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Conserved domains on  [gi|30698018|ref|NP_850974|]
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NHL domain-containing protein [Arabidopsis thaliana]

Protein Classification

NHL repeat-containing protein( domain architecture ID 110303)

NHL (NCL-1, HT2A and LIN-41) repeat-containing protein may have a catalytic activity or interact with other proteins; NHL is a six-bladed beta-propeller

CATH:  2.40.10.500
Gene Ontology:  GO:0005515
PubMed:  9868369|17979191

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NHL super family cl18310
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 23-164 2.17e-25

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


The actual alignment was detected with superfamily member cd14953:

Pssm-ID: 302697 [Multi-domain]  Cd Length: 323  Bit Score: 105.69  E-value: 2.17e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698018  23 PYSIEVLPNGELLILDSENSNIYKISSSlslysrpRLVT---GSPE-GYPGhvDGRLRDAKLNHPKGLTVDDRGNIYVAD 98
Cdd:cd14953  79 PSGVAVDAAGNLYVADTGNHRIRKITPD-------GVVStlaGTGTaGFSD--DGGATAAQFNYPTGVAVDAAGNLYVAD 149

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 30698018  99 TVNNAIRKISEGG-VTTIAGgkTVRNGGHVDGPSEDAKFSNDFDVVyVGSSCSLLVIDRGNKAIREI 164
Cdd:cd14953 150 TGNHRIRKITPDGvVTTVAG--TGGAGYAGDGPATAAQFNNPTGVA-VDAAGNLYVADRGNHRIRKI 213
 
Name Accession Description Interval E-value
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 23-164 2.17e-25

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 105.69  E-value: 2.17e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698018  23 PYSIEVLPNGELLILDSENSNIYKISSSlslysrpRLVT---GSPE-GYPGhvDGRLRDAKLNHPKGLTVDDRGNIYVAD 98
Cdd:cd14953  79 PSGVAVDAAGNLYVADTGNHRIRKITPD-------GVVStlaGTGTaGFSD--DGGATAAQFNYPTGVAVDAAGNLYVAD 149

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 30698018  99 TVNNAIRKISEGG-VTTIAGgkTVRNGGHVDGPSEDAKFSNDFDVVyVGSSCSLLVIDRGNKAIREI 164
Cdd:cd14953 150 TGNHRIRKITPDGvVTTVAG--TGGAGYAGDGPATAAQFNNPTGVA-VDAAGNLYVADRGNHRIRKI 213
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
20-129 1.32e-09

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 58.88  E-value: 1.32e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698018  20 GIEPYSIEVLPNGELLILDSENSNIYKISSSlslysrprlvTGSPEGYPghvdgrlrDAKLNHPKGLTVDDRGNIYVADT 99
Cdd:COG4257  16 GSGPRDVAVDPDGAVWFTDQGGGRIGRLDPA----------TGEFTEYP--------LGGGSGPHGIAVDPDGNLWFTDN 77

                        90       100       110
                ....*....|....*....|....*....|....
gi 30698018 100 VNNAIRKIS--EGGVTTIAGGKTVRN--GGHVDG 129
Cdd:COG4257  78 GNNRIGRIDpkTGEITTFALPGGGSNphGIAFDP 111
PLN02919 PLN02919
haloacid dehalogenase-like hydrolase family protein
 22-170 1.40e-09

haloacid dehalogenase-like hydrolase family protein


Pssm-ID: 215497 [Multi-domain]  Cd Length: 1057  Bit Score: 60.25  E-value: 1.40e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698018    22 EPYSIEVLPN-GELLILDSENSNIykisSSLSLYSR-PRLVTGSPEGYP------GHVDGRLRDAKLNHPKGLTVDDRGN 93
Cdd:PLN02919  741 QPSGISLSPDlKELYIADSESSSI----RALDLKTGgSRLLAGGDPTFSdnlfkfGDHDGVGSEVLLQHPLGVLCAKDGQ 816

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698018    94 IYVADTVNNAIRKI--SEGGVTTIAG-GKtvrnGGHVDGPSEDAKFSNDFDVVyVGSSCSLLVIDRGNKAIREIQLHFDD 170
Cdd:PLN02919  817 IYVADSYNHKIKKLdpATKRVTTLAGtGK----AGFKDGKALKAQLSEPAGLA-LGENGRLFVADTNNSLIRYLDLNKGE 891
NHL pfam01436
NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is ...
 80-106 7.11e-04

NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is about 40 residues long and resembles the WD repeat pfam00400. The repeats have a catalytic activity in Swiss:P10731, proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Swiss:Q13049 interacts with the activation domain of Tat. This interaction is me diated by the NHL repeats.


