSGAEL 121

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 30684565 164 GLALSAVSTAWGIGLIIGPAIGGFLAQpakqypsLFSQDSIFgkfpfflpcLAISVFAFLVTIVSS-RIPETLHNHKF 240
Cdd:cd17320 122 AKIFSLLMMILAIAPALAPLLGGLLLL-------FFGWRAIF---------VFLALLGLLLLLLVLlFLPETLPEEKR 183

MFS_SLC22A18

cd17331

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...

98-436

1.64e-08

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 56.46 E-value: 1.64e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  98 GLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGSFNGLLGPIKAYAMEIFRDEyQGLALSAVSTAWGIG 177
Cdd:cd17331  56 GRFGDLFGPRAALVLSFLSSALSYLLLAFASSVPMLFLSRLPSVFMHAMQAAQMVVTDLTDPGE-RAAALGRLGLSYGIG 134

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 178 LIIGPAIGGFLAqpakqypslfsqdsifGKFPFFLPCLAISVFAFLVTIVSSRIPEtlhnhkfndDESYDALKDLSDDPE 257
Cdd:cd17331 135 MVVGSFLGGLLT----------------KKFGEQAAALVAAVGSLLSIVLVILLIP---------SNTKSKREKEAKESA 189

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 258 SNKVAERNGKSSLLNNWPLISSIIVYCVFSLHDMA-YTEIFSLWANSPrkyggLGYSTADVGSVLAFSGFGLLIFQLSLY 336
Cdd:cd17331 190 SPPSVFNLKEILRLLRLPGVAFLLLVKLLSGLPIGmFQSMFSLVAMDF-----FGLTPEENGYLMSYAGVLGMVVQGLLV 264

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 337 SYAERLLGPIIVTRISgSLAMVVlsCYPLIAKLS----GLALTVTVTSASVAKSVLGTSAITglfilqnKAVRQDQRGAA 412
Cdd:cd17331 265 GPLTKRFGERSLLKLS-VALLAI--GYLLLAFVTtvwqLLVLLLPLVIGGSVLYTVITSLLT-------KAVPPEDTGTA 334

                       330       340
                ....*....|....*....|....
gi 30684565 413 NGIAMTAMSLFKAIGPAAAGIIFS 436
Cdd:cd17331 335 LGLSHALFSLVRTVSPTIGGALLQ 358

UhpC

COG2271

Sugar phosphate permease [Carbohydrate transport and metabolism];

35-230

2.94e-08

Sugar phosphate permease [Carbohydrate transport and metabolism];

Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 55.65 E-value: 2.94e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  35 FWELFTVWIIVLCTALPISSLFPFLY----FMIDDFNIAKKEedigfyAGFVGCSFMLGRAFTSVAWGLVADRYGR--KP 108
Cdd:COG2271 176 LLALLRFWLLALAYFLVYFALYGFLTwlptYLVEVRGLSLAQ------AGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKL 249

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 109 VILIGTASVVVFNTLFGLSLNFWMAIITRFCLGSF-NGLLGPIKAYAMEIFRDEYQGLALSAVSTAWGIGLIIGPAIGGF 187
Cdd:COG2271 250 VLAIGLLLAALALLLLALLPSPALAIALLFLAGFGlGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGY 329

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 30684565 188 LAQpakqypslfsqdsIFGKFPFFLPCLAISVFAFLVTIVSSR 230
Cdd:COG2271 330 LLD-------------ATGYQAAFLLLAALALLAALLALLLLR 359

MFS_MFSD10

cd17389

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...

78-236

3.97e-08

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 55.36 E-value: 3.97e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  78 YAGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGSFNGLLGPIKAYAMEI 157
Cdd:cd17389  65 FGGLIGSLFSLLQFLSSPITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKGNVSLSTAIVADV 144

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 158 FRDEYQGLALSAVSTAWGIGLIIGPAIGGFLAqpakqypslfSQDSIFGKFPFFLPCLAISVFAFLVTI-VSSRIPETLH 236
Cdd:cd17389 145 TSPKKRSKGMALIGVAFSLGFIIGPMIGAYFA----------SFTRSLGEVFFSMPALFALVLALADLLfIFFFLPETLP 214

MFS_YfcJ_like

cd17489

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...

79-468

4.24e-08

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 54.91 E-value: 4.24e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  79 AGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGSFNGLLGP-IKAYAMEI 157
Cdd:cd17489  33 AGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTaAATLVADI 112

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 158 FRDEYQGLALSAVSTAWGIGLIIGPAIGGFLAQpAKQYPSLFsqdsifgkfpfflpcLAISVFAFLVTIVSSRIPETLHN 237
Cdd:cd17489 113 IPPSRRGEGIGYYGLATTLAMALGPALGLFLYQ-HLGFAVLF---------------IVAAVLALLALLLVFLVKDPPPV 176

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 238 HKfnddesydalkdlsddpeSNKVAERNGKSSLLNNWPLISSIIVYCVFslhdMAYTEIFS---LWANSprkyggLGYST 314
Cdd:cd17489 177 AA------------------EEAEAGTRAFRRLVEKKVLPPALILFLAS----IAYGAISTflpLYAAE------RGISN 228

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 315 AdvGSVLAFSGFGLLIFQLSLYSYAERlLGPIIVTRISGSLAMVVLSCypliaklsgLALTVTVTSASVAKSVLGTSAIT 394
Cdd:cd17489 229 A--GLFFTVYAIALLLSRPFSGKLSDR-KGPKTVIIPGLLLLALGLLL---------LSFAGSPWMLLLAAVLYGLGFGL 296

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 30684565 395 GLFILQNKAVR---QDQRGAANGIAMTAMSLFKAIGPAAAGIIFSWSekrqgaaflpGTQMVFFILNVVLALGVVLT 468
Cdd:cd17489 297 LFPALQALAVDlvpPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELF----------GYRAMFLLAAVVVLLALVLY 363

MFS_LmrB_MDR_like

cd17503

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...

