NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|30679836|ref|NP_849603|]
View 

alpha/beta-Hydrolases superfamily protein [Arabidopsis thaliana]

Protein Classification

alpha/beta hydrolase family protein( domain architecture ID 229394)

alpha/beta hydrolase family protein may catalyze the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Abhydrolase super family cl21494
alpha/beta hydrolases; A functionally diverse superfamily containing proteases, lipases, ...
 1-515 0e+00

alpha/beta hydrolases; A functionally diverse superfamily containing proteases, lipases, peroxidases, esterases, epoxide hydrolases and dehalogenases. The catalytic apparatus typically involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine, and often the mechanism involves a nucleophilic attack on a carbonyl carbon atom.


The actual alignment was detected with superfamily member PLN02719:

Pssm-ID: 473884  Cd Length: 518  Bit Score: 1050.45  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836    1 MATIPSHNLR---PHTTNQRTQYSLSFRPHFSRSTLITFPARSSPARAMSRTDEEASISTRLEQESYGLTTAEDIRRRDG 77
Cdd:PLN02719   1 MATIPSHNFHlrlPHMINQRTQYSLSFKPHFSHSTLITFPARASPARAMSRTDEEASISTRLEPESYGLTTAEDIRRRDG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836   78 EAKESKRLRDTWRKIQGEDDWAGLMDPMDPVLRSELIRYGEMAQACYDAFDFDPFSRYCGSCRFTRRHLFDSLGIIDSGY 157
Cdd:PLN02719  81 EAKESKRLRDTWRKIQGEDDWAGLMDPMDPVLRSELIRYGEMAQACYDAFDFDPFSRYCGSCRFTRRHLFDSLGIIDSGY 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836  158 EVARYLYATSNINLPNFFSKSRWSKVWSKNANWMGYVAVSDDNEATRCRLGRRDIAIAWRGTVTRLEWIADLKDFLKPVS 237
Cdd:PLN02719 161 EVARYLYATSNINLPNFFSKSRWSKVWSKNANWIGYVAVSDDDEATRCRLGRRDIAIAWRGTVTRLEWIADLKDFLKPVS 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836  238 GNGFRCPDPAVKAESGFLDLYTDKDTSCNFSKFSAREQVLTEVKRLVERYGDEEGEELSITVTGHSLGGALAVLSAYDVA 317
Cdd:PLN02719 241 GNGFRCPDPAVKAESGFLDLYTDKDTCCNFSKFSAREQVLTEVKRLVERYGDEEGEELSITVTGHSLGGALAVLSAYDVA 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836  318 EMGVNRTRKGKVIPVTAFTYGGPRVGNIRFKERIEKLGVKVLRVVNEHDVVAKSPGLFLNERAPQALMKLAGGLPWCYSH 397
Cdd:PLN02719 321 EMGLNRTRKGKVIPVTAFTYGGPRVGNIRFKERIEELGVKVLRVVNEHDVVAKSPGLFLNERAPQALMKLAGGLPWCYSH 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836  398 VGEMLPLDHQKSPFLKPTVDLSTAHNLEALLHLLDGYHGKGQRFVLSSGRDPALVNKASDFLKDHFMVPPYWRQDANKGM 477
Cdd:PLN02719 401 VGEMLPLDHQKSPFLKPTVDLSTAHNLEALLHLLDGYHGKGQRFVLSSGRDPALVNKASDFLKDHFMVPPYWRQDANKGM 480

                        490       500       510
                 ....*....|....*....|....*....|....*...
gi 30679836  478 VRNTDGRWIQPDRIRADDQHAPDIHQLLTQLHHPSQLL 515
Cdd:PLN02719 481 VRNTDGRWIQPDRIRADDHHAPDIHQLLTQLHHPSQLL 518
 
Name Accession Description Interval E-value
PLN02719 PLN02719
triacylglycerol lipase
 1-515 0e+00

triacylglycerol lipase


Pssm-ID: 178321  Cd Length: 518  Bit Score: 1050.45  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836    1 MATIPSHNLR---PHTTNQRTQYSLSFRPHFSRSTLITFPARSSPARAMSRTDEEASISTRLEQESYGLTTAEDIRRRDG 77
Cdd:PLN02719   1 MATIPSHNFHlrlPHMINQRTQYSLSFKPHFSHSTLITFPARASPARAMSRTDEEASISTRLEPESYGLTTAEDIRRRDG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836   78 EAKESKRLRDTWRKIQGEDDWAGLMDPMDPVLRSELIRYGEMAQACYDAFDFDPFSRYCGSCRFTRRHLFDSLGIIDSGY 157
Cdd:PLN02719  81 EAKESKRLRDTWRKIQGEDDWAGLMDPMDPVLRSELIRYGEMAQACYDAFDFDPFSRYCGSCRFTRRHLFDSLGIIDSGY 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836  158 EVARYLYATSNINLPNFFSKSRWSKVWSKNANWMGYVAVSDDNEATRCRLGRRDIAIAWRGTVTRLEWIADLKDFLKPVS 237
Cdd:PLN02719 161 EVARYLYATSNINLPNFFSKSRWSKVWSKNANWIGYVAVSDDDEATRCRLGRRDIAIAWRGTVTRLEWIADLKDFLKPVS 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836  238 GNGFRCPDPAVKAESGFLDLYTDKDTSCNFSKFSAREQVLTEVKRLVERYGDEEGEELSITVTGHSLGGALAVLSAYDVA 317
Cdd:PLN02719 241 GNGFRCPDPAVKAESGFLDLYTDKDTCCNFSKFSAREQVLTEVKRLVERYGDEEGEELSITVTGHSLGGALAVLSAYDVA 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836  318 EMGVNRTRKGKVIPVTAFTYGGPRVGNIRFKERIEKLGVKVLRVVNEHDVVAKSPGLFLNERAPQALMKLAGGLPWCYSH 397
Cdd:PLN02719 321 EMGLNRTRKGKVIPVTAFTYGGPRVGNIRFKERIEELGVKVLRVVNEHDVVAKSPGLFLNERAPQALMKLAGGLPWCYSH 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836  398 VGEMLPLDHQKSPFLKPTVDLSTAHNLEALLHLLDGYHGKGQRFVLSSGRDPALVNKASDFLKDHFMVPPYWRQDANKGM 477
Cdd:PLN02719 401 VGEMLPLDHQKSPFLKPTVDLSTAHNLEALLHLLDGYHGKGQRFVLSSGRDPALVNKASDFLKDHFMVPPYWRQDANKGM 480