Pssm-ID: 396153 [Multi-domain]  Cd Length: 28  Bit Score: 36.61  E-value: 7.11e-04
                          10        20
                  ....*....|....*....|....*..
gi 30698018    80 LNHPKGLTVDDRGNIYVADTVNNAIRK 106
Cdd:pfam01436   1 FNRPHGVAVDSNGDIYVADSENHRVQV 27
 
Name Accession Description Interval E-value
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 23-164 2.17e-25

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 105.69  E-value: 2.17e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698018  23 PYSIEVLPNGELLILDSENSNIYKISSSlslysrpRLVT---GSPE-GYPGhvDGRLRDAKLNHPKGLTVDDRGNIYVAD 98
Cdd:cd14953  79 PSGVAVDAAGNLYVADTGNHRIRKITPD-------GVVStlaGTGTaGFSD--DGGATAAQFNYPTGVAVDAAGNLYVAD 149

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 30698018  99 TVNNAIRKISEGG-VTTIAGgkTVRNGGHVDGPSEDAKFSNDFDVVyVGSSCSLLVIDRGNKAIREI 164
Cdd:cd14953 150 TGNHRIRKITPDGvVTTVAG--TGGAGYAGDGPATAAQFNNPTGVA-VDAAGNLYVADRGNHRIRKI 213
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 23-164 1.38e-24

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 103.38  E-value: 1.38e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698018  23 PYSIEVLPNGELLILDSENSNIYKISSSLSlysrprlVT---GSPeGYPGHVDGRLRDAKLNHPKGLTVDDRGNIYVADT 99
Cdd:cd14953 189 PTGVAVDAAGNLYVADRGNHRIRKITPDGV-------VTtvaGTG-TAGFSGDGGATAAQLNNPTGVAVDAAGNLYVADS 260

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 30698018 100 VNNAIRKISEGG-VTTIAGGKTVRNGGhvDGPSEDAKFSNDFDVVyVGSSCSLLVIDRGNKAIREI 164
Cdd:cd14953 261 GNHRIRKITPAGvVTTVAGGGAGFSGD--GGPATSAQFNNPTGVA-VDAAGNLYVADTGNNRIRKI 323
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 23-194 1.59e-22

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 97.60  E-value: 1.59e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698018  23 PYSIEVLPNGELLILDSENSNIYKISSSLSlysrprlVT---GSPeGYPGHVDGRLRDAKLNHPKGLTVDDRGNIYVADT 99
Cdd:cd14953 134 PTGVAVDAAGNLYVADTGNHRIRKITPDGV-------VTtvaGTG-GAGYAGDGPATAAQFNNPTGVAVDAAGNLYVADR 205

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698018 100 VNNAIRKISEGG-VTTIAGGKTVrnGGHVDGPSEDAKFSNDFDVVyVGSSCSLLVIDRGNKAIREIQlhfddcayqygsg 178
Cdd:cd14953 206 GNHRIRKITPDGvVTTVAGTGTA--GFSGDGGATAAQLNNPTGVA-VDAAGNLYVADSGNHRIRKIT------------- 269

                       170
                ....*....|....*.
gi 30698018 179 fPLGIAVLVAAGFFGY 194
Cdd:cd14953 270 -PAGVVTTVAGGGAGF 284
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 23-164 6.29e-21

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 92.98  E-value: 6.29e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698018  23 PYSIEVLPNGELLILDSENSNIYKISSSlslysrpRLVT---GSpeGYPGHVDGRLRDAKLNHPKGLTVDDRGNIYVADT 99
Cdd:cd14953  25 PSGVAVDAAGNLYVADRGNHRIRKITPD-------GVVTtvaGT--GTAGFADGGGAAAQFNTPSGVAVDAAGNLYVADT 95

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 30698018 100 VNNAIRKISEGG-VTTIAGGKTVRNGGhvDGPSEDAKFSNDFDVVyVGSSCSLLVIDRGNKAIREI 164
Cdd:cd14953  96 GNHRIRKITPDGvVSTLAGTGTAGFSD--DGGATAAQFNYPTGVA-VDAAGNLYVADTGNHRIRKI 158
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 66-164 6.35e-21

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 92.98  E-value: 6.35e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698018  66 GYPGHVDGRLRDAKLNHPKGLTVDDRGNIYVADTVNNAIRKIS-EGGVTTIAGGKTvrnGGHVDGPSEDAKFSNDFDVVy 144
Cdd:cd14953   8 GTAGFSGGGGTAARFNSPSGVAVDAAGNLYVADRGNHRIRKITpDGVVTTVAGTGT---AGFADGGGAAAQFNTPSGVA- 83

                        90       100
                ....*....|....*....|
gi 30698018 145 VGSSCSLLVIDRGNKAIREI 164
Cdd:cd14953  84 VDAAGNLYVADTGNHRIRKI 103
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 15-185 2.54e-15

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 75.82  E-value: 2.54e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698018  15 DGSKLG--IEPYSIEVLPNGELLILDSENSNIYKISSSlslySRPRLVTGSPEGYPGhvdgrlrdaKLNHPKGLTVDDRG 92
Cdd:cd05819  47 FGSGDGqfNEPAGVAVDSDGNLYVADTGNHRIQKFDPD----GNFLASFGGSGDGDG---------EFNGPRGIAVDSSG 113

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698018  93 NIYVADTVNNAIRKI-SEGGVTTIAGGKTvrngghvdgpSEDAKFSNDFDVVyVGSSCSLLVIDRGNKAIR------EIQ 165
Cdd:cd05819 114 NIYVADTGNHRIQKFdPDGEFLTTFGSGG----------SGPGQFNGPTGVA-VDSDGNIYVADTGNHRIQvfdpdgNFL 182

                       170       180
                ....*....|....*....|..
gi 30698018 166 LHFDDcAYQYGSGF--PLGIAV 185
Cdd:cd05819 183 TTFGS-TGTGPGQFnyPTGIAV 203
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 22-164 2.93e-15