85-188

8.33e-08

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 54.12 E-value: 8.33e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  85 SFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGSFNGLLGPI-KAYAMEIFRDEYQ 163
Cdd:cd17503  39 SYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIPLaQTILLRIYPPEKR 118

                        90       100
                ....*....|....*....|....*
gi 30684565 164 GLALSAVSTAWGIGLIIGPAIGGFL 188
Cdd:cd17503 119 GAAMGLVGLVILLAPAIGPTLGGWL 143

CynX

COG2807

Cyanate permease [Inorganic ion transport and metabolism];

27-469

1.81e-07

Cyanate permease [Inorganic ion transport and metabolism];

Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 53.34 E-value: 1.81e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  27 KRLRRGFPFWELFTVWIIVLCTALPISSLFPFLYFMIDDFNIAkkeediGFYAGFVGCSFMLGRAFTSVAWGLVADRYGR 106
Cdd:COG2807   9 RRSRRAGRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLS------ATQAGLLTTLPLLAFGLFAPLAPRLARRFGL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 107 KPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGSFNGLLGP-----IKAYAmeifrDEYQGLALSAVSTAWGIGLIIG 181
Cdd:COG2807  83 ERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVllpglIKRWF-----PDRVGLMTGLYTAAMGLGAALA 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 182 PAIGGFLAQPAKQYPSLfsqdsifgkfpfflpcLAISVFAFLVTIVSsrIPETLHNHkfnddesydalkdlsddPESNKV 261
Cdd:COG2807 158 AGLTVPLAAALGWRGAL----------------AVWALLALLALLLW--LPLLRRRP-----------------AAAAAA 202

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 262 AERNGKSSLLNNWPLissIIVYCVFSLHDMAYTEIFSlWAnsPRKYGGLGYSTADVGSVLAFSGFGLLIFqlslysyaeR 341
Cdd:COG2807 203 PAAASLRSLWRSPLA---WLLTLFFGLQSLLYYAVVA-WL--PPILRDAGLSAATAGLLLSLFQLAGIPG---------S 267

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 342 LLGPIIVTRISGSLAMVVLSCYPLIAKLSGLAL---TVTVTSASVAKSVLGTSAITGLFILQNKAVRQDQRGAANGIAMT 418
Cdd:COG2807 268 LLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLapgSLPWLWAVLLGLGQGGLFPLALTLIGLRARTPAEAAALSGMAQS 347

                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|.
gi 30684565 419 AMSLFKAIGPAAAGIIFSWSekrqgaaflPGTQMVFFILNVVLALGVVLTF 469
Cdd:COG2807 348 VGYLLAALGPLLVGALHDAT---------GSWTAALLLLAALAVLMLVAGL 389

PRK08633

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated

67-469

2.15e-07

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated

Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 53.77 E-value: 2.15e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565    67 NIAKK---EEDIGFYAGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSL---NFWMAIITRFCL 140
Cdd:PRK08633   34 NTLIKaydGSEQVILTAIVNALFLLPFLLLSSPAGFLADKFSKNRVIRIVKLFEVGLTLLIVLAYylgWFWLAFAVTFLL 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565   141 GSFNGLLGPIKA-YAMEIFRDEYQGLALSAVSTAWGIGLIIGPAIGGFLAQpaKQYPslfSQDSIFGKFPFFLPCLAIsV 219
Cdd:PRK08633  114 GAQSAIYSPAKYgIIPELVGKENLSRANGLLEAFTIVAILAGTALFSFLFE--SVNG---NTPSEILGRIAPAGLVLL-A 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565   220 FAFLVTIVSSRIPETLHnhkfnddesydALKDLSDDPESNKVAE--RNGKsSLLNNWPLISSIIVYCVFSLHDMAYTEIF 297
Cdd:PRK08633  188 VAVLGLIFAYRLPKVPA-----------AAPEVFDKKKYLFPKLlwRNLK-LLRSDRVLWLAIIGLSYFWFISQLAQANF 255

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565   298 SLWAnspRKYGGLGySTADVGSVLAFSGFGLLIfqlslysyaerllGPIIVTRISGS---LAMVVLSCYPLIAKLSGLAL 374
Cdd:PRK08633  256 PAYA---KEVLGLD-NTFQVQYLLAASAIGIGI-------------GSLLAGRLSGRhieLGLVPLGALGLALSLFLLPT 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565   375 TVTVTSASVAKSVLGTSAitGLFI------LQNKAvRQDQRG----AANGIAMTAMSLFKAIGPAAAGIIFSwsekrqga 444
Cdd:PRK08633  319 APSLASVLVLFFLFGFSA--GLFIvplnalIQFRA-PEKELGkvlaANNFLQNVGMLLFLALTTLFSGLGLS-------- 387

                         410       420
                  ....*....|....*....|....*
gi 30684565   445 aflpgTQMVFFILNVVLALGVVLTF 469
Cdd:PRK08633  388 -----PAGLFYLIALVTLIGTLYTL 407

MFS_spinster_like

cd17328

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...

59-190

6.45e-07

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 51.47 E-value: 6.45e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  59 LYFMiDDFNIA------KKEEDIG-FYAGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFW 131
Cdd:cd17328  10 LNYM-DRFTIAgvlpdiQSDFLIDdSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFW 88

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 30684565 132 MAIITRFCLG----SFNGLLGPIKAyamEIFRDEYQGLALSAVSTAWGIGLIIGPAIGGFLAQ 190
Cdd:cd17328  89 QLLLFRALVGigeaSYSPIAPTIIA---DLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQ 148

MFS_MJ1317_like

cd17370

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...

86-190

7.07e-07

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 51.39 E-value: 7.07e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  86 FMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGSFNGL-LGPIKAYAMEIFRDEYQG 164
Cdd:cd17370 243 FNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAqESIERAAVADLVPAELRG 322

                        90       100
                ....*....|....*....|....*.
gi 30684565 165 LALSAVSTAWGIGLIIGPAIGGFLAQ 190
Cdd:cd17370 323 TAYGLFNTVVGIGWLLASLIAGYLWD 348

MFS_ExuT_GudP_like

cd17319

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...

61-189

1.07e-06

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 50.65 E-value: 1.07e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  61 FMIDDFNIAKKEedigfyAGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCL 140
Cdd:cd17319  28 TIMKDLGLSPTQ------YGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLL 101

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 30684565 141 GSFNGLLGPIKAYAM-EIFRDEYQGLALSAVSTAWGIGLIIGPAIGGFLA 189
Cdd:cd17319 102 GVAEAGFFPGAIKALaEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLL 151

MFS

cd06174

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...

22-226

1.30e-06

Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 50.50 E-value: 1.30e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  22 KVDQMKRLRRGFPFWELFTVWIIVLCTALPISSLFPFLYFMIDDFNIAkkeedigfYAGFVGCSFMLGRAFTSVAWGLVA 101
Cdd:cd06174 192 VLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVA--------VAGLLLSLFGLAGALGSLLLGLLS 263

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 102 DRY-GRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGSFNGLLGPI-KAYAMEIFRDEYQGLALSAVSTAWGIGLI 179
Cdd:cd06174 264 DRLiGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLsFALIAELFPPEIRGTAFGLLNTFGFLGGA 343

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 30684565 180 IGPAIGGFLaqpakqypslfsQDSIFGKFPFFLPCLAISVFAFLVTI 226
Cdd:cd06174 344 IGPLLAGFL------------LAATFGLTGAFLVLAVLLLLAAILLL 378

MFS_YfcJ_like

cd17489

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...