                        490       500       510
                 ....*....|....*....|....*....|....*...
gi 30679836  478 VRNTDGRWIQPDRIRADDQHAPDIHQLLTQLHHPSQLL 515
Cdd:PLN02719 481 VRNTDGRWIQPDRIRADDHHAPDIHQLLTQLHHPSQLL 518
Lipase_3 cd00519
Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into ...
 143-406 1.53e-49

Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the process of becoming active at the lipid/water interface, although several examples of lipases have been identified that do not undergo interfacial activation . The active site of a lipase contains a catalytic triad consisting of Ser - His - Asp/Glu, but unlike most serine proteases, the active site is buried inside the structure. A "lid" or "flap" covers the active site, making it inaccessible to solvent and substrates. The lid opens during the process of interfacial activation, allowing the lipid substrate access to the active site.


Pssm-ID: 238287 [Multi-domain]  Cd Length: 229  Bit Score: 169.96  E-value: 1.53e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836 143 RRHLFDSLGIIDSGYEVARYLYAT----SNINLPNFFSKSRWSKvWSKNANWMGYVAVSDDneatrcrlgRRDIAIAWRG 218
Cdd:cd00519   2 YEKLKYYAKLAAAAYCVDANILAKavvfADIALLNVFSPDKLLK-TDKQYDTQGYVAVDHD---------RKTIVIAFRG 71

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836 219 TVTRLEWIADLKDFLKPVSgngfRCPDPAVKAESGFLDLYTdkdtscnfskfSAREQVLTEVKRLVERYGDeegeeLSIT 298
Cdd:cd00519  72 TVSLADWLTDLDFSPVPLD----PPLCSGGKVHSGFYSAYK-----------SLYNQVLPELKSALKQYPD-----YKII 131

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836 299 VTGHSLGGALAVLSAYDVAEMGVNRtrkgkviPVTAFTYGGPRVGNIRFKERIEKLGVKVLRVVNEHDVVAKSPGLFLNe 378
Cdd:cd00519 132 VTGHSLGGALASLLALDLRLRGPGS-------DVTVYTFGQPRVGNAAFAEYLESTKGRVYRVVHGNDIVPRLPPGSLT- 203

                       250       260
                ....*....|....*....|....*...
gi 30679836 379 rapqalmklaggLPWCYSHVGEMLPLDH 406
Cdd:cd00519 204 ------------PPEGYTHVGTEVWIDH 219
Lipase_3 pfam01764
Lipase (class 3);
214-375 1.46e-47

Lipase (class 3);


Pssm-ID: 396362 [Multi-domain]  Cd Length: 139  Bit Score: 161.27  E-value: 1.46e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836   214 IAWRGTVTRLEWIADLKDFLKPVSGngfrCPDPAVKAESGFLDLYTdkdtscnfskfSAREQVLTEVKRLVERYGDeege 293
Cdd:pfam01764   2 VAFRGTNSILDWLTDFDFSLTPFKD----FFLGGGKVHSGFLSAYT-----------SVREQVLAELKRLLEKYPD---- 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836   294 eLSITVTGHSLGGALAVLSAYDVAEMGVNRtrkgkVIPVTAFTYGGPRVGNIRFKERIEKLGVK-VLRVVNEHDVVAKSP 372
Cdd:pfam01764  63 -YSIVVTGHSLGGALASLAALDLVENGLRL-----SSRVTVVTFGQPRVGNLEFAKLHDSQGPKfSYRVVHQRDIVPRLP 136


                  ...
gi 30679836   373 GLF 375
Cdd:pfam01764 137 PIV 139
Lip2 COG3675
Predicted lipase [Lipid transport and metabolism];
208-409 5.66e-22

Predicted lipase [Lipid transport and metabolism];


Pssm-ID: 442891 [Multi-domain]  Cd Length: 266  Bit Score: 95.59  E-value: 5.66e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836 208 GRRDIAIAWRGTVTRLEWIADLKDFLKPVSGNGfrcpdPAVKAESGFLDLYTdkdtscnfskfSAREQVLTEVKRLvery 287
Cdd:COG3675  25 SDDEVIVAFRGTESLTDWLTNLNAAQVPYPFAK-----TGGKVHRGFYRALQ-----------SLRELLEDALRPL---- 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836 288 gdeeGEELSITVTGHSLGGALAVLSAYDVAEMGVNrtrkgKVIPVtaFTYGGPRVGNIRFKERIEKLGVKVLRVVNEHDV 367
Cdd:COG3675  85 ----SPGKRLYVTGHSLGGALATLAAADLERNYIF-----PVRGL--YTFGQPRVGDRSFAKYYNLHVPNSYRIVNNNDI 153

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 30679836 368 VAKSPglflneraPQalmklagglPWCYSHVGEMLPLDHQKS 409
Cdd:COG3675 154 VPLLP--------PV---------WMGYDHVGKLLWLDSLRK 178
 