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 75.43  E-value: 2.93e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698018  22 EPYSIEVLPNGELLILDSENSNIYKISSSlslySRPRLVTGSPEGYPGhvdgrlrdaKLNHPKGLTVDDRGNIYVADTVN 101
Cdd:cd05819 150 GPTGVAVDSDGNIYVADTGNHRIQVFDPD----GNFLTTFGSTGTGPG---------QFNYPTGIAVDSDGNIYVADSGN 216

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 30698018 102 NAIRKISEGGVTTIAGGKTVRNGGHVDGPSEdakfsndfdvVYVGSSCSLLVIDRGNKAIREI 164
Cdd:cd05819 217 NRVQVFDPDGAGFGGNGNFLGSDGQFNRPSG----------LAVDSDGNLYVADTGNNRIQVF 269
NHL-2_like cd14951
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL ...
 30-166 4.54e-15

NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL repeat-containing protein 2 (NHLRC2) and related bacterial proteins; members of this eukaryotic and bacterial family are uncharacterized, the NHL repeat domain is found C-terminally of a thioredoxin domain. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271321 [Multi-domain]  Cd Length: 334  Bit Score: 76.08  E-value: 4.54e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698018  30 PNGELLILDSENSNIYKIS----SSLSLYSRPRLVTGSPEGypGHVDGRLRDAKLNHPKGLTVDDRGNIYVADTVNNAIR 105
Cdd:cd14951 143 GWGELFVADSESSAIRAVSlkdgGVKTLVGGTRVGTGLFDF--GDRDGPGAEALLQHPLGVAALPDGSVYVADTYNHKIK 220

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 30698018 106 KI--SEGGVTTIAGGKTVrngGHVDGPsedAKFSNDFDVVYVGSScSLLVIDRGNKAIREIQL 166
Cdd:cd14951 221 RVdpATGEVSTLAGTGKA---GYKDLE---AQFSEPSGLVVDGDG-RLYVADTNNHRIRRLDL 276
NHL-2_like cd14951
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL ...
 62-144 4.89e-15

NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL repeat-containing protein 2 (NHLRC2) and related bacterial proteins; members of this eukaryotic and bacterial family are uncharacterized, the NHL repeat domain is found C-terminally of a thioredoxin domain. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271321 [Multi-domain]  Cd Length: 334  Bit Score: 75.69  E-value: 4.89e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698018  62 GSPEgyPGHVDGRLRDAKLNHPKGLTVDDRGNIYVADTVNNAIRKI--SEGGVTTIAG-GK--TVRNGGhvdGPSEDAKF 136
Cdd:cd14951   2 GSGE--RGLKDGSFAEASFNEPQGLALLPGNILYVADTENHALRKIdlETGTVTTLAGtGEqgRDGEGG---GPGREQPL 76


                ....*...
gi 30698018 137 SNDFDVVY 144
Cdd:cd14951  77 SSPWDVAW 84
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 23-185 3.99e-14

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 72.35  E-value: 3.99e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698018  23 PYSIEVLPNGELLILDSENSNIYKIssslslysrprlvtgSPEGYPGHVDGRL--RDAKLNHPKGLTVDDRGNIYVADTV 100
Cdd:cd05819  10 PQGIAVDSSGNIYVADTGNNRIQVF---------------DPDGNFITSFGSFgsGDGQFNEPAGVAVDSDGNLYVADTG 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698018 101 NNAIRKISEGGVTTIAGGKTVRNGGHVDGPSedakfsndfdVVYVGSSCSLLVIDRGNKAIREiqlhFDD---CAYQYGS 177
Cdd:cd05819  75 NHRIQKFDPDGNFLASFGGSGDGDGEFNGPR----------GIAVDSSGNIYVADTGNHRIQK----FDPdgeFLTTFGS 140

                       170
                ....*....|....*.
gi 30698018 178 G--------FPLGIAV 185
Cdd:cd05819 141 GgsgpgqfnGPTGVAV 156
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 8-185 1.36e-12

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 67.68  E-value: 1.36e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698018   8 YSVETVFDGSKLGIEPYSIEVLPNGELLILDSENSNIyKISSSLSLYSRPRLVTGSPEGYpghvdgrlrdakLNHPKGLT 87
Cdd:cd14957  52 YSIGSGGTGSGQFNSPYGIAVDSNGNIYVADTDNNRI-QVFNSSGVYQYSIGTGGSGDGQ------------FNGPYGIA 118

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698018  88 VDDRGNIYVADTVNNAIRKISEGGVTTIAGGKTVRNGGHVDGPSEdakfsndfdvVYVGSSCSLLVIDRGNKAireIQLH 167
Cdd:cd14957 119 VDSNGNIYVADTGNHRIQVFTSSGTFSYSIGSGGTGPGQFNGPQG----------IAVDSDGNIYVADTGNHR---IQVF 185

                       170       180
                ....*....|....*....|....*...
gi 30698018 168 FDDCAYQY---GSGF-------PLGIAV 185
Cdd:cd14957 186 TSSGTFQYtfgSSGSgpgqfsdPYGIAV 213
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
20-129 1.32e-09