74-199

1.88e-06

Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 49.90 E-value: 1.88e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  74 DIGFYAGFVGCSFMLGRAFTsvawGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGSFNGLLGP-IKA 152
Cdd:cd17489 228 NAGLFFTVYAIALLLSRPFS----GKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPaLQA 303

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 30684565 153 YAMEIFRDEYQGLALSAVSTAWGIGLIIGPAIGGFLAQpAKQYPSLF 199
Cdd:cd17489 304 LAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAE-LFGYRAMF 349

MFS_MucK

cd17371

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...

75-179

2.39e-06

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 49.61 E-value: 2.39e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  75 IGFYAGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGSFNGLLGPIKAYA 154
Cdd:cd17371  32 DEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGEWAAGAAL 111

                        90       100
                ....*....|....*....|....*.
gi 30684565 155 M-EIFRDEYQGLALSAVSTAWGIGLI 179
Cdd:cd17371 112 MaEYVPARHRGKALGYVQSGWAVGWL 137

MelB

COG2211

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];

58-469

4.22e-06

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];

Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 49.13 E-value: 4.22e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  58 FLYFMIDDFNIAkkeedigfyAGFVGCSFMLGR---AFTSVAWGLVADRYG-----RKPVILIGTASVVVFNTL------ 123
Cdd:COG2211  33 LLYFYTDVLGLS---------AALVGLILLVARlwdAITDPLIGALSDRTRtrwgrRRPWILIGAIPLALSFVLlftapd 103

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 124 FGLSLNFWMAIITRFCLGSFNGLLG-PIKAYAMEIFRDEYQGLALSAVSTAWG-IGLIIGPAIGGFLAqpakqypSLFSQ 201
Cdd:COG2211 104 LSPTGKLIYALVTYLLLGLAYTLVNiPYSALGAELTPDYEERTRLSSWRFAFAgLGGLLASVLPPPLV-------AAFGG 176

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 202 DSIFGKFPFFLPCLAISVFAFLVTIVSSRIPETlhnhkfnddesydalkdlsddPESNKVAERNGKSSLLNNWPLISSII 281
Cdd:COG2211 177 DAALGYRLTALIFAVLGLLAFLLTFFGTKERPV---------------------PEEEKVSLKESLKALLKNRPFLLLLL 235

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 282 VYCVFSLHDMAYTEIFSLWANSprkygGLGYSTADVGSVLAFSGFGLLIFQLsLYSYAERLLGPIIVTRISGSLAMVVLS 361
Cdd:COG2211 236 AYLLFFLALALVAALLLYYFKY-----VLGLSAALVGLLLALYFLAALLGAP-LWPRLAKRFGKKKAFIIGLLLAALGLL 309

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 362 CYPLIAKLSGLALTVTVTSASVAKS---VLGTSAITGLFILQNKAVRQDQRGAANGIAMTAMSLFKAIGPAAAGIIFSW- 437
Cdd:COG2211 310 LLFFLGPGNLWLLLVLAALAGIGLGailVLPWAMLADVVDYDEWKTGRRREGLYFGIFTFAIKLGQALAGALAGLLLALf 389

                       410       420       430
                ....*....|....*....|....*....|....*
gi 30684565 438 ---SEKRQGAAFLPGTQMVFFILNVVLALGVVLTF 469
Cdd:COG2211 390 gyvAGAAQSPSALTGIRLLFFLLPAVLLLLAALLL 424

2A0121

TIGR00900

H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds]

87-436

4.92e-06

H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds]

Pssm-ID: 162098 [Multi-domain] Cd Length: 365 Bit Score: 48.47 E-value: 4.92e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565    87 MLGRAFTSVAWGLVADRYGRKPVILI-----GTASVVVFNTLFGLSLNFWMAIITRFCLGSFNGLLGP-IKAYAMEIFRD 160
Cdd:TIGR00900  44 MLPYVVLSPIAGALADRYDRKKVMIGadlirAVLVAVLPFVALLGGLNIWQVYVLAGILAIAQAFFTPaYQAMLPDLVPE 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565   161 EYQGLALSAVSTAWGIGLIIGPAIGGFLAQpakqypslfsqdSIFGKFPFFLPclAISVFAFLVTIVSSRIPE--TLHNH 238
Cdd:TIGR00900 124 EQLTQANSLSQAVRSLFYIVGPGIGGLMYA------------TLGIKWAIWVD--AVGFAISALLIVSVRIPElaASEIQ 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565   239 KFnddeSYDALKDLsddpesnkvaeRNGKSSLLNNWPLISSIIVYCVFSLHDMAYteIFSLWANSPRKYggLGYSTADVG 318
Cdd:TIGR00900 190 AL----SNAVLRDT-----------REGIKFVLKNPLLRTLLLLALLFNLVFAPA--IVALFPYVQSKY--LGRGSTHYG 250

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565   319 SVLAFSGFGLLIFQLsLYSYAERLLGPIIVTrisgSLAMVVLSCYPLIAKLSGLALTVTVTSASVAKSVLGTSAITGLFI 398
Cdd:TIGR00900 251 WVLAAFGLGALLGAL-LLGLLGRYFKRMALM----TGAIFVIGLAILVVGLTPPNFPLFLVLWFAIGVGYGPINVPQGTL 325

                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 30684565   399 LQnKAVRQDQRGAANGIAMTAMSLFKAIGPAAAGIIFS 436
Cdd:TIGR00900 326 LQ-RRVPAELLGRVFGAQFSLSHAAWPLGLILAGPLAD 362

PRK11102

Bcr/CflA family multidrug efflux MFS transporter;

85-236

5.42e-06

Bcr/CflA family multidrug efflux MFS transporter;

Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 48.37 E-value: 5.42e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565   85 SFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFclgsFNGLLGP-----IKAYAMEIFR 159
Cdd:PRK11102  34 AYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRF----LHGLAAAaasvvINALMRDMFP 109

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 30684565  160 DEYQGLALSAVSTAWGIGLIIGPAIGGFLAQpakqypsLFSQDSIFgkfpfflpcLAISVFAFLVTI-VSSRIPETLH 236
Cdd:PRK11102 110 KEEFSRMMSFVTLVMTIAPLLAPIIGGWLLV-------WFSWHAIF---------WVLALAAILAAAlVFFFIPETLP 171

2A0119

TIGR00898

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]

85-188

7.09e-06

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]

Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 48.47 E-value: 7.09e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565    85 SFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGSFNGLLGPIKAYAM-EIFRDEYQ 163
Cdd:TIGR00898 135 CFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNtEFLPKKQR 214