Name Accession Description Interval E-value
PLN02719 PLN02719
triacylglycerol lipase
 1-515 0e+00

triacylglycerol lipase


Pssm-ID: 178321  Cd Length: 518  Bit Score: 1050.45  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836    1 MATIPSHNLR---PHTTNQRTQYSLSFRPHFSRSTLITFPARSSPARAMSRTDEEASISTRLEQESYGLTTAEDIRRRDG 77
Cdd:PLN02719   1 MATIPSHNFHlrlPHMINQRTQYSLSFKPHFSHSTLITFPARASPARAMSRTDEEASISTRLEPESYGLTTAEDIRRRDG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836   78 EAKESKRLRDTWRKIQGEDDWAGLMDPMDPVLRSELIRYGEMAQACYDAFDFDPFSRYCGSCRFTRRHLFDSLGIIDSGY 157
Cdd:PLN02719  81 EAKESKRLRDTWRKIQGEDDWAGLMDPMDPVLRSELIRYGEMAQACYDAFDFDPFSRYCGSCRFTRRHLFDSLGIIDSGY 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836  158 EVARYLYATSNINLPNFFSKSRWSKVWSKNANWMGYVAVSDDNEATRCRLGRRDIAIAWRGTVTRLEWIADLKDFLKPVS 237
Cdd:PLN02719 161 EVARYLYATSNINLPNFFSKSRWSKVWSKNANWIGYVAVSDDDEATRCRLGRRDIAIAWRGTVTRLEWIADLKDFLKPVS 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836  238 GNGFRCPDPAVKAESGFLDLYTDKDTSCNFSKFSAREQVLTEVKRLVERYGDEEGEELSITVTGHSLGGALAVLSAYDVA 317
Cdd:PLN02719 241 GNGFRCPDPAVKAESGFLDLYTDKDTCCNFSKFSAREQVLTEVKRLVERYGDEEGEELSITVTGHSLGGALAVLSAYDVA 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836  318 EMGVNRTRKGKVIPVTAFTYGGPRVGNIRFKERIEKLGVKVLRVVNEHDVVAKSPGLFLNERAPQALMKLAGGLPWCYSH 397
Cdd:PLN02719 321 EMGLNRTRKGKVIPVTAFTYGGPRVGNIRFKERIEELGVKVLRVVNEHDVVAKSPGLFLNERAPQALMKLAGGLPWCYSH 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836  398 VGEMLPLDHQKSPFLKPTVDLSTAHNLEALLHLLDGYHGKGQRFVLSSGRDPALVNKASDFLKDHFMVPPYWRQDANKGM 477
Cdd:PLN02719 401 VGEMLPLDHQKSPFLKPTVDLSTAHNLEALLHLLDGYHGKGQRFVLSSGRDPALVNKASDFLKDHFMVPPYWRQDANKGM 480

                        490       500       510
                 ....*....|....*....|....*....|....*...
gi 30679836  478 VRNTDGRWIQPDRIRADDQHAPDIHQLLTQLHHPSQLL 515
Cdd:PLN02719 481 VRNTDGRWIQPDRIRADDHHAPDIHQLLTQLHHPSQLL 518
PLN02753 PLN02753
triacylglycerol lipase
 1-511 0e+00

triacylglycerol lipase


Pssm-ID: 178354  Cd Length: 531  Bit Score: 808.17  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836    1 MATIPSHN---LRPHTTNQRTQYSLSFRPHFSRstlITFPARSSPA-RAMSRTDEEA--SISTRLEQE-----------S 63
Cdd:PLN02753   1 MAAIPSHNnllTINHKNSITGHHSSSLNTKFSE---INFPAKFQVAtRALSRTDESSlsAVISRLERErrerqgllideA 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836   64 YGL----TTAEDIRRRDGEAKESKRLRDTWRKIQGEDDWAGLMDPMDPVLRSELIRYGEMAQACYDAFDFDPFSRYCGSC 139
Cdd:PLN02753  78 EGAgelwLTAEDIRRRDKKTEEERRLRDTWRKIQGEDDWAGLIDPMDPILRSELIRYGEMAQACYDAFDFDPASKYCGTS 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836  140 RFTRRHLFDSLGIIDSGYEVARYLYATSNINLPNFFSKSRWSKVWSKNANWMGYVAVSDDnEATRCRLGRRDIAIAWRGT 219
Cdd:PLN02753 158 RFSRLDFFDSLGMIDSGYEVARYLYATSNINLPNFFSKSRWSKVWSKNANWMGYVAVSDD-ETSRNRLGRRDIAIAWRGT 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836  220 VTRLEWIADLKDFLKPVSGNGFRCPDPAVKAESGFLDLYTDKDTSCNFSKFSAREQVLTEVKRLVERYGDEEGEELSITV 299
Cdd:PLN02753 237 VTKLEWIADLKDYLKPVSENKIRCPDPAVKVESGFLDLYTDKDTTCKFAKFSAREQILTEVKRLVEEHGDDDDSDLSITV 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836  300 TGHSLGGALAVLSAYDVAEMGVNRTRKGKVIPVTAFTYGGPRVGNIRFKERIEKLGVKVLRVVNEHDVVAKSPGLFLNER 379
Cdd:PLN02753 317 TGHSLGGALAILSAYDIAEMGLNRSKKGKVIPVTVLTYGGPRVGNVRFKDRMEELGVKVLRVVNVHDVVPKSPGLFLNES 396

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836  380 APQALMKLAGGLPWCYSHVGEMLPLDHQKSPFLKPTVDLSTAHNLEALLHLLDGYHGKGQRFVLSSGRDPALVNKASDFL 459
Cdd:PLN02753 397 RPHALMKIAEGLPWCYSHVGEELALDHQNSPFLKPSVDLSTAHNLEAMLHLLDGYHGKGERFVLSSGRDHALVNKASDFL 476