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 58.88  E-value: 1.32e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698018  20 GIEPYSIEVLPNGELLILDSENSNIYKISSSlslysrprlvTGSPEGYPghvdgrlrDAKLNHPKGLTVDDRGNIYVADT 99
Cdd:COG4257  16 GSGPRDVAVDPDGAVWFTDQGGGRIGRLDPA----------TGEFTEYP--------LGGGSGPHGIAVDPDGNLWFTDN 77

                        90       100       110
                ....*....|....*....|....*....|....
gi 30698018 100 VNNAIRKIS--EGGVTTIAGGKTVRN--GGHVDG 129
Cdd:COG4257  78 GNNRIGRIDpkTGEITTFALPGGGSNphGIAFDP 111
PLN02919 PLN02919
haloacid dehalogenase-like hydrolase family protein
 22-170 1.40e-09

haloacid dehalogenase-like hydrolase family protein


Pssm-ID: 215497 [Multi-domain]  Cd Length: 1057  Bit Score: 60.25  E-value: 1.40e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698018    22 EPYSIEVLPN-GELLILDSENSNIykisSSLSLYSR-PRLVTGSPEGYP------GHVDGRLRDAKLNHPKGLTVDDRGN 93
Cdd:PLN02919  741 QPSGISLSPDlKELYIADSESSSI----RALDLKTGgSRLLAGGDPTFSdnlfkfGDHDGVGSEVLLQHPLGVLCAKDGQ 816

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698018    94 IYVADTVNNAIRKI--SEGGVTTIAG-GKtvrnGGHVDGPSEDAKFSNDFDVVyVGSSCSLLVIDRGNKAIREIQLHFDD 170
Cdd:PLN02919  817 IYVADSYNHKIKKLdpATKRVTTLAGtGK----AGFKDGKALKAQLSEPAGLA-LGENGRLFVADTNNSLIRYLDLNKGE 891
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 77-185 3.11e-09

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 57.71  E-value: 3.11e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698018  77 DAKLNHPKGLTVDDRGNIYVADTVNNAIRKISEGGVTTIAGGKTVRNGGHVDGPSEdakfsndfdvVYVGSSCSLLVIDR 156
Cdd:cd05819   4 PGELNNPQGIAVDSSGNIYVADTGNNRIQVFDPDGNFITSFGSFGSGDGQFNEPAG----------VAVDSDGNLYVADT 73

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 30698018 157 GNKAIREI--QLHFDDCAYQYGSGF-----PLGIAV 185
Cdd:cd05819  74 GNHRIQKFdpDGNFLASFGGSGDGDgefngPRGIAV 109
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
23-116 1.35e-08

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 55.80  E-value: 1.35e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698018  23 PYSIEVLPNGELLILDSENSNIYKISSSlslysrprlvTGSPEGYPGHvdgrlrdAKLNHPKGLTVDDRGNIYVADTVNN 102
Cdd:COG4257 147 PYGIAVDPDGNLWVTDFGANAIGRIDPD----------TGTLTEYALP-------TPGAGPRGLAVDPDGNLWVADTGSG 209

                        90
                ....*....|....*.
gi 30698018 103 AIRKI--SEGGVTTIA 116
Cdd:COG4257 210 RIGRFdpKTGTVTEYP 225
NHL-2_like cd14951
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL ...
 74-164 3.42e-08

NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL repeat-containing protein 2 (NHLRC2) and related bacterial proteins; members of this eukaryotic and bacterial family are uncharacterized, the NHL repeat domain is found C-terminally of a thioredoxin domain. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271321 [Multi-domain]  Cd Length: 334  Bit Score: 54.89  E-value: 3.42e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698018  74 RLRDAKLNH------PKGLTVDDRGNIYVADTVNNAIRKIS--EGGVTTIAGGktVRNG------GHVDGPSEDAKFSND 139
Cdd:cd14951 121 GNRNGPYPHeawfaqPSGLSLAGWGELFVADSESSAIRAVSlkDGGVKTLVGG--TRVGtglfdfGDRDGPGAEALLQHP 198

                        90       100
                ....*....|....*....|....*
gi 30698018 140 FDVVYVGSScSLLVIDRGNKAIREI 164
Cdd:cd14951 199 LGVAALPDG-SVYVADTYNHKIKRV 222
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 23-107 9.46e-08

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 53.06  E-value: 9.46e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698018  23 PYSIEVLPNGELLILDSENSNIYKISSSlslySRPRLVTGSPegypGHVDGRLRDaklnhPKGLTVDDRGNIYVADTVNN 102
Cdd:cd14956 203 PYGIAIDPDGNVFVADFGNNRIQKFTAD----GTFLTSWGSP----GTGPGQFKN-----PWGVVVDADGTVYVADSNNN 269


                ....*
gi 30698018 103 AIRKI 107
Cdd:cd14956 270 RVQRF 274
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 23-161 3.94e-07

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 51.42  E-value: 3.94e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698018  23 PYSIEVLPNGELLILDSENSNIYKISSSLSLysrprlVT--GSPEGypghvdgrlRDAKLNHPKGLTVDDRGNIYVADTV 100
Cdd:cd14955 159 PTGIAVDSAGNVYVADTGNNRIQKFTSTGTF------LTkwGSEGS---------GDGQFNAPYGIAVDSAGNVYVADTG 223