                          90       100
                  ....*....|....*....|....*
gi 30684565   164 GLALSAVSTAWGIGLIIGPAIGGFL 188
Cdd:TIGR00898 215 AIVGTLIQVFFSLGLVLLPLVAYFI 239

MelB

COG2211

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];

24-188

8.71e-06

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];

Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 47.97 E-value: 8.71e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  24 DQMKRLRRGFPFWELFtvwIIVLCTALPISSLFP-FLYFMIDDFNIAKKeedigfYAGFVGCSFMLGRAFTSVAWGLVAD 102
Cdd:COG2211 219 ESLKALLKNRPFLLLL---LAYLLFFLALALVAAlLLYYFKYVLGLSAA------LVGLLLALYFLAALLGAPLWPRLAK 289

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 103 RYGRKPVILIGTASVVVFNTLFGLSL--NFWMAIITRFCLGSFNGLLGPIkAYAMEIFRDEYQ---------GLALSAVS 171
Cdd:COG2211 290 RFGKKKAFIIGLLLAALGLLLLFFLGpgNLWLLLVLAALAGIGLGAILVL-PWAMLADVVDYDewktgrrreGLYFGIFT 368

                       170
                ....*....|....*..
gi 30684565 172 TAWGIGLIIGPAIGGFL 188
Cdd:COG2211 369 FAIKLGQALAGALAGLL 385

MFS_YcaD_like

cd17477

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...

76-462

9.04e-06

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 47.55 E-value: 9.04e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  76 GFYAGFVGCSFMLGRaftsvawglVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLG-SFNGLLGPIKAYA 154
Cdd:cd17477  39 AYYLGILLGSPLVPR---------LIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGiGLAGLFVVSESWL 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 155 MEIFRDEYQGLALSAVSTAWGIGLIIGPAIGGFLaqpakqypslfsqdSIFGKFPFFLPCLAISVFAFLVTIVSSRIPET 234
Cdd:cd17477 110 NALATNENRGRVLGLYSTVLGLGFALGPLLLALV--------------GTAGALPFLIAAVLLLLALVPLLLTRRAAPEI 175

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 235 lhnhkfnddesydalkdlsddpesnkvaERNGKSSLLNNWPLISSIIVYC-VFSLHDMAYTEIFSLWANSprkyggLGYS 313
Cdd:cd17477 176 ----------------------------EEAESISLRRLLRIAPLALLGAfVAGFLEGAFYSLLPLYGLR------LGLS 221

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 314 TADVGSVLAFSGFGLLIFQLSLYSYAERLlGPIIVTRISGSLAMVVLSCYPLIAKLSGLALTVTVtsasvaksVLGtSAI 393
Cdd:cd17477 222 VAQAALLLAAFVLGGLLLQWPLGWLADRF-DRRRVLLGCALLGALAALLLPLVPGLPLALLVLLF--------LWG-GAA 291

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 30684565 394 TGLF----ILQNKAVRQDQRGAANGIAMTAMSLFKAIGPAAAGIIFSWSekrqGAAFLPGTQMVFFILNVVLA 462
Cdd:cd17477 292 GPLYtlalALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAF----GPHGLFLFLAAVALLFLLFL 360

MFS_MT3072_like

cd17475

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...

42-189

1.03e-05

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 47.62 E-value: 1.03e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  42 WIIVLCTALPISSLFPFLYFMIDDFNIAKKEedIGFYAGFVGcsfmLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFN 121
Cdd:cd17475   2 TLAQAAASLVAQGIPALAPFLQEDLHLSLAQ--VGLLLSALN----LGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAA 75

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 30684565 122 TLFGLSLNFWMAIITRFCLGSFNGLLGPIKAYA-MEIFRDEYQGLALSAVSTAWGIGLIIGPAIGGFLA 189
Cdd:cd17475  76 LLMALVGSYPVLLVLLFLVGAGYGSVQPGGGRAiMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLA 144

MFS_Azr1_MDR_like

cd17502

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...

79-190

1.59e-05

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 46.79 E-value: 1.59e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  79 AGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGSFNGLLGPIkAYAM--E 156
Cdd:cd17502  32 VSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSL-AFIIiaD 110

                        90       100       110
                ....*....|....*....|....*....|....
gi 30684565 157 IFRDEYQGLALSAVSTAWGIGLIIGPAIGGFLAQ 190
Cdd:cd17502 111 LVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTD 144

MFS_OAT

cd17374

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...

86-180

2.11e-05

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 46.51 E-value: 2.11e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  86 FMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLG-SFNGLLGPIKAYAMEIFRDEYQG 164
Cdd:cd17374  44 FMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGfAVSGISINTLILGTEWTTPRHRA 123

                        90
                ....*....|....*.
gi 30684565 165 LALSAVSTAWGIGLII 180
Cdd:cd17374 124 LAITLTSCFFSIGQML 139

MFS_FsR

cd17478

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...

38-187

2.97e-05

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 46.01 E-value: 2.97e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  38 LFTVWIIVLCTALPISSLFPFLYFMIddfniaKKEEDIGFYAGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASV 117
Cdd:cd17478 197 LLLLLIIVFLRSWVLSSLTTFLPFYL------VQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLA 270

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 30684565 118 VVFNTLFgLSLNFWMAIITRFCLGSFNGLLGP-IKAYAMEIFRdEYQGLAlSAVST--AWGIGLIIGPAIGGF 187
Cdd:cd17478 271 APFLLLF-LLTPGIWSYILLVLAGFLLFASFPvTVVLAQELLP-GNVGLA-SGLMMglSFGLGGIGAPVLGAL 340

MFS_SV2_like

cd17316

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...

41-189

3.24e-05

Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 46.06 E-value: 3.24e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  41 VWIIVLCTALP---ISSLFPFLYFMIDDFNIAKkeedIGFYAGFVGCSFMLGraftSVAWGLVADRYGRKPVILIGTASV 117
Cdd:cd17316 182 LILLWFFISFGyygLTTFLPTYLQTVLGLSPAT----SSLYLLLISLGALVG----ALIAGLLSDRIGRKKTLVIGLILS 253

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 30684565 118 VVFNTLFGLSL--NFWMAIITRFCLGSFNGLL-GPIKAYAMEIFRDEYQGLALSAVSTAWGIGLIIGPAIGGFLA 189
Cdd:cd17316 254 GILALPLFYLLsgSPTLLLLLLFILSFFVGGVwGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLL 328

MFS_PcaK_like

cd17365

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...

79-189

3.47e-05

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 45.65 E-value: 3.47e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  79 AGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFclgsFNGL-LGPIKAYAMEI 157
Cdd:cd17365  36 LGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRF----LTGLgLGAAMPNAITL 111

                        90       100       110
                ....*....|....*....|....*....|....
gi 30684565 158 FRdEY--QGLALSAVSTAWgIGLIIGPAIGGFLA 189
Cdd:cd17365 112 VS-EYapARRRSLAVTLMF-CGYPLGAALGGFLA 143

MFS_SLC22A7_OAT2

cd17447

Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ...