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....
gi 30679836  460 KDHFMVPPYWRQDANKGMVRNTDGRWIQPDRIRADDQHAPDIHQLLTQLH--HP 511
Cdd:PLN02753 477 KEHLQIPPFWRQDANKGMVRNSEGRWIQAERLRFEDHHSPDIHHHLSQLRldHP 530
PLN02761 PLN02761
lipase class 3 family protein
 11-515 0e+00

lipase class 3 family protein


Pssm-ID: 215406 [Multi-domain]  Cd Length: 527  Bit Score: 615.52  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836   11 PHTTNQRTQYSLSFRPHFSR--STLITFPARSSPARAMSRTDEEASISTRLEQESYGLTTAEDIRRRDGEAKESKR---- 84
Cdd:PLN02761   7 PITLKNPRFFSSSPNKIFKTqpQTLILTTKFKTCSIICSSSCTSISSSTTQQKQSNKQTHVSDNKREEEPEEELEEkevs 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836   85 LRDTWRKIQGEDDWAGLMDPMDPVLRSELIRYGEMAQACYDAFDFDPFSRYCGSCRFTRRHLFDSLGI-IDSGYEVARYL 163
Cdd:PLN02761  87 LREIWREVQGCNNWEGLLDPMNNHLRREIIRYGEFAQACYDSFDFDPHSKYCGSCKYHPSDFFQNLDLhLHKGYTITRYL 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836  164 YATSNINLPNFFSKSRWSKVWSKNANWMGYVAVSDDNEATRcRLGRRDIAIAWRGTVTRLEWIADLKDFLKPVSgngFRc 243
Cdd:PLN02761 167 YATSNINLPNFFQKSKLSSIWSQHANWMGYVAVATDEEEVK-RLGRRDIVIAWRGTVTYLEWIYDLKDILCSAN---FG- 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836  244 PDPAVKAESGFLDLYTDKDTSCNFSKFSAREQVLTEVKRLVERYG-DEEGEELSITVTGHSLGGALAVLSAYDVAEMGVN 322
Cdd:PLN02761 242 DDPSIKIELGFHDLYTKKEDSCKFSSFSAREQVLAEVKRLVEYYGtEEEGHEISITVTGHSLGASLALVSAYDIAELNLN 321

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836  323 RTRKGKV-IPVTAFTYGGPRVGNIRFKERIEKLGVKVLRVVNEHDVVAKSPGLFLNERAP-QALMKLAGGLPWCYSHVGE 400
Cdd:PLN02761 322 HVPENNYkIPITVFSFSGPRVGNLRFKERCDELGVKVLRVVNVHDKVPSVPGIFTNEKFQfQKYVEEKTSFPWSYAHVGV 401

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836  401 MLPLDHQKSPFLKPTVDLSTAHNLEALLHLLDGYHGK----GQRFVLSSGRDPALVNKASDFLKDHFMVPPYWRQDANKG 476
Cdd:PLN02761 402 ELALDHKKSPFLKPTKDLGCAHNLEALLHLVDGYHGKdeeaEKRFCLVTKRDIALVNKSCDFLRSEYHVPPCWRQDENKG 481

                        490       500       510
                 ....*....|....*....|....*....|....*....
gi 30679836  477 MVRNTDGRWIQPDRIRADDQHAPDIhqlltqLHHPSQLL 515
Cdd:PLN02761 482 MVKASDGRWVLPDRPRLEPHGPEDI------AHHLQQVL 514
PLN03037 PLN03037
lipase class 3 family protein; Provisional
 89-494 1.26e-149

lipase class 3 family protein; Provisional


Pssm-ID: 215547  Cd Length: 525  Bit Score: 438.62  E-value: 1.26e-149
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836   89 WRKIQGEDDWAGLMDPMDPVLRSELIRYGEMAQACYDAFDFDPFSRYCGSCRFTRRHLFDSLGIIDSGYEVARYLYATSN 168
Cdd:PLN03037 116 WREIHGSNNWENLLDPLHPWLRREVVKYGEFVEATYDAFDFDPLSEFCGSCRYNRHKLFEELGLTKHGYKVTKYIYAMSH 195

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836  169 INLPNFFSKSRWSKVWSKNANWMGYVAVSDDNEATrcRLGRRDIAIAWRGTVTRLEWIADLKDFLKPVSGNGfRCPDPAV 248
Cdd:PLN03037 196 VDVPQWFLRSATGETWSKDSNWMGFVAVSGDRESQ--RIGRRDIVVAWRGTVAPTEWFMDLRTSLEPFDCDG-DHGKNVV 272

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836  249 KAESGFLDLYTDKDTSCNFSKFSAREQVLTEVKRLVERYgDEEGEELSITVTGHSLGGALAVLSAYDVAemgvnrTRKGK 328
Cdd:PLN03037 273 KVQSGFLSIYKSKSELTRYNKLSASEQVMEEVKRLVNFF-KDRGEEVSLTITGHSLGGALALLNAYEAA------RSVPA 345

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836  329 VIPVTAFTYGGPRVGNIRFKERIEKLGVKVLRVVNEHDVVAKSPGLFLNERAPQaLMKLAGGLPWCYSHVGEMLPLDHQK 408
Cdd:PLN03037 346 LSNISVISFGAPRVGNLAFKEKLNELGVKVLRVVNKQDIVPKLPGIIFNKILNK-LNPITSRLNWVYRHVGTQLKLDMFS 424

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836  409 SPFLKPTVDLSTAHNLEALLHLLDGYHGKGQRFVLSSGRDPALVNKASDFLKDHFMVPPYWRQDANKGMVRNTDGRWIQP 488
Cdd:PLN03037 425 SPYLKRESDLGGAHNLEVYLHLLDGFHGKKLGFRWNARRDLALVNKSTDMLIEELRIPEFWYQVPHKGLVLNKQGRWVKP 504