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 30698018 101 NNAIRKISEGGVTTIAGGktvrNGGHVDGPsedakFSNDFDVVyVGSSCSLLVIDRGNKAI 161
Cdd:cd14955 224 NNRIQKFDSSGTFITKWG----SEGSGDGQ-----FNSPSGIA-VDSAGNVYVADSGNNRI 274
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 77-185 9.15e-07

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 50.27  E-value: 9.15e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698018  77 DAKLNHPKGLTVDDRGNIYVADTVNNAIRKISEGGVTTIAGGktvRNGghvdgpSEDAKFSNDFDVVyVGSSCSLLVIDR 156
Cdd:cd14955  12 DGQFNSPSGIAVDSAGNVYVADTGNNRIQKFDSTGTFLTKWG---SSG------SGDGQFYSPTGIA-VDSDGNVYVADT 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 30698018 157 GNKAIREiqlhFD-DCAYQ-----YGSG-----FPLGIAV 185
Cdd:cd14955  82 GNHRIQK----FDsTGTFLtkwgsSGSGdgqfnSPSGIAV 117
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
12-107 2.10e-06

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 48.86  E-value: 2.10e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698018  12 TVFDGSKLGIEPYSIEVLPNGELLILDSENSNIYKISSSlslysrprlvTGSPEGYPGHVDGrlrdaklNHPKGLTVDDR 91
Cdd:COG4257 179 TEYALPTPGAGPRGLAVDPDGNLWVADTGSGRIGRFDPK----------TGTVTEYPLPGGG-------ARPYGVAVDGD 241

                        90
                ....*....|....*.
gi 30698018  92 GNIYVADTVNNAIRKI 107
Cdd:COG4257 242 GRVWFAESGANRIVRF 257
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 22-158 2.10e-06

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 49.08  E-value: 2.10e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698018  22 EPYSIEVLPNGELLILDSENSNIYKISSSLSLYSrprlVTGSpEGYPGHvdgrlrdaKLNHPKGLTVDDRGNIYVADTVN 101
Cdd:cd14954 166 SPRGVAVNPDGNIVVSDFNNHRLQVFDPDGQFLR----FFGS-EGSGNG--------QFKRPRGVAVDDEGNIIVADSGN 232

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 30698018 102 NAIRKISEGGVTTIAGGKTVRNGGHVDGPSEdakfsndfdvVYVGSSCSLLVIDRGN 158
Cdd:cd14954 233 HRVQVFSPDGEFLCSFGTEGNGEGQFDRPSG----------VAVTPDGRIVVVDRGN 279
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 23-185 2.99e-06

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 48.73  E-value: 2.99e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698018  23 PYSIEVLPNGELLILDSENSNIYKISSSLSLysrprlVT--GSPEGYPGHvdgrlrdakLNHPKGLTVDDRGNIYVADTV 100
Cdd:cd14955 112 PSGIAVDSAGNVYVTDSGNNRIQKFDSSGTF------ITkwGSFGSGDGQ---------FNSPTGIAVDSAGNVYVADTG 176

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698018 101 NNAIRKI-SEGGVTTIAGGktvrngghvdGPSEDAKFSNDFDVVyVGSSCSLLVIDRGNKAIREiqlhFD-DCAYQ---- 174
Cdd:cd14955 177 NNRIQKFtSTGTFLTKWGS----------EGSGDGQFNAPYGIA-VDSAGNVYVADTGNNRIQK----FDsSGTFItkwg 241

                       170
                ....*....|....*..
gi 30698018 175 -YGSG-----FPLGIAV 185
Cdd:cd14955 242 sEGSGdgqfnSPSGIAV 258
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 15-150 3.10e-06

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 48.43  E-value: 3.10e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698018  15 DGSKLGIEPYSIEVLPNGELLILDSENSNIYKisssLSLYSRPRLVTGSPEGYPGHVDGrlrdaklnhPKGLTVDDRGNI 94
Cdd:cd14956  54 DGPGQFGRPRGLAVDKDGWLYVADYWGDRIQV----FTLTGELQTIGGSSGSGPGQFNA---------PRGVAVDADGNL 120

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 30698018  95 YVADTVNNAIRKISEGGVTTIAGGKTVRNGGHVDGPsEDAKFSNDfDVVYVGSSCS 150
Cdd:cd14956 121 YVADFGNQRIQKFDPDGSFLRQWGGTGIEPGSFNYP-RGVAVDPD-GTLYVADTYN 174
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 16-104 3.93e-06

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 48.06  E-value: 3.93e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698018  16 GSKLG--IEPYSIEVLPNGELLILDSEN----------SNIYKISSS---LSLYSRPR-------------------LVT 61
Cdd:cd14963 141 GSEPGelSYPNGIAVDEDGNIYVADSGNgriqvfdkngKFIKELNGSpdgKSGFVNPRgiavdpdgnlyvvdnlshrVYV 220

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 30698018  62 GSPEGYPGHVDGR--LRDAKLNHPKGLTVDDRGNIYVADTVNNAI 104
Cdd:cd14963 221 FDEQGKELFTFGGrgKDDGQFNLPNGLFIDDDGRLYVTDRENNRV 265
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 21-108 9.77e-06