86-185

6.24e-05

Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341005 [Multi-domain] Cd Length: 341 Bit Score: 45.11 E-value: 6.24e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  86 FMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGS-FNGLLGPIKAYAMEIFRDEYQG 164
Cdd:cd17447  44 FFAGVTMGAVAFGYLSDRFGRKRMLLVAYVLSLVFGLASAFSVSYVMFAITRTLTGFaLTGFSIISMVLCVEWVDIEHRT 123

                        90       100
                ....*....|....*....|.
gi 30684565 165 LALSAVSTAWGIGLIIGPAIG 185
Cdd:cd17447 124 VAGVLISLFWTVGNMLLALVA 144

MFS_YajR_like

cd17472

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...

86-471

6.90e-05

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 44.90 E-value: 6.90e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  86 FMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGSfngllGPIKAYAM----EIFRDE 161
Cdd:cd17472  41 YGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGS-----GAISSVVMallaDLTREE 115

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 162 YQGLALSAVSTAWGIGLIIGPAIGGFLAQpakqypslfsqdsIFGKFPFFLPCLAISVFAFLVTIvssripetlhnhkfn 241
Cdd:cd17472 116 NRTKAMALIGASIGIAFAISMVLGPLLAA-------------HLGVSGLFLITAILSLVSLLILL--------------- 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 242 ddesydALKDLSDDPESNKVAERNGKSSLLNNWPLISSIIVycVFSLHDMAyteiFSLWANSPRKYGGLGYSTADVGSVL 321
Cdd:cd17472 168 ------FFVPDPPKIVQISEKEKKKLKKLLKNKRLLRLDFS--IFILHFVL----MAFFYILPLLLTQLGGGKGQLWKVY 235

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 322 A---FSGFGLLIFqLSLYSYAERLLGPIIVtriSGSLAMVVLSCYPLIAKLSGLALTVTVTSASVAKSVLGTSAITglfi 398
Cdd:cd17472 236 LpaiLIGFILMVP-FVIYAEKKGKMKQVFV---SSILLIAVGFLLLLFAATSLWLLIIGLIIFFIGFNLLEALLPS---- 307

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 30684565 399 LQNKAVRQDQRGAANGIAMTAMSLFKAIGPAAAGIIFSwsekrqgaaFLPGTQMVFFILNVVLALGVVLTFKP 471
Cdd:cd17472 308 LVSKIAPKEYRGTAMGIYNTSQFLGSFLGGALGGLLWG---------LLGYSSVFLTILILALLWLLVSFLLP 371

MFS_ShiA_like

cd17369

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...

78-178

7.33e-05

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 44.83 E-value: 7.33e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  78 YAGFVGCSFMlgrAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSL---NFWMAIITRFCLGSF--NGLLGPIKA 152
Cdd:cd17369 268 LAVLIASVVA---AITIPLFGWLSDRVGRRPVYLAGALLAALFAFPFFWLLdtgSTWLIVLAAVVVLGVlhGMMYGPQAA 344

                        90       100
                ....*....|....*....|....*....
gi 30684565 153 YAMEIF--RDEYQGLALSA-VSTAWGIGL 178
Cdd:cd17369 345 FLAELFptRVRYTGASLGYqLGAILGGGF 373

MFS_MMR_MDR_like

cd17504

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...

43-469

9.55e-05

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 44.49 E-value: 9.55e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  43 IIVLCTALPISSLFPFLYFMIDDFNIAKKEedigfyAGFVGCSFML-GRAFTSVAwGLVADRYGRKPVILIGTASVVVFN 121
Cdd:cd17504   3 LAALAVMLVETMLSPALPTIQREFGTSAAA------VSWVLTAYLLvGAVSTPIL-GRLGDLYGRKKVLLIVLAIYTAGS 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 122 TLFGLSLNFWMAIITRFCLGSFNGLLgPIkAYAM--EIFRDEYQGLALSAVSTAWGIGLIIGPAIGGFLAQpakqypsLF 199
Cdd:cd17504  76 LLAAFAPNLPVLIAGRALQGIGGAVF-PL-AFALvrEEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQ-------HL 146

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 200 SQDSIFgkfpfflpcLAISVFAFLVTIVSSRIPETLHNHKfnddesydalkdlsddpesnkvaerngkssllnNWPLISS 279
Cdd:cd17504 147 GWRWIF---------WTAAPVAVLLAALVPLIDLRLLRRR---------------------------------NVLLANI 184

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 280 IIVYCVFSLHDMAYTEIFSLWANSPrkyGGLGYSTADVGSVLAFSGFGLLIFQLsLYSYAERLLGPIIVTRIsgSLAMVV 359
Cdd:cd17504 185 TALLAGFGMFMVFQLLPQLLQLPTP---TGFGLGITEAGLLLLPGALVMLIAGP-LAGRLIARVGPRRVLLI--GLVISA 258

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 360 LSCYPLIAKLSGLALTVTVTSASVAKSVLGTSAITGLFILqnkAVRQDQRGAANGIAMTAMSLFKAIGPAAAGIIFSWSE 439
Cdd:cd17504 259 VGLLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVE---SVPPDRTGIATGMNTVLRTIGSAIGPAIAGAILTTYT 335

                       410       420       430
                ....*....|....*....|....*....|...
gi 30684565 440 KRQGAAFLP---GTQMVFFILNVVLALGVVLTF 469
Cdd:cd17504 336 VSITSGGVPtegAYVLAFLIGAALALAALLLSL 368

MFS_GLUT_like

cd17315

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...

78-146

1.13e-04

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 44.10 E-value: 1.13e-04

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 30684565  78 YAGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGSFNGL 146
Cdd:cd17315  35 LQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLGVGL 103

Sugar_tr

pfam00083

Sugar (and other) transporter;

73-234

1.24e-04

Sugar (and other) transporter;

Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 44.19 E-value: 1.24e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565    73 EDIGFYAGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLS---LNFWMAIITRFCLGSFNGLLGP 149
Cdd:pfam00083  42 AALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAkgkWSVYQLIVGRVLVGIGVGGASV 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565   150 I-KAYAMEIFRDEYQGLALSAVSTAWGIGLIIGPAIGGFLAqpakqypslFSQDSIFGKFPFFLpclaISVFAFLVTIVS 228
Cdd:pfam00083 122 LaPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGLGLN---------KTSNSDGWRIPLGL----QLVPALLLIIGL 188


                  ....*.
gi 30684565   229 SRIPET 234
Cdd:pfam00083 189 LFLPES 194

efflux_Bcr_CflA

TIGR00710

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...