                 ....*.
gi 30679836  489 DRIRAD 494
Cdd:PLN03037 505 VRAPED 510
PLN02310 PLN02310
triacylglycerol lipase
 83-495 6.62e-148

triacylglycerol lipase


Pssm-ID: 215176  Cd Length: 405  Bit Score: 429.79  E-value: 6.62e-148
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836   83 KRLRDTWRKIQGEDDWAGLMDPMDPVLRSELIRYGEMAQACYDAFDFDPFSRYCGSCRFTRRHLFDSLGIIDSGYEVARY 162
Cdd:PLN02310   9 ENMSNKWHEIHGSSNWEHLLDPLHPWLRREILKYGEFAQATYDAFDFDPLSEYCGSCRYNRHKLFETLGLTKHGYKVKKY 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836  163 LYATSNINLPNFFSKSRwsKVWSKNANWMGYVAVSDDNEATRcrLGRRDIAIAWRGTVTRLEWIADLKDFLKPVsGNGfr 242
Cdd:PLN02310  89 IYALSHVDVPHWLKRSQ--ATWSKDSNWMGYVAVSRDEESQR--IGRRDIMVAWRGTVAPSEWFLDLETKLEHI-DNT-- 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836  243 cpdpAVKAESGFLDLYTDKDTSCNFSKFSAREQVLTEVKRLVERYGdEEGEELSITVTGHSLGGALAVLSAYDVAEMGVN 322
Cdd:PLN02310 162 ----NVKVQEGFLKIYKSKDESTRYNKLSASEQVMQEVKRLVNFYR-GKGEEVSLTVTGHSLGGALALLNAYEAATTIPD 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836  323 rtrkgkvIPVTAFTYGGPRVGNIRFKERIEKLGVKVLRVVNEHDVVAKSPGLFlnERAPQALMKLAGGLPWCYSHVGEML 402
Cdd:PLN02310 237 -------LFVSVISFGAPRVGNIAFKEKLNELGVKTLRVVVKQDKVPKLPGLL--NKMLNKFHGLTGKLNWVYRHVGTQL 307

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836  403 PLDHQKSPFLKPTVDLSTAHNLEALLHLLDGYHGKGQRFVLSSGRDPALVNKASDFLKDHFMVPPYWRQDANKGMVRNTD 482
Cdd:PLN02310 308 KLDAFSSPYLKRESDLSGCHNLELYLHLIDGFHSEDSKFRWNARRDLALVNKGSDMLIEDLGIPEFWYQFPYKGLMLNTY 387

                        410
                 ....*....|...
gi 30679836  483 GRWIQPDRIRADD 495
Cdd:PLN02310 388 GRWVKPGRVDQED 400
PLN02454 PLN02454
triacylglycerol lipase
 88-486 1.60e-116

triacylglycerol lipase


Pssm-ID: 215249  Cd Length: 414  Bit Score: 349.91  E-value: 1.60e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836   88 TWRKIQGEDDWAGLMDPMDPVLRSELIRYGEMAQACYDAFDFDPFSRYCGSCRFTRRHLFDSLGIIDSG-YEVARYLYAT 166
Cdd:PLN02454   8 SWPELLGSANWDGLLDPLDLSLRELILRCGDFCQATYDSFNNDQNSKYCGASRYGKSSFFDKVMLEAASdYEVAAFLYAT 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836  167 SNINLPNFF---SKSRWSkvWSKNANWMGYVAVSDDnEATRCrLGRRDIAIAWRGTVTRLEWI----ADL---KDFLKPV 236
Cdd:PLN02454  88 ARVSLPEAFllhSMSRES--WDRESNWIGYIAVTSD-ERTKA-LGRREIYVAWRGTTRNYEWVdvlgAKLtsaDPLLPGP 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836  237 SGNG------FRCPDP---AVKAESGFLDLYTDKDTSCNFSKFSAREQVLTEVKRLVERYGDEEgeeLSITVTGHSLGGA 307
Cdd:PLN02454 164 EQDGvvsgssSDSDDDdekGPKVMLGWLTIYTSDDPRSPFTKLSARSQLLAKIKELLERYKDEK---LSIVLTGHSLGAS 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836  308 LAVLSAYDVAEMGVNrtrkGKVIPVTAFTYGGPRVGNIRFKERIEKL-GVKVLRVVNEHDVVAKSPGLFLNerapqalmk 386
Cdd:PLN02454 241 LATLAAFDIVENGVS----GADIPVTAIVFGSPQVGNKEFNDRFKEHpNLKILHVRNTIDLIPHYPGGLLG--------- 307

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836  387 lagglpwcYSHVGEMLPLDHQKSPFLKPTVDLSTAHNLEALLHLLDGYHGKGQRFVLSSGRDPALVNKASDFLKDHFMVP 466
Cdd:PLN02454 308 --------YVNTGTELVIDTRKSPFLKDSKNPGDWHNLQAMLHVVAGWNGKKGEFELKVKRSLALVNKSCAFLKDECLVP 379

                        410       420
                 ....*....|....*....|
gi 30679836  467 PYWRQDANKGMVRNTDGRWI 486
Cdd:PLN02454 380 GSWWVEKNKGMVRGEDGEWV 399
PLN02571 PLN02571
triacylglycerol lipase
 89-485 4.16e-113

triacylglycerol lipase


Pssm-ID: 215309  Cd Length: 413  Bit Score: 341.10  E-value: 4.16e-113
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836   89 WRKIQGEDDWAGLMDPMDPVLRSELIRYGEMAQACYDAFDFDPFSRYCGSCRFTRRHLFDSLGIiDSG----YEVARYLY 164
Cdd:PLN02571  22 WRHLSGQNHWKGLLDPLDQDLREYIIHYGEMAQATYDTFNIQKASKFAGSSLYAKKDFFAKVGL-EKGnpykYKVTKFLY 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836  165 ATSNINLPN-FFSKSRWSKVWSKNANWMGYVAVSDDNEATRcrLGRRDIAIAWRGTVTRLEWIADLKDFLKPVSgNGFRC 243
Cdd:PLN02571 101 ATSQIHVPEaFILKSLSREAWSKESNWMGYVAVATDEGKAL--LGRRDIVIAWRGTVQTLEWVNDFEFNLVSAS-KIFGE 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836  244 PDPAVKAESGFLDLYTDKDTSCNFSKFSAREQVLTEVKRLVERYGDEEgeeLSITVTGHSLGGALAVLSAYDVAEMGVNR 323
Cdd:PLN02571 178 SNDQPKVHQGWYSIYTSDDERSPFNKTSARDQVLNEVGRLVEKYKDEE---ISITICGHSLGAALATLNAVDIVANGFNR 254