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 47.19  E-value: 9.77e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698018  21 IEPYSIEVLPNGELLILDSENSNIYKISSSLSLysrprlvtGSPEGYPGHVDGrlrdaKLNHPKGLTVDDRGNIYVADTV 100
Cdd:cd14955 204 NAPYGIAVDSAGNVYVADTGNNRIQKFDSSGTF--------ITKWGSEGSGDG-----QFNSPSGIAVDSAGNVYVADSG 270


                ....*...
gi 30698018 101 NNAIRKIS 108
Cdd:cd14955 271 NNRIQKFA 278
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 80-185 2.70e-05

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 45.28  E-value: 2.70e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698018  80 LNHPKGLTVDDRGNIYVADTVNNAIRKISEGgvttiAGGKTVRNGGHVDGPSedakfsndfdVVYVGSSCSLLVIDRGNK 159
Cdd:cd14952 135 LSNPDGVAVDGAGNVYVTDTGNNRVLKLAAG-----STTQTVLPFTGLNSPS----------GVAVDTAGNVYVTDHGNN 199

                        90       100       110
                ....*....|....*....|....*....|....
gi 30698018 160 AIRE--------IQLHFDdcayqyGSGFPLGIAV 185
Cdd:cd14952 200 RVLKlaagsttpTVLPFT------GLNGPLGVAV 227
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 22-148 5.85e-05

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 44.56  E-value: 5.85e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698018  22 EPYSIEVLPNGELLILDSENSNIYKISSSLSLYSRprlVTGSPEGypghvdgrlrDAKLNHPKGLTVDDRGNIYVADTVN 101
Cdd:cd14957 160 GPQGIAVDSDGNIYVADTGNHRIQVFTSSGTFQYT---FGSSGSG----------PGQFSDPYGIAVDSDGNIYVADTGN 226

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 30698018 102 NAIRKISEGGVTTIAGGKTVRNGGHVDGPSEDAKFSNDFdvVYVGSS 148
Cdd:cd14957 227 HRIQVFTSSGAYQYSIGTSGSGNGQFNYPYGIAVDNDGK--IYVADS 271
NHL_TRIM32_like cd14961
NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; ...
 22-186 7.35e-05

NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; The E3 ubiquitin-protein ligase TRIM32 (HT2A) is widely expressed and is responsible for ubiquinating a large variety of targets, including dysbindin (DTNBP1), NPHP7/Glis2, TAp73, and others. TRIM32 promotes disassociation of the plakoglobin-PI3K complex and reduces PI3K-Akt-FoxO signaling. Mutations in TRIM32 have been implemented in the two diverse diseases limb-girdle muscular dystrophy type 2H (LGMD2H) or sarcotubular myopathy (STM) and Bardet-Biedl syndrome type 11 (BBS11). The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271331 [Multi-domain]  Cd Length: 273  Bit Score: 44.19  E-value: 7.35e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698018  22 EPYSIEVLPNGELLILDSENSNIYkissslslysrpRLVTGSPEGYPGHvdGRLRDAKLNHPKGLTVDDRGNIYVADTVN 101
Cdd:cd14961 100 LPWGVAVNPSGEILVTDSEAGKLF------------VLTVDFKLGILKK--GQKLCSQLCRPRFVAVSRLGAVAVTEHLF 165

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698018 102 NAIRKISEGGVTTIAGGKTVRNGGHVDGPSEDAKFSNDFDVVYVGSSCSLLVIDRGNKAIreIQLHFDD---CAYQ---Y 175
Cdd:cd14961 166 ANGTRSSSTRVKVFSSGGQLLGQIDSFGLNLVFPSLICASGVAFDSEGNVIVADTGSGAI--LCLGKPEgfpILKPivtQ 243

                       170
                ....*....|.
gi 30698018 176 GSGFPLGIAVL 186
Cdd:cd14961 244 GLSRPVGLAVT 254
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 22-185 9.95e-05

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 44.10  E-value: 9.95e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698018  22 EPYSIEVLPNGELLILDSENSNIYKISSslslysrprlvTGSPE---GYPGHVDGrlrdaKLNHPKGLTVDDRGNIYVAD 98
Cdd:cd14955  64 SPTGIAVDSDGNVYVADTGNHRIQKFDS-----------TGTFLtkwGSSGSGDG-----QFNSPSGIAVDSAGNVYVTD 127

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698018  99 TVNNAIRKISEGGvTTIAggKTVRNGghvdgpSEDAKFSNDFDVVyVGSSCSLLVIDRGNKAIREiqlhFD-DCAYQ--- 174
Cdd:cd14955 128 SGNNRIQKFDSSG-TFIT--KWGSFG------SGDGQFNSPTGIA-VDSAGNVYVADTGNNRIQK----FTsTGTFLtkw 193

                       170
                ....*....|....*...
gi 30698018 175 --YGSG-----FPLGIAV 185
Cdd:cd14955 194 gsEGSGdgqfnAPYGIAV 211
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 80-185 1.81e-04

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 43.02  E-value: 1.81e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698018  80 LNHPKGLTVDDRGNIYVADTVNNAIRKISEGGVTTIAGGktvrNGGHVDGpsedaKFSNDFDvVYVGSSCSLLVIDRGNK 159
Cdd:cd14957  17 FNTPRGIAVDSAGNIYVADTGNNRIQVFTSSGVYSYSIG----SGGTGSG-----QFNSPYG-IAVDSNGNIYVADTDNN 86

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 30698018 160 airEIQLHFDDCAYQY--GSG--------FPLGIAV 185
Cdd:cd14957  87 ---RIQVFNSSGVYQYsiGTGgsgdgqfnGPYGIAV 119
NHL pfam01436
NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is ...
 80-106 7.11e-04

NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is about 40 residues long and resembles the WD repeat pfam00400. The repeats have a catalytic activity in Swiss:P10731, proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Swiss:Q13049 interacts with the activation domain of Tat. This interaction is me diated by the NHL repeats.