85-188

1.28e-04

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.

Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 44.30 E-value: 1.28e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565    85 SFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFcLGSFNGLLGPIKAYAMeiFRDEYQG 164
Cdd:TIGR00710  48 LYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRF-VQAFGASAGSVISQAL--VRDIYPG 124

                          90       100
                  ....*....|....*....|....
gi 30684565   165 LALSAVSTAWGIGLIIGPAIGGFL 188
Cdd:TIGR00710 125 EELSRIYSILMPVLALAPAVAPLL 148

MFS_TRI12_like

cd06179

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...

97-190

1.83e-04

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 43.77 E-value: 1.83e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  97 WGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGSFNGLLGPIKAYAMEIFRDEYQGLALSAVSTAWGI 176
Cdd:cd06179  52 VGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALIGIGAGTQGLGAAVASELVPNKYRGLVQGVVNLVASP 131

                        90
                ....*....|....
gi 30684565 177 GLIIGPAIGGFLAQ 190
Cdd:cd06179 132 GSALGPLIAGALVE 145

MFS_SLC22A16_CT2

cd17375

Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major ...

86-214

2.38e-04

Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 16 (SLC22A16) is also called carnitine transporter 2 (CT2), fly-like putative transporter 2 (FLIPT2), organic cation transporter OKB1, or organic cation/carnitine transporter 6 (OCT6). It is a partially sodium-ion dependent high affinity carnitine transporter. It also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. It is one of several organic cation transporters (OCTs) that falls into the SLC22 (solute carrier 22) family. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. SLC22A16 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340933 [Multi-domain] Cd Length: 341 Bit Score: 43.20 E-value: 2.38e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  86 FMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGSF-NGLLGPIKAYAMEIFRDEYQG 164
Cdd:cd17375  44 FMLGVLLGAVIFGDIADRIGRRPVLWFTSTGQFVFGIAVAFTFDYYSFVIVRFLLAMVsSGYLVVVFVYVTEFTGIKART 123

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 30684565 165 LALSAVSTAWGIGLIIgPAIGGFLAQPAKQYPSLFSQDSIfgkfPFFLPC 214
Cdd:cd17375 124 WASMHVHAFFAVGIMV-VALVGYLVRTWWIYQIILSLVTI----PFILCC 168

MFS_PcaK_like

cd17365

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...

79-199

2.88e-04

Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 42.96 E-value: 2.88e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  79 AGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLN-FWMAIITRFCLGSF-NGLLGPIKAYAME 156
Cdd:cd17365 208 ALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAVSLALLGVSPAsLVLLYVLVFLAGACvNGAQVGLYALAAR 287

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 30684565 157 IFRDEYQGLALSAVSTAWGIGLIIGPAIGGFLAQPAKQYPSLF 199
Cdd:cd17365 288 FYPTEVRATGVGWALGVGRLGAILGPLLGGLLLAAGLGPESVF 330

MFS_SLC46

cd17386

Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ...

91-226

3.47e-04

Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340944 [Multi-domain] Cd Length: 360 Bit Score: 42.65 E-value: 3.47e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  91 AFTSVAWGLVADRYGRKPVILIG------TASVVVFNTLFGLSLNFWMAIITRF---CLGSFNGLLGPIKAYAMEIFRDE 161
Cdd:cd17386  44 LFSSLFLGSWSDRYGRKPPLLMSlvglllSSLILVLIVYFTTVPSVWWFYLSAIplaLFGGFTAFLSASFAYISDISSEK 123

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 162 YQGLALSAVSTAWGIGLIIGPAIGGFLAQpAKQYPSLFSQDSIFGKFP-----FFLPCLAISVFAFLVTI 226
Cdd:cd17386 124 KRTYRMAILEVALGLGGFLGSLLSGHLFK-ALGYAWSFSISAALLLIAllyilFFLTLLILLLLAAFLTI 192

MFS_Set

cd17471

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...

96-223

5.45e-04

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 42.15 E-value: 5.45e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  96 AWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGSFNGLLGPIkayAMEIFRD---EYQGLALSAVST 172
Cdd:cd17471 254 LAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNAIFIGITAGL---GISYFQDlmpGQPGLATTLYSN 330

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 30684565 173 AWGIGLIIGPAIGGFLAQpakqypslfsqdsIFGKFPFFLPCLAISVFAFL 223
Cdd:cd17471 331 ASRIGSLLGGLLAGVIAQ-------------YFGYRAVFLVCAVLALLALV 368

2A0115

TIGR00895

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...

79-189

5.79e-04

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]

Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 41.96 E-value: 5.79e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565    79 AGFVGCSFMLGRAFTSVAWGLVADRYGRKPV----ILIGTASVVVFNTLFglslNFWMAIITRFCLGSF-NGLLGPIKAY 153
Cdd:TIGR00895 287 AATGGALFNFGGVIGSIIFGWLADRLGPRVTalllLLGAVFAVLVGSTLF----SPTLLLLLGAIAGFFvNGGQSGLYAL 362

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 30684565   154 AMEIFRDEYQGlalSAVSTAWGIG---LIIGPAIGGFLA 189
Cdd:TIGR00895 363 MALFYPTAIRA---TGVGWAIGIGrlgAIIGPILAGYLL 398

MFS_GLUT_Class1_2_like

cd17357

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...

92-234

6.43e-04

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 42.25 E-value: 6.43e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  92 FTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNF-----WMAI--ITRFCL--GSFNGLLGPIKAYAM-EIFRDE 161
Cdd:cd17357 308 LSTIVGPFLIEKVGRRPLLLISLSVCAVALLLMSVFLFLseqnsWMSYgcIVAIFLfiFFFAIGLGPIPWFIGaELFPQA 387

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 30684565 162 YQGLALS-AVSTAWGIGLIIGPAiggflaqpakqYPSLFSQDSIFgkfpFFLPCLAISVFAFLVTIVssRIPET 234
Cdd:cd17357 388 PRSAAQSlGSSVNWTSNFIVGMA-----------FPPLQSIGGGF----VFIIFAIPCALFLLYLYR--YLPET 444

MFS_Set

cd17471

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...

43-190

7.28e-04

Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 41.76 E-value: 7.28e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  43 IIVLCTALPISSLFPFL-YFMIDDFNIAKkeedigFYAGFVGCSFMLGRAFTSVAWGLVADR-YGRKPVILIGTASVVVF 120
Cdd:cd17471   3 LATLLTGLAGAFVLPYLsLFLTEELGASP------LQIGIFMTLSALSGIVVSQWLGRLSDRgGDRKPLILLALLAGALG 76

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 30684565 121 NTLFGLSLNFWMAIITRFCLGSFNGLLGP-IKAYAMEIF---RDEYQGLALSAVSTAWGIGLIIGPAIGGFLAQ 190
Cdd:cd17471  77 YLLFAFLRNYWVLLLVGVVLLSLGAAAFPqLFALAREYAdrsSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLD 150

MFS_arabinose_efflux_permease_like

cd17473

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...