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836  324 --TRKGKVIPVTAFTYGGPRVGNIRFKERIEKL-GVKVLRVVNEHDVVAKSPglflnerapqalmklagglPWCYSHVGE 400
Cdd:PLN02571 255 skSRPNKSCPVTAFVFASPRVGDSDFKKLFSGLkDLRVLRVRNLPDVIPNYP-------------------LIGYSDVGE 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836  401 MLPLDHQKSPFLKPTVDLSTAHNLEALLHLLDGYHGKGQRFVLSSGRDPALVNKASDFLKDHFMVPPYWRQDANKGMVRN 480
Cdd:PLN02571 316 ELPIDTRKSKYLKSPGNLSTWHNLEAYLHGVAGTQGSKGGFRLEVNRDIALVNKSVDGLKDEYLVPGSWRVQKNKGMVQQ 395


                 ....*
gi 30679836  481 TDGRW 485
Cdd:PLN02571 396 ADGSW 400
PLN02324 PLN02324
triacylglycerol lipase
 89-500 1.73e-104

triacylglycerol lipase


Pssm-ID: 177958  Cd Length: 415  Bit Score: 318.88  E-value: 1.73e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836   89 WRKIQGEDDWAGLMDPMDPVLRSELIRYGEMAQACYDAFDFDPFSRYCGSCRFTRRHLFDSLGIIDSG---YEVARYLYA 165
Cdd:PLN02324   9 WKVLSGQNKWKGLLDPLDPDLRRYIIHYGEMSQVGYDAFNWDRKSKYAGDCYYSKNELFARTGFLKANpfrYEVTKYIYA 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836  166 TSNINLP-NFFSKSRWSKVWSKNANWMGYVAVSDDNeaTRCRLGRRDIAIAWRGTVTRLEWIADLkDFLKPVSGNGFRCP 244
Cdd:PLN02324  89 TASIKLPiCFIVKSLSKDASRVQTNWMGYIAVATDQ--GKAMLGRRDIVVAWRGTLQPYEWANDF-DFPLESAISVFPVT 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836  245 DPA--VKAESGFLDLYTDKDTSCNFSKFSAREQVLTEVKRLVERYGDEEgeeLSITVTGHSLGGALAVLSAYDVA---EM 319
Cdd:PLN02324 166 DPKdnPRIGSGWLDIYTASDSRSPYDTTSAQEQVQGELKRLLELYKNEE---ISITFTGHSLGAVMSVLSAADLVygkKN 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836  320 GVNRTRKGKVIPVTAFTYGGPRVGNIRFKERIEKLG-VKVLRVVNEHDVVAKSPgLFLnerapqalmklagglpwcYSHV 398
Cdd:PLN02324 243 KINISLQKKQVPITVFAFGSPRIGDHNFKNLVDSLQpLNILRIVNVPDVAPHYP-LLL------------------YTEI 303

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836  399 GEMLPLDHQKSPFLKPTVDLSTAHNLEALLHLLDGYHGKGQRFVLSSGRDPALVNKASDFLKDHFMVPPYWRQDANKGMV 478
Cdd:PLN02324 304 GEVLEINTLNSTYLKRSLNFRNYHNLEAYLHGVAGMQDTQGEFKLEINRDIALVNKGLDALEDKYLVPGHWWVLENKGMV 383

                        410       420
                 ....*....|....*....|...
gi 30679836  479 RNTDGRW-IQPDRIRADDQHAPD 500
Cdd:PLN02324 384 QSDDGTWkLNGDRSKKKQEEEDE 406
PLN02802 PLN02802
triacylglycerol lipase
 88-441 7.01e-100

triacylglycerol lipase


Pssm-ID: 215432  Cd Length: 509  Bit Score: 310.16  E-value: 7.01e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836   88 TWRKIQGEDDWAGLMDPMDPVLRSELIRYGEMAQACYDAFDFDPFSRYCGSCRftRRHLFdslgIIDSGYEVARYLYATS 167
Cdd:PLN02802 136 RWRELHGENGWEGLLDPLDENLRRELVRYGEFVQAAYHAFHSNPAMSAEAPGR--PRHVA----LPDRSYRVTKSLFATS 209

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836  168 NINLPNfFSKSRWSKVW-SKNANWMGYVAVSDDNEATRcRLGRRDIAIAWRGTVTRLEWIADLKDFLKPVSG-NGFRCPD 245
Cdd:PLN02802 210 SVGLPK-WADDVAPDGWmTQRSSWVGYVAVCDSPREIR-RMGRRDIVIALRGTATCLEWAENLRAGLVPMPGdDDDAGDQ 287

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836  246 PAVKAESGFLDLYTdkdTSCNFSKfSAREQVLTEVKRLVERYgdeEGEELSITVTGHSLGGALAVLSAYDVAemgvnrTR 325
Cdd:PLN02802 288 EQPKVECGFLSLYK---TAGAHVP-SLSESVVGEVRRLMEKY---KGEELSITVTGHSLGAALALLVADELA------TC 354

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836  326 KGKVIPVTAFTYGGPRVGNIRFKERIEKLGVKVLRVVNEHDVVAKSPGLFLNERAPQalmklagglpWCYSHVGEMLPLD 405
Cdd:PLN02802 355 VPAAPPVAVFSFGGPRVGNRAFADRLNARGVKVLRVVNAQDVVTRVPGIAPREELHK----------WAYAHVGAELRLD 424