Pssm-ID: 396153 [Multi-domain]  Cd Length: 28  Bit Score: 36.61  E-value: 7.11e-04
                          10        20
                  ....*....|....*....|....*..
gi 30698018    80 LNHPKGLTVDDRGNIYVADTVNNAIRK 106
Cdd:pfam01436   1 FNRPHGVAVDSNGDIYVADSENHRVQV 27
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 76-185 7.46e-04

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 41.38  E-value: 7.46e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698018  76 RDAKLNHPKGLTVDDRGNIYVADTVNNAIRKISEGGVTTIA-GGKTVRNGghvdgpsedaKFSNDFDVVyVGSSCSLLVI 154
Cdd:cd14954  66 RDGQFDRPAGVAVNSRGRIIVADKDNHRIQVFDLNGRFLLKfGERGTKNG----------QFNYPWGVA-VDSEGRIYVS 134

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 30698018 155 DRGNkaiREIQLHFDDCAY--QYGS--------GFPLGIAV 185
Cdd:cd14954 135 DTRN---HRVQVFDSDGQFirKFGFegagpgqlDSPRGVAV 172
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 23-119 8.48e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 41.12  E-value: 8.48e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698018  23 PYSIEVLPNGELLILDSENSNIYKISSS---LSLY--SRPRLVTGSPEG--------YPGHV----------DGRL---- 75
Cdd:cd14963  58 PYGIAVDSDGNIYVADLYNGRIQVFDPDgkfLKYFpeKKDRVKLISPAGlaiddgklYVSDVkkhkvivfdlEGKLllef 137

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 30698018  76 -----RDAKLNHPKGLTVDDRGNIYVADTVNNAIRKISEGG--VTTIAGGK 119
Cdd:cd14963 138 gkpgsEPGELSYPNGIAVDEDGNIYVADSGNGRIQVFDKNGkfIKELNGSP 188
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 80-110 1.22e-03

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 40.27  E-value: 1.22e-03
                        10        20        30
                ....*....|....*....|....*....|.
gi 30698018  80 LNHPKGLTVDDRGNIYVADTVNNAIRKISEG 110
Cdd:cd14952  93 LNDPTGVAVDAAGNVYVADTGNNRVLKLAAG 123
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 80-158 1.37e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 40.34  E-value: 1.37e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 30698018  80 LNHPKGLTVDDRGNIYVADTVNNAIRKISEGGVTTIAGGKTvrngghvdgPSEDAKFSNDFDVVyVGSSCSLLVIDRGN 158
Cdd:cd14956 200 FNYPYGIAIDPDGNVFVADFGNNRIQKFTADGTFLTSWGSP---------GTGPGQFKNPWGVV-VDADGTVYVADSNN 268
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 80-108 2.13e-03

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 39.50  E-value: 2.13e-03
                        10        20
                ....*....|....*....|....*....
gi 30698018  80 LNHPKGLTVDDRGNIYVADTVNNAIRKIS 108
Cdd:cd14952 219 LNGPLGVAVDAAGNVYVADRGNDRVVKLP 247
NHL_TRIM32_like cd14961
NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; ...
 76-185 3.01e-03

NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; The E3 ubiquitin-protein ligase TRIM32 (HT2A) is widely expressed and is responsible for ubiquinating a large variety of targets, including dysbindin (DTNBP1), NPHP7/Glis2, TAp73, and others. TRIM32 promotes disassociation of the plakoglobin-PI3K complex and reduces PI3K-Akt-FoxO signaling. Mutations in TRIM32 have been implemented in the two diverse diseases limb-girdle muscular dystrophy type 2H (LGMD2H) or sarcotubular myopathy (STM) and Bardet-Biedl syndrome type 11 (BBS11). The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271331 [Multi-domain]  Cd Length: 273  Bit Score: 39.18  E-value: 3.01e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698018  76 RDAKLNHPKGLTVDDRGNIYVADTVNNAIRKISEGGvttiaggktvrNGGHVDGPSEDAKFSND--FDVVyVGSSCSLLV 153
Cdd:cd14961   6 WPGTLNNPTGVAVTPTGRVVVADDGNKRIQVFDSDG-----------NCLQQFGPKGDAGQDIRypLDVA-VTPDGHIVV 73

                        90       100       110
                ....*....|....*....|....*....|....*
gi 30698018 154 IDRGNKAIREIQlhFDDCAYQY-GSGF--PLGIAV 185
Cdd:cd14961  74 TDAGDRSVKVFS--FDGRLKLFvRKSFslPWGVAV 106
PLN02919 PLN02919
haloacid dehalogenase-like hydrolase family protein
 32-166 4.14e-03

haloacid dehalogenase-like hydrolase family protein


Pssm-ID: 215497 [Multi-domain]  Cd Length: 1057  Bit Score: 39.83  E-value: 4.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698018    32 GELLILDSEnsniyKISSSLSLYSRPRLVTgSPEGYPGH-----VDGRLRDAKLNHPKgltvddrgnIYVADTVNNAIRK 106
Cdd:PLN02919  540 GEKKLLDST-----PLPLSLEKDNDPRLLT-SPLKFPGKlaidlLNNRLFISDSNHNR---------IVVTDLDGNFIVQ 604