88-196

8.42e-04

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 41.40 E-value: 8.42e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  88 LGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGSFNGLLGPIkayAMEIFRDEYQGLA- 166
Cdd:cd17473  46 LFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTL---ATALIGDYFEGEEr 122

                        90       100       110
                ....*....|....*....|....*....|...
gi 30684565 167 ---LSAVSTAWGIGLIIGPAIGGFLAQPAKQYP 196
Cdd:cd17473 123 akmLGLQSAAMSLGGVVFLLLGGALAEIGWRAP 155

MFS_MdtG_MDR_like

cd17391

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...

33-189

8.89e-04

Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 41.48 E-value: 8.89e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  33 FPFWELFTVWIIVLCTALPISslfPFLYFMIDDfnIAKKEEDIGFYAGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILI 112
Cdd:cd17391 201 SLLISLFVTTFIIQLANQSIE---PILTLYIRQ--LMGDASNLAFISGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLG 275

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 30684565 113 GTASVVVFNTLFGLSLNFWMAIITRFCLG-SFNGLLGPIKAYAMEIFRDEYQGLALSAVSTAWGIGLIIGPAIGGFLA 189
Cdd:cd17391 276 ALLASALLYIPQAFVQTPWQLGILRFLLGlATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIA 353

MFS_MosC_like

cd17393

Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ...

28-190

1.09e-03

Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 41.09 E-value: 1.09e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  28 RLRRGFPFWELFTVWIIVLCTALPISSLFPFL-YFMIDDFNIAKKEEDIGfYAGFVGCSFMlGRAFTsvawGLVADRYGR 106
Cdd:cd17393 191 KPGFLLPNRLLLLLGLLALAAALAEGAAADWSaLYLRDVLGASAALAALG-YAVFSLAMTV-GRLFG----DRLVDRFGD 264

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 107 KPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLG-----------SFNGLLGPIKAyameifrdeyqGLALSAVSTAWG 175
Cdd:cd17393 265 VAVLRAGALLAALGLLLALLAPSVWVALAGFALMGlglsvvvplafSAAGALPGLAA-----------GIAVARVATLGY 333

                       170
                ....*....|....*
gi 30684565 176 IGLIIGPAIGGFLAQ 190
Cdd:cd17393 334 LGFLVGPPLIGFLAD 348

MFS_SLC22A1_2_3

cd17379

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...

88-188

3.11e-03

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340937 [Multi-domain] Cd Length: 340 Bit Score: 39.64 E-value: 3.11e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  88 LGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGSFnGLLGPIKAYAM--EIFRDEYQGL 165
Cdd:cd17379  44 LGFLIGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFLQGLF-GKGGWMTGYVLvtEFVGSKYRRT 122

                        90       100
                ....*....|....*....|...
gi 30684565 166 ALSAVSTAWGIGLIIGPAIGGFL 188
Cdd:cd17379 123 VGIVYQMFFTLGLLILPGIAYFI 145

MFS_SLC22A15

cd17377

Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ...

95-145

3.38e-03

Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340935 [Multi-domain] Cd Length: 353 Bit Score: 39.76 E-value: 3.38e-03

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 30684565  95 VAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGSFNG 145
Cdd:cd17377  57 VSFGQLSDRFGRKPVYLTGLALDILFAYFNALAPSYEFFAVSRFLVGVMNG 107

PRK10489

enterobactin transporter EntS;

98-188

3.58e-03

enterobactin transporter EntS;

Pssm-ID: 236700 [Multi-domain] Cd Length: 417 Bit Score: 39.58 E-value: 3.58e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565   98 GLVADRYGRKPVILIGTASVVVFntLFGLSLNFWM---AIITRFCLGSFNGLLGPIKAYAME------IFRDEY-QGLAL 167
Cdd:PRK10489  73 GVLADRYDRKKLILLARGTCGLG--FIGLALNAFLpepSLLAIYLLGLWDGFFGSLGVTALLaatpalVGRENLmQAGAI 150

                         90       100
                 ....*....|....*....|.
gi 30684565  168 SAVSTAwgIGLIIGPAIGGFL 188
Cdd:PRK10489 151 TMLTVR--LGSVISPALGGLL 169

2A0104

TIGR00881

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...

60-234

3.74e-03

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]

Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 39.67 E-value: 3.74e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565    60 YFMIDDFNIAKKE--EDIGFYA---GFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAI 134
Cdd:TIGR00881   8 YLVRKNFALAMPYlvEEIGLSKtdlGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMA 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565   135 ITRFCLGSFNGLLGPIKAYAMEIFRDEYQ-GLALSAVSTAWGIGLIIGPAIGGFLAQpakqypSLFSQDSIFgkfpFFLP 213
Cdd:TIGR00881  88 ALWALNGIFQGMGWPPCGRTVTKWFSRSErGTWVSFWNCSHNVGGGLLPPLVLFGIA------ELYSWHWVF----IVPG 157

                         170       180
                  ....*....|....*....|.
gi 30684565   214 CLAIsVFAFLVTIVSSRIPET 234
Cdd:TIGR00881 158 IIAI-IVSLICFLLLRDSPQS 177

MFS_SLC18B1

cd17385

Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ...

35-188

4.50e-03

Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340943 [Multi-domain] Cd Length: 390 Bit Score: 39.12 E-value: 4.50e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  35 FWELFT---VWIIVLC---TALPISSLFPFLYFMIDDFNiakkeedigFYAGFVGCSFMLG---RAFTSVAWGLVADRYG 105
Cdd:cd17385 194 MLKLLKipsVLLLCLSivsGSVSLGFLDPTLSPHLRQFK---------LSPGQVGLMFLILagsYAISAPLWGWLSDKKK 264

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 106 -RKPVILIGTASVVVFNTLFG------LSLNFWMAIITRFCLG---------SFNGLLGPIKAYAMEifrDEY--QGLAL 167
Cdd:cd17385 265 iPKWLMVIGSIITGVGFLLLGpapllpIKSELWMVIIGLVLLGlslgaalvpTFPELLNCAREYGFP---DNLstYGLVS 341

                       170       180
                ....*....|....*....|.
gi 30684565 168 SAVSTAWGIGLIIGPAIGGFL 188
Cdd:cd17385 342 GLFNAAFSLGAFIGPTLGGFL 362

MFS_arabinose_efflux_permease_like

cd17473

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...