                        330       340       350
                 ....*....|....*....|....*....|....*.
gi 30679836  406 HQKSPFLKPTVDLSTAHNLEALLHLLDGYHGKGQRF 441
Cdd:PLN02802 425 SKMSPYLRPDADVACCHDLEAYLHLVDGFLGSNCPF 460
PLN02408 PLN02408
phospholipase A1
 93-447 4.12e-97

phospholipase A1


Pssm-ID: 215228  Cd Length: 365  Bit Score: 298.29  E-value: 4.12e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836   93 QGEDDWAGLMDPMDPVLRSELIRYGEMAQACYDAFDFDPFSRYCGSCRFTRRHLFDSLGIIDSGYEVARYLYATSNINLP 172
Cdd:PLN02408   4 QGIRNWDGLLDPLDDNLRGEILRYGDFVEAAYKSFDFDPSSPTYATCRFPKSTLLERSGLPNTGYRLTKHLRATSGIQLP 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836  173 NFFSK-SRWSkvwSKNANWMGYVAVSDDNEATrCRLGRRDIAIAWRGTVTRLEWIADLKDFLKPVSGNGFRCPDPAVKA- 250
Cdd:PLN02408  84 RWIEKaPSWV---ATQSSWIGYVAVCQDKEEI-ARLGRRDVVIAFRGTATCLEWLENLRATLTRLPNAPTDMNGSGDGSg 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836  251 ---ESGFLDLYTDKDTSCNfskfSAREQVLTEVKRLVERYGDeegEELSITVTGHSLGGALAVLSAYDVAemgvnrTRKG 327
Cdd:PLN02408 160 pmvESGFLSLYTSGTAMGP----SLQEMVREEIARLLQSYGD---EPLSLTITGHSLGAALATLTAYDIK------TTFK 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836  328 KVIPVTAFTYGGPRVGNIRFKERIEKLGVKVLRVVNEHDVVAKSPGLFL-NERAPQALMKL-AGGLP-----------WC 394
Cdd:PLN02408 227 RAPMVTVISFGGPRVGNRSFRRQLEKQGTKVLRIVNSDDVITKVPGFVIdGENDVAKKRDVnVAGLPswiqkrvedtqWV 306

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836  395 YSHVGEMLPLDHQKSPFLKpTVDLSTAHNLEALLHLLDG-------YHGKGQRFVLSSGR 447
Cdd:PLN02408 307 YAEVGRELRLSSKDSPYLN-SINVATCHDLKTYLHLVNGfvsstcpFRATAKRVLGRHHR 365
Lipase_3 cd00519
Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into ...
 143-406 1.53e-49

Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the process of becoming active at the lipid/water interface, although several examples of lipases have been identified that do not undergo interfacial activation . The active site of a lipase contains a catalytic triad consisting of Ser - His - Asp/Glu, but unlike most serine proteases, the active site is buried inside the structure. A "lid" or "flap" covers the active site, making it inaccessible to solvent and substrates. The lid opens during the process of interfacial activation, allowing the lipid substrate access to the active site.


Pssm-ID: 238287 [Multi-domain]  Cd Length: 229  Bit Score: 169.96  E-value: 1.53e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836 143 RRHLFDSLGIIDSGYEVARYLYAT----SNINLPNFFSKSRWSKvWSKNANWMGYVAVSDDneatrcrlgRRDIAIAWRG 218
Cdd:cd00519   2 YEKLKYYAKLAAAAYCVDANILAKavvfADIALLNVFSPDKLLK-TDKQYDTQGYVAVDHD---------RKTIVIAFRG 71

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836 219 TVTRLEWIADLKDFLKPVSgngfRCPDPAVKAESGFLDLYTdkdtscnfskfSAREQVLTEVKRLVERYGDeegeeLSIT 298
Cdd:cd00519  72 TVSLADWLTDLDFSPVPLD----PPLCSGGKVHSGFYSAYK-----------SLYNQVLPELKSALKQYPD-----YKII 131

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836 299 VTGHSLGGALAVLSAYDVAEMGVNRtrkgkviPVTAFTYGGPRVGNIRFKERIEKLGVKVLRVVNEHDVVAKSPGLFLNe 378
Cdd:cd00519 132 VTGHSLGGALASLLALDLRLRGPGS-------DVTVYTFGQPRVGNAAFAEYLESTKGRVYRVVHGNDIVPRLPPGSLT- 203

                       250       260
                ....*....|....*....|....*...
gi 30679836 379 rapqalmklaggLPWCYSHVGEMLPLDH 406
Cdd:cd00519 204 ------------PPEGYTHVGTEVWIDH 219
Lipase_3 pfam01764
Lipase (class 3);
214-375 1.46e-47

Lipase (class 3);


Pssm-ID: 396362 [Multi-domain]  Cd Length: 139  Bit Score: 161.27  E-value: 1.46e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836   214 IAWRGTVTRLEWIADLKDFLKPVSGngfrCPDPAVKAESGFLDLYTdkdtscnfskfSAREQVLTEVKRLVERYGDeege 293
Cdd:pfam01764   2 VAFRGTNSILDWLTDFDFSLTPFKD----FFLGGGKVHSGFLSAYT-----------SVREQVLAELKRLLEKYPD---- 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836   294 eLSITVTGHSLGGALAVLSAYDVAEMGVNRtrkgkVIPVTAFTYGGPRVGNIRFKERIEKLGVK-VLRVVNEHDVVAKSP 372
Cdd:pfam01764  63 -YSIVVTGHSLGGALASLAALDLVENGLRL-----SSRVTVVTFGQPRVGNLEFAKLHDSQGPKfSYRVVHQRDIVPRLP 136


                  ...
gi 30679836   373 GLF 375
Cdd:pfam01764 137 PIV 139
Lip2 COG3675
Predicted lipase [Lipid transport and metabolism];
208-409 5.66e-22

Predicted lipase [Lipid transport and metabolism];