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698018   107 ISEGGvttiaggktvrNGGHVDGPSEDAKFSNDFDVVYVGSSCSLLVIDRGNKAIREIQL 166
Cdd:PLN02919  605 IGSTG-----------EEGLRDGSFEDATFNRPQGLAYNAKKNLLYVADTENHALREIDF 653
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 31-111 4.52e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 38.81  E-value: 4.52e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698018  31 NGELLILDSENSNIYKISSSlslySRPRLVTGSPEGYPGhvdgrlrdaKLNHPKGLTVDDRGNIYVADTVNNAIRKISEG 110
Cdd:cd14963  19 DGRIYVADTNNHRVQVFDYE----GKFKKSFGGPGTGPG---------EFKYPYGIAVDSDGNIYVADLYNGRIQVFDPD 85


                .
gi 30698018 111 G 111
Cdd:cd14963  86 G 86
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 80-129 6.01e-03

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 38.34  E-value: 6.01e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 30698018  80 LNHPKGLTVDDRGNIYVADTVNNAIRKISEG--GVTTI-AGGKTVRNGGHVDG 129
Cdd:cd14952   9 LDGPGGVAVDAAGNVYVADSGNNRVLKLAAGstTQTVLpFTGLYQPQGVAVDA 61
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 1-161 6.14e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 38.42  E-value: 6.14e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698018   1 MVKFENGYSVETVF--DGSKLG--IEPYSIEVLPNGELLILDSENSNIYKISSS---LSLYsrprlvtGSPEGYPGHvdg 73
Cdd:cd14956  83 IQVFTLTGELQTIGgsSGSGPGqfNAPRGVAVDADGNLYVADFGNQRIQKFDPDgsfLRQW-------GGTGIEPGS--- 152

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698018  74 rlrdakLNHPKGLTVDDRGNIYVADTVNNAIRkiseggVTTIAGGKTVRNGGHVDGPSEdakFSNDFDVVyVGSSCSLLV 153
Cdd:cd14956 153 ------FNYPRGVAVDPDGTLYVADTYNDRIQ------VFDNDGAFLRKWGGRGTGPGQ---FNYPYGIA-IDPDGNVFV 216


                ....*...
gi 30698018 154 IDRGNKAI 161
Cdd:cd14956 217 ADFGNNRI 224
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
58-166 6.19e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 38.14  E-value: 6.19e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698018  58 RLVTGSPEGYPGHVDGRLRDAKLNHPKGLTVDDRGNIYVADTVNNAIRKISeggvttIAGGKTVRNGGHVDGPSEDAkFS 137
Cdd:COG3391  46 GAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGSGRVSVID------LATGKVVATIPVGGGPRGLA-VD 118

                        90       100       110
                ....*....|....*....|....*....|..
gi 30698018 138 NDFDVVYVGSSCS--LLVID-RGNKAIREIQL 166
Cdd:COG3391 119 PDGGRLYVADSGNgrVSVIDtATGKVVATIPV 150
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 76-185 6.61e-03

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 38.30  E-value: 6.61e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698018  76 RDAKLNHPKGLTVDDRGNIYVADTVNNAIRKISEGGvTTIAGGKTVRNG-GHVDGPSEDAkFSNDfDVVYVGSSCS--LL 152
Cdd:cd14954 113 KNGQFNYPWGVAVDSEGRIYVSDTRNHRVQVFDSDG-QFIRKFGFEGAGpGQLDSPRGVA-VNPD-GNIVVSDFNNhrLQ 189

                        90       100       110
                ....*....|....*....|....*....|....
gi 30698018 153 VIDRGNKAIREiqlhFDDCAYQYGS-GFPLGIAV 185
Cdd:cd14954 190 VFDPDGQFLRF----FGSEGSGNGQfKRPRGVAV 219
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 21-111 9.85e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 37.57  E-value: 9.85e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698018  21 IEPYSIEVLPNGELLILDSENSNIY----------KISSSLsLYSRPRLVTGSPEG---Y---PGH-------VDGRLR- 76
Cdd:cd14962  57 VSPIGVAIDANGNLYVSDAELGKVFvfdrdgkflrAIGAGA-LFKRPTGIAVDPAGkrlYvvdTLAhkvkvfdLDGRLLf 135

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 30698018  77 --------DAKLNHPKGLTVDDRGNIYVADTVNNAIRKISEGG 111
Cdd:cd14962 136 digkrgsgPGEFNLPTDLAVDRDGNLYVTDTMNFRVQIFDADG 178
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 80-102 9.94e-03

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 37.57  E-value: 9.94e-03
                        10        20
                ....*....|....*....|...
gi 30698018  80 LNHPKGLTVDDRGNIYVADTVNN 102
Cdd:cd14952  51 LYQPQGVAVDAAGTVYVTDFGNN 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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