79-224

5.54e-03

Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 39.09 E-value: 5.54e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  79 AGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGSFNGLLGP-IKAYAMEI 157
Cdd:cd17473 235 IGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPtLNSWAMSL 314

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 30684565 158 FRDEYQGLALSAVSTAWGIGLIIGPAIGGFLAQPAKQYPSLFsqdSIFGKFpfflpCLAISVFAFLV 224
Cdd:cd17473 315 VPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGAF---LILGVL-----ALVLAIVLLLL 373

MFS_YdiM_like

cd17396

Inner membrane transport protein YdiM and similar proteins of the Major Facilitator ...

81-436

5.54e-03

Inner membrane transport protein YdiM and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily contains Escherichia coli inner membrane transport proteins YdiM and YdiN, which belong to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340954 [Multi-domain] Cd Length: 384 Bit Score: 38.87 E-value: 5.54e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  81 FVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFntLFG--LSLNFWMAIITRFCLGSFNGLLGPIKAYA-MEI 157
Cdd:cd17396  39 YVISGIGIGRLLTILFAGVLSDKFGRKPSVLLGMVLYALF--FVGilFSPNLIIAYVFALLAGAANSFLDTGTYPAlMEA 116

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 158 FRdEYQGLALSAVSTAWGIGLIIGPAIGGFLAqpakqypslfsQDSIFGKFPFFLPcLAISVFAFLVTIVSSRIPETLhn 237
Cdd:cd17396 117 FP-KASGSANILVKAFVSFGQFLLPFIIAFLA-----------ANNLWYGWSFIVP-AAVLVLNALLLLKLSFPPQTV-- 181

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 238 hkfnddesydalkdlsdDPESNKVAERNGKSSLLNNWPLISSIIVYCVFSlhdmayTEIFSLWANSPRKYGG--LGYSTA 315
Cdd:cd17396 182 -----------------TAANTKQKEIPVKREKPKFLIEGIALILIGFTS------TATFYLFSQWMPKYGSavAGMGEA 238

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 316 DVGSVLAFSGFGLLIFQLSLYSYAERLLGPIIVTRIsgslamvvlscYPLIAKLSgLALTVTVTSASVAKS---VLGTSA 392
Cdd:cd17396 239 ESLKLISYYSMGSLVCVFITAVLLKRYVRPIWILVL-----------YPIISLLA-LFVLYLVPSPDVCILgafVIGFFA 306

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*..
gi 30684565 393 ITGLFILQNKAVRQ---DQRGAANGIAMTAMSLFKAIGPAAAGIIFS 436
Cdd:cd17396 307 AGGVLQLGLTLMAEffpKGKGKVTGIYMIASSLANFVIPLITGIIAS 353

MFS_FucP_MFSD4_like

cd17333

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...

41-188

6.10e-03

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 38.84 E-value: 6.10e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  41 VWIIVLCTALPISSLFPFLYFMIDDFNIAKKEedigfyAGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVF 120
Cdd:cd17333   1 LYISFFSNGLTDALLGILGPSLEEAFNLNVAD------VSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLA 74

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 30684565 121 NTLFGLSLNFWMAIITRFCLGSFNGLLGPI-KAYAMEIFrDEYQGLALSAVSTAWGIGLIIGPAIGGFL 188
Cdd:cd17333  75 LALIFATPSIYLFVVLMFLAGLGAGILDTGaNTFVGALF-EESSATRLNVLHGFFGLGALIGPLIATSL 142

MFS_GLUT6_8_Class3_like

cd17358

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...

84-234

7.64e-03

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 38.71 E-value: 7.64e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  84 CSFMLG--RAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWM--------AIITRFCL----GSFNGLLGP 149
Cdd:cd17358 279 ATIIIGvvQVVGTLVATLLVDRLGRRPLLLVSAIGMGIGLLALGLYFYLQEhgallssvSWLPLVGLviyiISFSIGLGP 358

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565 150 IKAYAM-EIFRDEYQGLALS-AVSTAWGIGLIIgpaiggflaqpAKQYPSLFSQDSIFGKFPFFlpcLAISVFAFLVTIV 227
Cdd:cd17358 359 LPWVIMsEIFPAKIKGLAGSlVTLVNWLFAFIV-----------TKTFPFLTLAWGASGTFWIF---AGICGLALVFVLL 424


                ....*..
gi 30684565 228 SsrIPET 234
Cdd:cd17358 425 F--VPET 429

MFS_XylE_like

cd17359

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...

61-141

7.79e-03

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 38.32 E-value: 7.79e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  61 FMIDDFNIAKKEEdigfyaGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIgtASVVVFNTLFG--LSLNFWMAIITRF 138
Cdd:cd17359  26 FLQTDFNLTPFLE------GLVVSSALLGAAIGALFAGRLADRFGRRKTLLI--SAVLFFISALGsaFSPNFTIFIIARI 97


                ...
gi 30684565 139 CLG 141
Cdd:cd17359  98 IGG 100

MFS_SLC17A9_like

cd17380

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...

48-149

8.22e-03

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 38.30 E-value: 8.22e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  48 TALPISSLFpflyfMIDDFNIAKKEedigfyAGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTA--SVVVFNTLFG 125
Cdd:cd17380  16 VNMPIAIVP-----MAKEFGWSKTD------QGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVAlwSLATLLTPLL 84

                        90       100
                ....*....|....*....|....
gi 30684565 126 LSLNFWMAIITRFCLGSFNGLLGP 149
Cdd:cd17380  85 AYSSLPLLILSRILLGLGEGVHFP 108

MFS_Amf1_MDR_like

cd17476

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...

97-192

9.52e-03

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 38.01 E-value: 9.52e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565  97 WGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGSFNGLLGPikaYAMEIFRDEYQG-----LALSAVS 171
Cdd:cd17476  53 FGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRALQGLGPAFLLP---NAMALLGRTYPPgprknIVFSLFG 129

                        90       100
                ....*....|....*....|.
gi 30684565 172 TAWGIGLIIGPAIGGFLAQPA 192
Cdd:cd17476 130 ATAPLGFALGGVFGGLFAQLA 150

emrD

PRK11652

multidrug transporter EmrD;

97-235

9.79e-03

multidrug transporter EmrD;

Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 38.35 E-value: 9.79e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684565   97 WGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGSFNGLLGpikAYAMEIFRDEYQGLAL----SAVST 172
Cdd:PRK11652  63 YGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIQGLGTGVGG---VMARTLPRDLYEGTQLrhanSLLNM 139

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 30684565  173 AWGIGLIIGPAIGGFLAqpakqypSLFSQDSIFgkfpFFLPCLAISVFAFLVTivssRIPETL 235
Cdd:PRK11652 140 GILVSPLLAPLIGGLLT-------TLFGWRACY----LFLLLLGAGVTFSMAR----WMPETR 187

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01