Pssm-ID: 442891 [Multi-domain]  Cd Length: 266  Bit Score: 95.59  E-value: 5.66e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836 208 GRRDIAIAWRGTVTRLEWIADLKDFLKPVSGNGfrcpdPAVKAESGFLDLYTdkdtscnfskfSAREQVLTEVKRLvery 287
Cdd:COG3675  25 SDDEVIVAFRGTESLTDWLTNLNAAQVPYPFAK-----TGGKVHRGFYRALQ-----------SLRELLEDALRPL---- 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836 288 gdeeGEELSITVTGHSLGGALAVLSAYDVAEMGVNrtrkgKVIPVtaFTYGGPRVGNIRFKERIEKLGVKVLRVVNEHDV 367
Cdd:COG3675  85 ----SPGKRLYVTGHSLGGALATLAAADLERNYIF-----PVRGL--YTFGQPRVGDRSFAKYYNLHVPNSYRIVNNNDI 153

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 30679836 368 VAKSPglflneraPQalmklagglPWCYSHVGEMLPLDHQKS 409
Cdd:COG3675 154 VPLLP--------PV---------WMGYDHVGKLLWLDSLRK 178
Lipase cd00741
Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and ...
 252-422 2.39e-19

Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of becoming active at the lipid/water interface, although several examples of lipases have been identified that do not undergo interfacial activation . The active site of a lipase contains a catalytic triad consisting of Ser - His - Asp/Glu, but unlike most serine proteases, the active site is buried inside the structure. A "lid" or "flap" covers the active site, making it inaccessible to solvent and substrates. The lid opens during the process of interfacial activation, allowing the lipid substrate access to the active site.


Pssm-ID: 238382 [Multi-domain]  Cd Length: 153  Bit Score: 84.86  E-value: 2.39e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836 252 SGFLDLYTdkdtscnfskfSAREQVLTEVKRLVERYGDEegeelSITVTGHSLGGALAVLSAYDVAEMGVNRtrkgkviP 331
Cdd:cd00741   1 KGFYKAAR-----------SLANLVLPLLKSALAQYPDY-----KIHVTGHSLGGALAGLAGLDLRGRGLGR-------L 57

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836 332 VTAFTYGGPRVGNIRFKERI--EKLGVKVLRVVNEHDVVAKSPglflnerapqalmklagGLPWCYSHVGEMLPLDHQKS 409
Cdd:cd00741  58 VRVYTFGPPRVGNAAFAEDRldPSDALFVDRIVNDNDIVPRLP-----------------PGGEGYPHGGAEFYINGGKS 120

                       170
                ....*....|...
gi 30679836 410 PFLKPTVDLSTAH 422
Cdd:cd00741 121 QPGCCKNVLEAVD 133
CVT17 COG5153
Putative lipase ATG15 (essential for vacuolar disintegration of autophagic bodies) ...
 211-371 3.92e-07

Putative lipase ATG15 (essential for vacuolar disintegration of autophagic bodies) [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 444061  Cd Length: 405  Bit Score: 52.33  E-value: 3.92e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836 211 DIAIAWRGTVTRLEWIADLKDFLKP-VSGNGFRCPDPAVKAESGFlDLYTDKDTSCNFskfsarEQVLTEVKRLVERYGD 289
Cdd:COG5153  46 DTIIAFRGTQGKPDWKTDINASLHDyDEKNKEADEKLPLQVHEGF-EQYAAQVMDLDY------DGAEELAAEVKKQYPD 118

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836 290 EEgeelsITVTGHSLGGALAVLSAYDVAemgvnrtrkgkvipVTAFTYGGPRVGNIRFKERIEKlGVKVLRVVNEHDVVA 369
Cdd:COG5153 119 AE-----LSLTGHSLGGALASLVAVATG--------------LSKVTFAAPGSGNHALADDLGK-RIDAGEFVKSLDAVA 178


                ..
gi 30679836 370 KS 371
Cdd:COG5153 179 GP 180
PLN00413 PLN00413
triacylglycerol lipase
 299-372 6.03e-05

triacylglycerol lipase


Pssm-ID: 165792  Cd Length: 479  Bit Score: 45.39  E-value: 6.03e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836  299 VTGHSLGGAL-----AVLSAYDVAEMgVNRTRKgkvipvtAFTYGGPRVGNIRF----KERIEKLGVKVLRVVNEHDVVA 369
Cdd:PLN00413 288 LSGHSLGGALailftAVLIMHDEEEM-LERLEG-------VYTFGQPRVGDEDFgifmKDKLKEFDVKYERYVYCNDMVP 359


                 ...
gi 30679836  370 KSP 372
Cdd:PLN00413 360 RLP 362
PLN02162 PLN02162
triacylglycerol lipase
 293-372 1.85e-03

triacylglycerol lipase


Pssm-ID: 177821  Cd Length: 475  Bit Score: 40.80  E-value: 1.85e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679836  293 EELSITVTGHSLGGALAVLSAYDVAEMGVNRTRKgKVIPVtaFTYGGPRVGNIRFKE----RIEKLGVKVLRVVNEHDVV 368
Cdd:PLN02162 276 KNLKYILTGHSLGGALAALFPAILAIHGEDELLD-KLEGI--YTFGQPRVGDEDFGEfmkgVVKKHGIEYERFVYNNDVV 352


                 ....
gi 30679836  369 AKSP 372
Cdd:PLN02162 353 PRVP 356
PLN02934 PLN02934
triacylglycerol lipase
 299-372 2.52e-03

triacylglycerol lipase


Pssm-ID: 215504  Cd Length: 515  Bit Score: 40.54  E-value: 2.52e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 30679836  299 VTGHSLGGALAVLSAyDVAEMGVNRTRKGKVIPVtaFTYGGPRVGNIRF----KERIEKLGVKVLRVVNEHDVVAKSP 372
Cdd:PLN02934 325 VTGHSLGGALAILFP-TVLVLQEETEVMKRLLGV--YTFGQPRIGNRQLgkfmEAQLNYPVPRYFRVVYCNDLVPRLP 399
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH